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DUKE UNIVERSITY MEDICAL CENTER

CURRICULUM VITAE For Permanent Record

and the Appointments and Promotions Committee

DUKE UNIVERSITY MEDICAL CENTER CURRICULUM VITAE

Date Prepared: January 6, 2019 Name: Christopher Vine Plowe, MD, MPH, FASTMH Primary academic appointment: Department of Medicine Primary academic department: Infectious Diseases Secondary appointments: Global Health, Molecular Genetics and Microbiology Present academic rank and title (if any): Professor with tenure Date and rank of first Duke Faculty appointment: November 1, 2017 Instructor Temporary Medical Licensure: Maryland # D0048173 current through 9/30/19 Specialty certification(s) and dates: Diplomate, Internal Medicine, American Board of Internal Medicine 1989 - present Diplomate, Infectious Diseases, American Board of Internal Medicine 1996 - 2006 Certificate of Knowledge in Tropical Medicine and Travelers’ Health, 2000 - present American Society of Tropical Medicine & Hygiene Citizen of: United States of America Education: Institution Date Degree Cornell University, Ithaca, NY 1982 BA, Philosophy Cornell University, Ithaca, NY 1986 MD Columbia University School of Public Health, NY 1991 MPH, Tropical Medicine Professional training and academic career: Institution Position/Title Dates St. Luke’s Hospital, Columbia College of Intern & Resident, Internal Medicine 1986-1989 Physicians & Surgeons Columbia University School International Fellows Program 1989-1990 of International & Public Affairs

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St. Luke’s\ Roosevelt Hospital Center Attending Physician, Emergency Department 1989-1990 St. Luke’s Hospital, Columbia College of Chief Resident, Internal Medicine 1990-1991 and Surgeons Laboratory of Malaria Research, NIAID, NIH Fellow, Malaria Research 1991-1994 Johns Hopkins School of Medicine Fellow, Infectious Diseases 1994-1995 University of Maryland School of Medicine Assistant Professor, Department of Medicine 1995-2000 University of Maryland School of Medicine Assistant Professor (secondary appointment) 1997-2000 Microbiology and Immunology University of Maryland School of Medicine Associate Professor, Medicine, Chief, 2000-2005 Malaria Section, Center for Vaccine Development/Division of Geographic Medicine, Department of Medicine University of Maryland School of Medicine Associate Professor (secondary appointment) 2000-2005 Epidemiology and Preventive Medicine, and Microbiology and Immunology University of Maryland School of Medicine Professor with tenure, Medicine, and Chief, 2005-2010 Malaria Section, Center for Vaccine Development/Division of Geographic Medicine, Department of Medicine University of Maryland School of Medicine Professor (secondary appointment), 2005-present Epidemiology and Public Health and Microbiology and Immunology Howard Hughes Medical Institute Investigator 2008-2016 University of Maryland School of Medicine Professor with tenure, Medicine, 2010-2015 Associate Director for Research Training,

and Leader, Malaria Group, Center for Vaccine Development/Division of Geographic Medicine,

Department of Medicine University of Maryland School of Medicine Professor, with tenure, Medicine 2015-2016 Founding Director, Institute for Global Health Director, Division of Malaria Research University of Maryland School of Medicine Frank M. Calia MD Professor of Medicine, and 2016-2017 Founding Director, Institute for Global Health Duke University Professor, with tenure, Medicine, Molecular 2018- Genetics & Microbiology, and Global Health Director, Duke Global Health Institute

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Publications: Refereed journals:

1. Friedman R, Shear M, von Bulow B, Sweeney J, Plowe C. Compliance and outcome of patients accompanied by relatives to evaluations. Hospital & Community Psychiatry 35(10):1037-1038, 1984.

2. Hoffman S, Moechtar M, Simanjuntak C, Punjabi N, Kumala S, Silasahi P, Sutopo B, Kuncoro Y, Soriano M, Plowe C, Paleologo F, Edman D, Laughlin L. Rehydration and maintenance therapy of cholera patients in Jakarta: Citrate based versus bicarbonate based oral rehydration salt solution. Journal of Infectious Diseases 152:1159 1165, 1985.

3. von Bulow B, Sweeney J, Shear M, Friedman R, Plowe C. Family satisfaction with psychiatric evaluations. Health & Social Work 12:290 295, 1987.

4. Hoffman S, Oster C, Plowe CV, Woollettt G, Beier J, Chulay J, Wirtz R, Hollingdale M, Mugambi M. Naturally acquired antibodies to sporozoites do not prevent malaria: Vaccine development implications. Science 237:639 642, 1987.

5. Vaidya A, Morrisey J, Plowe CV, Kaslow D, Wellems T. Unidirectional dominance of cytoplasmic inheritance in two genetic crosses of Plasmodium falciparum. Molecular and Cellular Biology 13:7349-7357, 1993.

6. Plowe CV, Djimde A, Bouare M, Doumbo OK, Wellems TE. Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: Polymerase chain reaction methods for surveillance in Africa. American Journal of Tropical Medicine & Hygiene 52:565-568, 1995.

7. Plowe CV, Djimde A, Wellems T, Kouriba B, Diop S, Doumbo OK. Community pyrimethamine use and prevalence of resistant Plasmodium falciparum genotypes in Mali: A model for deterring resistance. American Journal of Tropical Medicine & Hygiene 55:467-471, 1996.

8. Plowe CV, Cortese J, Djimde A, Nwanyanwu O, Watkins W, Winstanley P, Estrada-Franco J, Mollinedo R, Avila J, Cespedes J, Carter D, Doumbo OK. Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance. Journal of Infectious Diseases 176:1590-1596, 1997.

9. Watkins W, Mberu E, Winstanley P. The efficacy of antifolate antimalarial combinations in Africa: a predictive model Plowe CV based on pharmacodynamic and pharmacokinetic analyses. Parasitology Today 13:459-464, 1997.

10. Nzila-Mounda A, Mberu E, Sibley C, Plowe CV, Winstanley P, Watkins W. Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in dihydrofolate reductase. Antimicrobial Agents and Chemotherapy 42:164-169, 1998

11. Kublin J, Witzig R, Shankar A, Quintana Zurita J, Gilman R, Aramburu Guarda J, Cortese J, Plowe CV. Molecular assays for surveillance of antifolate-resistant malaria. Lancet 351:1629-1630, 1998.

12. Perry R, Plowe CV, Koumare B, Bougoudogo F, Kotloff K, Losonsky G, Wasserman S, Levine M. A single dose of live oral cholera vaccine CVD 103-HgR is safe and immunogenic in HIV-infected and non-infected adults in Mali. Bulletins of the World Health Organization 76:63-71, 1998.

13. Djimde A, Plowe CV, Diop S, Dicko A, Wellems TE, Doumbo OK. Use of antimalarial drugs in Mali: Policy v. Reality. American Journal of Tropical Medicine & Hygiene 59:376-379, 1998.

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14. Cortese J, Plowe CV. Antifolate resistance due to new and known Plasmodium falciparum dihydrofolate reductase mutations expressed in yeast. Molecular and Biochemical Parasitology 94:205-214, 1998.

15. Diourte Y, Djimde A, Doumbo OK, Sagara I, Coulibaly Y, Dicko A, Diallo M, Diakite M, Cortese J, Plowe CV. Pyrimethamine-sulfadoxine efficacy and selection for mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase in Mali. American Journal of Tropical Medicine & Hygiene 60:475-478, 1999.

16. Watkins W, Mberu E, Winstanley P, Plowe CV. More on the efficacy of antifolate antimalarial combinations in Africa (Comment). Parasitology Today 15:131-132, 1999.

17. Urdaneta L, Plowe C, Goldman I, Lal A. Point mutations in dihydrofolate reductase and dihydropteroate synthase genes of Plasmodium falciparum isolates from Venezuela. American Journal of Tropical Medicine & Hygiene 61:457-462, 1999.

18. Doumbo OK, Kayentao K, Djimde A, Cortese J, Diourte Y, Konare A, Kublin J, Plowe CV. Rapid selection of P. falciparum DHFR mutants in vivo by pyrimethamine prophylaxis. Journal of Infectious Diseases 182:993-996, 2000.

19. Agarwal A, Guindo A, Cissoko Y, Taylor J, Coulibaly D, Kone A, Kayentao K, Djimde A, Plowe CV, Doumbo OK, Wellems TE, Diallo D. Hemoglobin C associated with protection from severe malaria in the Dogon country of Mali, a West African population with a low prevalence of Hemoglobin S. Blood 96:2358-2363, 2000.

20. Vasconcelos K, Plowe CV, Fontes C, Kyle D, Wirth D, Pereira da Silva L, Zalis M. Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase of isolates from the Amazon region of Brazil. Memorias do Instituto Oswaldo Cruz 95:721-728, 2000.

21. Djimdé A, Doumbo OK, Cortese J, Kayentao K, Doumbo S, Diourté Y, Coulibaly D, Dicko A, Su X, Fidock D, Nomura T, Wellems TE, Plowe CV. A molecular marker for chloroquine resistant falciparum malaria. New England Journal of Medicine 344:257-263, 2001.

22. Salcedo E, Cortese J, Plowe CV, Sims P, Hyde J. A bifunctional dihydrofolate synthetase-folylpolyglutamate synthetase in Plasmodium falciparum identified by functional complementation in yeast and bacteria. Molecular and Biochemical Parasitology 112:239-252, 2001.

23. Plowe CV, Doumbo OK, Djimde A, Kayentao K, Diourte Y, Doumbo S, Coulibaly D, Thera M, Wellems TE, Diallo D. Chloroquine treatment of uncomplicated Plasmodium falciparum malaria in Mali: Parasitological resistance vs. therapeutic efficacy. American Journal of Tropical Medicine & Hygiene 64:242-246, 2001.

24. Djimde A, Doumbo OK, Steketee R, Plowe CV. Application of a molecular marker for surveillance of chloroquine-resistant falciparum malaria. Lancet 358:890-891, 2001.

25. Iyer J, Milhous W, Cortese J, Kublin J, Plowe CV. Plasmodium falciparum cross-resistance between trimethoprim and pyrimethamine. Lancet 358:1066-1067, 2001.

26. Kublin J, Dzinjalamala FK, Kamwendo D, Malkin E, Cortese J, Martino L, Mukadam R, Rogerson S, Lescano A, Molyneux M, Winstanley P, Chimpeni P, Taylor TE, Plowe CV. Molecular markers for treatment failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone for falciparum malaria and a model for practical application in Africa. Journal of Infectious Diseases 185:380-388, 2002.

27. Mendez F, Munoz A, Carrasquilla G, Jurado D, Arevalo-Herrera M, Cortese J, Plowe CV. Determinants of treatment response to sulfadoxine- pyrimethamine and subsequent transmission potential in falciparum malaria. American Journal of Epidemiology 156:230-238, 2002.

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28. Cortese J, Caraballo A, Contreras C, Plowe CV. Origin and dissemination of Plasmodium falciparum drug-resistance mutations in South America. Journal of Infectious Diseases 186:999-1006, 2002.

29. Sulo J, Chimpeni P, Hatcher J, Kublin J, Plowe CV, Molyneux M, Marsh K, Taylor T, Watkins W, Winstanley P. Randomised clinical trial of chlorproguanil-dapsone (LAPDAP) versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi. Lancet 360:1136-1143, 2002.

30. Contreras C, Cortese J, Caraballo A, Plowe CV. Genetics of drug-resistant falciparum malaria in the Venezuelan state of Bolivar. American Journal of Tropical Medicine & Hygiene 186:999-1006, 2002.

31. El Setouhy M, Agbenyega T, Anto F, Clerk C, Koram K, English M, Molyneux C, Peshu N, Juma R, Kumwenda N, Mfutso-Bengu J, Molyneux M, Taylor T, Diarra D, Maiga S, Sylla M, Youssouf D, Falade C, Gbadegesin S, Lie R, Mugusi F, Ngassapa D, Ecuru J, Talisuna A, Emanuel E, Grady C, Wendler D, Higgs E, Plowe C, Sugarman J. Fair benefits for research in developing countries. Science 298:2133-2134, 2002.

32. Rowe J, Diallo D, Baby M, Poudiougo B, Coulibaly D, Cockburn I, Middleton J, Lyke K, Plowe CV, Doumbo OK, Moulds J. Erythrocyte complement receptor one expression level does not correlate with a Hind III restriction fragment length polymorphism in Africans; implications for studies on malaria susceptibility. Genes and Immunity 3:497-500, 2002.

33. Coulibaly D, Diallo D, Thera M, Dicko A, Guindo A, Koné A, Cissoko Y, Coulibaly S, Djimdé A, Lyke K, Doumbo OK, Plowe CV. Impact of pre-season treatment on incidence of falciparum malaria and parasite density at a site for testing malaria vaccines in Bandiagara, Mali. American Journal of Tropical Medicine & Hygiene 67:604-610, 2002.

34. Kublin J, Cortese J, Njunju E, Mukadam R, Wirima J, Kazembe P, Djimdé A, Kouriba B, Taylor T, Plowe CV. Reemergence of chloroquine-sensitive Plasmodium falciparum malaria following cessation of chloroquine use in Malawi. Journal of Infectious Diseases 187:1870-1875, 2003.

35. Lyke KE, Diallo D, Dicko A, Kone A, Coulibaly D, Guindo A, Cissoko Y, Sangare L, Coulibaly S, Dakouo B, Taylor TE, Doumbo OK, Plowe CV. Association of intraleukocytic Plasmodium falciparum malaria pigment with disease severity, clinical manifestations and prognosis in severe malaria. American Journal of Tropical Medicine & Hygiene 69:253-259, 2003.

36. Djimdé A, Doumbo OK, Traore O, Guindo A, Kayentao K, Diourté Y, Niare-Doumbo S, Coulibaly D, Koné A, Cissoko Y, Tekete M, Fofana B, Dicko A, Diallo D, Wellems TE, Kwiatkowski D, Plowe CV. Clearance of drug-resistant parasites as a model for protective immunity in falciparum malaria. American Journal of Tropical Medicine & Hygiene 69:558-563, 2003.

37. Moulds J, Thomas B, Doumbo OK, Diallo D, Lyke KE, Plowe CV, Rowe J, Birmingham D. Identification of the Kna/Knb polymorphism and a method for Knops genotyping. Transfusion 44:164-169, 2004. PMCID: PMC2877259.

38. Plowe CV, Kublin J, Dzinjalamala FK, Kamwendo D, Mukadam R, Chimpeni P, Molyneux M, Taylor TE. Sustained sulfadoxine-pyrimethamine efficacy for uncomplicated falciparum malaria in Malawi after ten years as first line therapy. British Medical Journal 328:545-548, 2004.

39. Cao K, Moormann A, Lyke KE, Masaberg C, Sumba O, Doumbo OK, Koech D, Lancaster A, Nelson M, Meyer D, Single R, Hartzman R, Plowe CV, Kazura J, Mann D, Sztein M, Thomson G, Fernandez-Vina M. Differentiation between African populations is evidenced by the diversity of Alleles and Haplotypes of HLA class I Loci. Tissue Antigens 63:293-325, 2004.

40. Diallo D, Doumbo OK, Dicko A, Guindo A, Coulibaly D, Kayentao K, Djimde A, Thera M, Fairhurst R, Plowe CV, Wellems TE. A comparison of anemia in hemoglobin C and normal hemoglobin A children with Plasmodium falciparum malaria. Acta Tropica 90:295-299, 2004.

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41. Lyke KE, Dicko A, Kone A, Coulibaly D, Guindo A, Cissoko Y, Traoré K, Plowe CV, Doumbo O. Incidence of severe Plasmodium falciparum malaria as a primary endpoint for vaccine efficacy trials in Bandiagara, Mali. Vaccine 22:3169-3174, 2004.

42. Djimde A, Dolo A, Ouattara A, Diakite S, Plowe CV, Doumbo OK. Molecular diagnosis of resistance to antimalarial drugs during epidemics and in war zones. Journal of Infectious Diseases 190:853-855, 2004.

43. Lyke KE, Burges R, Cissoko Y, Sangare L, Dao M, Diarra I, Kone A, Harley R, Plowe CV, Doumbo OK, Sztein M. Serum levels of pro-inflammatory cytokines interleukin-1 beta, IL-6, IL-8, IL-10, Tumor necrosis factor-alpha and IL-12p70 in Malian children with severe Plasmodium falciparum malaria and uncomplicated malaria or healthy controls. Infection and Immunity 72:5630-5637, 2004. PMCID: PMC517593.

44. Dzinjalamala FK, Macheso A, Kublin J, Taylor TE, Barnes K, Molyneux M, Plowe CV, Smith P. Blood folate concentrations and in vivo sulfadoxine-pyrimethamine failure in Malawian children with uncomplicated malaria. American Journal of Tropical Medicine & Hygiene 72:267-272, 2005.

45. Diallo D, Doumbo OK, Plowe CV, Wellems TE, Emanuel E, Hurst S. Community permission for medical research in developing countries. Clinical Infectious Diseases 41:255-259, 2005.

46. van Oosterhout J, Laufer MK, Graham S, Thumba F, Perez M, Chimbiya N, Wilson L, Chagomerana M, Molyneux M, Zijlstra E, Taylor TE, Plowe CV. A community-based study of the incidence of trimethoprim-sulfamethoxazole-preventable infections in Malawian adults living with HIV. Journal of Acquired Immune Deficiency Syndrome 39:626-631, 2005.

47. Lyke KE, Burges R, Cissoko Y, Sangare L, Kone A, Fernandez-Vina M, Plowe CV, Doumbo O, Sztein M. HLA-A2 supertype-restricted cell-mediated immunity by peripheral blood mononuclear cells derived from Malian children with severe or uncomplicated Plasmodium falciparum malaria and healthy controls. Infection and Immunity 73:5799-5808, 2005. PMCID: PMC1231120.

48. Dzinjalamala F, Macheso A, Kublin J, Taylor TE, Barnes K Molyneux M, Plowe CV, Smith P. Association between the pharmacokinetics and in vivo therapeutic efficacy of sulfadoxine-pyrimethamine in Malawian children. Antimicrobial Agents and Chemotherapy 49:3601-3606, 2005. PMCID: PMC1195435.

49. Thera M, Sehdev P, Coulibaly D, Traore K, Garba M, Cissoko Y, Kone A, Guindo A, Dicko A, Beavogui A, Djimde A, Lyke KE, Diallo D, Doumbo OK, Plowe CV. Impact of trimethoprim-sulfamethoxazole prophylaxis on falciparum malaria infection and disease. Journal of Infectious Diseases 192:1823-1829, 2005. PMCID: PMC2740817.

50. Lyke KE, Dicko A, Dabo A, Sangare L, Kone A, Coulibaly D, Guindo A, Traore K, Daou M, Diarra I, Sztein M, Plowe CV, Doumbo OK. Association of Schistosoma haematobium infection with protection against acute Plasmodium falciparum malaria in Malian children. American Journal of Tropical Medicine & Hygiene 73:1124-1130, 2005. PMCID: PMC2738948.

51. Laufer MK, van Oosterhout J, Thesing P, Thumba F, Zijlstra E, Graham S, Taylor T, Plowe CV. Impact of HIV-associated immunosuppression on malaria infection and disease in Malawi. Journal of Infectious Diseases 193:872-878, 2006.

52. Deans A, Lyke KE, Thera M, Plowe CV, Kone A, Doumbo OK, Kai O, Marsh K, Mackinnon M, Raza A, Rowe J. Low multiplication rates of African Plasmodium falciparum isolates and lack of association of multiplication rate and red blood cell selectivity with malaria virulence. American Journal of Tropical Medicine & Hygiene 74:554-563, 2006. PMCID: PMC2738946.

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53. Takala SL, Smith D, Stine O, Coulibaly D, Thera M, Doumbo O, Plowe CV. A high-throughput method for quantifying alleles and haplotypes of the malaria vaccine candidate Plasmodium falciparum merozoite surface protein-1 19kDa. Malaria Journal 5:31, 2006. PMCID: PMC1459863.

54. Laufer MK, van Oosterhout J, Perez M, Kanyanganlika J, Taylor TE, Plowe CV, Graham S. Observational cohort study of HIV-infected African children. Pediatric Infectious Diseases Journal 25:623-627, 2006.

55. Cissoko Y, Daou M, Lyke KE, Dicko A, Diarra I, Kone A, Guindo A, Traore K, Krishnegowda G, Diallo D, Doumbo OK, Plowe CV, Gowda D, Sztein M. Glycosylphosphatidylinositols (GPIs) in specimens derived from matched Malian children with severe or uncomplicated Plasmodium falciparum malaria and health controls. American Journal of Tropical Medicine & Hygiene 75:199-204, 2006.

56. Lyke KE, Dabo A, Sangare L, Arama C, Daou M, Diarra I, Plowe CV, Doumbo OK, Sztein M. Effects of concomitant Schistosoma haematobium infection on the serum cytokine levels elicited by acute Plasmodium falciparum malaria infection in Malian children. Infection and Immunity 74:5718-5724, 2006. PMCID: PMC1594876.

57. Kyriacou H, Stone G, Challis R, Raza A, Lyke KE, Thera MA, Kone A, Doumbo OK, Plowe CV, Rowe J. Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia. Molecular and Biochemical Parasitology 150:211-218, 2006. PMCID: PMC2176080.

58. Mendez F, Munoz A, Plowe CV. Use of area under the curve to characterize transmission potential after antimalarial treatment. American Journal of Tropical Medicine & Hygiene 75:640-644, 2006.

59. Laufer MK, Thesing PC, Eddington N, Masonga R, Dzinjalamala F, Takala SL, Taylor T, Plowe CV. Return of chloroquine anti-malaria efficacy in Malawi. New England Journal of Medicine 355:1959-1966, 2006.

60. Thera MA, Doumbo OK, Coulibaly D, Diallo D, Sagara I, Dicko A, Diemert D, Heppner Jr. DG, Stewart V, Angov E, Soisson L, Leach A, Tucker K, Lyke KE, Plowe CV and the Mali FMP1 Working Group. Randomized, double-blind controlled trial of the safety and allele-specific immunogenicity of the Plasmodium falciparum merozoite surface protein-142/AS02A malaria vaccine in Malian adults exposed to intense seasonal malaria. PLoS Clinical Trials 1:e34, 2006.

61. Rowe JA, Handel IG, Thera MA, Deans AM, Lyke KE, Kone A, Diallo DA, Raza A, Kai O, Marsh K, Plowe CV, Doumbo OK, Moulds JM. Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting. Proceedings of the National Academies of Science U S A 104:17471-17476, 2007. PMCID: PMC2077280.

62. van Oosterhout J, Laufer MK, Perez M, Graham S, Chimbiya N, Thesing PC, Alvarez-Martinez M, Wilson P, Chagomerana M, Zijlstra E, Taylor T, Plowe CV, Meshnick S. Pneumocystis pneumonia in HIV-positive adults, Malawi. Emerging Infectious Diseases 13:325-328, 2007. PMCID: PMC2725875.

63. Takala SL, Coulibaly D, Thera M, Dicko A, Smith D, Guindo A, Kone A, Ouattara A, Djimde A, Sehdev P. Lyke K, Diallo D, Doumbo OK, Plowe CV. Dynamics of polymorphism in a malaria vaccine antigen at a vaccine-testing site in Mali. PLoS Medicine 4:e93, 2007. PMCID: PMC1820605.

64. Djimde A, Kirkman L, Sassambara L, Diallo M, Plowe CV, Wellems TE, Doumbo OK. [In vitro cultivation of fields isolates of Plasmodium falciparum in Mali (in French)]. Bulletin Societe de Pathologie Exotique 100:3-5, 2007.

65. Takala SL, Smith D, Thera M, Coulibaly D, Doumbo OK, Plowe CV. Rare Plasmodium falciparum merozoite surface protein 1 19KDA (MSP119) haplotypes identified in Mali using high-throughput genotyping methods. American Journal of Tropical Medicine & Hygiene 76:855-859, 2007.

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66. Mendez F, Herrera S, Murrain B, Gutierrez A, Moreno LA, Manzano M, Munoz A, Plowe CV. Selection of antifolate-resistant Plasmodium falciparum by sulfadoxine-pyrimethamine treatment and infectivity to Anopheles mosquitoes. American Journal of Tropical Medicine & Hygiene 77:438-443, 2007.

67. Arman M, Raza A, Tempest LJ, Lyke KE, Thera MA, Kone A, Plowe CV, Doumbo OK, Rowe JA. Platelet-mediated clumping of Plasmodium falciparum infected erythrocytes is associated with high parasitemia but not severe clinical manifestations of malaria in African children. American Journal of Tropical Medicine & Hygiene 77:943-946, 2007. PMCID: PMC2696181.

68. Laufer MK, van Oosterhout JJ, Thesing PC, Dzinjalamala FK, Hsi T, Beraho L, Graham SM, Taylor TE, Plowe CV. Malaria treatment efficacy among people living with HIV: the role of host and parasite factors. American Journal of Tropical Medicine & Hygiene 77:627-632, 2007.

69. Takala SL, Ouattara A, Coulibaly D, Thera MA, Dicko A, Guindo A, Kone A, Traore K, Djimde A, Lyke KE, Diallo DA, Doumbo OK, Plowe CV. Dynamics of polymorphism in Plasmodium falciparum apical membrane antigen-1 over three years at a vaccine-testing site in Mali. American Journal of Tropical Medicine & Hygiene 77:14, 2007.

70. Lyke KE, Dabo A, Arama C, Daou M, Diarra I, Plowe CV, Doumbo OK, Sztein M. Effects of concomitant Schistosoma haematobium infection on the intracellular cytokine levels and T Cell memory populations elicited by acute Plasmodium falciparum malaria infection in Malian children. American Journal of Tropical Medicine & Hygiene 77:324, 2007.

71. Thera MA, Doumbo OK, Coulibaly D, Diallo DA, Kone AK, Guindo AB, Traore K, Dicko A, Sagara I, Sissoko MS, Baby M, Sissoko M, Diarra I, Niangaly A, Dolo A, Daou M, Diawara SI, Heppner DG, Stewart VA, Angov E, Bergmann-Leitner ES, Lanar DE, Dutta S, Soisson L, Diggs CL, Leach A, Owusu A, Dubois MC, Cohen J, Nixon JN, Gregson A, Takala SL, Lyke KE, Plowe CV. Safety and immunogenicity of an AMA-1 malaria vaccine in Malian adults: Results of a Phase 1 randomized controlled trial. PLoS One 3:e1465, 2008. PMCID: PMC2186380.

72. Bell DJ, Nyirongo SK, Mukaka M, Zijlstra EE, Plowe CV, Molyneux ME, Ward SA, Winstanley PA. Sulfadoxine-pyrimethamine-based combinations for malaria: a randomised blinded trial to compare efficacy, safety and selection of resistance in Malawi. PLoS One. 3:e1578, 2008. PMCID: PMC2229666.

73. Malaria Genomic Epidemiology Network. A global network for investigating the genomic epidemiology of malaria. Nature 456:732-737, 2008. PMCID: PMC3758999.

74. Lyke KE, Daou M, Diarra I, Kone A, Kouriba B, Thera MA, Dutta S, Lanar DE, Heppner DG Jr, Doumbo OK, Plowe CV, Sztein MB. Cell-mediated immunity elicited by the blood stage malaria vaccine apical membrane antigen 1 in Malian adults: Results of a Phase I randomized trial. Vaccine 27:2171-2176, 2009. PMCID: PMC2707027.

75. Jallow M, Teo YY, Small KS, Rockett KA, Deloukas P, Clark TG, Kivinen K, Bojang KA, Conway DJ, Pinder M, Sirugo G, Sisay-Joof F, Usen S, Auburn S, Bumpstead SJ, Campino S, Coffey A, Dunham A, Fry AE, Green A, Gwilliam R, Hunt SE, Inouye M, Jeffreys AE, Mendy A, Palotie A, Potter S, Ragoussis J, Rogers J, Rowlands K, Somaskantharajah E, Whittaker P, Widden C, Donnelly P, Howie B, Marchini J, Morris A, Sanjoaquin M, Achidi EA, Agbenyega T, Allen A, Amodu O, Corran P, Djimde A, Dolo A, Doumbo OK, Drakeley C, Dunstan S, Evans J, Farrar J, Fernando D, Hien TT, Horstmann RD, Ibrahim M, Karunaweera N, Kokwaro G, Koram KA, Lemnge M, Makani J, Marsh K, Michon P, Modiano D, Molyneux ME, Mueller I, Parker M, Peshu N, Plowe CV, Puijalon O, Reeder J, Reyburn H, Riley EM, Sakuntabhai A, Singhasivanon P, Sirima S, Tall A, Taylor TE, Thera M, Troye-Blomberg M, Williams TN, Wilson M, Kwiatkowski DP; Wellcome Trust Case Control Consortium; Malaria Genomic Epidemiology Network. Genome-wide and fine-resolution association analysis of malaria in West Africa. Nature Genetics 41:657-665, 2009. PMCID: PMC2889040.

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76. Takala SL, Coulibaly D, Thera MA, Batchelor AH, Cummings MP, Escalante AA, Ouattara A, Traore K, Niangaly A, Djimde AA, Doumbo OK, Plowe CV. Extreme polymorphism in a vaccine antigen and risk of clinical malaria: Implications for vaccine development. Science Translational Medicine 1:2ra5, 2009. PMCID: PMC2822345.

77. Coulibaly D, Rebaudet S, Travassos M, Tolo Y, Laurens M, Kone AK, Traore K, Guindo A, Diarra I, Niangaly A, Daou M, Dembele A, Sissoko M, Kouriba B, Dessay N, Gaudart J, Piarroux R, Thera MA, Plowe CV, Doumbo OK. Spatio-temporal analysis of malaria within a transmission season in Bandiagara, Mali. Malaria Journal 12:82 2013. PMCID: PMC3618208.

78. Doumbo O, Thera M, Koné A, Raza A, Tempest L, Lyke K, Plowe C, Rowe J. High levels of Plasmodium falciparum rosetting in all clinical forms of severe malaria in African children. American Journal of Tropical Medicine & Hygiene 81:987-993, 2009. PMCID: PMC2877664.

79. Thera MA, Doumbo OK, Coulibaly D, Laurens MB, Kone AK, Guindo AB, Traore K, Sissoko M, Diallo DA, Diarra I, Kouriba B, Daou M, Dolo A, Baby M, Sissoko MS, Sagara I, Niangaly A, Traore I, Olotu A, Godeaux O, Leach A, Dubois MC, Ballou WR, Cohen J, Thompson D, Dube T, Soisson L, Diggs CL, Takala SL, Lyke KE, House B, Lanar DE, Dutta S, Heppner DG, Plowe CV. Safety and immunogenicity of an AMA1 malaria vaccine in Malian children: Results of a phase 1 randomized controlled trial. PLoS One 5:e9041, 2010. PMCID: PMC2816207.

80. Beavogui AH, Djimde AA, Gregson A, Toure AM, Dao A, Coulibaly B, Ouologuem D, Fofana B, Sacko A, Tekete M, Kone A, Niare O, Wele M, Plowe CV, Picot S, Doumbo OK. Low infectivity of Plasmodium falciparum gametocytes to Anopheles gambiae following treatment with sulfadoxine-pyrimethamine in Mali. International Journal of Parasitology 40:1213-1320, 2010. PMCID: PMC3571761.

81. Ouattara A, Mu J, Takala-Harrison S, Saye R, Sagara I, Dicko A, Niangaly A, Duan J, Ellis RD, Miller LH, Su XZ, Plowe CV, Doumbo OK. Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine. Malaria Journal 9:175, 2010. PMCID: PMC2908102.

82. Laufer MK, Takala-Harrison S, Dzinjalamala FK, Stine OC, Taylor TE, Plowe CV. Return of chloroquine-susceptible falciparum malaria in Malawi was a reexpansion of diverse susceptible parasites. Journal of Infectious Diseases 202:801-808, 2010. PMCID: PMC3380613.

83. Lyke KE, Laurens MB, Adams M, Billingsley PF, Richman A, Loyevsky M, Chakravarty S, Plowe CV, Sim BK, Edelman R, Hoffman SL. Plasmodium falciparum malaria challenge by the bite of aseptic anopheles stephensi mosquitoes: Results of a randomized infectivity trial. PLoS One 5:e13490, 2010. PMCID: PMC2958836.

84. Lyke KE, Fernandez-Vina MA, Cao K, Hollenbach J, Coulibaly D, Kone AK, Guindo A, Burdett LA, Hartzman RJ, Wahl AR, Hildebrand WH, Doumbo OK, Plowe CV, Sztein MB. Association of HLA alleles with Plasmodium falciparum severity in Malian children. Tissue Antigens 77:562-571, 2011. PMCID: PMC3152196.

85. Epstein JE, Tewari K, Lyke KE, Sim BK, Billingsley PF, Laurens MB, Gunasekera A, Chakravarty S, James ER, Sedegah M, Richman A, Velmurugan S, Reyes S, Li M, Tucker K, Ahumada A, Ruben AJ, Li T, Stafford R, Eappen AG, Tamminga C, Bennett JW, Ockenhouse CF, Murphy JR, Komisar J, Thomas N, Loyevsky M, Birkett A, Plowe CV, Loucq C, Edelman R, Richie TL, Seder RA, Hoffman SL. Live attenuated malaria vaccine designed to protect through hepatic CD8+ T cell immunity. Science 334:475-480, 2011.

86. Thera MA, Doumbo OK, Coulibaly D, Laurens MB, Ouattara A, Kone AK, Guindo AB, Traore K, Traore I, Kouriba B, Diallo DA, Diarra I, Daou M, Dolo A, Tolo Y, Sissoko MS, Niangaly A, Sissoko M, Takala-Harrison S, Lyke KE, Wu Y, Blackwelder WC, Godeaux O, Vekemans J, Dubois MC, Ballou WR, Cohen J, Thompson D, Dube T, Soisson L, Diggs CL, House B, Lanar DE, Dutta S, Heppner

10

DG, Plowe, CV. A field trial to assess a blood-stage malaria vaccine. New England Journal of Medicine 365:1004-1013, 2011. PMCID: PMC3242358.

87. Mita T, Venkatesan M, Ohashi J, Culleton R, Takahashi N, Tsukahara T, Ndounga M, Dysoley L, Endo H, Hombhanje F, Ferreira MU, Plowe CV, Tanabe K. Limited geographical origin and global spread of sulfadoxine-resistant dhps alleles in Plasmodium falciparum populations. Journal of Infectious Diseases 201:1980-1988, 2011. PMCID: PMC3209816.

88. Venkatesan M, Amaratunga C, Campino S, Auburn S, Koch O, Lim P, Uk S, Socheat D, Kwiatkowski DP, Fairhurst RM, Plowe CV. Using CF11 cellulose columns to inexpensively and effectively remove human DNA from Plasmodium falciparum-infected whole blood samples. Malaria Journal 11:41, 2012. PMCID: PMC3295709.

89. Lyke KE, Dabo A, Arama C, Daou M, Diarra I, Wang A, Plowe CV, Doumbo OK, Sztein MB. Reduced T regulatory cell response during acute Plasmodium falciparum infection in Malian children co-infected with Schistosoma haematobium. PLoS One 7:e31647, 2012. PMCID: PMC3279404.

90. Gandhi K, Thera MA, Coulibaly D, Traoré K, Guindo AB, Doumbo OK, Takala-Harrison S, Plowe CV. Next generation sequencing to detect variation in the Plasmodium falciparum circumsporozoite protein. American Journal of Tropical Medicine & Hygiene 86:775-781, 2012. PMCID: PMC3335679.

91. Lyke KE, Wang A, Dabo A, Arama C, Daou M, Diarra I, Plowe CV, Doumbo OK, Sztein MB. Antigen-specific B memory cell responses to Plasmodium falciparum malaria antigens and Schistosoma haematobium antigens in co-infected Malian children. PLoS One. 7: e37868, 2012. PMCID: PMC3367916.

92. Shaukat AM, Gilliams EA, Kenefic LJ, Laurens MB, Dzinjalamala FK, Nyirenda OM, Thesing PC, Jacob CG, Molyneux ME, Taylor TE, Plowe CV, Laufer MK. Clinical manifestations of new versus recrudescent malaria infections following anti-malarial drug treatment. Malaria Journal 11:207, 2012. PMCID: PMC3489583.

93. Manske M, Miotto O, Campino S, Auburn S, Almagro-Garcia J, Maslen G, O'Brien J, Djimde A, Doumbo O, Zongo I, Ouedraogo JB, Michon P, Mueller I, Siba P, Nzila A, Borrmann S, Kiara SM, Marsh K, Jiang H, Su XZ, Amaratunga C, Fairhurst R, Socheat D, Nosten F, Imwong M, White NJ, Sanders M, Anastasi E, Alcock D, Drury E, Oyola S, Quail MA, Turner DJ, Ruano-Rubio V, Jyothi D, Amenga-Etego L, Hubbart C, Jeffreys A, Rowlands K, Sutherland C, Roper C, Mangano V, Modiano D, Tan JC, Ferdig MT, Amambua-Ngwa A, Conway DJ, Takala-Harrison S, Plowe CV, Rayner JC, Rockett KA, Clark TG, Newbold CI, Berriman M, MacInnis B, Kwiatkowski DP. Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing. Nature 487:375-379, 2012. PMCID: PMC3738909.

94. Maiga AW, Fofana B, Sagara I, Dembele D, Dara A, Traore OB, Toure S, Sanogo K, Dama S, Sidibe B, Kone A, Thera MA, Plowe CV, Doumbo OK, Djimde AA. No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in Mali. American Journal of Tropical Medicine & Hygiene 87:23-28, 2012. PMCID: PMC3391052.

95. Laufer MK, Thesing PC, Dzinjalamala FK, Nyirenda OM, Masonga R, Laurens MB, Stokes-Riner A, Taylor TE, Plowe CV. A longitudinal trial comparing chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria. PLoS One 7:e42284, 2012. PMCID: PMC3422316.

96. Ouattara A, Takala-Harrison S, Thera MA, Coulibaly D, Niangaly A, Saye R, Tolo Y, Dutta S, Heppner DG, Soisson L, Diggs CL, Vekemans J, Cohen J, Blackwelder WC, Dube T, Laurens MB, Doumbo OK, Plowe CV. Molecular basis of allele-specific efficacy of a blood-stage malaria vaccine: vaccine development implications. Journal of Infectious Diseases 207:511-519, 2013. PMCID: PMC3537449.

11

97. Takala-Harrison S, Clark TG, Jacob CG, Cummings MP, Miotto O, Dondorp AM, Fukuda MM, Nosten F, Noedl H, Imwong M, Bethell D, Se Y, Lon C, Tyner SD, Saunders DL, Socheat D, Ariey F, Phyo AP, Starzengruber P, Fuehrer HP, Swoboda P, Stepniewska K, Flegg J, Arze C, Cerqueira GC, Silva JC, Ricklefs SM, Porcella SF, Stephens RM, Adams M, Kenefic LJ, Campino S, Auburn S, Macinnis B, Kwiatkowski DP, Su XZ, White NJ, Ringwald P, Plowe CV. Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia. Proceedings of the National Academy of Sciences USA 110:240-245, 2013. PMCID: PMC3538248.

98. Coulibaly D, Rebaudet S, Travassos M, Tolo Y, Laurens M, Kone AK, Traore K, Guindo A, Diarra I, Niangaly A, Daou M, Dembele A, Sissoko M, Kouriba B, Dessay N, Gaudart J, Piarroux R, Thera MA, Plowe CV, Doumbo OK. Spatio-temporal analysis of malaria within a transmission season in Bandiagara, Mali. Malaria Journal 12:82 2013. PMID: PMC3618208.

99. Miotto O, Almagro-Garcia J, Manske M, Macinnis B, Campino S, Rockett KA, Amaratunga C, Lim P, Suon S, Sreng S, Anderson JM, Duong S, Nguon C, Chuor CM, Saunders D, Se Y, Lon C, Fukuda MM, Amenga-Etego L, Hodgson AV, Asoala V, Imwong M, Takala-Harrison S, Nosten F, Su XZ, Ringwald P, Ariey F, Dolecek C, Hien TT, Boni MF, Thai CQ, Amambua-Ngwa A, Conway DJ, Djimdé AA, Doumbo OK, Zongo I, Ouedraogo JB, Alcock D, Drury E, Auburn S, Koch O, Sanders M, Hubbart C, Maslen G, Ruano-Rubio V, Jyothi D, Miles A, O'Brien J, Gamble C, Oyola SO, Rayner JC, Newbold CI, Berriman M, Spencer CC, McVean G, Day NP, White NJ, Bethell D, Dondorp AM, Plowe CV, Fairhurst RM, Kwiatkowski DP. Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia. Nature Genetics 45:648-655, 2013. PMCID: PMC3807790.

100. Laurens MB, Billingsley P, Richman A, Eappen AG, Adams M, Li T, Chakravarty S, Gunasekera A, Jacob CG, Sim BK, Edelman R, Plowe CV, Hoffman SL, Lyke KE. Successful human infection with P. falciparum using three aseptic Anopheles stephensi Mosquitoes: A new model for Controlled Human Malaria Infection. PLoS One. 8:e68969, 2013. PMCID: PMC3712927.

101. Travassos MA, Niangaly A, Bailey JA, Ouattara A, Coulibaly Dk, Laurens MB, Pabnlo J, Jasinskas A, Nakajima-Sasaki R, Berry AA, Takala-Harrison S, Kouriba B, Rowe JA, Lyke KE, Doumbo OK, Thera MA, Felgner PL, Plowe CV. Seroreactivity to Plasmodium falciparum erythrocyte membrane protein 1 intracellular domain in malaria-exposed children and adults. Journal of Infectious Diseases 208:1514-1519, 2013. PMCID: PMC: 3789569.

102. Seder RA, Chang LJ, Enama ME, Zephir KL, Sarwar UN, Gordon IJ, Holman LA, James ER, Billingsley PF, Gunasekera A, Richman A, Chakravarty S, Manoj A, Velmurugan S, Li M, Ruben AJ, Li T, Eappen AG, Stafford RE, Plummer SH, Hendel CS, Novik L, Costner PJ, Mendoza FH, Saunders JG, Nason MC, Richardson JH, Murphy J, Davidson SA, Richie TL, Sedegah M, Sutamihardja A, Fahle GA, Lyke KE, Laurens MB, Roederer M, Tewari K, Epstein JE, Sim BK, Ledgerwood JE, Graham BS, Hoffman SL; VRC 312 Study Team. Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine. Science 341:6152, 2013.

103. Khattak AA, Venkatesan M, Nadeem MF, Satti HS, Yaqoob A, Strauss K, Khatoon L, Malik SA, Plowe CV. Prevalence and distribution of human Plasmodium infection in Pakistan. Malaria Journal 12:297, 2013. PMCID: PMC3765785.

104. Khattak AA, Venkatesan M, Jacob CG, Artimovich EM, Nadeem MF, Nighat F, Hombhanje F, Mita T, Malik SA, Plowe CV. A comprehensive survey of polymorphisms conferring anti-malarial resistance in Plasmodium falciparum across Pakistan. Malaria Journal 12:300, 2013. PMCID: PMC3765786.

105. Khattak AA, Venkatesan M, Khatoon L, Ouattara A, Kenefic LJ, Nadeem MF, Nighat F, Malik SA, Plowe CV. Prevalence and patterns of antifolate and chloroquine drug resistance markers in Plasmodium vivax across Pakistan. Malaria Journal 12:310, 2013. PMCID: PMC3766695.

106. Laurens MB, Thera MA, Coulibaly D, Ouattara A, Kone AK, Guindo AB, Traore K, Traore I, Kouriba B, Diallo DA, Diarra I, Daou M, Dolo A, Tolo Y, Sissoko MS, Niangaly A, Sissoko M, Takala-Harrison S,

12

Lyke KE, Wu Y, Blackwelder WC, Godeaux O, Vekemans J, Dubois MC, Ballou WR, Cohen J, Dube T, Soisson L, Diggs CL, House B, Bennett JW, Lanar DE, Dutta S, Heppner DG, Plowe CV, Doumbo OK. Extended safety, immunogenicity and efficacy of a blood-stage malaria vaccine in Malian children: 24-month follow-up of a randomized, double-blinded phase 2 trial. PLoS One 8:e79323, 2013. PMCID: PMC3832522.

107. Mita T, Ohashi J, Venkatesan M, Marma AS, Nakamura M, Plowe CV, Tanabe K. Ordered accumulation of mutations conferring resistance to sulfadoxine-pyrimethamine in the Plasmodium falciparum parasite. Journal of Infectious Diseases 209:130-139, 2014.

108. Kayentao K, Guirou EA, Doumbo OK, Venkatesan M, Plowe CV, Parsons TL, Hendrix CW, Nyunt MM. Preliminary study of quinine pharmacokinetics in pregnant women with malaria-HIV co-infection. American Journal of Tropical Medicine & Hygiene 90:530-534, 2014. PMCID: PMC3945700.

109. Gilliams EA, Jumare J, Claassen CW, Thesing PC, Nyirenda OM, Dzinjalamala FK, Taylor T, Plowe CV, Tracy LA, Laufer MK. Chloroquine-azithromycin combination antimalarial treatment decreases risk of respiratory and gastrointestinal tract infections in Malawian children. Journal of Infectious Diseases 210:585-592, 2014. PMCID: PMC4172042.

110. Frosch AE, Laufer MK, Mathanga DP, Takala-Harrison S, Skarbinski J, Claassen CW, Dzinjalamala FK, Plowe CV. Return of widespread chloroquine-sensitive Plasmodium falciparum to Malawi. Journal of Infectious Diseases 210:1110-1114, 2014.

111. Murphy SC, Hermsen CC, Douglas AD, Edwards NJ, Petersen I, Fahle GA, Adams M, Berry AA, Billman ZP, Gilbert SC, Laurens MB, Leroy O, Lyke KE, Plowe CV, Seilie AM, Strauss KA, Teelen K, Hill AV, Sauerwein RW. External quality assurance of malaria nucleic acid testing for clinical trials and eradication surveillance. PLoS One 9:e97398, 2014. PMCID: PMC4023973.

112. Gandhi K, Thera MA, Coulibaly D, Traoré K, Guindo AB, Ouattara A, Berry AA, Takala-Harrison S, Doumbo OK, Plowe CV. Variation in the circumsporozoite protein of Plasmodium falciparum: vaccine development implications: Genetic variation in a malaria vaccine antigen. PLOS One 9:e101783, 2014. PMCID: PMC4081809.

113. Ashley EA, Dhorda M, Fairhurst RM, Amaratunga C, Lim P, Suon S, Sreng S, Anderson JM, Mao S, Sam B, Sopha C, Chuor CM, Nguon C, Sovannaroth S, Pukrittayakamee S, Jittamala P, Chotivanich K, Chutasmit K, Suchatsoonthorn C, Runcharoen R, Hien TT, Thuy-Nhien NT, Thanh NV, Phu NH, Htut Y, Han KT, Aye KH, Mokuolu OA, Olaosebikan RR, Folaranmi OO, Mayxay M, Khanthavong M, Hongvanthong B, Newton PN, Onyamboko MA, Fanello CI, Tshefu AK, Mishra N, Valecha N, Phyo AP, Nosten F, Yi P, Tripura R, Borrmann S, Bashraheil M, Peshu J, Faiz MA, Ghose A, Hossain MA, Samad R, Rahman MR, Hasan MM, Islam A, Miotto O, Amato R, MacInnis B, Stalker J, Kwiatkowski DP, Bozdech Z, Jeeyapant A, Cheah PY, Sakulthaew T, Chalk J, Intharabut B, Silamut K, Lee SJ, Vihokhern B, Kunasol C, Imwong M, Tarning J, Taylor WJ, Yeung S, Woodrow CJ, Flegg JA, Das D, Smith J, Venkatesan M, Plowe CV, Stepniewska K, Guerin PJ, Dondorp AM, Day NP, White NJ; Tracking Resistance to Artemisinin Collaboration (TRAC). Spread of artemisinin resistance in Plasmodium falciparum malaria. New England Journal of Medicine 371:411-423, 2014. PMCID: PMC4143591.

114. Shekalaghe S, Rutaihwa M, Billingsley PF, Chemba M, Daubenberger CA, James ER, Mpina M, Ali Juma O, Schindler T, Huber E, Gunasekera A, Manoj A, Simon B, Saverino E, Church LW, Hermsen CC, Sauerwein RW, Plowe C, Venkatesan M, Sasi P, Lweno O, Mutani P, Hamad A, Mohammed A, Urassa A, Mzee T, Padilla D, Ruben A, Sim BK, Tanner M, Abdulla S, Hoffman SL. Controlled human malaria infection of Tanzanians by intradermal injection of aseptic, purified, cryopreserved Plasmodium falciparum sporozoites. American Journal of Tropical Medicine & Hygiene 91:471-880, 2014. PMCID: PMC4155546.

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115. Venkatesan M, Gadalla NB, Stepniewska K, Dahal P, Nsanzabana C, Moriera C, Price RN, Mårtensson A, Rosenthal PJ, Dorsey G, Sutherland CJ, Guérin P, Davis TM, Ménard D, Adam I, Ademowo G, Arze C, Baliraine FN, Berens-Riha N, Björkman A, Borrmann S, Checchi F, Dhorda MD, Djimdé AA, El-Sayed BB, Eshetu T, Eyase F, Falade C, Faucher JF, Fröberg G, Grivoyannis A, Hamour S, Houzé S, Johnson J, Kamugisha E, Kariuki S, Kiechel JR, Kironde F, LeBras PE, Malmberg M, Mwai L, Ngasala B, Nosten F, Nsobya SL, Oguike AN, Otienoburu SD, Ogutu B, Ouédraogo JB, Piola P, Rombo L, Schramm B, Somé AF, Thwing J, Ursing J, Wong RP, Zeynudin A, Zongo I, Plowe CV, Sibley CH. Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. American Journal of Tropical Medicine & Hygiene 91:833-843, 2014. PMCID: PMC4183414.

116. Jacob CG, Tan JC, Miller BA, Tan A, Takala-Harrison S, Ferdig MT, Plowe CV. A microarray platform and novel SNP calling algorithm to evaluate Plasmodium falciparum field samples of low DNA quantity. BMC Genomics 15:719, 2014. PMCID: PMC4153902.

117. Takala-Harrison S, Jacob CG, Arze C, Cummings MP, Silva JC, Dondorp AM, Fukuda MM, Hien TT, Mayxay M, Noedl H, Nosten F, Kyaw MP, Nhien NT, Imwong M, Bethell D, Se Y, Lon C, Tyner SD, Saunders DL, Ariey F, Mercereau-Puijalon O, Menard D, Newton PN, Khanthavong M, Hongvanthong B, Starzengruber P, Fuehrer HP, Swoboda P, Khan WA, Phyo AP, Nyunt MM, Nyunt MH, Brown TS, Adams M, Pepin CS, Bailey J, Tan JC, Ferdig MT, Clark TG, Miotto O, MacInnis B, Kwiatkowski DP, White NJ, Ringwald P, Plowe CV. Independent emergence of Plasmodium falciparum artemisinin resistance mutations in Southeast Asia. Journal of Infectious Diseases 211:670-79, 2014. PMCID: PMC4334802.

118. Coulibaly D, Travassos MA, Kone AK, Tolo Y, Laurens MB, Traore K, Diarra I, Niangaly A, Daou M, Dembele A, Sissoko M, Guindo B, Douyon R, Guindo A, Kouriba B, Sissoko MS, Sagara I, Plowe CV, Doumbo OK, Thera MA. Stable malaria incidence despite scaling up control strategies in a malaria vaccine testing site in Mali. Malaria Journal 13:374, 2014. PMCID: PMC4180968.

119. Bailey JA, Pablo J, Niangaly A, Travassos MA, Ouattara A, Coulibaly D, Laurens MB, Takala-Harrison SL, Lyke KE, Skinner J, Berry AA, Jasinskas A, Nakajima-Sasaki R, Kouriba B, Thera MA, Felgner PL, Doumbo OK, Plowe CV. Seroreactivity to a large panel of field-derived Plasmodium falciparum apical membrane antigen 1 and merozoite surface protein 1 variants reflects seasonal and lifetime acquired responses to malaria. . American Journal of Tropical Medicine & Hygiene 92:9-12, 2015. PMCID: PMC4347399.

120. Brown TS, Jacob CG, Silva JC, Takala-Harrison S, Djimdé A, Dondorp AM, Fukuda M, Noedl H, Nyunt MM, Kyaw MP, Mayxay M, Hien TT, Plowe CV, Cummings MP. Plasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotype. Infection, Genetics and Evolution 30:318-322, 2015. PMCID: PMC4316729.

121. Miotto O, Amato R, Ashley EA, MacInnis B, Almagro-Garcia J, Amaratunga C, Lim P, Mead D, Oyola SO, Dhorda M, Imwong M, Woodrow C, Manske M, Stalker J, Drury E, Campino S, Amenga-Etego L, Thanh TN, Tran HT, Ringwald P, Bethell D, Nosten F, Phyo AP, Pukrittayakamee S, Chotivanich K, Chuor CM, Nguon C, Suon S, Sreng S, Newton PN, Mayxay M, Khanthavong M, Hongvanthong B, Htut Y, Han KT, Kyaw MP, Faiz MA, Fanello CI, Onyamboko M, Mokuolu OA, Jacob CG, Takala-Harrison S, Plowe CV, Day NP, Dondorp AM, Spencer CC, McVean G, Fairhurst RM, White NJ, Kwiatkowski DP. Genetic architecture of artemisinin-resistant Plasmodium falciparum. Nature Genetics 47:226-234, 2015. PMCID: PMC4545236.

122. Artimovich E, Schneider K, Taylor TE, Kublin JG, Dzinjalamala FK, Escalante AA, Plowe CV, Laufer MK, Takala-Harrison S. Persistence of sulfadoxine-pyrimethamine resistance despite reduction of drug pressure in Malawi. Journal of Infectious Diseases 212:694-701, 2015. PMCID: PMC4539899.

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123. White LJ, Flegg JA, Phyo AP, Wiladpai-Ngern JH, Bethell D, Plowe C, Anderson T, Nkhoma S, Nair S, Tripura R, Stepniewska K, Pan-Ngum W, Silamut K, Cooper BS, Lubell Y, Ashley EA, Nguon C, Nosten F, White NJ, Dondorp AM. Defining the in vivo phenotype of artemisinin-resistant falciparum malaria: a modeling approach. PLoS Medicine 2:e1001823, 2015. PMCID: PMC4412633.

124. Ouattara A, Kone A, Adams M, Fofana B, Maiga AW, Hampton S, Coulibaly D, Thera MA, Diallo N, Dara A, Sagara I, Gil JP, Bjorkman A, Takala-Harrison S, Doumbo OK, Plowe CV, Djimde AA. Polymorphisms in the K13-propeller gene in artemisinin susceptible Plasmodium falciparum parasites from Bougoula-Hameau and Bandiagara, Mali. American Journal of Tropical Medicine & Hygiene 92:1202-1206, 2015. PMCID PMC4458826.

125. Travassos MA, Coulibaly D, Bailey JA, Niangaly A, Adams M, Nyunt MM, Ouattara A, Lyke KE, Laurens MB, Pablo J, Jasinskas A, Nakajima-Sasaki R, Berry AA, Takala-Harrison S, Kone AK, Kouriba B, Rowe JA, Doumbo OK, Thera MA, Laufer MK, Felgner PL, Plowe CV. Differential recognition of terminal extracellular Plasmodium falciparum VAR2CSA domains by Sera from multigravida, malaria-exposed Malian women. American Journal of Tropical Medicine & Hygiene 92:1190-1194, 2015. PMCID: PMC4458824.

126. Huang F, Takala-Harrison S, Jacob CG, Liu H, Sun X, Yang H, Nyunt MM, Adams M, Zhou S, Xia Z, Ringwald P, Bustos MD, Tang L, Plowe CV. A single mutation in K13 predominates in southern China and is associated with delayed clearance of Plasmodium falciparum following artemisinin treatment. Journal of Infectious Diseases 212:1629-1635, 2015. PMCID: PMC4621243.

127. Chaorattanakawee S, Saunders DL, Sea D, Chanarat N, Yingyuen K, Sundrakes S, Saingam P, Buathong N, Sriwichai S, Chann S, Se Y, Yom Y, Heng TK, Kong N, Kuntawunginn W, Tangthongchaiwiriya K, Jacob C, Takala-Harrison S, Plowe C, Lin JT, Chuor CM, Prom S, Tyner SD, Gosi P, Teja-Isavadharm P, Lon C, Lanteri CA. Ex vivo drug susceptibility and molecular profiling of clinical Plasmodium falciparum isolates from Cambodia in 2008-2013 suggest emerging piperaquine resistance. Antimicrobial Agents and Chemotherapy 59:4631-4643, 2015. PMCID: PMC4505231.

128. Travassos MA, Coulibaly D, Laurens MB, Dembélé A, Tolo Y, Koné AK, Traoré K, Niangaly A, Guindo A, Wu Y, Berry AA, Jacob CG, Takala-Harrison S, Adams M, Shrestha B, Mu AZ, Kouriba B, Lyke KE, Diallo DA, Doumbo OK, Plowe CV, Thera MA. Hemoglobin C Trait provides protection from clinical falciparum malaria in Malian children. Journal of Infectious Diseases 212:1778-1786, 2015. PMCID: PMC4633765.

129. Lyke KE, Laurens MB, Strauss K, Adams M. Billingsley PF, James E, Manoj A, Chakravarty S, Plowe CV, Li ML, Ruben A, Edelman R, Green M, Dube TJ, Sim BK, Hoffman SL. Optimizing intradermal administration of cryopreserved Plasmodium falciparum sporozoites in Controlled Human Malaria Infection. American Journal of Tropical Medicine & Hygiene 93:1274-12184, 2015. PMCID: PMC4674246.

130. Adams M, Joshi SN, Mbambo G, Mu ZA, Roemmich SM, Shrestha B, Strauss KA, Johnson NE, Oo KZ, Hlaing TM, Han ZY, Han KT, Thura S, Richards AK, Huang F, Nyunt MM, Plowe CV. An ultrasensitive reverse transcription polymerase chain reaction assay to detect asymptomatic low-density Plasmodium falciparum and Plasmodium vivax infections in small volume blood samples. Malaria Journal 14:520, 2015. PMCID: PMC4690410.

131. MalariaGEN Plasmodium falciparum Community Project. Genomic epidemiology of artemisinin resistant malaria. Elife 5:e08714, 2016. PMCID: PMC4786412

132. Sobota RS, Dara A, Manning JE, Niangaly A, Bailey JA, Kone AK, Thera MA, Djimdé AA, Vernet G, Leissner P, Williams SM, Plowe CV, and Doumbo OK. Expression of complement and toll-like receptor pathway genes is associated with malaria severity in Mali: a pilot case control study. Malaria Journal 15:150, 2016. PMCID: PMC4784286.

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133. Graves SF, Kouriba B, Diarra I, Daou M, Niangaly A, Coulibaly D, Keita Y, Laurens MB, Berry AA, Vekemans J, Ripley Ballou W, Lanar DE, Dutta S, Gray Heppner D, Soisson L, Diggs CL, Thera MA, Doumbo OK, Plowe CV, Sztein MB, Lyke KE. Strain-specific Plasmodium falciparum multifunctional CD4+ T cell cytokine expression in Malian children immunized with the FMP2.1/AS02A vaccine candidate. Vaccine 34:2546-2555, 2016.

134. Ishizuka AS, Lyke KE, DeZure A, Berry AA, Richie TL, Mendoza FH, Enama ME, Gordon IJ, Chang LJ, Sarwar UN, Zephir KL, Holman LA, James ER, Billingsley PF, Gunasekera A, Chakravarty S, Manoj A, Li M, Ruben AJ, Li T, Eappen AG, Stafford RE, K C N, Murshedkar T, DeCederfelt H, Plummer SH, Hendel CS, Novik L, Costner PJ, Saunders JG, Laurens MB, Plowe CV, Flynn B, Whalen WR, Todd JP, Noor J, Rao S, Sierra-Davidson K, Lynn GM, Epstein JE, Kemp MA, Fahle GA, Mikolajczak SA, Fishbaugher M, Sack BK, Kappe SH, Davidson SA, Garver LS, Björkström NK, Nason MC, Graham BS, Roederer M, Sim BK, Hoffman SL, Ledgerwood JE, Seder RA. Protection against malaria at 1 year and immune correlates following PfSPZ vaccination. Nature Medicine 22:614-23, 2016.

135. Laurens MB, Mungwira RG, Nyirenda OM, Divala TH, Kanjala M, Muwalo F, Mkandawire FA, Tsirizani L, Nyangulu W, Mwinjiwa E, Taylor TE, Mallewa J, Blackwelder WC, Plowe CV, Laufer MK, van Oosterhout JJ. TSCQ study: a randomized, controlled, open-label trial of daily trimethoprim-sulfamethoxazole or weekly chloroquine among adults on antiretroviral therapy in Malawi: study protocol for a randomized controlled trial. Trials. 17:322, 2016. PMCID: PMC4950772.

136. Busby GB, Band G, Si Le Q, Jallow M, Bougama E, Mangano VD, Amenga-Etego LN, Enimil A, Apinjoh T, Ndila CM, Manjurano A, Nyirongo V, Doumbo O, Rockett KA, Kwiatkowski DP, Spencer CC; Malaria Genomic Epidemiology Network. Admixture into and within sub-Saharan Africa. Elife 5 e15266, 2016. PMCID: PMC4915815.

137. Lyke KE, Ishizuka AS, Berry AA, Chakravarty S, DeZure A, Enama ME, James ER, Billingsley PF, Gunasekera A, Manoj A, Li M, Ruben AJ, Li T, Eappen AG, Stafford RE, Kc N, Murshedkar T, Mendoza FH, Gordon IJ, Zephir KL, Holman LA, Plummer SH, Hendel CS, Novik L, Costner PJ, Saunders JG, Berkowitz NM, Flynn BJ, Nason MC, Garver LS, Laurens MB, Plowe CV, Richie TL, Graham BS, Roederer M, Sim BK, Ledgerwood JE, Hoffman SL, Seder RA. Attenuated PfSPZ Vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infection. Proc Natl Acad Sci U S A 114:2711-2716, 2017.

138. Laurens MB, Kouriba B, Bergmann-Leitner E, Angov E, Coulibaly D, Diarra I, Daou M, Niangaly A,

Blackwelder WC, Wu Y, Cohen J, Ballou WR, Vekemans J, Lanar DE, Dutta S, Diggs C, Soisson L, Heppner DG, Doumbo OK, Plowe CV, Thera MA. Strain-specific Plasmodium falciparum growth inhibition among Malian children immunized with a blood-stage malaria vaccine. PLoS One 12:e0173294, 2017. PMCID: PMC5345808.

139. Dara A, Drábek EF, Travassos MA, Moser KA, Delcher AL, Su Q, Hostelley T, Coulibaly D, Daou M,

Dembele A, Diarra I, Kone AK, Kouriba B, Laurens MB, Niangaly A, Traore K, Tolo Y, Fraser CM, Thera MA, Djimde AA, Doumbo OK, Plowe CV, Silva JC. New var reconstruction algorithm exposes high var sequence diversity in a single geographic location in Mali. Genome Medicine 9:30, 2017. PMCID: PMC5368897.

140. Niangaly A, Karthigayan Gunalan, Amed Ouattara, Coulibaly D, Sá JM, Adams M, Travassos MA,

Ferrero J, Laurens MB, Kone AK, Thera MA, Plowe CV, Miller LH, Doumbo OK. Plasmodium vivax infections over 3 years in Duffy blood group negative Malians in Bandiagara, Mali. American Journal of Tropical Medicine & Hygiene 97:744-752, 2017.

141. Dara A, Travassos MA, Adams M, Schaffer DeRoo S, Drábek EF, Agrawal S, Laufer MK, Plowe CV,

Silva JC. A new method for sequencing the hypervariable Plasmodium falciparum gene var2csa from clinical samples. Malaria Journal 16:343, 2017. PMCID: PMC5561619.

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142. Boudová S, Walldorf JA, Bailey JA, Divala T, Mungwira R, Mawindo P, Pablo J, Jasinskas A, Nakajima

R, Ouattara A, Adams M, Felgner PL, Plowe CV, Travassos MA, Laufer MK. Mother-newborn pairs in Malawi have similar antibody repertoires to diverse malaria antigens. Clinical Vaccines & Immunology 24:e00136-17, 2017. PMCID: PMC5629668.

143. Zainabadi K, Adams M, Han ZY, Lwin HW, Han KT, Ouattara A, Thura S, Plowe CV, Nyunt MM. A

novel method for extracting nucleic acids from dried blood spots for ultrasensitive detection of low-density Plasmodium falciparum and Plasmodium vivax infections. Malaria Journal 16:377, 2017. PMCID: PMC5604154.

144. Agrawal S, Moser KA, Morton L, Cummings MP, Parihar A, Dwivedi A, Shetty AC, Drabek EF, Jacob

CG, Henrich PP, Parobek CM, Jongsakul K, Huy R, Spring MD, Lanteri CA, Chaorattanakawee S, Lon C, Fukuda MM, Saunders DL, Fidock DA, Lin JT, Juliano JJ, Plowe CV, Silva JC, Takala-Harrison S. Association of a novel mutation in the Plasmodium falciparum Chloroquine Resistance Transporter with decreased piperaquine sensitivity. Journal of Infectious Diseases 216:468-476, 2017.

145. Huang F, Takala-Harrison S, Liu H, Xu JW, Yang HL, Adams M, Shrestha B, Mbambo G, Rybock D,

Zhou SS, Xia ZG, Zhou XN, Plowe CV, Nyunt MM. Prevalence of clinical and subclinical Plasmodium falciparum and Plasmodium vivax malaria in two remote rural communities on the Myanmar-China border. American Journal of Tropical Medicine & Hygiene 2017 Nov; 97(5):1524-1531. doi: 10.4269/ajtmh.17-0167. Epub 2017 Oct 10. PubMed PMID: 29016341; PubMed Central PMCID: PMC5817756.

146. Coulibaly D, Travassos MA, Tolo Y, Laurens MB, Kone AK, Traore K, Sissoko M, Niangaly A, Diarra I,

Daou M, Guindo B, Rebaudet S, Kouriba B, Dessay N, Piarroux R, Plowe CV, Doumbo OK, Thera MA, Gaudart J. Spatio-temporal dynamics of asymptomatic malaria: Bridging the gap between annual malaria resurgences in a Sahelian environment. American Journal of Tropical Medicine & Hygiene 2017 Dec;97(6):1761-1769. doi: 10.4269/ajtmh.17-0074. Epub 2017 Oct 19. PubMed PMID: 29141722; PubMed Central PMCID: PMC5805033.

147. Taghavian O, Jain A, Joyner CJ, Ketchum S, Nakajima R, Jasinskas A, Liang L, Fong R, King C,

Greenhouse B, Murphy M, Bailey J, Galinski MR, Barnwell JW, Plowe CV, Davies DH, Felgner PL. Antibody profiling by proteome microarray with multiplex isotype detection reveals overlap between human and Aotus nancymaae controlled malaria infections. Proteomics. 2018 Jan;18(2). doi:10.1002/pmic.201700277. Erratum in: Proteomics. 2018 Jul;18(13):e1870115. PubMed PMID: 29266845.

148. Arama C, Diarra I, Kouriba B, Sirois F, Fedoryak O, Thera MA, Coulibaly D, Lyke KE, Plowe CV,

Chrétien M, Doumbo OK, Mbikay M. Malaria severity: Possible influence of the E670G PCSK9 polymorphism: A preliminary case-control study in Malian children. PLoS One. 2018 Feb15;13(2):e0192850. doi:10.1371/journal.pone.0192850. eCollection 2018. PubMed PMID: 29447211; PubMed Central PMCID: PMC5813955.

149. Lyke KE, Dabo A, Arama C, Diarra I, Plowe CV, Doumbo OK, Sztein MB. Long-term Maintenance of

CD4 T Cell Memory Responses to Malaria Antigens in Malian Children Coinfected with Schistosoma haematobium. Front Immunol. 2018 Feb 1;8:1995. doi:10.3389/fimmu.2017.01995. eCollection 2017. PubMed PMID: 29449839; PubMed Central PMCID: PMC5799235.

150. Travassos MA, Niangaly A, Bailey JA, Ouattara A, Coulibaly D, Lyke KE, Laurens MB, Pablo J,

Jasinskas A, Nakajima R, Berry AA, Adams M, Jacob CG, Pike A, Takala-Harrison S, Liang L, Kouriba B, Kone AK, Rowe JA, Moulds J, Diallo DA, Doumbo OK, Thera MA, Felgner PL, Plowe CV. Children with cerebral malaria or severe malarial anaemia lack immunity to distinct variant surface

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antigen subsets. Sci Rep. 2018 Apr 19;8(1):6281. doi: 10.1038/s41598-018-24462-4. PubMed PMID: 29674705; PubMed Central PMCID: PMC5908851.

151. Opi DH, Swann O, Macharia A, Uyoga S, Band G, Ndila CM, Harrison EM, Thera MA, Kone AK, Diallo

DA, Doumbo OK, Lyke KE, Plowe CV, Moulds JM, Shebbe M, Mturi N, Peshu N, Maitland K, Raza A, Kwiatkowski DP, Rockett KA, Williams TN, Rowe JA. Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α(+)thalassaemia. Elife. 2018 Apr 25;7. pii: e31579. doi: 10.7554/eLife.31579. PubMed PMID: 29690995; PubMed Central PMCID: PMC5953541.

152. Ouattara A, Tran TM, Doumbo S, Matthew A, Agrawal S, Niangaly A, Nelson-Owens S, Doumtabé D,

Tolo Y, Ongoiba A, Takala-Harrison S, Traoré B, Silva JC, Crompton PD, Doumbo OK, Plowe CV. Extent and dynamics of polymorphism in the malaria vaccine candidate Plasmodium falciparum Reticulocyte-Binding Protein Homologue-5 in Kalifabougou, Mali. Am J Trop Med Hyg. 2018 Jul;99(1):43-50. doi:10.4269/ajtmh.17-0737. Epub 2018 May 24. PubMed PMID: 29848401.

153. Taghavian O, Jain A, Joyner CJ, Ketchum S, Nakajima R, Jasinskas A, Liang L, Fong R, King C,

Greenhouse B, Murphy M, Bailey J, Galinski MR, Barnwell JW, Plowe CV, Davies DH, Felgner PL. Antibody Profiling by Proteome Microarray with Multiplex Isotype Detection Reveals Overlap between Human and Aotus nancymaae Controlled Malaria Infections. Proteomics. 2018 Jul;18(13):e1870115. doi:10.1002/pmic.201870115. Epub 2018 Jun 11. PubMed PMID: 29963771.

154. Ndila CM, Uyoga S, Macharia AW, Nyutu G, Peshu N, Ojal J, Shebe M, Awuondo KO, Mturi N, Tsofa

B, Sepúlveda N, Clark TG, Band G, Clarke G, Rowlands K, Hubbart C, Jeffreys A, Kariuki S, Marsh K, Mackinnon M, Maitland K, Kwiatkowski DP, Rockett KA, Williams TN; MalariaGEN Consortium. Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study. Lancet Haematol. 2018 Aug;5(8):e333-e345. doi: 10.1016/S2352-3026(18)30107-8. Epub 2018 Jul 20. PMID: 30033078

Non-refereed publications: Book Reviews: 1. Plowe CV. Review of The Fever: how malaria has ruled humankind for 500,000 years. The Journal of

Clinical Investigation 120:4167, 2010.

2. Plowe CV. Review of Vaccine Design: Innovative Approaches and Novel Strategies. Clinical Infectious Diseases 53:318, 2011.

Reports: 1. Plowe CV. The Danger of Untreatable Malaria is Real and Present. A Report of the Center for Strategic

and International Studies (CSIS) Global Health Policy Center, December 2014. http://csis.org/files/publication/141202_Plowe_DangerUntreatableMalaria_Web.pdf

Chapters in books: 1. Plowe CV. Malaria. Red Book: Report of the Committee on Infectious Diseases, 24th Ed., American

Academy of Pediatrics. Peter G (ed.) 1997.

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2. Plowe CV. Folate antagonists and mechanisms of resistance. Antimalarial Chemotherapy, Infectious Diseases Series, Humana Press. Rosenthal P (ed.) 2001.

3. Cao K, Lyke KE, Masaberg C, Doumbo O, Ng J, Hartzman R, Plowe CV, Sztein M, Fernández-Viña M. Distribution and association of alleles at the HLA class I-A, B and C loci in a Malian population. HLA 2002. Immunobiology of the Human MHC. Hansen, J and Dupont, B, (eds.) 2003.

4. Nyunt M, Plowe CV. Malaria. Pharmacology and therapeutics: principles to practice. Saunders. Waldman SA, Terzic A (eds.) 2009.

5. Berry A, Nyunt M, Plowe CV. Malaria: Clinical and epidemiological aspects. Immunology of Infectious Diseases. ASM Press. Kaufmann S, Rouse B, Sacks D (eds.), 2010.

6. Tapia MD, Kotloff KL, Plowe CV, Sow SO. Special issues in performing vaccine trials in developing countries. New Generation Vaccines. Informa Healthcare. Levine MM, Dougan G, Good MF, Liu MA, Nabel GJ, Nataro JP, Rappuoli R (eds.) 2010.

7. Weijer C, Lanata CF, Plowe CV. Ethical considerations in the conduct of vaccine trials in developing countries. New Generation Vaccines. Informa Healthcare. Levine MM, Dougan G, Good MF, Liu MA, Nabel GJ, Nataro JP, Rappuoli R (eds.) 2010.

8. Jacob C, Plowe CV. Malaria genomics and the developing world. Genomics Applications for the Developing World. Nelson KE, Jones-Nelson, B (eds.) 2012.

9. Plowe CV. Malaria vaccines. Encyclopedia of Sustainability Science and Technology. Springer. Kanki P, Meyers R (eds.) 2013.

Other: a. Published scientific reviews (for mass distribution) 1. Plowe CV, Wellems T. Molecular approaches to the spreading problem of drug resistant malaria.

Advances in Experimental Medicine and Biology 390:197-209, 1995.

2. Plowe CV, Kublin JG, Doumbo OK. P. falciparum DHFR and DHPS mutations: Epidemiology and role in clinical resistance to antifolates. Drug Resistance Updates 1:389-396, 1998.

3. Carlton JM, Fidock DA, Djimde A, Plowe CV, Wellems T. Conservation of a novel vacuolar transporter in Plasmodium species and its central role in chloroquine resistance of P. falciparum. Current Opinions in Microbiology 4:415-420, 2001.

4. Wellems TE, Plowe CV. Chloroquine-resistant malaria. Journal of Infectious Diseases 184:770-776, 2001.

5. Sibley C, Hyde J, Sims P, Plowe C, Kublin J, Mberu E, Cowman A, Winstanley P, Watkins W, Nzila A. Pyrimethamine/sulfadoxine resistance in Plasmodium falciparum: What next? Trends in Parasitology 17:582-588, 2001.

6. Plowe CV. Monitoring antimalarial drug resistance: making the most of the tools at hand. Journal of Experimental Biology 206:3745-3752, 2003.

7. Laufer MK, Plowe CV. Withdrawing antimalarial drugs: Impact on parasite resistance and implications for malaria treatment policies. Drug Resistance Updates 7:279-288, 2004.

8. Gregson A, Plowe CV. Mechanisms of resistance of malaria parasites to antifolates. Pharmacological Reviews 57:117-145, 2005.

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9. Heppner DG, Kester KE, Ockenhouse CF, Tornieporth N, Ofori O, Lyon JA, Stewart VA, Dubois P, Lanar DE, Krzych U, Moris P, Angov E, Cummings J, Leach A, Hall B, Dutta S, Schwenk R, Hillier C, Barbosa A, Ware L, Nair L, Darko CA, Withers MR, Ogutu B, Polhemus ME, Fukuda M, Pichyangkul S, Gettyacamin M, Diggs C, Soisson L, Milman J, Dubois M, Garcon N, Tucker K, Wittes J, Plowe CV, Thera M, Doumbo OK, Pau MG, Goudsmit J, Ballou WR, Cohen J. Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research. Vaccine 23:2243-2250, 2005.

10. Plowe CV. Antimalarial drug resistance in Africa: Strategies for monitoring and deterrence. Current Topics in Microbiology and Immunology 295:55-79, 2005.

11. Laufer MK, Plowe CV. The interaction between HIV and malaria in Africa. Current Infectious Disease Reports 9:47-54, 2007.

12. Nyunt MM, Plowe CV. Pharmacologic advances in the global control and treatment of malaria: combination therapy and resistance. Clinical Pharmacology and Therapeutics 82:601-605, 2007.

13. Sibley CH, Barnes KI, Plowe CV. The rationale and plan for creating a World Antimalarial Resistance Network (WARN). Malaria Journal 6:118, 2007.

14. Barnes KI, Lindegardh N, Ogundahunsi O, Olliaro P, Plowe CV, Randrianarivelojosia M, Gbotosho GO, Watkins WM, Sibley CH, White NJ. World Antimalarial Resistance Network (WARN) IV: clinical pharmacology. Malaria Journal 6:122, 2007.

15. Plowe CV, Roper C, Barnwell JW, Happi CT, Joshi HH, Mbacham W, Meshnick SR, Mugittu K, Naidoo I, Price RN, Shafer RW, Sibley CH, Sutherland CJ, Zimmerman PA, Rosenthal PJ. World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria. Malaria Journal 6:121, 2007.

16. Price RN, Dorsey G, Ashley EA, Barnes KI, Baird JK, d'Alessandro U, Guerin PJ, Laufer MK, Naidoo I, Nosten F, Olliaro P, Plowe CV, Ringwald P, Sibley CH, Stepniewska K, White NJ. World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs. Malaria Journal 6:119, 2007.

17. Laufer ML, Djimde AA, Plowe CV. Monitoring and deterring drug resistant malaria in the era of combination therapy. American Journal of Tropical Medicine & Hygiene 77:160-169, 2007.

18. Sibley CH, Barnes KI, Watkins WM, Plowe CV. A network to monitor antimalarial drug resistance: a plan for moving forward. Trends in Parasitology 24:43-48, 2008.

19. Plowe CV. The evolution of drug-resistant malaria. Transactions of the Royal Society of Tropical Medicine & Hygiene, 103:S11-14, 2009.

20. Takala SL, Plowe CV. Genetic diversity and malaria vaccine design, testing and efficacy: preventing and overcoming 'vaccine resistant malaria'. Parasite Immunology 31:560-573, 2009.

21. Plowe CV, Alonso P, Hoffman SL. The potential role of vaccines in the elimination of falciparum malaria and the eventual eradication of malaria. Journal of Infectious Diseases 200:1646-1649, 2009.

22. Hoffman SL, Billingsley PF, James E, Richman A, Loyevsky M, Li T, Chakravarty S, Gunasekera A, Li M, Stafford R, Ahumada A, Epstein JE, Sedegah M, Reyes S, Richie TL, Lyke KE, Edelman R, Laurens M, Plowe CV, Sim BK. Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria. Human Vaccines 6:97-106, 2010.

23. Alonso PL, Brown G, Arevalo-Herrera M, Binka F, Chitnis C, Collins F, Doumbo OK, Greenwood B, Hall BF, Levine MM, Mendis K, Newman N, Plowe CV, Rodríguez MH, Sinden R, Slutsker L, Tanner M. A research agenda to underpin malaria eradication. PLoS Medicine 8:e1000406, 2011.

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24. The malERA Consultative Group on Drugs (corresponding author). A Research Agenda for Malaria Eradication: Drugs. PLoS Medicine 8:e1000402, 2011.

25. The malERA Consultative Group on Vaccines. A Research Agenda for Malaria Eradication: Vaccines. PLoS Medicine 8:e1000398, 2011.

26. Thera MA, Plowe CV. Vaccines for malaria: how close are we? Annual Review of Medicine 63:345-357, 2012.

27. Fairhurst RM, Nayyar GM, Breman JG, Hallett R, Vennerstrom JL, Duong S, Ringwald P, Wellems TE, Plowe CV, Dondorp AM. Artemisinin-resistant malaria: research challenges, opportunities, and public health implications. American Journal of Tropical Medicine & Hygiene 87:231-241, 2012.

28. Venkatesan M, Alifrangis M, Roper C, Plowe CV. Monitoring antifolate resistance in intermittent preventive therapy for malaria. Trends in Parasitology 29:497-504, 2013.

29. Plowe CV. The Jeremiah Metzger lecture: new additions to the toolbox for global malaria eradication. Transactions of the American Clinical and Climatological Association 125:271-280, 2014.

30. Ouattara A, Barry AE, Dutta S, Remarque EJ, Beeson JG, Plowe CV. Designing malaria vaccines to circumvent antigen variability. Vaccine 33:7506-7512, 2015.

c: Editorials, position, and background papers: 1. Laufer MK, Plowe CV. Cotrimoxazole prophylaxis and malaria in Africa: Have the important questions

been answered? American Journal of Tropical Medicine & Hygiene 75:373-374, 2006.

2. Plowe CV. Combination therapy for malaria: Mission accomplished? Clinical Infectious Diseases 44:1075-1077, 2007.

3. Breman JG, Plowe CV. A malaria vaccine for control: more progress. Journal of Infectious Diseases 200:317-320, 2009.

4. Plowe CV, Alonso P, Hoffman SL. The potential role of vaccines in the elimination of falciparum malaria and the eventual eradication of malaria. Journal of Infectious Diseases 200:1646-1649, 2009.

5. Dondorp AM, Fairhurst RM, Slutsker L, MacArthur JR, Breman JG, Guerin PJ, Wellems TE, Ringwald P, Newman RD, Plowe CV. Perspective: The threat of Artemisinin-resistant malaria. New England Journal of Medicine 365:1075-1077, 2011.

6. Plowe CV. Resistance nailed. Nature News & Views 505:30-31, 2014.

7. Plowe CV. Vaccine-resistant malaria. New England Journal of Medicine 373:2082-2083, 2015.

8. Nyunt MM and Plowe C. Malaria as a Catalyst for Change in Myanmar [Commentary]. Roll Call, August 18, 2015.

9. Nyunt MM and Plowe C. Pursuing disease diplomacy in Myanmar [Op-Ed]. The Los Angeles Times, December 14, 2015.

10. Plowe CV. Presidential Address: Tropical medicine in war and peace. American Journal of Tropical Medicine & Hygiene 95:5-9, 2016.

11. Plowe CV. In Memoriam: A Tribute to Alan Magill. Trends in Parasitology 32:265-266, 2016.

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12. Rosenthal PJ, Hill DR, Bausch DG, Goraleski KA, Higgs S, Walker PF, Plowe CV. The (International) American Society of Tropical Medicine & Hygiene. American Journal of Tropical Medicine & Hygiene 95:980-982, 2017.

13. Rosenthal PJ, Bausch DG, Higgs S, Rabinovich NR, Hill DR, Plowe CV, Goraleski KA, Walker PF. Evidence-based policies on migration and global health are essential to maintain the health of those inside and outside the United States. American Journal of Tropical Medicine & Hygiene 96:5-6, 2017.

14. Djimdé A, Miller LH, Plowe CV. Professor Ogobara K. Doumbo (1956-June 9, 2018). Am J Trop Med Hyg. 2018 Nov;99(5):1118-1119. doi: 10.4269/ajtmh.18-1956. PMID: 30350778

Professional awards and special recognitions: 1998 Wall of Fame Outstanding Faculty Award in Host Defenses & Infectious Diseases, awarded by Class of 2001, University of Maryland School of Medicine

2002 Bailey K. Ashford Medal, American Society of Tropical Medicine & Hygiene, awarded for distinguished work in tropical medicine

2005 Elected to American Society for Clinical Investigation, National Honor Society of Physician-Scientists

2007 Doris Duke Distinguished Clinical Scientist Award, Doris Duke Charitable Foundation

2007 Howard Hughes Medical Institute Investigator in Patient-Oriented Research, Howard Hughes Medical Institute

2007 Teaching Commendation in Host Defenses & Infectious Diseases awarded by Class of 2010, University of Maryland School of Medicine

2008 Mary Betty Stevens Award for Excellence in Clinical Investigation, awarded by Maryland Chapter, American College of Physicians

2008 Teaching Commendation in Host Defenses & Infectious Diseases, awarded by Class of 2011, University of Maryland School of Medicine

2010 Faculty Teacher of the Year Award, Department of Medicine, Division of Geographic Medicine, University of Maryland School of Medicine

2010, 2012, 2013 Clinical Publication of the Year Award, Department of Medicine, University of Maryland School of Medicine

2013 Award for Outstanding Work in Science as Related to Medicine, American College of Physicians

2013 Fellow, American Society of Tropical Medicine & Hygiene

2013 Champion of Excellence, University of Maryland Baltimore

2014-2015 President, American Society of Tropical Medicine & Hygiene

2015 Elected to American Clinical and Climatological Association

2016 Faculty Teacher of the Year, Department of Medicine, Division of Geographic Medicine, University of Maryland School of Medicine

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2016 Frank M. Calia MD Professor of Medicine, University of Maryland School of Medicine Endowed Professorship Organizations and participation: American Society of Tropical Medicine & Hygiene American Public Health Association American Committee on Clinical Tropical Medicine and Travelers Health American Society for Clinical Investigation American Association for the Advancement of Science American Clinical and Climatological Association

Invited Speeches and Grand Rounds: Local

1. Molecular epidemiology of pyrimethamine and proguanil resistant P. falciparum in Mali. 638th meeting of The Helminthological Society of Washington, November 1993.

2. Drug resistance and malaria in Africa: Molecular field epidemiology is not an oxymoron. Tropical Medicine Association of Washington, February 1994.

3. Malaria. Medical Grand Rounds, Department of Medicine, University of Maryland School of Medicine, May 1996.

4. Clinical Malaria. Emergency Medicine Grand Rounds, University of Maryland School of Medicine, July 1996.

5. Drug resistant malaria: Evolutionary genetics and new tools for surveillance. Tropical Medicine Dinner Club of Baltimore, December 1997.

6. A molecular marker for chloroquine resistant falciparum malaria. The Helminthological Society of Washington, 669th Meeting, Rockville, Maryland, March 2000.

7. Molecular markers for drug resistance: From genetic sequence to malaria control. Invited speaker, Malaria: Progress, Problems & Plans in the Genomic Era, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, January 2002.

8. From herbs to genomics: Malaria chemotherapy and drug resistance in the last twenty-one centuries, Tropical Medicine Dinner Club of Baltimore, Annual Banquet, April 2002.

9. Malaria: Global disaster, local liability. Medical Grand Rounds, Department of Medicine, University of Maryland School of Medicine, May 2003.

10. Antigenic diversity and malaria vaccine efficacy. Baltimore-Washington Malaria Meeting, Johns Hopkins Malaria Research Institute, February 2007.

11. From bench to bedside: Antimalarial drug resistance in Africa. Fifth Annual Clinical Investigator Student Trainee (CIST) Forum, Bethesda, Maryland, October 2007.

12. Vaccine resistant malaria. National Institutes of Health Twinbrook Seminar Series, Rockville, Maryland, January 2009.

13. A 36 year-old woman with fever, chills, and myalgias. Clinicopathologic Conference, Medical Grand Rounds, Department of Medicine, University of Maryland School of Medicine, January 2009.

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14. Clinical research in Africa: Interacting with local study populations and local scientists. Student National Medical Association Culture Competence Talk, University of Maryland, Baltimore, Maryland, January 2009.

15. Application of genomics to evaluation of malaria vaccine clinical trials. National Foundation for Infectious Diseases (NFID) Twelfth Annual Conference on Vaccine Research, Baltimore, Maryland, April 2009.

16. Extreme polymorphism in a malaria vaccine antigen is associated with clinical illness: Vaccine development implications. University of Maryland School of Medicine Council Meeting, May 2009.

17. Can malaria be eradicated? World Malaria Day Keynote Lecture. Walter Reed Army Institute of Research and Navy Medical Research Center, Silver Spring, Maryland, April 2011.

18. Research toward malaria eradication at the University of Maryland. University of Maryland Medical System (UMMS) Board of Directors Meeting, Baltimore, Maryland, November 2011.

19. Can malaria be eradicated? Medical Grand Rounds, Department of Medicine, University of Maryland School of Medicine, December 2011.

20. Wrestling with malaria. Food for Thought Internal Talk Series, Howard Hughes Medical Institute, Chevy Chase, Maryland, April 2012.

21. Malaria Vaccines. University of Maryland School of Medicine 2014 Festival of Science: Infections, Inflammation & Vaccines, Baltimore, Maryland, December 2014.

22. Plans for Synergy between the New Institute Dedicated to Vaccine Development and Malaria Treatment and Local and Regional Organizations. The Atlantic Vaccines & Immunotherapeutics Summit, Bethesda, Maryland, May 2015.

23. Panel Moderator, The Myanmar National Plan. Conference on Malaria Elimination in Myanmar, convened by the Institute for Global Health (IGH) at the University of Maryland School of Medicine, the Center for Strategic and International Studies (CSIS), and the American Society of Tropical Medicine & Hygiene (ASTMH), Washington, DC, August 2015.

24. The School of Medicine’s role in global health: Ending malaria. Mini-Medical School, University of Maryland School of Medicine, Baltimore, Maryland, October 2015.

25. Global health in war and peace, University of Maryland Baltimore County, Guest Lecture, Department of Sociology and Anthropology, Baltimore, Maryland, November 2015.

26. Drug resistant malaria: using genomic epidemiology & population genetics to guide malaria elimination. Johns Hopkins Bloomberg School of Public Health, Malariology, Baltimore, Maryland, March 2016.

27. Global health in war and peace: A case for global health diplomacy. Think Global lecture series, Duke

Global Health Institute, Duke University, Durham, North Carolina, September 2018. 28. Eradicating human diseases: opportunities and risks. Panel, Duke at Home in the World, Duke

University, Durham North Carolina, November 2018. 29. Strategic partnerships in global health, 14th Annual Center for AIDS Research Retreat, Duke University,

Durham, North Carolina, September 2018. 30. Achieving the health SDGs. Panel moderator, Duke Conference on International Development, The

New Building Blocks of Development, Duke University, Durham North Carolina, November 2018.

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31. Global health in war and peace: A case for global health diplomacy. Institute for Global Health & Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, November 2018.

National

1. Video imaging of emergence & exflagellation of Plasmodium falciparum sexual stages. 41st Annual Meeting of The American Society of Tropical Medicine & Hygiene, Seattle, November 1992. (Video also excerpted on television series ARCHEOLOGY, episode “A Roman Plague”, broadcast on The Learning Channel, October 1995).

2. Epidemiology of drug-resistant malaria: Impact of treatment policies and drug availability. Keystone Symposium on the Molecular Basis for Drug Resistance in Bacteria, Parasites and Fungi, Park City, Utah, March 1996.

3. Molecular and epidemiologic mapping of antifolate resistant Plasmodium falciparum. International Workshop on Molecular Epidemiology and Evolutionary Genetics of Pathogenic Microorganisms, Centers for Disease Control and Prevention, Atlanta, Georgia, June 1996.

4. Molecular epidemiology of antifolate resistant malaria. Symposium: How to manage the resistance developing to Fansidar. 46th Annual Meeting of the American Society of Tropical Medicine & Hygiene, Orlando, Florida, December 1997.

5. Antifolate resistant malaria: Molecular mechanisms, epidemiology and control strategies. Symposium: Malaria Chemotherapy. 46th Annual Meeting of the American Society of Tropical Medicine & Hygiene, Orlando, Florida, December 1997.

8. Genetic heterogeneity and drug resistance. Malaria Genome Meeting, Washington DC, December 1999.

9. A molecular marker for chloroquine resistant falciparum malaria. Division of Infectious Diseases, University of California, San Francisco, California, July 2000.

10. Clearance of drug-resistant parasites as a model for protective immunity in falciparum malaria. Division of Geographic Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, November 2000.

11. A molecular marker for chloroquine-resistant falciparum malaria. Division of Microbiology & Immunology MCP Hahnemann University School of Medicine, Philadelphia, Pennsylvania, November 2000.

12. International biomedical research: Perspectives from a U.S. investigator working in Africa. Annual Retreat, Division of Extramural Affairs, National Institutes of Health, Bethesda, Maryland, October 2000.

13. Application of a molecular marker for surveillance of chloroquine-resistant falciparum malaria. NIAID International Centers for Tropical Disease Research Network, Tenth Anniversary Meeting, National Institutes of Health, Bethesda, Maryland, May 2001.

14. Biomedical ethics in the real world: Perspective from a U.S. investigator working in Africa. International Training in Emerging and Infectious Diseases Annual Directors’ Meeting, Fogarty International Center, National Institutes of Health, Bethesda, Maryland, May 2001.

15. Malaria. 13th Annual Symposium on Frontiers of Science, National Academy of Sciences, Irvine, California, November 2001.

16. International Research Ethics. Meet the Professor session, 50th Annual Meeting of the American Society of Tropical Medicine & Hygiene, Atlanta, Georgia, November 2001.

25

17. A practical model for using molecular markers to monitor chloroquine- and sulfadoxine-pyrimethamine resistant falciparum malaria in sub-Saharan Africa. Plenary speaker, 50th Annual Meeting of the American Society of Tropical Medicine & Hygiene, Atlanta, Georgia, November 2001.

18. Monitoring antimalarial drug resistance: Making the most of the tools at hand. Speaker and Symposium Chair, Anti-Malarial Drugs. 52nd Annual Meeting of the American Society of Tropical Medicine & Hygiene, December 2003.

19. Antimalarial drug treatment in Africa: Is what’s good for the goose good for the gander? Pediatric Grand Rounds, Vanderbilt University School of Medicine, Nashville, Tennessee, May 2004.

20. Antimalarial drug resistance in Africa: Strategies for monitoring and deterrence. New York Academy of Science, New York, New York, April 2005.

21. Drug resistant malaria: Mechanisms, surveillance and strategies for deterrence. Division of Infectious Diseases, New York University, New York, New York, October 2005.

22. The use of longitudinal study design for the assessment of antimalarial drug efficacy. Keynote Speaker, Medicines for Malaria Venture/NIAID Meeting on the Design of Phase III Clinical Trials for Malaria, Bethesda, Maryland, December 2005.

23. Benjamin H. Kean Memorial Lecture: Malaria. Cornell University Medical College, New York, New York, March 2006.

24. Genetic diversity and malaria vaccine efficacy. Department of Medical Parasitology, New York University, New York, New York, March 2006.

25. Genetic diversity of Plasmodium falciparum malaria vaccine antigens MSP-1 and AMA-1 at a malaria vaccine trial site in Mali. Division of Microbiology and Infectious Disease International Research in infectious Diseases Meeting, Bethesda, Maryland, May 2006.

26. Return of chloroquine anti-malarial efficacy in Malawi. Division of Microbiology and Infectious Disease International Research in Infectious Diseases Meeting, Bethesda, Maryland, May 2006.

27. Application of genetic diversity to human infection with Plasmodium falciparum. Symposium: Malaria Genetic Diversity. 56th Annual Meeting of the American Society of Tropical Medicine & Hygiene, Philadelphia, Pennsylvania, November 2007.

28. The role of molecular markers in surveillance for antimalarial drug efficacy. Symposium: World Antimalarial Resistance Network: Steps to Implementation. 56th Annual Meeting of the American Society of Tropical Medicine & Hygiene, Philadelphia, Pennsylvania, November 2007.

29. Genetic diversity and drug-resistant malaria. Symposium: Bridging Pathogenesis and Pathology in Malaria: Addressing Drug Resistance and Tolerance in Malaria Parasites. 56th Annual Meeting of the American Society of Tropical Medicine & Hygiene, Philadelphia, Pennsylvania, November 2007.

30. Malaria vaccines. New York Academy of Sciences, New York, New York, December 2007.

31. Drug resistant malaria. St. Jude/PIDS Pediatric Infectious Diseases Research Conference, Memphis, Tennessee, February 2008.

32. Toward malaria eradication: Research and development frontiers. Malaria Day, Capitol Hill, Washington DC, April 2008.

33. Resistance to malaria drugs. Resources for the Future Consultative Forum on the Affordable Medicines Facility- malaria (AMFm), Washington DC, September 2008.

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34. The evolution of drug-resistant malaria. Howard Hughes Medical Institute/National Institutes of Health Research Scholars Meeting, Bethesda, Maryland, October 2008.

35. Genetic diversity and blood-stage malaria vaccine efficacy: Overcoming vaccine resistant malaria. Doris Duke Charitable Foundation Clinical Scientist Meeting, Newport, Rhode Island, October 2008.

36. Antimalarial resistance monitoring: Using surveillance to inform decisions. Symposium: Global Strategies for Using Antimalarial Drugs: Making the Most of a Precious Resource. 57th Annual Meeting of the American Society of Tropical Medicine & Hygiene, New Orleans, Louisiana, December 2008.

37. The evolution of drug-resistant malaria. University of Pennsylvania Institute for Translational Medicine and Therapeutics Seminar, Philadelphia, Pennsylvania, January 2009.

38. Clinical research through the R34 – U01 process. National Institute of Allergy and Infectious Diseases Consultation on Developing Clinical Research Infrastructure for Infectious Diseases, Bethesda, Maryland, July 2009.

39. Defining the knowledge gap: Vaccines and drugs. 58th Annual Meeting of the American Society of Tropical Medicine & Hygiene, Washington DC, November 2009.

40. Malaria Eradication. 14th International Congress on Infectious Diseases, Miami, Florida, March 2010.

41. Global Health: Can we eradicate malaria? Critical Unsolved Problems in BioMedicine: Michael Bishop Symposium, University of California, San Francisco, June 2010.

42. Vaccine Resistant Malaria. Yale School of Public Health Epidemiology of Microbial Diseases Seminar, New Haven, Connecticut, March 2011.

43. Molecular and immune correlates of protection by a blood stage malaria vaccine. Division of Microbiology and Infectious Disease International Research in Infectious Diseases Meeting, Bethesda, Maryland, May 2011.

44. A malaria vaccine: How close are we? The New York Academy of Sciences Malaria Symposium: Drugs, Vaccines and Pathogenesis, New York, New York, April 2012.

45. A genome-wide association study of the genetic basis of resistance to artemisinin treatment of clinical Falciparum malaria in Southeast Asia. Translational Medicine Science Meeting, Howard Hughes Medical Institute Janelia Farm Research Campus, Ashburn, Virginia, April 2012.

46. New Blood Stage Concepts: Molecular and Immune Correlates of Strain-Specific Efficacy. NIAID Workshop, Rockville, Maryland, June 2012.

47. Drug Resistant Malaria. Keynote Speaker, Meeting the Challenges of Rare Disease Drug Review, U.S. Food and Drug Administration. Silver Spring, Maryland, April 2013.

48. Progress towards identification of artemisinin resistance molecular markers. Symposium: Mapping Artemisinin Resistance in the Mekong Region. 61st Annual Meeting of the American Society of Tropical Medicine & Hygiene meeting, Atlanta Georgia, November 2012.

49. New additions to the toolbox for global malaria eradication. The Jeremiah Metzger Lecture, 126th Meeting of the American Clinical and Climatological Association, Charleston, South Carolina, October 2013.

50. Malaria eradication: Prospects, pitfalls and new tools. 51st Annual William J. Holloway Infectious Disease Symposium, Christiana Health Care, Newark, Delaware, May 2014.

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51. Malaria elimination and drug resistance containment in Asia. Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, DC, September 2014.

52. Malaria vaccines. Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, DC, September 2014.

53. Panels: Evolving Technologies in the Push for Elimination; The Threat of Artemisinin and Pyrethroid Resistance. A Strategic Approach to Malaria, Center for Strategic and International Studies (CSIS), Washington, DC, December 2014. Videos available at: http://csis.org/multimedia/strategic-approach-malaria-interview-dr-plowe; http://csis.org/event/strategic-approach-malaria

54. Applying Genomics to Malaria Elimination. Gordon Research Conference, Galveston, Texas, March 2015.

55. Panel Moderator, The Myanmar National Plan. Conference on Malaria Elimination in Myanmar, convened by the Institute for Global Health at the University of Maryland School of Medicine, the Center for Strategic and International Studies, and the American Society of Tropical Medicine & Hygiene, Washington, DC, August 2015.

56. Jumping and popping resistance: Mapping malaria parasite networks and migration patterns in Myanmar. Symposium: Political Will and New tools for National Malaria Elimination in Myanmar. 64th Annual Meeting of the American Society of Tropical Medicine & Hygiene, Philadelphia, Pennsylvania, October 2015.

57. Tropical medicine in war and peace. Presidential Address, 64th Annual Meeting of the American Society of Tropical Medicine & Hygiene, Philadelphia, Pennsylvania, October 2015.

58. International Collaborations in Infectious Disease Research (ICIDR): Answering questions relevant to lower-income countries. 7th Annual Consortium of Universities for Global Health (CUGH) Conference, San Francisco, California, April 2016.

59. Fulfilling the legacy and vision of Alan Magill: Malaria Delenda Est. Alan Magill Malaria Symposium, Walter Reed Army Institute of Research, Silver Spring, Maryland, June 2016.

International

1. Molecular Assays for Drug-Resistant Malaria. Kenya Medical Research Institute/Wellcome Trust Research Laboratories, Kilifi, Kenya, July 1993.

2. Polymerase Chain Reaction (PCR): Une Technique pour la Detection des Parasites du Paludisme Resistant aux Antifolates. Malaria Research & Training Program, National School of Medicine & Pharmacy, Bamako, Mali, August 1993.

3. Pyrimethamine resistance mutations and community antimalarial drug use patterns in Mali. Institute of Molecular Medicine, Oxford University, United Kingdom, August 1994.

4. The selective effect of antifolate drug use on resistance-conferring mutations in P. falciparum dihydrofolate reductase. Department of Biochemistry and Applied Molecular Biology, University of Manchester Institute of Science and Technology, Manchester, United Kingdom, August 1994.

5. Bases moléculaires de la résistance à la sulfadoxine-pyriméthamine: Intérêt épidémiologique d’une technique de PCR. The First Scientific Congress of the African Society of Microbiology, Bamako, Mali, January 1996.

6. Epidemiology of drug resistant malaria: Impact of treatment policies and drug use. Malaria Research and Training Center, University of Mali, April 1996.

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7. Molecular epidemiology of drug-resistant malaria. 2nd International Workshop on Molecular Epidemiology and Evolutionary Genetics of Pathogenic Microorganisms, ORSTOM/CNRS, Montpellier, France, May 1997.

8. Molecular assays for drug-resistant malaria. Second Global Meet on Parasitic Diseases, Hyderabad, India, August 1997.

9. Drug-resistant malaria. Medical Grand Rounds, Queen Elizabeth Central Hospital and University of Malawi School of Medicine, Blantyre, Malawi, February 1998.

10. Molecular markers for drug-resistant malaria. Plenary speaker, Gordon Research Conference on Malaria, Somerville College, University of Oxford, United Kingdom, July 1998.

11. Molecular mechanisms of drug-resistant malaria: New tools for surveillance? XXV Annual Meeting on Basic Research in Chagas Disease & XIV Meeting of Brazilian Society of Protozoology, Caxambu, Brazil, November 1998.

12. Development of malaria trials: The Mali experience. U.S. / European Commission Workshop on Curriculum Development for Clinical Trials Monitoring, Veyrier-du-Lac, France, March 1999.

13. In vivo chloroquine responses and Pfcrt polymorphisms in Bandiagara, Mali. (Speaker and session organizer) 4th International Meeting on Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases, Dakar, Senegal, June 1999.

14. Potential for trimethoprim-sulfamethoxazole to facilitate Fansidar-resistant malaria. The second conference on Global Strategies for the Prevention of HIV Transmission from Mothers to Infants, Montreal, Canada, September 1999.

15. Malaria, the growing problem of drug resistance. Plenary speaker, Swiss Society of Tropical Medicine Parasitology, Annual Congress, Solothurn, Switzerland, November 1999.

16. Drug resistant malaria. Department of Medical Biochemistry, University of Stellenbosch Medical School, Cape Town, South Africa, November 1999.

17. Update on molecular markers for drug-resistant malaria: Implementation and implications for clinical immunity. Invited speaker, Gordon Research Conference on Malaria, Queen’s College, Oxford, United Kingdom, August 2001.

18. Monitoring antimalarial drug resistance: Making the most of the tools at hand. Quinto Simposio de Investigaciones en Salud, Escuela de Salud Publica, Universidad del Valle, Cali, Colombia, October 2003.

19. Antimalarial drug treatment in Africa: Is what’s good for the goose good for he gander? Annual Scientific Meeting of the Wellcome Trust Tropical Centre, Zomba, Malawi, October 2004.

20. Dynamics of P. falciparum sensitivity to chloroquine and sulfadoxine-pyrimethamine during 7 years of sentinel site surveillance in Bandiagara, Mali. Medicine and Health in the Tropics, Marseille, France, September 2005.

21. Assessing antimalarial efficacy in Africa: Longitudinal trials as a public health tool. 4th Multilateral Initiative on Malaria Pan-African Malaria Conference, Yaounde, Cameroon, November 2005.

22. Clinical efficacy of chloroquine in Malawi in 2005. Malaria Alert Centre, University of Malawi College of Medicine, April 2006.

23. Assessing treatment efficacy in vivo: What should we follow? 12th International Society for Infectious Diseases meeting, Lisbon, Portugal, June 2006.

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24. Antimalarial resistance and how it’s affecting therapeutic strategies. IDSA/ICAAC Joint Symposium: Susceptibility, Infectious Diseases Society of America 44th Annual Meeting, Toronto, Canada, October 2006.

25. Genetic diversity and malaria drug and vaccine efficacy. Malaria Parasite Diversity Meeting, Wellcome Trust Sanger Institute, Hinxton, United Kingdom, January 2007.

26. Drugs and resistance. Antimalarial Treatment Strategies: Getting the Most from Malaria Drugs, Kruger National Park, South Africa, April 2008.

27. Artemisinin resistance? Confirmation, characterization, containment (ARC3). 2008 Next Steps for Plasmodium Post-Genomic Research: A Strategy Meeting, London, United Kingdom, April 2008.

28. Genetic diversity and malaria vaccine efficacy. 2008 Next Steps for Plasmodium Post-Genomic Research: A Strategy Meeting, London, United Kingdom, April 2008.

29. Public health application of Plasmodium genomics: Drug resistance markers. Genomic Epidemiology of Malaria, Wellcome Trust Sanger Institute, Hinxton, United Kingdom, June 2008.

30. The evolution of drug-resistant malaria. Annual Scientific Meeting of the Wellcome Trust Tropical Centre, Liverpool University, Liverpool, United Kingdom, September 2008.

31. Defining the genotype of artesunate resistance. World Health Organization ARC3 Investigators’ Meeting, Bangkok, Thailand, September 2009.

32. Defining the knowledge gaps: Tools. 5th Multilateral Initiative on Malaria Pan African Malaria Conference, Nairobi, Kenya, November 2009.

33. Update in the global effort to identify artemisinin resistance markers. Genomic Epidemiology of Malaria, Wellcome Trust Sanger Institute, Hinxton, United Kingdom, June 2010.

34. Genetic diversity and malaria drug and vaccine efficacy. Frontiers in Genomics, National University of México, Campus Cuernavaca, Mexico, September 2010.

35. Progress on Drug Resistant Malaria: Use of Genomics to Identify Artemisinin Resistance Markers. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China, February 2011.

36. Putting the malaria genome to good use. Opening Plenary Lecture, Genomic Epidemiology of Malaria, Wellcome Trust Sanger Institute, Hinxton, United Kingdom, June 2011.

37. Genomic analysis of P. falciparum diversity: Implications for vaccine development. 2012 Grand Challenges Meeting, Ottawa, Canada, December 2012.

38. Malaria vaccines: Update. Department of Medical Research-Lower Myanmar, Yangon, Myanmar, September 2013.

39. Malaria. Continuing Medical Education lecture for Myanmar Medical Association, Yangon, Myanmar, September 2013.

40. A case study of the benefits of research for public health: Malaria elimination in the Greater Mekong Sub-region. 5th International Conference on Public Health among Greater Mekong Sub-region Countries, Yangon, Myanmar, September 2013.

41. The role of vaccines in malaria elimination. Symposium: The role of vaccines in malaria elimination, 6th Multilateral Initiative on Malaria Pan-African Malaria Conference “Moving towards malaria elimination: Investing in research and control”, Durban, South Africa, October 2013.

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42. The Great Malaria Debate: Elimination of artemisinin-resistant malaria from Southeast Asia – is it possible? Joint International Tropical Medicine Meeting, Bangkok, Thailand, December 2013.

43. New tools for the surveillance of malaria in Myanmar. Department of Medical Research-Lower Myanmar, Yangon, Myanmar, February 2014.

44. The molecular basis of artemisinin resistant malaria. Delaying Artemisinin Resistance in India: A Consultation Convened by the Public Health Foundation of India and National Institute of Malaria Research, Delhi, India, March 2014.

45. New tools for malaria elimination in Myanmar. 22nd Myanmar Military Medical Conference, Yangon, Myanmar, February 2015.

46. Molecular surveillance for malaria elimination in Myanmar. Emerging Infectious Diseases: Current Practices and Strategic Approaches to Future Challenges, Defence Services Medical Research Center, Nay Pyi Taw, Myanmar, February 2015.

47. New tools for malaria elimination. 23rd Myanmar Military Medical conference, Yangon, Myanmar, February 2016.

48. New progress for artemisinin resistance surveillance in Asia. 3rd Symposium on Surveillance Response System Leading to Tropical Diseases Elimination, Shanghai, P.R.C., June 2016.

49. Drug resistant malaria - emergence, selection, spread: Global health implications. 7th Multilateral

Initiative on Malaria Conference, Dakar, Senegal, April 2018. 50. Molecular prevalence of malaria in Myanmar and neighboring regions in Bangladesh and China.

Genomic Epidemiology of Malaria 2018, Hinxton, United Kingdom, June 2018. 51. Drug resistant malaria - emergence, selection, spread: Global health implications. Institut für

Tropenmedizin, University of Tübingen, Tübingen, Germany, June 2018. 52. Drug resistant malaria - emergence, selection, spread: Global health implications. Kilimanjaro Christian

Medical College, Moshe, Tanzania, June 2018.

Administrative Service:

Institutional Service

1995 - 1999 Head, Molecular Parasitology and Malaria Field Studies Unit Center for Vaccine Development, University of Maryland School of Medicine

1999 - 2010 Chief, Malaria Section, Center for Vaccine Development University of Maryland School of Medicine

2000 - 2003 Research Advisory Committee University of Maryland School of Medicine 2005 – 2010 Global Health Multidisciplinary Research Committee University of Maryland Baltimore

2005 – 2010 Global Health Educational Committee University of Maryland Baltimore

31

2009 Subcommittee on Individualizing the Curriculum, Part of the new Education Roadmap University of Maryland School of Medicine

2010 Faculty Excellence Recognition and Awards Committee University of Maryland School of Medicine

2010 – 2015 Leader, Malaria Group, Center for Vaccine Development University of Maryland School of Medicine

2010 – 2015 Associate Director for Research Training, Center for Vaccine Development University of Maryland School of Medicine

2015 Interim Director, Center for Vaccine Development University of Maryland School of Medicine

2015 – 2016 Chief, Division of Geographic Medicine, Department of Medicine University of Maryland School of Medicine

2015 – 2017 Founding Director, Institute for Global Health Director, Division of Malaria Research University of Maryland School of Medicine

2018 – present Director, Duke Global Health Institute

Local Service

1990 Volunteer Physician, New York City Marathon

1992 Organizer, Combined Malaria Seminar, Bethesda, Maryland

1994 Volunteer Physician, Washington Free Clinic, Washington D.C.

2001 – 2003 Board Member, Tropical Medicine Dinner Club of Baltimore

2010 Panel Member, Commercial Opportunities for Global Health TechCouncil of Maryland

National and International Service

1983 - 1985 Member, Cornell University Board of Trustees

1994 - 1996, 2001 2003 - 2005 2013 - 2014 Expert consultant to law firms on malpractice cases involving malaria

1995 - present Reviewer of manuscripts for scientific journals including: Science, Nature, New England Journal of Medicine, Lancet, Proceedings of the National Academy of Sciences USA, PLoS Medicine, Journal of Clinical Investigation, Journal of Infectious Diseases, Clinical Infectious Diseases, Annals of Internal Medicine, American Journal of Epidemiology, Journal of Clinical Microbiology, Experimental Parasitology, Journal of Parasitology, Epidemiologic Reviews, Antimicrobial Agents and Chemotherapy, American Journal of Tropical Medicine & Hygiene, Trends in Parasitology, Drug Resistance Updates, Infection and Immunity, Annals of Tropical Medicine and Parasitology, Malaria Journal

32

1997 - 2004 Expert consultant to International Atomic Energy Agency, Division on Human Health, Regional Program on Malaria Control in Africa, to transfer technology for molecular diagnosis of drug-resistant malaria to laboratories in Africa

1997 - 2009 Founding Chairman, Benjamin H. Kean Traveling Fellowship Committee, American Society of Tropical Medicine & Hygiene

1997 Member, Advisory group on establishment of Malaria Research Reference and Reagent Resource, NIAID

1997 Grant reviewer, Department of Veterans Affairs, Merit Review

1998 Member, NIAID Special Emphasis Panel for review of RFA “Human Immune Resistance to Malaria in Endemic Areas”

1998 Member, NIAID Special Emphasis Panel for review of RFA “Tropical Diseases Research Units”

1998 Grant reviewer, Conservation, Food & Health Foundation, Inc.

1998 Reviewer, Wellcome Trust, Wellcome Research Training Fellowship in Tropical Medicine

1999 Grant reviewer, UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases / Multilateral Initiative on Malaria Task Force on Malaria Research Capability Strengthening in Africa grant

1999 Technical Advisor, Meeting on Markers of Antimalarial Drug Resistance World Health Organization

1999 Technical advisor on malaria research priorities, USAID Bureau for Africa

1999, 2002 Ad hoc reviewer, NIAID study section, Tropical Medicine & Parasitology

1999 - 2003 Councilor, American Society of Tropical Medicine & Hygiene

1999 Reviewer, Wellcome Trust International Research Development Award

2000 Panelist on Ethical Issues in International Health Research President’s National Bioethics Advisory Commission

2000 Joint UNAIDS/WHO Consultation on Prophylactic Use of Cotrimoxazole to Prevent Opportunistic Infections among People Living With HIV/AIDS in Africa, Harare, Zimbabwe

2000 - 2006 Editorial Board, Infection and Immunity

2000 - 2008 Scientific Program Committee American Society of Tropical Medicine & Hygiene

2001 Expert witness testimony on behalf of American Society of Tropical Medicine & Hygiene for Committee on Appropriations, Subcommittee on Labor, Health and Human Services, Education, and Related Agencies, United States House of Representatives

2001 Consultation on Monitoring Resistance to Antimalarial Drugs World Health Organization

33

2002 International Planning Workshop for the FY 2004 NIH Plan for HIV-Related Research, National Institute of Allergy and Infectious Diseases

2002 Meeting on Tuberculosis, AIDS and Equity, National Tuberculosis Control Programme, Lilongwe, Malawi

2002 – 2006 Member, Scientific Advisory Committee, Malaria Research and Reference Resource Center (MR4), American Type Culture Collection

2002, 2003 Grant reviewer, Wellcome Trust Tropical Medicine Programme

2003 Scientific Review Panel, Malaria in Pregnancy Consortium Bill & Melinda Gates Foundation, London, UK

2003 Consultation on the Goal of Antimalarial Treatment Policy in the WHO Africa Region, Harare, Zimbabwe

2003 Grant Reviewer, AAAS Women’s International Science Collaboration Program

2003 - 2005 Nominations Committee, American Society of Tropical Medicine & Hygiene

2004 Grant Reviewer, Wellcome Trust Career Development Fellowship in Clinical Tropical Medicine

2005 Ad hoc member, National Institute of Allergy and Infectious Diseases, Microbiology and Infectious Diseases Review Committee, Institutional National Research Service Award Research Training Grants and Career Development/Research Career Development (K) Awards

2005 Special Emphasis Panel, National Institute of Allergy and Infectious Diseases Loan Repayment Program

2005 Burroughs Wellcome Fund Next steps for malaria research: Where are we going in the post-genomic era? Broad Institute, Cambridge, MA

2005 Expert Consultation on Co-Trimoxazole Prophylaxis in HIV infection World Health Organization, Geneva

2005 Consultation on the Use of Sulfadoxine-Pyrimethamine for Intermittent Preventive Therapy During Pregnancy in Areas of Moderate to High SP Resistance, World Health Organization-AFRO, Harare, Zimbabwe

2006 – 2011 Editorial Advisory Board, Journal of Infectious Diseases

2006 - 2008 Plasmodium falciparum Haplotype Map Advisory Committee Broad Institute of MIT and Harvard

2006 World Health Organization Working Group on Measures of Malaria Vaccine Efficacy, Montreux, Switzerland

2007 Special Emphasis Panel, National Institute of Allergy and Infectious Diseases NIAID Clinical Trial Planning (R34) Grants

2008 - 2009 Vice Chair, Board of Directors Worldwide Antimalarial Resistance Network (WWARN)

2008 - 2014 Head, Molecular Module, Worldwide Antimalarial Resistance Network (WWARN)

34

2008 Study Committee on Intermittent Preventive Therapy for Malaria in Infants Board on Global Health, Institute of Medicine of the National Academies

2008 - 2009 International Scientific Committee and Session Chair, Multilateral Initiative on Malaria 5th Pan-African Malaria Conference, Nairobi, Kenya

2008 - 2010 Chair, Drugs Consultative Group and Member, Steering Committee and Vaccines Consultative Group, Malaria Eradication Research Agenda (malERA)

2008 - 2009 Scientific Advisory Panel, Doris Duke Charitable Foundation Clinical Scientist Development Award

2008 Malaria Disease Scientific Advisory Board, FasterCures Philanthropy Advisory Service, Milken Institute

2009 Expert Consultant, World Health Organization Initiative for Vaccine Research, Scientific Forum: Progress and Challenges with Whole-Organism Malaria Vaccines, Dakar, Senegal

2009 Technical Advisor, World Health Organization Meeting: Define and Validate the Protective Efficacy of SP-IPTi, Geneva, Switzerland

2009 Consultation on Developing Clinical Infrastructure for Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID)

2010 Chair, NIH/FIC Conference on Artemisinin Resistant Malaria: Research Challenges, Opportunities, and Public Health Implications

2012 - present Member, Technical Expert Group on Drug Resistance and Containment, Global Programme on Malaria, World Health Organization (WHO)

2012 - 2015 KAE609 Advisory Board, Novartis Pharma AG

2013 – 2015 Consultant, Provide Scientific Advice on Development in the Field of Malaria, Novartis Pharma AG

2013 Informal Consultation on Operational Research to Support Accelerating Malaria Elimination in the Context of Artemisinin Resistant Falciparum Malaria in the Greater Mekong Sub-Region, Bangkok, Thailand

2014 Delaying Artemisinin Resistance in India, a Consultation Convened by the Public Health Foundation of India and National Institute of Malaria Research, Delhi, India

2014 Expert Review Group on K13, World Health Organization (WHO)

2016 WHO Expert Consultation on Adoption and Operationalization of WHO Global Policies, Guidance and Strategies in Malaria in the South-East Asia Region and the Greater Mekong Sub-region, WHO SEARO, New Delhi, India

2016 CDC Foundation Expert Panel on Addressing Multidrug-Resistant TB, Artemisinin-Resistant Malaria, and Increasing Vaccine Use: Opportunities for Global Action and Approaches on Antimicrobial Resistance, New York, New York

2016 WHO Global Malaria Programme Expert Review Group on the Emergence and Spread of multidrug resistant P. falciparum lineages in the Greater Mekong Sub-Region, Geneva, Switzerland

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2018 - present Member, Scientific Advisory Board, Johns Hopkins Malaria Research Institute,

Baltimore, Maryland 2018 - present Member, Scientific Advisory Council, Medical Research Program, Doris Duke Charitable

Foundation, New York, New York

Teaching Service:

University of Maryland School of Medicine 1995 Tropical Medicine and International Health, Course for 3rd & 4th year students. Course organizer and lecturer. Student contact time: 10 hours/week x 4 weeks/year.

1996 summer Research elective supervisor for 4th year medical student Mark Landrum.

1996 - 2005 Small group leader for Infectious Diseases section of Host Defenses & Infectious Diseases course for 15-20 medical students. Student contact time: 3 hours/year.

1996 - present Research supervisor for visiting fellows from Brazil (1) Colombia (2), China (1), Kenya (1), Mali (13), Malawi (3), Myanmar (1), Pakistan (1), Tanzania (2), Thailand (2), Uganda (1), Venezuela (1) for six weeks to one year each.

1996 - 2005, 2007- Lecturer for parasitology block in Host Defenses & 2008 Infectious Diseases course for ~150 medical students. Student contact time: 2 hours/week x 1 week/year.

1996 - present Small group leader for parasitology block in Host Defenses & Infectious Diseases course for ~150 medical students. Student contact time: 2 hours/week x 1weeks/year.

1997 – 2010 Malaria lecture, Board Review Course for Infectious Diseases Fellows.

1996 - 2002 Clinical supervision and teaching of 1-3 medical students, 1-2 medical residents, 0-2 pharmacy students and residents, and 1-2 infectious diseases fellows. Contact time, 20 hours/week, 2 months/year. (2 weeks/year in 2002).

1997 - 2002 Ph.D. thesis supervisor for Abdoulaye Djimde in Microbiology & Immunology, Mentor for NIH career development award

1998 - 2001 Research supervisor for research fellow James Kublin, M.D., M.P.H. Mentor for NIH K01 Career Development Award

1998-present Malaria Vaccines lecture, Vaccinology Course, Center for Vaccine (biennially) Development/Department of Epidemiology & Preventive Medicine. 20-30 graduate students, fellows, & staff. Contact time 1 hour/year.

1998 - 1999 Research supervisor for Masters degree student Victoria Kioko

1999 summer Research supervisor for visiting medical student Andrew Cole

1999 - 2001 Research supervisor for MSc student Jayasree Iyer Department of Microbiology & Immunology

1999 - 2006 Supervisor for clinical and research fellow Kirsten Lyke, M.D. Mentor for NIH K23 Career Development Award

36

1999 - 2002 Supervisor for clinical and research fellow Paul Sehdev, M.D.

2001 Supervisor for Preventive Medicine Resident Ely Mouchahoir, M.D.

2002 - 2004 Ph.D. dissertation committee member for Rhoel Dinglasan, Department of Microbiology & Immunology

2002 - 2004 Ph.D. advisor for Modesta Ndejembi Department of Microbiology & Immunology

2002 - 2006 Ph.D. advisor and committee co-chair for Shannon Takala, Molecular Epidemiology Track Department of Epidemiology and Preventive Medicine

2002 - 2004 Research supervisor for Miriam Laufer, M.D., mentor for NIH K23 Career Development Award

2003 - 2006 Research supervisor for Lorraine Beraho, Meyerhoff Scholar, Howard Hughes Medical Institute Scholar, UMBC undergraduate (full-time Summer 2003; part-time through 2006)

2003 - 2005 Research supervisor for Aric Gregson, M.D., Vaccinology Fellow, Center for Vaccine Development

2004 - 2006 Research supervisor for Jason Nixon NIH Fogarty International Clinical Research Scholar

2004 - 2007 Research supervisor for Phillip Thesing, D.O., post-doctoral fellow

2004 - 2006 Research supervisor for Craig Conard, NIH Fogarty International Clinical Research Scholar

2005 - 2009 Ph.D. dissertation committee member for Calvin Williams, Department of Microbiology and Immunology

2005 - 2009 Ph.D. dissertation committee member for Saranath Lawpoolsri, Department of Epidemiology and Preventive Medicine

2005 - 2012 Research supervisor for Amed Ouattara, Pharm.D., doctoral student in Molecular Epidemiology

2005 - 2008 Research supervisor for Matthew Laurens, M.D., M.P.H., Vaccinology Fellow, Center for Vaccine Development

2006 - 2016 Lecturer, Global Health: Critical Issues (PREV664)

2006 - 2008 Research supervisor for Amber Gaither, Meyerhoff Scholar, Howard Hughes Medical Institute Scholar UMBC undergraduate (part- time)

2006 - 2011 Research supervisor for Kavita Gandhi, graduate student in Molecular Epidemiology

2007 Research supervisor for University of Maryland medical students Katie Bever, Sarah Edekin-Weyer, Nidhi Goel, Robin Goldman, Doris Duke Malaria Research Fellows (Malawi, Mali)

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2007 - 2008 Research supervisor for Breanna Barger NIH Fogarty International Clinical Research Scholar

2007 - 2008 Research supervisor for Chuka Didigu Villa Julie College undergraduate (part-time)

2008 Research supervisor for University of Maryland medical students Aaron Hess, Andrea Hebert, Ravindra Gopaul, Marie Shockley, Doris Duke Malaria Research Fellows (Malawi, Mali)

2008 - 2009 Research supervisor for Jessica Manning, NIH Fogarty International Clinical Research Scholar

2008 - 2011 Research supervisor for Anissa Alexander Meyerhoff Scholar, Howard Hughes Medical Institute Scholar, Ventures Scholar, UMBC undergraduate student in Biomedical Science (full-time Summer 2008; part-time otherwise)

2008 Research supervisor for Sarah Sauthoff, Villa Julie College undergraduate (part-time)

2008 - 2010 Research supervisor for Mark Travassos, M.D., M.Sc., Vaccinology Fellow, Center for Vaccine Development

2007 - 2009 Research supervisor for Andrea Berry, M.D., Vaccinology Fellow, Center for Vaccine Development

2008 - 2011 Research supervisor for Meera Venkatesan, Ph.D., Postdoctoral Fellow, Center for Vaccine Development

2009 Research supervisor for University of Maryland medical students Leah Couture, Elizabeth Gillenwater, Elizabeth Gilliams, Adam Martin, Doris Duke Malaria Research Fellows (Malawi, Mali)

2009 Research supervisor for Shani Weerakoon, Howard Hughes Summer Research Intern

2009 - 2010 Research supervisor for Ako Berenger, Robert S. MacNamara Fellow

2009 - 2010 Research supervisor for Anastasia Grivoyannis, NIH Fogarty International Clinical Research Scholar

2009 - 2010 Research supervisor for Anne Frosch, M.D., M.P.H., Vaccinology Fellow, Center for Vaccine Development

2009 - 2010 Research supervisor for Amelia Maiga NIH Fogarty International Clinical Research Scholar

2010 Research supervisor for University of Maryland medical students Adam Kalwerisky, Matthew Pierce, Robert Sellke, Jennifer Silber, Doris Weyinshet Gossa, Abbey Masonbrink, Adam Martin, Doris Duke Malaria Research Fellows (Malawi, Mali)

2010 Research supervisor for Kristin Boulier Johns Hopkins University undergraduate (summer)

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2010 Research supervisor for Atheeth Hiremath, Meyerhoff Scholar, UMBC undergraduate student in Biochemistry & Molecular Biology (part-time)

2010 - 2015 Research supervisor for Jason Bailey, doctoral student in Molecular Epidemiology

2010 - 2015 Research co-supervisor for Elena Artimovich, doctoral student in Human Genetics and Genomic Epidemiology

2010 - 2015 Research supervisor for Christopher Jacob, doctoral student in Molecular Genetics, Genomics, and Bioinformatics

2011 Research supervisor for Gabriel Rangel, HHMI Exceptional Research Opportunities Program participant, Purdue University undergraduate student in Biochemistry (summer)

2011 Research supervisor for Grace Maldarelli, MD PhD student in Molecular Epidemiology (rotation)

2011 Research supervisor for University of Maryland medical students Elizabeth Allan, Sarah Boudova, Erin Haser, Rachel Koch, Jessica Moskowitz, Rachel Shuck, Doris Duke Malaria Research Fellows (Malawi, Mali)

2011 Research supervisor for Kenneth Wayman, Mcdonogh High School

2011 - 2012 Research supervisor for Leo Kenefic, Ph.D., Postdoctoral Fellow, Center for Vaccine Development Malaria Group

2011 - 2013 Research supervisor for Mehul Dhorda, Ph.D., Postdoctoral Fellow, Center for Vaccine Development Malaria Group/Mahidol University, Bangkok, Thailand

2011 - 2013 Research supervisor for Aamer Khattak, visiting fellow from Pakistan

2011 - 2012 Research supervisor for Rafael Sobota, NIH Fogarty International Clinical Research

2011 – present Research supervisor for Mary Sedegah, masters student in Molecular Medicine

2012 - 2015 Research supervisor for Amed Ouattara, Pharm.D. Ph.D., Postdoctoral Fellow, Center for Vaccine Development Malaria Group

2012 Research supervisor for Brittney Naylor, HHMI Exceptional Research Opportunities Program

2012 Research supervisor for Simon Emaikwu University of Maryland Baltimore County undergraduate student in Biochemistry & Molecular Biology (part-time)

2012 Research supervisor for Sarah Schaffer DeRoo, Benjamin H. Kean Traveling Fellowship in Tropical Medicine (Thailand)

2012 Research supervisor for Christian Larsen, Benjamin H. Kean Traveling Fellowship in Tropical Medicine (Myanmar)

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2012 Research supervisor for Scot Mu, medical student at Thomas Jefferson Medical College (summer)

2012 Research supervisor for Rungniran Sug-aram and Thirasak Hoonchaiyaphum, Ministry of Public Health, Thailand

2012 Research supervisor for Visiting Scientist Kay Thwe Han, Department of Medical Research Lower Myanmar

2012 - 2013 Research supervisor for Theo Abah, UMBC undergraduate student in Biochemistry & Molecular Biology (part-time)

2013 - 2017 Research supervisor for Fang Huang, Associate Professor, National Institute of Parasitic Diseases, China CDC

2013 - 2014 Research supervisor for Tyler Brown, Howard Hughes Medical Research Fellow

2013 Research supervisor for Martin Tinkerhess, HHMI Summer Medical Fellow

2013 Research supervisor for Bhavish Manwani, HHMI Summer Research Fellow

2013 Research supervisor for University of Maryland medical student Genna Jerrard, Benjamin H. Kean Traveling Fellowship in Tropical Medicine (Myanmar)

2013 Research supervisor for Sarah Brown, UMBC undergraduate student in Biochemistry & Molecular Biology (part-time)

2014 Research supervisor for University of Maryland medical student Ya Zhou Benjamin H. Kean Traveling Fellowship in Tropical Medicine (Myanmar)

2014 Research supervisor for Sara Nelson-Owens, Michael Skaro, and Bettie Wanjeri, Undergraduate Summer Research Fellows

2015 Research supervisor for Omar Hadied and Abigail Rosenberger, HHMI Summer Research Fellows

2015 Research supervisor for Eliza Calkins and Drew Dinsmore, Undergraduate Summer Research Fellows

2015 Research supervisor for Ann Marie Gustafson, Medical Student Summer Research Fellow

2015 - 2017 Research supervisor for Andrew Pike, Ph.D., Postdoctoral Fellow, Institute for Global Health, Division of Malaria Research

2015 - 2017 Research supervisor for Jason Bailey, Ph.D., Postdoctoral Fellow, Institute for Global Health, Division of Malaria Research

2015 - 2017 Research co-supervisor for Kayvan Zainabadi, Ph.D., Postdoctoral Fellow, Institute for Global Health, Division of Malaria Research

Johns Hopkins Bloomberg School of Public Health

1994 - 2007 Infectious Diseases and Child Survival, Department of International Health, annual Malaria Lecture. 20-30 graduate students, 2 hours/year.

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1997 - present Evolution and Spread of Drug Resistant Malaria, Department of Molecular Microbiology and Immunology, Malariology course lecture. 20-30 graduate students, 1.5 hours/year.

1997 - 2000, 2004 Malaria, Summer Institute on Tropical Medicine lecture - 2006 30-40 graduate students & health professionals, 1 hour/year.

1998 Supervisor for Preventive Medicine resident James Kublin, M.D.

1998 - 2000 Thesis advisor to Ph.D. candidate Fabian Mendez, Department of Epidemiology

1999 Supervisor for Preventive Medicine resident Elissa Malkin, M.D.

2001 Supervisor for Preventive Medicine resident Olugbenga Obasanjo, M.D.

University of Bamako Faculty of Medicine, Bamako, Mali

1994 Molecular field epidemiology: PCR detection of pyrimethamine resistant P. falciparum from finger stick blood on filter paper strips. Lecture, laboratory and field exercises in International Atomic Energy Agency sponsored course: Nuclear techniques for malaria research and control, Malaria Research and Training Center, Bamako, Mali. 20 international trainees, 10 contact hours.

1998 Molecular Epidemiology of Drug Resistant Malaria, 11th Annual Course in Epidemiology, Departments of Epidemiology of Parasitic Diseases and Public Health. 40 international trainees, contact time 2 hours.

1999 – present Co-supervisor for 4-8 training grant fellows for M.Sc. and Ph.D. degrees in Parasitology

2012 Molecular and Genomic Epidemiology of Malaria Learning and teaching parasite cell biology: A route to successful biomedical research in Africa, contact time 40 hours

University of Malawi College of Medicine, Blantyre, Malawi

1998 - 2000 Supervisor for research fellow Deborah Kamwenda, M.Sc.

1998 - 2003 Supervisor and co-thesis advisor for Ph.D. candidate Fraction Dzinjalamala (degree awarded by University of Cape Town)

2000 - 2002 Supervisor for research fellows Standwell Nkhoma and Rabia Mukadam

2002 - 2005 Co-thesis advisor for Standwell Nkhoma and Rabia Mukadam, Liverpool University

Other

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1997 Lecturer, Regional Training Course on Molecular Biology Techniques and Radionuclide Tracers in the Control of Malaria and Tuberculosis, Stellenbosch University, Cape Town, South Africa

1999 Lecturer, Regional Training Course on Isotopes and Molecular Techniques for Diagnosis and Control of Communicable Diseases, Stellenbosch University, Cape Town, South Africa

2004 Co-Organizer/Facilitator, Regional Training Course on Data Management and Quality Assurance Programme on Radionuclide Based Molecular Techniques in the Detection of Drug Resistant Malaria, University of Bamako, Mali

2005 - 2006 Lecturer, Scientific Writing, Fogarty International Center, for Fogarty International Center / Ellison Medical Foundation Overseas Fellows in Global Health and Clinical Research

2006 Facilitator, Atelier Paludisme (Course on Malaria), Institut Pasteur de Madagascar, Antananarivo, Madagascar

2011 Ph.D. thesis examiner, Rina Pok-Man Wong, University of Western Australia

2013 Lecturer, Genomic Epidemiology of Malaria Course Wellcome Trust Sanger Institute, Bangkok, Thailand

Areas of research interests (basic and applied) - list: Malaria research - epidemiology, clinical trials, molecular parasitology, immunology, population genetics, genomics, genomic epidemiology, geospatial modeling and mapping, HIV-malaria interactions and ethics of international research External support - gifts, grants, and contracts: Completed Grants:

Role Title Source Amount Dates (PI) Total Direct Costs: $97,134 11/95 - 11/97 “Drug resistant malaria in Mali” Interagency Personnel Act Agreement, Laboratory of Parasitic Diseases, NIAID/NIH (PI) Total Direct Costs: $40,000 4/96 - 4/98 “Studies of the safety and immunogenicity of live oral cholera vaccine strain CVD 103-HgR in HIV- infected and non-infected adults in Mali. WHO Global Programme on Vaccines grant (PI) Total Direct Costs: $41,681 11/96 - 10/98 “Transfection studies of drug resistance due to new mutations in P. falciparum DHFR and DHPS” WHO Committee on Malaria Pathogenesis – UNDP/World Bank/WHO Special Programme in Tropical

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Diseases Research. (Investigator) PI: O. Doumbo Total Direct Costs: $25,000 4/96 - 3/97 “The epidemiology of var gene expression in naturally acquired Plasmodium falciparum infections from an area of high endemicity” WHO Tropical Diseases Research grant (Investigator) PI: O. Doumbo Total Direct Costs: $2,750,003 4/96 - 3/01 “Malaria epidemiology and entomology in Mali” Tropical Medicine Research Center grant, NIH, NIAID (PI) Total Direct Costs: $11,375 7/96 - 6/97 “Basis of in vivo Plasmodium falciparum resistance to pyrimethamine-sulfadoxine” University of Maryland School of Medicine Intramural Grant (DRIF Award) (Investigator) PI: M. Levine Total Direct Costs: $536,031 4/97 - 3/00 “Multivalent Salmonella typhi-based malaria vaccines” NIH R01 - AI40297 (PI) Total Direct Costs: $349,997 9/97 - 9/99 “P. falciparum resistance to pyrimethamine-sulfadoxine” NIH R29-AI040539 (PI) Total Direct Costs: $140,269 9/97 - 9/98 “Expanded International Research on emerging & Re-emerging Diseases” NIH/NIAID (Investigator) PI: O. Doumbo 1/98 – 12/00 “Surveillance and control of drug-resistant malaria” Multilateral Initiative on Malaria – UNDP/World Bank/WHO Special Programme in Tropical Diseases Research Collaboration with University of Mali (Program Director) Total Direct Costs of supplement: $801,366 6/98 - 12/03 NIH / Fogarty International Center. New and minority scientist training program in Mali. Awarded as supplement to NIH Fellowship Training Program in Emerging Infectious Diseases (PI) Total Direct Costs: $9,022,744 9/98 – 10/05 “Malaria: Clinical research and trial preparation sites in endemic areas” NIH N01-AI85346 (PI) Total Direct Costs: $1,955,879 9/99 - 9/03 “Drug resistant malaria in Malawi” NIH R01-AI44824 Renewed as U01-AI044824 (Investigator) PI: M. Levine Total Direct Costs: $1,250,000 7/00 - 6/05 “Bacterial live vector-based vaccine against malaria” NIH R01-AI40297 (Faculty Mentor) PI: J. Kublin Total Direct Costs: $99,795 9/00 – 11/01 “Impact of TS prophylaxis on antifolate resistant malaria” NIH K01-TW000014 - International research scientist development award.

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(PI) Total Direct Costs: $937,542 9/00 – 5/05 “Trimethoprim-sulfamethoxazole prophylaxis and drug-resistant malaria in Malawi” NIH R01-AI47858 (Faculty Mentor) Co-PI: A. Djimde Total Direct Costs: $250,000 9/01 - 8/04 NIH Mentored Research Scholar Development Award. “Determinants of clearance of drug-resistant malaria” Awarded as supplement to NIH R01-AI44824 for administrative reasons. (Faculty Mentor) PI: K. Lyke Total Direct Costs: $424,730 2/02 - 1/06 “Immunologic interaction between schistosomiasis & acute malaria” NIH K23-AI049203 Mentored patient-oriented research career development award (Faculty Mentor) PI: M. Laufer Total Direct Costs: $682,848 7/04 - 6/09 “Molecular epidemiology of drug-resistant malaria” NIH K23-AI059316 Mentored patient-oriented research career development award (PI) Total Direct Costs: $1,977,451 6/04 - 9/10 “Clinical trial of chloroquine combinations in Malawi” NIH U01-AI044824 Competitive renewal of R01-AI44824 (PI) Total Direct Costs: $110,710 5/04 - 6/06 Supplement to “Malaria research training in Mali” NIH D43-TW-01589 For new Fogarty International Center / Ellison Medical Foundation Overseas Fellowships in Global Health and Clinical Research to train senior medical students in clinical tropical research in Mali (PI) Total Direct Costs: $1,154,772 6/05 - 5/09 “Trimethoprim-sulfamethoxazole prophylaxis and drug-resistant malaria in Malawi” NIH U01-AI47858 Competitive renewal of R01-AI47858 (PI) Total Direct Costs: $3,811,298 9/05 – 4/10 “Malaria vaccine trials in Mali” NIH U19-AI065683 International Collaborations in Infectious Diseases Research (ICIDR) (PI) Total Direct Costs: $557,557 3/06 – 10/09 “Pediatric clinical trials in Mali to determine potential benefit of AMA-1 as a component of a multi-antigen malaria vaccine” U.S. Army X81XWH-06-1-0427 USAMED Research ACQ Activity (PI) Total Direct Costs: $67,869 2/06 – 1/07 “Clinical trials in Mali” NIH PO1049 Malaria Vaccine Development Branch (PI) Total Direct Costs: $60,000 7/06 – 7/07 “Genetic diversity and efficacy of malaria drugs and vaccines” NAKFI Gen05. National Academies Keck Futures Initiative (PI) Total Direct Costs: $32,600 10/06 – 6/08 A longitudinal study of chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria in children in Blantyre Malawi

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Pfizer IIR GA-0660-IA (PI) Total Direct Costs: $75,000 09/07 – 08/08 “Molecular markers of Plasmodium falciparum resistance to artemisinins” 2008 UMB-UMCP NIH Seed Grant Competition Study (PI) Total Direct Costs: $1,500,000 1/07 – 12/11 “Genetic diversity and malaria vaccine efficacy” Doris Duke Distinguished Clinical Scientist Award (PI) Total Direct Costs: $400,000 2/08 – 10/09 “Artemisinin resistance – pilot studies confirm, characterize and plan for containment” WHO 48821 (Subcontract PI) Total Direct Costs: $369,373 5/08 – 4/12 “A global comparative study of the evolution of antimalarial drug resistance” NIH 1R01-GM084320 (Investigator) 6/08 – 01/16 “Genetic diversity and malaria drug and vaccine efficacy” Howard Hughes Medical Institute Investigator in Patient-Oriented Research (Faculty Mentor) PI: S. Takala Total Direct Costs: $430,000 7/08 – 6/13 “Genome-wide mapping of artemisinin resistance loci in Plasmodium falciparum malaria” K12 Clinical Research Career Development Program (PI) Total Direct Costs: $154,000 8/08 – 7/10 “Randomized, controlled trial of daily trimethoprim-sulfamethoxazole for weekly chloroquine among adults on antiretroviral therapy in Blantyre, Malawi” NIH R34-AI079284 (Co-Investigator) PI: M. Laufer Total Direct Costs: $176,150 8/08 – 7/10 “A randomized, controlled clinical trial of chloroquine as chemoprophylaxis versus intermittent preventive therapy to prevent malaria in pregnancy in Malawi” NIH R34-AI079315 (Subcontract PI) Total Direct Costs: $774,681 1/09 – 12/13 “Worldwide antimalarial drug resistance network” University of Oxford R10600/CN006 (WWARN) project (Subcontract PI) Total Direct Costs: $177,334 7/09 – 6/10 “Malaria research training for US medical student Fogarty Clinical Scholars in Mali” Vanderbilt University R24TW007988 Fogarty international clinical research scholars support center (PI) Total Direct Costs: $1,138,667 10/09 – 9/12 “Molecular surveillance of drug resistant malaria in the Greater Mekong Subregion” USAID, RDM/A RFP486-09-015 (PI) Total Direct Costs: $116,400 12/12 – 11/15 “Pilot studies of the molecular epidemiology of drug-resistant malaria in Myanmar” NIH R03AI101680 (PI) Total Direct Costs: $46,296 8/12 – 7/13 “Malaria research training in Mali”

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Supplement to this project, for Fogarty International Center / Malaria Research Training for Surveillance of Artemisinin Resistance in Myanmar NIH D43-TW-01589 (Subcontract PI) PI: Thura Total Direct Costs: $230,039 4/14 – 6/15 “Global Fund to Fight AIDS, Tuberculosis and Malaria, UNOPS Regional Artemisinin Initiative Inter-country Component 001-00090794 Community Partners International, Eliminating border based malaria” (PI) Total Direct Costs: $21,550 10/14 – 12/14 “Calculate prevalence estimates of K13 mutations within sites in Myanmar and Southern China.” WHO Technical Service Agreement (PI: 0.24 calendar months) Total Costs: $308,989 07/15 – 6/16 “Malaria indicator survey in Myanmar” Malaria Consortium - SCN6 MIS UMB (Subcontract PI) PI: S. Hoffman Total Costs: $99,899 6/13 – 5/16 “Chloroquine sensitive Plasmodium falciparum for multivalent vaccine & challenge” NIH/NIAID - R43AI108052 Sanaria Subaward (Co-investigator) PI: M. Laufer Total Costs: $5,266,931 6/10 – 5/16 “Clinical trial of chloroquine weekly or as IPT to prevent malaria in pregnancy in Malawi” NIH - U01AI087624 (PI) Total Costs: $7,712,762 9/05 – 6/16 “Genetic diversity and protective immunity to malaria infection and disease” NIH - U19AI065683/U01AI065683 (Subcontract PI) PI: Pyne Total Costs: $617,702 7/14 – 12/16 “Eliminating border-based malaria” Community Partners International - UNOPS_RAI_ICC_CPI_001_00090794 (PI) Total Costs: $35,934 10/16 – 12/16 “International Training on PCR Analysis for the Equatorial Guinea.” Sanaria Inc. (PI) Total Costs: $2,284,486 2/12 – 1/17 “Immuno-epidemiological epitope mapping of a blood stage malaria vaccine antigen” NIH - R01AI093635 (Co-investigator) PI: S. Harrison Total Costs: $1,818,352 3/13 – 2/17 “Genome-wide studies to identify markers of artemisinin-resistant malaria” NIH - R01AI101713 (Coordinating investigator) PI: M. Nyunt Total Costs: $4,626,240 10/14 – 03/17 “Evidence and action for malaria elimination in Myanmar” Bill and Melinda Gates Foundation - OPP1109551 (PI) Annual Direct Costs: $20,292 11/16 – 04/17 “To calculate prevalence estimates of K13 mutations within sites in Myanmar and Southern China” WHO 2016/670307-0

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(PI) Annual Direct Costs: $23,334 1/17 – 3/17 “International Training on PCR Analysis for the Equatorial Guinea” Sanaria Inc. Subcontract Marathon Oil, MCDI, Equatorial Guinea

(PI) Total Costs: $2,835,520 9/00 – 7/17 “Malaria research training in Mali” FIC/ NIH - D43TW001589 (Co-investigator) PI: M. Nyunt Annual Direct Costs: $228,668 1/17 – 12/17 “Defeat Malaria Burma” USAID, RFA-482-16-000001 – University Research Co. LLC subaward (PI) Annual Direct Costs: $170,879 1/17 – 12/17 “Eliminating Border-Based Malaria” Community Partners International - GF/2017/UMB/CPI-003 (Co-investigator: 1.2 calendar months) PI: M. Laufer

Total Costs: $7,949,031 8/11 – 7/18 “Clinical trial of trimethoprim-sulfamethoxazole or chloroquine in adults on ART” NIH - U01AI089342 (PI: 1.8 calendar months) Total Costs: $2,520,718 1/15 – 12/18 “Safety and efficacy of PfSPZ malaria vaccine in malaria-exposed adults” NIH - U01AI112367 (Co-investigator: 0.3 calendar months) PI: M. Nyunt Annual Direct Costs: $300,000 2/16 – 01/17 “Developing the Evidence for and assessing the Malaria Elimination Efforts among Mobile Migration Workers in Plantation Settings in Cambodia and Myanmar” Bill & Melinda Gates Foundation OPP1132753 Subaward from Population Services International (PI: 0.6 calendar months) Total Costs: $360,695 7/16 – 6/18 “Ultra-dense peptide array analysis of naturally acquired and vaccine-induced P. falciparum immunity” NIH/NIAID – R21AI119733-01A1 (MPI: C. Plowe/M. Laurens 0.6 calendar months) Total Costs: $2,791,483 9/16 – 11/18 “Safety, Tolerability, Immunogenicity and Protective Efficacy against Naturally-Transmitted Malaria of Infectious, Cryopreserved Plasmodium falciparum Sporozoites (PfSPZ Challenge) administered by Direct Venous Inoculation under Chloroquine Chemoprophylaxis (PfSPZ-CVac), A Randomized, Double Blind, Placebo-Controlled Trial” NIH - HHSN27200015-15-0052 Active Grants (Co-investigator: 0.6 calendar months) PI: Fraser

Annual Direct Costs: $2,064,652 4/14 – 3/19 “Host, pathogen, and the microbiome: determinants of infectious disease” NIH - U19AI110820 (PI: 0.6 calendar months) Total Costs: $1,785,679 9/15 – 5/19 “Variant surface antigens in cerebral malaria pathogenesis” NIH - R01HL130750

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(MPI: C. Plowe/M. Nyunt: 2.16 calendar months) Annual Direct Costs: $1,097,306 4/17 – 3/24 “Myanmar Regional Center of Excellence for Malaria Research” NIH/NIAID - U19AI129386 (Co-investigator: 0.24 calendar months) PI: T. Loboda Annual Direct Costs: $31,890 4/17 – 3/20 “Understanding the Role of Land Cover/Land Use Nexus in Malaria Transmission Under Changing Socio-Economic Climate in Myanmar” NASA LCLUC15_2-0025 Subaward from University of Maryland College Park (Mentor) PI: A. Berry Annual Direct Costs: $169,448 4/17 – 3/22 “Ultra-dense peptide array analysis of naturally acquired and vaccine-induced P. falciparum immunity” NIH (Co-investigator: 0.12 calendar months) PI: M. Nyunt Total Direct Costs $26,590 11/17 – 5/19 “Malaria Elimination Effort among Mobile Migrant Plantation Workers in Cambodia and Myanmar” Bill & Melinda Gates Foundation Subaward from Population Services International (Co-investigator: 0.3 calendar months) PI: M. Nyunt Total Direct Costs $356,193 11/17 – 5/19 “Defeat Malaria Initiative Myanmar” U.S. President’s Malaria Initiative Subaward from University Research Corporation (Coordinating Investigator: 0.84 calendar months) PI: M. Nyunt Total Direct Costs: $7,192,314 11/17 – 10/21 “Evidence to Action for Malaria Elimination in Myanmar” Bill & Melinda Gates Foundation OPP1171753 Participation in academic and administrative activities of the University and Medical Center: Director, Duke Global Health Institute 1/18-present Member, Medical Center Executive Committee 1/18-present