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Curriculum Vitae
Jean-Denis Docquier
Dati personali
Data e luogo di nascita 15 gennaio 1974 - Liegi, Belgio
Cittadinanza Belga
Stato civile Celibe
Domicilio 15, Via De Gasperi, I-53018, Volte Basse - Sovicille (SI)
Telefono 349 6148419
Formazione
2002 Dottorato di Ricerca in Scienze (Ph.D. Biochemical Sciences), Università di
Liegi, Belgio.
Titolo conseguito il 19 novembre 2002, dopo discussione pubblica di una tesi
intitolata "Metallo--lactamases, from clinical aspects to post-genomics: a
genetic and biochemical study".
Tesi eseguita sotto la direzione scientifica dei Prof. Jean-Marie Frère
(Università di Liegi, Belgio) e Prof. Gian Maria Rossolini (Università degli
Studi di Siena).
Dottorato finanziato dall’Unione Europea (programma “Training and
Mobility of Researchers”) nell’ambito del “European Network on the Study of
Metallo-β-lactamases: Integrated Approach to the Catalytic Mechanism and
Synthesis of Inhibitors of Metallo-β-lactamases” (contratto n° ERB-FMRX-
CT98-0232).
1998 Laurea (M. Sc.) in Scienze Biochimiche, Università di Liegi, Belgio.
1995 Diploma ("Candidat") in Scienze Chimiche, Università di Liegi, Belgio.
Curriculum Vitae – Jean-Denis Docquier
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Attività scientifica e competenze
Incarico attuale
Ricercatore confermato, Facoltà di Farmacia (fino a ottobre 2012) e Dipartimento di
Biotecnologie Mediche (da novembre 2012), Area Scientifica Microbiologica, Settore
scientifico disciplinare “Microbiologia e microbiologia clinica” (MED/07) (dal 1 marzo 2008).
Attività scientifica svolta presso il Laboratorio di Fisiologia e Biotecnologie dei Microrganismi
(Direttore, Prof. G. M. Rossolini), Dipartimento di Biotecnologie Mediche.
Linee di ricerca
Aspetti clinici della resistenza batterica agli antibiotici ed epidemiologia molecolare.
Caratterizzazione funzionale e strutturale delle β-lattamasi, in particolare la
caratterizzazione molecolare delle metallo-β-lattamasi, come effettori di resistenza agli
antibiotici β-lattamici in batteri patogeni, e come possibile bersaglio di inibitori
enzimatici.
Studio di metallo-β-lattamasi e di proteine strutturalmente correlate, individuate per via
post-genomica, come paradigma dell’evoluzione molecolare.
Indirizzo di lavoro
Laboratorio di Fisiologia e Biotecnologia dei Microrganismi,
Dipartimento di Biotecnologie Mediche,
Università degli Studi di Siena,
Policlinico “Le Scotte”, II piano, V lotto,
Viale Bracci,
I-53100 Siena
Telefono: +39 0577 233134 (int. 3134)
Fax: +39 9577 233870 (int. 3870)
E-mail: [email protected]
Altri laboratori frequentati
Centre d’Ingénierie des Protéines & Laboratoire d’Enzymologie (Pr. Jean-Marie Frère),
Università di Liegi, Liegi, Belgio.
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Institut di Biologie Structurale "Jean-Pierre Ebel" (Pr. Otto Dideberg), CNRS-CEA,
Grenoble, Francia.
Competenze
Tecniche di biologia molecolare, inclusa espressione eterologa.
Microbiologia di base, molecolare ed applicata.
Purificazione, analisi e caratterizzazione funzionale e strutturale delle proteine.
Lingue
Francese (lingua madre), inglese e italiano.
Attività di referaggio per riviste scientifiche
Membro dell’ “Editorial Board” (2009-2011) di Antimicrobial Agents and Chemotherapy
(ASM Press, Washington DC, USA)
Membro dell’ “Editorial Advisory Board” di Biochemical Pharmacology (Elsevier,
Oxford, UK)
Membro dell’ “Editorial Board” di The European Journal of Microbiology and
Immunology (Akademiai Kiado, Budapest, Hungary)
Membro dell’ “Editorial Board” di ISRN Microbiology (Hindawi Publishing
Corporation, New York, U.S.A.)
Journal of Antimicrobial Chemotherapy (Oxford University Press, UK)
Biochemistry (American Chemical Society, Washingtion DC, USA)
Microbiology (Society for General Microbiology, Reading, UK)
Clinical Microbiology and Infection (Blackwell Publishing, Oxford, UK)
Diagnostic Microbiology and Infectious Diseases (Elsevier, Amsterdam, The
Netherlands)
Journal of Infection (Elsevier, Amsterdam, The Netherlands)
Journal of Basic Microbiology (Wiley-VCH, Weinheim, Germany)
Journal of Medical Microbiology (Society for General Microbiology, Reading, UK)
Chemotherapy (Karger AG, Basel, Switzerland)
BMC Structural Biology (BioMed Central Ltd, London, UK)
PLOS ONE
Chemistry and Biology (Cell Press, Cambridge, USA)
Accounts of Chemical Research (American Chemical Society, Washingtion DC, USA)
Curriculum Vitae – Jean-Denis Docquier
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ACS Medicinal Chemistry Letters (American Chemical Society, Washingtion DC, USA)
Miscellaneo
Membro della “American Society for Microbiology” (ASM).
Membro della “Alliance for the Prudent Use of Antibiotics” (APUA).
Membro della “European Society of Clinical Microbiology and Infectious Diseases”
(ESCMID).
Membro del “ESCMID Study Group for Antimicrobial Resistance Surveillance”
(ESGARS).
Membro della Società Italiana di Microbiolgia (SIM).
Membro della Società Italiana di Microbiologia Medica, Odontoiatrica e Clinica
(SIMMOC)
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Attività didattica
Università degli Studi di Siena
2002 Professore a contratto della Facoltà di Farmacia, Insegnamento di
Microbiologia (Prof.ssa G. Coratza), modulo “Laboratorio di Microbiologia”
(MED/07), Laurea Specialistica in Chimica e Tecnologie Farmaceutiche (20
ore).
2002-2006 Collaboratore alla didattica, Microbiologia Applicata (Prof.ssa G. Coratza),
Corso Integrato di Biotecnologie Cellulari e Molecolari, Laurea Specialistica
in Biotecnologie per la Salute Umana, Facoltà di Farmacia (20 ore).
2003 Collaboratore alla didattica, Insegnamento di Microbiologia (Prof. G. M.
Rossolini), modulo “Microbiologia II”, Laurea Specialistica in Chimica e
Tecnologia Farmaceutiche, Facoltà di Farmacia (20 ore).
2004-2007 Professore a contratto della Facoltà di Farmacia, Insegnamento di
Microbiologia, modulo II “Laboratorio di Microbiologia” (MED/07), Laurea
Specialistica in Chimica e Tecnologia Farmaceutiche (24 ore).
dal 2006 Professore a Contratto della Facoltà di Medicina e Chirurgia, Insegnamento
“Proteine – DNA”, area propedeutica, Scuola di Specializzazione in
Microbiologia e Virologia (15 ore).
2007-2008 Professore a contratto della Facoltà di Farmacia, Insegnamento di
Microbiologia Applicata, Corso Integrato di Biotecnologie Cellulari e
Molecolari, Laurea Specialistica in Biotecnologie per la Salute Umana,
Facoltà di Farmacia (24 ore).
2008 Insegnamento di Microbiologia, modulo I “Microbiologia” e modulo II
“Laboratorio di Microbiologia” (MED/07), Laurea Specialistica in Chimica e
Tecnologia Farmaceutiche (44 ore).
2008 Insegnamento di Microbiologia Applicata, Corso Integrato di Biotecnologie
Cellulari e Molecolari, Laurea Specialistica in Biotecnologie per la Salute
Umana, Facoltà di Farmacia (24 ore).
2008 Insegnamento (corso a scelta studente) di Microbiologia Farmaceutica e
Applicata, Laurea Specialistica in Chimica e Tecnologia Farmaceutiche,
Facoltà di Farmacia (24 ore).
Curriculum Vitae – Jean-Denis Docquier
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2009-2011 Insegnamento di “Molecular Microbiology”, Modulo I “Molecular
microbiology for drug discovery (formulation and delivery)” e modulo II
“Vaccines Biotechnology”, Laurea Magistrale in “Pharmaceutical
Biotechonology” (in lingua inglese) (60 ore).
2010-2012 Insegnamento di “Analysis of Biotechnological Drugs”, Modulo II “Applied
and Pharmaceutical Microbiology”, Laurea Magistrale in “Pharmaceutical
Biotechonology” (in lingua inglese) (30 ore).
dal 2010 Insegnamento di “Analisi Microbiologiche”, Scuola di Specializzazione in
Farmacia Ospedaliera (8 ore).
dal 2010 Insegnamento di “Microbiologia ed Elementi di Epidemiologia”, Laurea
Magistrale in Farmacia (72 ore).
dal 2010 Insegnamento di Patologia Generale e Terminologia Medica e Microbiologia”
- Modulo II “Microbiologia”, Laurea Magistrale in Chimica e Tecnologia
Framnaceutiche (60 ore).
Altre università o istituzioni
1998 Collaboratore alla didattica, Laboratorio di Enzimologia (30 ore), Laurea in
Scienze Biochimiche, Facoltà di Scienze, Università di Liegi, Belgio.
2002 “Tutorial session, Detection of metallo--lactamases: kinetic aspects and
ancillary tests” (2 ore), 18th ESCMID Postgraduate Education Course
"Diagnostics, Characterization and Epidemiology of -lactamases", 22-23
aprile, 2002, Orta San Giulio, Italia.
2004 Collaboratore alla didattica, Laboratorio di Enzimologia (30 ore), Laurea in
Scienze Biochimiche, Facoltà di Scienze, Università di Liegi, Belgio.
2004 “Post-Graduate Course in Biochemistry, Topics in Biochemistry: Bacterial
Resistance to Antibiotics” (4 ore), Scuola di Dottorato in Scienze
Biochimiche, Università di Liegi, Belgio.
2004 Seminario di aggiornamento, “Problemi emergenti di antibiotico-resistenza
in ambiente ospedaliero e comunitario” (3 ore), Scuola di Specializzazione in
Microbiologia e Virologia, 28 maggio, 2004, Università degli Studi di Pavia.
2004 “Genomics, Proteomics and Resistance” (1 ora), Master in Microbiologia,
Università di Parigi V, VI and VII, Francia.
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2006 “36th ESCMID Post-Graduate Educational Course, “Detection and
Characterisation of Metallo-β-Lactamases”, 26-28 maggio 2006, Verona,
Italia
2008 “Post-Graduate Course in Biochemistry, Topics in Biochemistry: Bacterial
Resistance to Antibiotics” (12 ore), Scuola di Dottorato in Scienze
Biochimiche, Università di Liegi, Belgio.
Dal 2009 “Bacterial Resistance” (6.5 ore), Master in Biochimica e Biologia Moleculare
e Cellulare (corso opzionale), Università di Liegi, Belgio.
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Borse di studio, riconoscimenti e finanziamenti
Borsa di Dottorato dell’Unione Europea (Training and Mobility of Researchers
Program, 1998-2001) within the "European Network on the Study of Metallo--
Lactamases: Integrated approach to the catalytic mechanism and synthesis of inhibitors of
metallo--lactamases" (contract n° ERB-FMRX-CT98-0232).
“Collaborateur Scientifique et Chargé de Recherches”, Fonds National de la Recherche
Scientifique, Belgio (ottobre 2003 – settembre 2007).
Assegnista di Ricerca, Università di Siena (gennaio 2003 – dicembre 2006)
Student and Post Doctoral Travel Grant, American Society for Microbiology. 43rd
Interscience Conference on Antimicrobial Agents and Chemotherapy, September 14-17,
2003, Chicago, U.S.A. Comunicazioni premiate: (1) Biochemical characterization of
IMP-13, a new IMP variant produced by a Pseudomomas aeruginosa clinical isolate
from Italy, abstract n° C1-660. (2) Functional heterogeneity of VIM-type metallo--
lactamases: identification of residues critical to substrate binding, abstract n° C1-
662.
Coautore di un riassunto premiato dal “Programme Committee Award”, 44th
Interscience Conference on Antimicrobial Agents and Chemotherapy, 30 ottobre - 2
novembre, 2004, Washington, U.S.A. (Iannelli F., Santagati M., Docquier J.D.,
Cassone M., Oggioni M.R., Rossolini G.M., Stefani S., Pozzi G. Type M resistance
to macrolides in Streptococci is not due to the mefA gene, but to matA encoding an
ATP-dependent efflux pump, abstract n° C1-1188).
ESCMID Research Fellowship 2004, European Society of Clinical Microbiology and
Infectious Diseases (Award Committee President, Dr. Roger Finch).
ICAAC Young Investigator Award 2005, Interscience Conference on Antimicrobial
Agents and Chemotherapy, American Society for Microbiology.
ECCMID 2006 Travel Grant, European Society of Clinical Microbiology and Infectious
Diseases.
Premio “Agathon De Potter 2006” per la Microbiologia e la Biologia Vegetale, Académie
Royale des Sciences, Lettres et Beaux-Arts de Belgique.
Finanziamento “Grandi Attrezzature” – Fondazione Monte dei Paschi di Siena (importo
155.000 €), 2008.
Finanziamento “Regione Toscana” - Programma per la Ricerca Regionale in Materia di
Salute 2009 (importo 391.650 €), 2010 (Responsabile Unità di Ricerca).
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Attività istituzionale
Membro eletto del Consiglio del Dipartimento di Biologia Molecolare, Università di
Siena (rappresentante degli assegnisti di ricerca dal 2003 al 2006).
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Partecipazione a seminari, corsi di formazione e
congressi nazionali o internazionali
1. 2nd International Meeting on the Therapy of Infections, 18-21 novembre, 1998, Firenze,
Italia.
2. European Union Metallo--Lactamase Network Annual Meeting, 12-14 marzo, 1999,
Saarbrücken, Germania.
3. International EU/ESF Practical Training Course on "Chemistry of Metals in Biological
Systems", 15-25 maggio, 1999, Louvain-la-Neuve, Belgio.
4. International Congress on -Lactamases. "-lactamase Mediated Resistance: Molecular
Aspects and Clinical Implications", 17-20 giugno, 1999, L'Aquila, Italia.
5. 9th ESCMID Postgraduate Education Course: "The role of antibiotic resistance
surveillance for effective antibiotic policies", 9-11 dicembre, 1999, Verona, Italia.
6. European Union Metallo--Lactamase Network Annual Meeting, 7-9 aprile, 2000,
Copenhagen, Danimarca.
7. International Seminar: “Protein purification: What to do and how?”, 5-9 giugno, 2000,
Liège, Belgio.
8. European Union Metallo--Lactamase Network Mid-Term Review Meeting, 6-7 ottobre,
2000, Liegi, Belgio.
9. 3rd International Meeting on the Therapy of Infections, 4-6 dicembre, 2000, Firenze,
Italia.
10. European Union Metallo--Lactamase Network Annual Meeting, 30 novembre-2
dicembre, 2001, Siena, Italia.
11. 1st International Meeting on Penems, Carbapenems, and Related Compounds, NEMS'
2001, 13-15 dicembre, 2001, Venezia, Italia.
12. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy, ICAAC, 16-19
dicembre, 2001, Chicago, U. S. A.
13. 8th -Lactamase Workshop, 24-28 marzo, 2002, Holy Island, Northumberland, Regno
Unito.
14. 18th ESCMID Postgraduate Education Course "Diagnostics, Characterization and
Epidemiology of -lactamases", 22-23 aprile, 2002, Orta San Giulio, Italia.
15. 10° Congresso Nazionale SIMMOC, 19-21 giugno, 2002, Siena, Italia.
16. European Union Metallo--Lactamase Network Annual Meeting, 8-9 febbraio, 2003,
Copenhagen, Danimarca.
17. 13th European Congress of Clinical Microbiology and Infectious Diseases, ECCMID, 10-
13 maggio, 2003, Glasgow, Regno Unito.
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18. 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, 14-17
settembre, 2003, Chicago, U.S.A.
19. 31°Congresso Nazionale della Società Italiana di Microbiologia (SIM), 19-22 ottobre,
2003, Roma, Italia.
20. ESCMID-EU European Conference on “The Role of Research in Combating Antibiotic
Resistance”, 28-30 novembre, 2003, Roma, Italia.
21. European Union COBRA Network Kick-off Meeting, 16-17 aprile, 2004, Parigi, Francia.
22. 14th European Congress of Clinical Microbiology and Infectious Diseases, ECCMID, 1-4
maggio, 2004, Praga, Republica Ceca.
23. European Union Metallo--Lactamase Network Annual Meeting, 5-7 giugno, 2004,
Siena, Italia.
24. 12° Congresso Nazionale SIMMOC, 20-22 giugno, 2004, Genova, Italia.
25. 3rd Symposium on Protein Folding and Stability, 27 agosto 2004, Liège, Belgio.
26. European Union Metallo--Lactamase Network Mid-Term Review Meeting, 25-27
settembre, 2004, Liège, Belgio.
27. 44th Interscience Conference on Antimicrobial Agents and Chemotherapy, 30 ottobre– 2
novembre, 2004, Washington D.C., U.S.A.
28. European Union COBRA Network Annual Meeting, 26-27 novembre, 2004, Madrid,
Spagna.
29. European Union COBRA Network Annual Meeting, 3-4 giugno, 2005, Amsterdam,
Olanda.
30. 9th -Lactamase Workshop, 11-15 giugno, 2005, Leonessa, Italia.
31. ESCMID-APUA European Metallo-β-lactamase Expert Meeting, 14-15 novembre, 2005,
Siena, Italia.
32. 45th Interscience Conference on Antimicrobial Agents and Chemotherapy, 16-19
dicembre, 2005, Washington, U.S.A.
33. European Union COBRA Network Annual Meeting, 24-25 febbraio, 2006, Parigi,
Francia.
34. 16th European Congress of Clinical Microbiology and Infectious Diseases, ECCMID, 1-4
aprile, 2006, Nice, Francia.
35. 3° Congresso Nazionale della Società Italiana di Microbiologia Farmaceutica (SIMIF),
25-27 maggio, 2006, Cagliari, Italia.
36. 36th ESCMID Post-graduate Educational Course, “Detection and Characterisation of
Metallo-β-lactamases”, 26-28 maggio, 2006, Verona, Italia.
37. ESCMID Conference on Extended-Spectrum β-Lactamases, 29-31 maggio, 2006,
Venezia, Italia.
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38. 46th Interscience Conference on Antimicrobial Agents and Chemotherapy, 27-30
settembre, 2006, San Francisco, U.S.A.
39. European Union Metallo--Lactamase Network Annual Meeting, 1 dicembre, 2006,
Liegi, Belgio.
40. European Union COBRA Network Annual Meeting, 13-14 marzo, 2007, Lione, Francia.
41. 47th Interscience Conference on Antimicrobial Agents and Chemotherapy, 17-20
settembre, 2007, Chicago, U.S.A.
42. 18th European Congress of Clinical Microbiology and Infectious Diseases, 19-22 aprile,
2008, Barcellona, Spagna.
43. 10th β-lactamase meeting, 31 maggio – 4 giugno, 2008, Eretria, Grecia.
44. 36° Congresso Nazionale della Società Italiana di Microbiologia (SIM), 12-15 ottobre,
2008, Roma, Italia.
45. 7th International Symposium on Antimicrobial Agents and Resistance, 18-20 marzo,
2009, Bangkok, Thailandia.
46. Symposium in honour of Professor Jean-Marie Frère, “Penicillin-recognizing enzymes,
from enzyme kinetics to protein folding”, 1-3 luglio, 2009, Liegi, Belgio.
47. 49th Interscience Conference on Antimicrobial Agents and Chemotherapy, 12-15
settembre, 2009, San Francisco, U.S.A.
48. 50th Interscience Conference on Antimicrobial Agents and Chemotherapy, 12-15
settembre, 2010, Boston, U.S.A.
49. 21st European Congress of Clinical Microbiology and Infectious Diseases – 27th
International Conference on Chemotherapy, 7-10 maggio, 2011, Milano, Italy.
50. 1st European Conference of Microbiology and Immunology, 12-14 maggio, 2011,
Budapest, Hungary.
51. 11th β-lactamase meeting, 10-14 giugno, 2011, Leonessa, Italia.
52. 51st Interscience Conference on Antimicrobial Agents and Chemotherapy, 17-20
settembre, 2011, Chicago, U.S.A.
53. 40° congresso della Società Italiana di Microbiologia, 7-10 ottobre, Riccione, Italia.
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Comunicazioni scientifiche (atti di convegni)
1. Docquier J.D., Rossolini G.M., Frère J.M. Overproduction of two metallo--
lactamases, the Chryseobacterium meningosepticum BlaB and the Pseudomonas
aeruginosa VIM-1. International EU-ESF Practical Training Course. "Chemistry of
metals in biological systems", 15-25 maggio, 1999, Louvain-la-Neuve, Belgio.
Abstract book.
2. Docquier J.D., Riccio M.L., Frère J.M., Rossolini G.M. Overproduction of the
Pseudomonas aeruginosa VIM-1 metallo--lactamase in Escherichia coli. International
congress on -lactamases. "-lactamase mediated resistance: molecular aspects
and clinical implications", 17-20 giugno, 1999, L'Aquila, Italia. Abstract book,
abstract A9.
3. Vessilier S., Docquier J.D., Rival S., Frère J.M., Galleni M., Amicosante G.,
Rossolini G.M., Franceschini N. Overproduction and kinetic characterisation of
the Chryseobacterium meningosepticum BlaB metallo--lactamase. 46° Congresso
Nazionale della Società Italiana di Biochimica e Biologia Molecolare, 26-29
settembre, 2001, Siena, Italia. Pubblicato in Italian Biochemical Society Transactions
(2001) 17:72.
4. Pallecchi L., Castagnini C., Riccio M.L., Docquier J.D., Fontana R. Rossolini G.M.
Resistenza ai carbapenemi in Pseudomonas aeruginosa: ruolo delle metallo-β-
lattamasi acquisite. 29° Congresso Nazionale della Società Italiana di
Microbiologia, 7-10 novembre, 2001, Genova, Italia. Abstract book, p. 48.
5. Docquier J.D., Lamotte-Brasseur J., Amicosante G., Galleni M., Frère J.M.,
Rossolini G.M. Comparative kinetic characterization and modelling of the VIM-1
and VIM-2 metallo--lactamases. 1st International Meeting on Penems,
Carbapenems, and Related Compounds, 13-15 dicembre, 2001, Venezia, Italia.
Abstract book, abstract n° 33.
6. Docquier J.D., Luzzaro F., Lombardi G., Amicosante G., Toniolo A., Rossolini
G.M. Integron-borne VIM and IMP metallo--lactamases in Pseudomonas putida
clinical isolates from Northern Italy. 1st International Meeting on Penems,
Carbapenems, and Related Compounds, 13-15 dicembre, 2001, Venezia, Italia.
Abstract book, abstract n° 34.
7. Migliavacca R., Docquier J.D., Amicosante G., Rossolini G.M., Pagani L.
Discriminant test for routine detection of metallo--lactamase producers. 1st
International Meeting on Penems, Carbapenems, and Related Compounds, 13-15
dicembre, 2001, Venezia, Italia. Abstract book, abstract n° 35.
Curriculum Vitae – Jean-Denis Docquier
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8. Vessilier S., Docquier J.D., Rival S., Frère J.M., Galleni M., Amicosante G.,
Rossolini G.M., Franceschini N. Chryseobacterium meningosepticum BlaB
carbapenemase: interaction with -lactams and suicide inhibitors. 1st International
Meeting on Penems, Carbapenems, and Related Compounds, 13-15 dicembre,
2001, Venezia, Italia. Abstract book, abstract n° 39.
9. Mazzariol A., Docquier J.D., Xiaokang L., Cornaglia G. Activities of carbapenems
against porin-deficient strains of Escherichia coli producing a VIM-1 or IMP-1
-lactamase. 1st International Meeting on Penems, Carbapenems, and Related
Compounds, 13-15 dicembre, 2001, Venezia, Italia. Abstract book, abstract n° 41.
10. Docquier J.D., Lamotte-Brasseur J., Amicosante G., Galleni M., Frère J.M.,
Rossolini G.M. Overproduction and comparative kinetics of the VIM-1 and VIM-2
metallo--lactamases. 41st Interscience Conference on Antimicrobial Agents and
Chemotherapy, 16-19 dicembre, 2001, Chicago, U.S.A. Abstract book, abstract n°
1502.
11. Docquier J.D., Thaller M.C., Giulani F., Pantanella F., Garcia-Saez I., Frère J.M.,
Bush K., Rossolini G.M. Post-genomic identification and characterization of a
metallo--lactamase from Caulobacter crescentus. 41st Interscience Conference on
Antimicrobial Agents and Chemotherapy, 16-19 dicembre, 2001, Chicago, U.S.A.
Abstract book, abstract n° 1505.
12. Migliavacca R., Docquier J.D., Amicosante G., Rossolini G.M., Pagani L. New test
for phenotypic detection of metallo--lactamase producers. 41st Interscience
Conference on Antimicrobial Agents and Chemotherapy, 16-19 dicembre, 2001,
Chicago, U.S.A. Abstract book, abstract n° 181.
13. Docquier J.D., Rossolini G.M. Emergence and spread of metallo--lactamases.
Lecture. 18th ESCMID Postgraduate Education Course "Diagnostics,
Characterization and Epidemiology of -lactamases", 22-23 aprile, 2002, Orta San
Giulio, Italia.
14. Docquier J.D., Castagnini M., Lamotte-Brasseur J., Rossolini G.M. Eterogeneità
funzionale della metallo--lattamasi di tipo VIM: identificazione dei residui
importanti per la specificità di substrato. 10° Congresso Nazionale SIMMOC, 19-
21 giugno, 2002, Siena, Italia. Pubblicato in GIMMOC (2002) 6:122.
15. Luzzaro F., Docquier J.D., Mugnaioli C., Endimiani A., Amicosante G., Rossolini
G.M., Toniolo A. Prevalence of metallo--lactamases in clinical isolates of
Pseudomonas aeruginosa: a one-year survey. 42nd Interscience Conference on
Antimicrobial Agents and Chemotherapy, 27-30 settembre, 2002, San Diego,
U.S.A. Abstract book, abstract n° C2-1892.
Curriculum Vitae – Jean-Denis Docquier
pagina 15 di 31
16. Docquier J.D., Riccio M.L., Mugnaioli C., Luzzaro F., Toniolo A., Amicosante G.,
Rossolini G.M. IMP-12: a new plasmid-encoded IMP variant highly divergent
from IMP-1. 42nd Interscience Conference on Antimicrobial Agents and
Chemotherapy, 27-30 settembre, 2002, San Diego, U.S.A. Abstract book, abstract
n° C1-1847.
17. Docquier J.D., Mugnaioli C., Luzzaro F., Amicosante G., Toniolo A., Rossolini G.
M.. Diversity of IMP-type metallo--lactamases in carbapenem-resistant clinical
isolates of Pseudomonas spp. from Italy. 13th European Congress of Clinical
Microbioliogy and Infectious Diseases, 10-13 maggio, 2003, Glasgow, Regno
Unito. Abstract book, abstract P583. Pubblicato in Clinical Microbiology and
Infection (2003) 9 (Suppl. 1):121.
18. Luzzaro F., Docquier J.D., Colinon C., Endimiani A., Amicosante G., Rossolini
G.M., Toniolo A. First detection of Klebsiella pneumoniae and Enterobacter cloacae
clinical isolates producing the VIM-1 metallo--lactamase. 13th European
Congress of Clinical Microbioliogy and Infectious Diseases, 10-13 maggio, 2003,
Glasgow, Regno Unito. Abstract book, abstract P1052. Pubblicato in Clinical
Microbiology and Infection (2003) 9 (Suppl. 1):246.
19. Migliavacca R., Docquier J.D., Spalla M., Pallecchi L., Nucleo E., Giacobone E.,
Zara F., Brerra R., Rossolini G.M., Pagani L. Nosocomial infections caused by
Pseudomonas aeruginosa with acquired blaVIM metallo--lactamase genes in a
hospital from Northern Italy. 13th European Congress of Clinical Microbioliogy
and Infectious Diseases, 10-13 maggio, 2003, Glasgow, Regno Unito. Abstract
book, abstract P1211. Pubblicato in Clinical Microbiology and Infection (2003) 9
(Suppl. 1):287.
20. Docquier J.D., Mugnaioli C., Perilli M., Amicosante G., Rossolini G.M.
Biochemical characterization of IMP-13, a new IMP variant produced by a
Pseudomomas aeruginosa clinical isolate from Italy. 43rd Interscience Conference on
Antimicrobial Agents and Chemotherapy, 14-17 settembre, 2003, Chicago, U.S.A.
Abstract book, abstract n° C1-660.
21. Docquier J.D., Lamotte-Brasseur J., Amicosante G., Frère J.M., Rossolini G.M.
Functional heterogeneity of VIM-type metallo--lactamases: identification of
residues critical to substrate binding. 43rd Interscience Conference on
Antimicrobial Agents and Chemotherapy, 14-17 settembre, 2003, Chicago, U.S.A.
Abstract book, abstract n° C1-662.
22. Lopizzo T., D'Andrea M., Thaller M.C., Amicosante G., Rossolini G.M., Docquier
J.D. Purification and biochemical characterization of the THIN-B metallo--
lactamase from the environmental bacterium Janthinobacterium lividum. 43rd
Interscience Conference on Antimicrobial Agents and Chemotherapy, 14-17
settembre, 2003, Chicago, U.S.A. Abstract book, abstract n° C1-670.
Curriculum Vitae – Jean-Denis Docquier
pagina 16 di 31
23. Giuliani F., Docquier J.D., Riccio M.L., Pagani L., Rossolini G.M. Identification
and biochemical characterization of OXA-46, a new integron-encoded OXA-type
-lactamase from a Pseudomonas aeruginosa clinical isolate. 43rd Interscience
Conference on Antimicrobial Agents and Chemotherapy, 14-17 settembre, 2003,
Chicago, U.S.A. Abstract book, abstract n° C1-1183.
24. Riccio M.L., Pallecchi L., Docquier J.D., Cresti S., Fontana R., Pagani L., Monti-
Bragadin C., Rossolini G. M. Clonal relatedness of Pseudomonas aeruginosa
producing the VIM-1 metallo--lactamase from different Italian hospitals. 43rd
Interscience Conference on Antimicrobial Agents and Chemotherapy, 14-17
settembre, 2003, Chicago, U.S.A. Abstract book, abstract n° C1-2020.
25. Docquier J.D., Mugnaioli C., Amicosante G., Rossolini G.M. Diversity of IMP-
type metallo--lactamases in Italy: characterization of IMP-13, a new highly
divergent variant. 31° Congresso Nazionale della Società Italiana di
Microbiologia, 19-22 ottobre, 2003, Roma, Italia.
26. Luzzaro F., Docquier J.D., Endimiani A., Colinon C., Lombardi G., Amicosante
G., Rossolini G.M., Toniolo A. First detection of Klebsiella pneumoniae and
Enterobacter cloacae clinical isolates producing the VIM-1 metallo--lactamase. 31°
Congresso Nazionale della Società Italiana di Microbiologia, 19-22 ottobre, 2003,
Roma, Italia.
27. Docquier J.D., Stoczko M., Amicosante G., Frère J.M., Rossolini G.M. Post-
genomic identification of a new subclasss B3 metallo--lactamase (NOV-1) from
Novosphingobium aromaticivorans. 14th European Congress of Clinical
Microbioliogy and Infectious Diseases, 1-4 maggio, 2004, Praga, Republica Ceca.
Abstract book, abstract P1460. Pubblicato in Clinical Microbiology and Infection
(2004) 10 (Suppl. 3):410.
28. Docquier J.D., Mugnaioli C., Luzzaro F., Musmanno R.A., Rossolini G.M. New
aminoglycoside and chloramphenicol acetyltransferase-encoding gene cassettes
in class 1 integrons from multiresistant Pseudomonas aeruginosa clinical isolates.
14th European Congress of Clinical Microbioliogy and Infectious Diseases, 1-4
maggio, 2004, Praga, Republica Ceca. Abstract book, abstract P1461. Pubblicato in
Clinical Microbiology and Infection (2004) 10 (Suppl. 3):410.
29. Migliavacca R., Colinon C., Docquier J.D., Spalla M., Nucleo E., Li Bergoli M.,
Labonia M., Rossolini G.M., Pagani L. Outbreak of multiresistant Pseudomonas
aeruginosa producing the metallo--lactamase IMP-13 in a general intensive care
unit in southern Italy. 14th European Congress of Clinical Microbioliogy and
Infectious Diseases, 1-4 maggio, 2004, Praga, Republica Ceca. Abstract book,
abstract P1876. Pubblicato in Clinical Microbiology and Infection (2004) 10 (Suppl.
3):537.
Curriculum Vitae – Jean-Denis Docquier
pagina 17 di 31
30. Labonia M., Li Bergoli M., Migliavacca R., Colinon C., Docquier J.D., Spalla M.,
Nucleo E., Rossolini G.M., Pagani L. Epidemia di Pseudomonas aeruginosa
multiresistenti, produttori di metallo--lattamasi IMP-13, in una unità di terapia
intensiva dell’IRCSS “Casa Sollievo della Sofferenza” di San Giovanni Rotondo
(FG). 33° Congresso Nazionale dell’Associazione dei Microbiologi Clinici Italiani
(AMCLI), 8-11 giugno, 2004, Padova, Italia. Pubblicato in Microbiologia Medica
(2004) 19:193.
31. Docquier J.D., Borgianni L., Frère J.M., Rossolini G.M. Analisi della relazione
struttura-funzione della metallo--lattamasi VIM-2 tramite mutagenesi a
saturazione: ruolo della tasca idrofobica del sito catalitico nell’attività enzimatica.
12° Congresso Nazionale SIMMOC, 20-22 giugno, 2004, Genova, Italia.
32. Iannelli F., Santagati M., Docquier J.D., Cassone M., Oggioni M.R., Rossolini
G.M., Stefani S., Pozzi G. La resistenza di tipo M ai macrolidi negli Streptococchi
non è dovuto al gene mefA ma al gene matA che codifica una pompa ad efflusso
ATP-dipendente. 12° Congresso Nazionale SIMMOC, 20-22 giugno, 2004,
Genova, Italia.
33. Iannelli F., Santagati M., Docquier J.D., Cassone M., Oggioni M.R., Rossolini
G.M., Stefani S., Pozzi G. La resistenza di tipo M ai macrolidi negli streptococchi è
dovuta ad un sistema di efflusso della superfamiglia dei trasportatori ABC (ATP-
binding cassette). 32° Congresso Nazionale Società Italiana di Microbiologia
(SIM), Milano, 26-29 settembre 2004.
34. Docquier J.D., Longatti A., Amicosante G., Frère J.M., Rossolini G.M. Post-
genomic identification and characterization of a new subclass B2 metallo--
lactamase encoded by the chromosome of Chromobacterium violaceum. 44th
Interscience Conference on Antimicrobial Agents and Chemotherapy, 30 ottobre-
2 novembre, 2004, Washington, U.S.A. Abstract book, abstract n° C1-289.
35. Docquier J.D., Borgianni L., Frère J.M., Rossolini G.M. Structure-function
relationship analysis of the VIM-2 metallo--lactamase by saturation mutagenesis:
role of the active site hydrophobic pocket in enzyme activity. 44th Interscience
Conference on Antimicrobial Agents and Chemotherapy, 30 ottobre- 2 novembre,
2004, Washington, U.S.A. Abstract book, abstract n° C1-963.
36. Iannelli F., Santagati M., Docquier J.D., Cassone M., Oggioni M.R., Rossolini
G.M., Stefani S., Pozzi G. Type M resistance to macrolides in Streptococci is not
due to the mefA gene, but to matA encoding an ATP-dependent efflux pump. 44th
Interscience Conference on Antimicrobial Agents and Chemotherapy, 30 ottobre-
2 novembre, 2004, Washington, U.S.A. Abstract book, abstract n° C1-1188.
37. Stoczko M, Frère J.M., Rossolini G.M., Docquier J.D. JAP-1, a new member of
subclass B3 metallo-β-lactamase from Bradyrhizobium japonicum. 15th European
Congress of Clinical Microbiology and Infectious Diseases, 2-5 aprile, 2005,
Copenhagen, Danimarca. Abstract book, abstract P411. Pubblicato in Clinical
Microbiology and Infection (2005) 11 (Suppl. 2):100.
Curriculum Vitae – Jean-Denis Docquier
pagina 18 di 31
38. De Santis F., Caporale B., Celenza G., Fiore M., Pellegrini C., Perilli M., Docquier
J.D., Rossolini G.M., Amicosante G. Distribution of β-lactamases in clinical
isolates of Enterobacteriaceae and nonfermenters from a region of central Italy. 15th
European Congress of Clinical Microbiology and Infectious Diseases, 2-5 aprile,
2005, Copenhagen, Danimarca. Abstract book, abstract P790. Pubblicato in Clinical
Microbiology and Infection (2005) 11 (Suppl. 2):234.
39. Rossolini G.M., Docquier J.D. Metallo-β-lactamases: a last frontier for β-lactams.
15th European Congress of Clinical Microbiology and Infectious Diseases, 2-5
aprile, 2005, Copenhagen, Danimarca. Abstract book, abstract K371. Pubblicato in
Clinical Microbiology and Infection (2005) 11 (Suppl. 2):88-89.
40. Iannelli F., Santagati M., Docquier J.D., Cassone M., Oggioni M.R., Rossolini
G.M., Stefani S., Pozzi G. Type M resistance to macrolides is due to an efflux
transport system of the ATP-binding cassette (ABC) superfamily.
EUROPNEUMO, 8-11 maggio 2005, Braunschweig, Germania. Abstract book,
abstract n° O4.2.
41. Voha C., Docquier J.D., Rossolini G.M., Fosse T. Biochemical characterization of
FUS-1, a narrow-spectrum class D β-lactamase from a Fusobacterium nucleatum
polymorphum clinical isolate. 45th Interscience Conference on Antimicrobial Agents
and Chemotherapy, 16-19 dicembre, 2005, Washington, U.S.A. Abstract book,
abstract n° C1-73.
42. Calderone V., Giuliani F., Benvenuti M., Docquier J.D., Nordmann P., Mangani
S., Rossolini G.M. Structural and functional characterization of OXA-48 β-
lactamase: first structure of a class D carbapenemase. 45th Interscience Conference
on Antimicrobial Agents and Chemotherapy, 16-19 dicembre, 2005, Washington,
U.S.A. Abstract book, abstract n° C1-81.
43. Zéba B., Simporé J., Nacoulma O.G., Rossolini G.M., Frère J.M., Docquier J.D.
Characterization of a new IND variant from Chryseobacterium indologenes: first
report of a metallo-β-lactamase-producing clinical isolate from Africa. 45th
Interscience Conference on Antimicrobial Agents and Chemotherapy, 16-19
dicembre, 2005, Washington, U.S.A. Abstract book, abstract n° C1-85.
44. Docquier J.D., Bundone L., Frère J.M., Streit W.R., Rossolini G.M. Biochenical
characterization of ILM-1, a new IMP-like metallo-β-lactamase from a soil
metagenome. 45th Interscience Conference on Antimicrobial Agents and
Chemotherapy, 16-19 dicembre, 2005, Washington, U.S.A. Abstract book, abstract
n° C1-86.
45. Stoczko M., Frère J.M., Rossolini G.M., Docquier J.D. Metallo-β-lactamase
homologues in the Rhizobacteria: Identification of new subclass B3 metallo-β-
lactamases. 45th Interscience Conference on Antimicrobial Agents and
Chemotherapy, 16-19 dicembre, 2005, Washington, U.S.A. Abstract book, abstract
n° C1-87.
Curriculum Vitae – Jean-Denis Docquier
pagina 19 di 31
46. Docquier J.D., Prandi S., Cresti S., Rossolini G.M. Biochemical characterization of
the plasmid-encoded class C β-lactamase FOX-7. 16th European Congress of
Clinical Microbioliogy and Infectious Diseases, 1-4 aprile, 2006, Nizza, Francia.
Abstract book, abstract P512. Pubblicato in Clinical Microbiology and Infection
(2006) 12 (Suppl. 4):137.
47. Stoczko M., Frère J.M., Rossolini G.M., Docquier J.D. Post-genomic detection of
CAR-1, a new subclass B3 metallo-β-lactamase from the important plant pathogen
Erwinia carotovora. 16th European Congress of Clinical Microbiology and Infectious
Diseases, 1-4 aprile, 2006, Nizza, Francia. Abstract book, abstract P926. Pubblicato
in Clinical Microbiology and Infection (2006) 12 (Suppl. 4):285-286.
48. Docquier J.D., D’Andrea M.M., Christiaens G., Boreux R., Giani T., Frère J.M., De
Mol P., Rossolini G.M. Genetic structure of a VIM-2-encoding integron from a
Pseudomonas aeruginosa clinical isolate from Belgium. 16th European Congress of
Clinical Microbiology and Infectious Diseases, 1-4 aprile, 2006, Nizza, Francia.
Abstract book, abstract P930. Pubblicato in Clinical Microbiology and Infection
(2006) 12 (Suppl. 4):287.
49. Perilli M., Segatore B., Caporale B., Pellegrini C., Celenza G., De Santis F., Fiore
M., Luzi C., Docquier J.D., Rossolini G.M., Amicosante G. Biochemical
characterisation of IND-NF16 metallo-β-lactamase. 16th European Congress of
Clinical Microbiology and Infectious Diseases, 1-4 aprile, 2006, Nizza, Francia.
Abstract book, abstract P934. Pubblicato in Clinical Microbiology and Infection
(2006) 12 (Suppl. 4):288-289.
50. Borgianni L., Frère J.M., Coratza G., Rossolini G.M., Docquier J.D. Analisi della
relazione struttura-funzione della metallo-β-lattamasi VIM-2 tramite mutagenesi
a saturazione: ruolo della tasca idrofobica del sito catalitico nell’attività
enzimatica. III° Congresso Nazionale della Società Italiana di Microbiologia
Farmaceutica (SIMIF), 25-27 maggio, 2006, Cagliari, Italy. Abstract book.
51. Docquier J.D., Prandi S., Cresti S., Rossolini G.M. Caratterizzazione biochimica
della β-lattamasi di classe C di origine plasmidica FOX-7. III° Congresso
Nazionale della Società Italiana di Microbiologia Farmaceutica (SIMIF), 25-27
maggio, 2006, Cagliari, Italy. Abstract book.
52. Oggioni M.R., Pettini E., Camilli R., Paterson G. K., Del Grosso M., Docquier J.D.,
Athwal J., Mitchell T.J., Kilian M., Pantosti A., Pozzi G. Pneumococcal zinc
metalloproteinases: epidemiology, virulence, and processing. ASM Conference on
Streptococcal Genetics. 18-21 giugno 2006, Saint-Malo, France.
53. Calderone V., Giuliani F., Benvenuti M., Docquier J.D., Nordmann P., Rossolini
G.M., Mangani S. Structural and functional characterization of two new β-
lactamases: OXA-46 and OXA-48. 23rd European Crystallographic Meeting, 6-11
agosto, 2006, Leuven, Belgium. Abstract book, abstract m11.p02. Pubblicato in
Acta Cryst. (2006) A62:s161.
Curriculum Vitae – Jean-Denis Docquier
pagina 20 di 31
54. Calderone V., Giuliani F., Benvenuti M., Docquier J.D., Rossolini G.M., Mangani
S. The uneasy task to correlate structure to function: the case of class D β-
lactamases. XXXV Annual Meeting of the Italian Association of Crystallography,
18-21 settembre, 2006, Ferrara, Italy. Abstract book.
55. Voha C., Calderone V., Benvenuti M., Mangani S., Rossolini G.M., Fosse T.,
Docquier J.D. Crystal structure and mutational analysis of FUS-1 (OXA-85), a
class D β-lactamase from Fusobacterium nucleatum subsp. polymorphum. 46th
Interscience Conference on Antimicrobial Agents and Chemotherapy, 27-30
settembre, 2006, San Francisco, U.S.A. Abstract book, abstract n° C1-26.
56. Borgianni L., Frère J.M., Rossolini G.M., Docquier J.D. Mutational analysis of the
VIM-2 active site: role of positions 64 and 87 in enzyme activity and stability. 46th
Interscience Conference on Antimicrobial Agents and Chemotherapy, 27-30
settembre, 2006, San Francisco, U.S.A. Abstract book, abstract n° C1-28.
57. Docquier J.D., De Luca F., Lee K., Chong Y., Rossolini G.M. Biochemical
characterization of SIM-1, a new integron-borne subclass B1 metallo-β-lactamase
from Acinetobacter baumannii isolates from Korea. 46th Interscience Conference on
Antimicrobial Agents and Chemotherapy, 27-30 settembre, 2006, San Francisco,
U.S.A. Abstract book, abstract n° C1-56.
58. Christiaens G., Damas P., Docquier J.D., Hayette M., Melin P., De Mol P.
Molecular epidemiology of extended-spectrum β-lactamases-producing
Enterobacteriaceae colonizing the digestive tract of patients admitted to intensive
care units in a Belgian university hospital. 46th Interscience Conference on
Antimicrobial Agents and Chemotherapy, 27-30 settembre, 2006, San Francisco,
U.S.A. Abstract book, abstract n° C2-105.
59. Helfand M.S., Taracila M.A., Borgianni L., Docquier J.D., Venkatesan A.M.,
Mansour T.S. Inhibition of Class A, B and C β-lactamases (βLs) by Bicyclic 6-
Methylidene Penems via Michaelis Complexes and Cyclic Enamines. 47th
Interscience Conference on Antimicrobial Agents and Chemotherapy, 17-20
settembre, 2007, Chicago, U.S.A. Abstract book, abstract n° C1-94.
60. Giraud-Morin C., De Luca F., Rossolini G.M., Docquier J.D., Fosse T. Genetic and
Biochemical Characterization of TRU-1, the Endogenous Class C β-lactamase
from Aeromonas trota. 47th Interscience Conference on Antimicrobial Agents and
Chemotherapy, 17-20 settembre, 2007, Chicago, U.S.A. Abstract book, abstract n°
C1-592.
61. Mereuta A.I., Buiuc, D.T., Rossolini G.M, Docquier J.D. Simultaneous Detection
of VIM-2 and IMP-13-Producing Carbapenem-Resistant Pseudomonas aeruginosa
Clinical Isolates from Romania. 47th Interscience Conference on Antimicrobial
Agents and Chemotherapy, 17-20 settembre, 2007, Chicago, U.S.A. Abstract book,
abstract n° C2-1498.
Curriculum Vitae – Jean-Denis Docquier
pagina 21 di 31
62. Docquier J.D., Xerri L. Interaction of PZ-601 (SMP-601) and other β-lactams with
chromosome- and plasmid-encoded class C β-lactamases. 18th European Congress
of Clinical Microbiology and Infectious Diseases, 19-22 aprile, 2008, Barcelona,
Spagna. Abstract book, P566.
63. Docquier J.D., Xerri L. Stability of PZ-601 (SMP-601) to different clinically-
relevant extended-spectrum β-lactamases. 18th European Congress of Clinical
Microbiology and Infectious Diseases, 19-22 aprile, 2008, Barcelona, Spagna.
Abstract book, P565.
64. Borgianni L., Matagne A., Frère J.M., Rossolini G.M., Docquier J.D. Structure-
function relationship analysis of the VIM-2 metallo-β-lactamase: identification of
a residue critical to enzyme structure. 10th β-lactamase meeting, 31 maggio – 4
giugno, 2008, Eretria, Grecia.
65. De Luca F., Rossolini G.M., Fosse T., Docquier J.D. Biochemical characterization
of TRU-1, the endogenous class C β-lactamase from Aeromonas trota. 10th β-
lactamase meeting, 31 maggio – 4 giugno, 2008, Eretria, Grecia.
66. Oggioni M.R., Athwal J., Trappetti C., Pozzi G., Docquier J.D., Andrew P.W.
Enzyme kinetics and substrate specificity of neuraminidases A, B and C of
Streptococcus pneumoniae. 6th International Symposium on Pneumococci &
Pneumococcal Diseases, 8-12 giugno 2008, Reykjavik, Islanda.
67. Docquier J.D., De Luca F., Giuliani F., Calderone V., Benvenuti M., Nordmann P.,
Mangani S., Rossolini G.M. Structural and functional analysis of the OXA-48 class
D carbapenemase: implications for the catalytic mechanism. 36° Congresso
Nazionale della SIM, 12-15 ottobre, 2008, Roma, Italia.
68. Voha C., Docquier J. D., Bonnaure-Mallet M., Kononen E., Fosse T. Antibiotic
susceptibility and distribution of β-lactamases in Fusobacterium species. 48th
Interscience Conference on Antimicrobial Agents and Chemotherapy / ISDA 46th
Annual Meeting, 25-28 ottobre, 2008, Washington DC, U.S.A. Abstract book,
abstract n° C2-3910.
69. Borgianni L., De Luca F., Rossolini G.M., Docquier J.D. ME-1071, a novel metallo-
β-lactamase inhibitor: inhibition mechanism and in vitro synergistic activity
against MBL-producing gram-negative pathogens. 48th Interscience Conference
on Antimicrobial Agents and Chemotherapy / ISDA 46th Annual Meeting, 25-28
ottobre, 2008, Washington DC, U.S.A. Abstract book, abstract n° F1-1170.
70. Borgianni L., Prandi S., Salden L., Hanson N.D., Rossolini G.M., Docquier J.D.
Genetic and biochemical characterization of IMP-18, a MBL determinant
identified in a Pseudomonas aeruginosa isolate from the U.S.A. 7th International
Symposium on Antimicrobial Agents and Resistance, 18-20 marzo, 2009,
Bangkok, Thailandia. Abstract book, abstract n° GN 099.
Curriculum Vitae – Jean-Denis Docquier
pagina 22 di 31
71. Poirel L., Docquier J.D., De Luca F., Verlinde A., Ide L., Rossolini G.M.,
Nordmann P. BEL-2, an expanded-spectrum β-lactamase with increased activity
toward broad-spectrum cephalosporins in Pseudomonas aeruginosa. 19th European
Congress of Clinical Microbiology and Infectious Diseases, 16-19 maggio, 2009,
Helsinki, Finlandia. Abstract book, abstract P1485.
72. Docquier J.D. Structure and function of class D carbapenemases. Symposium in
honour of Professor Jean-Marie Frère, “Penicillin-recognizing enzymes, from
enzyme kinetics to protein folding”, 1-3 luglio, 2009, Liège, Belgio.
73. Borgianni L., Prandi S., Salden L., Santella G., Hanson N.D., Rossolini G.M.,
Docquier J.D. Genetic and biochemical characterization of IMP-18, a MBL
determinant identified in a Pseudomonas aeruginosa isolate from the U.S.A. 49th
Interscience Conference on Antimicrobial Agents and Chemotherapy, 12-15
settembre, 2009, San Francisco, U.S.A. Abstract book, abstract n° C1-090.
74. Docquier J.D., Stachyra T., Benvenuti M., Rossolini G.M., Mangani S., Pechereau
M.C., Bruneau J.M., Claudon M., Barbosa F., Miossec C., Black M.T. High
resolution crystal structure of CTX-M-15 in complex with the new β-lactamase
inhibitor NXL104. 49th Interscience Conference on Antimicrobial Agents and
Chemotherapy, 12-15 settembre, 2009, San Francisco, U.S.A. Abstract book,
abstract n° C1-1098.
75. Borgianni L., Vandenameele J., Matagne A., Bonomo R.A., Frère J.M., Rossolini
G.M., Docquier J.D. Tryptophan 87 of the VIM-2 metallo-β-lactamase is essential
for stability, in vivo folding and β-lactam resistance. 49th Interscience Conference
on Antimicrobial Agents and Chemotherapy, 12-15 settembre, 2009, San
Francisco, U.S.A. Abstract book, abstract n° C1-1369.
76. Morinaka A., Ohkuma K., Matsumoto K., Mikuniya T., Sakakibara S., Maebashi
K., Suzuki H., Docquier J.D., Rossolini G.M. In vivo efficacy of ME1071, a novel
metallo-β-lactamase (MBL) inhibitor, in combination with carbapenems against
MBL-producing Pseudomonas aeruginosa in a murine pneumonia model. 49th
Interscience Conference on Antimicrobial Agents and Chemotherapy, 12-15
settembre, 2009, San Francisco, U.S.A. Abstract book, abstract n° F1-1491.
77. De Luca F., Benvenuti M., Carboni F., Rossolini G.M., Docquier J.D., Mangani S.
Evolution of a β-lactamase by rational protein design and loop grafting: changing
an oxacillinase in a carbapenemase. 2nd Meeting of the Italian and Spanish
Crystallographic Associations, 30 giugno – 3 luglio, 2010, Oviedo, Spain.
78. Docquier J.D., Benvenuti M., De Luca F., Rossolini G.M., Mangani S., Miossec C.,
Black T.M. X-ray crystal structure of the Klebsiella pneumoniae OXA-48 class D
carbapenemase inhibited by NXL104. 50th Interscience Conference on
Antimicrobial Agents and Chemotherapy, 12-15 settembre, 2010, Boston, U.S.A.
Abstract book, abstract n° C1-640.
Curriculum Vitae – Jean-Denis Docquier
pagina 23 di 31
79. De Luca F., Benvenuti M., Carboni F., Rossolini G.M., Mangani S., Docquier J.D.
Evolution of a β-lactamase by rational protein design and loop grafting: changing
an oxacillinase in a carbapenemase. 50th Interscience Conference on
Antimicrobial Agents and Chemotherapy, 12-15 settembre, 2010, Boston, U.S.A.
Abstract book, abstract C1-646.
80. Docquier J.D., Benvenuti M., De Luca F., Rossolini G.M., Mangani S., Miossec C.,
Black T.M. Structure of the TRU-1 class C and OXA-10 class D β-lactamases in
complex with NXL104: structural basis for broad-spectrum inhibition. 50th
Interscience Conference on Antimicrobial Agents and Chemotherapy, 12-15
settembre, 2010, Boston, U.S.A. Abstract book, abstract n° C1-1427.
81. Santela G., Pollini S., Docquier J.D., Mereuta A.I., Gutkind G., Rossolini G.M.,
Radice M. Global spread of IMP-13-producing Pseudomonas aeruginosa sequence
type 621. 50th Interscience Conference on Antimicrobial Agents and
Chemotherapy, 12-15 settembre, 2010, Boston, U.S.A. Abstract book, abstract n°
C2-1804.
82. Docquier J.D., Benvenuti M., De Luca F., Rossolini G.M., Mangani S., Miossec C.,
Black T.M. Structure of the TRU-1 class C and OXA-10 class D β-lactamases in
complex with NXL104: structural basis for broad-spectrum inhibition. Advances
in Protein Crystallography, 9-10 novembre, 2010, Firenze, Italia.
83. Docquier J.D., Benvenuti M., Bruneau J.M., Rossolini G.M., Mangani S., Miossec
C., Black M.T. X-ray Crystal Structure of the Acinetobacter baumannii OXA-24/40
Class D Carbapenemase Inhibited by NXL104. 21st European Congress of Clinical
Microbiology and Infectious Diseases/27th International Congress of
Chemotherapy and Infection (Joint ECCMID-ICC meeting), 7-10 maggio 2011,
Milano, Italia.
84. Docquier J.D. Clinically-relevant β-lactamases: Structure-function relationships
and inhibition. 1st European Conference of Microbiology and Immunology, 12-14
maggio, 2011, Budapest, Hungary.
85. Borgianni L., Giacobini G., Rossolini G.M., Docquier J.D. Structure-fucntion
relationship of the NDM-1 metallo-beta-lactamase: Importance of Trp-87 in
enzyme structure, function and stability. 51st Interscience Conference on
Antimicrobial Agents and Chemotherapy, 17-20 settembre, 2011, Chicago, U.S.A.
Abstract book, abstract n° C1-531.
86. Cejas D., De Luca F., Gutkind G., Rossolini G.M., Radice M., Docquier J.D.
Probing the role of R2-loop deletions and substituions on the functional
properties of the acquired AmpC-type β-lactamase CMY-2. 51st Interscience
Conference on Antimicrobial Agents and Chemotherapy, 17-20 settembre, 2011,
Chicago, U.S.A. Abstract book, abstract n° C1-607.
87. Docquier J.D. Structure and function of metallo-β-lactamases. Meet-the-Experts
session “Structure, Function and Genetics of Metallo-β-Lactamases”. 51st
Curriculum Vitae – Jean-Denis Docquier
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Interscience Conference on Antimicrobial Agents and Chemotherapy, 17-20
settembre, 2011, Chicago, U.S.A. Abstract book, abstract n° 1038.
88. Di Lorenzo V., Decorosi F., Gualdi L., Docquier J.D., Giovannetti L., Viti C.,
Oggioni M.R. Phenotypic profiling of Pseudomonas aeruginosa planktonic growth,
biofilm formation and fluorescence. SIMGBM 29th National Meeting, 21-23
settembre, 2011, Pisa, Italia.
89. Docquier J.D. Antibiotico-resistenza e Batteri ambientali. 40° congresso della
Società Italiana di Microbiologia, 7-10 ottobre, 2012, Riccione, Italia.
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Pubblicazioni in extenso
1. Pierrard A., Ledent P., Docquier J.D., Feller G., Gerday C., Frère J.M. Inducible
class C -lactamases produced by psychrophilic bacteria. FEMS Microbiol. Lett.
(1998) 161:311-315.
2. Franceschini N., Caravelli B., Docquier J.D., Galleni M., Frère J.M., Amicosante
G., Rossolini G.M. Purification and biochemical characterization of the VIM-1
metallo--lactamase. Antimicrob. Agents Chemother. (2000) 44:3003-7.
3. Pallecchi L., Riccio M.L., Docquier J.D., Fontana R., Rossolini G.M. Molecular
heterogeneity of blaVIM-2-containing integrons from Pseudomonas aeruginosa
plasmids encoding the VIM-2 metallo--lactamase. FEMS Microbiol. Lett. (2001)
195:145-50.
4. Rossolini G.M., Condemi M.A., Pantanella F., Docquier J.D., Amicosante G.,
Thaller M.C. Metallo--lactamase producers in environmental microbiota: new
molecular class B enzyme in Janthinobacterium lividum. Antimicrob. Agents
Chemother. (2001) 45:837-44.
5. Duez C., Vanhove M., Gallet X., Bouillenne F., Docquier J.D., Brans A., Frère J.-
M. Purification and characterization of PBP4a, a new low-molecular-weight
penicillin-binding protein from Bacillus subtilis. J. Bacteriol. (2001) 183:1595-9.
6. Bebrone C., Moali C., Mahy F., Rival S., Docquier J.D., Rossolini G.M., Fastrez J.,
Pratt R.F., Frère J.M., Galleni M. CENTA as a chromogenic substrate for studying
-lactamases. Antimicrob. Agents Chemother. (2001) 45:1868-71.
7. Docquier J.D., Luzzaro F., Amicosante G., Toniolo A., Rossolini G.M. Emergence
of multidrug-resistant Pseudomonas aeruginosa producing the PER-1 extended-
spectrum serine--lactamase and the VIM-2 metallo--lactamase. Emerg. Infect.
Dis. (2001) 7:910-911.
8. Docquier J.D., Pantanella F., Giuliani F., Thaller M.C., Amicosante G., Galleni M.,
Frère J.M., Bush K., Rossolini G.M. CAU-1, a subclass B3 metallo--lactamase of
low substrate affinity encoded by an ortholog present in the Caulobacter crescentus
chromosome. Antimicrob. Agents Chemother. (2002) 46:1823-30.
9. Vessilier S., Docquier J.D., Rival S., Frère J.M., Galleni M., Amicosante G.,
Rossolini G.M., Franceschini N. Overproduction and biochemical characterization
of the Chryseobacterium meningosepticum BlaB metallo--lactamase. Antimicrob.
Agents Chemother. (2002) 46:1921-27.
10. Lombardi G., Luzzaro F., Docquier J.D., Riccio M.L., Perilli M., Coli A.,
Amicosante G., Rossolini G.M., Toniolo A. Nosocomial infections caused by
multidrug-resistant isolates of Pseudomonas putida producing the VIM-1 metallo-
-lactamase. J. Clin. Microbiol. (2002) 40:4051-4055.
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11. Migliavacca R., Docquier J.D., Mugnaioli C., Amicosante G., Daturi R., Lee K.,
Rossolini G.M.. Pagani, L. Simple microdilution test for detection of metallo--
lactamase production in Pseudomonas aeruginosa. J. Clin. Microbiol. (2002) 40:4388-
4390.
12. Pallecchi L., Docquier J.D., Riccio M.L., Giuliani F., Cresti S., Musmanno R.A.,
Coratza G., Rossolini G.M. Carbapenemases in microbial drug resistance. L'Igiene
Moderna. (2003) 120:285-298.
13. Docquier J.D., Lamottte-Brasseur J., Galleni M., Amicosante G., Frère J.M.,
Rossolini G.M. On functional and structural heterogeneity of VIM-type metallo--
lactamases. J. Antimicrob. Chemother. (2003) 51:257-266.
14. Docquier J.D., Riccio M.L., Mugnaioli C., Luzzaro F., Endimiani A., Toniolo, A.,
Amicosante G., Rossolini G.M. IMP-12, a new plasmid-encoded metallo--
lactamase of the IMP-type from a Pseudomonas putida isolate. Antimicrob. Agents
Chemother. (2003) 47:1522-1528.
15. Riccio M.L., Docquier J.D., Dell’Amico E., Luzzaro F., Amicosante G., Rossolini
G.M. Characterization of a novel 3-N-aminoglycoside acetyltransferase gene,
aac(3)-Ic, from a Pseudomonas aeruginosa integron. Antimicrob. Agents Chemother.
(2003) 47:1746-1748.
16. Forleo C., Benvenuti M., Calderone V., Schippa S., Docquier J.D., Thaller M.C.,
Rossolini G.M., Mangani S. Expression, purification, crystallization and
preliminary X-ray characterization of the class B acid phosphatase (AphA) from
Escherichia coli. Acta Crystallogr. D Biol. Crystallogr. (2003) 59:1058-1060.
17. Luzzaro F., Endimiani A., Docquier J.D., Mugnaioli C., Bonsignori M.,
Amicosante G., Rossolini G.M. Prevalence and characterization of metallo--
lactamases in clinical isolates of Pseudomonas aeruginosa. Diagn. Microbiol. Infect.
Dis. (2004) 48:131-135.
18. Luzzaro F., Docquier J.D., Colinon C., Endimiani A., Lombardi G., Amicosante
G., Rossolini G.M., Toniolo A. Emergence in Klebsiella pneumoniae and Enterobacter
cloacae clinical isolates of the VIM-4 metallo--lactamase encoded by a conjugative
plasmid. Antimicrob. Agents Chemother. (2004) 48:648-650.
19. Docquier J.D., Lopizzo T., Liberatori S., Prenna M., Thaller M.C., Frère J.M.,
Rossolini G.M. Biochemical characterization of the THIN-B metallo--lactamase
of Janthinobacterium lividum. Antimicrob. Agents Chemother. (2004) 48:4778-4783.
20. Riccio M.L., Pallecchi L., Docquier J.D., Cresti S., Catania M.R., Pagani L.,
Lagatolla C., Cornaglia G., Fontana R., Rossolini G.M. Clonal relatedness and
conserved integron structures in epidemiologically unrelated Pseudomonas
aeruginosa producing the VIM-1 metallo--lactamase from different Italian
hospitals. Antimicrob. Agents Chemother. (2005) 49:104-110.
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21. Giuliani F., Docquier J.D., Riccio M.L., Pagani L., Rossolini G.M. OXA-46, a new
class D β-lactamase of narrow substrate specificity, encoded by a blaVIM-1-
containing integron from a Pseudomonas aeruginosa clinical isolate. Antimicrob.
Agents Chemother. (2005) 49:1973-1980.
22. Pagani L., Colinon C., Migliavacca R., Labonia M., Docquier J.D., Nucleo E.,
Spalla M., Li Bergoli M., Rossolini G.M. Nosocomial outbreak caused by
multidrug-resistant Pseudomonas aeruginosa producing the IMP-13 metallo-β-
lactamase. J. Clin. Microbiol. (2005) 43:3824-3828.
23. Lee K., Yum J.H., Yong D., Lee H.M., Kim H.D., Docquier J.D., Rossolini G.M.,
Chong Y. A novel acquired Metallo-β-lactamase gene, blaSIM-1, in a class 1 integron
from Acinetobacter baumannii clinical isolates from Korea. Antimicrob. Agents
Chemother. (2005) 49:4485-4491.
24. Stoczko M., Frère J.M., Rossolini G.M., Docquier J.D. Post-genomic scan of
metallo-β-lactamase homologues in Rhizobacteria: identification and
characterization of BJP-1, a subclass B3 ortholog from Bradyrhizobium japonicum.
Antimicrob. Agents Chemother. (2006) 50:1973-1981.
25. Voha C., Docquier J.D., Rossolini G.M., Fosse T. Genetic and biochemical
characterization of FUS-1 (OXA-85), a narrow-spectrum class D β-lactamase from
Fusobacterium nucleatum subsp. polymorphum. Antimicrob. Agents Chemother. (2006)
50:2673-2679.
26. Rossolini G.M., Docquier J.D. New β-lactamases: a paradigm for the rapid
response of bacterial evolution in the clinical setting. Future Microbiology (2006)
1:295-308.
27. Zeba B., Kiendrébeogo M., Lamien A., Docquier J.D., Simporé J., Nacoulma O.G.
Major enzymatic factors involved in bacterial penicillin resistance in Burkina
Faso. Pak. J. Biol. Sci. (2007) 10:506-510.
28. Cornaglia G., Akova M., Amicosante G., Canton R., Cauda R., Docquier J.D.,
Edelstein M., Frère J.M., Fuzi M., Galleni M., Giamarellou H., Gniadkowski M.,
Koncan R., Libisch B., Luzzaro F., Miriagou V., Navarro F., Nordmann P., Pagani
L., Peixe L., Poirel L., Souli M., Tacconelli E., Vatopoulos A., Rossolini G.M.
Metallo-β-lactamases as emerging resistance determinants in Gram-negative
pathogens: open issues. Int. J. Antimicrob. Agents (2007) 29:380-388.
29. Rossolini G.M., Mantengoli E., Docquier J.D., Musmanno R., Coratza G.
Epidemiology of infections caused by multiresistant gram-negatives: ESBLs,
MBLs, panresistant strains. New Microbiol. (2007) 30:332-339.
30. Perilli M., Caporale B., Celenza G., Pellegrini C., Docquier J.D., Mezzatesta M.,
Rossolini G.M., Stefani S., Amicosante G. Identification and characterization of a
new metallo-β-lactamase, IND-5, from a clinical isolate of Chryseobacterium
indologenes. Antimicrob. Agents Chemother. (2007) 51:2988-2990.
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31. Garcia-Saez I., Docquier J.D., Rossolini G.M., Dideberg O. The three-dimensional
structure of VIM-2, a Zn-β-lactamase from Pseudomonas aeruginosa in its reduced
and oxidised form. J. Mol. Biol. (2008) 375:604-611.
32. Cagnacci S., Gualco L., Roveta S., Mannelli S., Borgianni L., Docquier J.D., Dodi
F., Centanaro M., Debbia E., Marchese A., Rossolini G.M. Bloodstream infections
caused by multidrug-resistant Klebsiella pneumoniae producing the carbapenem-
hydrolysing VIM-1 metallo-β-lactamase: first Italian outbreak. J. Antimicrob.
Chemother. (2008) 61:296-300.
33. Michaux C., Massant J., Kerff F., Frère J.M., Docquier J.D., Vandenberghe I.,
Samyn B., Pierrard A., Feller G., Charlier P., Van Beeumen J., Wouters J. Crystal
structure of a cold-adapted class C β-lactamase. FEBS J. (2008) 275:1687-1697.
34. Gori Savellini G., Di Genova G., Terrosi C., Di Bonito P., Giorgi C., Valentini M.,
Docquier J.D., Cusi M.G. Immunization with Toscana virus N-Gc proteins
protects mice against virus challenge. Virology (2008) 375:521-528.
35. Stoczko M., Frère J.M., Rossolini G.M., Docquier J.D. Functional diversity among
metallo-β-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora.
Antimicrob. Agents Chemother. (2008) 52:2473-2479.
36. Docquier J.D., Calderone V., De Luca F., Benvenuti M., Giuliani F., Bellucci L.,
Tafi A., Nordmann P., Botta M., Rossolini G.M., Mangani S. The crystal structure
of the OXA-48 β-lactamase reveals mechanistic diversity among class D
carbapenemases. Chem. Biol. (2009) 16:540-547.
37. Zeba B., De Luca F., Dubus A., Delmarcelle M., Simporé J., Nacoulma O.J.,
Rossolini G.M., Frère J.M., Docquier J.D. Characterization of IND-6, a highly
divergent IND-type metallo-β-lactamase from Chryseobacterium indologenes strain
597 isolated in Burkina Faso. Antimicrob. Agents Chemother. (2009) 53:4320-4326.
38. Poirel L., Docquier J.D., De Luca F., Verlinde A., Ide L., Rossolini G.M.,
Nordmann P. BEL-2, an expanded-spectrum β-lactamase with increased activity
toward expanded cephalosporins in Pseudomonas aeruginosa. Antimicrob. Agents
Chemother. (2010) 54:533-535.
39. De Luca F., Giraud-Morin C., Rossolini G.M., Docquier J.D., Fosse T. Genetic and
biochemical characterization of TRU-1, the endogenous class C β-lactamase from
Aeromonas enteropelogenes. Antimicrob. Agents Chemother. (2010) 54:1547-1554.
40. Docquier J.D., Benvenuti M., Calderone V., Giuliani F., Kapetis D., De Luca F.,
Rossolini G.M., Mangani S. Crystal structure of the narrow-spectrum OXA-46
class D β-lactamase: relationship between active site lysine carbamylation and
inhibition by polycarboxylates. Antimicrob. Agents Chemother. (2010) 54:2167-74.
41. Borgianni L., Vandenameele J., Matagne A., Bini L., Bonomo R.A., Frère J.M.,
Rossolini G.M., Docquier J.D. Mutational analysis of VIM-2 reveals an essential
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determinant for metallo-β-lactamase stability and folding. Antimicrob. Agents
Chemother. (2010) 54:3197-3204.
42. Lee K., Kim C.K., Hong S.G., Choi J., Song S., Koh E., Yong D., Jeong S.H., Yum
J.H., Docquier J.D., Rossolini G.M., Chong Y. Characteristics of clinical isolates of
Acinetobacter genomospecies 10 carrying two different metallo-β-lactamases. Int. J.
Antimicrob. Agents (2010) 36:259-63.
43. Docquier J.D., Benvenuti M., Calderone V., Stoczko M., Menciassi N., Rossolini
G.M., Mangani S. High-resolution crystal structure of the subclass B3 BJP-1
metallo-β-lactamase: rational basis for substrate specificity and interaction with
sulfonamides. Antimicrob. Agents Chemother. (2010) 54:4343-4351.
44. Lee K., Kim C.K., Yong D., Jeong S.H., Yum J.H., Seo Y.H., Docquier J.D., Chong
Y. Improved performance of the modified Hodge test with MacConkey agar for
screening carbapenemase-producing Gram-negative bacilli. J. Microbiol. Methods
(2010) 83:149-152.
45. Santella G., Pollini S., Docquier J.D., Mereuta A. I., Gutkind G., Rossolini G.M.,
Radice M. Intercontinental dissemination of IMP-13-producing Pseudomonas
aeruginosa belonging in Sequence Type 621. J. Clin. Microbiol. (2010) 48:4342-4343.
46. Borgianni L., Prandi S., Salden L., Santella G., Hanson N.D., Rossolini G.M.,
Docquier J.D. Genetic context and biochemical characterization of the IMP-18
metallo-β-lactamase identified in a Pseudomonas aeruginosa isolate from the United
States. Antimicrob. Agents Chemother. (2011) 55:140-145.
47. Santella G., Docquier J.D., Gutkind G., Rossolini G.M., Radice M. Purification
and biochemical characterization of IMP-13 metallo-β-lactamase. Antimicrob.
Agents Chemother. (2011) 55:399-401.
48. Lassaux P., Traoré A.D.K., Loisel E., Favier A., Docquier J.D., Sohier J.S., Laurent
C., Bebrone C., Frère J.M., Ferrer J.L., Galleni M. Structural and biochemical
characterization of the subclass B1 metallo-β-lactamase VIM-4. Antimicrob.
Agents Chemother. (2011) 55:1248-1255.
49. Docquier J.D., Benvenuti M., Calderone V., Rossolini G.M., Mangani S. The
crystal structure of the extended spectrum β-lactamase TEM-72 inhibited by
citrate. Acta Crystallogr. F Struct. Biol. Cryst. Commun. (2011) F67:303-306.
50. Lee K., Yum J.H., Yong D., Jeong S.H., Rossolini G.M., Docquier J.D., Chong Y.
Biochemical characterization of the TEM-107 extended-spectrum β-lactamase in a
Klebsiella pneumoniae isolate from Korea. Antimicrob. Agents Chemother. (2011)
55:5930-5932.
51. De Luca F., Benvenuti M., Carboni F., Pozzi C., Rossolini G.M., Mangani S.,
Docquier J.D. Evolution to carbapenem-hydrolyzing activity in
noncarbapenemase class D β-lactamase OXA-10 by rational protein design. Proc.
Natl. Acad. Sci. U S A. (2011) 108:18424-18429.
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52. Gualdi L., Kaur Hayre J., Gerlini A., Bidossi A., Colomba L., Trappetti C., Pozzi
G., Docquier J.D., Andrew P.W., Ricci S., Oggioni M.R.. Regulation of
neuraminidase expression in Streptococcus pneumoniae. BMC Microbiol. (2012)
12:200.
53. Kaur Hayre J., Xu G., Borgianni L., Taylor G.L., Andrew P.W., Docquier J.D.,
Oggioni M.R. Optimization of a direct spectrophotometric method to investigate
the kinetics and inhibition of sialidases. BMC Biochem. (2012) 13:19.
54. Pollini S., Maradei S., Pecile P., Olivo G., Luzzaro F., Docquier, J.D., Rossolini
G.M. FIM-1, a new acquired metallo-β-lactamase from a Pseudomonas
aeruginosa clinical isolate from Italy. Antimicrob. Agents Chemother. (2013)
57:410-416.
55. Lahiri S., Mangani S., Durand-Reville T., Benvenuti M., De Luca F., Sanyal G.,
Docquier J.D. Structural insight into potent broad-spectrum inhibition with
reversible recyclization mechanism: Avibactam in complex with CTX-M-15 and
Pseudomonas aeruginosa AmpC β-lactamases. Antimicrob. Agents Chemother.
(2013) 57:2496-2505.
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Capitoli di libri scientifici
1. Rossolini G.M., Docquier J.D. Class B -lactamases. p. 115-144. In “Resistance to
Antibiotics : Enzyme-Mediated Mechanisms and Prospects for Inhibition”, by M.
Tolmasky et R.A. Bonomo, editors. ASM Press, Washington, U.S.A. (2007).
2. Docquier J.D., Rossolini G.M., Nikaido H., Frère J.M. Interplay between beta-
lactamase activity, outer membrane and active efflux system. Chapter 16. In “β-
lactamases”, by J.M. Frère, editor. Nova Science Publishers, Hauppauge, USA
(2011).