Nadder D. Sahar, Ph.D. 11919 W. Verona Ct; Milwaukee, WI 53227 414-810-6233 nadder@gmail.com

SUMMARY OF QUALIFICATIONS • Employed innovative problem-solving skills and initiative to independently expand techniques and knowledge

base towards mechanical design and biomedical research • Extensive education and experience in mechanical engineering, statistics, physiology, micro- and nano-scale

material testing, spectroscopy and micro-computed tomography • Seven years experience working with laboratory animals and animal/human tissues • Managed collaborative research efforts and mentored numerous students in research techniques and

experimental design

EDUCATION University of Michigan, Ann Arbor, MI

Ph.D. Biomedical Engineering February 2009 GPA: 3.91 / 4.00 Thesis Title: Investigating the Effects of Aging and Exercise on Bone Composition

and the Impact of Composition on Mechanical Integrity Honors: • Regenerative Sciences Training Grant R90-DK071506, 2006-2008 • Best Poster Presentation, Midwest Biomedical Engineering Conference, 2006

M.S.E. Biomedical Engineering May 2004 GPA: 3.97 / 4.00; Specialization in Biomechanics Research: Kinetic modeling of impact forces and moments at the knee during jump landings Honors: Department Fellowship, 2002-2003

Northwestern University, Evanston, IL B.S. Biomedical Engineering June 2000 GPA: 3.56 / 4.00; Specialization in Biomechanics Honors: • Best Biomedical Engineering Senior Design Project, 2000

• 1st Place, 2000 Engineering Design Competition • 2nd Place, 1999 Engineering Design Competition

EXPERIENCE University of Michigan, Ann Arbor, MI

Research Fellow 2009 • Developed new collaborations to pursue studies proposed in my Ph.D. thesis (topics involving

bone adaptation, composition and mechanics) • Mentored graduate students, guiding development of new hypotheses on bone adaptation

and associated experimental designs

Researcher (collaboration with University of California, Santa Barbara) 2007-2009 • Refined and validated a minimally invasive diagnostic instrument to measure

mechanical properties of bone through soft tissue • Developed strategies for commercialization of the instrument

Regenerative Sciences Training Program Fellow 2006-2008 • Trained with a multidisciplinary team of engineers, biologists and clinicians in an

NIH-sponsored program designed to speed clinical translation of biomedical research Strengthened knowledge of intellectual property, technology transfer and patents; clinical trials an• d FDA compliance; startup companies and funding sources

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Graduate Student Research Assistant 2003-2Conducted thesis research on the influence of exercis l

008 • e and aging on bone’s biochemica

properties and mechanical integrity • Trained and advised undergraduate and graduate students assisting with thesis-related projects • Developed new experimental techniques; refined and automated time-consuming analyses

UOP, LLC., Des Plaines, IL Design Engineer 2000-2002 • Independently designed reactors and internal components for petroleum refinement • Analyzed flow, pressure distribution, stress and thermal expansion • Devised novel designs for custom retrofitting of reactors • Supervised international crew of 20 members during installation of components

Marquette University, Milwaukee, WI Research Assistant 1999 • Designed and built a device for pressure distribution testing of knee implants at various flexion angles

ACTIVITIES • Built a passive-dynamic walking robot, Medical University of South Carolina 2010 • Trekked to Mt. Everest Base Camp in Nepal 2009 • Incorporated a nonprofit company to raise funds for leukemia research 2009 • Graduate Student Mentor, University of Michigan 2005-2008 • Graduate Vice President, Biomedical Engineering Society, University of Michigan 2003-2004 • Chicago Cares Volunteer and Project Leader 2000-2002 • Hobbies: ice hockey, photography, adventure travel

SKILLS • Wide-ranging laboratory experience, which includes mechanical testing, nanoindentation, laser scanning

confocal microscopy and micro-computed tomography • Extensive experience working with laboratory mice and tissues: handling, injections, dissection, sterile

techniques and histological sample preparation • SPSS and statistical techniques, including advanced regressions • Programming: Matlab, Labview, C, C++, Visual Basic, Fortran, Pascal • Drawing and image creation with AutoCAD, Microstation, Adobe Illustrator and Photoshop • Design and fabrication of devices for use in research

PEER-REVIEWED PUBLICATIONS Sahar, ND, K Golcuk, MS Ron, SR Obreiter, DH Kohn, “Exercise Improved Tissue Strength, Fatigue Resistance, and Mineral Composition of Pre-Existing Tissue in Murine Tibiae,” (in review)

Raghavan, M, ND Sahar, RH Wilson, M Mycek, N Pleshko, DH Kohn, MD Morris, “Quantitative Polarized Raman Spectroscopy in Highly Turbid Bone Tissue,” (in review)

Sahar, ND, K Golcuk, MD Morris, LA Winkel, DH Kohn, “Aging Decreased Mechanical Properties of Bone by Compromising Tissue Quality, not Quantity, in Murine Tibiae,” (in review)

Sahar, ND, M Raghavan, MD Morris, DH Kohn, “Compositional Changes of Bone Mineral and Matrix Have Correlations with Mechanical Properties that May Depend on Bone Age and Initial Composition,” (in review)

Xu, J, P Zhu, Z Gan, N Sahar, M Tecklenburg, M Morris, D Kohn, A Ramamoorthy, “Natural-Abundance 43Ca NMR and Raman Spectroscopy of Bone,” (in review)

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Ra Mycek, N Pleshko, DH Kohn, MD Morris, “Polarized RamanSp

Ra ructure of Ca iew)

, N Sahar, D Kohntific Instrumentatio

Zh d Matrix-SpeciStr 6: 71660F (2009) Ko nd Matrix Composition in the

Kohn, “PBio ings of SPIE 6853: 68530W 2008)

Ha n, F Garza-de-Leon, G Fantner, H Mkrtchyan, M Pontin, A Weaver, MB Brown, N Sahar, R Rossello, D Kohn, “The

ic Instrument II: Indentation Distance Increase,” Review of Scientific Instrumentation 79(6): 064303

ey, ND Sahar, DH Kohn, MD Morris, “Rapid Ramtron-Multiplying CCD (EMC

ching ser?” Biochim. Biophys. Acta 1758: 868-873

, “Local Mineral and Matrix Changes Associated with Bone Adaptation and Microdamage,” Proceedings of the Materials Research Society 898E: 1-11 (2006)

D, SI Hong, DH Kohn, “Micro- and Nano-Structural Analyses of Damage in Bone,” Micron 36: 617-629

hanical (2005)

ghavana, M, ND Sahar, RH Wilson, M ectroscopy of Bone Tissue: Watch the Scattering,” (in review)

mamoorthy, A, J Xu, P Zhu, Z Gan, N Sahar, M Morris, M Tecklenburg, D Kohn, “Probing the St revlcium Sites in Bone Mineral by Natural-Abundance 43Ca Solid-State NMR Spectroscopy,” (in

Randall, C, P Mathews, E Yurtsev , P Hansma, “The Bone Diagnostic Instrument III: Testing Mouse Femora,” Review of Scien n 80(6): 065108 (2009)

u, P, J Xu, M Morris, N Sahar, D Kohn, A Ramamoorthy, “Quantum Dots as Mineral- an fic ain Gauges for Bone Biomechanical Studies,” Proceedings of SPIE 716

hn, DH, ND Sahar, JM Wallace, K Golcuk, MD Morris, “Exercise Alters Mineral a Absence of Adding New Bone,” Cells Tissues Organs 189: 33-37 (2009)

Raghavan, M, MD Morris, ND Sahar, DH olarized Raman Spectroscopy: Application to Bone mechanics,” Proceed (

nsma P, P Turner, B Drake, E Yurtsev, A Proctor, P Mathews, J Lelujian, C Randall, J Adams, R Jungman

Bone Diagnost(2008)

Golcuk, K, GS Mandair, AF Callender, WF Finn an Spectroscopy of Musculoskeletal Tissue Using a Visible Laser and an Elec CD) Detector,” Proceedings of SPIE 6093: 609314 (2006)

Golcuk, K, GS Mandair, AF Callender, ND Sahar, DH Kohn, MD Morris, “Is Photoblea Necessary for Raman Imaging of Bone Tissue Using a Green La (2006)

Kohn, DH, ND Sahar, SI Hong, K Golcuk, MD. Morris

Sahar, N(2005)

Callender, AF, WF Finney, MD Morris, ND Sahar, DH Kohn, KM Kozloff, SA Goldstein, “Dynamic MecTesting System for Raman Microscopy of Bone Tissue Specimens,” Vibrational Spectroscopy 38: 101-105

PRESENTATIONS Sahar, ND, M Raghavan, M Morris, DH Kohn, “Compositional Changes of Bone Mineral and Matrix Have

d on Bone Age,” Annual Meeting of the Orthopaedic

Kohn, “Bone Composition as the Primary Mechanism for Increased tation in Old Mice,” Annual Meeting of the Orthopaedic Research Society,

nd Age on Bone Tissue Quality,”

ctroscopic Study of Compositional Changes in

on and Mechanical Integrity in

e Increases Pre-Yield Mechanical Properties and Damage Resistance in Murine Tibiae,” Annual Meeting of the Orthopaedic Research Society, Chicago, IL (February 2006)

Correlations with Mechanical Properties that May DepenResearch Society, New Orleans, LA (March 2010)

Sahar, ND, K Golcuk, MD Morris, DHSkeletal Fragility and Decreased AdapSan Francisco, CA (February 2008)

Sahar, ND, SR Obreiter, MS Ron, LA Winkel, DH Kohn, “Effects of Exercise aMidwest Tissue Engineering Consortium, Ann Arbor, MI (April 2007)

Golcuk, K, ND Sahar, MD Morris, DH Kohn, “Raman MircrospeMicrodamaged Bone,” Annual Meeting of the Orthopaedic Research Society, San Diego, CA (February 2007)

Sahar, ND, MS Ron, SR Obreiter, DH Kohn, “Exercise Improves CompositiMurine Tibiae,” Midwest Biomedical Engineering Conference, Ann Arbor, MI (March 2006)

Sahar, ND, DH Kohn, K Golcuk, MD Morris, “Effects of Exercise on Bone Quality as Shown by Raman Microspectroscopy,” Annual Meeting of the Orthopaedic Research Society, Chicago, IL (February 2006)

Sahar, ND, MS Ron, SR Obreiter, DH Kohn, “Exercis