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CURRICULUM VITAE Claudia Kappen, Dr. rer. nat. Address: Pennington Biomedical Research Center 6400 Perkins Road Baton Rouge, LA 70808 (225) 763-2781 e-mail: claudia.kappen@pbrc.edu Home Contact: e-mail: claudiakappen@cox.net Birth Date: April 5th, 1958 Nationality: Dual Citizenship: United States and Germany (FRG) Present Position: since 2007 Professor Peggy M. Pennington Cole Endowed Chair in Developmental Biology Pennington Biomedical Research Center, Louisiana State University Baton Rouge, LA since 2013 TeratOmic Consulting, Austin, TX; consulting for legal teams Prior Employment: 2000 - 2007 Professor (2006 - 2007), Associate Professor (2000 - 2006), Department of Genetics, Cell Biology and Anatomy, Scientist (2000 - 2007), Munroe-Meyer Institute (Center for Hum. Mol. Genetics 2000 - 2003) University of Nebraska Medical Center, Omaha, NE, USA 1999 - 2000 Adjunct Professor, Department of Molecular and Cell Biology University of Arizona, Tucson, AZ, USA 1997 - 2000 Adjunct Professor, Molecular and Cell Biology Graduate Program, Arizona State University, Tempe, AZ, USA 1992 - 2000 Senior Associate Consultant (1994 - 2000), Associate Consultant (1992 - 1994) Mayo Clinic Scottsdale, Scottsdale, AZ, USA Assistant Professor, Mayo Graduate and Medical Schools Department of Biochemistry and Molecular Biology and Molecular Neuroscience Program, Mayo Clinic, Rochester, MN

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Claudia Kappen, Dr. rer. nat. Prior Employment: (continued) 1988 - 1992 Postdoctoral Associate (1990 - 1992) Postdoctoral Fellow (1988 - 1990) Laboratory of Prof. F.H. Ruddle, Department of Biology, Yale University, New Haven, CT, USA 1987 - 1988 Lecturer at the University of Essen, Federal Republic of Germany 1982 - 1988 Research Scientist (1985 - 1988) Research Assistant (1982 - 1985) Laboratory of Prof. Dr. K. Rajewsky, Institute for Genetics, University of Cologne, Federal Republic of Germany Education: 1987 Dr. rer. nat., Universität zu Köln, Federal Republic of Germany Title of the dissertation thesis: "Investigations on the cellular basis of B cell memory in the mouse" 1983 M. Sc., Universität zu Köln, Federal Republic of Germany Title of the thesis: "Investigations on the localization of idiotypic determinants on variable regions of antibodies" 1979 - 1983 Biology (major) and Philosophy (minor), Universität zu Köln Research Grant Awards: Grants Pending: 2014 - 2019 "Epigenetic Mechanisms in Neural Tube Defects" (PI: C. Kappen) NICHD R01, $ 250,000/year direct cost 2014 - 2019 "Molecular Basis for Partial Penetrance of Neural Tube Defects" (PI: C. Kappen) NICHD R01, $ 250,000/year direct cost 2013 - 2017 "Epigenomic and Transcriptional Responses to Exposures in the Intrauterine

Environment" (PI: C. Kappen) NIEHS R01, $ 450,000/year direct cost

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Claudia Kappen, Dr. rer. nat. Research Grants: Previous awards: 2010 - 2012 "Molecular Mechanisms in Diabetic Embryopathy" – ARRA administrative

supplement (PI: C. Kappen) NICHD R01, $ 150,000/year direct cost (in no-cost extension) 1998 - 2011 "Molecular Mechanisms in Diabetic Embryopathy" (PI: C. Kappen) NICHD R01, $ 225,000/year direct cost (with no-cost extension) 2007 - 2011 "Neural Tube Defects in Diabetic Pregnancies" (PI: J.M. Salbaum) NIH R01, $ 250,000/year, C. Kappen as Co-PI, 10% effort (in no-cost extension) 2005 - 2008 "Genetic dissection of skeletal patterning" (PI: C. Kappen) NIAMS R21, $ 150,000/year direct cost 2003 - 2008 "Center for Molecular Biology of the Neurosensory System" (PI: S. Smith) C. Kappen as Core Director (Histology Core; 10% effort) NIH-NCRR COBRE, $ 1.5 Mio./year direct cost

2005 - 2007 Supplement to NICHD-R01 to support re-entry into biomedical research career

for Dr. Gabriela Pavlinkova, $ 75,000/year (supervising PI: C. Kappen) 2004 - 2006 "Analysis of folate receptor 4 function in the mouse" (PI: J.M. Salbaum) NICHD R21, $ 125,000/year direct cost, C. Kappen as Co-PI, 10% effort

2005 - 2006 Dean's Indirect cost award, University of Nebraska College of Medicine, $ 30,000/year direct cost for one year (PI: C. Kappen) 2003 - 2006 "Molecular basis of tobacco's effect on the developing skeleton and possible

beneficial role of folic acid" (PI: C. Kappen) Phillip Morris External Research Program, $ 150.000/year direct cost 2002 - 2005 "Genome-wide discovery of beta-cell gene control elements” (PI: C. Kappen)

NIDDK R01, $ 400,000/year direct cost (Co-PIs: J.M. Salbaum, C.J. Stoeckert/University of Pennsylvania, E. Rubin/J-F. Cheng/Lawrence Berkeley National Laboratory)

2002 - 2005 "Molecular basis of Isl-1 induced birth defects” (Hong Khan Bao Dinh) NRSA/NICHD/NIDDK Postdoctoral Fellowship (supervising PI: C. Kappen) 2002 - 2004 "Folate and Hox Genes in Craniofacial Development" (PI: C. Kappen) NIDCR R21, $ 100,000/year direct cost 2000 - 2004 "Development of Transgenic Animal Models for Studies of Complex Congenital

Defects", (PI: C. Kappen; Co-PI's: Y. Ma, J.M. Salbaum) Nebraska Research Initiative $ 250,000/year; $ 80,000 for my subproject

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Claudia Kappen, Dr. rer. nat. Research Grant Awards: Previous Awards (continued): 2001 - 2003 "Functional Genomics of Cartilage Development" (PI: C. Kappen) Aircast Foundation, $ 50,000/year 2002 Selected for High-Priority sequencing in the Mouse Genome Sequencing Project

for intermediate coverage of two BACs of 250 kb of the mouse Isl-1 locus (PI: C. Kappen) by the Harvard Genome Center, cost supported by NHGRI, estimated value: $ 125,000

2002 Selected for High-Priority sequencing in the Mouse Genome Sequencing Project

for complete coverage of two BACs of 250 kb of the murine Punc locus (PI: J.M. Salbaum, C. Kappen as Co-PI) by the Harvard Genome Center, cost supported by NHGRI, estimated value: $ 125,000

2000 - 2003 "A candidate gene for the fourth form of Bardet-Biedl Syndrome (BBS4)" (PI: C.

Kappen) March Dimes Birth Defects Foundation, $ 75,000/year direct cost 2000 - 2002 "Novel gene control elements in genitourinary development" (PI: J.M. Salbaum), C. Kappen as Co-PI with 10% effort NIDDK-R21$ 100,000/year direct cost 1998 - 2002 "Molecular mechanisms in diabetic embryopathy" (PI: C. Kappen) NICHD R01, $ 251,970 direct cost in the last year; $ 1.2 Mio. total direct cost 1999 - 2002 "Role of Hoxc-8 in the Development of Cartilage" (Stephania Cormier-Regard) NRSA/NIAMS Postdoctoral Fellowship (supervising PI: C. Kappen) 1999 "Role of Hoxc-8 in the Development of Cartilage" (Stephania Cormier-Regard) Postdoctoral Fellowship, Arthritis Foundation, $35,000/year for two years (was declined in favor of the NRSA) (supervising PI: C. Kappen) 1997 - 2001 "Molecular Basis of Abnormal Cartilage and Bone In Vivo" (PI: C. Kappen) Arthritis Foundation, $ 75,000/year 1997 - 2001 "Transcriptional Regulation in Cartilage Precursor Cells" (PI: C. Kappen) NIAMS R03, $ 50,000/year 1997 -1999 "Smokeless Tobacco's Effect on the Developing Fetus: Molecular Analysis of

Abnormal Skeletal Development" (PI: C. Kappen), Smokeless Tobacco Research Council, replaced by Mayo Foundation to comply with institutional policy, $ 80,000/year

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Claudia Kappen, Dr. rer. nat. Research Grant Awards: Previous Awards (continued): 1996 - 1999 "Novel TGF-ß inducible gene in human osteoblasts" (PI: Thomas C. Spelsberg),

C. Kappen as Co-PI with 15% effort and salary and $ 6,000 supplies/year 1997 Gift to Mayo Clinic Arizona for Research into Developmental Defects, $ 50,000 1997 Mayo Anesthesiology Training Grant (to D. Zacharias, Ph.D.), $ 50,000 for 1 year (supervising PI: C. Kappen) 1996 - 1997 Contract with Midwestern University (Glendale, AZ), funding for supplies for

Visiting Scientist: D.P. Gardner, PhD., $ 10,000 for one year (supervising PI: C. Kappen)

1995 -1997 "Analysis of Hox-b6 Function for Spinal Cord Development in Hox-b6 Deficient

Mice" (PI: C. Kappen) Basil O' Conner Starter Scholar Award, March of Dimes Birth Defect Foundation, $ 39,000/year for two years 1994 - 1997 "Analysis of Transgenic Mice Expressing the Precursor Protein of Alzheimer's

Disease β-Amyloid" (PI: C. Kappen) Arizona Disease Control Research Commission, $ 30,000/year for three years 1993 - 1994 "Establishment of Transgenic Mouse Lines to Investigate the Role of Basic

Fibroblast Growth Factor in Neuronal Degeneration" (PI: C. Kappen) The American Parkinson Disease Association, $ 25,000 for 1 year (Co-PI: M. Stachowiak, Barrows Neurological Institute, Phoenix, AZ) 1993 - 1994 "Role of bFGF in Central and Peripheral CA Cells in Transgenic Mice" National Parkinson's Foundation, $ 20,000 for 1 year (PI: C. Kappen) (Co-PI: M. Stachowiak, Barrows Neurological Institute, Phoenix, AZ) 1993 - 1994 "Mice Expressing the Precursor Protein of Alzheimer's Disease β-Amyloid" (PI: C.

Kappen) Mayo Clinic Alzheimer's Disease Center, NIH-AG08031-P3, $ 20,000 for 1 year Fellowships: 1995 - 1997 Basil O' Conner Starter Scholar Award, March of Dimes Birth Defects Foundation 1988 - 1990 Postdoctoral fellowship, German Research Society

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Claudia Kappen, Dr. rer. nat. Awards: 2010 James G. Wilson Publication Award for 2009 (annual award presented in

recognition of the best paper published in the journal Birth Defects Research) 2013 Finalist for the James G. Wilson Publication Award for 2012 Honors: 1995 Election into Sigma Xi 1995 - 2012 Associate Editor “Molecular Biology and Evolution” (see Editorial Boards) since 1998 Scientific Reviewer for National Science Foundation (see Scientific Review) 1998 - 2000 Associate Member, Mayo Cancer Center, Cell Regulation Program 2000 - 2007 Associate Director, Mouse Genome Engineering Facility, UNMC 2000 - 2007 Member, Center for Environmental Toxicology, UNMC 2001 - 2007 Member, UNMC Eppley Cancer Center, NCI designated Cancer Center, UNMC 2002 - 2007 Member, Nebraska Informatics Center for the Life Sciences, NICLS 2002 Internal Advisor, Program Project Grant, Bioengineering and Orthopedics

Research Consortium (M. Johnson/R. Recker), Creighton University, Omaha, NE since 2002 Service on NIH Study sections (see Scientific Review) 2004 Nomination for J. Gilmore Outstanding Investigator Award, College of Medicine,

University of Nebraska Medical Center 2004 Member, Advisory Committee for the "Biotech in Omaha Project" grant to the US

Department of Labor for recruitment and training for careers in Biotechnology 2007 Member, Search Committee for the Director of Munroe-Meyer Institute at

University of Nebraska Medical Center (relinquished upon moving institutions) since 2009 Member of the Editorial Board: "Reproductive Toxicology" (see Editorial Boards) 2010 - 2012 Election into "College of CSR Reviewers" by the CSR director Dr. A. Scarpa since 2011 Associate Editor "Reproductive Toxicology" (see Editorial Boards) 2011 Invitation to serve as Secretary of the Teratology Society - declined to maintain

focus on my research program 2012 Judge at BioArt, FASEB’s first-ever scientific image competition

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Claudia Kappen, Dr. rer. nat. Editorial Boards: Current activities: since 2007 Member Editorial Board: "The Open Genomics Journal" since 2009 Member Editorial Board: "Reproductive Toxicology" since 2011 Associate Editor: Journal “Reproductive Toxicology” since 2012 Member Editorial Board: "PLoS One" since 2012 Member Editorial Board of "ISRN Developmental Biology" since 2013 Member Editorial Board of "New Journal of Science" Past activities: 2011 - 2012 Guest Editor for Special Issue of Birth Defects Research A "Proceedings from the

7th International Conference on Neural Tube Defects" (with Anne Molloy) 1995 - 2012 Associate Editor: Journal "Molecular Biology and Evolution" (six 3-yr. terms) 2004 Editorial Advisory Board: Journal "Recent Research Updates in Genetics"

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Claudia Kappen, Dr. rer. nat. Scientific Review: Grant Reviewer: NIH, Center for Scientific Review Study sections Regular member: 2010 - 2012 Member of "College of CSR Reviewers"

2008 - 2012 DEV-2 Development and Stem Cells (3 times/year)

2002 - 2007 DBD Developmental Brain Disorders (3 times/year) Temporary (ad-hoc) member or chair: 2013 - October NIDDK K awards DDK-C Subcommittee study section 2013 - July NIBIB K awards review panel ZEB1 OSR-E (O1) S 2012 - November ZHD1 Chair: NICHD P01 Program Project Review 2012 - March ZRG1 EMNR-Q (50): Specialized Centers of Research (SCOR) on Sex Differences 2011 - April ZDK1 GRB-J O1: DP3 Type I Diabetes Impact Award Review

for NIDDK 2011 - April ZHD1 DSR-Y: NICHD Developmental Mechanisms of Human

Structural Birth Defects P01 Review 2010 - April ZRG1 BCMB-A: Biological Chemistry and Macromolecular

Biophysics, Transformative R01 Roadmap Review 2009 - June ZRG1 EMNR-C: Endocrinology, Metabolism, Nutrition and

Reproductive Sciences Integrated Review Group, ARRA Challenge Grants Panel 15

2009 - June DBD: Developmental Brain Disorders 2008 - June NDPR: Neurodifferentiation, Plasticity, and Regeneration 2006 - December ZHD1 MRG-C (JD): NICHD P01 Program Project Review 2006 - June DEV-2: Development and Aging 2006 - April ZNS1-SRB-W (20): Neuroscience Blueprint Interdisciplinary

Center Core Grants 2005 - March MOSS-2: Special Emphasis Panel: Musculoskeletal, Oral and

Skin Sciences: Member Conflict 2005 - February PN: Pregnancy and Neonatology 2004 - November BDCN-F: Special Emphasis Panel: Brain Disorders and

Clinical Neuroscience: Member Conflict 2004 - November BDCN-E: Special Emphasis Panel: Brain Disorders and

Clinical Neuroscience: Member Conflict 2004 - July ZRR-BT-B: Special Emphasis Panel: NIH Roadmap

Exploratory Centers for Interdisciplinary Research 2004 - June DEV-1: Development: Member Conflict/Lack of Quorum 2003 - December CNNT: Special Emphasis Panel: Clinical Neuroplasticity and

Neurotransmitters Study Section: Member Conflict 2002 - November OBM-2: Oral Biology and Medicine

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Claudia Kappen, Dr. rer. nat. Scientific Review (continued): Grant Reviewer (continued): Other Grant Review Panels: since 1998 National Science Foundation, Integrative Biology since 2011 Israel Science Foundation 2013 - January National Science Foundation Graduate Research Fellowships Program Evaluation Meeting Molecular & Developmental Biology 2009 - March Environmental Protection Agency EPA STAR grant review 2007 - 2010 Pennington Biomedical Research Center Faculty pre-submission review of R01s, R21s 2007 Aircast Foundation, Guest Reviewer 2003 - 2007 Phillip Morris External Research Program 2005 Netherlands Organisation for Scientific Research (NWO) 2000 - 2007 University of Nebraska Research Initiative 2000 - 2007 University of Nebraska Medical Center Faculty R01 pre-submission review Dean's Indirect Cost Return awards Graduate fellowships Edda Itner Pediatric Grants 2000 - 2002 American Heart Association, Molecular Genetics 1997 - 2000 Medical Research Council, Hong Kong 1998 Alzheimer's Association 1995 - 1999 Mayo Foundation Cancer Center Pilot Grants 1994 - 1997 Mayo Clinic Scottsdale Category I Protected Research Time for Clinicians

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Claudia Kappen, Dr. rer. nat. Manuscript Reviewer for: American Journal of Respiratory Cell and Molecular Biology American Journal of Hematology American Journal of Human Genetics American Journal of Pathology American Journal of Physiology - Endocrinology and Metabolism Biochimica Biophysica Acta Biology of Reproduction Birth Defects Research BMC Developmental Biology Bone Brain Research Cytotherapy Developmental Biology Diabetes Diabetologia Encyclopedia of Molecular Biology and Biotechnology FASEB Journal FEBS Letters and FEBS OpenBio Gene Genetics Genomics Human Reproduction IEEE Hawaii International Conference on Systems Sciences International Journal of Obesity International Journal of Women's Health IPSI Conference 2004 (Integrated Publication Information Systems) Journal of Biological Chemistry Journal of Bone and Mineral Research Journal of Experimental Zoology Journal of Diabetes and its Complications Journal of Gastrointestinal Surgery Journal of Histochemistry and Cytochemistry Journal of Neuroscience Laboratory Investigation Neural Plasticity New York Academy of Sciences Mechanisms of Development Molecular Biology and Evolution Molecular Carcinogenesis Oncogene Osteoarthritis and Cartilage Physiology and Behavior PLoS One Proceedings of the National Academy of Sciences USA Reproductive Toxicology Reproductive Sciences The Anatomical Record The Open Genetics Journal Transgenic Research

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Claudia Kappen, Dr. rer. nat. Supervision of Personnel: Junior Faculty: Institution, Degree received: Current Position: 2009 - 2010 Nancy Arbour Delahaye, Ph.D. Louisiana State University

Homemaker, Plaquemine, LA

2007 - 2009

Claudia Kruger, Ph.D. University of Halle, Germany '98 Research Associate, Pennington Biomedical Research Center/LSU, Baton Rouge, LA

2005 - 2007 Gabriela Pavlinkova, Ph.D Charles University Prague, Czech Republic '99 Head, Laboratory of Molecular Pathogenetics, Institute of Biotechnology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

Postdoctoral Fellows: 1986 - 1987 Dr. med. Angela Gause Clinical Professor for Rheumatology, Lübeck

Medical University, Lübeck, and in private practice as an internist, Hamburg, Germany

1993 - 1996 David P. Gardner, Ph.D. University of Arizona '93 Professor (with tenure), Biomedical Sciences, AT Still University, School of Osteopathic Medicine, Mesa, AZ

1994 - 1996 MiMi Macias, Ph.D. University of Iowa '94 Research Program Manager, EAR Foundation of Arizona, Phoenix, AZ

1994 - 1997 Gloria Yueh, Ph.D.

University of Connecticut '94 Professor and Chairman of Biochemistry (with tenure), Midwestern University, Glendale, AZ

1996 - 1997 David Zacharias, Ph.D.

Mayo Graduate School '96 Assistant Professor, Whitney Laboratory, University of Florida, St. Augustine, FL

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Claudia Kappen, Dr. rer. nat. Supervision of Personnel (continued): Postdoctoral Fellows: Institution, Degree received: Current Position: 1996 - 1998 Charles Rundle, Ph.D. University of Alabama '96

Associate Research Professor, Loma Linda University Medical Center, Loma Linda, CA

1998 David J. Rickard, Ph.D. University of Pennsylvania Research Scientist, Musculoskeletal Disease, GlaxoSmithKline, King of Prussia, PA

1997 - 1999 Stephania Cormier, Ph.D. Lousiana State University Medical Center '79 Associate Professor (with tenure) of Pediatrics, Division of Infectious Disease, University of Tennessee Health Science, Center Le Bonheur Children’s Medical Center, Memphis, TN

2000 - 2002 Gary Leisman, Ph.D. Homemaker, Madison, WI

2000 - 2002 Maria A. Mello, M.D., Ph.D. Temple University '98

Visiting Research Fellow, NIAMS Intramural Research Program, Bethesda, MD

2002 Jörg Rahnenführer, Ph.D. University of Düsseldorf '99 Professor (with tenure), Statistical Methods in Genetics and Chemometrics, University of Dortmund, Germany

2001 - 2004 Tina Dinh (Treece), Ph.D. University of Florida '01 Bioinformatician, Agendia, Irvine, CA

2003 - 2005 Winfried-Paul Schuller, Ph.D. University of Tübingen '97 Clinical Research Associate, Novartis, Berlin, Germany

2005 - 2006 Suzan Kamel, Ph.D. Creighton University '04 Associate Professor, School of Biological Sciences, University of Missouri, Kansas City, MO

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Claudia Kappen, Dr. rer. nat. Supervision of Personnel (continued): Postdoctoral Fellows: Institution, Degree received: Current Position: 2003 - 2005 Aimee Limpach, Ph.D.

University of Nebraska '00 Associate Professor (with tenure), Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Creighton University, Omaha, NE

2003 - 2007 Claudia Kruger, Ph.D. University of Halle '98 Research Associate, Pennington Biomedical Research Center/LSU, Baton Rouge, LA

Graduate Students: Last known position: 1993 - 1998 Paul J. Yaworsky Scientist, Pfizer (formerly Wyeth-Ayerst

Research/Genetics Institute, Inc.), Boston, MA

Graduate Level Intern:

2013 - Nils Herion Louisiana State University '12

Rotation Students: Last known position: 1993 Monique Perdok Shonka Patent Attorney (Shareholder) with Schwegman,

Lundberg, Woessner, Minneapolis, MN

1994 Michael L. Garcia, PhD Associate Professor, Division of Biological Sciences, University of Missouri, Columbia, MO

1997 Stefanie Fisher (Daugherty), PhD Lecturer in Biology, UT Tyler, Tyler, TX

1999 William Sewell, PhD Postdoctoral Research Associate, Arizona State University, Tempe, AZ

2000 - 2001 Octavio Lie, MD Residency at Johns Hopkins University Medical Center, Baltimore, MD

2001 Chunhui Yi, PhD Postdoctoral Associate, School of Public Health, Yale University, New Haven, CT

2002 Anguraj Sadanandam, PhD Bioinformatician, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

2004 Dawn Eggert, PhD Southeast Poultry Research Laboratory, Agricultural Res. Service, USDA, Athens, GA

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Claudia Kappen, Dr. rer. nat. Supervision of Personnel (continued): Graduate Thesis Advisor: Mayo Graduate School: 1993 - 1998 Thesis Advisor: Paul J. Yaworsky Molecular Neuroscience Program 1994 - 1998 Thesis Committee: James Prescott Biochemistry and Molecular Biology 1994 - 1996 Thesis Committee: Valerie Hayes Molecular Neuroscience Program 1995 - 1996 Thesis Committee: Terri Sundtquist Biochemistry and Molecular Biology 1995/1996 Student Advisor: Sheri Holmen Biochemistry and Molecular Biology Undergraduate Students: Last known position: 1993 Rica Kimball, DVM (Carlton

College '95) Associate Veterinarian, Bent Tree Animal Hospital, Dallas, TX

1994 James Miner, MD (Mayo Medical School)

Associate Professor, Emergency Medicine, University of Minnesota, Minneapolis, MN

1994, '95, '96 Gerald J. Smith, MD (Harvard '96) Columbia University, New York, NY

1995 Seamus Lonergan, MD (Dartmouth '99)

Emergency Medicine, San Jose, CA

1995 Per Jambeck (Johns Hopkins '95) Bioengineering Program, UC San Diego, CA

1996 Siriana Kvalvik (Nair) (Wellesley '99)

US Embassy, Rabat, Morocco

1996 Mikala St.Jean (Kennedy) (UC Berkeley '97)

Los Angeles, CA

1997 Bethany Leggin (U of Arizona '98) Research Technologist University of Arizona, Tucson, AZ

1997 Nicole Johnston (Arizona State University '98)

University of Arizona Medical School, Tucson, AZ

1998 Berthold Wilden (University of Witten-Herdecke, 2000)

QA Manager, Grünenthal Inc., Aachen, Germany

1998 - 1999 Shernan Holtan, MD (Hastings Coll. '99)

Assistant Professor, Department of Medicine, Oregon Health Sciences University, Portland, OR

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Claudia Kappen, Dr. rer. nat. Supervision of Personnel (continued): Undergraduate Students (continued): 1998, 1999 Lauren Greenlee, PhD (University

of Michigan '01) Staff Scientist, National Institute of Standards and Technology, Boulder, CO

2001 John Eggers, MD PhD (St. Louis Univ. '03)

Resident, Orthopedic Surgery, School of Medicine, University of Missouri-Kansas City, Kansas City, MO

2002 Matthew Northam, PhD (University of Nebraska, Omaha '03)

Postdoctoral Fellow, Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE

2002 Allison Kaup, PhD (University of Nebraska Lincoln, '03)

Postdoctoral Fellow, Neuroscience, University of California San Francisco, CA

2002 Hope West, RN (Chadron State College, Chadron, NE, '04)

Tuba City Regional Health Care, Tuba City, AZ

2003 Jessica Ball (University of Northern Iowa '05)

current information unavailable

2003 Starlette Dossou (College of St. Mary, Omaha, NE, '05)

Biomedical Sciences Graduate Program, Creighton University, Omaha, NE

2005 Danielle Engle (Northwestern University '05)

Biomedical Graduate Program, UC San Diego, and Salk Institute San Diego, CA

2005 Chaeli Dougherty (Truman Sate University, Kirksville, MO, '09)

current information unavailable

2005 Katrin Montzka, Dr. rer. nat. Bioengineer, Urology, University Klinik Aachen, Aachen, Germany

2008 Tiffany Friedman (California State University, Fresno, CA, '09)

current information unavailable

2011 John Keller McKowen Lousiana State University, Baton Rouge, LA (’12)

2012 Carly Oetker Ouachita Baptist University, Arkadelphia, AR ('13)

Other: 2000 - 2007 Core facility managers and facility personnel 1994 - 2000, 2004 one high school student volunteer per school year (3-6 hours per week) since 1992 30 research technologists over 19 years since 1992 secretaries and research coordinators

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Claudia Kappen, Dr. rer. nat. Teaching: University of Essen: 1987 - 1988 "Gene technology and reproductive technologies" Mayo Graduate School: 1992 - 1999: Class: "Molecular Biology: Principals and Applications" Class: "Ethical Conduct in Research" Molecular Neuroscience Seminar Series (bi-weekly) Scottsdale Research Seminar Series (bi-weekly)

1992 - 1999: Molecular Neuroscience Journal Club (bi-weekly) Scottsdale Research Journal Club (bi-weekly) Seminar: "Homeobox Genes in Development" (weekly)

1993 - 1999: Scientific Enrichment Program for High School Students

1993 - 1999: Valley of the Sun (AZ) Biomedical Research Consortium

1993, 1994, 1996 Continuing Medical Education: "Molecular Biology and Human Disease: Applications in Clinical Medicine"; "Manipulation of the Mouse Genome: Application to Human Disease"

1998/1999 Class: "Developmental Biology" Mayo Graduate School Core Curriculum

University of Nebraska Medical Center: 2000 - 2007: Seminar: "Gene Regulation in Development" (weekly)

2000 - 2003 CHMG Research Seminar Series (monthly)

2001: Seminar: "Bioinformatics approaches" (monthly)

2001 - 2003: Class: “Ethical Conduct in Research”

2002: Class: “Molecular Basis of Human Disease”

2003 - 2007: BRTP-823: "Molecular Cell Biology"

2005 - 2007: BRTP-824: "Cell Signaling"

2005: Class: “Molecular Basis of Human Disease”

Pennington Biomedical Research Center / Louisiana State University: 2007, 2009, 2011, 2013: HUEC 7004: "Molecular and Clinical Nutrition I"

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Claudia Kappen, Dr. rer. nat. Institutional Committees: Mayo Clinic/Foundation: 1993 - 1996 Radiation Safety Committee, Mayo Clinic Scottsdale 1993 - 1996 Equal Opportunity and Diversity Committee, Mayo Clinic Scottsdale 1994 - 1999 Department of Biochemistry and Molecular Biology, Seminar Committee 1994 - 1998 Various Faculty Search Committees 1995 - 1999 System Communications Committee, Video Systems Management 1994 - 2000 Molecular Neuroscience Ph.D. Program, Education Committee University of Nebraska Medical Center: 2000 Center of Excellence Planning Committee, Animal Facilities Subcommittee 2000 Molecular Genomics Core Facility Planning Committee 2000 - 2003 Chair, Graduate Program Committee, Center for Human Molecular Genetics 2001 - 2002 Chair, DNA Microarray Core Facility Oversight Committee 2001 - 2004 Nebraska Informatics Center for the Life Sciences, Education Committee 2001 - 2004 Animal Facilities Oversight Committee 2003 Search Committee for Chair of the Dept. of Genetics, Cell Biology and Anatomy 2003 - 2007 Leadership Council for the Department of Genetics, Cell Biology and Anatomy 2004 - 2007: Council of Postdoctoral Education 2004 - 2007: Education Committee, Department of Genetics, Cell Biology and Anatomy 2004 - 2007: Chair, Department Research Infrastructure Committee 2004 - 2007: Research and Development Committee, College of Medicine 2004 - 2007: DNA Sequencing/Genotyping Core Facility Committee 2005 - 2007: Chair, Departmental grant pre-submission review committee

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Claudia Kappen, Dr. rer. nat. Institutional Committees (continued): Pennington Biomedical Research Center: 2007 - 2008 Mentoring Group Cell Biology and Signaling 2008 Chair, Mentoring Review Committee 2007 - 2010 Genetics Mentoring Group 2008 - 2010 Stem Cell and Developmental Biology Interest Group 2008 - 2011 Faculty Recruitment Committee 2008 - 2011 Promotion and Tenure Review Committee since 2009 T32 "Obesity - Genes to Man" Internal Advisory Committee since 2012 Pediatrics Interest Group since 2012 Institutional Biosafety Committee

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Claudia Kappen, Dr. rer. nat. Societies: American Society for Biochemistry and Molecular Biology (1994 - 2004) Society for Neuroscience (1994 - 2006) Society for Developmental Biology (USA) (since 1992) Society for Developmental Biology (Germany) (since 1992) Deutscher Hochschulverband (German Association of University Professors) (since 1993) Society for Molecular Biology and Evolution (1996 - 2012) Member of nominating committee for President-Elect, 2x Teratology Society (since 2004) Member of Elections and Nominations Committee (2008) Member of Strategic Planning Committee (2008) Member of Program Committee (2009) Member of Science Committee (2009 - 2011) Representative of the Teratology Society to FASEB (2009 - 2012) Member of F. Clark Fraser and Service Award Committee (2013/14) Obesity Society (2008 - 2010) International Federation of Placenta Associations (2008 - 2010) FASEB (Federarion of American Societies for Experimental Biology) (2009 - 2012) Member of The FASEB Science Policy Committee, delegate from the Teratology Society Genetics Society of America (since 2012) Extrainstitutional Activities: 2000 Selected by the President of the University of Nebraska to represent

Nebraska at "Science Coalition", the National Association of Research Universities for the promotion of Basic Science

Meetings with the Nebraska Congressional Delegation, Washington, D.C.

to represent innovative research projects and to lobby for federal funding during 2001 federal budget appropriations

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Claudia Kappen, Dr. rer. nat. Non-Scientific Educational Activities: 1991 - 1992 Instructor in Jewelry Making, Creative Arts Workshop, New Haven, CT Community Service (US only): 2002 - 2007 Member of the Board, Chris Lake Homeowners Association, re-elected 2005 Bellevue, NE (72 homeowners) 2004 - 2007 Member ex officio, Architecture Committee, Chris Lake Homeowners

Association, Bellevue, NE 2006 - 2007 Vice President, Chris Lake Homeowners Association, Bellevue, NE 2005 - 2007: Member of the Board of Trustees, Sanitary Improvement District 101,

Sarpy County, NE (375 property owners), elected with the highest number of votes among seven candidates

2005 - 2008 Member of the Board, Vista Montaña Homeowners Association, Fountain

Hills, AZ (16 homeowners) 2008 - 2009 Member, Lake Committee, Nicholson Lakes Homeowners Association,

Baton Rouge, LA (250+ homeowners) 2009 - 2012: Volunteer (tailgunner) at Cruise Moab, the largest annual event dedicated

to Toyota 4-wheel drive vehicles in the US since 2011: Member, Tonto Recreation Alliance, Arizona since 2011: Certified Volunteer of the US Forest Service, US Department of

Agriculture, Region 3 (New Mexico/Arizona), Tonto National Forest, Mesa Ranger District

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Claudia Kappen, Dr. rer. nat. Oral Presentations at National and International Meetings: 1989: FEBS Winter-School, "Developmental Biology", Maria-Alm, Austria 1990: First International Meeting on Preimplantation Genetics, Chicago, IL Inaugural Meeting of New England Molecular Evolutionary Biologists, Univ. of Connecticut, Storrs, CT 1993: First Annual Meeting, Society for Molecular Biology and Evolution, Irvine, CA 1994: World Congress "Computational Medicine, Public Health & Biotechnology", Austin, TX Workshop: Open Problems of Computational Molecular Biology, Telluride, CO Hoechst-Roussel Mayo Foundation Alliance Meeting, Jacksonville, FL 1995: National Association of Biology Teachers, Phoenix, AZ Third Annual Meeting, Society for Molecular Biology and Evolution, Hayama, Japan Workshop on Molecular Evolution of Development and Adaptive Characters (Sponsor: National Science Foundation, 12 participants from the USA), Japan 1997: NIH Workshop on "Skeletal Morphogenesis", Orlando, FL 1998: Western States Osteopathic Convention, Las Vegas, NV Gordon Conference "Bioengineering & Orthopedic Sciences", Proctor Academy, NH Cold Spring Harbor Workshop "Conditional Technologies in the Mouse", NY Fall Symposium, ASBMB "Regulation of Bone Growth", Taos, NM Session Chair: "Beyond the identification of transcribed sequences", Washington, DC

Platform presentation: "Beyond the identification of transcribed sequences", Washington, DC

EMBO Workshop "Skeletal Development", Munich, Germany 2000: Workshop "Sequence Analysis" at the Cold Spring Harbor meeting "Mouse Molecular Genetics", Cold Spring Harbor, NY 2001: Cologne Spring Meeting "Molecular Genetics", University of Cologne, Germany Society of Developmental Biology Midwest Meeting, Columbia, MO 41st Annual Meeting, Teratology Society, Montreal, Canada

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Claudia Kappen, Dr. rer. nat. Oral Presentations at National and International Meetings (continued): 2002: “2002 Recent Trends in Science and Technology”, American Lebanese University, Beirut, Lebanon Cold Spring Harbor Meeting “Evolution of Diversity”, Cold Spring Harbor, NY NIEHS Conference on Toxicogenomics, Research Triangle, Raleigh, NC Second International Neural Tube Defects Conference, Seabrook Island, SC Cold Spring Harbor Meeting "Mouse Molecular Genetics", Cold Spring Harbor, NY Mid-Atlantic Reproductive Toxicology Association, King of Prussia, PA 2003: 36th Hawaii International Conference on Systems Sciences, Bioinformatics track, Kona, HI Great Plains Society for Molecular Biology and Genetics, Omaha, NE 43rd Annual Midwest Developmental Biology Meeting, Kansas City, MO Session Moderator: Third International Neural Tube Defects Conference, Seabrook Island, SC Platform presentation: Third International Neural Tube Conference, Seabrook Island, SC 2004: Cold Spring Harbor Meeting “Evolution of Diversity”, Cold Spring Harbor, NY

Education Course on Embryonic Development, 1-hour lecture on Patterning, Teratology Society, 44th Annual Meeting, Vancouver, Canada

Platform presentation, 44th Annual Meeting, Teratology Society, Vancouver, Canada 2005: Cold Spring Harbor Meeting “The Biology of Genomes”, Cold Spring Harbor, NY Platform presentation, 45th Annual Meeting, Teratology Society, St. Pete's Beach, FL Session Moderator: Fourth International Neural Tube Defects Conference, Indian Wells, CA 2006: Session Co-Chair, 46th Annual meeting, Teratology Society, Tucson, AZ Platform presentation FASEB summer research conference "Folic Acid, Vitamin B12 &

One Carbon Metabolism", Indian Wells, CA 2007: Platform presentation, 47th Annual Meeting, Teratology Society, Pittsburgh, PA

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Claudia Kappen, Dr. rer. nat. Oral Presentations at National and International Meetings (continued): 2007: Platform presentation: Fifth International Neural Tube Defects Conference, Monterey, CA 2008: Platform presentation, 48th Annual Meeting Teratology Society, Monterey, CA 2009: Platform presentation, 49th Annual Meeting Teratology Society, Rio Grande, PR Session Co-Chair, 49th Annual meeting, Teratology Society, Rio Grande, PR Platform Presentation, Sixth International Neural Tube Defects Conference, Burlington, VT Session Moderator: Sixth International Neural Tube Defects Conference, Burlington, VT. 2010: Platform presentation, 50th Annual Meeting Teratology Society, Louisville, KY 2011: Platform Presentation, 51st Annual Meeting Teratology Society, San Diego, CA. Platform presentation: Seventh International Neural Tube Defects Conference, Austin, TX. Session Moderator: Seventh International Neural Tube Defects Conference, Austin, TX. 2012: Platform presentation, 52nd Annual Meeting Teratology Society, Baltimore, MD. 2013: Platform presentation, 53rd Annual Meeting Teratology Society, Tucson, AZ.

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Claudia Kappen, Dr. rer. nat. Invited Seminars: 1988: Max-Planck-Institute, Göttingen, Federal Republic of Germany University of Cologne, Institute for Genetics, Federal Republic of Germany 1990: Cornell University, J. Baker Institute of Animal Health, Veterinary School, Ithaca, NY 1991: University of Hamburg, Institute for Neurochemie and Zellbiologie, Germany Albert-Einstein, Yeshiva University, Department of Molecular Genetics, Bronx, NY New York University Medical Center, Department of Cell Biology, New York, NY University of Alabama, Neuroscience Center, Birmingham, AL 1991: Cedars-Sinai Medical Center, Transplantation Unit, Beverly Hills, Los Angeles, CA Mayo Clinic/Foundation, Department of Biochemistry and Molecular Biology, MN 1992: Columbia University, Department of Obstetrics and Gynecology, New York, NY Arizona State University, Department of Zoology, Tempe, AZ ASU, Department of Biological, Chemical and Mechanical Engineering, Tempe, AZ 1994: Mayo Clinic Scottsdale, Department of Neurology, Scottsdale, AZ Hoechst-Roussel Mayo Alliance Meeting, Jacksonville, FL Mayo Clinic Scottsdale, Department of Neurology, Scottsdale, AZ 1995: Mayo Foundation, Summer Undergraduate Research Program University of Hong Kong, Institute of Molecular Biology, Hong Kong Mayo Foundation Research Society, Rochester, MN 1996: University of Arizona, Department of Genetics, Tucson, AZ Humboldt-University, Charité Hospital, Institute for Anatomy, Berlin, Germany University of Cologne, Institute for Genetics, Cologne, Germany 1997: Mayo Foundation, Interdepartmental Genetics Society, Rochester, MN Mayo Clinic Scottsdale, Grand Rounds Internal Medicine, Scottsdale, AZ 1998: Chandler-Gilbert Community College, Chandler, AZ

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Claudia Kappen, Dr. rer. nat. Invited Seminars (continued): 1998: Arizona State University, Department of Life Sciences, ASU-West, Glendale, AZ Midwestern University, Department of Biochemistry, Glendale, AZ University of Arizona, Department of Molecular and Cell Biology, Tucson, AZ Arizona State University, Molecular and Cell Biology Program, Tempe, AZ The Babraham Institute, Babraham, Cambridge, United Kingdom 1998: Arthritis Centre of Excellence, Toronto Western Hospital, The Toronto Hospital,

University of Toronto, Toronto, Canada 1999: University of Connecticut Health Center, Department of Genetics and Developmental

Biology, Farmington, CT Cleveland Clinic Foundation, Lerner Research Institute, Cleveland, OH University of South Carolina, Department of Biology, Columbia, SC Univ. of Indiana Medical School, Wells Pediatric Research Center, Indianapolis, IN Pennsylvania State University School of Medicine, Department of Biochemistry and

Molecular Biology, Hershey, PA 1999: Children's Hospital Research Institute, Univ. of Southern California, Los Angeles, CA SUNY at Buffalo, Department of Oral Health, School of Medicine, Buffalo, NY University of West Virginia Medical School, Dept. of Anatomy, Morgantown, WV University of Kentucky, Sanders-Brown Center for Aging, Lexington, KY Florida Atlantic University, Department of Biomedical Sciences, Boca Raton, FL University of Chicago, Department of Pediatrics, Kennedy Center, Chicago, IL Univ. of Southern California, Department of Cell and Neurobiology, Los Angeles, CA Stowers Institute for Biomedical Research, Kansas City, MO Hospital for Joint Diseases, New York University Medical Center, New York, NY University of Pittsburgh, School of Medicine, Dept. of Molecular Genetics and Biochemistry, Pttsburgh, PA University of Kentucky, Department of Anatomy and Neurobiology, Lexington, KY

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Claudia Kappen, Dr. rer. nat. Invited Seminars (continued): 1999: University of Nebraska Medical Center, Center for Human Molecular Genetics, Munroe-Meyer Institute, Omaha, NE University of Maryland, Dental School, Baltimore, MD 2000: University of Tübingen, Institute for Human Genetics, Tübingen, Germany University of Tübingen, University Eye Clinic, Tübingen, Germany 2001: GSF-Research Center for Health and Environment, Munich-Neuherberg, Germany University of Düsseldorf, Institute for Developmental and Molecular Biology of Animals,

Düsseldorf, Germany University of Nebraska Medical Center, Interdepartmental Neuroscience Program,

Omaha, NE University of Nebraska Medical Center, Diabetes Research Initiative, Omaha, NE 2002: University of Nebraska at Omaha, Department of Computer Science, Omaha, NE University of Nebraska Medical Center, Department of Genetics, Cell Biology and

Anatomy, Omaha, NE Medical University of South Carolina, Department of Medical Sciences, Charleston, SC University of Nebraska at Lincoln, Biochemistry Department, Lincoln, NE University of Nebraska, Graduate Student Biochemistry Club, Lincoln, NE Texas A&M University, Institute for Biosciences and Technology, Houston, TX 2003: University of Nebraska Medical Center, Department of Genetics, Cell Biology and Anatomy, Omaha, NE University of Arkansas for Medical Sciences, Little Rock, AR CIIT Centers for Health Research, Research Triangle Park, NC University of Nebraska Medical Center, Division of Endocrinology, Department of

Internal Medicine, Omaha, NE 2005: State University of New York, Department of Biological Sciences, Albany, NY

University of Nebraska Medical Center, Department of Genetics, Cell Biology and Anatomy, Omaha, NE

McLaughlin Research Institute, Great Falls, MT

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Claudia Kappen, Dr. rer. nat. Invited Seminars (continued): 2005: Genome Department, Lawrence Berkeley National Laboratory, Berkeley, CA Pennington Biomedical Research Center, Baton Rouge, LA Baylor College of Dentistry, Dallas, TX Texas A&M University, Institute for Biosciences and Technology, Houston, TX 2006: Pennington Biomedical Research Center, Baton Rouge, LA University of Michigan, Department of Human Genetics, Ann Arbor, MI 2007: Pennington Biomedical Research Center, Baton Rouge, LA 2008: Pennington Biomedical Research Center, Baton Rouge, LA 2009: Universität Düsseldorf, Institute for Environmental Medical Research, Department of Molecular Immunology, Düsseldorf, Germany 2009: Louisiana State University Health Sciences Center, School of Medicine, Department of Pharmacology & Experimental Therapeutics, New Orleans, LA 2010: Pennington Biomedical Research Center, Baton Rouge, LA 2011: University of South Carolina, School of Medicine, Department of Pathology, Microbiology and Immunology, Columbia, SC 2011: Pennington Biomedical Research Center, Baton Rouge, LA Numerous presentations to lay groups, visitors, student groups and at fund raising occasions Radio, TV and print media interviews

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Claudia Kappen, Dr. rer. nat. Publications: Theses: 1. C. Kappen (1982).

Investigations on the localization of idiotypic determinants on variable regions of antibodies. Master's Thesis, University of Cologne, Germany.

2. C. Kappen (1987). Investigations on the cellular basis of B cell memory in the mouse. Ph.D. Dissertation. University of Cologne, Federal Republic of Germany. Manuscripts: * Trainees in my laboratory (Research Fellows and Graduate Students) 1. A. Radbruch, C. Zaiss, C. Kappen, M. Brüggemann, K. Beyreuther and K. Rajewsky (1985). Drastic change in idiotypic but not antigen-binding specificity of an antibody by a

single amino-acid substitution. Nature, 315, 506-508. PMID: 2582273 2. A. Gause, N. Yoshida, C. Kappen and K. Rajewsky (1987). In vivo generation and function of B cells in the presence of monoclonal anti-IgM

antibody: Implications for B cell tolerance. Eur. J. Immunol., 17, 981-990. PMID: 3497044 3. G. Lehle, C. Kolb, C. Kappen, R. Schüppel, E. Weiler and U. Krawinkel (1988). A map of VH genes next to the DH region in the Igh locus of two congenic Igh

recombinant mouse strains. Eur. J. Immunol., 18, 1275-1281. PMID: 2458265 4. T. Blankenstein, G. Lehle, R. Schüppel, C. Kolb, C. Kappen, E. Weiler and U. Krawinkel (1988). Content and organization of the immunoglobulin heavy chain variable region

gene locus in the mouse. In: Molecular Basis of the Immune Response. Ann. NY Acad. Sci., 546, 192-194. 5. K. Schughart, C. Kappen and F.H. Ruddle (1988). Mammalian homeobox-containing genes: genome organization, structure, expression and evolution. Br. J. Cancer Suppl., IX, 9-13. PMID: 2908191

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Claudia Kappen, Dr. rer. nat. Publications (continued): 6. C. Kappen, K. Schughart and F.H. Ruddle (1989). Organization and Expression of Homeobox Genes in Mouse and Man. in: Viral Oncogenesis and Cell Differentiation. Ann. NY Acad. Sci., 567, 243-252. PMID: 2572195 7. C. Kappen, K. Schughart and F.H. Ruddle (1989). Two steps in the evolution of Antennapedia-class vertebrate homeobox genes. Proc. Natl. Acad. Sci. USA, 86, 5459-5463. PMID: 2568634 8. K. Schughart, C. Kappen and F.H. Ruddle (1989). Duplication of large genomic regions during the evolution of vertebrate

homeobox genes. Proc. Natl. Acad. Sci. USA, 86, 7067-7071. PMID: 2571149 9. C. Kappen, K. Schughart and F.H. Ruddle (1989). Mammalian Antennapedia Class Homeobox Genes: Organization, Expression,

and Evolution. in: Molecular Genetics of Early Drosophila and Mouse Development, M.R.

Capecchi (Ed.) Cold Spring Harbor Laboratory Press, pp. 67-76. 10. G.W. Byrne, C. Kappen, M. Schughart, M. Utset, L. Bogarad and F.H. Ruddle (1991). Analysis of controller genes using the transgenic mouse system. in: Transgenic Animals, N. First & F. Haseltine (Eds.) Biotechnology, 16, 135-152. PMID: 1672506 11. C. Kappen and F.H. Ruddle (1991). Evolutionary analysis of mammalian homeobox genes. In: Preimplantation Genetics. Y. Verlinsky & A. Kuliev (Eds.), Plenum Press, New

York, pp. 189-201. 12. C. Kappen, K. Schughart and F.H. Ruddle (1993). Early Evolutionary Origin of Major Homeodomain Sequence Classes. Genomics, 18, 54-70. PMID: 7903958 13. C. Kappen and F.H. Ruddle (1993). Evolution of a regulatory gene family: HOM/HOX genes. Current Opinion in Genetics and Development, 3, 931-938. PMID: 7906973

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Claudia Kappen, Dr. rer. nat. Publications (continued): 14. C. Kappen (1994). The Evolution of Homeobox Genes: Experimental and Theoretical Approaches. in: Proceedings of the First World Congress on Computational Medicine and Biology, M. Witten (Ed.), World Scientific Publishing Company, Vol. 1. Ser. Math. Biol. Med., 5, 211-233. 15. F.H. Ruddle, J.L. Bartels, K.L. Bentley, C. Kappen, M.T. Murtha and J.W. Pendleton (1994). Evolution of Hox genes. Ann. Rev. of Genetics, 28, 423-442. PMID: 7893134 16. F.H. Ruddle and C. Kappen (1995). Mammalian homeo box genes: evolutionary and regulatory aspects of a network

gene system. in: Origins of the Human Brain Series, J.-P. Changeux and J. Chavaillon (Eds.),

Oxford: Oxford University Press, pp. 137-151. 17. C. Kappen (1995). Ancient evolutionary Origin of Homeodomains: Studies on Yeasts, Plants and

Animals. in: Current Topics on Molecular Evolution, M. Nei and N. Takahata (Eds.),

Institute of Molecular Evolutionary Genetics, Pennsylvania State University, USA, and the Graduate School for Advanced Studies, Hayama, Japan, pp. 199-212.

18. C. Kappen (1996). Theoretical Approaches to Homeobox Gene Evolution. Computers and Chemistry, 20, 49-60. PMID: 8867841 19. *D.P. Gardner, G.W. Byrne, F.H. Ruddle and C. Kappen (1996). Spatial and temporal regulation of a LacZ reporter transgene in a binary

transgenic mouse system. Transgenic Research, 5, 37-48. PMID: 8589738 20. C. Kappen (1996). Hox Genes in the Lung. Am. J. Resp. Cell Mol. Biol., 15, 156-162. PMID: 8703471 21. *P.J. Yaworsky, *D.P. Gardner and C. Kappen (1997). Transgenic analyses reveal developmentally regulated neuron- and muscle-

specific regulatory elements in the mouse neurofilament light chain gene promoter.

J. Biol. Chem., 272, 25112-25120. PMID: 9312121

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Claudia Kappen, Dr. rer. nat. Publications (continued): 22. *D.P. Gardner and C. Kappen (1998). Two novel transgene insertions on the mouse Y chromosome. Transgenics, 2, 221-224. 23. C. Kappen (1998). Early and late functions of homeobox genes in development of the axial skeleton. in: Skeletal Growth and Development: Clinical Issues and Basic Science

Advances, M.G. Ehrlich, J.A. Buckwalter, L.J. Sandell, S.B. Trippel (Eds.), American Academy of Orthopedic Surgeons, pp. 147-162.

24. *C. Rundle, *M.P. Macias, *Y.G. Yueh, *D.P. Gardner and C. Kappen (1998). Transactivation of Hox gene expression in a VP16-dependent binary transgenic

mouse system. Biochimica Biophysica Acta, 1398, 164-178. PMID: 9689916 25. *Y.G. Yueh, *D.P. Gardner and C. Kappen (1998). Evidence for regulation of cartilage differentiation by homeobox gene Hoxc-8. Proc. Natl. Acad. Sci. USA, 95, 9956-9961. PMID: 9707582 26. *P.J. Yaworsky and C. Kappen (1999). Heterogeneity of CNS progenitor cells revealed by enhancers in the nestin gene. Developmental Biology, 205, 309-321. PMID: 9917366 27. *C.H. Rundle and C. Kappen (1999). Developmental expression of the mouse gene encoding tyrosine phosphatase

Prl-1. J. Exp. Zool., 283, 612-618. PMID: 10194868 28. C. Kappen (2000). The VP16-dependent binary system for inducible gene expression in transgenic

mice. In: Genetic manipulation of receptor expression and function, D. Accili (Ed.),

John Wiley & Sons, pp. 69-92. 29. *D. Zacharias and C. Kappen (1999). Developmental expression of the four murine Plasma Membrane Calcium

ATPase (PMCA) genes in the mouse. Biochimica Biophysica Acta, 1428, 397-405. PMID: 10434059

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Claudia Kappen, Dr. rer. nat. Publications (continued): 30. C. Kappen (2000). The homeodomain: an ancient evolutionary motif in animals and plants. Computers and Chemistry, 24, 95-103. PMID: 10642882 31. *Y.G. Yueh, *P.J. Yaworsky and C. Kappen (2000). The Herpes Virus transcriptional activator VP16 is detrimental to preimplantation

development in the mouse. Molecular Reproduction and Development, 55, 37-46. PMID: 10602272

32. *D.P. Gardner and C. Kappen (2000). Developmental characterization and genomic mapping of a LacZ transgene

expressed in the mouse apical ectodermal ridge. J. Exp. Zool., 287, 106-111. PMID: 10861557 33. C. Kappen (2000). Disruption of the homeobox gene Hoxb-6 results in increased numbers of early

erythroid progenitors. Am. J. Hematol., 65, 111-118. PMID: 10996827 34. J.M. Salbaum and C. Kappen (2000). Cloning and Expression of Nope, a new Mouse Gene of the Immunoglobulin

Superfamily related to Guidance Receptors. Genomics, 64, 15-23. PMID: 10708514 35. C. Kappen (2000). Analysis of a complete homeobox gene repertoire: implications for the evolution

of diversity. Proc. Natl. Acad. Sci. USA, 97, 4481-4486. PMID: 10781048 36. C. Kappen and J.M. Salbaum (2001). 09/15: Comparative genomics of a conserved chromosomal region associated

with a complex human phenotype. Genomics, 73, 171-178. PMID: 11318607 37. C. Kappen and *P.J. Yaworsky (2003). Mutation of a putative nuclear receptor binding site abolishes activity of the nestin

midbrain enhancer. Biochimica Biophysica Acta, 1625, 109-115. PMID: 12527431

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Claudia Kappen, Dr. rer. nat. Publications (continued): 38. *L. Muller, *Y.G. Yueh, *P.J. Yaworsky, J.M. Salbaum and C. Kappen (2003). Caudal dysgenesis in Isl-1 transgenic mice. FASEB J., 17, 1349-1351. Epub 2003 May 08. PMID: 12738808 39. C. Kappen and J. M. Salbaum (2003). Comparative Genome Annotation for Mapping, Prediction and Discovery of

Genes. in: IEEE Proceedings of the 36th International Conference on System Sciences,

reviewed and refereed paper STCBICO1. 40. *S. Cormier, *M.A. Mello and C. Kappen (2003). Normal proliferation and differentiation of Hoxc-8 transgenic chondrocytes in

vitro. BMC Developmental Biology, 3, 4. PMID: 12713673 41. C. Kappen, *M.A. Mello, R.H. Finnell and J.M. Salbaum (2004). Folate modulates Hox gene controlled skeletal phenotypes. Genesis, 39, 155-166. PMID: 15282741 42. C. Kappen (2005). Homeobox gene repertoires: Implications for the evolution of diversity. in: Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics, L. Jorde

(Ed.), Wiley and Sons. 43. D.W.L. Ma, R.H. Finnell, L.A. Davidson, E.S. Callaway, O. Spiegelstein, J.A. Piedrahita,

J.M. Salbaum, C. Kappen, B. Weeks, J. James, D. Bozinov, J.R. Lupton and R.S. Chapkin (2005).

Folate Transport Gene Ablation in Mice Increases Sensitivity to Colon Carcinogenesis. Cancer Research, 65, 887-897 PMID: 15705887

44. O. Spiegelstein, A. Gould, B. Wlodarczyk, M. Tsie, X. Lu, C. Le, A. Troen, J. Selhub, J.A.

Piedrahita, J.M. Salbaum, C. Kappen, S. Melnyk, J. James, R.H. Finnell (2005). Developmental consequences of in utero arsenate exposure in mice with folate

transport deficiencies. Toxicol. Appl. Pharmacol., 203, 18-26. PMID: 15694460

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Claudia Kappen, Dr. rer. nat. Publications (continued): 45. J. Schug, *W.-P. Schuller, C. Kappen, J.M. Salbaum, M. Bucan and C.J. Stoeckert Jr.

(2005) Promoter Features Related to Tissue Specificity as Measured by Shannon Entropy. Genome Biology, 6, R33 Epub Mar 29, 2005.

PMID: 15833120 46. C. Kappen (2005). Folate supplementation in three genetic models: Implications for understanding

folate-dependent developmental pathways. Am. J. Med. Genet. C Sem. Med. Genet., 15, 24-30. PMID: 15800896 47. C. Kappen (2006). Birth Defects. in: The Encyclopedia of Human Development, N. J. Salkind (Ed.), SAGE

Publications. 48. *C. Kruger, C. Talmadge and C. Kappen (2006). Expression of folate pathway genes in the cartilage of Hoxd4 and Hoxc8

transgenic mice. Birth Defects Research A (formerly Teratology) Clin. Mol. Teratol., 76, 216-29. PMID: 16586448 49. C. Kappen, A. Neubüser, R. Balling and R.H. Finnell (2007). Molecular basis for skeletal variation: insights from developmental genetic

studies in mice. Birth Defects Research (Part B) Dev. Reprod. Toxicol. 80, 425-450. PMID: 18157899 50. *G. Pavlinkova, J.M. Salbaum and C. Kappen (2008). Wnt signaling in caudal dysgenesis and diabetic embryopathy. Birth Defects Res A Clin Mol Teratol. 82, 710-719. PMID: 18937363 51. *S. Kamel, C. Kruger, J.M. Salbaum and C. Kappen (2009). Morpholino-mediated knockdown in primary chondrocytes implicates Hoxc8 in

regulation of cell cycle progression. Bone, 44, 708-716. Epub Nov 21 2008 PMID: 19071237 52. J.M. Salbaum, R.H. Finnell and C. Kappen (2009). Regulation of folate receptor 1 gene expression in the visceral endoderm. Birth Defects Res A Clin Mol Teratol. 85, 303-313. Epub Jan 29, 2009 PMID: 19180647 This manuscript received the James G. Wilson Publication Award for 2009 (annual award presented for the best paper published in the journal Birth Defects Research)

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Claudia Kappen, Dr. rer. nat. Publications (continued): 53. C. Kappen and J.M. Salbaum (2009). Identification of gene regulatory elements in the Islet-1 gene locus. Int. J. Dev. Biol., 53, 935-46. PMID: 19598113 54. *G. Pavlinkova, J.M. Salbaum and C. Kappen (2009) Maternal diabetes alters transcriptional programs in the developing embryo. BMC Genomics, 10, 274. 2009 Epub Jun 18, 2009. PMID: 19538749 55. C. Kappen, *G. Pavlinkova, *C. Kruger and J.M. Salbaum (2010). Analysis of altered gene expression in diabetic embryopathy. in: Comprehensive Toxicology 2nd edition (C. McQueen, Ed. in Chief), Volume

12 Developmental Toxicology (T. Knudsen, Ed.). Elsevier. 56. *C. Kruger and C. Kappen (2010). Expression of cartilage developmental genes in Hoxc8- and Hoxd4-transgenic

mice. PLoS One, 5, e8978. PMID: 20126390 57. *C. Kruger and C. Kappen (2010). Microarray analysis of defective cartilage in Hoxc8- and Hoxd4-transgenic mice. Cartilage, 1: 217-232, first published on March 22, 2010 as doi:10.1177/1947603510363005 58. J.M. Salbaum and C. Kappen (2010). Neural tube defect genes and maternal diabetes during pregnancy. Birth Defects Res. A Clin. Mol. Teratol., 88, 601-611. PMID: 20564432 59. C. Kappen (2010). Vertebrate Hox genes and specializations in mammals. in: ''Key Innovations in Animal Evolution''. Rob DeSalle & B Schierwater (Eds.),

CRC Press, Science Publishers, Enfield, NH. 60. C. Kappen, *C. Kruger, J. MacGowan and J.M. Salbaum (2011). Maternal diet modulates the risk for neural tube defects in a mouse model of

diabetic pregnancy. Reprod. Toxicol., 31, 41-49. Epub 2010 Sep 22. PMID: 20868740

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Claudia Kappen, Dr. rer. nat. Publications (continued): 61. J.M. Salbaum, *C. Kruger, X. Zhang, *N. Arbour Delahaye, G. Pavlinkova, D.H. Burk and

C. Kappen (2011). Altered gene expression and spongiotrophoblast differentiation in placenta from a

mouse model of diabetic pregnancy Diabetologia, 54, 1909-1920. PMID: 21491160 62. J.M. Salbaum and C. Kappen (2011). Diabetic embryopathy: A role for the epigenome? Birth Defects Res. A Clin. Mol. Teratol., 91, 770-780. PMID: 21538816 63. J.M. Salbaum and C. Kappen (2012). Genetic and epigenomic footprints of folate. Prog. Mol. Biol. Transl. Sci., 108, 129-158. PMID: 22656376 64. C. Kappen, *C. Kruger, J. MacGowan, and J.M. Salbaum (2012). Maternal diet modulates placenta growth and gene expression in a mouse model

of diabetic pregnancy. PLoS One, 7, e38445. PMID: 22701643 65. J.M. Salbaum and C. Kappen (2012). Responses of the embryonic epigenome to maternal diabetes. Birth Defects Res. A Clin. Mol. Teratol., 94, 770-781. PMID: 22786762 This manuscript was a finalist for the James G. Wilson Publication Award for 2012 (annual award for the best paper published in the journal Birth Defects Research)

66. A.M. Molloy and C. Kappen (2012). Papers from the 7th International Neural Tube Defects Conference. Birth Defects Res. A Clin. Mol. Teratol., 94, 747-748. PMID: 23024064 [PubMed - as supplied by publisher] 67. C. Kappen, *P. Yaworksy, *Y.L. Muller and J.M. Salbaum (2013). Transgenic studies on the role of homeobox transcription factors in nervous

system development: Spina bifida in Isl-1 transgenic embryos. Transgenic Research, 22, 343-358Sep 30. [Epub ahead of print, Sept 30, 2012] PMID: 23054727 [PubMed - in process] doi: 10.1007/s11248-012-9643-x. 68. J.M. Salbaum, *C. Kruger and C. Kappen. Mutation at the folate receptor 4 locus modulates gene expression profiles in the

mouse uterus in response to preconceptional folate supplementation. Biochim Biophys Acta. 2013 May 4. doi:pii: S0925-4439(13)00152-X.10.1016/ j.bbadis.2013.04.028. [Epub ahead of print] PMID: 23651732 [PubMed - as supplied by publisher]

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Claudia Kappen, Dr. rer. nat. Publications (continued): Manuscripts submitted: 69. C. Kappen. Modeling anterior development in mice: diet as modulator of risk for neural tube

defects. Review for Special Issue "Craniofacial Development" of the American Journal of Medical Genetics, submitted

70. C. Kappen and J.M. Salbaum. Gene expression in teratogenic exposures: a new approach to understanding

individual risk. Reproductive Tonicology, submitted Abstracts: over 150 abstracts for scientific meetings and conferences

Publications in non-scientific press: C. Kappen: Research on DNA progresses in Omaha. Editorial on occasion of the National DNA Day and 50th Anniversary of the

Double Helix, Omaha World Herald, April 25, 2003 C. Kappen: Letter to the editor (concerning landscaping in a major city shopping area). Remscheider General-Anzeiger, 1973