Page 1 of 16

Curriculum vitae, 2017

Hesham El-Seedi, Professor

1. Personal information

1.1 Name Hesham El-Seedi

1.2 Current Home address Franzengatan. 11215 Stockholm, Sweden

1.3 Telephone +46-700434343

1.4 Nationality Swedish

1.5 E-mail hesham.el-seedi@fkog.uu.se; hesham@kth.se

1.6 Gender Male

1.7 Affilation Department of Pharmacognosy, Uppsala Biomedical Center, Uppsala

University, Sweden.

2. Awards, Scientific

Achievements

2015, AWARD from STEFELSEN Foundation/Pharmacognosy:

For many years of Scientific Contributions to Pharmacognosy

Research and thereby increasing the knowledge about bioactive

Natural Products and building contributions with Developing

Countries. Nordic Natural Products Conference, Visby, Sweden

2015.

AWARD certificate and medal from University of Malakand,

27th

National and 15th International Chemistry Conference, 2016,

Pakistan.

Certificate of Appreciation for Invited Oral Presentation in the

Annual Colloquium on Drug Development from Natural Products

September 2015, Center for Natural Product Research and Drug

Discovery, UM, Malaysia.

Certificate of Appreciation for Invited Oral Presentation in the

Annual Colloquium on Drug Development from Natural Products

September 2014, Department of Pharmacy, Faculty of Medicine,

University of Malaya, Malaysia.

Published a paper in Lancet, Current Impact Factor 47.013, it

Page 2 of 16

was honored as the top article published in the department of

Pharmacognosy, Uppsala, Sweden. Published paper in J. Natural

Products as a Single author. ChemBioChem, Cover Picture.

AWARD certificate from Prof. Atta-ur-Rahman, UNESCO Science

Laureate for having participate as a SPEAKER in the 14th Asian

conference on Medicinal plants 2013, Karachi, Pakistan.

AWARD certificate and medal for having participate as

KEYNOTE SPEAKER in the 5th

conference on Research and

Standrization, Banda Aceh, November 2015.

Fellow of: Japanese Society of Promotion of Science (JSPS),

Swedish Institute (SI) and Wenner Green (WG).

Last but not least: 1st Award in B.Sc. - Chemistry (Excellent 4

years-Hon’s), El-Menoufia University, Egypt – and in accordance

the offer of permanent position for life with accredited leave for so

many years (scientific mission – child care –sabbatical - work or

study leave …etc).

3. Degrees, Assessments

and Evaluations

3.1 Academic degrees

Ph.D. - Organic Chemistry, Channel program with Kemisk Institute,

Aarhus University, Denmark / El-Menoufia University under

supervision of Prof. Kurt Torssell (Danish Side) (4 publications in

peer-reviewed International Journals) in co-operation with Prof. S.

El-Kousy (Egyptian Side), El-Menoufia University, (1 publication in

local Journal). The scientific mission was supported by Egyptian

Government based on my position.

M.Sc. - Organic Chemistry, Department of Chemistry, Faculty of

Science, El-Menoufia University, Egypt.

B.Sc. - Chemistry (Excellent with Hon’s) Department of Chemistry,

Faculty of Science, El-Menoufia University, Egypt.

Recommendation letters

3.2 Previous expert

assessments

Recommendation letters from Professors in Denmark, Sweden,

Germany, Austria, Japan and Egypt can be sent upon request.

Professor of Organic Chemistry, working between Department of

Pharmacognosy, Uppsala Biomedical Center, Uppsala University,

Sweden, University of Malaya, Malaysia, Chemical Ecology Group,

KTH, Stockholm, Sweden, El-Menoufia University, Egypt since

2007- till now.

Assistant Professor, working between Lab. of Pharmacognosy and

Phytochemistry, Dept. of Pharmacy, Geneva University,

Switzerland, under direction of Prof. Kurt Hostettman, Department

Page 3 of 16

of Pharmacognosy, Uppsala Biomedical Center, Sweden and

Menoufia University, Egypt 2003-2006.

Fellow of the prestigious Japanese Society of Promotion of Science

as Visiting Assistant Professor, Department of Chemistry, Faculty of

Science and Technology, Keio University, Japan, under direction of

Prof. Shosuke Yamamura and Prof. Shigeru Nishiyama 2001-2003.

Established important & unique contact with Bedouins in South and

North Sinai for herbal medicine (information of medical uses,

locations and collection) since 1998 till now.

3. Own research profile Isolation, structure elucidation and synthesis of biologically active

compounds from medicinal plants, marine and bee products with

emphasis on anti-inflammatory, anticancer, insecticidal and anti-

microbial.

4. Selected Funding

5. Leadership

6. Keynote Speaker,

Speaker and

chairmanship

7. Membership of

2016, Swedish Research Links grants for the 2017-2019 years

[2016-05908] with Prof. Ulf Göransson, Uppsala University,

Sweden. Isolation, structure elucidation and synthesis of cytotoxic

compound(s) from bee venom as anticancer lead in hepatocellular

carcinoma model

2016, Swedish Research Links grants for the 2017-2019 years

[2016-05885] with Dr. Sabrina Büttner, Stockholm University Bee

products to counteract age-associated cellular decay,

Grant in Aid Scientific Research [2007-6738] awarded to H. El-

Seedi, Anna-Karin Karlson and U. Gӧransson under the auspices of

the Swedish International Development Agency – Middle East and

North Africa [SIDA - MENA] 2007-2010.

Grant from Swedish Research Links (Sweden), Grant no. 348-2006-

6731 Chief investigator: H. El-Seedi and U. Göransson, 2006.

Grant from International Foundation for Science (IFS), Grant

F/3334-1. Chief investigator: H. El-Seedi. Holder of many

International Funds from: Swedish Institute (several times), Wenner-

Gren Foundation (three times) and Japan Society for Promotion of

Science (JSPS).

Member of the organizing committee for the Global Pharmacy

Course of Uppsala, and co-coordinator for two courses on 2006 and

2008.

Poster, oral presentation, workshops, invited speaker and head of

session in more than 30 conferences in Japan, Turkey, Sweden,

Germany, Denmark, England, China, Pakistan, Netherlands,

Norway, France, Finland, USA, Austria, United Arab Emirates,

Qatar, Egypt, Indonesia, Hong Kong and Malaysia.

Page 4 of 16

academies

8. Review/referee

assignments

9. Editorial/advisory

assignment

10. Assignment as

internal -external

examiner/opponent

11. Pedagogical

Achievements

Member of “The Chemical Society of Japan”, Japan.

Member of “Swedish Academy of Pharmaceutical Sciences”,

Sweden.

Member of “Phytochemical Society of Europe (PSE)”, The

Netherlands.

Member of Alumina Japanese Society of Promotion of Science

JSPS.

Referee for the following international scientific journals: Medicinal

Chemistry Research, Molecules, Journal of Natural Products,

Phytochemistry Letters, Journal of Agriculture and Food Chemistry,

Phytochemistry, Natural Products Research, African Journal of

Pharmacy and Pharmacology, Current Traditional Medicine and

Current Medicinal Chemistry.

The Icelandic Research Council, EU financing for cooperation with

African partners, The French National Research Agency and the

European commission.

Editing book “Natural products in clinical trials” with Prof. Atta-ur-

Rahman.

1st Opponent University of Karachi 2011- till now

PhD Thesis Examinerof Malaya University 2014 - till now

Member of the evaluation board and appointed at dissertations by

post-graduate students at Uppsala University and KTH, Sweden, El-

Menoufia University. 2004- till now

Teaching courses in Organic Chemistry / Natural Products /

Chromatography / Organic Synthesis / Special Topics / Spectroscopy

NMR course for PhD students at Uppsala University, Summer of in

co-operation with 2014. PRACTICAL BIOMOLECULAR NMR

SPECTROSCOPY. Department of Medicinal Chemistry, Uppsala

University: 9th

June-18th

June 2014, Dr. Johan Rosengren School of

Biomedical Sciences, University of Queensland and Prof. Hesham El

Seedi.

Principal supervisor of >30 diploma work, Principal

supervisor/examiner of >40 Master students, at undergraduate level.

Part-time supervisor of >25 foreign research students, PhD students,

guest scientists, and visitors in Keio University, Japan, El-Menoufia

University, Uppsala University, KTH, Stockholm and University of

Malaya, Malaysia and International Islamic University Malaysia,

Malaysia.

Guiding and Cooperation with several Post doctors and Professors in

several high level rank universities.

– 12. Conferences

– Conference of Organic Chemistry, Odensa University, Odensa, Denmark, June 1992 with a

Page 5 of 16

poster. Cycloaddition with alkoxynitrile oxides, R-O-C-N=O.

– Conference of Natural Products, Copenhagen, Denmark, January 1993 with an oral

presentation. Triterpenes, lichexanthone and an acetylenic acid from Minquartia guianensis.

– Conference of Organic Chemistry, Odensa University, Odensa, Denmark, June 1993 with a

poster. Cadinane sesquiterpenes from Siparuna macrotepala.

– Conference of Organic Chemistry, Kiel University, Kiel, Germany, August 1993 with an oral

presentation. Lipids and lignans from Haplophllum tuberculatum.

– Symposium on recent developments in NMR spectroscopy, Stockholm, Sweden, May 1996

with a poster. New isoflavones from Ceiba pentandra.

– International Conference on Plants for Food and Medicine, London, England, July 1996 with

an oral presentation. Chemistry of Bioflavonoids.

– Scandinavian Pharmacognosy Meeting, Pharmacognosy Dept., Uppsala, Sweden, August

1996, open discussions. New Sesquiterpenes from Siparuna macrotepala.

Symposium on recent developments in NMR Spectroscopy, Astra, Sweden, October 1996

with an oral presentation. Novel unexpected Cyclopeptide alkaloids from Heisteria nitida.

– International Conference: The Chemistry of Natural compounds (SCNC), Eskisehir, Turkey,

October 1996 with an oral presentation. Coumarins, benzoic acids and terpenoids from

Palicourea demissa.

– Swedish Pharmaceutical Congress (Lakemedlskongressen), Stockholm, Sweden, November

1996 with a poster. Triterpenes and flavanol glycosides from Aerva javanica.

– International Conference: Communication of Plants with Environment, Leiden, The

Netherlands, April 1997 with a poster and an oral presentation. Alkaloids from Haplophyllum

tuberculatum.

– Nordic Meeting: The future of Pharmacognosy, Pharmacognosy Dept., Helsinki, Finland,

June 1997 with a poster. Triterpenes from Gustavia longifoli.

– International Conference: Bioassay methods in Natural products, Uppsala, Sweden,

September 1997 with a poster. New Eudesmane derivatives from Laggera crispata.

– International Conference: Quality Assurance and Safety and Efficacy, Cairo, Egypt, March

1998 with two posters. Chemical constituents of Picris radicata.

– Swedish Pharmaceutical Congress, Stockholm, Sweden, October 1998 with a poster. Two

phenolics from Cissus sicyoides.

– Symposium of Mass spectrometry, Uppsala, Sweden, June 1999 with an oral presentation.

Ecologically active 2-Octanoylcyclohexane-1,3-dione from Philodendron guttiferum.

– International Conference: 2000 Years of Natural Products, Research, -Past-Present and

Page 6 of 16

Future-, Amsterdam, The Netherlands, July 1999 with an oral presentations. Flavenoids from

Laggera crispata.

– Ibn- Senia International Conference, Alexandria, Egypt, March 2000 with oral presentation.

Mescaline uses for 5700 years.

– International Conference: Diversity of Biosystems and Rational Production of Useful

Substances, Tokyo, Japan, March 2001 with an oral presentation: New Labdene diterpenes

from Eupatorium glutinosum.

– International Conference: The Seventh Max Tishler Memorial Symposium, Kitasato, Japan,

November 2001 with oral presentation. Reactivity of naphthol towards nucleophiles using

anodic oxidation.

– International Conference and Exhibition on the Modernization of Traditional Chinese

Medicine with poster, Chengdu, China, November 2002 with oral presentation. Constituents

of Hypericum larcifolium and their cyclooxygenase (COX) enzyme activities.

– International Symposium on Natural Product Chemistry, Karachi, Pakistan, January 2004

with oral presentations: Antimicrobial triterpenes from Poulsenia armata.

– ESMAP’s 11th

Conference & Exhibition, Cairo, Egypt, Sept 2004 with two oral presentations.

Chemosystematic value of novel unexpected cyclopeptide alkaloids from Heisteria nitida.

– 2005 Natural Products Chemistry meeting, Tjärnö, Sweden, June 2005 with oral presentation,

co-organizing committee. Novel Antimicrobial arylcoumarins from Asphodelus microcarpus.

– International Conference on drugs of natural origin: Materia Medica Linnaeus and Medicinal

Products, Uppsala, Sweden, September 2007 with poster. Essential oil analysis of

Micromeria nubigena and its antimicrobial activity.

– (NNPC) Natural Products Conference, Oslo, Norway, 2011 with oral presentation.

Anti-schistosomiasis triterpene glycoside from Asparagus stipularis.

– 5th International Conference on Drug Discovery & Therapy, Dubai, UAE. 18-21 February

2013. The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult

neural stem cells.

– (NNPC) Natural Products Conference, Turku, Finland, June 2013, 2013 with oral

presentation. The traditional medical uses and cytotoxic activities of sixty-one medicinal

plants.

– AWARD certificate from Prof. Atta-ur-Rahman, UNESCO Science Laureate for having

participate as a SPEAKER in the 14th

Asian conference on Medicinal plants 2013, Karachi,

Pakistan.

– International Conference on Natural Products, Faisalabad, Pakistan. 18-21 February 2014.

Invited speaker. A cactus derived toxin-like cystine knot peptide with selective antimicrobial

activity.

Page 7 of 16

– Alexander von Humboldt Foundation meeting, Ismailia, Egypt, December 2014, invited

speaker. Antibacterial effect of the red sea soft coral Sarcophytontroc heliophorum.

– Japanese Society Meeting, Cairo, Egypt. February 2015, Invited speaker. The role of

Secondary metabolism is still largely unclear!

– INBIOSIS workshop series 2015: Application of mass spectrometry in microbial

metabolomics analysis, Malaysia 28th

– 30th April 2015.

– NNPC Conference, Gotland, Sweden June, 2015 with two posters and presentation titled:

Isolation, structure elucidation and synthesis of bioactive peptides from bee products and the

traditional medical uses and cytotoxic activities of sixty-one Egyptian plants: Discovery of an

active cardiac glycoside from Urginea maritime and Adenium obesum. AWARD

– Certificate of Appreciation for Invited Oral Presentation in the Annual Colloquium on

Drug Development from Natural Products September 2015, Center for Natural Product

Research and Drug Discovery, UM, Malaysia.

– The Inaugural Symposium of the Phytochemical Society of Asia September, 2015 in

Tokushima, Japan 2015 with Oral Presentation titled: The role of secondary metabolism is

still largely unclear, Un-expecting results!

– Conference “the 26th

National and 14th

International Chemistry Conference” in the

Department of Chemistry, The Islamic University of Bahawalpur, Pakistan, October 2015,

invited Plenary Lecture titled: Secondary metabolites from natural sources: chemical and

pharmacological characterization of un-expecting results.

– AWARD certificate for having participate as KEYNOTE SPEAKER in the 5th conference

on Research and Standardization 2015, Banda Aceh, November 2015.

– Leiden conference, The Netherlands April 2016 with oral presentation: Plants mentioned in

Holy Qur'ân and Ahadith: their medicinal importance in contemporary times.

- The Fifth International Conference for Young Scientists in Basic and Applied Sciences"

Recent Approaches in Basic and Applied Sciences’’ Faculty of Science – Assiut University,

Assiut – Egypt, Oct 29th

– Nov 1st

2016, Invited Speaker. The role of secondary

metabolism is still largely unclear".

- Copenhagen Conference, Joint Natural Products Chemistry, July 2016 with oral

presentation." Identification of bioactive peptides from enzymatic hydrolysis of royal

jelly" and " Isolation, structure elucidation and synthesis of bioactive peptides from bee

products".

- The Fifth International Conference for Young Scientists in Basic and Applied Sciences"

Recent Approaches in Basic and Applied Sciences’’ Faculty of Science – Assiut University,

Assiut – Egypt, Oct 29th – Nov 1st, 2016, Invited Speaker. ." Lessons for nature: Bioactive

compound with unforeseen results".

- Future University conference, Cairo, Egypt, January 2017 with oral presentation." Drug

Page 8 of 16

discovery from natural products: An endless frontier".

- JSPS Alumni meeting in Cairo March 2017 with presentation Invited keynote presentation

March 15 – 16, 2017 " Lesson for nature: The role of secondary metabolism is still

largely unclear".

- Invited for presentation at School of Chemical Sciences, Universiti Sains Malaysia, Penang,

Malaysia, March 20, 2017. Lessons from nature: Bioactive ingredients; the unraveled

bio-resources!

13. List of Publication

Peer-reviewed articles

1. M.A. Farag, M.I. Fekry, M.A. Al-Hammady, M.N. Khalil, H.R. El-Seedi, A. Meyer, A. Porzel,

H. Westphal and L.A.Wessjohann. Cytotoxic Effects of Sarcophyton sp. Soft Corals. Is There a

Correlation to Their NMR Fingerprints? Marine Drugs 2017, 15, 211; doi:10.3390/md1507021.

2. Hesham R. El-Seedi, Muhammad Azeem, Nasr S., Khalil

Anna-Karin Borg-Karlson et al.

(2017): Essential oils of aromatic Egyptian plants repel nymphs of the tick Ixodes ricinus (Acari:

Ixodidae). Exp Appl Acarol, DOI 10.1007/s10493-017-0165-3.

3. M. Zahran, M. El-Kemary, S. Khalifa and H. R. El-Seedi (2017): Spectral studies of silver

nanoparticles biosynthesised by Origanum majorana: Green Process Synth 2017; Synth 2017

DOI: https://doi.org/10.1515/gps-2016-0183.

4. M. A. Farag, S. E. Ali, R. H. Hodaya, H. R. El-Seedi, H. N. Sultani, A. Laub, T. F. Eissa, F. O.

F. Abou-Zaid and L. A. Wessjohann (2017): Phytochemical Profiles and Antimicrobial Activities

of Allium cepa Red cv. and A. sativum Subjected to Different Drying Methods (2017): A

Comparative MS-Based Metabolomics. Molecules 2017, 22, 761; doi:10.3390. 22050761.

5. Larik, F.A., Saeed, A., Muqadar, U., El-Seedi, H., Faisal, M., Channar, P.A. and Mehfooz, H.

(2017): The Role of Lawesson's Reagent in the Total Synthesis of Macrocyclic Natural Products,

Phosphorus, Sulfur, and Silicon and the Related Elements, Available online.

http://dx.doi.org/10.1080/10426507.2016.125926.

6. El-Seedi, H.R., Khalifa S, Abd El-Wahed, A., Ali, H., Göransson, U., Verpoorte, R. et al.

(2017): Chemistry and biological activity of macrocyclopeptide alkaloids. Journal of Natural

Products. Accepted with minor revision.

7. A. Saeed, F. A. Larik, B. Lal, M. Faisal, H. El-Seedi & Pervaiz Ali (2017): Channar Recent

resurgence toward the oxidation of heteroatoms using dimethyldioxirane as an exquisite oxidant

Synthetic Communications ISSN: 0039-7911 (Print) 1532-2432 (Online) Journal homepage:

http://www.tandfonline.com/loi/lsyc20.

Page 9 of 16

8. Saeed, A., Larik, F.A., El-Seedi, H., Faisal, M., Mehfooz, H., Channar, P.A. (2017): Synthetic

approaches towards the multi target drug spironolactone and its potent analogues, Steroids, 118,

76-92.

9. Larik, F.A., Saeed, A., Muqadar, U., El-Seedi, H., Faisal, M., Channar, P.A. and Mehfooz, H.

(2017): Applications of Lawesson’s reagent in the synthesis of naturally occurring steroids and

terpenoids, Journal of Asian Natural Products Research, Available online.

10. A. Saeed, F. A. Larik, B. Lal, M. Faisal, H. El-Seedi, and Pervaiz A. Channar (2017): Recent

Resurgence Towards the Oxidation of Heteroatoms Using Dimethyldioxirane as an Exquisite

Oxidant, Synthetic Communications, Available online.

11. Saeed, A., Faisal, M., Larik, F. A., El-Seedi, H., Mehfooz, H., & Channar, P. A. (2017).

Advances in transition-metal-catalyzed synthesis of 3-substituted isocoumarins. Journal of

Organometallic Chemistry. In press.

12. El-Kemary, M., Ibrahim, I., A-Ajmi, M. F., Khalifa, S. M. A., Alanazi, A. D., El-Seedi, H. R.

2016. Calendula officinalis-mediated biosynthesis of Silver Nanoparticles and their

Electrochemical and Optical Characterization. Int. J. Electrochem. Sci.11, 10795-805.

13. M. S. Moustafa, S. M. Al-Mousawi, H. R. El-Seedi, and M. H. Elnagdi (2016): Chemistry of

Heterocyclic Five and Six Membered Enamino Nitriles and Enamino Esters Mini-Reviews in

Medicinal Chemistry. In press.

14. H. R. El-Seedi, Shaden A. M. Khalifa, Nermeen Yosri, Bassem Y. Sheikh, Thomas Efferth,

Mohamed F. AlAjmi, Rob Verpoorte (2017): Plants mentioned in the Holy Qur'ân and Ahadith:

their medicinal importance in contemporary times. Journal of Ethnopharmacology. Accepted

with major revision.

15. A. Saeed; R. Lyrik; P. Ali; C. Ali; H. El-Seedi (2017). The pivotal role of Chirality in the

classical and recent synthesis of (S)-Clopidogrel. Chirality. In press.

16. H. R. El-Seedi, M. Azeem, N. S. Khalil, H. H. Sakr, S. A.M. Khalifa, K. Awang, A. Saeed., M.

F. AlAjmi, K. Pålsson , A.-K. Borg-Karlson (2017): Essential oils of aromatic Egyptian plants

repel nymphs of the tick Ixodes ricinus (Acari: Ixodidae). Experimental and Applied Acarology.

In press.

17. Thulin, M., Moore, A., El-Seedi, H.R., Larsson, A., Christin, P.-A., Erika Edwards, J. (2016):

Phylogeny and generic delimitation in Molluginaceae, new pigment data in Caryophyllales, and

the new family Corbichoniaceae. Taxon, 65(4), 775-793.

18. Salama S.M., Gwaram N.S., AlRashdi A.S., Khalifa S.A.M., Abdulla M.A., Ali H.M., El-Seedi,

H.R. (2016): A Zinc morpholine complex prevents HCl/ethanol-induced gastric ulcers in a rat

model. Scientific Reports 6, 29646-29660.

Page 10 of 16

19. Shwter, A.N., Abdullah, N.A., Alshawsh, M.A., El-Seedi, H.R., Al-Henhena, N.A., Khalifa,

S.A. and Abdulla, M.A., (2016). Chemopreventive effect of Phaleria macrocarpa on Colorectal

cancer Aberrant Crypt Foci In vivo. Journal of Ethnopharmacology 193, 195-206.

20. A. A. Ahmed, Noordin MI, SAM Khalifa, R. Zaki, A S Sulaiman, A. Abdellah and H R El-

Seedi (2016): A Challenge Facing the Malaysian Pharmaceutical Sector: Quality and

Affordability of the National Medications. Research and Reviews: Journal of Pharmacy and

Pharmaceutical Sciences 5, 78-84.

21. El-Kemary, M., Zahran, M., Khalifa, S.A. and El-Seedi, H.R., (2016). Spectral characterisation

of the silver nanoparticles biosynthesised using Ambrosia maritima plant. Micro & Nano Letters

11, 311-314.

22. El-Seedi, H.R., Gomaa, M., Salem, M.M. Hamza, Z., Mansour, H.M., El khateeb, A., Khalifa,

S.A.M. et al. (2016): Cytotoxic effects of the red sea soft coral Sarcophytontroc heliophorum,

Acta Pol. Pharm. Drug Res. 73, 1587-1592.

23. Gomaa, M., Soliman, K., Salem, M., Ayesh, A., Abd El-Wahed, A., Hamza, Z., Keshk, H.M.,

Khalifa, S.M., Mansour, H.M., Ali, H.B., El Seedi, H.R. (2016): Antibacterial effect of the Red

Sea Soft Coral Sarcophytontroc heliophorum. Natural Product Research 30, 729-734.

24. Boldbaatar, D., Gunasekera, S., El-Seedi, H.R., Göransson, U. (2015): Synthesis, structural

characterization, and bioactivity of the stable peptide RCB-1 from Ricinus communis. Journal of

Natural Products78, 2545-2551.

25. Zajmi, A., Hashim, N.M., Noordin, M., Khalifa, S.A., Ramli, F., Ali, H.M., El-Seedi, H.R.

(2015): Ultrastructural study on the antibacterial activity of Artonin E versus streptomycin

against Staphylococcus aureus strains. Plos One 10, e0128157.

26. Aboye, T., Stromstedt, A., Gunasekera, S., Bruhn, J.G., El-Seedi, H.R., Rosengren, J.,

Goransson, U. (2015): A cactus derived toxin-like cystine knot peptide with selective

antimicrobial activity. ChemBioChem, Cover Picture 16, 1013.

27. Al-Henhena, N., Khalifa., S.A,, Ying, R.P., Ismail, S, Hamadi, R., Shawter, A.N., Idris, A.M.,

Azizan, A., Al-Wajeeh, N.S, Abdulla, M.A., El-Seedi, H.R. (2015): Evaluation of

chemopreventive potential of Strobilanthes crispus against colon cancer formation in vitro and in

vivo. BMC complementary and alternative medicine 25, 419-431.

28. Al-Henhena, N., Abdulla M., Ying R., Hassandarvis P., Rouhollahi, E., Al-Wajeeh, N., Khalifa

S.A.M., El-Seedi, H.R. (2015): Chemopreventive effects of Strobilanthes crispus leaf extract on

azoxymethane-induced aberrant crypt foci in rat colon. Scientific Reports, Nature Publishing

Group, 5, 13312

29. Karimian, H., Fadaeinasab, M., Moghadamtousi, S.Z., Hajrezaei, M., Zahedifard, M., Razavi,

M., Safi, S.Z., Mohan, S., Khalifa, S.A, El-Seedi, H.R., Abdulla, M.A. (2015): The

chemopreventive effect of Tanacetum polycephalum against LA7-Induced breast cancer in rats

and the apoptotic effect of a cytotoxic sesquiterpene lactone in MCF7 cells: A bioassay-guided

approach. Cellular Physiology and Biochemistry 36, 988-1003.

30. Zahedifard, M., Faraj, F.L., Paydar, M., Looi, C.Y., Hasandarvish, P., Hajrezaie, M.,

Kamalidehghan, B., Majid, N.A., Khalifa, S.A., Ali, H.M., Abdulla, M.A., El-Seedi, H.R.

(2015): Synthesis of apoptotic new quinazolinone-based compound and identification of its

Page 11 of 16

underlying mitochondrial signalling pathway in breast cancer cells. Current Pharmaceutical

Design 21, 3417-3426.

31. Hajrezaie, M., Salehen, N., Karimian, H., Zahedifard, M., Shams, K., Al Batran, R., Majid,

N.A., Khalifa, S.A., Ali, H.M., El-Seedi, H.R., Abdulla M.A. (2015): Biochanin a

gastroprotective effects in ethanol-induced gastric mucosal ulceration in rats. PLoS One. 10,

0121529.

32. Khalifa, S.A.M., de Medina, P., Erlandsson, A., El Seedi, H.R., Silvente-Poirot, S., Poirot, M.

(2014): The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural

stem cells. Biochemical and Biophysical Research Communications 446, 681-686.

33. Al-Henhena, N., Yuen Ying, R.P., Ismail, S., Najm, W., Khalifa, S.A.M., El-Seedi, H.R.,

Abdulla, M.A. (2014): Chemopreventive efficacy of Andrographis paniculata on azoxymethane-

induced aberrant colon crypt foci in vivo. Plos One 9, e111118-e111129.

34. Boldootar, D., El-Seedi, H.R., Findakly, M., Jabri, S., Javzan, B., Choidash, B., Goransson, U.,

Hellman, B. (2014): Antigenotoxic and antioxidant effects of the Mongolian medicinal plant

Leptopyrum fumarioides (L): An in vitro study. Journal of Ethnopharmacology 155, 559-606.

35. Sakr, H.H., Roshdy, S.H., El- Seedi, H.R. (2013): Hyptis brevipes (Lamiaceae) extracts strongly

inhibit the growth and development of Spodoptera littoralis (Boisd.) Larvae (Lepidoptera:

Noctuidae). Journal of Applied Pharmaceutical Science 3, 083-088.

36. El-Seedi, H.R., Burman, R., Mansour, A., Turki, Z., Boulos, L., Gullbo J., Göransson, U. (2013):

The traditional medical uses and cytotoxic activities of sixty-one Egyptian plants: Discovery of

an active cardiac glycosides from Urginea maritima. Journal of Ethnopharmacology 145, 746-

757.

37. Demma, J., El-Seedi, H.R., Engidawork, E., Aboye, T.L., Göransson, U., Hellman, B. (2013):

An in vitro study on the DNA damaging effects of phytochemicals partially isolated from an

extract of Glinus lotoides. Phytotherapy Research 27, 507-514.

38. Gunasekera, S., Aboye, T.L., Madian, W.A., El-Seedi. H.R., Göransson U. (2013): Making ends

meet: microwave-accelerated synthesis of cyclic and disulfide rich proteins via in situ

thioesterification and native chemical ligation. International Journal of Peptide Research and

Therapeutics 19, 43-54.

39. Göransson U., Gunasekera, S., Strömstedt, A., Burman, R., Rosengren, K.J, El-Seedi, H.R.,

Malik, S.Z., Park, S., Yeshak, M. Y. (2012): Discovery and applications of circular cystine

knotted peptides. Journal of Peptide Science 18, S51-S52.

40. El-Seedi, H.R., El-Shabasy, R.M., Sakr, H., Zayed, M., El-Said, A.M.A., Helmy, K.M.H.,

Gaara, A.H.M., Turki, Z., Azeem, M., Ahmed, A.M., Boulos, L., Borg-Karlson, A.-K.,

Göransson, U. (2012): Anti-schistosomiasistriterpene glycoside from the Egyptian medicinal

plant Asparagus stipularis. Revista Brasileira de Farmacognosia 22, 314-318

Page 12 of 16

41. El-Seedi, H.R., Abd El-Wahed, A.A.A, Sakr, H., El-Ghorab, D.M.H., Eldeen, N.S., Madian,

W.E.B.H., Hamza, Z.K. and El-Torgoman, A.M. (2012): Antibacterial activity and analysis of

the essential oil from the aerial parts of Psoralea mutisii (Leguminoseae). Current Topics in

Phytochemistry 11, 27-33.

42. El-Seedi, H.R., Khalil, N.S., Azeem, M., Taher, E.A., Göransson, U., Pålsson, K., Borg-Karlson,

A.-K. (2012): Chemical composition and repellency of essential oils from four medicinal plants

against Ixodes ricinus (L.) nymphs (Acari: Ixodidae). Journal of Medical Entomology 49, 1067-

1075.

43. Svahn, S.K., Göransson, U., El-Seedi, H.R., Bohlin, L., Larsson, D.G. J., Olsen, B.,

Chryssanthou, E. (2012): Antimicrobial activity of filamentous fungi isolated from highly

antibiotic- contaminated river sediment. Infection Ecology & Epidemiology 2, 11591-11596.

44. Svahn, K.S., Goransson, U., Stromstedt, A., El-Seedi, H.R., Bohlin, L., Larsson, D. G.J., Olsen,

B., Chryssanthou E. (2012): The search for new antibiotic substances from filamentous fungi.

Planta Medica 78, 1162-1162.

45. El-Seedi, H.R., Zayed, M., Roshdy, S., Salem, M., Hawata, M., El-Essawy, F., El-Barbary, M.,

El-Kousy, S. (2010): Analysis of the essential oil from the aerial parts of Psoralea pubescence

(Miq.) Standl and its antibacterial activity. Medicinal Chemistry Research 19, 1036-1042.

46. Ibrahim, N.A., El-Seedi, H.R., Mohammed, M.M.D. (2009): Constituents and biological activity

of the chloroform extract and essential oil of Cupressus sempervirens. Chemistry of Natural

Compounds 45, 309-313.

47. El-Seedi, H.R., Khattab, A., Gaara, A.H.M., Mohamed, T.K., Hassan, N.A., El-Kattan, A.E.

(2008): Essential oil analysis of Micromeria nubigena HBK and its antimicrobial activity.

Journal of Essential Oil Research 20, 452-456.

48. Bruhn, J.G., El-Seedi, H.R., Stephanson, N., Beck, O., Shulgin, A.T. (2008): Ecstasy analogues

found in cacti. Journal of Psychoactive Drugs 40, 219.

49. El-Seedi, H.R. (2007): Antimicrobial arylcoumarins from Asphodelus microcarpus. Journal of

Natural Products70, 118-120.

50. El-Seedi, H.R. (2007): New long chained feruloyl ester from the bark of Cedrelinga

cateneoformis. Chemistry of Natural Compounds 43, 256-258.

51. Ibrahim, N.A., El-Seedi, H.R. and Mohammed, M.M.D. (2007): Phytochemical investigation

and hepatoprotective activity of Cupressus sempervirens L. leaves growing in Egypt. Natural

Product Research 21, 857-866.

52. Bucar, F., Roberts, M.F. and El-Seedi, H.R. (2007): Sterones and indole alkaloid from Ailanthus

altissima callus cultures. Chemistry of Natural Compounds 43, 234-236.

53. El-Seedi, H.R., Khattab, A., Gaara, A.H.M., Mohamed, T.K., Hassan, N.A. and El-Kattan, A.E.

(2008): Essential oil analysis of Micromeria nubigena H.B.K. and its antimicrobial activity.

Journal of Essential Oil Research 20, 452-456.

54. El-Seedi, H.R. (2006): Microbial activity and chemical composition of essential oil of

Eupatorium glutinosum (Asteraceae). Natural Products Communications 1, 655-659.

55. Sandberg, F., Perera-Ivarsson, P. and El-Seedi, H.R. (2005): Swedish collection of medicinal

plants from Cameroon. Journal of Ethnopharmacology 102, 336-343.

Page 13 of 16

56. El-Seedi, H.R., De Smet, P.A.G.M., Beck, O., Possnert, G. and Bruhn J.G. (2005): Prehistoric

peyote use: Alkaloid analysis and radiocarbon dating of archaeological specimens of Lophophora

from Texas. Journal of Ethnopharmacology 101, 238-242.

57. El-Seedi, H.R. (2005): Antimicrobial triterpenes from Poulsenia armata Miq. Standl. Natural

Products Research 19, 197-202.

58. Pathmasiri, W., El-Seedi, H.R., Han, X., Janson, J.-C., Huss, U. and Bohlin, L. (2005): Aryl

ketones from Acronychia pedunculata with Cyclooxygenase-2 inhibitory effects. Chemistry and

Biodiversity 2, 463-469.

59. El-Seedi, H.R., Larsson S. and Backlund A. (2005): Chemosystematic value of cyclopeptide

alkaloids from Heisteria nitida (Olacaceae). Biochemical Systematics and Ecology 33, 831-839.

60. El-Seedi, H.R. (2003): Sesquiterpenes and triterpenes from Sonchus oleraceus (Asteraceae).

ACGC Chemical Research Communications16, 14-18.

61. El-Seedi, H.R., Ringbom, T., Torssell, K.B.G. and Bohlin, L. (2003): Constituents of Hypericum

larcifoliumand their cyclooxygenase (COX) enzyme activities. Chemical and Pharmaceutical

Bulletin 51, 1439-1440.

62. El-Seedi, H.R., Yamamura, S. and Nishiyama, S. (2002): Reactivity of naphthol towards

nucleophiles using anodic oxidation. Tetrahedron 58, 7485-7489.

63. El-Seedi, H. and El-Khodry, A.E. (2002): Flavenoids from Laggera crispata. Afinidad 59, 205-

210.

64. Bruhn, J.G., De Smet, P.A.G.M., El-Seedi, H.R. and Beck, O. (2002): Mescaline uses for 5700

years. The Lancet 359, 1866-1867.

65. El-Seedi, H. R., Sata, N., Torssell, K.B.G. and Nishiyama, S. (2002): New Labdenediterpenes

from Eupatorium glutinosum. Journal of Natural Products 65, 728-729.

66. El-Seedi, H.R. and Nishiyama, S. (2002): Chemistry of Bioflavonoids Part I of III (review). I.

Journal of Pharmaceutical Education 36, 95-106.

67. El-Seedi, H.R., Yamamura, S. and Nishiyama, S. (2002): Anodic oxidation of 4-Methoxy-1-

naphthol. Tetrahedron Letters 43, 3301-3304.

68. El-Seedi, H.R. (2002): Bioactive constituents from Margicarpus spinnatus. ACGC Chemical

Research Communications 15, 6-10.

69. El-Seedi, H.R. and Nishiyama, S. (2002): Chemistry of bioflavonoids Part II of III (review). I.

Journal of Pharmaceutical Education 36, 124-129

70. El-Seedi, H.R., Ohara, T., Sata, N. and Nishiyama, S. (2002): Antimicrobial diterpenoids from

Eupatorium glutinosum (Asteraceae). Journal of Ethnopharmacology 81, 293-296.

71. El-Seedi, H.R., Bohlin, L., Ghia, F. and Torssell, K.B.G. (2001): Ecologically active 2-

Octanoylcyclohexane-1,3-dione from Philodendron guttiferum. Journal of Chemical Ecology 27,

517-521.

72. Ahmed, A.A., Adams, A.D., El-Seedi, H.R. and Mabry, T.J. (2000): Two phenolics from Cissus

sicyoides. Revista Latinoamericana de Quimica 28, 40-42.

73. El-Seedi, H.R. (2000): Chemical constituents of Picris radicata. Afinidad 57, 229-231.

74. El-Seedi, H.R., Zayed, M., Morono, F.G. and Torssell, K.B.G. (1999): Triterpenes from

Gustavia longifoli. Revista Latinoamericana de Quimica 27, 56-57.

75. El-Seedi, H.R., El-Moselhy, T.F., Sobaih, S.A., Abd El-Bary, H.A., El-Kousy, S.M. and Zeid,

I.F. (1999): Alkaloids from Haplophyllum tuberculatum. Revista Latinoamericana de Quimica

27, 22-25.

Page 14 of 16

76. El-Seedi, H.R. and Sobaih, S.A. (1999): Triterpenes and flavanol glycosides from Aerva

javanica. Revista Latinoamericana de Quimica 27, 17-21.

77. El-Seedi, H.R. (1999): Coumarins, benzoic acids and terpenoids from Palicourea demissa.

Revista Latinoamericana de Quimica27, 13-16.

78. El-Seedi, H.R., Gohil, S., Perera, P., Torssell, K.B.G. and Bohlin, L. (1999): Cyclopeptide

alkaloids from Heisteria nitida. Phytochemistry 52, 1739-1744.

79. El-Seedi, H.R. (1999): Sesquiterpenes from Siparuna macrotepala. Pak. J. Biol. Science 2, 251-

254.

80. Ahmed, A.A., El-Seedi, H.R., Mahmoud A.A., El-Douski, A.E., Zeid, I.F. and Bohlin, L.

(1998): Eudesmane derivatives from Laggera crispata and Pluchea carolonesis. Phytochemistry

49, 2421-2424.

81. Noreen, Y., El-Seedi, H., Perera, P. and Bohlin, L. (1998): Two new isoflavones from Ceiba

pentandra and their effect on cyclooxgenase-catalyzed prostaglandin biosynthesis. Journal of

Natural Products 16, 8-12.

82. El-Khrisy, E.A.M., Nassar, M.I., El-Kousy, S.M., El-Sakka, I. and El-Seedi, H.R. (1996): Lipids

and 13C NMR spectra of some lignans from Haplophllum tuberculatum. Bulletin of the National

Research Centre 21, 93-97.

83. Bach, K.K., El-Seedi, H.R., Jensen, H.M., Nielsen, H.B., Thomson, I.B. and Torssell, K.B.G.

(1994): 1,3-Dipolar cycloaddition of ethoxycarbonylnitrilebenzylimine, EtOOCC=NCH2C

6H

5

and synthesis of amino acid. Synthesis and reactions of ethyl 2-chloro-2-ethoxyacetate and 2-

chloro-2-ethoxyacetyl chloride. Tetrahedron 50, 7543-7556.

84. El-Seedi, H.R., Ghia, F. and Torssell, K.B.G. (1994): Cadinane sesquiterpenes from Siparuna

macrotepala. Phytochemistry 35, 1495-1497.

85. El-Seedi, H.R., Hazell, A.C. and Torssell, K.B.G. (1994): Triterpenes, lichexanthone and an

acetylenic acid from Minquartia guianensis. Phytochemistry 35, 1297-1299.

86. El-Seedi, H.R., Jensen, H.M., Kure, N., Thomson, I. and Torssell, K.B.G. (1993): Cycloaddition

with alkoxynitrile oxides, R-O-C-N=O, (Alkyl Cyanate N-Oxides). Acta Chemica Scandinavica

47, 1004-1011.

Review articles

87. El-Seedi, H.R., El-Said, A.M.A., Khalifa, S.A, Göransson, U., Bohlin, L., Borg-Karlson, A.-K.,

Verpoorte, R. (2012). Biosynthesis, natural sources, dietary intake, pharmacokinetic properties

and biological activities of hydroxycinnamic acids. Journal of Agricultural and Food Chemistry

60, 10877-10895.

88. El-Seedi, H.R., El-Barbary, M.A., El-Ghorab, D.M.H., Bohlin, L., Borg Karlson, A.-K.,

Göransson, U., Verpoorte, R. (2010). Recent insights into the biosynthesis and biological

activities of natural xanthones. Current Medicinal Chemistry 17, 854-901.

89. El-Seedi, H.R., El-Ghorab, D.M.H., El-Barbary, M.A., Zayed, M.F., Göransson, U., Larsson, S.,

Verpoorte, R. (2009). Naturally occurring xanthones; latest investigations: isolation, structure

elucidation and chemosystematic significance. Current Medicinal Chemistry 16, 2581-2626.

90. El-Seedi, Hesham R., Zahra, M.H., Göransson, U. and Verpoorte, R. (2007): Cyclopeptide

alkaloids. Phytochemistry Reviews 6, 143-165.

91. El-Seedi, H.R. and Nishiyama, S. (2002): Chemistry of Bioflavonoids Part III of III (review). I.

Journal of Pharmaceutical Education 36, 191-202.

92. Moustafa S. M, Saleh M. Al-Mousawi, H.R. El-Seedi and Mohamed Hilmy Elnagdi (2017):

Chemistry of Heterocyclic Five and Six Membered Enamino Nitriles and Enamino Esters.

Mini-Reviews in Medicinal Chemistry. In press.

Page 15 of 16

93. M.S. Moustafa, S.M. Al-Mousawi, H.R. El-Seedi and M.H. Elnagdi (2017): Tales of the

Unexpected in Synthesis of Polyfunctional Heteroaromatics. Current Organic Synthesis.

Accepted with minor revision.

Chapters in Books:

94. El-Seedi, H.R., Taher E.A., Sheikh B.A., Anjum, S., Khalifa, S.A.M. (2016): Significance of

hydroxycinnamic acids: Natural sources, possible biological activities, recommended daily

allowance. Studies in Natural Products Chemistry (Bioactive Natural Products). 2016

ELSEVIER SCIENCE PUBLISHERS – AMSTERDAM. In press.

95. Hesham R. El-Seedi, Aida A. Abd El-Wahed, Bassem Y. Sheikh, Shaden A. M. Khalifa, Aamer

Saeed, UfukKoca-Caliskan, Mohammad F. AlAjmi, Rob Verpoorte (2017). Bee venom

composition; unraveling the biodiversity and the potential biological activities. Studies in Natural

Products Chemistry (Bioactive Natural Products). 2017 ELSEVIER SCIENCE PUBLISHERS –

AMSTERDAM. Accepted.

On-going Publications:

96. El-Seedi, H.R., El-Shabasy, R.M., Khalifa, S., Aamer, S. and Borg-Karlson, A.-K. (2018): Green

chemical methods to control ticks. Arthropod-Plant Interaction. In preparation in final steps.

97. El-Seedi, H.R., Khalifa S., Aamer, S. and Verpoorte, R. (2018): Enhancing molluscidal natural

control strategy: Plants and plant-derived compounds.

98. El-Seedi, H.R., Said, A., Khalifa S. and Göransson, U. (2018): Isolation and chemical structural

identification of new cardiac glycoside from Adenium obesum with cytotxic activity.

99. Abd El Wahed, A., Gunasekera, S., El-Seedi, H.R. and Göransson, U. (2018): Isolation and

synthesis for secapin from bee venom (Apis mellifera L.) In preparation. 100. El-Seedi, H.R., R. Larsson, Bohlin, L. (2018): Zizyphol, a novel sesterterpene from

Alphitonia zizyphoides inhibiting PAF-induced exocytosis in vitro.

101. A El Wahed, S Gunasekera, HR El-Seedi and U Göransson (2018): Identification and

synthesis of bioactive royalisin derived from royal jelly. In preparation.

102. El-Seedi, H.R., El-Shabasy, R.M., Aamer, S., Farag, M., Saeed, A., Khalifa S et al. (2017):

Cyclooxygenase activity of aryl ketone from Acronychia pedunculata (L.) Rutaceae; will be

submitted to Planta Medica. In preparation.

103. Boldootar, D., Hellman, B., Goransson, U. and El-Seedi, H.R. (2018): Novel alkaloid from

the Mongolian medicinal plant: Leptopyrum fumarioides (L.) Rchb. In preparation.

104. Abd El-Wahed, A., Al-Ahmady, N., El-Enain, H. T., Burman, R., El-Seedi, H.R. and

Göransson, U. (2018): Isolation and structure elucidation of new cytotoxic polypeptide from bee

venom. In preparation.

105. Hesham R. El-Seedi, Nermeen Yosri, Shaden A. M. Khalifa, Mohamed F.

AlAjmi, Mohamed A. Farag, Aamer Saeed, Thomas Efferth, Rob Verpoorte (2018): Exploring

Cancer Therapeutics with Natural Products from Egyptian Flora. Journal of Ethnopharmacology.

In preparation.

Page 16 of 16

Books:

106. Series Editor: Prof. Atta-ur-Rahman FRS, Prof. Shazia Anjum and Prof. Hesham El-

Seedi. eBook series entitled: “Natural Products in Clinical Trials” (2017 -8): In press.

Bentham Science Publishers.

Submitted manuscripts:

107. F Larik; F Jabeen; M Erben; HR El-Seedi; P Channar (2017): Cyclization of acyl thiourea an

efficient route towards novel N-(4-phenyl-3-aroyl-2 (3H)-ylidene) substituted acetamides,

synthesis, and selective inhibition of AChE and BChE, drug profiling and Molecular docking

studies. Biochemical and Biophysical Research Communications: Submitted.

108. T. Efferth, M. Banerjee, M. S. Abu-Darwish, S. Abdelfatah, M. Böckers, D. Bhakta-Guha, V.

Bolzani, S. Daak, O. Demirezer, M. Dawood, M. Efferth, N. Mahmoud, H. R. El-Seedi et al.

Biopiracy versus One-World Medicine – From Colonial Relicts to Global Collaborative

Concepts. In process.

109. Salem, T.A.-R., Khalifa S and Zahra, M. and El-Seedi, H.R. (2017): Cytotoxic profile of

Alpinia zerumbet in human cancer cell lines and antioxidant activity. Submit to Natural products

Communications.

110. M Azeem, Z Iqbal, G Nordlander, H Nordenhem, R Mozuratis, HR El-Seedi, AK Borg-

Karlson (2017): Chemical composition and antifeedant activity of some aromatic plants

against pine weevil (Hylobius abietis). Submit to Journal of Applied Entomology.

111. PA Channar; FA Larik; S Kalsoom; MM Hasan; HR El-Seedi; MF Erben; Z Ashraf; M Ali

(2017): Synthesis of Aryl Pyrazole via Suzuki coupling reaction, in vitro mushroom tyrosinase

enzyme inhibition assay and in silico comparative molecular docking analysis with Kojic acid.

Submitted to: Bioorganic & Medicinal Chemistry Letters.

112. M Farag, D Rasheed; A Porzel, A Frolov, H R El Seedi, LA Wessjohann (2017):

Comparative analysis of Hibiscus sabdariffa (roselle) hot and cold extracts in respect to their

potential for the inhibition of alpha-glucosidase. Food Chemistry.

113. F. Larik; F. Jabeen; M. Erben; H. R El-Seed; P. Channar (2017): Cyclization of acyl thiourea

an efficient route towards novel N-(4-phenyl-3-aroyl-2 (3H)-ylidene) substituted acetamides,

synthesis, and selective inhibition of AChE and BChE, drug profiling and Molecular docking

studies. Biochemical and Biophysical Research Communications. Submitted.

114. PA Channar; A Saeed; F Larik; S Kalsoom; M Hasan; MF Erben; HR El-Seedi; MZ Ashraf;

M Ali (2017): Aryl pyrazoles are well recognized class of heterocyclic compounds found in

several commercially available drugs. Research on Chemical Intermediates. Submitted.