curriculum vitae - benaroya research institutewise c, palucka k, ramilo o, punaro m, banchereau j,...

Damien Chaussabel April, 2013

1

Curriculum Vitae

Personal Data

Name: Damien Chaussabel, PhD Address: Office: Benaroya Research Institute 1201 Ninth Ave. Seattle WA 98103 Citizenship: France

Education Graduate:

1995 M. Sc., Biology (with great distinction), University of Brussels (ULB), Belgium. 1999 Ph.D., Immunology (with the highest distinction), Laboratory of Experimental

immunology, University of Brussels (ULB), Belgium. Postgraduate Training 2000 – 2004 Postdoctoral Fellow, National Institute of Allergy and Infectious Diseases,

National Institutes of Health (Bethesda, MD Faculty and Academic Appointments 2000 – 2010 Adjunct Professor, Department of Biomedical Studies, Baylor University,

Waco, TX 2004 – 2008 Assistant Investigator, Baylor Institute for Immunology Research, Dallas,

TX 2009 – 2010 Adjunct Professor, Department of Biomedical Sciences, Baylor College of

Dentistry, Texas A&M University, Dallas, TX 2008 – present Associate Investigator and Director, Center for Personalized Medicine,

Baylor Institute for Immunology Research, Dallas, TX 2010 – present Associate Member and Director, Division of Systems Immunology,

Benaroya Research Institute at Virginia Mason, Seattle, WA Administrative Leadership Appointments 2004 – 2008 Assistant Investigator and Core Director (Microarray/Bioinformatics),

Baylor Institute for Immunology Research, Dallas, TX. 2008 – present Associate Investigator/Core Director (Microarray/Bioinformatics) and

Director, Center for Personalized Medicine, Baylor Institute for Immunology Research, Dallas, TX.

Honors and Awards 1995 Paul Brien Award for best graduate. 2001 Best presentation, Fifth Woods Hole, MA, Immunoparasitology Conference Professional Organizations American Association of Immunologists


2

Patents Blood Transcriptional Signature of Active versus Latent Mycobacterium Tuberculosis Infection Filed: 6/25/08 Priority Application Serial # 61/075,728

Status: Issued SA, NZ (other wise Pending US and worldwide)

Genomic Transcriptional Analysis as a Tool for Identification of Pathogenic Diseases Filed: 5/12/11 Priority Application Serial # 61/334,063

Status: Published US20110312521 Unique Transcriptional Signatures in the Blood of Clinical Responders Filed: 9/13/11 Priority Application Serial # 61/533,932

Status: Pending Teaching / Mentoring Postdocs:

2008-2010 Aaia Alsina Manrique de Lara Baylor Institute for Immunology Research

2006-Current Jason Skinner Baylor Institute for Immunology Research

2008-Current Mamta Sharma Baylor Institute for Immunology Research

2009-Current Lisa Israelsson Benaroya Research Institute

2010-Current Prasong Khaenam Benaroya Research Institute

2011-Current Shinobu Yamamoto Benaroya Research Institute

2011-Current Catherine Speake Benaroya Research Institute

2011-Current Laurent Chiche Benaroya Research Institute

2011-Current Noemie Jourde Benaroya Research Institute Publications 1. Jacobs F, Chaussabel D, Truyens C, Leclerq V, Carlier Y, Goldman M, Vray B. IL-10 up-regulates nitric

oxide (NO) synthesis by lipopolysaccharide (LPS)-activated macrophages: improved control of Trypanosoma cruzi infection. Clin Exp Immunol. 1998 Jul;113(1):59-64. PubMed PMID: 9697984, PMCID: PMC1905023.

2. Chaussabel D, Jacobs F, de Jonge J, de Veerman M, Carlier Y, Thielemans K, Goldman M, Vray B. CD40 ligation prevents Trypanosoma cruzi infection through interleukin-12 upregulation. Infect Immun. 1999 Apr;67(4):1929-34. PubMed PMID: 10085038, PMCID: PMC96548.

3. Chaussabel D, Sher A. Mining microarray expression data by literature profiling. Genome Biol. 2002 Sep 13;3(10):RESEARCH0055. PubMed PMID: 12372143, PMCID: PMC134484.

4. Chaussabel D, Semnani RT, McDowell MA, Sacks D, Sher A, Nutman TB. Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites. Blood. 2003 Jul 15;102(2):672-81. PubMed PMID: 12663451.

5. Edwards AD, Chaussabel D, Tomlinson S, Schulz O, Sher A, Reis e Sousa C. Relationships among murine CD11c(high) dendritic cell subsets as revealed by baseline gene expression patterns. J Immunol. 2003 Jul 1;171(1):47-60. PubMed PMID: 12816982.

6. Chaussabel D, Pajak B, Vercruysse V, Bisseye C, Garze V, Habib M, Goldman M, Moser M, Vray B. Alteration of migration and maturation of dendritic cells and T-cell depletion in the course of experimental Trypanosoma cruzi infection. Lab Invest. 2003 Sep;83(9):1373-82. PubMed PMID: 13679445.

7. Bafica A, Scanga CA, Schito M, Chaussabel D, Sher A. Influence of coinfecting pathogens on HIV expression: evidence for a role of Toll-like receptors. J Immunol. 2004 Jun 15;172(12):7229-34. PubMed PMID: 15187096.


3

8. Chaussabel D. Biomedical literature mining: challenges and solutions in the 'omics' era. Am J Pharmacogenomics. 2004;4(6):383-93. PubMed PMID: 15651899.

9. Yordy JS, Moussa O, Pei H, Chaussabel D, Li R, Watson DK. SP100 inhibits ETS1 activity in primary endothelial cells. Oncogene. 2005 Jan 27;24(5):916-31. PubMed PMID: 15592518.

10. Chaussabel D, Banchereau J. Dendritic cells, therapeutic vectors of immunity and tolerance. Am J Transplant. 2005 Feb;5(2):205-6. PubMed PMID: 15643979.

11. Chaussabel D, Allman W, Mejias A, Chung W, Bennett L, Ramilo O, Pascual V, Palucka AK, Banchereau J. Analysis of significance patterns identifies ubiquitous and disease-specific gene-expression signatures in patient peripheral blood leukocytes. Ann N Y Acad Sci. 2005 Dec;1062:146-54. PubMed PMID: 16461797.

12. Allantaz F, Chaussabel D, Stichweh D, Bennett L, Allman W, Mejias A, Ardura M, Chung W, Smith E, Wise C, Palucka K, Ramilo O, Punaro M, Banchereau J, Pascual V. Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade. J Exp Med. 2007 Sep 3;204(9):2131-44. PubMed PMID: 17724127, PMCID: PMC2118700.

13. Kaizer EC, Glaser CL, Chaussabel D, Banchereau J, Pascual V, White PC. Gene expression in peripheral blood mononuclear cells from children with diabetes. J Clin Endocrinol Metab. 2007 Sep;92(9):3705-11. PubMed PMID: 17595242.

14. Ramilo O, Allman W, Chung W, Mejias A, Ardura M, Glaser C, Wittkowski KM, Piqueras B, Banchereau J, Palucka AK, Chaussabel D. Gene expression patterns in blood leukocytes discriminate patients with acute infections. Blood. 2007 Mar 1;109(5):2066-77. PubMed PMID: 17105821, PMCID: PMC1801073.

15. Allantaz F, Chaussabel D, Banchereau J, Pascual V. Microarray-based identification of novel biomarkers in IL-1-mediated diseases. Curr Opin Immunol. 2007 Dec;19(6):623-32. PubMed PMID: 18036805, PMCID: PMC2747489.

16. Jackson A, McWilliams C, Kaizer E, Chaussabel D, Glaser C, Noguchi H, Matsumoto S, Levy MF, Naziruddin B. Gene expression profiling of human pancreatic islets undergoing a simulated process of instant blood-mediated inflammatory reaction. Transplant Proc. 2008 Mar;40(2):430-2. PubMed PMID: 18374091.

17. Pascual V, Allantaz F, Patel P, Palucka AK, Chaussabel D, Banchereau J. How the study of children with rheumatic diseases identified interferon-alpha and interleukin-1 as novel therapeutic targets. Immunol Rev. 2008 Jun;223:39-59. PubMed PMID: 18613829, PMCID: PMC2753523.

18. Chaussabel D, Quinn C, Shen J, Patel P, Glaser C, Baldwin N, Stichweh D, Blankenship D, Li L, Munagala I, Bennett L, Allantaz F, Mejias A, Ardura M, Kaizer E, Monnet L, Allman W, Randall H, Johnson D, Lanier A, Punaro M, Wittkowski KM, White P, Fay J, Klintmalm G, Ramilo O, Palucka AK, Banchereau J, Pascual V. A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus. Immunity. 2008 Jul 18;29(1):150-64. PubMed PMID: 18631455, PMCID: PMC2727981.

19. von Bernuth H, Picard C, Jin Z, Pankla R, Xiao H, Ku CL, Chrabieh M, Mustapha IB, Ghandil P, Camcioglu Y, Vasconcelos J, Sirvent N, Guedes M, Vitor AB, Herrero-Mata MJ, Arostegui JI, Rodrigo C, Alsina L, Ruiz-Ortiz E, Juan M, Fortuny C, Yague J, Anton J, Pascal M, Chang HH, Janniere L, Rose Y, Garty BZ, Chapel H, Issekutz A, Marodi L, Rodriguez-Gallego C, Banchereau J, Abel L, Li X, Chaussabel D, Puel A, Casanova JL. Pyogenic bacterial infections in humans with MyD88 deficiency. Science. 2008 Aug 1;321(5889):691-6. PubMed PMID: 18669862, PMCID: PMC2688396.

20. Klechevsky E, Morita R, Liu M, Cao Y, Coquery S, Thompson-Snipes L, Briere F, Chaussabel D, Zurawski G, Palucka AK, Reiter Y, Banchereau J, Ueno H. Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells. Immunity. 2008 Sep 19;29(3):497-510. PubMed PMID: 18789730, PMCID: PMC2688399.

21. Chaussabel D. Translation of genomics research at the bedside: the promise and the challenge. Clin Immunol. 2008 Nov;129(2):179-81. PubMed PMID: 18804420, PMCID: PMC2602964.


4

22. Feng CG, Zheng L, Jankovic D, Bafica A, Cannons JL, Watford WT, Chaussabel D, Hieny S, Caspar P, Schwartzberg PL, Lenardo MJ, Sher A. The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. Nat Immunol. 2008 Nov;9(11):1279-87. PubMed PMID: 18806793, PMCID: PMC2580721.

23. Semnani RT, Venugopal PG, Mahapatra L, Skinner JA, Meylan F, Chien D, Dorward DW, Chaussabel D, Siegel RM, Nutman TB. Induction of TRAIL- and TNF-alpha-dependent apoptosis in human monocyte-derived dendritic cells by microfilariae of Brugia malayi. J Immunol. 2008 Nov 15;181(10):7081-9. PubMed PMID: 18981128.

24. Noguchi H, Matsumoto S, Onaca N, Naziruddin B, Jackson A, Ikemoto T, Shimoda M, Fujita Y, Chujo D, Iwanaga Y, Nagata H, Okitsu T, Kobayashi N, Ueno H, Chaussabel D, Grayburn P, Banchereau J, Levy MF. Ductal injection of JNK inhibitors before pancreas preservation prevents islet apoptosis and improves islet graft function. Hum Gene Ther. 2009 Jan;20(1):73-85. PubMed PMID: 18925829.

25. Luci C, Reynders A, Ivanov, II, Cognet C, Chiche L, Chasson L, Hardwigsen J, Anguiano E, Banchereau J, Chaussabel D, Dalod M, Littman DR, Vivier E, Tomasello E. Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin. Nat Immunol. 2009 Jan;10(1):75-82. PubMed PMID: 19029904.

26. Butterfield LH, Disis ML, Fox BA, Lee PP, Khleif SN, Thurin M, Trinchieri G, Wang E, Wigginton J, Chaussabel D, Coukos G, Dhodapkar M, Hakansson L, Janetzki S, Kleen TO, Kirkwood JM, Maccalli C, Maecker H, Maio M, Malyguine A, Masucci G, Palucka AK, Potter DM, Ribas A, Rivoltini L, Schendel D, Seliger B, Selvan S, Slingluff CL, Jr., Stroncek DF, Streicher H, Wu X, Zeskind B, Zhao Y, Zocca MB, Zwierzina H, Marincola FM. A systematic approach to biomarker discovery; preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers". J Transl Med. 2008;6:81. PubMed PMID: 19105846, PMCID: PMC2630944.

27. Ardura MI, Banchereau R, Mejias A, Di Pucchio T, Glaser C, Allantaz F, Pascual V, Banchereau J, Chaussabel D, Ramilo O. Enhanced monocyte response and decreased central memory T cells in children with invasive Staphylococcus aureus infections. PLoS One. 2009;4(5):e5446. PubMed PMID: 19424507, PMCID: PMC2676512.

28. Matsui T, Connolly JE, Michnevitz M, Chaussabel D, Yu CI, Glaser C, Tindle S, Pypaert M, Freitas H, Piqueras B, Banchereau J, Palucka AK. CD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functions. J Immunol. 2009 Jun 1;182(11):6815-23. PubMed PMID: 19454677, PMCID: PMC2749454.

29. Tahara H, Sato M, Thurin M, Wang E, Butterfield LH, Disis ML, Fox BA, Lee PP, Khleif SN, Wigginton JM, Ambs S, Akutsu Y, Chaussabel D, Doki Y, Eremin O, Fridman WH, Hirohashi Y, Imai K, Jacobson J, Jinushi M, Kanamoto A, Kashani-Sabet M, Kato K, Kawakami Y, Kirkwood JM, Kleen TO, Lehmann PV, Liotta L, Lotze MT, Maio M, Malyguine A, Masucci G, Matsubara H, Mayrand-Chung S, Nakamura K, Nishikawa H, Palucka AK, Petricoin EF, Pos Z, Ribas A, Rivoltini L, Sato N, Shiku H, Slingluff CL, Streicher H, Stroncek DF, Takeuchi H, Toyota M, Wada H, Wu X, Wulfkuhle J, Yaguchi T, Zeskind B, Zhao Y, Zocca MB, Marincola FM. Emerging concepts in biomarker discovery; the US-Japan Workshop on Immunological Molecular Markers in Oncology. J Transl Med. 2009;7:45. PubMed PMID: 19534815, PMCID: PMC2724494.

30. Pankla R, Buddhisa S, Berry M, Blankenship DM, Bancroft GJ, Banchereau J, Lertmemongkolchai G, Chaussabel D. Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis. Genome Biol. 2009;10(11):R127. PubMed PMID: 19903332, PMCID: PMC3091321.

31. Chaussabel D, Ueno H, Banchereau J, Quinn C. Data management: it starts at the bench. Nat Immunol. 2009 Dec;10(12):1225-7. PubMed PMID: 19915619, PMCID: PMC2788787.

32. Ceppi M, Clavarino G, Gatti E, Schmidt EK, de Gassart A, Blankenship D, Ogola G, Banchereau J, Chaussabel D, Pierre P. Ribosomal protein mRNAs are translationally-regulated during human


5

dendritic cells activation by LPS. Immunome Res. 2009;5:5. PubMed PMID: 19943945, PMCID: PMC2788525.

33. Assassi S, Mayes MD, Arnett FC, Gourh P, Agarwal SK, McNearney TA, Chaussabel D, Oommen N, Fischbach M, Shah KR, Charles J, Pascual V, Reveille JD, Tan FK. Systemic sclerosis and lupus: points in an interferon-mediated continuum. Arthritis Rheum. 2010 Feb;62(2):589-98. PubMed PMID: 20112391, PMCID: PMC2879587.

34. Pascual V, Chaussabel D, Banchereau J. A genomic approach to human autoimmune diseases. Annu Rev Immunol. 2010;28:535-71. PubMed PMID: 20192809, PMCID: PMC2847838.

35. Guiducci C, Gong M, Xu Z, Gill M, Chaussabel D, Meeker T, Chan JH, Wright T, Punaro M, Bolland S, Soumelis V, Banchereau J, Coffman RL, Pascual V, Barrat FJ. TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus. Nature. 2010 Jun 17;465(7300):937-41. PubMed PMID: 20559388, PMCID: PMC2964153.

36. Chaussabel D, Pascual V, Banchereau J. Assessing the human immune system through blood transcriptomics. BMC Biol. 2010;8:84. PubMed PMID: 20619006, PMCID: PMC2895587.

37. Berry MP, Graham CM, McNab FW, Xu Z, Bloch SA, Oni T, Wilkinson KA, Banchereau R, Skinner J, Wilkinson RJ, Quinn C, Blankenship D, Dhawan R, Cush JJ, Mejias A, Ramilo O, Kon OM, Pascual V, Banchereau J, Chaussabel D, O'Garra A. An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature. 2010 Aug 19;466(7309):973-7. PubMed PMID: 20725040, PMCID: PMC3492754.

38. Kong XF, Ciancanelli M, Al-Hajjar S, Alsina L, Zumwalt T, Bustamante J, Feinberg J, Audry M, Prando C, Bryant V, Kreins A, Bogunovic D, Halwani R, Zhang XX, Abel L, Chaussabel D, Al-Muhsen S, Casanova JL, Boisson-Dupuis S. A novel form of human STAT1 deficiency impairing early but not late responses to interferons. Blood. 2010 Dec 23;116(26):5895-906. PubMed PMID: 20841510, PMCID: PMC3031383.

39. Quartier P, Allantaz F, Cimaz R, Pillet P, Messiaen C, Bardin C, Bossuyt X, Boutten A, Bienvenu J, Duquesne A, Richer O, Chaussabel D, Mogenet A, Banchereau J, Treluyer JM, Landais P, Pascual V. A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial). Ann Rheum Dis. 2011 May;70(5):747-54. PubMed PMID: 21173013, PMCID: PMC3070271.

40. Matsumoto S, Takita M, Chaussabel D, Noguchi H, Shimoda M, Sugimoto K, Itoh T, Chujo D, SoRelle J, Onaca N, Naziruddin B, Levy MF. Improving efficacy of clinical islet transplantation with iodixanol-based islet purification, thymoglobulin induction, and blockage of IL-1beta and TNF-alpha. Cell Transplant. 2011;20(10):1641-7. PubMed PMID: 21396171.

41. McNab FW, Berry MP, Graham CM, Bloch SA, Oni T, Wilkinson KA, Wilkinson RJ, Kon OM, Banchereau J, Chaussabel D, O'Garra A. Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis. Eur J Immunol. 2011 Jul;41(7):1941-7. PubMed PMID: 21509782, PMCID: PMC3179592.

42. Hambleton S, Salem S, Bustamante J, Bigley V, Boisson-Dupuis S, Azevedo J, Fortin A, Haniffa M, Ceron-Gutierrez L, Bacon CM, Menon G, Trouillet C, McDonald D, Carey P, Ginhoux F, Alsina L, Zumwalt TJ, Kong XF, Kumararatne D, Butler K, Hubeau M, Feinberg J, Al-Muhsen S, Cant A, Abel L, Chaussabel D, Doffinger R, Talesnik E, Grumach A, Duarte A, Abarca K, Moraes-Vasconcelos D, Burk D, Berghuis A, Geissmann F, Collin M, Casanova JL, Gros P. IRF8 mutations and human dendritic-cell immunodeficiency. N Engl J Med. 2011 Jul 14;365(2):127-38. PubMed PMID: 21524210, PMCID: PMC3136554.

43. Guo Y, Audry M, Ciancanelli M, Alsina L, Azevedo J, Herman M, Anguiano E, Sancho-Shimizu V, Lorenzo L, Pauwels E, Philippe PB, Perez de Diego R, Cardon A, Vogt G, Picard C, Andrianirina ZZ, Rozenberg F, Lebon P, Plancoulaine S, Tardieu M, Valerie D, Jouanguy E, Chaussabel D, Geissmann F, Abel L, Casanova JL, Zhang SY. Herpes simplex virus encephalitis in a patient with complete TLR3


6

deficiency: TLR3 is otherwise redundant in protective immunity. J Exp Med. 2011 Sep 26;208(10):2083-98. PubMed PMID: 21911422, PMCID: PMC3182056.

44. Sancho-Shimizu V, Perez de Diego R, Lorenzo L, Halwani R, Alangari A, Israelsson E, Fabrega S, Cardon A, Maluenda J, Tatematsu M, Mahvelati F, Herman M, Ciancanelli M, Guo Y, AlSum Z, Alkhamis N, Al-Makadma AS, Ghadiri A, Boucherit S, Plancoulaine S, Picard C, Rozenberg F, Tardieu M, Lebon P, Jouanguy E, Rezaei N, Seya T, Matsumoto M, Chaussabel D, Puel A, Zhang SY, Abel L, Al-Muhsen S, Casanova JL. Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency. J Clin Invest. 2011 Dec;121(12):4889-902. PubMed PMID: 22105173, PMCID: PMC3226004.

45. Tattermusch S, Skinner JA, Chaussabel D, Banchereau J, Berry MP, McNab FW, O'Garra A, Taylor GP, Bangham CR. Systems biology approaches reveal a specific interferon-inducible signature in HTLV-1 associated myelopathy. PLoS Pathog. 2012 Jan;8(1):e1002480. PubMed PMID: 22291590, PMCID: PMC3266939.

46. Ioannidis I, McNally B, Willette M, Peeples ME, Chaussabel D, Durbin JE, Ramilo O, Mejias A, Flano E. Plasticity and virus specificity of the airway epithelial cell immune response during respiratory virus infection. J Virol. 2012 May;86(10):5422-36. PubMed PMID: 22398282, PMCID: PMC3347264.

47. Banchereau R, Jordan-Villegas A, Ardura M, Mejias A, Baldwin N, Xu H, Saye E, Rossello-Urgell J, Nguyen P, Blankenship D, Creech CB, Pascual V, Banchereau J, Chaussabel D, Ramilo O. Host immune transcriptional profiles reflect the variability in clinical disease manifestations in patients with Staphylococcus aureus infections. PLoS One. 2012;7(4):e34390. PubMed PMID: 22496797, PMCID: PMC3319567.

48. Chang HH, Soderberg K, Skinner JA, Banchereau J, Chaussabel D, Haynes BF, Ramoni M, Letvin NL. Transcriptional network predicts viral set point during acute HIV-1 infection. J Am Med Inform Assoc. 2012 Nov-Dec;19(6):1103-9. PubMed PMID: 22700869, PMCID: PMC3534464.

49. Herman M, Ciancanelli M, Ou YH, Lorenzo L, Klaudel-Dreszler M, Pauwels E, Sancho-Shimizu V, Perez de Diego R, Abhyankar A, Israelsson E, Guo Y, Cardon A, Rozenberg F, Lebon P, Tardieu M, Heropolitanska-Pliszka E, Chaussabel D, White MA, Abel L, Zhang SY, Casanova JL. Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood. J Exp Med. 2012 Aug 27;209(9):1567-82. PubMed PMID: 22851595, PMCID: PMC3428952.

50. Jackson AM, Kanak MA, Grishman EK, Chaussabel D, Levy MF, Naziruddin B. Gene expression changes in human islets exposed to type 1 diabetic serum. Islets. 2012 Jul-Aug;4(4):312-9. PubMed PMID: 22885994, PMCID: PMC3496656.

51. Rinchai D, Khaenam P, Kewcharoenwong C, Buddhisa S, Pankla R, Chaussabel D, Bancroft GJ, Lertmemongkolchai G. Production of interleukin-27 by human neutrophils regulates their function during bacterial infection. Eur J Immunol. 2012 Dec;42(12):3280-90. PubMed PMID: 22965735.

52. Bloom CI, Graham CM, Berry MP, Wilkinson KA, Oni T, Rozakeas F, Xu Z, Rossello-Urgell J, Chaussabel D, Banchereau J, Pascual V, Lipman M, Wilkinson RJ, O'Garra A. Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy. PLoS One. 2012;7(10):e46191. PubMed PMID: 23056259, PMCID: PMC3462772.

53. Boisson B, Laplantine E, Prando C, Giliani S, Israelsson E, Xu Z, Abhyankar A, Israel L, Trevejo-Nunez G, Bogunovic D, Cepika AM, MacDuff D, Chrabieh M, Hubeau M, Bajolle F, Debre M, Mazzolari E, Vairo D, Agou F, Virgin HW, Bossuyt X, Rambaud C, Facchetti F, Bonnet D, Quartier P, Fournet JC, Pascual V, Chaussabel D, Notarangelo LD, Puel A, Israel A, Casanova JL, Picard C. Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency. Nat Immunol. 2012 Dec;13(12):1178-86. PubMed PMID: 23104095, PMCID: PMC3514453.

54. Kong XF, Vogt G, Itan Y, Macura-Biegun A, Szaflarska A, Kowalczyk D, Chapgier A, Abhyankar A, Furthner D, Djambas Khayat C, Okada S, Bryant VL, Bogunovic D, Kreins A, Moncada-Velez M, Migaud M, Al-Ajaji S, Al-Muhsen S, Holland SM, Abel L, Picard C, Chaussabel D, Bustamante J, Casanova JL, Boisson-Dupuis S. Haploinsufficiency at the human IFNGR2 locus contributes to


7

mycobacterial disease. Hum Mol Genet. 2013 Feb 15;22(4):769-81. PubMed PMID: 23161749, PMCID: PMC3554203.

55. Rabinowitz KM, Wang Y, Chen EY, Hovhannisyan Z, Chiang D, Berin MC, Dahan S, Chaussabel D, Ma'ayan A, Mayer L. Transforming Growth Factor beta Signaling Controls Activities of Human Intestinal CD8(+)T Suppressor Cells. Gastroenterology. 2013 Mar;144(3):601-12 e1. PubMed PMID: 23232296.

56. Chujo D, Foucat E, Nguyen TS, Chaussabel D, Banchereau J, Ueno H. ZnT8-Specific CD4+ T cells display distinct cytokine expression profiles between type 1 diabetes patients and healthy adults. PLoS One. 2013;8(2):e55595. PubMed PMID: 23390544, PMCID: PMC3563599.

57. Boyd A, Bennuru S, Wang Y, Sanprasert V, Law M, Chaussabel D, Nutman TB, Semnani RT. Quiescent Innate Response to Infective Filariae by Human Langerhans Cells Suggests a Strategy of Immune Evasion. Infect Immun. 2013 Feb 19. PubMed PMID: 23429540.

58. Chiche L, Jourde-Chiche N, Pascual V, Chaussabel D. A&R special issue: Disease mechanisms in rheumatology: Tools and pathways. Arthritis Rheum. 2013 Feb 28. PubMed PMID: 23450649.

59. Obermoser G, Presnell S, Domico K, Xu H, Wang Y, Anguiano E, Thompson-Snipes L, Ranganathan R, Zeitner B, Bjork A, Anderson D, Speake C, Ruchaud E, Skinner J, Alsina L, Sharma M, Dutartre H, Cepika A, Israelsson E, Nguyen P, Nguyen QA, Harrod AC, Zurawski SM, Pascual V, Ueno H, Nepom GT, Quinn C, Blankenship D, Palucka K, Banchereau J, Chaussabel D. Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines. Immunity. 2013 Apr 18;38(4):831-44. PubMed PMID: 23601689.

Invited Lectures/Presentations 2001

CRANIOFACIAL & SKELETAL DISEASES BRANCH, NIDCR How To Make the Best Use of Microarrays For Your Research, A Guide for New Users, Based On a True Story Invited Speaker March 8 2001, Bethesda MD

FOUNDATION FOR ADVANCED EDUCATION IN THE SCIENCES Microarray Technology Invited Lecturer April 12, 2001, Bethesda MD

FIFTH WOODS HOLE IMMUNOPARASITOLOGY CONFERENCE Global Gene Expression Analysis in Macrophages and Dendritic Cells, in Response to Intracellular and Extracellular Pathogens, Part I : A Field guide to Microarray technology Selected oral presentation April 22-25 2001, Woods Hole MA

UNIVERSITY OF PENNSYLVANIA: PARASITOLOGY GRADUATE GROUP SEMINAR SERIES Profiling the response of human dendritic cells and macrophages to phylogenetically distinct pathogens - Or how to manage data generated by gene expression microarrays Invited Speaker October 8 2001, Philadelphia PA

NIH IMMUNOLOGY RETREAT Global gene expression analysis reveals common patterns of gene expression induced by Mycobacterium tuberculosis and Toxoplasma gondii in human dendritic cells Selected oral presentation October 23 2001, Warrenton VA


8

2002

IGEN INTERNATIONAL INC. Mining microarray expression data by literature profiling Invited Speaker March 27 2002, Gaithersburg MD

NIAID BIOINFORMATICS SEMINAR SERIES Making sense of microarray gene expression data: the meaning is in the literature Invited Speaker September 12 2002, Bethesda MD

MEDICAL COLLEGE OF GEORGIA Finding Meaning in Microarrays Through the Combination of Gene Expression and Literature Profiling Strategies: Global-Scale Characterization of the Innate Immune Response to Infection in Human Macrophages and Dendritic Cells Invited Speaker September 20 2002, Augusta GA

GEORGE WASHINGTON UNIVERSITY: INTRODUCTION TO BIOINFORMATICS Nucleotide and protein databases Invited Lecturer September 30 2002, Washington DC

2003

GEORGE WASHINGTON UNIVERSITY: BIOCHEMISTRY COURSE - FUNDAMENTALS OF GENOMICS AND PROTEOMICS Literature mining Invited Lecturer March 25 2003, Washington DC

NESTLE RESEARCH CENTER Mining microarray gene expression data: the meaning is in the literature Invited Speaker April 1 2003, Lausanne, Switzerland

DUKE UNIVERSITY: MATHEMATICAL MODELING IN BIOLOGY WORKSHOP Making sense of microarray studies: the meaning is in the literature Invited Speaker May 1-2 2003, Durham NC

MARCUS EVANS: MICROARRAY ANALYSIS / VISUALIZATION AND INTEGRATION CONFERENCE Mapping Functional Relationships Among Clusters of Co-regulated Genes by Literature Profiling Invited Speaker May 20-22, 2003, Boston MA

FREDERICK FORUM ON BIOINFORMATICS AND CHEMOINFORMATICS Profiling the biomedical literature: microarrays and beyond Invited Speaker June 24 2003, Frederick MD

CAMBRIDGE HEALTHTECH INSTITUTE: DATA VISUALIZATION AND INTERPRETATION CONFERENCE Knowledge extraction in the “Omics” era: the meaning is in the literature Invited Speaker September 24-25 2003, Baltimore MD


9

2004

18TH CONFERENCE OF THE EUROPEAN MACROPHAGE AND DENDRITIC CELL SOCIETY Gene expression patterns in blood leukocytes discriminate the class of pathogen Invited speaker October 14-16, 2004, Barcelona, Spain

BAYLOR INSTITUTE FOR IMMUNOLOGY RESEARCH: HUMAN IMMUNOLOGY AND BIODEFENSE WORKSHOP Literature mining tools for knowledge discovery in microarray data November 7, 2004, Dallas, TX

2005

NEW YORK ACADEMY OF SCIENCES SYMPOSIUM ON HUMAN IMMUNOLOGY AND PATIENT-BASED RESEARCH Genes of Health Invited speaker May 17, 2005, New York, NY

2006

MD ANDERSON CANCER CENTER Clinical application of robust microarray transcriptional markers measured in patient blood. January 06 2006, Houston, TX

2007

NHLBI SYSTEMS MEDICINE WORKSHOP Bridging the Gap between Genome-wide Patient Studies February 01 2007, Bethesda, MD

AMERICAN DIABETES ASSOCIATION 67TH SCIENTIFIC SESSIONS Microarray Analysis in Autoimmunity Invited speaker June 22, 2007, Chicago, IL

2008

8TH ANNUAL RACHMIEL LEVINE SYMPOSIUM: “Translational Research in Type 1 “Translational Research in Type 1 Diabetes: Beyond Insulin and the Edmonton Protocol” Microarray analysis of autoimmunity: Can we learn more? Invited speaker January 13-16, 2008, Newport Beach, CA

KEYSTONE SYMPOSIUM: BIOMARKER DISCOVERY, VALIDATION AND APPLICATIONS Analysis of Disease Signatures in Gene Expression Profiles from Peripheral Blood Leukocytes. Invited Speaker February 3-8, 2008, Tahoe City, CA

MD ANDERSON CANCER CENTER BIOINFORMATICS WORKSHOP A Modular Framework for Biomarker and Knowledge Discovery from Blood Transcriptional Profiling Studies Invited speaker May 19, 2008, Houston, TX

NHLBI IMMUNO-GENETICS AND IMMNO-PHENOTYPES OF CHRONIC LUNG DISEASE


10

WORKSHOP Translational Systems Biology September 25, 2008, Bethesda, MD

NIAID BIOINFORMATICS SUMMIT Translational Bioinformatics: Challenges and Solutions for Data Integration and Biomarker Discovery Invited speaker October 20-21, 2008, Rockville, MD

48TH ICAAC/IDSA 46TH ANNUAL MEETING Host Transcriptome Analysis in HIV Disease Invited speaker October 25-28, 2008, Washington DC

2009

MOUNT SINAI January 8-9, 2009, New York, NY

2009 GORDON RESEARCH CONFERENCE: CHEMICAL & BIOLOGICAL TERRORISM DEFENSE January 21-22, 2009, Galveston, TX

BAYLOR COLLEGE OF MEDICINE January 26-27, 2009, Houston, TX

2ND SCRIPPS GENOMICS January 30-31, 2009, San Diego, CA

NIH:US JAPAN MEETING ON IMMUNOTHERAPY MARKERS IN ONCOLOGY PROGRESS AND CHALLENGES Invited speaker March 23-24, 2009, Waikoloa, HI

FEDERATION OF CLINICAL IMMUNOLOGY SOCIETY MEETING June 11-14, 2009, San Francisco, CA

CENTER FOR HUMAN IMMUNOLOGY VISIT/LECTURE SERIES Invited Speaker July 29-30, 2009, Washington, DC

AMERICAN INSTITUTE FOR RESEARCH Getting From Genes to Function in Lung Disease Workshop Invited Speaker September 3-4, 2009, Bethesda, MD

INTERNATIONAL SOCIETY FOR BIOLOGICAL THERAPY OF CANCER, INC. October 28-29, 2009, Washington, DC 2010

SYMPOSIUM ON INFECTION AND IMMUNITY Thailand, China, January 4-14, 2010

SYSTEMS BIOLOGY AND HIV VACCINE DEVELOPMENT CONFERENCE Invited speaker Peachtree, GA, February 8-10, 2010

JDRF AUTOIMMUNITY CENTER CONSORTIUM RETREAT New York, NY, March 1-3, 2010

ADVANCED TECHNOLOGIES IN IMMUNOMONITORING: FROM BASIC RESEARCH TO CLINICAL TRIALS Invited speaker Fontenay aux Roses, France, March 29-30, 2010


11

HIGH THROUGHPUT APPROACHES IN INFECTION AND IMMUNITY WORKSHOP Cha-am and Hua Hin, Thailand, December 6-10, 2010

2011

TRANS-NIH CENTER FOR HUMAN IMMUNOLOGY, AUTOIMMUNITY AND INFLAMMATION Invited speaker Bethesda, MD, February 14-15, 2011

GRAND ROUNDS, VIRGINIA MASON MEDICAL CENTER Seattle, WA, February 25, 2011

3rd NIH/SCRIPPS GENOMICS WORKSHOP, GENOMICS, PROTEOMICS AND GENETICS FOR TRANSPLANTATION: DICOVERY, CHALLENGES AND EVOLVING TECHNOLOGIES Invited speaker La Jolla, CA, March 18, 2011

MERCK VACCINES RESEARCH MINI-SYMPOSIUM: LAUNCH OF THE NIH HUMAN IMMUNOLOGY PROJECT CONSORTIUM Invited speaker West Point, PA, March 30, 2011

MRC NATIONAL INSTITUTE FOR MEDICAL RESEARCH Invited Speaker London, UK, April 10-14, 2011

THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS 98th ANNUAL MEETING San Francisco, CA, May 13-17, 2011

5th PASTEUR-AREVA COURSE ON INFLAMMATION AND VACCINE Shanghai, China, May 27-29, 2011

NOVO NORDISK, ROUNDTABLE SEMINAR: ASSESSING IMMUNE FUNCTION USING BLOOD GENOMIC APPROACHES Invited speaker Seattle, WA July 6, 2011

ITN Research Forum ITN via Web Seattle WA, August 20, 2011

49TH ANNUAL MEETING OF THE INFECTIOUS DISEASES SOCIIETY OF AMERICA AND THE HIV MEDICINE ASSOCATION, Boston, MA October 20th-23rd, 2011 2012

SYSTEMS IMMUNOLOGY MEETING, THE GATES FOUNDATION Invited Speaker Bethesda, MD April 16th

NIH TWINBROOK SEMINAR SERIES, SYSTEMS APPROACHES TO HUMAN IMMUNOLOGY, Invited Speaker Bethesda, MD April 17-18th

AGING AND IMMUNITY CONFERENCE, THE FOUNDATION MERIEUX, Invited Speaker Siena, Italy, April 23-25

NOVO NORDISK T1D SCIENTIFIC SYMPOSIUM Invited Speaker Seattle, WA, June 14th


12

HUMAN IMMUNOLOGYPROJECT CONSORTIUM SEMI-ANNUAL MEETING Invited Speaker & Participant Bethesda, MD, July 9th-11th 2012

INDO-US SYMPOSIUM ON “HUMAN IMMUNITY AND INFECTIOUS DISEASE” Speaker and Moderator Delhi, India, Sept 4th & 5th

WELLCOME TRUST STRATEGIC AWARDS COMMITTEE External Adviser London, UK, Oct.15th

curriculum vitae - benaroya research institutewise c, palucka k, ramilo o, punaro m, banchereau j,...

Documents