Curriculum Summary

Khalid Majid Fazili, Ph.D Professor and Head, Department of Biotechnology University of Kashmir, Srinagar, Jammu and Kashmir (India) e-mail: fazili@kashmiruniversity.ac.in, Cell: +91-9419003881

Education: PhD (Biochemistry) Current status: Professor Teaching Experience: 25 years

Teaching Experience

Department of Biotechnology, University of Kashmir, Srinagar

Professor (3rd June, 2012 - till date) [ Five Years] Head of Department: From 09/06/2012 to 8/06/2015 Associate Professor 2006 -2012 (Six years) Assistant Professor 1991-2006 (Fifteen years)

Qassim University, College of Medicine, Buraida, Al Qassim, Kingdom of Saudi Arabia

Associate Professor 24/05/2008 - 02/03/2011 (2years 10 months) (Biochemistry)

Research Experience

Publications / Presentations Forty nine (49) Funded Projects (Ongoing) Two Funded Projects (completed) Three PhD (ongoing) Eight PhD supervised Seven Invited Lectures Twenty Courses organized Six Conferences attended Sixteen Orientation / refresher Courses attended Four

Personnel details:

Passport number: J5368811 Date of Issue: 23/02/2011 Date of Expiry 22/02/2021 Place of Issue: Riyadh, Kingdom of Saudi Arabia

CURRICULUM VITAE Khalid Majid Fazili, Ph.D Professor and Head, Department of Biotechnology (http://biotechnology.uok.edu.in/) University of Kashmir, Srinagar, Jammu and Kashmir (India) e-mail: fazili@kashmiruniversity.ac.in, Cell: +91-9419003881 _____________________________________________________________________ Professional carrier

3/05/2012 onwards Professor Department of Biotechnology

University of Kashmir, Srinagar

9 /05/2012 to 9/5/2015 Professor and Head Department of Biotechnology

University of Kashmir, Srinagar

03 /05 /2009 – 02/05/2012 Associate Professor Department of Biotechnology University of Kashmir, Srinagar

24 /05 /2008 - 02 / 03/ 2011 Associate Professor (Biochemistry) College of Medicine, Qassim University Kingdom of Saudi Arabia, KSA

03 /05 /2006 – 02/ 05/ 2009 Reader, Department of Biotechnology University of Kashmir, Srinagar

16 /03 /1999 – 02 /05 /2006 Senior Assistant Professor Department of Biochemistry University of Kashmir, Srinagar

11 /10/ 1991 – 15/03/1999 Assistant Professor Department of Biochemistry University of Kashmir, Srinagar

01/03/ 1991 - 10 /10/ 1991 Assistant Professor (Biochemistry), SKUAST, Srinagar, J&K (India)

11/10/1089 – 28/2/1991 Junior Resident (In-charge) Emergency Lab SK Institute of Medical Sciences, Sour Srinagar _________________________________________________________________________ Education

PhD Biochemistry 1991 Aligarh Muslim University, Aligarh (India) M. Phil Biochemistry 1986 Aligarh Muslim University, Aligarh (India) M. Sc Biochemistry 1984 University of Kashmir, Srinagar, J & K, (India) B. Sc Chemistry, Biology 1982 University of Kashmir, Srinagar, J & K, (India) __________________________________________________________________________

Publications

1. Irfana Reshi, Zarka Sarwar, Sameer Ahmed Bhat, Syed Qaaifah Gillani, Misbah Shah, Khalid Majid Fazili, Shaida Andrabi (2018) Polyoma small T upregulates the expression of cytoskeletal proteins in mammalian cells during mitosis: International Journal of Biological Macromolecules, 107, Part B, 2279-2284

2. Uzma Noor Shah, Javeid Iqbal Mir, Nazeer Ahmad, Sumira Jan and Khalid Majid Fazili (2017) Bioefficacy potential of different genotypes of walnut Juglans regia L.: Journal of Food Science and Technology, https://doi.org/10.1007/s13197-017-2970-4, P 1-14

3. Younis Mohammad Hazari, Irfana Reshi, Mudasir Habib and Khalid Majid Fazili (2017) Expression and purification of p70ΔCT104 S6 K, a 72 kDa c-terminal truncated p70S6 kinase-GST fusion protein in bacterial expression system: International Journal of Biological Macromolecules, 102, 625–629

4. Mudasir Habib, Younis Mohammed Hazari, Syed Tanveer Iqbal, Tasleem Ahmed Shamas Ganaib, Feroz Din Sheikh, Khurshid Iqbal Andrabi and Khalid Majid Fazili (2017) Novel variations in 5′ flanking region of the α-Lactalbumin gene in exotic and indigenous cattle, Meta Gene 13, 149–153

5. Younis M Hazari, Arif Bashir, Mudasir Habib, Samirul Bashir, Huma Habib, M. Abul Qasim, Naveed Nazir Shah, Ehtishamul Haq, Jeffrey Teckman and Khalid Majid Fazili (2017) Alpha-1-antitrypsin deficiency: Genetic variations, clinical manifestations and therapeutic interventions. Mutation Research Reviews, 773, 14-25

6. Iram Ayoob, Younis M. Hazari, Shabir H. Lone, Shakeel-u-Rehman, Mohammad A. Khuroo, Khalid M. Fazili and Khursheed A. Bhat (2017): Phytochemical and Cytotoxic Evaluation of Peganum Harmala: Structure Activity Relationship Studies of Harmine. Chemistry Select 2017, 2, 2965 – 2968

7. Masood-ur-Rahman, Younis Mohammad, Khalid Majid Fazili, Khursheed Ahmad Bhatb and Tabassum Ara (2017): Synthesis and biological evaluation of novel 3-O-tethered triazoles of diosgenin as potent anti-proliferative agents. STEROIDS, 117, 1-8: http://dx.doi.org/10.1016/j.steroids.2016.11.003

8. Younis Mohammad Hazari, Arif Bashir,, Ehtisham ul Haq and Khalid Majid Fazili (2016): Emerging tale of UPR and cancer: an essentiality for malignancy. Tumour Biol. 37 (11), 14381-14390.

9. Arif Bashir, Naveed Nazir Shah, Younis Mohammad Hazari, Mudasir Habib, Samirul Bashir, Nazia Hilal, Mariam Banday, Syed Asrafuzzaman and Khalid Majid Fazili (2016): Novel variants of SERPIN1A gene: Interplay between alpha1-antitrypsin deficiency and chronic obstructive pulmonary disease; Respiratory Medicine ; 117, 139-149.

10. Sehar Saleem Bhat, Arif Ali Parray, Umar Mushtaq, Khalid Majid Fazili and Firdous Ahmad Khanday (2016) Actin depolymerization mediated loss of SNTA1 phosphorylation and Rac1 activity has implications on ROS production, cell migration and apoptosis ; Apoptosis. 21 (6): 737-48.

11. Younis Mohammad Hazari, Mudasir Habib, Samirul Bashir, Arif Bashir, Nazia Hilal, Ehtisham ul Haq and Khalid Majid Fazili (2016): Natural osmolytes alleviate GRP78 and ATF-4 levels: corroboration for potential modulators of unfolded protein response: Life Sciences, 146, 148-153

12. Nida Hassan, Farida Noor, Shabir Ahmad and Khalid Majid Fazili (2016): Age of fusion of the distal radial and ulnar epiphyses from hand radiographs—A study in Kashmiri population . Science and Justice, 56 (6) 431-436.

13. Uzma Noor Shah, J.I. Mir, N. Ahmed and Khalid M. Fazili (2016) Assessment of germplasm diversity and genetic relationships among walnut (Juglans regia L.)genotypes through microsatellite markers: Journal of the Saudi Society of Agricultural Sciences (In Press) http://dx.doi.org/10.1016/j.jssas.2016.07.005

14. Huma Habib, Khalid Majid Fazili, Mohammad Afzal Zargar and Bashir Ahmed Ganie (2016): Protease Inhibitor Associated Antimicrobial Activity of Pea Pisum sativum L. cv. Arkel. Int. J. Pure App. Biosci. 4 (1): 172-179

15. Arif Bashir, Abid Yousuf Miskeen, Younis Mohammad Hazari, Syed Asrafuzzaman and Khalid Majid Fazili (2015) Fusobacterium nucleatum, inflammation, and immunity: the fire within human gut : Tumor Biology, 37, 3, , 2805–2810. http://link.springer.com/article/10.1007%2Fs13277-015-4724-0

16. Sumira Bashir, Khalid Majid Fazili and Khurshid Iqbal Andrabi (2015): Screening of chicken RBC’s for the induction of heat stable protein (HSP40) in response to anisomysin. European Academic Research, 3,8, 2057-2067

17. F Ahmad, KM Fazili, TA Sofi, AA Waza, R Rashid (2015) Comparative Molecular Characterization of three Diplozoon species from Fishes of Kashmir Valley: Agricultural Advances 4 (7), 65-83

18. F Ahmad, TA Sofi, KM Fazili, BA Sheikh, BA Lone (2015) Chromosomes of Two Species of Acanthocephalans Collected from the Fishes of Kashmir Valley, India: J Veterinar Sci Technol 6 (253), 2

19. Arif Bashir, Abid Yousuf Miskeen, Ashaqullah Bhat, Khalid Majid Fazili, and Bashir Ahmad Ganai (2014) Fusobacterium nucleatum: An Emerging Bug in Colorectal Tumorigenesis. European Journal of Cancer Prevention,, 24(5):373-85.

20. Syed Tanveer Iqbal, Khurshid Iqbal Andrabi, Azmat Alam Khan, Khalid Majid Fazili (2013), Acetylation Induced Conformational Variation in α-Lactalbumin. International Journal of Modern Chemistry, 2013, 4(2): 117-125

21. Syed Tanveer Iqbal, Khurshid Iqbal Andrabi, Khalid Majid Fazili and Azmat Alam Khan (2013), Coding variations in bovine α-lactalbumin in Kashmiri cattle vis-a-vis exotic breeds. Indian Journal of Animal Sciences, 83(8), 848-850.

22. Mehanaa, E. E AbdelRaheim M. A. Meki, and Khalid Majid Fazili (2012), Ameliorated effects of green tea extract on lead induced liver toxicity in rats. Exp Toxicol Pathol 64, 291-295.

23. Huma Habib, Mohammad Afzal Zargar, Khalid Majid Fazili (2012), Cloning and Expression of Trypsin Inhibitor Gene ti from Pea (Pisum sativum L.) cv. Arkel. in Escherichia coli DH5α Cells. In: Deepika R (ED) Protease Inhibitors. Functional Plant Science and Biotechnology 6 (Special issue 1), 86-90.

24. Khalid Majid Fazili ( 2012), Invited Foreword for “Functional Plant Science and Biotechnology” special issue on Protease Inhibitors: Global Science Publishers, Japan, 2012

25. Khali Majid Fazili, Yousuf Ali, Syed Sajjad Hussain, Arshid Andrab, Bashir Ahmad Wafai (2011) Karyotype of apomictic Dandelion (Taraxacum officinale), a wild plant with high medicinal value. Recent Research in Science and Technology, 3(10): 118-121. ISSN: 2076-5061

26. Hameed M, Ahmad B, Khan RH, Andrabi KI, Fazili KM.(2009), Tertiary butanol induced amyloidogenesis of hen egg white lysozyme (HEWL) is facilitated by aggregation-prone alkali-induced molten globule like conformational state. Protein Pept Lett. 2009;16(1):56-60.

27. Rasool, R., Bilal, N., Habib,H., and Fazili K.M. (2009) Evaluation of protease inhibitory activity in pea (pisum sativum) J.Res. Develop,9, 84-89.

28. Huma Habib and Khalid Majid Fazili (2007), Plant protease inhibitors: a defense strategy in plants. Biotechnology and Molecular Biology Review ,2,3, 68-85,

29. Hameed M, Ahmad B, Fazili KM, Andrabi K, and Khan RH(2007): Different molten globule like folding intermediates of hen egg white lysozyme induced by high pH and tertiary butanol. J Biochem (Tokyo) , 141 , 4, 573-583

30. Parray,B.A , Ganai, A.M. and Fazili, K.M. ( 2007). Physicochemical parameters and growth yield of Tomato (Lycoperiscum esculentum) : Role of Farm Yard Manure and Neemcake. American-euro asian Journal Agricul Env. , 2(3) , 303-307. http://www.idosi.org/aejaes/jaes2(3)/15.pdf

31. Wani, S.A; Makhdomi, S and Fazili, K.M (2002) Guanidine hydrochloride induced unfolding of human hemoglobin A: J.Oriental sciences 2002) J. Oriental sciences, 8 , 2 , 63-73.

32. Fazili, K.M, Mir, M. M. and Qasin, M. A (1993) : Changes in protein stability upon chemical modification of lysine residues of bovine serum albumin by different reagents. Biochem. and Mol. Biol. Int. 31,807-816.

33. Fazili, K.M, Mir, M. M. and Qasin, M. A (1993) Conformation and bilirubin binding properties of acetylated, carbamylated and guanidinated bovine serum albumins. Biochem. (Life sci. Adv.) 12, 81-88

34. Mir, M. M., Fazili, K.M and Qasin, M. A (1992) Chemical modification of buried lysine residues of bovine serum albumin and its influence on protein conformation and bilirubin binding. Biochem. Biophys. Acta, 1119, 261-267

35. Mir, M. M., Fazili, K.M and Qasin, M. A (1988) :Influence of surface charge on the solubility behavior of porcine gamma globulin. Med. Sci. Res. 16 463-464

36. Fazili, K.M and Qasin, M. A. (1984): Purification and some properties of buffalo liver cathepsin B: J. Biochem. 100, 295-299

37. Mahrukh Hameed, , Rizwan Hasan Khan and Khalid Majid Fazili ( 2007) Tertiary butanol induced aggregation in hen egg white lysozyme at pH 12.0. International Symposium on Structure and stability of macromolecules , Kosic , Institute of Experimental Biophysics , Solvak academy of Sciences, Solvak.

38. B.A.Parray, Khalid Majid Fazili and A.M.Ganie. (2006): Effect of Farm Yard Manure (FYM) and Neemcake on growth yield and biochemical properties of tomato (lysopersicon esculantum). Proceedings of the fourth Euro-Arab environmental conference held at Kuwait Institute of scientific Research , Kuwait from Nov.,27 to 29 , 2006

39. Mahrukh Hameed, Basir Ahma, Khalid Majid Fazili and Rizwan HasanKhan (2006): Different molten globule like folding intermediates of hen egg white lysozyme induced by high pH and tertiary butanol : Proceedings of Jammu &

Kashmir, Science congress held at University of Kashmir

40. Huma Habib , Khalid Majid Fazili and M.Afzal Zargar (2006): Protease inhibitory activity in aqueous extracts of Pea ( Pisum sativum) seeds. Proceedings of J & K Science Congress held at University of Kashmir

41. Fazili , K.M (2005): Proteomics, Approaches and Applications Proceedings of The 22 day training programme in Parasitology , Molecular Biology and Immunodiagnostics held at the Department of zoology , University of Kashmir , Srinagar from 15th September , 2005

42. Amin,S Hans , R.K., Farooq , M. and Fazili , K.M and Masood , A(2004) Effect of sulphur dioxide on the activity of zea mays phosphoenol pyruvate carboxylase, Proceedings of the 74th Annual Meeting of the Society of Biological Chemists, India held at Pantnagar from Nov21 to 24.

43. Fazili , K.M and Wani, S.A (2003) Denaturant induced unfolding of apo α and β-chains of hemoglobin : Proceedings of the 10th congress of the Federation of Asian and Oceanic Biochemists and Molecular Biologists (FAOBMB) held at Bangalore , India from December , 7 to 11.

44. Fazili, K.M. and Udgaonkar, J.B (1999) Diffusion control in multistate folding and unfolding of barstar, International symposium on frontiers in structural Biology held at Indian Institute of Sciences, Bangalore, from August 26 to August 28,

45. Fazili , K.M (1995) Chemical modification of the constituent amino acid residues of proteins and their stability: Proceedings of the 16th International congress of Biochemistry and Molecular Biology (IUBMB) held at New Delhi from October 19 to October 22

46. Fazili , K.M, Mir, M. M. and Qasim,M. A. (1989) Studies on the interaction of bilirubin with bovine serum albumin:Proceedings of the 58th Annual general meeting of the society of Biological Chemists (India) held at Izzatnagar from October 16 to October18

47. Tayyab, S and Fazili , K.M (1989) Binding of quercitin with bovine serum albumin :Proceedings of the 58th annual general meeting of the society of Biological Chemists (India) held at Izzatnagar from Oct. 16 to Oct. 18.

48. Mir, M.M, Fazili , K.M and M.A.Qasim (1988). Involvement of lysine residues in bilirubin- Albumin interaction: Proceedings of the 57th annual general meeting of the society of Biological Chemists (India) held at New Delhi from October 9 to 12.

49. Fazili , K.M Mir, M.M and Qasim, M.A (1988) Role of lysine residues in the stability of bovine serum albumin: Proceedings of the 57th annual general meeting of the society of Biological Chemists (India) held at Delhi from October 9 to 12.

50. Fazili, K.M Mir, M.M and Qasim, M. A. (1987) Influence of charge on conformational properties of bovine serum albumin: Proceedings of the 56th annual general meeting of the Society of Biological Chemists (India) held at Tirupati from December 28 to December 30

51. Fazili , K.M (1985) Isolation and purification of buffalo liver cathepsin B : Proceedings of the 54th annual general meeting of the Society of Biological Chemists (India) held at Pantnagar from November 7 to November 9

Books

1. Mahrukh Hameed and Khalid Majid Fazili (2011). Protein Folding and Aggregation: Unfolding of Hen Egg White Lysozyme Lap Lambert Academic Publishing, Germany ISBN-10: 3847307916, ISBN-13: 978-3847307914

2. Khalid Majid Fazili and Syed Tanveer (2012). DNA Structure and Replication: Basic Concepts in Molecular Biology, Lap Lambert Academic Publishing, Germany ISBN-10: 3847328778, ISBN-13: 978-3847328773

3. Syed Tanveer Iqbal and Khalid Majid Fazili (2012) Genetic Polymorphism of Bovine Alpha- Lactalbumin, Lap Lambert Academic Publishing, Germany ISBN-10: 3847375601 , ISBN-13: 978-3847375609

Funded Research Projects (5)

# Ongoing projects Amount

1 Assessment of selected indigenous herbs of the Himalyan range as modulators of unfolded protein response : A novel strategy towards cancer regression Ministry of AYUSH, Govt. of India

Rs 53,89,330/=

2 A study of natural osmolytes as potential therapeutics for Z α1- antitrypsin induced COPD and liver cirrhosis Department of Biotechnology, Govt. of India, New Delhi

Rs 40,30,000/=

1

Projects completed

Genetic Analysis of Lactose Synthase Complex of Exotic High Milk yielding and Indigenous Low Milk Producing Bovine Breeds Department of Science & Technology, Govt. of India, New Delhi

Rs 48,30000/=

2 Effect of polyamines and ionic liquids on folding intermediates and solvent induced aggregation in Hen egg white lysozyme University Grants Commission, New Delhi

Rs 13,48,000/=

3 Exploring the potential consumable herbs of Kashmir region as a source of signal transduction modulators (STMs) to serve as modern drug leads. Indian Council of Medical Research, New Delhi

Rs 48,21,000/=

Research degree supervision (24)

Ph. D thesis ongoing (7)

1. Mudassir Habib ( 30/04/2011) Analysis of 5' promoter region of the α-lactalbumin gene in the endogenous Kashmiri breed (bos Taurus).”

2. Samirul Bashir (08/03/2014) Understanding the Unfolded Protein response mediated homeostatic switch: a cross talk between IRE1 and Bcl-2 family of proteins

3. Sameer Ahmad Bhat (Co-Supervisor , Shaida Andrabi) Deciphering the mechanism of Apoptosis through Dependance receptor UNC5B and protein phosphatase 2A interaction

4. Shayaq ul Abir (Co-Supervisor , Shajrul Amin) Association of genetic variants of INS, INSR and IRS 1 and IRS 2 genes with insulin resistance and hyperandrogenemia in Kashmiri women with Polycystic Ovarian syndrone

5. Mariam Banda, Deciphering of IRE1 associated factors involved in RIDD

6. Ozaira Qadri

7. Nida I Fatima

Ph.D Thesis Supervised (14)

1. Irfana Reshi ( Ph.D, Thesis submitted) Screening of Human Kinase Library for novel antiapoptotic proteins (kinases) by using ST of polyomas virus as screening tool

2. Arif Bashir (08/03/2014, Ph.D, Thesis submitted) Molecular profiling of SERPIN A! gene in emphysema patients in the Kashmir valley and its correlation with clinical phenotypes

3. Younis Mohammad Hazari (08/03/2014); Understanding the nature of cellular response to alpha 1 antitrypsin mutations with emphasis on Unfolded Protein Response

4. Huma Habib (Ph.D, 2008) Isolation and analysis of Protease inhibitors from Pea (Pisum sativum). Cloning and Characterization of trypsin inhibitor gene ti.

5. Mahrukh Hamid (Ph.D 2009) In vitro studies on aggregation and unfolding of Hen egg white lysozyme.

6. Showkat Ahmad Wani (Ph.D 2009) In Vitro Studies on Folding and Aggregation of Alpha and Beta Chains of Human Hemoglobin "A"

7. Basharat Ahmad Parray (Ph.D 2009) Effect of different levels of F.Y.M. and Neem Cake on growth, yield and quality profile of (Lycopersicon exculentum Mill) Cv. Explorer hybrid F1

8. Syed Tanveer Iqbal (Ph.D 2009) Genetic Polymorphism of Bovine Alpha lactalbumin

9. Rifat Ara (Ph.D 2009) Distribution,Analysis and Partial of Purification of Heat Stable Proteins in Sheep Liver Homogenate (As Co-supervisor)

10. Sumira Bashir (Ph.D 2009) Cloning, Expression and Differential Induction of Stress Response Proteins from Chicken (As Co-supervisor)

11. Nida (Prof. Farida Noor, Govt Medical College, Srinagar, Co-supervisor) Assessment of skeletal age in Kashmiri children by radiographic analysis

12. Uzma Noor (Prof Nazir Ahmad , CITH co-supervisor) , Molecular and biochemical characterization of walnut (Junglans regia L) genotype

13. Tanveer Ahmad

14. Nazima Gul

M. Phil thesis supervised (7)

1. Mohammed Younis (M.Phil, 2013) Expression and purification of P70ΔCT104S6 Kinase in bacterial expression system

2. Nazia Hilal (M. Phil, 08/03/2014) Screeniing and evaluation of indigeneous herbs of Kashmir as potent modulators of Unfolded Protein response

3. Syed Tanveer Iqbal (M. Phil, 2005) Preparation And Characterization of Chemically Modified A-Lactalbumin Derivatives

4. Huma Habib (M. Phil, 2005) Incidence of Hypertension among patients admitted at SKIMS between 1984 to 2001

5. Showkat Ahmad Wani (M. Phil, 2002) Studies on folding and un-folding of alpha chain of Human Hemoglobin A

6. Sameena Makhdoomi (M. Phil, 2002) Studies on folding and un-folding of Beta chain of Human Hemoglobin A

7. Shahid Khurshid Banday (M. Phil, 2015) (Supervisor, Mohammad Altaf Bhat) Histone repair in gene silencing and DNA repair

Invited / Extension Lectures (23)

1. General features and Mechanism of DNA Replication in Prokaryotes: Lecture delivered on 28th October, 2017 during Academies of Sciences’ Refresher Course on Molecular Biology of Cell” for College and University teachers held at Department of Biochemistry, University of Kashmir , Srinagar from October 23 to November 06, 2017

2. DNA Replication in Eukaryotes: Lecture delivered on 4th November, 2017 during Academies of Sciences’ Refresher Course on Molecular Biology of Cell” for College and University teachers held at Department of Biochemistry, University of Kashmir, Srinagar from October 23 to November 06, 2017

3. The dilemma of Unfolded Protein Response: Talk delivered on 20th May, 2017 during Refresher Course in Biosciences at Academic Staff College, University of Kashmir, Srinagar

4. Understanding Unfolding Protein Response: Lecture delivered on 12/02/2016 during Interdisciplinary Winter School for College and University teachers organized by ASC , University of Kashmir .

5. “The Bio Molecules”: Invited Lecture delivered on 27/01/2016 during 70th General Orientation Course organized by UGC Human Resource Development (HRD) Centre , University of Kashmir from 11/01/2016 to 06/102/ 2016.

6. The Penicillin Story: Lecture delivered on 16/11/2015 during 69th General Orientation Course Course organized by UGC Human Resource Development (HRD) Centre , University of Kashmir from 05/11/2015 to 04/12/2015.

7. Protein misfolding and aggregation :Lecture delivered on 21/02/2015 during Special winter School Refresher Course organized by ASC , University of Kashmir from 10/02/2015 to 03/03/2015.

8. Understanding Unfolding Protein Response : Lecture delivered on 21/02/2015 during Special winter School Refresher Course organized by ASC , University

of Kashmir from 10/02/2015 to 03/03/2015.

9. From Lifeless molecules to living complexities: Talk delivered on 23rd August, 2014 at University of Kashmir, Academic Staff College during the Interdisciplinary Refresher course cum Summer school for College and University teachers, organized by Academic Staff College in collaboration with University Grants Commission.

10. Introduction to the Problem Based Learning System: Talk delivered on 23rd August, 2014 at University of Kashmir during the Interdisciplinary Refresher course cum Summer school for College and University teachers, organized by Academic Staff College in collaboration with University Grants Commission.

11. Techniques and applications in Protein Biotechnology: Extension lecture delivered on October, 14, 2013 in University Grants Commission (UGC) sponsored General Orientation Course for College and University teachers held at Academic Staff College, University of Kashmir, Srinagar from October 3rd to Oct. 24th , 2013

12. Protein Biotechnology: Lecture delivered at Centre for Biodiversity and Biotechnology, Baba Ghulam Shah University, Jammu on 18th April, 2013

13. Perspectives in Protein Biotechnology: Invited Lecture: Delivered during UGC SAP DRS-I sponsored Two Day Lecture Series titled: “Recent Trends in Biotechnology” at School of Biotechnology, Shri Mata Vaishno Devi University (SMVD, Jammu on 9th November, 2012.

14. New Technologies in Proteomics, Extension lecture delivered on Dec., 4, 2007 in University Grants Commission (UGC) sponsored Refresher Course in environmental Sciences for College and University teachers held at Department of Environmental Sciences, University of Kashmir, and Srinagar from December 3 to December 25, 2007

15. Protein structure and Folding, , Extension lecture delivered on Dec., 6, 2007 in University Grants Commission (UGC) sponsored Refresher Course in environmental Sciences for College and University teachers held at Department of Environmental Sciences, University of Kashmir , Srinagar

16. Proteomics, Approaches and Applications , Talk delivered on 15th September , 2005 to the participants of the 22 day training program in Parasitology , Molecular Biology and Immunodiagnostics held at the Department of Zoology, University of Kashmir , Srinagar

17. Application of Bioinformatics in proteomics: A talk delivered on 7th September

at the 3 day training Program in Bioinformatics held at Bioinformatics center , University of Kashmir , Srinagar from 5th September to 7th September , 2005.

18. Current status and Challenges in Biochemistry : A one day seminar organized by the Department of Biochemistry, Government College for Women , M A Road ,Srinagar August , 2004

19. University Grants Commission (UGC) sponsored Refresher Course in Botany for College and University teachers held at Department of Botany University of Kashmir , Srinagar , August , 2003

20. University Grants Commission (UGC) sponsored Refresher Course in Zoology for College and University teachers held at Department of Zoology University of Kashmir, Srinagar : July , 2003

21. National Eligibility Test for Lecturers (NET ) Crash Coaching Program in Life Sciences at University of Kashmir , Srinagar : June , 2003

22. Refresher Course in Zoology for 10+2 lecturers held at Govt. Higher Secondary Institute, Kothibag, Srinagar: Jan –Feb., 2001

23. Reorientation course in Unani Medicine organized by Regional Research Centre for Unani Medicine , Srinagar on October , 19 , 1998.

Courses organized (6)

1. Course Coordinator for Refresher course in Life Sciences organized by Department of Biotechnology in Collaboration with UGC Human Resource Development Centre , University of Kashmir from 27thApril to 18th May, 2015.

2. Course Coordinator for Interdisciplinary Refresher course in Applied Sciences organized by Academic Staff College for three weeks from 21st May, 2014 to 13th June, 2014.

3. Course Director for Interdisciplinary Summer school organized by Department of Biotechnology, University of Kashmir, Srinagar in Collaboration with Academic Staff College for three weeks from September, 10 to September, 30, 2013.

4. Convener Finance, Member, Local Organizing Committee, J& K Science Congress-2013 , and Regional Science Congress Run up to Indian Science Congress association meet-2013, held at University of Kashmir in collaboration with DST, Government of India and J&K State Department of Science & Technology from October 1st to October 3rd, 2013

5. Member, Local Organizing Committee, J& K Science Congress-2012 held at University of Kashmir in collaboration with DST, Government of India and J&K State Department of Science & Technology from September 17 to 19, 2012

6. In charge Finance; J& K Science Congress-2012 held at University of Kashmir in collaboration with DST, Government of India and J&K State Department of Science & Technology from September 17 to 19, 2012

Participation in Seminars/ Workshops/ Conferences (16)

1. Chairperson (9/10/2015): Technical Session 1, on Probiotics and Fermentation products during conference on Biotechnological Intervention for improvement of Food products organized by Department of Food technology, University of Kashmir, Srinagar from 9th September to 10th September, 2015

2. May9-10, 2015: BIOCME-2015, Advances in Biochemical and Molecular Diagnostics: Recent research Trends organized by Department of Biochemistry, Govt. Medical College, Srinagar – Judge in Poster presentations

3. Saudi International Medical Education Conference 2014 organized by Qassim University at King Khalid Cultural Centre, Buraidah from 24 th to 27th November, 2014.

4. J& K Science Congress-2013 , and Regional Science Congress Run up to Indian Science Congress association meet-2013, held at University of Kashmir in collaboration with DST, Government of India and J&K State Department of Science & Technology from October 1st to October 3rd, 2013

5. J& K Science Congress-2012 held at University of Kashmir in collaboration with DST, Government of India and J&K State Department of Science & Technology from September 17 to 19, 2012

6. College Research Day, of the Qassim University, College of Medicine held at Qassim University, KSA on 27th June, 2010.

7. Tutor training Workshop in Problem Based Learning held from January 7th to January 8th, 2009 at Medical Education Department, Qassim University, College of Medicine, KSA

8. Genome Analysis: A Bioinformatics Approach, Department of Biotechnology sponsored workshop held at Aligarh Muslim University from February 24th to February 25th, 2007.

9. Fourth Euro-Arab environmental conference held at Kuwait Institute of scientific Research, Kuwait from Nov., 27 to 29, 2006

10. XXVIII Annual Conference of Indian Society of Human Genetics on Human Genome and genetic disorders, held at Jammu University from Feb, 7 to 9 , 2003

11. 10th congress of the Federation of Asian and Oceanic Biochemists and Molecular Biologists (FAOBMB) held at Bangalore, India from December , 7 to 11 , 2003

12. Introduction to Bioinformatics & Biostatistics: September 4 to 6, 2001 at Bioinformatics centre, University of Kashmir, Srinagar

13. International symposium on Frontiers In Structural Biology: August, 25 to 27 , 1999 National Centre for Biological Sciences Bangalore

14. International workshop on Protein Structural Bioinformatics and Genomics: August, 28 , 1999. National Centre for Biological sciences , Bangalore

15. Short term training course on Techniques In Modern Biotechnology : April , 8 – 19 , 1996 , Regional Research Laboratory , Jammu

16. State level seminar on Recent Trends In Biological Sciences: December , 5th , 1998 Avinashilingam University, Coimbatore

Orientation / Refresher Courses (4)

1. UGC sponsored Refresher Course in Biosciences held at Jammu University in collaboration with Academic Staff College , University of Kashmir, Srinagar from December, 19th , 2002 to Jan , 17th , 2003

2. UGC sponsored Refresher Course in Biochemistry for College & University teachers held at Avinashalingam University , Coimbatore , India from Nov., 19th to Dec., 16th , 1998

3. A Course on “An Integrated Approach to Knowledge & Information” held at National Institute of Advanced Studies, Bangalore in collaboration with University Grants Commission and J. N. Centre for Scientific & Advanced Research, Bangalore from October 7th to November 2nd , 1996.

4. UGC sponsored General Orientation Course for College & University teachers held at Jammu University from Jan 17th to Feb., 10th, 1994

Contribution to Corporate Life and Management of the Institution

1. Member, Academic Council, University of Kashmir, Srinagar (May, 2012 to May 2015)

2. Member, Board of Research Studies in Biological science, University of Kashmir (May, 2012 to May 2015)

3. Chairman, Board of Post Graduate Studies in Biotechnology, University of Kashmir, Srinagar (May, 2012 to May 2015)

4. Member, Board of Post Graduate Studies in Clinical Biochemistry, University of Kashmir, Srinagar (May, 2012 to May 2015)

5. Member, Board of Post Graduate Studies in Biochemistry, University of Kashmir, Srinagar

6. Member, Board of Post Graduate Studies in Botany, University of Kashmir, Srinagar

7. Member, Board of Post Graduate Studies in Bio resource, University of Kashmir, Srinagar

8. Chairman, Board of Under Graduate Studies in Biotechnology, University of Kashmir, Srinagar (May, 2012 to May 2015)

9. Chairman, Departmental Research Committee (DRC) in Biotechnology, University of Kashmir, Srinagar (May, 2012 to May 2015)

10. Member Secretary, Departmental Advisory Committee, Department of Biotechnology, University of Kashmir, Srinagar (May, 2012 to May 2015)

11. Member Departmental Advisory Committee, Centre for Animal Biotechnology, SKUAST, Shuhama, Srinagar

12. Member, Board of Post Graduate Studies in Biodiversity and Biotechnology, Baba Ghulam Shah University, Rajouri, Jammu

13. Member, Board of Under Graduate Studies in Chemistry, University of Kashmir, Srinagar (2012 to 2015)

14. Member, Board of Studies, Department of Biotechnology, Central University of Kashmir, Srinagar

Membership of Professional Societies

1. Society of Biological Chemists (India) Life Member 2. Indian society of Human Genetics Life Member 3. Jammu & Kashmir Academy of Science Life Member 4. American Society of Microbiology Full Member 5. National Institute of Advanced Studies, Bangalore (India) Associate member 6. Jammu & Kashmir Academy of Science Member Executive Council

Fellowships

(1984-1986): Junior Research Fellow, Indian Counsel of Medical Research (ICMR)

(1986-1989): Senior Research Fellow, Council of Scientific and Industrial Research (CSIR), New Delhi

(1999): Short Term Visiting Fellow, National Centre for Biological Sciences, TIFR, Bangalore

References

1. Prof M Muzaffar Mir Department of Biochemistry College of Medical Sciences Bisha University, Bisha Kingdom of Saudi Arabia

mirmuzaffar11@gmail.com

3. Prof. Abdullah Ghasham Department of Pharmacy Formerly Dean College of Medical Sciences Qassim University, KSA

ghasham@ksu.edu.sa

2 . Prof. Qayyom Hussain Department of Biochemistry Aligarh Muslim University, Aligarh India

qayyumbiochem@gmail.com

4 Prof. Bashir Ahmad Ganai Department of Environmental Sciences Centre of Research for Development (CORD) University of Kashmir, Srinagar bbcganai@gmail.com

Teaching statement

Teaching has been one of my passions. To me, one of the most important factors in this

field is the classroom atmosphere; and building a proper atmosphere is the

responsibility of the teacher. Giving respect even to the most naughty / weakest student

in the class has been an important contributing factor. Although most of my teaching

years have been in the traditional system, but with a disliking for one-way information

flow, I always encourage interactive sessions and am elated by active participation of

students in the lecture. In practice, I strongly advocate and encourage interactive

teaching. My approach has always been student friendly, and I am proud on that count.

Over the past twenty-five years, I have served as a teacher, in many capacities;

lecturer, Assistant Professor, Reader, Associate Professor and Professor both at the

undergraduate and graduate levels teaching biochemistry in Kashmir and abroad. My

teaching specialties include Biomolecules, Proteins, Enzymology and Molecular

Biology. Today with the availability of information at fingertips, the teacher does not

serve as an information source, but is more of a facilitator and a guide. Interactive

teaching is what keeps all the parties involved in the class. My way of teaching is to

give respect to the students and reach to the weakest student in the class. I have always

believed that the success of a teacher is when he makes the students to realize their

responsibilities and evokes in them an interest to peruse and understand the subject.

During my short tenure of nearly three years at Qassim University, Kingdom of Saudi

Arabia, I have been involved in teaching biochemistry to The Medical students

through their basic phase. The College follows a hybrid PBL system that always

fascinated me. I have greatly enjoyed teaching and interactive sessions with the

wonderful students. Along with that my informal interactions with students, staff and

faculty made my stay memorable and has left an indelible mark through my memory

lane.

Khalid Majid Fazili

Research statement

My lab is currently focused on studying the ER stress and Unfolded Protein response Endoplasmic Reticulum stress (ER-stress) caused by disturbances in cellular homeostasis leads to the initiation of a set of cellular responses at transcriptional and translational level. The responses directed at restoration of the cellular homeostasis operate through three parallel pathways collectively called as Unfolded Protein Response (UPR). UPR has been associated with pathological conditions like cancer, diabetes, obesity, liver damage, neurodegenerative disorders and aggregation diseases Recent preclinical and clinical studies have shown some small molecules that selectively modulate UPR arms have immense therapeutic potential as plausible treatment for these diseased states. The main focus of our lab has been to study the unfolded response pathways in many diseased conditions including cancer, and to identify and develop new molecules that would modulate the unfolded protein response and could be employed in therapeutic intervention.