CURRICULUM VITAE

1. NAME IN FULL: THANGARAJAN RAJKUMAR

2. DATE OF BIRTH: 30-11-1957

3. ADDRESS & DESIGNATION:

a) Present: Professor and Head, Dept. of Molecular Oncology,

Cancer Institute (WIA), Adyar, Madras - 600020, India.

Phone: 22350131; 22350241. Fax: 24912085

Email: cancer_institute_wia@vsnl.com

drtrajkumar@gmail.com

b) Permanent: 92/2, BAAB Gandhi, 2nd Main Road,

Gandhinagar, Adyar,

Chennai – 600020, India

4. PROFESSIONAL QUALIFICATIONS:

DEGREE SUBJECT INSTITUTION/UNIVERSITY DURATION

MBBS Medicine Madras Medical College, 1975-1982

Madras - 600003, India.

University of Madras.

M.D. General Medicine Madras Medical College, 1982-1985

Madras - 600003, India.

University of Madras.

D.M. Medical Oncology Cancer Institute (WIA), 1986-1988

Adyar, Madras - 600020

University of Madras.

Ph.D. Science Royal Postgraduate Medical School, 1991-1994

(Molecular Oncology) Hammersmith Hospital, London, UK.

University of London.

HONOURS

1. First qualified Medical Oncologist with a Ph.D. in Basic Science (Molecular Oncology) in India.

2. Visiting Professor, Dept. of Clinical Oncology, RPMS and Hammersmith Hospital, London, UK.

Tamilnadu Medical Council Registration No: 35442

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5. POST-GRADUATE TRAINING/EXPERIENCEFROM TO NAME OF ORGANISATION AND NATURE OF

TRAINING16-07-85 15-01-86 Cancer Chemotherapy Dept., Govt. Royapettah Hospital,

Special Trainee

01-04-86 31-03-88 Post-graduate in Medical Oncology, Cancer Institute, Adyar

07-10-91 31-10-94 Research Fellow, ICRF Molecular Oncology Unit,

Hammersmith Hospital, London, UK.

APPOINTMENTS HELD

02-10-08 – till date. Professor and Head, Dept. of Molecular Oncology, Cancer Institute (WIA).

01-06-2006 till 01-10-08. Director and Scientific Director, & Professor and Head, Dept. of

Molecular Oncology, Cancer Institute (WIA). (Resigned Directorship on 01-10-08).

14-12-2000 -31-05-2006. Scientific Director, & Professor and Head, Dept. of Molecular Oncology,

Cancer Institute (WIA).

01-04-2000 till 13-12-2000. Director (Laboratories and Research), Chairman, Division of Biological

Sciences, Professor and Head, Dept. of Molecular Oncology, Cancer Institute (WIA).

2nd April 1997 -

to 31-03-2000. Deputy Director (Research), Chairman, Division of Biological Sciences, Professor

and Head, Dept. of Molecular Oncology, Cancer Institute (WIA).

1st April 1996 - 1st April 1997. Chairman, Division of Biological Sciences (Depts. of Molecular Oncology,

Cytogenetics, Immunology/Haematology and Electron Microscopy).

1st December 1994 -

31st March 1996. Professor and Head of the Department of Molecular Oncology, Cancer

Institute (WIA) and Muthulakshmi College of Oncological Sciences, Madras, India.

8th October 1991-

26th November 1994. Clinical Research Fellow in the ICRF Molecular Oncology Unit, RPMS,

Hammersmith Hospital, London, UK.

1st April 1990 -

30th November 1994. Reader in the Dept. of Medical Oncology, Cancer Institute (WIA) and

Muthulakshmi College of Oncological Sciences, Madras, India.

1st April 1988-

31st March 1990. Assistant Professor, Dept. of Medical Oncology, Cancer Institute (WIA) and

Muthulakshmi College of Oncological Sciences, Madras, India.

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Prizes and Medals and Awards

1. Johnstone Gold Medal - Best outgoing M.B.B.S student.

2. Col.K.G. Pandalai Charitable - Best outgoing M.B.B.S. student.

Trust Endowment Prize

3. Dr. Senthilnathan Gold Medal - Best outgoing male M.B.B.S. student.

4. Dr.J.A.S. Masilamani Memorial - Highest number of marks in all

Gold Medal University examinations

5. Dr.G. Rama Rao Gold Medal - Anatomy

6. Dr. Rajasekara Reddy Prize - Anatomy

7. Dr. K. Govindareddy Memorial - Highest number of University

Gold Medal examination marks in Anatomy

8. Dr. Sundarareddy Memorial - Highest number of University

Prize examination marks in Anatomy

9. Col.Van Geyzel Prize - Biochemistry

10. Dr.Samuel Jesudoss Prize - Pharmacology

11. Bradfield Prize - Highest number of University examination marks

in Anatomy and Surgery

12. Certificate of Merit- Physiology - Highest number of University examination marks

in Physiology

13. Certificate of Merit- Pharmacology - Highest number of University examination marks

in Pharmacology

14. Nutrition Prize - Essay and Elocution

15. Certificate of Honour - Bacteriology

16. Certificate of Honour - Pharmacology

During M.D. (General Medicine)

17. Dr. Edmund Leorde Chalke Prize - Best Post-graduate in Medicine.

Post D.M.

18. Recipient of the Commonwealth Scholarship for 1991, tenable at Royal Postgraduate

Medical School, Hammersmith Hospital, London, for Cancer Research.

Post-Doctoral

1. Recipient of the Inventor's Award from Imperial Cancer Research Fund, UK.

2. Late Shri Muthuswamy Naidu Memorial Oration, 2006.

3. Elected as a Fellow of the National Academy of Medical Sciences, India (FAMS). - 2007

4. Shri Ramniklal J Kinarivala Cancer Research Award, 2008.

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5. Kobayashi Foundation Award for Cancer Research – 2010.

6. Sir Dorabji Tata Oration – Indian Cancer Congress, Feb 2011

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PUBLICATIONS:

National: 30

International: 56

First author: 33 ; Corresponding author when not first author: 18

LIST OF PUBLICATIONS

1. Krishnamurthy S, Shantha V, Rajkumar T. Drug therapy in oncology - its priority and

economics- the Institute experience. Indian Journal of Cancer Chemotherapy, 10: 73-82,

1988.

2. Rajkumar T* , Hemanthraj E, Venkataraman MS, Sukumaran MS and Shantha V. Primary

splenic lymphoma with pancreatic involvement - A case report. Indian Journal of Cancer

Chemotherapy, 11: 53-55, 1989.

3. Kumar L, Rajkumar T, Raghunath Rao D, Usha Devi CJ, Sagar TG, Shanta V. Intrathecal

methotrexate toxicity. JAPI, 37: 351, 1989.

4. Sagar TG, Maitreyan V, Rajkumar T, Maji U and Shantha V. Primary malignant lymphoma of

the minor salivary gland - A case report. Indian Journal of Cancer Chemotherapy, 12: 71-73,

1990.

5. Rajkumar K, Rajkumar T, Sagar TG, Maitreyan V and Shantha V. Cryptococcal meningitis in

a Hodgkin's lymphoma patient - A case report. JAPI., 40: 707-708, 1991.

6. Shantha V and Rajkumar T. Malignant epithelial tumours of the ovary - concepts in the

diagnosis and management. In: Textbook of Obstetrics and Gynaecology for Postgraduates.

Orient Longmans, vol 1, 364-380, 1992.

7. Rajkumar T* , Maitreyan V, Sagar TG, Vasanthan A, Shastri DVLN and Shantha V. Germ cell

tumour of the ovary - management and results at the Institute. Indian Journal of Cancer, 29:

18-23, 1992.

8. Rajkumar T* , Maitreyan V, Sagar TG, Vasanthan A, Hemanthraj E, Aruna C and Shantha V.

Neo-adjuvant chemotherapy in osteosarcoma - a pilot trial. Indian Journal of Cancer, 29: 139-

142, 1992.

9. Rajkumar T , Gooden CSR, Lemoine NR and Gullick WJ. Expression of c-erbB3 protein in

gastrointestinal tumours as determined by monoclonal antibody RTJ1. J. Pathol., 170: 271-

278, 1993. [IF – 5.121]

10. Sanidas EE, Filipe MI, Linehan J, Lemoine NR, Gullick WJ, Rajkumar T and Levison DA.

Expression of the c-erbB3 gene product in gastric cancer. Int.J.Cancer, 54: 935-940, 1993. [IF

– 4.734]

11. Rajkumar T and Gullick WJ. Type1 growth factor receptors in human breast cancer.

Breast Cancer Research and Treatment, 29: 3-9, 1994. [IF – 5.684]

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12. Sheikh AA, Sagar TG, Maitreyan V, Rajkumar T, Maji U, Shantha V. Secretory

Immunoblastic lymphoma. JAPI, 42: 155-156, 1994.

13. Rajkumar T and Gullick WJ. A monoclonal antibody to the extracellular domain of the

human c-erbB3 protein stimulates the growth of breast tumour cell lines. Br J Cancer, 70:

459-465, 1994. [IF – 4.846]

14. Rajkumar T , Maji U, Mallikarjuna VS, Shantha V and Gullick WJ. c-erbB3 expression in

cervical tumours as determined by the monoclonal antibody RTJ2. Int J Oncol., 6: 105-109,

1995. [IF – 2.234]

15. Rajkumar T , Hollywood DP, Hurst H and Gullick WJ. c-erbB3 expression in breast tumour

derived cell lines. The Breast, 4, 84-91, 1995. [IF – 2.155]

16. Hunt CR, Hale RJ, Armstrong C, Gullick WJ, Rajkumar T, Buckley CH. c-erbB3 proto-

oncogene expression in uterine cervical carcinoma. Int. J. Gynaec. Cancer., 5: 282-285, 1995.

[IF – 1.43]

17. Rajkumar T and Gullick WJ. The type 1 (EGF receptor) growth factor receptor family and

their ligands: their role in human cancers. Waxman, J (ed). Molecular Biology of cancer.

Cambridge University Press, Cambridge, 3-14, 1996.

18. Rajkumar T and Gullick WJ. The production of antibodies to growth factor receptors using

synthetic peptides as immunogens. Jankowski, J A Z and Polak, J M. (eds). Clinical Gene

Analysis and Manipulation: tools, techniques and trouble-shooting. Cambridge University

Press, Cambridge, 99-110, 1996.

19. Rajkumar T , Stamp G, Panda H, Waxman J and Gullick WJ. Type 1 growth factor

receptors in bladder cancer - An immunohistochemical study. J. Pathol., 179: 381-385, 1996.

[IF – 5.121]

20. Nirmala K, Kalaichelvi K, Rajalakshmi KR, Ganapathi Raman S, Van Dongen JJM, Shanta

V, Rajkumar T *. TAL-1 deletion in T-cell acute lymphoblastic leukaemia - Implications in the

detection of minimal residual disease. Indian J Med and Paed Oncology, 17: 79-84, 1996.

21. Rajkumar T , Stamp G, Hughes CM and Gullick WJ. Immunohistochemical analysis of c-

erbB3 protein expression in ovarian carcinomas. J Clin Mol Pathol. 49: M199-M202, 1996. [IF

– 2.324]

22. Pushpa V, Raghunathan K, Majhi U, Pandit RV, Shanthi G, Rajkumar T *. Emperipolesis

- An electron microscopic characteristic in RDD (Rosai-Dorfman Disease) - A case report.

Indian J Med and Paed Oncology, 18, 14-16, 1997.

23. Susheela M, Parameswari E, Rajalakshmi KR, Devarajan S, Shanta V, Rajkumar T*

Cytogenetic studies in ALL - Prognostic implications. Ind. J Haemat & Blood Transfusion,

15,11-15, 1997.

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24. Jayashree B, Deshmukh S, Visalakshi V, Rajalakshmi KR, Sukumaran MS, Moni MS,

Rajkumar T *. Proton Magnetic Resonance spectroscopy of murine fibrosarcoma cell lines.

Ind J Biochem Biophysics , 35, 108-114, 1998. [IF – 0.579]

25. Rajkumar T * , Sharmila R, Majhi U, Selvaluxmi G, Vasanthan A, Shanta V. Bcl-2 and p53

expression in stage IIB and IIIB cervical cancers. Eur J Gynecol Oncol , 19, 556-560, 1998.

[IF – 0.59]

26. Jayashree B, Deshmukh S, Rajkumar T*. Assessment of human sarcoma tissues by

proton NMR spectroscopy: correlation with histopathology. Current Science , 77,(4), 587-592,

1999. [IF – 0.8]

27. Jayashree B, Rajalakshmi KRR, Deshmukh S, Rajkumar T*. Two dimensional NMR

spectroscopic study of fibroblast and fibrosarcoma cell lines. Current Science, 77,(5), 706–

709, 1999. [IF – 0.8]

28. Rajkumar T * and Vijayalakshmi. Molecular studies in cervical cancer. Proceedings of the

XV Asia Pacific Cancer Conference, Published as a Supplementary issue of the Asian and

Pacific Journal of Cancer Prevention, 1, 15-17, 2000.

29. Hemanth Raj E, Skinner A, Majhi U, Nirmala K, Ravichandran K, Shanta V, Hurst H,

Gullick WJ, Rajkumar T. Neuregulin 1- Alpha Expression In Locally Advanced Breast Cancer.

The Breast, 10, 41-45, 2001 . [IF – 2.155]

30. Rajkumar T* . Growth factor and growth factor receptors. Current Science; 81: 535-541,

2001. [IF – 0.8]

31. Nirmala K., Rajalekshmy K. R., G Raman. S., Shanta,V and Rajkumar T. PCR-

Heteroduplex analysis of TCR , and Tal-1 deletions in T-Acute Lymphoblastic leukemias:

Implications in the detection of Minimal Residual Disease. Leukemia Research,Vol.26 (4), 335-

43, 2002. [IF – 2.390]

32. Vijayalakshmi N, Selvaluxmi G, Mahji U and Rajkumar T*. c-Myc oncoprotein expression

and prognosis in patients with carcinoma cervix - An immunohistochemical study”. Eur.J

Gynaecol Oncol. 23(2) 135-38, 2002. [IF – 0.59]

33. Balaram P, Sridhar H, Rajkumar T, Vaccarella S, Herrero R, Nanadakumar A,

Gajalakshmi V, Ravichandran K, Ramdas K, Sankaranaray anan R, Munoz N, Franceschi S.

Oral cancer in Southern India: the influence of smoking, drinking, paan-chewing and oral

hygiene. Int J Cancer, 98, 440-445, 2002. [IF – 4.734]

34. Rajkumar T* and Vijayalakshmi N. Is there a role for surrogate markers of pre-malignant

lesions of cervix in India? Proc. Indian Natl Sci Acad. B69 (1), 73-82, 2003.

35. Rajkumar T , Sridhar H, Balaram P, Vaccarella S, Gajalakshmi V, Nanadakumar A,

Ramdas K, Munoz N, Herrero R, Franceschi S and Weiderpass E. Oral cancer in Southern

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India: The influence of body size, diet, infections and sexual practices. Eur. J. Cancer

Prevention, 12, 135-143, 2003. [IF – 1.865]

36. Rajkumar T , Franceschi S, Vaccarella S, Gajalakshmi V, Sharmila A, Snijders PFJ,

Munoz N, Meijer CJL, Herrero R. The role of paan chewing and dietary habits in cervical

carcinoma in Chennai, India. Br J Cancer, 88: 1388-1393, 2003. [IF – 4.846]

37. Franceschi S, Rajkumar T, Vaccarella S, Gajalakshmi V, Sharmila A, Snijders PFJ,

Munoz N, Meijer CJL, Herrero R. Human papilloma virus and risk factors for cervical cancer in

Chennai, India: A case control study. Int. J Cancer, 107: 127-133, 2003. [IF – 4.734]

38. Rajkumar T* , Soumittra N, Nirmala Nancy, Swaminathan R, Sridevi V, Shanta V BRCA1,

BRCA2 and CHEK2 (1100 del C) germline mutations in hereditary breast and ovarian cancer

families in South India. Asian Pac J Cancer Prevent. 4: 203-208, 2003.

39. Nirmala Nancy and Rajkumar T* Detection of minimal residual disease in ALL. Lalit

Kumar ed., Progress in Haematologic Oncology. The Advanced Research Foundation, New

York. 45-60, 2003.

40. Herrero R, Castellsague X, Pawlita M, Lissowska J, Kee F, Balaram P, Rajkumar T,

Sridhar H, Rose B, Pintos J, Fernandez L, Idris A, Martinez C, Nieto A, Talamini R, Tavani A,

Bosch FX, Snijders PJF, Viscidi R, Munoz N, Franceschi S. The viral etiology of oral cancer:

evidence from the IARC multicentric study. JNCI. 95:1772-1783, 2003. [IF – 14.933]

41. Rajkumar T*. Molecular mechanisms of cancer. Dr.V.Shanta & Dr.T.Rajkumar ed.,

Postgraduate Oncology Update, Indian Journal of Clinical Practice, 31-41, 2004.

42. Rajkumar T*. Hereditary cancers. Dr.V.Shanta & Dr.T.Rajkumar ed., Postgraduate

Oncology Update, Indian Journal of Clinical Practice, 84-95, 2004.

43. Rajkumar T* , Soumittra N, Durgatosh Pandey, Karunakaran Nirmala Nancy, Vikas

Mahajan and Urmila Majhi. Mutation analysis of hMSH2 and hMLH1 in colo-rectal cancer

patients in India. Genetic Testing, 8:157-162, 2004. [IF – 1.22]

44. Min Dai, Gary M. Clifford, Florence le Calvez, Xavier Castellsagué, Peter J. F. Snijders,

Michael Pawlita, Rolando Herrero, Pierre Hainaut and Silvia Franceschi for the IARC

Multicenter Oral Cancer Study Group (In addition to the authors, the following investigators

contributed to the study: Nubia Muñoz, IARC, Lyon, France; Javier Pintos, McGill University,

Montreal, Canada; Frank Kee, Queen’s University Belfast, Northern Ireland, United Kingdom;

Leticia Fernandez, Instituto Nacional de Oncologia y Radiobiologia, La Habana, Cuba; Chris J.

L. M. Meijer, Vrije Universiteit Medical Center, Amsterdam, the Netherlands; Ali Idris, Toombak

and Smoking Research Center, Khartoum, the Sudan; María José Sánchez, Escuela Andaluza

de Salud Publica, Granada, Spain; Adoracion Nieto, Facultad de Medicina, Sevilla, Spain; F.

Xavier Bosch, Institut Català d’Oncologia, Barcelona, Spain; Renato Talamini, Centro di

Riferimento Oncologico di Aviano, Aviano, Italy; Alessandra Tavani, Instituto di Ricerche

8

Farmacologiche "Mario Negri," Milan, Italy; Ulrich Reidel, Deutsches Krebsforschungszentrum,

Heidelberg, Germany; Jolanta Lissowska, Cancer Center, Warsaw, Poland; Barbara Rose,

Sydney Head and Neck Cancer Institute, Royal Prince Alfred Hospital, Sydney Australia;

Hema Sridhar, Kidwai Memorial Institute of Oncology, Bangalore, India; Prabda Balaram,

Regional Cancer Center, Trivandrum, India; Thangarajan Rajkumar, Cancer Institute (WIA),

Chennai, India; Raphael Viscidi, Stanley Division of Developmental Neurovirology, Johns

Hopkins University School of Medicine Baltimore, Maryland). Human Papillomavirus Type 16

and TP53 Mutation in Oral Cancer Matched Analysis of the IARC Multicenter Study. Cancer

Res 64, 468-471, 2004. [IF – 7.514]

45. G Gopal and Rajkumar T*. Variant of mitochondrial ribosomal protein s28 (mrps28) gene

is differentially expressed in response to radiation in a cervical carcinoma derived cell line. Ind

J Biochem Biophysics, 42: 81-86, 2005. [IF – 0.579]

46. T. Parija, S. Shirley, S. Uma, K.R Rajalekshmy, S. Ayyappan, T. Rajkumar *. Type 1 (11;

22)(q24: q12) translocation is common in Ewing’s sarcoma / PNET in south Indian patients. J

Biosciences 30(3), 371-376, 2005. [IF – 1.703]

47. Aimée R. Kreimer , Gary M. Clifford, Peter J.F. Snijders, Xavier Castellsagué, Chris J.L.M.

Meijer, Michael Pawlita, Raphael Viscidi, Rolando Herrero, Silvia Franceschi, for the

International Agency for Research on Cancer (IARC) Multicenter Oral Cancer Study Group.

[The following investigators contributed to the study: Nubia Muñoz, IARC, Lyon, France; Javier

Pintos, McGill University, Montreal, Canada; Frank Kee, Queen's University Belfast, Belfast,

Northern Ireland, United Kingdom; Leticia Fernández, Instituto Nacional de Oncología y

Radiobiología, Havana, Cuba; Ali Idris, Toombak and Smoking Research Center, Khartoum,

the Sudan; María José Sánchez, Escuela Andaluza de Salud Pública, Granada, Spain;

Adoración Nieto, Facultad de Medicina, Seville, Spain; F. Xavier Bosch, Institut Català

d'Oncologia, Barcelona, Spain; Renato Talamini, Centro di Riferimento Oncologico di Aviano,

Aviano, Italy; Alessandra Tavani, Instituto di Ricerche Farmacologiche Mario Negri , Milan,

Italy; Ulrich Reidel, Deutsches Krebsforschungszentrum, Heidelberg, Germany; Jolanta

Lissowska, Cancer Center, Warsaw, Poland; Barbara Rose, Sydney Head and Neck Cancer

Institute, Royal Prince Alfred Hospital, Sydney, Australia; Hema Sridhar, Kidwai Memorial

Institute of Oncology, Bangalore, India; Prabha Balaram, Regional Cancer Centre,

Trivandrum, India; Thangarajan Rajkumar, Cancer Institute (WIA), Chennai, India.] HPV16

semiquantitative viral load and serologic biomarkers in oral and oropharyngeal squamous cell

carcinomas. Int J Cancer 115, 329-332, 2005. [IF – 4.734]

48. Rajkumar T* , Gopal G, Selvaluxmi G and K.R.Rajalekshmy. CDC27 is involved in

radiation response in squamous cell carcinoma of the cervix. Ind J Biochem Biophysics 45,

271-278, 2005. [IF – 0.579]

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49. Rajkumar T* , Soumittra N, Vidubala E, Sridevi V, Mahajan V, Ramanan SG, Vijaya S.

Organization and running of the first comprehensive hereditary cancer clinic in India.

Hereditary Cancer in Clinical Practice 3(4) pp. 165-170, 2005. [IF – 1.18]

50. Kreimer AR, Randi G, Herrero R, Castellsagué X, La Vecchia C, Franceschi S; IARC

Multicenter Oral Cancer Study Group. Diet and body mass, and oral and oropharyngeal

squamous cell carcinomas: analysis from the IARC multinational case-control study.

Int J Cancer. 2006 May 1;118(9):2293-7. [IF – 4.734]

51. International Collaboration of Epidemiological Studies of Cervical cancer [Analysis

and writing committee: P Appleby, V Beral, A Berrington de González, D Colin, S Franceschi,

J Green, C La Vecchia, J Peto, M Plummer, G Randi, S Sweetland.

Steering committee: FX Bosch, R Herrero, A Hildesheim, C La Vecchia (chairman), D Skegg,

D Thomas.

Collaborators: Cancer Institute (WIA), Chennai, India: T Rajkumar; Cancer Research UK

Epidemiology Group, Wolfson Institute of Preventive Medicine, London, UK: J Cuzick; Cancer

Research UK Epidemiology Unit, Oxford, UK: P Appleby, R Barnabas, V Beral, A Berrington

de González, D Bull, K Canfell, B Crossley, J Green, G Reeves, S Sweetland; Danish Cancer

Society, Copenhagen, Denmark: S Kjaer; Unit of Health Care Epidemiology, Oxford, UK: R

Painter, M Vessey; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA: J

Daling, M Madeleine, R Ray, D Thomas; Guanacaste Epidemiological Project, San José,

Costa Rica: R Herrero; Department of Medical Epidemiology and Biostatistics, Karolinska

Institut, Stockholm, Sweden: N Ylitalo; Epidemiology and Cancer Registration Unit, IDIBELL,

Institut Català d'Oncologia, Barcelona, Spain: FX Bosch, S de Sanjosé, X Castellsagué, V

Moreno; Institut Nacional de Santé Publique, Algiers, Algeria: D Hammouda; Istituto di

Ricerche Farmacologiche Mario Negri , Milan, Italy: E Negri, G Randi; Instituto Especializado

de Enfermedades Neoplásicas Dr Eduardo Cáceres Graziani , Lima, Peru: M Alvarez, O

Galdos, C Santos, C Velarde; International Agency for Research on Cancer, Lyon, France: D

Colin, S Franceschi, N Muñoz, M Plummer; London School of Hygiene and Tropical Medicine,

London and Institute of Cancer Research, Sutton, UK: J Peto; Lund University, Mälmo,

Sweden: J Dillner, I Silins; Ministere de la Santé Publique et des Affaires Sociales, Bamako,

Mali: S Bayo; Ministry of Health, Rabat, Morocco: N Chaouki; Ministry of Health, Asunción,

Paraguay: PA Rolón; National Cancer Institute, NIH, Bethesda, Maryland, USA: L Brinton, A

Hildesheim, J Lacey Jr, M Schiffman; Cancer Epidemiology Research Group, National Health

Laboratory Service, Johannesburg, South Africa: L Stein, MI Urban; Royal College of General

Practitioners Oral Contraception Study, UK: P Hannaford; Prince of Songkla University,

Songkla, Thailand: SB Chichareon; The Cancer Council New South Wales, Sydney, Australia:

F Sitas; Universidade de São Paulo, São Paulo, Brazil: J Eluf-Neto; University of Milan, Milan,

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Italy: C La Vecchia; University of Otago, Dunedin, New Zealand: D Skegg; University of

Southern California, Los Angeles, California, USA: R Peters, M Pike, G Ursin; University of the

Philippines, Manila, The Philippines: C Ngelangel; University of Tromsø, Tromsø, Norway: IT

Gram; World Health Organisation, Geneva, Switzerland: T Farley, O Meirik.]. Cervical

carcinoma and reproductive factors: collaborative reanalysis of individual data on 16,563

women with cervical carcinoma and 33,542 women without cervical carcinoma from 25

epidemiological studies. Int J Cancer. 2006 Sep 1;119(5):1108-24. [IF – 4.734]

52. International Collaboration of Epidemiological Studies of Cervical cancer.

Carcinoma of the cervix and tobacco smoking: Collaborative reanalysis of individual data on

13,541 women with carcinoma of the cervix and 23,017 women without carcinoma of the

cervix from 23 epidemiological studies. Int J Cancer. 2006 Mar 15;118(6):1481-95. [IF – 4.734]

53. Xavier Castellsagué, Mireia Díaz, Silvia de Sanjosé, Nubia Muñoz, Rolando Herrero,

Silvia Franceschi, Rosanna W. Peeling, Rhoda Ashley, Jennifer S. Smith, Peter J. F. Snijders,

Chris J. L. M. Meijer, F. Xavier Bosch For the International Agency for Research on Cancer

Multicenter Cervical Cancer Study Group. Worldwide Human Papillomavirus Etiology of

Cervical Adenocarcinoma and Its Cofactors: Implications for Screening and Prevention. JNCI

Journal of the National Cancer Institute 2006 98(5):303-315. [The IARC Multi-center Cervical

Cancer Study Group includes the following additional researchers: M. Plummer (IARC, Lyon),

France; V. Moreno (Institut Català d'Oncologia, Barcelona), Spain; P. Alonso de Ruiz (General

Hospital of Mexico, Mexico), Mexico; S. Chichareon (Prince of Songkla University, Hat-Yai),

Thailand; C. Ngelangel (University of the Philippines, Manila), The Philippines; J. Eluf-Neto

(Universidade de Sao Paulo, Sao Paulo), Brazil; P. A. Rolón (Laboratorio de Anatomia

Patológica y Citologia, Asunción), Paraguay; E. Caceres and C. Santos (Maes Heller Cancer

Research Institute, Lima), Peru; N. Chaouki and B. El Gueddari (Institut National d'Oncologie,

Rabat), Morocco; D. Hammouda (Institut National de Santé Publique, Département Contrôle

des Maladies, Alger), Algeria; T. Rajkumar (Cancer Institute, Adyar, Chennai), India.] [IF –

14.933]

54. Quint WG, Pagliusi SR, Lelie N, de Villiers EM, Wheeler CM; World Health Organization

Human Papillomavirus DNA International Collaborative Study Group. Members of the WHO

HPV DNA International Collaborative Study Group are as follows: F.M. Buonaguro, Istituto

Nazionale Tumori, Laboratory of Viral Oncology and AIDS, Naples, Italy; R. D. Burk, Cancer

Research Center, Albert Einstein College of Medicine, New York, N.Y.; C. Clavel, Laboratoire

Pol Bouin, Unite´ de Biologie Cellulaire, Reims, France; J. Cuzick, Cancer Research UK,

Department of Epidemiology/Mathematics and Statistics, London, United Kingdom; B. C. Das,

M. K. C. G. Medical College, Department of Social and Preventive Medicine, Berhampur,

India; J. Dillner, Lund University, Malmo University Hospital, Malmo, Sweden; S. M. Garland,

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Royal Women’s and Royal Children’s Hospitals, Department of Microbiology and Infectious

Diseases, Melbourne, Australia; P. Gravitt, Johns Hopkins Bloomberg School of Public Health,

Baltimore, Md.; T. Iftner, Universita¨tsklinikum Tuebingen, Institut fur Medizinische Virologie,

Tuebingen, Germany; R. Kelkar, Tata Memorial Hospital, Department of Microbiology,

Mumbai, India; M. von Knebel Doeberitz, University of Heidelberg, Division of Molecular

Diagnostics and Therapy, Heidelberg, Germany; J. Kornegay, Roche Molecular Systems Inc.,

Alameda, Calif.; A. T. Lorincz, Digene Corporation, Gaithersburg, Md.; B. Lloveras Rubio,

Institut Catala` d’Oncolgia, Barcelona, Spain; M.-T. Martin, GlaxoSmithKline, Rixensart,

Belgium; C. Meijer, Academic Hospital Veije University, Amsterdam, The Netherlands; J. S.

Park, Kangnam St. Mary’s Hospital, Catholic University Medical College, Seoul, Republic of

South Korea; S. N. Park, Korea Food and Drug Administration, Division of Viral Products

Korea FDA, Seoul, Republic of South Korea; W. Quint, Delft Diagnostic Laboratory, Delft, The

Netherlands; T. Rajkumar, Cancer Institute, Department of Molecular Oncology, Chennai,

India; R. Sahli, Institut de Microbiologie, Lausanne, Switzerland; L. L. Villa, Instituto Ludwig de

Pesquisa sobre o Cancer, Sao Paolo, Brazil; C. Wheeler, University of New Mexico,

Department of Molecular Genetics and Microbiology, Albuquerque, N. Mex.; and A. L.

Williamson, University of Cape Town, National Health Laboratory Service and Institute of

Infectious Disease and Molecular Medicine, Cape Town, South Africa. Results of the first

World Health Organization international collaborative study of detection of human

papillomavirus DNA. J Clin Microbiol. 2006 Feb;44(2):571-9. [IF – 3.945]

55. Sudhakar N, Nirmala K Nancy, Rajalekshmy KR, Raman SG, Rajkumar T . T-cell receptor

gamma and delta gene rearrangements and junctional region characteristics in south Indian

patients with T-cell acute lymphoblastic leukemia. Am J Hematol. 2007 Mar;82(3):215-21. [IF –

2.126]

56. Uma Ramanathan S. and Rajkumar T*. DNA Microarray and breast cancer – A review.

International Journal of Human Genetics.2007, March, 7(1), 49-56.

57. International Collaboration of Epidemiological Studies of Cervical cancer.

Comparison of risk factors for invasive squamous cell carcinoma and adenocarcinoma of the

cervix: collaborative reanalysis of individual data on 8,097 women with squamous cell

carcinoma and 1,374 women with adenocarcinoma from 12 epidemiological studies. Int J

Cancer. 2007 Feb 15;120(4):885-91. [IF – 4.734]

58. M.Samson, R.Swaminathan, R.Rama, V.Sridevi, K.Nirmala Nancy, T.Rajkumar*. Role of

GSTM1 (Null/Present), GSTP1 (Ile105Val) and p53 (Arg72Pro) genetic polymorphisms and

the risk of breast cancer – A case control study from South India. Asian Pacific J Cancer

Prevention, 2007, 8(2):253-7.

12

59. Christine Weyna, Selma Boulenouara, Vanessa Mathysb, Julie Vanhoolandta, Aurore

Bernisa, Véronique Fontainea,* and the RIIP and INCTR Workshop Study Groupc. The “RIIP

and INCTR Workshop Study Group” is composed of the following institutions and

investigators: Pasteur Institute of French Guiana, Laboratory of Virus-Host Interactions: Dr.

Vincent Lacoste, Pasteur Institute of Madagascar, Laboratory of Pathology: Dr. Clairette

Raharisolo Vololonantenaina, Stephan Angeloff Institute of Microbiology, Department of

Virology, Bulgaria : Dr. Angel S. Galabov and Peter Grozdanov, Cancer Institute (WIA),

Department of Molecular Oncology, Chennai, India: Dr. Tithi Parija and Dr. Thangarajan

Rajkumar, National Institute of Hygiene and Epidemiology, Hanoï, Vietnam: Dr. Nguyen Thi

Thuong, Pasteur Institute of Tunisia, Laboratory of Pathology: Dr. Haifa Tounsi-Guettiti, Dr.

Samir Boubaker and Dr. Emna Jerbi, Pasteur Institute of Cambodia, Laboratory of Pathology :

Dr. Didier Monchy, Cantacuzino Institute, unit HPV, Bucharest, Romania : Dr. Niculina Coman,

Tata Memorial Hospital, Department Microbiology: Preethi Vijayan, Pasteur Institute of

Morocco, Laboratory of Molecular Biology : Dr. Abdelouaheb Bennani, Pasteur Institute of

Ivorian Coast, Sexually transmitted Diseases Laboratory: Dr. Hortense Faye-Ketté and Dr.

Mireille Dosso. Detection of human papillomavirus types 45 and 51 by type-specific

polymerase chain reaction. J Virol Methods, 2007, 146: 405-08. [IF – 2.077]

60. International Collaboration of Epidemiological Studies of Cervical Cancer. Analysis

and writing committee: Paul Appleby, Valerie Beral, Didier Colin, Amy Berrington de González,

Silvia Franceschi, Jane Green, Julian Peto, Martyn Plummer, Siân Sweetland. Steering

committee: Carlo La Vecchia (Chairman), Xavier Bosch, Rolando Herrero, Allan Hildesheim,

David Skegg, David Thomas. Collaborators: Cancer Epidemiology Research Group, National

Health Laboratory Service, Johannesburg, South Africa: L Stein, MI Urban. Cancer Institute

(WIA), Chennai, India: T Rajkumar. Cancer Research UK Epidemiology Group, Wolfson

Institute of Preventive Medicine, UK: J Cuzick. Cancer Research UK Epidemiology Unit,

Oxford, UK: P Appleby, R Barnabas, V Beral, A Berrington de González, D Bull, K Canfell, J

Green, G Reeves, S Sweetland. Danish Cancer Society, Denmark: S Kjaer. Department of

Public Health, Oxford, UK: R Painter, M Vessey. Fred Hutchinson Cancer Research Center,

Seattle, USA: J Daling, M Madeleine, R Ray, D Thomas. Guanacaste Epidemiological Project,

Costa Rica: R Herrero. Department of Medical Epidemiology and Biostatistics, Karolinska

Institut, Sweden: N Ylitalo. Institut Català d’Oncologia: FX Bosch, X Castellsagué. Institut

Nacional de Santé Publique, Algiers, Algeria: D Hammouda. Institute of Cancer Research,

Sutton, UK, and London School of Hygiene and Tropical Medicine, London, UK: J Peto.

Instituto Nacional de Enfermedades Neopláscias ‘Dr Eduardo Caceres Grazini’, Lima, Peru: C

Santos. International Agency for Research on Cancer, Lyon, France: D Colin, S Franceschi, N

Muñoz, M Plummer. Istituto di Ricerche Farmacologiche ‘Mario Negri’, Milan, Italy: C La

13

Vecchia, E Negri. Lund University, Mälmo, Sweden: J Dillner, I Silins. Ministere de la Sante

Publique et d’Affaires Sociales, Bamako, Mali: S Bayo. Ministry of Health, Morocco: N

Chaouki. Ministry of Health, Paraguay: P Rolon. National Cancer Institute, NIH, USA: L

Brinton, A Hildesheim, J Lacey Jr, M Schiffman. Royal College of General Practitioners Oral

Contraception Study, UK: P Hannaford. Prince of Songkla University, Songkla, Thailand: S

Chichareon. The Cancer Council New South Wales, Sydney Australia: F Sitas. Universidade

de São Paulo, Brazil: J Eluf-Neto. University of Milan, Italy: C La Vecchia. University of Otago,

New Zealand: D Skegg. University of Southern California, USA: M Pike, G Ursin. University of

the Philippines, Manila, The Philippines: C Ngelangel. University of Tromsø, Norway: I T

Gram. World Health Organisation, Geneva: T Farley. Cervical cancer and hormonal

contraceptives: collaborative reanalysis of individual data on 16,573 women with cervical

cancer and 35,509 women without cervical cancer from 24 epidemiological studies. Lancet,

2007, 370(9599): 1609-1621. [IF – 28.409]

61. Vijayalakshmi N, Selvaluxmi G, Majhi U and Rajkumar T*. Alterations found in

p16/RB/Cyclin D1 pathway in the dysplastic and malignant cervical epithelium. Oncology

Research, 2007, 16(11), 527-533. [IF - 1.35]

62. Doherty R, Lubinski J, Manguoglu E, Luleci G, Christie M, Craven P, Bancroft E, Mitra A,

Morgan S, Eeles R; IMPACT steering committee and collaborators. † Abele A (Latvia); Altree

M (Australia); Anagnostopoulos T (Greece); Ardern-Jones A (UK); Arver B (Sweden); Bancroft

E (UK); Bangma C (The Netherlands); Bartsch G (Austria); Benitez J (Spain); Bevilacqua G

(Italy); Blanco I (Spain); Bratt O (Sweden); Brewer C (UK); Brohet R (The Netherlands);

Caldes T (Spain); Caligo M (Italy); Chang-Claude J (Germany); Chapman C (UK); Chenevix-

Trench G (Australia); Clowes V (UK); Cole T (UK); Cook J (UK); Cook M (UK); Cooper C (UK);

Copakova L (Slovakia); Cruger D (Denmark); Cummings C (UK); Davidson R (UK); Dearneley

D (UK); Donaldson A (UK); Dorkins H (UK); Douglas F (UK); Easton D (UK); Eccles D (UK);

Eeles R (UK); Evans G (UK); Everaus H (Estonia); Eyfjord J (Iceland); Falconer A (UK); Fisher

C (UK); Foster C (UK); Friedman E (Israel); Furhauser C (Austria); Gardovskis J (Latvia);

Gerdes A-M (Denmark); Goldgar D (USA); Gregory H (UK); Grönberg H (Sweden); Haites N

(UK); Hamdy F (UK); Heimdahl K (Norway); Hodgson S (UK); Ilencikova D (Slovakia); Irmejs A

(Latvia); Izatt L (UK); Jóhannsson O (Iceland); Khoo V (UK); Kiemeny B (The Netherlands);

Korn V (Austria); Kote-Jarai Z (UK); Kyriacou K (Cyprus); Lilja H (USA); Lilleby W (Norway);

Lindeman G (Australia); Loman N (Sweden); Lubinski J (Poland); Luedtke-Heckenkamp K

(Germany); Luleci G (Turkey); Lyubchenko L (Russia); Mæhle L (Norway); Male A (UK);

Manguoglu E (Turkey); Melia J (UK); Mitchell G (Australia); Mitra A (UK); Moller P (Norway);

Moynihan C (UK); Nansalmaa M (Mongolia); Nicolai N (Italy); Olah E (Hungary); Olsson H

(Sweden); Osorio A (Spain); Osther P (Denmark); Ozbek U (Turkey); Papp J (Hungary);

14

Paterson J (UK); AM, Peock S (UK); Peris M (Spain); Pichert G (UK); Radice P (Italy);

Rajkumar T (India); Rennert G (Israel); Rookus M (The Netherlands); Salmon A (Israel);

Schmutzler R (Germany); Schröder F (The Netherlands); Segura P (Spain); Sibley P (UK);

Side L (UK); Stapleton A (Australia); Stratton M (UK); Suri M (UK); Suthers G (Australia);

Taylor L (Australia); Thompson A (UK); Valdagni R (Italy); van Asperen C (The Netherlands);

van Leeuwen F (The Netherlands); Vasen H (The Netherlands); Wagner T (Australia); Wilson

P (UK); Yannoukakos D (Greece); Young M-A (Australia). Short report. The AIDIT and

IMPACT conference 2006: Outcomes and future directions. Hered Cancer Clin Pract. 2007

Mar 15;5(1):53-5.

63. Rajkumar T * and Yamuna M. Multiple pathways are involved in drug resistance to

doxorubicin in an osteosarcoma cell line. Anti-Cancer Drugs, 2008, 19(3): 257-265 . [IF -

2.358]

64. T.Rajkumar *, M.Samson, R.Rama, V.Sridevi, U.Mahji, R.Swaminathan, N.K.Nancy.

TGFβ1 (LEU10PRO), p53 (ARG72PRO) can predict for increased risk for breast cancer in

south indian women and TGFβ1 PRO (LEU10PRO) allele predicts response to neo-adjuvant

chemo-radiotherapy. Breast Cancer Res and Treat. 2008, 112(1):81-87. [IF – 5.684]

65. Sridevi V and Rajkumar T*. Genetics and Genomics of ovarian cancer. Chapter in Book

titled “Ovarian Cancer - comprehensive and contemporary management",

Jaypee Brothers,New Delhi, 2008, Editors: K Chitrathara, Shalini Rajaram, Amita

Maheshwari. 

66. Murhekar K, Majhi U, Sridevi V, Rajkumar T. Does "ichthyosis uteri" have malignant

potential? : A case report of squamous cell carcinoma of endometrium associated with

extensive ichthyosis uteri. Diagn Pathol. 2008 Jan 31;3(1):4 . [IF – 1.11]

67. N Sudakar, Nirmala KA, Rajalekshmy KR, Rajkumar T. Does TAL-1 Deletion Contribute

to the High Incidence of T-Cell Acute Lymphoblastic Leukemia in South Indian Patients? Asian

Pac J Cancer Prev. 2008 Jan-Mar;9(1):127-30.

68. Boyle P, Anderson BO, Andersson LC, Ariyaratne Y, Auleley GR, Barbacid M, Bartelink

H, Baselga J, Behbehani K, Belardelli F, Berns A, Bishop J, Brawley O, Burns H, Clanton M,

Cox B, Currow D, Dangou JM, de Valeriola D, Dinshaw K, Eggermont A, Fitzpatrick J,

Forstmane M, Garaci E, Gavin AT, Kakizoe T, Kasler M, Keita N, Kerr D, Khayat D, Khleif S,

Khuhaprema T, Knezevic T, Kubinova R, Mallath M, Martin-Moreno J, McCance D, McVie JG,

Merriman A, Ngoma T, Nowacki M, Orgelbrand J, Park JG, Pierotti M, Ashton LP, Puska P,

Escobar CV, Rajan B, Rajkumar T, Ringborg U, Robertson C, Rodger A, Roovali L, Santini

LA, Sarhan M, Seffrin J, Semiglazov V, Shrestha BM, Soo KC, Stamenic V, Tamblyn C,

Thomas R, Tuncer M, Tursz T, Vaitkiene R, Vallejos C, Veronesi U, Wojtyla A, Yach D, Yoo

15

KY, Zatonski W, Zaridze D, Zeng YX, Zhao P, Zheng T. Need for global action for cancer

control. Ann Oncol. 2008 Sep;19(9):1519-21. [IF – 4.935]

69. Sasikala P S, Nirmala K, Shirley S, Majhi U, Rajkumar T (2008) Frequency and

distribution of EBV infection and its association with P53 expression in a series of

primary nodal NHL patients from South India. International J of Laboratory Hematology. (Epub

Dec 4, 2008). 2010;32(1 Pt 2):56-64 [IF – 1.0].

70. Suneetha KJ, Nirmala Nancy K, Rajalekshmy KR, Sagar TG, Rajkumar T. Role of

GSTM1 and GSTP1 (Ile105Val) polymorphisms in susceptibility to acute lymphoblastic

leukaemia among south Indian population. Asian Pacific J Cancer Prev, 2008, 9, 733-736.

71. International Collaboration of Epidemiological Studies of Cervical Cancer. Analysis

and writing committee‡: Paul Appleby, Valerie Beral, Amy Berrington de González, Didier

Colin, Silvia Franceschi, Jane Green, Carlo La Vecchia, Julian Peto, Martyn Plummer§, Sian

Sweetland. Steering committee: F Xavier Bosch, Rolando Herrero, Allan Hildesheim, Carlo La

Vecchia (chairman), David Skegg, David Thomas. Collaborators: Cancer Institute (WIA),

Chennai, India: T Rajkumar. Cancer Research UK Epidemiology Group, Wolfson Institute of

Preventive Medicine, London, UK: J Cuzick. Cancer Research UK Epidemiology Unit, Oxford,

UK: P Appleby, V Beral, A Berrington de González, D Bull, K Canfell, B Crossley, J Green, G

Reeves, S Sweetland. Danish Cancer Society, Copenhagen, Denmark: S Kjaer. Unit of Health

Care Epidemiology, Oxford, UK: R Painter, M Vessey. Fred Hutchinson Cancer Research

Center, Seattle, Washington, USA: J Daling, M Madeleine, R Ray, D Thomas. Guanacaste

Epidemiological Project, San José, Costa Rica: R Herrero. Department of Medical

Epidemiology and Biostatistics, Karolinska Institut, Stockholm, Sweden: N Ylitalo.

Epidemiology and Cancer Registration Unit, IDIBELL, Institut Català d’Oncologia, Barcelona,

Spain: FX Bosch, X Castellsagué, S de Sanjosé, K Louie, V Moreno. Institut Nacional de

Santé Publique, Algiers, Algeria: D Hammouda. Istituto di Ricerche Farmacologiche ‘Mario

Negri’, Milan, Italy: E Negri. Instituto Especializado de Enfermedades Neoplásicas ‘Dr Eduardo

Cáceres Graziani’, Lima, Peru: M Alvarez, O Galdos, C Santos, C Velarde. Instituto Nacional

de Cancerología, Bogata, Colombia: N Muñoz. International Agency for Research on Cancer,

Lyon, France: D Colin, S Franceschi, M Plummer. London School of Hygiene and Tropical

Medicine, London and Institute of Cancer Research, Sutton, UK: J Peto. Lund University,

Mälmo, Sweden: J Dillner, I Silins. Ministère de la Santé Publique et des Affaires Sociales,

Bamako, Mali: S Bayo. Ministry of Health, Rabat, Morocco: N Chaouki. Ministry of Health,

Asunción, Paraguay: PA Rolón. National Cancer Institute, NIH, Bethesda, Maryland, USA: L

Brinton, A Hildesheim, J Lacey Jr, M Schiffman. Cancer Epidemiology Research Group,

National Health Laboratory Service, Johannesburg, South Africa: L Stein, MI Urban. Royal

College of General Practitioners Oral Contraception Study, UK: P Hannaford. Prince of

16

Songkla University, Songkla, Thailand: SB Chichareon. The Cancer Council New South

Wales, Sydney, Australia: F Sitas. Universidade de São Paulo, São Paulo, Brazil: J Eluf-Neto.

University of Milan, Milan, Italy: C La Vecchia. University of Otago, Dunedin, New Zealand: D

Skegg. University of Southern California, Los Angeles, California, USA: R Peters, M Pike, G

Ursin. University of the Philippines, Manila, The Philippines: C Ngelangel. University of

Tromsø, Tromsø, Norway: IT Gram. World Health Organisation, Geneva, Switzerland: T

Farley, O Meirik. Cervical carcinoma and sexual behaviour: collaborative reanalysis of

individual data on 15,461 women with cervical carcinoma and 29,164 women without cervical

carcinoma from 21 epidemiological studies. Cancer Epidemiology Biomarkers and Prevention.

2009, 18: 1060-9. [IF – 4.770]

72. M. Samson , R. Rama , R. Swaminathan , V. Sridevi, K. N. Nancy, T. Rajkumar*. CYP17

(T-34C), CYP19 (Trp39Arg), and FGFR2 (C-906T) polymorphisms and the risk of Breast

Cancer in South Indian Women Population. Asian Pacific J Cancer Prev, 2009, 10: 111-4.

73. T. Rajkumar *, Priya . Phase-1 clinical trial of dendritic cell vaccines for human

papillomavirus positive cervical cancer. G.P.Talwar and O.P.Sood ed., Treatment of advanced

stage cancers, Narosa Publishing House, New Delhi, 2009, 140-141.

74. T.Rajkumar. Hereditary Ovarian cancers. Indian J Medical Paediatric Oncology, 2009,

30: 48.

75. Lavanya Nambaru, Balaiah Meenakumari, Rajaraman Swaminathan, Thangarajan

Rajkumar*. Prognostic significance of HPV physical status and HPV integration sites in

cervical cancer. APJCP, 2009,10: 355-60.

76. Nagaswamy Soumittra, Balaiah Meenakumari, Tithi Parija, Veluswami Sridevi,

Karunakaran Nirmala Nancy, Rajaraman Swaminathan, Kamalalayam Raghavan

Rajalekshmy, Urmila Majhi, Thangarajan Rajkumar *. Molecular Genetics Analysis of

Hereditary Breast and Ovarian Cancer Patients in India. Hereditary Cancer in Clinical Practice

2009, 7:13. [IF – 1.18]

77. Franceschi S, Plummer M, Clifford G, de Sanjose S, Bosch X, Herrero R, Muñoz N,

Vaccarella S; International Agency for Research on Cancer Multicentric Cervical Cancer Study

Groups; International Agency for Research on Cancer Human Papillomavirus Prevalence

Surveys Study Group. Collaborators: Hammouda D, Eluf-Neto J, Aristizabal N, Tafur LA,

Rajkumar T, Bayo S, Chaouki N, El Gueddari B, Meijer CJ, Snijders PJ, van den Brule AJ,

Walboomers JM, Rolón PA, Caceres E, Santos C, Ngelangel C, Ascunce N, Castellsagué X,

Gili M, González LC, Izarzugaza I, Navarro C, Santamaria M, Chichareon S, Shah KV, Loria

D, Matos E, Ferreccio C, Luzoro A, Ojeda JM, Prado R, Dai M, Li N, Qiao YL, Wu RU, Molano

M, Posso H, Arslan A, Keita N, Lee DH, Shin HR, Dondog B, Pawlita M, Omigbodun A,

Thomas JO, Bardin A, Zatonski W, Sukvirach S, Tunsakul S, Meijer CJ, Snijders PJ, Smith K,

17

Anh PT, Hieu NT. Differences in the risk of cervical cancer and human papillomavirus infection

by education level. Br J Cancer. 2009 Sep 1;101(5):865-70. Epub 2009 Aug 4. [IF – 4.846]

78. Thangarajan Rajkumar *, Vijayalakshmi Neelakantan, Sabitha Kesavan, Sundersingh

Shirley, Ganesharaja Selvaluxmy, Mayil Vahanan Bose, Lavanya Nambaru. A 7 gene

expression score predicts for radiation response in cancer cervix. BMC Cancer 2009, 9: 365.

doi:10.1186/1471-2407-9-365. [IF – 3.08]

79. N Sudakar, Nirmala KN, Rajalekshmy KR, Rajkumar T. Diversity of T-cell receptor

rearrangements in South Indian patients with common ALL. Iranian J Immunology 2009, 6(3):

141-6.

80. Kanchan Murhekar, J Anuratha, Urmila Majhi, Thangarajan Rajkumar*. Expression of

human chorionic gonadotropin-β in gastric carcinoma: A retrospective immunohistochemical

study. Ind J Medical & Paediatric Oncology 2009, 30(3):99-102.

81. Neelakantan Vijayalakshmi, Babu Jully, Kesavan Sabitha, Thangarajan Rajkumar.

Computational prediction of Intrinsic disorder of EWS-FLI fusion protein. Bioinformatics Trend

2009, 4:53-61.

82. Ana Peixoto, Catarina Santos, Manuela Pinheiro, Pedro Pinto, Maria José Soares,

Patrícia Rocha, Leonor Gusmão, António Amorim, Annemarie van der Hout, Anne-Marie

Gerdes, Mads Thomassen, Torben Kruse, Dorthe Cruger, Lone Sunde, Yves-Jean Bignon,

Nancy Uhrhammer, Lucie Cornil, Etienne Rouleau, Rosette Lidereau, Koulis Yannoukakos,

Drakoulis Yannoukakos, Maroulio Pertesi, Steven Narod, Robert Royer, Maurício M. Costa,

Conxi Lazaro, Lidia Feliubadaló, Begoña Graña, Ignacio Blanco, Miguel de la Hoya, Trinidad

Caldés, Philippe Maillet, Gaelle Benais-Pont, Bruno Pardo, Eitan Friedman, Eladio Velasco,

Mercedes Durán, Maria-Dolores Miramar, Ana R. Valle, Ana Vega, Ana Blanco, Orland Diez,

Teresa Ramon, Carmen Alonso, Montserrat Baiget, Judith Balmaña, William Foulkes, Marc

Tischkowitz, Rachel Kyle, Nelly Sabbaghian, Patricia Ashton-Prolla, Ingrid P. Ewald,

Thangarajan Rajkumar, Luisa M. Vieira, Giuseppe Giannini, Alberto Gulino, Maria I. Achatz,

Dirce M. Carraro, Brigitte Bressac, Audrey Remenieras, Cindy Benson, Maureen Chung, Erik

Teugels, Manuel R. Teixeira. International distribution and age estimation of the Portuguese

BRCA2 c.156_157insAlu founder mutation. Breast Cancer Research and Treatment 2010,

July 22, Epub ahead of print. PMID: 20652400.

83. Rajkumar T. Personalized Medicine – FAQ’s. Ind J Med Paed Oncol 2010;31:72-74.

84. Mani Samson , Shirley Sunder Singh, Ranganathan Rama, Veluswami Sridevi,

Thangarajan Rajkumar. XPD Lys751Gln increases the risk of breast cancer in south Indian

women. Oncology Letters 2010, 2: 155-159.

85. Thangarajan Rajkumar *, Neelakantan Vijayalakshmi, Gopisetty Gopal, Kesavan Sabitha,

Shirley Sundersingh, Uthandaraman Mahalinga Raja, Ayloor Seshadri Ramakrishnan .

18

Identification and validation of genes involved in gastric tumourigenesis. Cancer Cell

International 2010;10:45.

86. Thangarajan Rajkumar *, Kesavan Sabitha, Neelakantan Vijayalakshmi, Sundersingh

Shirley, Mayil Vahanan Bose, Gopisetty Gopal, Ganesharaja Selvaluxmy. Identification and

validation of genes involved in cervical tumourigenesis. BMC Cancer 2011, 11:80.

PUBLIC EDUCATION ARTICLES

1. Rajkumar T*. Pugai namakku pagai. Article on ill effects of Tobacco in Tamil. Dhinakaran.

2. Rajkumar T*. Environment and Cancer. Hindu , 12-9-99.

3. Rajkumar T*. Hereditary cancers – FAQ. Hindu, 28-10-2001

4. Rajkumar T*. Cancer in the next decade. Reach, 2003.

EDITOR OF BOOKS

1. Postgraduate Oncology Update – Edited by Dr.V.Shanta and Dr.T.Rajkumar. Published by

IJCP Group of Publications, New Delhi, India. 2004.

19

NOVEL GENE MUTATIONS/SEQUENCES IDENTIFIED AND SUBMITTED TO GENE BANK

1: FJ940753

Links

Homo sapiens MLH1 (MLH1) gene, exon 14 and partial cds

gi|237930357|gb|FJ940753.1|[237930357]

2: FJ940752

Links

Homo sapiens BRCA1 (BRCA1) gene, exon 18 and partial cds

gi|237930355|gb|FJ940752.1|[237930355]

3: EU487217

Links

Homo sapiens EWS/FLI fusion protein mRNA, complete cds

gi|169655957|gb|EU487217.1|[169655957]

4: DQ075362

Links

Homo sapiens p53 gene, exon 7 and partial cds

gi|70611297|gb|DQ075362.1|[70611297]

5: DQ075361

Links

Homo sapiens truncated breast and ovarian cancer susceptibility protein 1 (BRCA1) gene,

exon 16 and partial cds

gi|70611295|gb|DQ075361.1|[70611295]

6: AY706912

Links

Homo sapiens breast and ovarian cancer susceptibility protein 1 (BRCA1) gene, exon 14 and

partial cds

gi|52001523|gb|AY706912.1|[52001523]

7: AY706911

Links

Homo sapiens breast and ovarian cancer susceptibility protein 1 (BRCA1) gene, exon 11 and

partial cds

gi|52001521|gb|AY706911.1|[52001521]

8: AY706914

Links

Homo sapiens mismatch repair protein (MLH1) gene, exon 10 and partial cds

gi|52001527|gb|AY706914.1|[52001527]

20

9: AY706913

Links

Homo sapiens breast and ovarian cancer susceptibility protein 1 (BRCA1) gene, exon 17 and

partial cds

gi|52001525|gb|AY706913.1|[52001525]

10: AY458144

Links

Homo sapiens breast and ovarian cancer susceptibility protein (BRCA1) gene, exon 11

gi|38488995|gb|AY458144.1|[38488995]

11: AY150865

Links

Homo sapiens truncated breast and ovarian cancer susceptibility protein (BRCA1) gene, exon

12 and partial cds

gi|25140445|gb|AY150865.1|[25140445]

12: AY144588

Links

Homo sapiens truncated breast and ovarian cancer susceptibility protein (BRCA1) gene,

partial cds

gi|23266699|gb|AY144588.1|[23266699]

13: AY344477

Links

Homo sapiens mutant mismatch repair protein (MSH2) gene, exon 3 and partial cds

gi|33622357|gb|AY344477.1|[33622357]

14: AY344476

Links

Homo sapiens MLH1 gene, mutant splice junction for exon 16

gi|33622356|gb|AY344476.1|[33622356]

15: AY344475

Links

Homo sapiens mutant mismatch repair protein (MLH1) gene, exon 18 and partial cds

gi|33622354|gb|AY344475.1|[33622354]

16: AY344474

Links

Homo sapiens truncated mismatch repair protein (MLH1) gene, exon 18 and partial cds

gi|33622352|gb|AY344474.1|[33622352]

21

Details of Oncologic Experience

a) Professional / Practical Training:

A Special Trainee in the Dept. of Cancer Chemotherapy, Govt. Royapettah Hospital, from 16-7-

85 to 15-1-86, under Prof. V.Srinivasan.

A Post-Graduate in D.M. (Medical Oncology) from April 1986 - March 1988. On successful

completion of the course in March 1988, continued to work as a full-time faculty member in the

Department of Medical Oncology, Cancer Institute, Adyar, Madras, India.

1. During this period, participated in treating patients with leukaemia and lymphomas, with

intensive multidrug protocols (collaborative protocol with NCI., Paediatric branch).

2. Formulated a chemotherapeutic protocol for carcinoma of ovary, which is under trial.

3. Have done more than 25 intraperitoneal chemotherapy with Melphalan in the management

of carcinoma ovary and malignant ascites.

4. Participated actively in the formulation of protocols for small cell lung cancer, soft-tissue

sarcomas and high grade spindle cell sarcomas of bone (e.g. osteosarcoma). High grade

spindle cell sarcomas of the bone are treated with the view to limb conservation. The trial is

ongoing.

5. Participant of the team which did four autologous bone marrow rescue after high dose

Melphalan.

6. Was the Medical Oncologist in charge of the management of Adult solid tumours.

b. Research Experience:

1. Laboratory

A. Worked on two short-term projects during my MBBS course.

i). Nosocomial Infection in Government General Hospital, Madras.

ii). Carrier status for parasitic infestation and typhoid bacilli, in food handlers in the city hotels.

B. Worked in the ICRF Molecular Oncology Unit, Hammersmith Hospital for my Ph.D.between

October 1991and October 1994. The title of my thesis was "Analysis of the Expression and

Function of the c-erbB3 protein in human tumours and Exploitation of its Targeting potential

in Immunotherapy ".

RESEARCH PROGRAMS AND PROJECTS

Established a Molecular Oncology Laboratory at the Cancer Institute. Recognised as a Guide

for Ph.D. students by the M.G.R. Medical University, Anna University and Madras University.

Two of the students has completed their Ph.D. and has been awarded their Ph.D (Their thesis

were "Highly Commended"). Four students are currently registered for their Ph.D.

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PCR based detection of Minimal residual disease in Acute lymphoblastic leukemias.

This study was funded by the NCI, Bethesda, USA. - completed.

Study of type 1 tyrosine kinase growth factor receptors and their growth factors in

breast and cervical cancers has been completed. The receptors studied include EGFR, c-

erbB2 and the growth factors include Amphiregulin, Cripto, and Heregulin.

BCL-2 and p53 expression in cervical cancers - completed.

Biologic characterisation of T-ALL-Funding obtained from NCI, Bethesda, USA.-Completed

Cell cycle regulatory molecules in cervical cancer - funding obtained from Dept. of

Science and Technology, Govt. of India - Completed

HPV in cervical cancer - a case control study - completed a collaborative programme with

IARC, Lyon, France.

HPV in Oral Cancer-Funded by IARC, Lyon, France-Completed

Identification of genes involved in radio-responsiveness in cervical cancer using

differential display.-Funding obtained from DAE-Completed.

Identification of genes involved in drug resistance in osteosarcomas using differential

display and microarray

Establishing a Population based Hereditary Cancer Registry covering Madras

Metropolitan Area – funded by WHO between Jan 2002 to Dec 2003; thereafter by Cancer

Institute (WIA)

Mutation analysis for hereditary breast cancers and hereditary colo-rectal cancers and

their prognostic significance - Funded by Dept. of Biotechnology, Govt. of India – Now by

Cancer Institute (WIA).

Development and clinical evaluation of dendritic cell vaccine for HPV related cervix

cancer - Funded by Dept. of Biotechnology, Govt. of India

Genetic polymorphisms and breast cancer – Funded by Chennai Willingdon Corporate

Foundation

Minimal Residual Disease detection in cervical cancer – Indo-German collaborative

project – ICMR funded.

Gene expression studies in cervical, breast and gastric cancers - DST

Development of structure based drugs against EWS:FLI fusion protein seen in Ewing’s

sarcoma. - DST

CLINICAL PROGRAMS

Running the country's first comprehensive Hereditary cancer clinic at the Institute.

Evaluation of the Dendritic vaccine for the treatment of cervical cancer - DBT funded

study.

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MEMBER

Member, International Collaboration of Epidemiological Studies of Cervical Cancer. (4

major publications have been published by the group).

Programme Advisory Committee, Dept. of Science and Technology since 2004.

Member, Technical Resource Group on Cancer, Ministry of Health and Family Welfare,

Govt. of India.

Member, Board of Research Studies, TN Dr.M.G.R Medical University – 2010 - 2012

Member, Screening Committee for projects on RNAi technology for its application in

agriculture and medicine, Dept. of Biotechnology, Govt. of India.

Task Force on Multi centre National programme on cervical cancer, Dept. of

Biotechnology, Govt. of India.

Member, Thematic Review Committee for Health Informatics, CDAC, Dept. of Information

and Technology, Govt. of India.

Member, Subject Expert Committee on Life Sciences of the FIST Program, Dept. of

Science and Technology, Govt. of India.

DBT Nominee for Institutional Bio-Safety Committee of CMC, Vellore.

Member, Scientific Advisory committee of Vision Research Foundation, Sankara

Nethralaya, Chennai.

Member, Ethical committee of YRG AIDS Research Foundation.

Member, Editorial Board, Hereditary Cancer in Clinical Practice.

Member, Editorial Board, Indian Journal of Cancer

REVIEWER

PROJECTS

Dept. of Science and Technology, Govt. of India

Dept. of Biotechnology, Govt. of India

Indian Council of Medical Research, Govt. of India

Welcome Trust, UK

European Commission

JOURNALS

British Journal of Cancer

Asia Pacific Journal of Cancer Prevention

Indian Journal of Biochemistry and Biophysics

Indian Journal of Medical and Paediatric Oncology

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FELLOWSHIP and MEMBERSHIP

Fellow of the National Academy of Medical Sciences (FAMS)

Indian Society of Oncology

Indian Association of Cancer Research

Indian Society of Human Genetics

Indian Society of Medical and Paediatric Oncology

Asia Pacific Organisation for Cancer Prevention

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