curriculum vitae matthias h. tschÖp, m.d. · 5 cv matthias h. tschöp, m.d. adhoc reviewer, german...

CV Matthias H. Tschöp, M.D. 1

OFFICES Helmholtz Zentrum München Institute for Diabetes and Obesity Business Campus Garching Parkring 13 85748 Garching, Germany

Technische Universität München Klinikum rechts der Isar Schneckenburger Strasse 8 81675 Munich

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WEBSITES www.helmholtz-muenchen.de/hdc www.helmholtz-muenchen.de/ido www.professoren.tum.de/tschoep-matthias

CURRICULUM VITAE MATTHIAS H. TSCHÖP, M.D. Research Director, Helmholtz Diabetes Center Director, Institute for Diabetes and Obesity, Helmholtz Zentrum München Chair, Metabolic Diseases, Technische Universität München ACADEMIC EMPLOYMENT 2012-present Yale University (USA) Adjunct Professor 2012-present Technische Universität München (Germany) Alexander von Humboldt Professor & Chair, Division of Metabolic Diseases Professor of Medicine 2011-present Helmholtz Diabetes Center Research Director Helmholtz Zentrum München / German Research Center for Environmental Health (Germany) Director, Institute for Diabetes and Obesity 2010-2011 University of Cincinnati (USA) Arthur Russell Morgan Chair of Medicine 2009-2011 University of Cincinnati (USA) Research Director, Cincinnati Diabetes & Obesity Centre, College of Medicine 2009-present University of Cincinnati (USA) Professor, Institute for Metabolic Disease, Division of Endocrinology, Diabetes & Metabolism, College of Medicine (adjunct Professor since 2011) 2003-2009 University of Cincinnati (USA) Associate Professor, Departments of Psychiatry & Medicine, Obesity Research Center & Genome Research Institute (Tenure since 2007)


2002-2003 German Institute of Human Nutrition, Potsdam-Nuthetal (Germany) Senior Scientist, Department of Pharmacology 1999-2002 Eli Lilly and Co., Indianapolis, (USA) Postdoctoral Scientist, Discovery Research 1995-1999 Ludwig-Maximilians University, Munich (Germany) Innenstadt University Hospital Research Fellow, Neuroendocrine Unit 1995-1999 Ludwig-Maximilians University, Munich (Germany) Innenstadt University Hospital Resident, Department of Internal Medicine EDUCATION 1998 Ludwig-Maximilians-University, Munich (Germany) Thesis: Development and clinical application of a non-isotopic method for the quantification of salivary testosterone 1987-1994 Ludwig-Maximilians-University, Munich (Germany) Pre-medical and medical school, internship in internal medicine, surgery and psychiatry Doctor of Medicine, magna cum laude 1983-1999 Red Cross Service Bavarian Mountain Guard (1998-1999 as emergency physician) 1986-1987 Military service 1. Bavarian Alpine Division 1977-1986 Oscar-von-Miller Gymnasium, Munich AWARDS AND HONORS Elected Member, German National Academy of Science (Leopoldina) 2013 Werner-Creutzfeld-Award of the German Diabetes Society 2012 Recognizes achievements in research on diabetes pathophysiology and therapy Alexander von Humboldt Professorship, 2012 Highest endowed German research award, first and only physician to receive this award Outstanding Scientific Achievement Award, American Diabetes Association, 2011 Recognizes research in diabetes that demonstrates particular independence of thought and


originality, awarded annually to one nominee worldwide up to the age of 50 years NIH/NIDDK 60th Anniversary Scholar Award, 2010 Recognizes achievements that exemplify excellence in medical research funded or supported by the NIDDK. Nominated by the National Institute for Obesity Research André Mayer Award, Int. Association for the Study of Obesity (IASO) 2010 Recognizes worldwide outstanding research in the field of obesity Elected Member, The American Society for Clinical Investigation (ASCI) 2009 Scientific Achievement Award, The Obesity Society (TOS/NAASO) 2007 Recognizes excellence in an established research career in obesity research Christina Barz Award of the German Society for Psychiatry, Neurology and Psychosomatic Medicine 2007 Award for outstanding contributions in the field of bulimia and anorexia nervosa research Young Investigator Award, European Neuroendocrine Association (ENEA), 2002 Schoeller-Junkmann Award of the German Endocrine Society (DGE) 2001; Annual award for outstanding scientific achievement in endocrinology Lilly Research Laboratories President‘s Award, 2000 Eli Lilly Endocrine Research Award for Science, 2000 Selected “Hot Paper” by The Scientist, for Tschöp M et al., Nature 2000. 407:908-13. (to date cited > 2900 times) and for Tschöp M et al., Diabetes 2001. 50:707-9 (to date cited > 1500 times) Media Presence (selected): Coverage of scientific work and interviews in Time Magazine, Scientific American, New York Times, New York Times Magazine, Washington Post, The Scientist, The New Scientist, Der Spiegel, Frankfurter Allgemeine Zeitung, Die Zeit, Focus-Diabetes, BR-alpha, BR2, SWR2 Campus. SELECTED ACADEMIC SERVICE Organizer/Chair/Director Organizer: EMBO/EMBL Symposium: Translating Diabetes (Heidelberg, 2014) Chair and Organizer: 1st Annual Helmholtz-Nature Medicine Diabetes Conference (2013) and organizer of the 2nd and 3rd Annual Helmholtz-Nature Medicine Diabetes Conference (2014 and 2015) Chair and Organizer: 1st Annual Meeting of the Helmholtz Alliance “ICEMED – Imaging and Curing Environmental Metabolic Diseases” (2013) Chair and Organizer: Keystone Obesity Symposium 2013: Neural Control of Body Weight Organizer and Chair of EMBL Conference on Diabetes and Obesity, Heidelberg, 2012 Chair of numerous national and international Scientific Sessions including: The Endocrine Society 2004, American Diabetes Association 2005 & 2006, NAASO/TOS 2005, 2006,


Keystone Obesity & Diabetes Meeting 2005, 2006 & 2007 and FASEB 2011. Chair and Organizer: Cincinnati Obesity and Diabetes Center of Excellence (CDOC), Annual Retreat 2010 and 2011 Director: Graduate Course, Neuroendocrinology, Neuroscience Graduate Program University of Cincinnati College of Medicine (2005 - present) Associate Director, NIH Mouse Metabolic Phenotyping Center, University of Cincinnati, Metabolic Diseases Institute, (2004 - present) Associate Director, Mouse Behavioral Core, University of Cincinnati Metabolic Diseases Institute (2004 - 2009) Chair, Basic Research Steering Committee, Diabetes and Obesity Center of Excellence, University of Cincinnati & Cincinnati Children’s Hospital Member Member, Helmholtz Think Tank (since 2013) Member, TUM IAS Institute for Advanced Studies (since 2013) Member, NIH-NIDDK Study Section IPOD (Integrated Physiology of Diabetes and Obesity) (2010-2013) Member, Institutional Animal Care and Use Committee (IACUC) Univ. Cincinnati (2006 - 2011) Member, Scientific Advisory Board, International Conference on Awareness of Obesity and Diabetes, Athens, Greece (October 2010) Member, Grant Review Panel, Davis Foundation for Eating Disorder Research (2009 - 2012) Steering Committee Member, SME-advisor and Neuroscience Coordinator European Commission Framework Program 6: “New Drug Targets for Diabesity” (2003 - 2008) Consultant Consultant, NIH PPG, Iowa University Cardiovascular Research Centre Consultant, Obesity & Metabolism Research Center, University of Alabama Reviewer Ad-Hoc Reviewer & Consultant, Spanish Government, Ministry of Health Reviewer NIH-NIDDK, Integrated Physiology of Obesity and Diabetes (IPOD) Special Emphasis panel and challenge grants (2009) Reviewer NIH-NIDDK, Special Emphasis Panel on Obesity and Diabetes (2/2008, 10/2008)


AdHoc Reviewer, German Research Council (DFG) (2007-present) Reviewer NIH-NIDDK, Study Section: Diabetes, Endocrinology, and Metabolic Diseases Study Section B (3/2006) Reviewer NIH-NIDDK, Study Section: Clinical and Integrative Diabetes and Obesity (CIDO) (10/2006) Reviewer, American Diabetes Association (ADA) Abstracts & Research Grants, (2005-2011) Reviewer, The Obesity Society (TOS) Abstracts & Research Grants, (2004 – present) Ad-Hoc Reviewer, The Wellcome Trust, London UK Reviewer, Pilot and Feasibility Program, Diabetes Centre, University of Michigan Reviewer, Pilot and Feasibility Program, Division of Endocrinology & Metabolism, University of Pennsylvania Reviewer, Pilot and Feasibility Program, Diabetes Centre, Cincinnati, Children’s Hospital. Other Mentor: Experimental Design, Pharmacology, Diabetes, Endocrinology, Neuroscience and Physiology of Graduate Students, Research Assistants, Postdoctoral Fellows and Group leaders, Metabolic Diseases, Technische Universtität München and Helmholtz Diabetes Center at Helmholtz Zentrum München (2012-ongoing) Member of the Animal Protection Committee of the regional government of Upper Bavaria (starts June 1, 2014) Lecturer: Interdisciplinary Graduate Course Emerging Concepts in Targeting Common Metabolic Disorders (2009-present) Scientific Advisor for the International Prader-Willi Alliance for Research (2003-present) Mentor: Experimental Design, Pharmacology, Diabetes, Endocrinology and Physiology of Undergraduate & Graduate Students, Research Assistants, Postdoctoral Fellows and Junior Faculty, Metabolic Disease Institute, University of Cincinnati (2003-2012) CONSULTING AND SCIENCTIFIC ADVISORY BOARD MEMBERSHIPS Consultant, Böhringer Ingelheim Pharma GmbH & Co. KG (2013) Consultant, Bionorica SE (2013) Consultant, Roche Pharmaceuticals, Basel, Switzerland (2011-2012) Drug Discovery Advisory Board, Forest Research Laboratories (2010) Scientific Advisory Board Member, DiaLean Biotech, New Jersey (2010)


Scientific Advisory Board Member, Acylin Biotech, Boston, MA, US (2009-2012) Scientific Advisor, Zydus Cadilla Pharm., Ahmedabad, India (2009-2011) Scientific Advisor, Diabetes and Obesity, Takeda Pharm., Chicago, USA (2009-2010) Scientific Advisor, Ambrx Pharmaceuticals, San Diego, CA, US, (2008-present) Scientific Advisor, Novartis Pharm., Boston, USA, (2007) Scientific Advisory Board Member, Marcadia Biotech, Carmel, IN (2006-2010) Scientific Advisory Board Member, Elixir Pharmaceuticals, Boston, MA, US (2004-2010) Consultant, Beckmann-Diagnostic Systems Laboratories (DSL), Webster, TX, US (2004-2007) Consultant, DOV Pharmaceuticals, NYC, NY, US, (2004-2007) Consultant, Biomeasure/Ipsen Inc., Boston, MA, US, (2003-2008) EDITOR FOR SCIENTIFIC JOURNALS AND TEXTBOOKS Molecular Metabolism (2012-ongoing, Founding Editor in Chief) Diabetes (Editorial Board Member, 2012-ongoing) Frontiers of Endocrinology (Associate Editor 2011-2012) Adipocyte (Editorial Board Member, 2011-ongoing) Reviews in Endocrine and Metabolic Disorders, Guest Editor (2010/11) PLoS Genetics (Guest Editor, 2010-ongoing) J Clin Invest (Consulting Editor, Editorial Board Member, 2009-2012) Am J Physiol Endocrinol Metab (Editorial Board Member 2007-2011) Obesity Facts (Associate Editor, 2007-2012) Endocrinology (Editorial Board Member, 2005-2008) European Journal of Endocrinology (Associate Editor 2005-2012) Obesity & Metabolism (Associate Editor, 2005-2010) Editor, Online Obesity Textbook: www.obesitext.com (2004-2011) REVIEWER FOR SCIENTIFIC JOURNALS (SELECTED EXAMPLES) eLIFE Nature Science Cell Science Translational Medicine Nature Medicine Cell Metabolism New England Journal of Medicine The Lancet Journal of Clinical Investigation Nature Neuroscience Nature Reviews Neuroscience Nature Communications Cell Reports


PNAS JAMA PLOS Medicine Aging Cell Diabetes Gastroenterology Journal of Neuroscience Endocrinology Obesity American Journal of Physiology Molecular Endocrinology International Journal of Obesity Journal of Clinical Endocrinology and Metabolism Clinical Endocrinology The Journal of Endocrinology The Journal of Neuroendocrinology Molecular Biology of the Cell American Journal of Clinical Nutrition Diabetologia Journal of Internal Medicine Nature Reviews Endocrinology Annals of Medicine The Journal of Cell Biology SOCIETY MEMBERSHIPS American Diabetes Association (ADA) American Society for Clinical Investigation (ASCI) The Obesity Society (TOS/NAASO) The Endocrine Society (ES) The European Neuroendocrinology Association (ENEA) Society for the Study of Ingestive Behavior (SSIB) German Endocrine Society (DGE) German Diabetes Society (DDG) NOTABLE INVITED LECTURES (SELECTED OUT OF <200) Rockefeller University: 20 Years of Leptin Discovery, NYC, Symposium 2014 ICE/Endocrine Society Meeting, Chicago, 2014 EMBO/EMBL Conference: Translating Diabetes, Heidelberg 2014 Sanford/Burnham Scientific Symposium: Metabolic Origins of Disease, Orlando 2014 IASO 12th International Conference on Obesity, Kuala-Lumpur 2014 Nature Medicine Conference: Novel Therapies in Diabetes and Obesity, Madrid, 2014 IR2013 Symposium, Barcelona, 2013 4th Annual Symposium ITMO Circulation, Metabolism, Nutrition, Paris, 2013 Helmholtz Jahrestagung, Berlin, 2013 IDEA Summit, Lund/Sweden, 2013 36th Naito Conference, Sapporo/Hokkaido, Japan, 2013 FENS/IBRO Summer School, Prato/Italy, 2013 Cell Symposium: Immunometabolism: From Mechanisms to Therapy, Toronto, 2013 Cell Symposium: CNS Control of Food Intake, Boston, 2013 Keystone Symposium: Neuronal Control of Appetite, Metabolism and Weight, Banff, 2013 The Endocrine Society Annual Meeting, San Francisco, 2012 European Association for the Study of Diabetes (EASD), Berlin, 2012


International Congress of Endocrinology, Florence, 2012 Principles of Innate Immunity, Schloss Ellmau Conference, Austria, 2012 NIH/NIDDK, Leptin Resistance Workshop, Bethesda/Washington DC. 2011 The Ramanbhai Foundation, 4th Int. Symposium, Ahmedabad, India, 2011 International Bariatric Surgery Meeting, Brazil, 2011 International Obesity Conference “The Obese Species”, Sicily, 2011 Harvard Medical School, Childrens Hospital, Endocrine Grand Rounds, Boston 2011 Int. Foundation Obesity Conference: “ The Obese Species”, Sicily, Italy, 2011 European Society for Endocrinology (ESE), Zyprus, Greece, 2011 Int. Diabetes Foundation (IDF), Dubai, 2011 Harvard Medical School, Jocelyn Diabetes Centre, Boston 2011 Mt. Sinai Hospital, University of Toronto, Toronto, Canada, 2010 International Society for Neuroendocrinology, Rouen, France, 2010 American Diabetes Association, Orlando, FL, 2010 International Congress of Obesity (ICO), Stockholm, Sweden, 2010 The Obesity Society, San Diego, CA, 2010 Int. Foundation Obesity & Diabetes Conference, Athens, Greece, 2010 National Obesity Conference, Jackson, Mississippi, 2010 Northwestern University, Obesity Centre, Chicago, IL, 2010 University of Washington, Diabetes Seminar, Seattle, 2010 German Obesity and Diabetes Conference, DAG, Berlin, 2010 Keystone Obesity Meeting, Keystone, Colorado, 2009 The Ramanbhai Foundation 4th Int. Symp, Ahmedabad, India, 2009 Mount Sinai Hospital New York, Diabetes & Endocrinology Division, 2009 2nd USC Childhood Obesity Research Conference, Los Angeles, CA, 2009 Royal Academy of the Netherlands, Amsterdam, 2009 Annual American Peptide Conference, Bloomington, IN, 2009 New York University, Dept. of Medicine, Grand Rounds NYC, 2009 Gordon Conference on CNS Cannabinoid Function, Biddeford, ME, 2009 ETH Zurich, Institute of Animal Sciences, Switzerland, August 2009 Cornell University, Dept. of Medicine, NYC, October 2009 University of Colorado, Depts. of Medicine & Physiology, Denver, CO, 2009 New York Academy of Science, NYC, Dec. 11 2008 Centennial ASPET Conference, FASEB 2008, San Diego, CA, 2008 The Endocrine Society 2008, San Francisco, CA, 2008 University of Southern California, Dept. of Physiology, 2008 Columbia University, Naomie Berrie Diabetes Centre, New York, NY, 2007 University of Michigan, Diabetes Centre, Ann Arbor, MI, 2007 John B. Pierce Laboratories, Yale University, New Haven, CT, 2007 Australian Neuroendocrine Assoc., Christ Church, New Zealand, 2007 The Obesity Society, Lilly Award Lecture, New Orleans, 2007 University of Cambridge, Diabetes Centre, Cambridge, UK, September 2007 Keystone Symposium, Gut Hormones, Santa Fe, NM, 2006 FASEB Meeting, San Francisco, CA, 2006 American Heart Association, Annual Meeting, Chicago, Illinois, 2006 University of Pennsylvania, Diabetes Centre, Philadelphia, PA, 2005 University of Calif. San Francisco, Diabetes Centre, San Francisco, CA, 2005 University of Washington, Washington, Seattle, 2005 Columbia University, Naomie Berrie Diabetes Centre, New York, NY, 2005 American Diabetes Association, San Diego, CA, 2005 Ernst Klenk Symposium Molecular Medicine, Cologne, Germany 2005 Int. Congress of Endocrinology (ICE), Lissabon, Portugal, 2004 The Endocrine Society, New Orleans, LA 2004 FASEB Experimental Biology Conference, Washington DC, 2004 BIDMC Grand Rounds, Harvard Medical School, Boston, MA 2004 University of Chicago, Department of Endocrinology, Chicago, IL, 2004


Society for Neuroendocrinology, New Orleans, LA, 2004 European Congress of Endocrinology, Lyon, France, 2003 Dept. of Neuroscience, Karolinska Institute, Stockholm, Sweden, 2003 Int. Conf on Energy Balance, Hammersmith Hospital, London, UK, 2003 The Obesity Society, Ft. Lauderdale, FL, 2003 European Neuroendocrine Association, Munich, Germany, 2002 Dept. of Neurobiology, Yale Medical School, New Haven, CT, USA, 2002 Keystone Obesity Meeting, Taos, NM, 2001 European Congress of Endocrinology, Turin, Italy, 2001 Mount Sinai School of Medicine, New York, NY, 2001 International Congress of Endocrinology (ICE) Sydney, Australia, 2000 RECENT PUBLICATIONS (OUT OF > 240; H-FACTOR 54) Tschöp M, Strasburger CJ, Hartmann G, Biollaz J, Bartsch P. Raised leptin concentrations at high altitude associated with loss of appetite. Lancet 1998;352(9134):1119-20. (IF 38) Tschöp M, Smiley D, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000;407(6806):908-13. (IF 36) Tschöp M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes 2001;50(4):707-9. (IF 8.3) Ravussin E, Tschöp M, Morales S, Bouchard C, Heiman ML. Plasma ghrelin concentration and energy balance: overfeeding and negative energy balance studies in twins. J Clin Endocrinol Metab 2001;86(9):4547-51. (IF 6.2) Horvath TL, Diano S, Heiman ML, Tschöp M. Ghrelin and the regulation of energy balance: A hypothalamic perspective. Endocrinology 2001;142(10):4163-9. (IF 4.5) Tschöp M, Wawarta R, Riepl RL, Friedrich S, Bidlingmaier M, Landgraf R, Folwaczny C. Post-prandial decrease of circulating human ghrelin levels. J Endocrinol Invest. 2001 Jun;24(6):RC19-21. (IF 1.6) Tschöp M, Statnick M, Suter T, Heiman ML. Growth hormone-releasing peptide- 2 (GHRP-2) increases fat mass in mice lacking neuropeptide Y (NPY): Indication for a crucial mediating role of hypothalamic Agouti-related protein (AGRP). Endocrinology 2002;143(2):558-68. (IF 4.5) Wu Z, Bidlingmaier M, Liu C, De Souza EB, Tschöp M, Morrison KM, Strasburger CJ. Quantification of the soluble leptin receptor in human blood by ligand-mediated immunofunctional assay. J Clin Endocrinol Metab 2002;87(6):2931-9. (IF 6.2) Ukkola O, Ravussin E, Jacobson P1, Pérusse L, Rankinen T, Tschöp M, Heiman ML, Leon AS, Rao DC, Skinner J, Wilmore JH, Sjöstrom L, Bouchard C. Role of ghrelin polymorphisms in obesity. Results from the Quebeck family study, heritage family study and Swedish obese subjects study. Obes Res 2002;10(8):782-91. (IF 4.95) Tschöp M, Flora DB, Mayer JP, Heiman ML. Hypophysectomy prevents ghrelin- induced adiposity and increases gastric ghrelin secretion in rats. Obesity 2002;10(10):991-9. (IF 4.3) DelParigi A, Tschöp M, Heiman ML, Salbe A, Bunt J, Vozarova B, Sell SM, Tataranni PA. High circulating ghrelin: a potential cause for hyperphagia and obesity in Prader-Willi Syndrome. J Clin Endocrinol Metab 2002;87(12):5461-4. (IF 6.2)


Pagotto U, Gambineri A, Vicennati V, Heiman ML, Tschöp M, Pasquali R. Plasma ghrelin, obesity and the polycystic ovary syndrome: Correlation with insulin resistance and androgen levels. J Clin Endocrinol Metab 2002;87(12):5625-9. (IF 6.2) Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, Friedman JM, Liu H, Pinto S, Colmers WF, Cone RD, Horvath TL. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 2003;37(4):649-61. (IF 14.7) Cota D, Marsicano G, Tschöp M, Gruebler Y, Schubert M, Auer D, Thoene- Reinecke D, Ortmann S, Flachskamm C, Cervino C, Linthorst A, Pasquali R, Stalla GK, Lutz B, Pagotto U. Peripheral and central mechanisms of action of the endocannabinoid system in energy balance regulation. J Clin Invest 2003;112(3):423-31. (IF 13.1) Bunt JC, Salbe AD, Tschöp M, DelParigi A, Tataranni. PA Relationship of Ghrelin with Anthropometry, Insulin, and Maternal Diabetes Status in Prepubertal Pima Indian children. J Clin Endocrinol Metab 2003;88(8):3756-61. (IF 6.2) Pagotto U, Gambineri A, Pelusi C, Genghini S, Cacciari M, Otto B, Castaneda T, Tschöp M, Pasquali R. Testosterone Replacement Therapy Restores Normal Ghrelin in Hypogonadal Men. J Clin Endocrinol Metab 2003;88(9):4139-43. (IF 6.2) Meyer C, Korthaus K, Jagla W, Cornali E, Grosse J, Fuchs H, Klingenspor M, Roemheld S, Tschöp M, Heldmaier G, Hrabé de Angelis M, Nehls M. A missense mutation in the GH gene causes semidominant dwarfism and obesity in the mouse. Endocrinology 2004;145(5):2531-41. (IF 4.5) van der Lely AJ, Tschöp M, Heiman ML, Ghigo E. Biological, Physiological, Pathophysiological and Pharmacological Aspects of Ghrelin. Endocr Rev 2004;25(3):426-57. (IF 19.9) Salbe AD, Tschöp M, DelParigi A, Venti, C, Tataranni, PA. Paradoxical negative relationship between fasting plasma ghrelin concentrations and ad libitum food intake. J Clin Endocrinol Metab 2004;89(6):2951-6. (IF 6.2) Teff K, Kieffer TJ, D’Allessio D, Tschöp M, Heiman ML, Elliott S, Rader D,Townsend R, Keim NL, Havel PJ. Consuming High-Fructose Beverages with Meals Fails to Suppress Ghrelin Secretion, Delays Postprandial Peaks of Glucose-Dependent Insulinotropic Polypeptide (GIP) and Prolongs Glucagon- Like Peptide-1 (GLP-1) Responses in Normal Weight Women. J Clin Endocrinol Metab 2004;89(6):2963-72. (IF 6.2) Tang-Christensen M, Ortmann S, Bidlingmaier M, Tschöp M. Ghrelin induces long lasting changes in physical activity and food intake. Endocrinology 2004;145(10):4645-52. (IF 4.5) Tschöp M, Castañeda TR, Joost HG, Thöne-Reineke C, Klaus S, Hagan MM, Chandler PC, Oswald KD, Benoit SC, Seeley RJ, Kinzig KP, Moran T, Beck- Sickinger AG, Koglin N, Rodgers RJ, Blundell JE, Ishii Y, Beattie AH, Holch P, Allison DB, Ortmann S, Birringer M, Kreuzer O, Schindler M, Arndt K, Rudolf K, Mark M, Raun K, Madsen K, Wulff BS, Stidsen CE, Datta R, Halem H, Dong J, Taylor J, Culler M, Craney S, Flora D, Smiley D, Heiman ML. Does gut hormone PYY(3-36) regulate food intake? Nature 2004;430(6996):165-67. (IF 36) Helmling S, Maasch C, Eulberg D, Buchner K, Schraeder W, Lange C, Vonhoff S, Wlotzka B, Tschop M, Rosewicz S, Klussmann S. Inhibition of ghrelin action in vitro and in vivo by an RNA-Spiegelmer. Proc Natl Acad Sci U S A 2004;101(36):13174-9. (IF 9.7)


Proulx K, Cota D, Castañeda TR Tso P, Tschöp M, Woods SC, Seeley RJ. Mechanisms of oleoylethanolamide (OEA)-induced changes in feeding behavior and motor activity. Am J Physiol Regul Physiol 2005;289(3):R729-37. (IF 3.5) Benoit S & Tschöp M. How to monkey around with PYY. Am J Physiol Regul Physiol 2005;288(2):R358-9. (IF 3.5) Nogueiras R & Tschöp M. Separation of conjoint hormones yields appetite rivals. Science 2005;310(5750):985-6. (IF 31) Juergens H, Haass W, Castaneda TR, Schuermann A, Dombrowski F, Spranger J, Ristow M, Nawrocki A, Scherer P, Joost HG, Havel PJ, Tschöp M. Ad libitum consumption of fructose containing beverages increases body fat mass in mice. Obesity 2005;13(7):1146-56. (IF 4.3) Spranger J, Verma S, Gohring I, Bobbert T, Seifert J, Sindler AL, Pfeiffer A, Hileman SM, Tschöp M, Banks WA. Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells. Diabetes 2006;55(1):141-7. (IF 8.3) Biebermann H, Castaneda TR, van Landeghem F, von Deimling A, Escher F, Brabant G, Hebebrand J, Hinney A, Tschöp M, Gruters A, Krude H. A role for beta-melanocyte-stimulating hormone in human body-weight regulation. Cell Metab 2006;3(2):141-6. (IF 13.7) Diano S, Farr SA, Benoit SC, McNay EC, da Silva I, Horvath B, Gaskin FS, Nonaka N, Jaeger LB, Banks WA, Morley JE, Pinto S, Sherwin RS, Xu L, Yamada KA, Sleeman MW, Tschöp M, Horvath TL. Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci 2006;9(3):381-8. (IF 15.5) Jürgens HS, Schürmann A, Kluge R, Ortmann S, Klaus S, Joost HG, Tschöp M. Hyperphagia, lower body temperature, and reduced running wheel activity precede the development of morbid obesity in New Zealand Obese mice. Physiol Genom 2006;25(2):234-41. (IF2.7) Perez-Tilve D, Stern JE, Tschöp M. The brain and the metabolic syndrome: not a wireless connection. Endocrinology 2006;147(3):1136-9. (IF 4.5) Seeley R & Tschöp M. How Diabetes went to our head. Nat Med 2006;12(1):47-9. (IF 22.5) Sanna B, Kaiser RA, Witt SA, Kimball TF, Tschöp M, Benoit SC, Molkentin JD. Modulatory Calcineurin-Interacting Proteins 1 and 2 Function as Physiologic Activators of Calcineurin in vivo. Proc Natl Acad Sci U S A 2006;103(19):7327-32. (IF 9.7) Theander-Carrillo C, Wiedmer P, Cettour-Rose P, Szanto I, Tschöp M, Rohner-Jeanrenaud F. Ghrelin action in the brain reveals CNS control of adipocyte metabolism. J Clin Invest 2006;116(7):1983-93. (IF 13.1) Abizaid A, Liu ZW, Andrews ZB, Elsworth J, Roth RH, Sleeman M, Mineur YS, Gao XB, Picciotto MR, Tschöp M, Horvath TL. Ghrelin modulates the activity of midbrain reward circuitry: implications for feeding and drug abuse. J Clin Invest 2006;116(12):3229-39. (IF 13.1) Tschöp M, Castaneda TR, Woods SC. The brain is getting ready for dinner. Cell Metab 2006;4(4):257-8. (IF 13.7)


Tschöp M, Thomas G. Fat fuels insulin resistance through Toll-like receptors. Nat Med 2006;12(12):1359-61. (IF 22.5) Pfluger P, Kampe J, Castañeda TR, Vahl T, D’Alessio D, Kruthaupt T, Benoit SC, Cuntz U, Rochlitz HJ, Moehlig M, Pfeiffer AFH, Koebnitz C, Wagner X, Otto B, Spranger J, Tschöp M. Effect of human body weight changes on circulating levels of peptide YY. J Clin Endocrinol Metab 2007;92(2):583-8. (IF 6.2) Nogueiras R Pfluger P, Tovar S, Myrtha A, Mitchell S, Perez-Tilve D, Vázquez MJ, Wiedmer P, Castañeda TR, DiMarchi R, Tschöp M, Schurmann A, Joost HG, Williams LM, Langhans W, Dieguez C. Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology 2007;148(1):21-6. (IF 4.5) Tschöp M, Hui DY, Horvath TL. Diet induced obesity and leptin resistance: The heart of the matter. Endocrinology 2007;148(3):921-3. (IF 4.5) Jürgens H, Schmolz K, Neschen S, Ortmann S, Blüher M, Klaus S, Tschöp M, Joost HG, Schürmann A. Development of diabetes in obese mice requiresdietary carbohydrates: Evidence for an essential role of glucose toxicity in β-cell destruction. Diabetologia 2007;50(7):1481-9. (IF 6.8) Inge T, Rose S, Burget L, Pfluger P, Tschöp M. Gastric Bypass for Hypothalamic Obesity in a Teenager: A case report. Nat Rev Endocrinol 2007;3(8):606-9. (IF 10) Sakkou M, Wiedmer P, Anlag K, Hamm A, Seuntjens E, Ettwiller L, Tschöp M, Treier M. A role for brain-specific homeobox factor Bsx in the control of hyperphagia and locomotory behavior. Cell Metab 2007;5(6):450-63. (IF 13.1) Wortley K, Anderson KD, Murphy A, Herman JP, Tschöp M, Yancopoulos GD, SJ, Sleeman MW. Peptide YY controls bone metabolism. Gastroenterology 2007;133(5):1534-43. (IF 11.7) Nomiyama T, Perez-Tilve D, Ogawa D, Gizard F, Zhao Y, Heywood EB, Jones KL, Tschöp M, Bruemmer D. Osteopontin links Obesity with Adipose Tissue Macrophage Infiltration and Insulin Resistance. J Clin Invest 2007;117(10):2877-88. (IF 13.1) Nogueiras R, Perez-Tilve D, Wiedmer P, Pfluger P, Castaneda S, Neschen S, Benoit SC, Hofmann SM, Hammond C, Schurmann S, Joost HG, Hui DY, Woods S, Rahmouni K, Butler AA, Farooqi S, O’Rahilly S, Rohner-Jeanrenaud F, Tschöp M. The central nervous melanocortin system directly controls triglyceride metabolism. J Clin Invest 2007;117(11):3475-88. (IF 13.1) Wiedmer P, Nogueiras R, D’Alessio D, Broglio F, Tschöp M. Ghrelin, Obesity and Diabetes. Nat Rev Endocrinol 2007;3(10):705-12. (IF 10) Tschöp M, Ravussin E. Peptide YY: Obesity’s cause and cure? Am J Physiol Endocrinol Metab 2007;293(5):E1131-3. (IF 4.75) Joost HG, Tschöp M. NO to obesity: Does nitric oxide link fat oxidation with insulin resistance? Endocrinology 2007;148(10):4545-7. (IF 4.5) Pfluger PT, Kirchner H, Gunnel S, Schrott B, Perez-Tilve D, Fu S, Benoit SC, Horvath T, Joost HG, Wortley KE, Sleeman MW, Tschöp M. Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure. Am J Physiol Gastrointest Physiol 2008;294(3):G610-8. (IF 3.43)


Hofmann SM, Chou L, Perez-Tilve D, Basford J, Grant E, Pfluger P, Hertz J, Tschöp M, Hui DY. Fat tissue specific ablation of low-density lipoprotein receptor-1 (LRP-1) decreases adiposity. J Clin Invest 2007;117(11):3271-82. (IF 13.1) Hofmann SM, Perez-Tilve D, Greer T, Coburn B, Basford J, Tschöp M, Hui DY. Defective lipid delivery modulates insulin responsiveness and metabolic responses to diet in apoE-deficient mice. Diabetes 2008;57(1):5-12. (IF 8.3) Nogueiras R, Lopez M, Sakkou M, Gao Q, Perez-Tilve D, Pfluger P, Wiedmer P, Horvath T, Treier M, Dieguez C, Tschöp M. Expression of Homeobox Factor Bsx, a Novel Molecular Link Between Hypothalamic Controls of Feeding and Spontaneous Physical Activity, is Regulated by Energy Availability. Endocrinology 2008;149(6):3009-15. (IF 4.5) Reed JA, Benoit SC, Pfluger P, Tschöp M, D’Alessio D, Seeley RJ. Mice with chronically increased circulating ghrelin develop age-related glucose intolerance. Am J Physiol Endocrinol Metab 2008;294(4):E752-60. (IF 4.75) López M, Saha AK, Lage R, Pérez-Tilve D, Vázquez MJ, Varela L, Tovar S, Rodríguez-Cuenca S, Deoliveir RM, Sangiao-Alvarellos S, Castañeda TR, Datta R, Dong JC, Culler M, Sleeman MW, Gallego R, Lelliott CJ, Tschöp M, Diéguez C, Vidal-Puig A. Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab 2008;7(5):389-399. (IF 13.1) Strassburg S, Anker SD, Castaneda TR, Burget L, Perez-Tilve D, Pfluger PT, Nogueiras R, Halem H, Dong JZ, Culler MD, Datta R, Tschöp M. Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats. Am J Physiol Endocrinol Metab 2008;295(1):E78-84. (IF 4.75) Tong J, Pfluger PT, Tschöp M. Gastric O-acyl transferase activates hunger signal to the brain. Proc Natl Acad Sci U S A 2008;105(17):6213-4. (IF 9) Isken F, Pfeiffer AF, Nogueiras R, Osterhoff MA, Ristow M, Thorens B, Tschöp M, Weickert MO. Deficiency of glucose-dependent insulinotropic polypeptide receptor prevents ovariectomy-induced obesity in mice. Am J Physiol Endocrinol Metab 2008;295(2):E350-5. (IF 4.75) Caton SJ, Yinglong B, Burget L, Spangler LJ, Tschöp M, Bidlingmaier M. Low- carbohydrate high-fat diets: effects on body composition, GH-IGF-I axis and body weight regain in rats. Obesity 2009;17(2):283-9. (IF 4.3) Tschöp M. There will be fat. Nat Med 2008;14(8):807. (IF 22.5) Perez-Tilve D, D'Alessio DA, Tschöp M. A sweet spot for the bariatric surgeon. Cell Metab 2008;8(3):177-9. (IF 13.7) Nogueiras R, Veyrat-Durebex C, Suchanek PM, Klein M, Tschöp J, Caldwell C, Woods SC, Wittmann G, Watanabe M, Liposits Z, Fekete C, Reizes O, Rohner- Jeanrenaud F, Tschöp M. Peripheral, but not central, CB1 antagonism provides food intake independent metabolic benefits in diet-induced obese rats. Diabetes 2008;57(11):2977-91. (IF 8.3) Andrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, Friedman JM, Tschöp M, Shanabrough M, Cline G, Shulman GI, Coppola A, Gao XB, Horvath TL, Diano S. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature 2008;454(7206):846-51. (IF 36) Pfluger PT, Herranz D, Velasco-Miguel S, Serrano M, Tschöp M. Sirt1 protects against


high-fat diet-induced metabolic damage. Proc Natl Acad Sci U S A 2008;105(28):9793-8. (IF 9) Sutton G, Perez-Tilve D, Nogueiras R, Fang J, Kim J, Cone R, Gimble J, Tschöp M, Butler AA. The melanocortin-3 receptor is required for entrainment to meal intake. J Neurosci 2008;28(48):12946-55. (IF 7.1) Lockie SH, Muller T, Tschöp M. Coupled with Uncouplers: The Curious Case of Lifespan. Am J Physiol Endocrinol Metab 2009; 296(4):E621-7. (IF 4.75) Nogueiras R, Pérez-Tilve D, Veyrat-Durebex C, Morgan DA, Varela L, Haynes WG, Patterson JT, Disse E, Pfluger PT, López M, Woods SC, DiMarchi R, Diéguez C, Rahmouni K, Rohner-Jeanrenaud F, Tschöp M. Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet induced obesity. J Neurosci 2009;29(18):5916-25. (IF 7.1) Hugenholtz P, Karp C, Tschöp M. Florid obesity: a dip into the gene pool of the microbiome. Nat Biotechnol 2009;27(4):344-6. (IF 23.3) Hofmann SM & Tschöp M. Dietary Sugars: A fat difference. J Clin Invest 2009;119(5):1089-92. (IF 13.1) Tschöp J, Kasten K, Guanciale K, Nogueiras R, Tschöp M, Caldwell C. The cannabinoid receptor 2 is critical for the host response to sepsis. J Immunol 2009;183(1):499-505. (IF 5.8) Kampe J, Tschöp M, Hollis JH, Oldfield BJ. An anatomic basis for the communication of hypothalamic, cortical and mesolimbic circuitry in the regulation of energy balance. Eur J Neurosci 2009;30(3):415-30. (IF 3.6) Isken F, Weickert MO, Tschöp M, Nogueiras R, Abdelrahman A, Klaus S, Thorens B, Pfeiffer A. Metabolic effects of diets differing in glycaemic index are influenced by age and GIP receptor deficiency. Diabetologia 2009;52(10):2159-68. (IF 6.8) Kirchner H., Gutierrez J, Pfluger PT, Morgan TA, Solenberg P, Willency J, Schuermann A, Joost HG, Jandacek R, Hale J, Heiman ML, Tschöp M. GOAT links dietary lipids with the endocrine control of energy balance. Nat Med 2009;15(7):741-5. (IF 22.5) Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R and Tschöp M. A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nat Chem Biol 2009;5(10):749-57. (IF 14.7) Costanzo D., Pfluger PT, Dougherty M, Stock JL, Boehm M, Chaika O, Fernandez M, Fisher K, Kortum RL, Hong EG, Schreiner A, Volle DJ, Treece T, Smift AL, Winer M, Chen D, Wu M, Shaw AS, McNeish J, Kim JK, Morrision DK, Tschöp M, Lewis RE. The Molecular Scaffold KSR2 Regulates AMPK Signaling to Control Energy, Lipid and Glucose Metabolism. Cell Metab 2009;10(5):366-78. (IF 13.7) Andrews Z, Diano S, Gao Z, Shanabrough M, Tschöp M, DiMarchi R, Elmquist J, Horvath T. Ghrelin promotes nigrostriatal dopamine function and protects it in a redox-dependent manner. J Neurosci 2009;29(45):14057-65. (IF 7.1) Sutton GM, Begriche K, Kumar KG, Gimble JM, Perez-Tilve D, Nogueiras R, McMillan RP, Hulver MW, Tschöp M, Butler AA. Central nervous system melanocortin-3 receptors are


required for synchronizing metabolism during entrainment to restricted feeding during the light cycle. FASEB J 2010;24(3):862-72. (IF 5.7) Czyzyk TA, Nogueiras R, Lockwood J, McKinzi JH, Pintar JE, Hammond C, Tschöp M, Statnick MA. Resistance to diet-induced obesity and increased energy expenditure following genetic ablation of kappa opioid receptors in mice. FASEB J 2010;24(4):1151-9. (IF 5.7) Lee SJ, Pfluger PT, Kim JY, Nogueiras R, Tschöp M, Diaz-Meco MT, Moscat J. A functional role for the p62 – Erk1 axis in the control of energy homeostasis and adipocyte proliferation. EMBO Reports 2010;11(3):226-32. (IF 9.21) Castañeda TR, Tong J, Datta R, Culler M, Tschöp M. Ghrelin in the regulation of body weight and metabolism. Front Neuroendocrinol 2010;31(1):44-60. (IF 11.43) Wood MA, Pérez-Tilve D, Chambers A, Wilson-Pérez HE, Sandoval DA, Berger J, Toure M, Tschöp M, Woods SC, Seeley RJ. Sleeve gastrectomy in rats temporarily affects food intake, but chronically improves metabolic substrate choice and adiposity. Gastroenterology 2010;138(7):2426-36. (IF 11.7) Tong J, Aulinger BA, Davis H, Yang Q, Gaylinn BD, Thorner MO, Tschöp M, D’Alessio DD, Tso P. The Intestinal Lymph Fistula Model. Am J Physiol Gastrointest Physiol 2010;298(3):G474-80. (IF 3.43) Kirchner H, Tong J, Tschöp M, Pfluger PT. Ghrelin and PYY in the regulation of Energy Balance and Metabolism: Lessons from Mouse Mutants. Am J Physiol Endocrinol Metab 2010;298(5):E909-19. (IF 4.75) Perez-Tilve D, González-Matías LC, Aulinger BA, Alvarez-Crespo M, Gil-Lozano M, Alvarez E, Andrade MA, Tschöp M, D'Alessio D, Mallo F. Exendin-4 acutely increases blood glucose in rats via the autonomic nervous system. Am J Physiol Endocrinol Metab 2010;298(5):E1088-9. (IF 4.75) Labonté ED, Pfluger PT, Kuhel DG, Rojas JC, Magness DP, Jandacek RC, Tschöp M, Hui DY. Postprandial Lysophospholipid Suppresses Hepatic Fatty Acid Oxidation: The Molecular Link between Group 1B Phospholipase A2 and Diet-induced Obesity. FASEB J 2010;24(7):2516-24. (IF 5.7) Strasburg S, Pfluger PT, Chaudhary N, Tso P, Tschöp M, Anker SD, Nogueiras R, Perez Tilve D. Action profile of the anti-obesity drug candidate oleoyl estrone in rats. Obesity 2010;18(12):2260-7. (IF 4.3) Tschöp J, Nogueiras R, Lockie S, Kasten K, Castañeda TR, Huber N, Guanciale K, Perez-Tilve D, Woods SC, Oldfield B, Clarke I, Chua S. Jr, Farooqi IS, O’Rahilly S, Caldwell CC, Tschöp M. CNS leptin action modulates immune response and survival in sepsis. J Neurosci 2010;30(17):6036-47. (IF 7.1) Lee SJ, Young J, Nogueiras R, Linares J, Perez-Tilve D, Drew A, Leitges M, Tschöp M, Diaz-Meco MT, Moscat J. PKCz controls hematopoiesis independent inflammation critical for obesity-induced glucose intolerance. Cell Metab 2010;12(1):65-77. (IF 13.7) Perez-Tilve D, Hofmann S, Basford J, Pfluger PT, Patterson PT, Grant E, Perez-Wilson H, Granholm N, Arnold M, Trevaskis JL, Butler AA, Davidson WS, Woods SC, Benoit SC, Sleeman MW, DiMarchi RD, Hui DY, Tschöp M. The CNS melanocortin system directly controls circulating cholesterol. Nat Neurosci 2010;13(7):877-82. (IF 15.5) Tong J, Prigeon RL, Davis HW, Bidlingmaier M, Kahn SE, Cummings DE, Tschöp MH, D'Alessio D. Ghrelin Suppresses Glucose-stimulated Insulin Secretion and Deteriorates


Glucose Tolerance in Healthy Humans. Diabetes 2010;59(9):2145-51. (IF 8.3) Horvath TL, Perez-Tilve D, Pfluger PT, Broennecke HS, Levin B, Cowley MA, Diano S, Tschöp M. Synaptic Input Organization of the Melanocortin System Predicts Diet-Induced Hypothalamic Reactive Gliosis and Obesity. Proc Natl Acad Sci U S A 2010;107(33):14875-80. (IF 9.7) Patterson JT, Gelfanov VM, Ottaway N, Holland J, JHembree J, Perez-Tilve D, Pfluger PT, Smiley DL, Tschöp M, DiMarchi R. A Humanized GLP-1 Receptor Antagonist. ACS Chem Biol 2011;6(2):135-145. (IF 6) Habegger K, Pfluger P, Perez-Tilve D, Geary N, Bartness T, DiMarchi R & Tschöp M. Glucagon agonism as a therapeutic strategy in metabolic disease. Nature Rev Endocrinol 2010;6(12):689-97. (IF 10) Shin YK, Martin B, Kim W, White CM, Ji S, Tschöp M, Sun Y, Smith RG, Sévigny J, Maudsley S, Egan JM. Ghrelin is produced in taste cells and ghrelin receptor null mice show reduced taste responsivity to salty (NaCl) and sour (citric acid) tastants. PLOS One 2010;5(9):e12729. (IF 4.1) Müller TD, Tschöp M, Jarick I, Ehrlich SS, Scherag S, Herpertz-Dahlmann BB, Zipfel S, Herzog WW, de Zwaan M, Burghardt R, Fleischhaker C, Klampf K, Wewetzer C, Herpertz S, Zeeckl A, Tagay S, Burgmer M, Pfluger PT, Scherag AA, Hebebrand J, Hinney A. Genetic Variation Of The Ghrelin Activator Gene Ghrelinoacyltransferase (GOAT) Is Associated With Anorexia Nervosa. J Psych Res 2010;45(5): 706-11. (IF 4.7) Bielohuby M, Menhofer D, Kirchner K, Stoehr BJM, Müller TD, Stock P, Hempel M, Stemmer K, Pfluger PT, Kienzle E, Christ B, Tschöp M, Bidlingmaier M. Induction of ketosis in rats fed low-carbohydrate, high fat diets depends on the relative abundance of dietary fat and protein.Am J Physiol Endocrinol Metab 2011;300(1):E65-76. (IF 4.75) Barnett BP, Hwang Y, Taylor M, Kirchner H, Pfluger PT, Bernard V, Lin Y, Erin M. Bowers EM, Mukherjee C, Song WJ, Longo PA, Leahy DJ, Hussain MA, Tschöp M, Boeke JD, Cole PA. Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor. Science 2010;330(6011):1689-92. (IF 31) Castañeda TR, Nogueiras R, Müller TD, R. Krishna R, Grant E, Jones A, N. Ottaway, Anantakrishna G, Pfluger PT, Chaudhary N, Solomon MB, Woods SC, Herman JP, Tschöp M. Decreased glucose tolerance and plasma adiponectin/resistin ratio in a mouse model of post-traumatic stress disorder (PTSD). Diabetologia 2010; 54(4):900-9. (IF 6.8) Barnett BP, Hwang Y, Taylor MS, Kirchner H, Pfluger PT, Bernard V, Lin YY, Bowers EM, Mukherjee C, Song WJ, Longo PA, Leahy DJ, Hussain MA, Tschöp MH, Boeke JD, Cole PA. Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science. 2010 Dec 17;330(6011):1689-92. doi: 10.1126/science.1196154. (IF 31.36) Yi CX, Kalsbeek A, Tschöp M. Autonomic MC sets the metabolic tone. Cell Metab 2011;13(2):121-3. (IF 13.7) Tong J, Mannea E, Aime P, Pfluger P, Castaneda T, de Araujo I, Ren X, Davis H, Lee J, Benoit S, Pixley S, Heiman M, Julliard K, Horvath TL, Sleeman MM, D’Alessio DD, Obici S, Frank R, Tschöp M. Ghrelin Enhances Exploratory Sniffing in Rodents and Humans. J Neurosci 2011;31(15):5841-5846. (IF 7.1) Perez-Tilve D, Heppner K, Kirchner H, Lockie-Haas S, Smiley D, Woods SC, Tschöp M, Pfluger P. Ghrelin induced adiposity is independent of orexigenic effects. FASEB J 2011;25(8): 2814-22. (IF 5.7)


Rudovich NN, Nikiforova VJ, Otto B, Pivovarova O, Gögebakan O, Erban A, Möhlig M, Weickert MO, Spranger J, Tschöp MH, Willmitzer L, Nauck MA, Pfeiffer AF. Metabolomic linkage unveils functional interaction between Glucose-dependent Insulinotropic Peptide (GIP) and Ghrelin in Humans. Am J Physiol Endocrinol Metab 2011;301(4):E608-17. (IF 4.75) Krawczewski Carhuatanta KA, Demuro G, Tschöp MH, Pfluger PT, Benoit SC, Obici S. Voluntary Exercise Improves High-Fat Diet-Induced Leptin Resistance Independent of Adiposity. Endocrinology 2011;152(7):2655-64. (IF 4.5)

Lockie SH, Czyzyk TA, Chaudhary N, Perez-Tilve D, Woods SC, Oldfield BJ, Statnick MA, Tschöp MH. CNS opioid signaling separates cannabinoid receptor 1-mediated effects on body weight and mood-related behavior in mice. Endocrinology 2011 Oct;152(10):3661-7. doi: 10.1210/en.2011-1220. Epub 2011 Aug 2. (IF 4.46)

Hillman JB, Tong J, Tschöp MH. Ghrelin biology and its role in weight-related disorders. Discov Med 2011 Jun;11(61):521-8. Review. PMID: 21712018 [PubMed - indexed for MEDLINE] (IF N/A)

Pfluger PT, Castañeda TR, Heppner KM, Strassburg S, Kruthaupt T, Chaudhary N, Halem H, Culler MD, Datta R, Burget L, Tschöp MH, Nogueiras R, Perez-Tilve D. Ghrelin, peptide YY and their hypothalamic targets differentially regulate spontaneous physical activity. Physiol Behav 2011;105(1): 52-61. (IF 2.9) Yi CX, Tschöp M. CNS control of systemic metabolism in health and disease. Nat Med invited mini review, online only (IF 22.5) Yi CX, Scherer T, Tschöp M. Cajal Revisited: Is the VMH Making Us Fat? Nat Neurosci 2011;14(7):806-8. (IF 15.5) Perez-Tilve D, Davidson WS, Tschöp M, Hofmann SM. CNS regulation of plasma cholesterol. Ann Med Epub 2011 Jul 4. (IF 3.5) Perez-Tilve D, Habbeger KM, Tschöp MH, Hofmann SM. Neural regulation of cholesterol metabolism. Curr Opin Lipidol 2011;22(4):283-7. (IF 6.1) Tschöp M, Speakman J, Almind K, Auwerx J, Brüning JC, Chambon J, Chan L, Eckel R, Farese RV jr., Galgani J, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Mueller T, Muenzberg H, Neel B, Pfluger PT, Plum L, Reitman M, Rahmouni K, Saha P, Shulman G, Thomas G, Zhang B, Kahn CR, Ravussin E. A Guide to Analysis of Mouse Energy Metabolism. Nat Methods 2011;9(1):57-63. (IF 19.3) Haas-Lockie S, Czyzyk TA, Chaudhary N, Perez-Tilve D, Woods SC, Oldfield BJ, Statnick MA, Tschöp M. CNS opioid signalling separates CB1 mediated effects on body weight and mood. Endocrinology 2011;152(10):3661-7. (IF 4.5) Seeley RJ & Tschöp M. Uroguanylin: how the gut got another satiety hormone. J Clin Invest 2011;121(9):3384-6. (IF 13.1) Bajzer M, Olivieri M, Haas MK, Pfluger PT, Magrisso IJ, Foster MT, Tschöp MH, Krawczewski-Carhuatanta KA, Cota D, Obici S. Cannabinoid receptor 1 (CB1) antagonism enhances glucose utilisation and activates brown adipose tissue in diet-induced obese mice. Diabetologia 2011;54(12):3121-31. (IF 6.8) Rediger A, Piechowski CL, Yi CX, Tarnow P, Schöneberg T, Strotmann R, Grüters A,


Tschöp MH, Krude H, Kleinau G, Biebermann H. Mutually opposite signaling modulation by heterodimerization of ghrelin- and melanocortin-3 receptors. J Biol Chem J Biol Chem. 2011;286(45):39623-31. (IF 4.8)

Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, Zhao X, Sarruf DA, Izgur V, Maravilla KR, Nguyen HT, Fischer JD, Matsen ME, Wisse BE, Morton GJ, Horvath TL, Baskin DG, Tschöp MH, Schwartz MW. Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest. 2012 Jan 3;122(1):153-62. doi: 10.1172/JCI59660. Epub 2011 Dec 27. Erratum in: J Clin Invest 2012 Feb 1;122(2):778. PMID:22201683 [PubMed - indexed for MEDLINE] Free PMC Article PUBMED (IF 12.812)

Yi CX, Heppner KM, Kirchner H, Tong J, Bielohuby M, Gaylinn BD, Müller TD, Bartley E, Davis HW, Zhao Y, Joseph A, Kruthaupt T, Ottaway N, Kabra D, Habegger KM, Benoit SC, Bidlingmaier M, Thorner MO, Perez-Tilve D, Tschöp MH, Pfluger PT. The GOAT-Ghrelin System Is Not Essential for Hypoglycemia Prevention during Prolonged Calorie Restriction. PLoS One 2012;7(2):e32100. (IF 4.1)

Al Massadi O, Tschöp MH, Tong J. Ghrelin acylation and metabolic control. Peptides 2011 Nov;32(11):2301-8. doi: 10.1016/j.peptides.2011.08.020. Epub 2011 Aug 27. Review. PMID: 21893140 [PubMed - indexed for MEDLINE] (IF 2.434)

Castañeda TR, Abplanalp W, Um SH, Pfluger PT, Schrott B, Brown K, Grant E, Carnevalli L, Benoit SC, Morgan DA, Gilham D, Hui DY, Rahmouni K, Thomas G, Kozma SC, Clegg DJ, Tschöp MH. Metabolic control by s6 kinases depends on dietary lipids. PLoS One 2012;7(3):e32631. (IF 4.1) Betz MJ, Bielohuby M, Mauracher B, Abplanalp W, Müller HH, Pieper K, Ramisch J, Tschöp MH, Beuschlein F, Bidlingmaier M, Slawik M. Isoenergetic feeding of low carbohydrate-high fat diets does not increase brown adipose tissue thermogenic capacity in rats. PLoS One 2012;7(6):e38997. (IF 4.1) Bielohuby M, Stemmer K, Berger J, Ramisch J, Smith K, Holland J, Parks K, Pfluger PT, Habegger KM, Tschöp MH, Seeley RJ, Bidlingmaier M. Carbohydrate content of post-operative diet influences the effect of vertical sleeve gastrectomy on body weight reduction in obese rats. Obes Surg 2012;22(1):140-51. (IF 3.3) Rediger A, Piechowski CL, Habegger K, Grüters A, Krude H, Tschöp MH, Kleinau G, Biebermann H. MC4R Dimerization in the Paraventricular Nucleus and GHSR/MC3R Heterodimerization in the Arcuate Nucleus: Is There Relevance for Body Weight Regulation. Neuroendocrinology 2012;95(4):277-288. (IF 2.4) Heppner KM, Müller TD, Tong J, Tschöp MH. Ghrelin in the control of energy, lipid, and glucose metabolism. Methods Enzymol 2012;514:249-260. (IF 1.6) KIrchner H, Heppner KM, Tschöp MH. The role of ghrelin in the control of energy balance. Handb Exp Pharmacol 2012;(209):161-183. (IF N/A) Day JW, Gelfanov V, Smiley D, Carrington PE, Eiermann G, Chicchi G, Erlon MD, Gidda J, Thornberry NA, Tschöp MH, Marsh DJ, SinhaRoy R, DiMarchi R, Pocai A. Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents. Biopolymers 2012;98(5):443-450. (IF 2.879) Thaler JP, Yi CX, Guyenet S, Hwang B, Zhao X, Sarruf D, Nguyen HT, Fisher JD, Wisse BE, Morton G, Horvath T, Baskin D, Tschöp MH, Schwartz MW. High-Fat Diet Rapidly Induces Hypothalamic Neuronal Injury. J Clin Invest 2012;122(1):153-62. (IF 13.1)


Wiedmer P, Chaudhary N, Rath M, Yi CX, Ananthakrishnan G, Nogueiras R, Wirth EK, Kirchner H, Schweizer U, Jonas W, Veyrat-Durebex C, Rohner-Jeanrenaud F, Schürmann A, Joost HG, Tschöp MH, Perez-Tilve D. The HPA axis modulates the CNS melanocortin control of liver triacylglyceride metabolism. Physiol Behav 2012;105(3):791-9. (IF 2.9) Yi CX, Foppen E, Abplanalp W, Gao Y, Alkemade A, la Fleur SE, Serlie MJ, Fliers E, Buijs RM, Tschöp MH, Kalsbeek A. Glucocorticoid signaling in the arcuate nucleus modulates hepatic insulin sensitivity. Diabetes 2012;61(2):339-45. (IF 8.3) Myers MG Jr, Heymsfield SB, Haft C, Kahn BB, Laughlin M, Leibel RL, Tschöp MH, Yanovski JA. Challenges and opportunities of defining clinical leptin resistance. Cell Metab 2012;15(2):150-6. (IF 13.7) Heppner KM, Müller TD, Kirchner H, Perez-Tilve D, Pfluger PT, Tschöp MH, Hofmann SM. The role of ghrelin-octanoyl-acyl-transferase (GOAT) in thermoregulation. J Endocrinol Invest 2012 Epub Apr 23. (IF 1.6) Caton SJ, Bielohuby M, Bai Y, Spangler LJ, Burget L, Pfluger P, Reinel C, Czisch M, Reincke M, Obici S, Kienzle E, Tschöp MH, Bidlingmaier M. Low-carbohydrate high-fat diets in combination with daily exercise in rats: Effects on body weight regulation, body composition and exercise capacity. Physiol Behav 2012;106(2):185-92. (IF 2.9) Müller TD, Sullivan LM, Habegger K, Yi CX, Kabra D, Grant E, Ottaway N, Krishna R, Holland J, Hembree J, Perez-Tilve D, Pfluger PT, DeGuzman MJ, Siladi ME, Kraynov VS, Axelrod DW, DiMarchi R, Pinkstaff JK, Tschöp MH. Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21. J Pept Sci 2012 June;18(6);383-393. (IF 1.8) Tschöp MH, DiMarchi RD. Defeating Diabesity: The case for personalized combinatorial therapies. Diabetes 2012 Jun;61(6):1309-1314. (IF 8.3) Nogueiras R, Habegger KM, Chaudhary N, Finan B, Banks AS, Dietrich MO, Horvath TL, Sinclair DA, Pfluger PT, Tschöp MH. Sirtuin 1 and Sirtuin 3: Physiological modulators of metabolism. Physiol Rev 2012 Jul;92(3):1479-1514. (IF 26.9) Czyzyk TA, Tomero-Picó A, PIntar J, McKinzie JH, Tschöp MH, Statnick MA, Nogueiras R. Mice lacking δ-opioid receptors resist the development of diet-induced obesity. FASEB J 2012 Aug;26(8):3483-3492. (IF 5.7) Pfluger PT, Schriever SC, Tschöp MH. Nutropiods, hedonism in the gut? Cell Metab 2012 Aug 8;16(2):137-139. (IF 13.7) Tong J, D’Alessio D, Ramisch J, Davis HW, Stambrook E, Tschöp MH, Bidlingmaier M. Ghrelin stimulation of growth hormone isoforms: parallel secretion of total and 20-kDa growth hormone and relation to insulin sensitivity in healthy humans. J Clin Endocrinol Metab 2012 Sept;97(9):3366-3374. (IF 6.2) Davis JF, Perello M, Choi DL, Magrisso IJ, Kirchner H, Pfluger PT, Tschoep MH, Zigman JM, Benoit SC. GOAT induced ghrelin acylation regulates hedonic feeding. Horm Behav 2012 Nov;62(5):598-604. doi: 10.1016/j.yhbeh.2012.08.009. Epub 2012 Sep 8. PMID: 22982020 [PubMed - indexed for MEDLINE] (IF 3.735) Yi CX, Tschöp MH, Woods SC, Hofmann SM. High-fat-diet exposure induces IgG accumulation in hypothalamic microglia. Dis Model Mech 2012 Sep;5(5):686-690. (IF 4.9) Stemmer K, Perez-Tilve D, Ananthakrishnan G, Bort A, Seeley RJ, Tschöp MH, Dietrich


DR, Pfluger PT. High-fat-diet-induced obesity causes an inflammatory and tumor-promoting microenvironment in the rat kidney. Dis Model Mech 2012 Sep;5(50:627-635. (IF 4.9) Yi CX, Tschöp MH. Brain-gut-adipose-tissue communication pathways at a glance. Dis Model Mech 2012 Sep;5(5):583-587. (IF 4.9) Rodgers RJ, Tschöp MH, Wilding JP. Anti-obesity drugs: past, present and future. Dis Model Mech 2012 Sep;5(5):621-626. (IF 4.9) Davis JF, Schurdak JD, Magrisso IJ, Mul JD, Grayson BE, Pfluger PT, Tschöp MH, Seeley RJ, Benoit SC. Gastric bypass surgery attenuates ethanol consumption in ethanol-preferring rats. Biol Psychiatry 2012 Sept 1;72(5):354-360. (IF 8.28) Riepl RL, Fischer R, Hautmann H, Hartmann G, Müller TD, Tschöp M, Toepfer M, Otto B. Influence of acute exposure to high altitude on basal and postprandial plasma levels of gastroenteropancreatic peptides. PLoS One 2012;7(9):e44445. doi: 10.1371/journal.pone.0044445. Epub 2012 Sep 6. (IF 4.1) Zeltser L, Seeley R, Tschöp M. Synaptic plasticity and CNS control of metabolism. Nat Neurosci 2012 Oct;15(10):1336-1342. (IF 15.5) Habegger KM, Matzke D, Ottaway N, Hembree J, Holland J, Raver C, Mansfeld J, Müller TD, Perez-Tilve D, Pfluger PT, Lee SJ, Diaz-Meco M, Moscat J, Leitges M, Tschöp MH, Hofmann SM. Role of adipose and hepatic atypical protein kinase C lambda (PKCλ) in the development of obesity and glucose intolerance. Adipocyte 2012 Oct 1;1(4):203-214. (IF N/A) Heppner KM, Chaudhary N, Müller TD, Kirchner H, Habegger KM, Ottaway N, Smiley DL, Dimarchi R, Hofmann SM, Woods SC, Siversten B, Holst B, Pfluger PT, Perez-Tilve D, Tschöp MH. Acetylation type determines ghrelin’s effects on energy homeostasis in rodents. Endocrinology 2012 Oct;153(10):4687-4695. (IF 4.5) Kirchner H, Hofmann SM, Fischer-Rosinsky A, Hembree J, Abplanalp W, Ottaway N, Donelan E, Krishna R, Woods SC, Müller TD, Spranger J, Perez-Tilve D, Pfluger PT, Tschöp MH, Habegger KM. Calorie restriction chronically impairs metabolic programming in mice. Diabetes 2012 Nov;61(11):2734-2742. (IF 8.3) Lockie SH, Heppner KM, Chaudhary N, Chabenne JR, Morgan DA, Veyrat-Durebex C, Ananthakrishnan G, Rohner-Jeanreaud F, Drucker DJ, Dimarchi R, Rahmouni K, Oldfield BJ, Tschöp MH, Perez-Tilve D. Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like Peptide-1 receptor signaling. Diabetes 2012 Nov;61(11):2753-2762. (IF 8.3) Finan B, Yang B, Ottaway N, Stemmer K, Müller TD, Yi CX, Habegger KM, Schriever SC, Garcia-Caceres C, Kabra DG, Hembree J, Holland J, Raver C, Seeley RJ, Hans W, Irmler M, Beckers J, Hrabe de Angelis M, Tiano JP, Mauvais-Jarvis F, Perez-Tilve D, Pfluger PT, Zhang L, Gelfanov V, DiMarchi RD, Tschöp MH. Targeted estrogen delivery reverses the metabolic syndrome. Nat Med 2012 Nov 11 doi:10.1038/nm.3009. (IF 22.5) Yi, C-X, Gericke M, Krüger M, Alkemade A, Kabra DG, Hanske S, Filosa J, Pfluger P, Bingham N, Woods SC, Herman J, Kalsbeek A, Bauman M, Lang R, Stern JE, Bechmann I, Tschöp MH. High calorie diet triggers hypothalamic angiopathy. Mol Metab 2012 doi:10.1016/j.molmet.2012.08.004. (IF N/A) Müller TD, Tschöp MH, Hofmann SM. Emerging Function of Fat mass and Obesity-associated protein (FTO). PloS Genet 2013 Jan;9(1):e1003223. (IF 9.54)


Chambers AP, Kirchner H, Wilson-Perez HE, Willency JA, Hale JE, Gaylinn BD, Thorner MO, Pfluger PT, Gutierrez JA, Tschöp MH, Sandoval DA, Seeley RJ. The Effects of Vertical Sleeve Gastrectomy in Rodents Are Ghrelin Independent. Gastroenterology 2012 Sept 17 doi:10.1053/j.gastro.2012.09.009. (IF 11.7) Habegger KM, Matzke D, Ottaway N, Hembree J, Holland J, Raver C, Mansfeld J, Müller TD, Perez-Tilve D, Pfluger PT, Lee SJ, Diaz-Meco M, Moscat J, Leitges M, Tschöp MH, Hofmann SM. Role of adipose and hepatic atypical protein kinase C lambda (PKCλ) in the development of obesity and glucose intolerance. Adipocyte 2012 Oct 1;1(4):203-214. PMID:23700535 [PubMed] Free PMC Article (IF N/A) García-Cáceres C, Yi CX, Tschöp MH. Hypothalamic astrocytes in obesity. Endocrinol Metab Clin North Am. 2013 Mar;42(1):57-66. doi: 10.1016/j.ecl.2012.11.003. Epub 2012 Dec 12. PMID:23391239 [PubMed - in process] (IF 3.563) Müller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger KM, Hembree J, Heppner K, Hofmann S, Holland J, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch AK, Schriever SC, Speakman J, Tseng Y-H, Diaz-Meco M, Pfluger PT, Moscat J, Tschöp MH. p62 links beta-adrenergic input with mitochondrial function. J Clin Invest 2013 Jan 2;123(1):469-478. (IF 13.1)

Habegger KM, Stemmer K, Cheng C, Müller TD, Heppner KM, Ottaway N, Holland J, Hembree JL, Smiley D, Gelfanov V, Krsihna R, Arafat AM, Konkar A, Belli S, Kapps M, Woods SC, Hofmann SM, D’Alessio D, Pfluger PT, Perez-Tilve D, Seeley RJ, Konishi M, Itoh N, Kharitonekov A, Spranger J, DiMarchi RD, Tschöp MH. Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions Diabetes 2013 Jan 10 doi:10.2337/db12-1116. (IF 8.3)

Müller A, Kleinau G, Piechowski CL, Müller TD, Finan B, Pratzka J, Grüters A, Krude H, Tschöp MH, Biebermann H. G-protein coupled receptor 83 (GPR83) signaling determined by constitutive and zinc(II)-induced activity. PLoS One PLoS One 2013;8(1):e53347. doi: 10.1371/journal.pone.0053347. Epub 2013 Jan 15. (IF 4.1) Lim CT, Kola B, Feltrin D, Perez-Tilve D, Tschöp MH, Grossman AB, Korbonits M. Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism. Mol Cell Endocrinol Jan 30;365(2):303-308. (IF 4.2) García-Cáceres C, Yi CS, Tschöp MH. Hypothalamic astrocytes in obesity. Endocrinol Metab Clin North Am 2013 Mar;42(1):57-66. (IF 3.4) Tong J, Prigeon RL, Davis HW, Bidlingmaier M, Tschöp MH, D'Alessio D. Physiologic concentrations of exogenously infused ghrelin reduces insulin secretion without affecting insulin sensitivity in healthy humans J Clin Endocrinol Metab 2013 Jun;98(6):2536-43. doi: 10.1210/jc.2012-4162. Epub 2013 Apr 15. (IF 6.2) Kirchner H, Heppner KM, Holland J, Kabra D, Tschöp MH, Pfluger PT. Ablation of Ghrelin O-Acyltransferase Does Not Improve Glucose Intolerance or Body Adiposity in Mice on a Leptin-Deficient ob/ob Background. PLoS One 2013 Apr 22;8(4):e61822. doi: 10.1371/journal.pone.0061822. Print 2013. (IF 4.1) Müller TD, Tschöp MH. Ghrelin - a key pleiotropic hormone-regulating systemic energy metabolism. Endocr Dev 2013;25:91-100. doi: 10.1159/000346590. Epub 2013 Apr 25. (IF N/A) Tong J, Dave N, Mugundu GM, Davis HW, Gaylinn BD, Thorner MO, Tschöp MH, D'Alessio


D, Desai PB. The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects. Eur J Endocrinol 2013 May 2;168(6):821-8. doi: 10.1530/EJE-13-0072. Print 2013. (IF 3.575) Harley IT, Giles DA, Pfluger PT, Burgess SL, Walters S, Hembree J, Raver C, Rewerts CL, Downey J, Flick LM, Stankiewicz TE, McAlees JW, Wills-Karp M, Balfour Sartor R, Divanovic S, Tschöp MH, Karp CL. Differential colonization with segmented filamentous bacteria and Lactobacillus murinus do not drive divergent development of diet-induced obesity in C57BL/6 mice. Mol Metab. 2013 May 10;2(3):171-83. doi: 10.1016/j.molmet.2013.04.004. eCollection 2013. PMID: 24049732 [PubMed] PMCID: PMC3773832 Free PMC Article. (IF N/A) Müller TD, Müller A, Yi CX, M Habegger K, Meyer CW, Gaylinn BD, Finan B, Heppner K, Trivedi C, Bielohuby M, Abplanalp W, Meyer F, Piechowski CL, Pratzka J, Stemmer K, Holland J, Hembree J, Bhardwaj N, Raver C, Ottaway N, Krishna R, Sah R, Sallee FR, Woods SC, Perez-Tilve D, Bidlingmaier M, Thorner MO, Krude H, Smiley D, Dimarchi R, Hofmann S, Pfluger PT, Kleinau G, Biebermann H, Tschöp MH. The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. Nat Commun 2013 Jun 7;4:1968. doi: 10.1038/ncomms2968. (IF 10.015) Stemmer K, Bielohuby M, Grayson BE, Begg DP, Chambers AP, Neff C, Woods SC, Erbe RG, Tschöp MH, Bidlingmaier M, Clemens TL, Seeley RJ. Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rates. Endocrinology Endocrinology 2013 Jun;154(6):2015-24. doi: 10.1210/en.2012-2130. Epub 2013 Apr 3. (IF 4.5) Oelkrug R, Goetze N, Exner C, Lee Y, Ganjam GK, Kutschke M, Müller S, Stöhr S, Tschöp MH, Crichton PG, Heldmaier G, Jastroch M, Meyer CW. Brown fat in a protoendothermic mammal fuels eutherian evolution. Nat Commun. 2013;4:2140. doi: 10.1038/ncomms3140. PMID: 23860571 [PubMed - in process] Free PMC Article. (IF 10.015) Bielohuby M, Sisley S, Sandoval D, Herbach N, Zengin A, Fischereder M, Menhofer D, Stoehr BJ, Stemmer K, Wanke R, Tschöp MH, Seeley RJ, Bidlingmaier M. Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets. Am J Physiol Endocrinol Metab 2013 Nov;305(9):E1059-70. doi:10.1152/ajpendo.00208.2013. Epub 2013 Aug 27. (IF 4.51) Stevanovic D, Trajkovic V, Müller-Lühlhoff S, Brandt E, Abplanalp W, Bumke-Vogt C, Liehl B, Wiedmer P, Janjetovic K, Starcevic V, Pfeiffer AF, Al-Hasani H, Tschöp MH, Castañeda TR. Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling. Mol Cell Endocrinol 2013 Dec 5;381(1-2):280-90. doi: 10.1016/j.mce.2013.08.009. Epub 2013 Aug 29. (IF 3.82) Heppner KM, Piechowski CL, Müller A, Ottaway N, Sisley S, Smiley DL, Habegger KM, Pfluger PT, Dimarchi R, Biebermann H, Tschöp MH, Sandoval DA, Perez-Tilve D. Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via CNS ghrelin receptors. Diabetes 2013 Sep 23. [Epub ahead of print] (IF 8.3) Habegger KM, Kirchner H, Yi CX, Heppner KM, Sweeney D, Ottaway N, Holland J, Amburgy S, Raver C, Krishna R, Müller TD, Perez-Tilve D, Pfluger PT, Obici S, Dimarchi RD, D'Alessio DA, Seeley RJ, Tschöp MH. GLP-1R Agonism Enhances Adjustable Gastric Banding In Diet-Induced Obese Rats. Diabetes 2013 Sep;62(9):3261-7. doi: 10.2337/db13-0117. Epub 2013 Jun 17. (IF 8.3) Habegger KM, Al-Massadi O, Heppner KM, Myronovych A, Holland J, Berger J, Yi CX, Gao Y, Lehti M, Ottaway N, Amburgy S, Raver C, Müller TD, Pfluger PT, Kohli R, Perez-Tilve D,


Seeley RJ, Tschöp MH. Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia. Gut 2013 Oct 9. doi: 10.1136/gutjnl-2013-304583. [Epub ahead of print] (IF 10.73) Cai H, Cong WN, Daimon CM, Wang R, Tschöp MH, Sévigny J, Martin B, Maudsley S. Altered Lipid and Salt Taste Responsivity in Ghrelin and GOAT Null Mice. PLoS One 2013 Oct 4;8(10):e76553. doi: 10.1371/journal.pone.0076553. (IF 3.73) Ward BP, Ottaway NL, Perez-Tilve D, Ma D, Gelfanov VM, Tschöp MH, Dimarchi RD. Peptide lipidation stabilizes structure to enhance biological function. Molecular Metabolism (2013) 2(4):468–479. (IF N/A) Gao Y, Ottaway N, Schriever SC, Legutko B, García-Cáceres C, de la Fuente E, Mergen C, Bour S, Thaler JP, Seeley RJ, Filosa J, Stern JE, Perez-Tilve D, Schwartz MW, Tschöp MH, Yi CX. Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia 2013 Oct 28. doi: 10.1002/glia.22580. [Epub ahead of print] (IF 5.07) Finan B, Ma T, Ottaway N, Müller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, Lockie SH, Smiley DL, Gelfanov V, Yang B, Hofmann S, Bruemmer D, Drucker DJ, Pfluger PT, Perez-Tilve D, Gidda J, Vignati L, Zhang L, Hauptman JB, Lau M, Brecheisen M, Uhles S, Riboulet W, Hainaut E, Sebokova E, Conde-Knape K, Konkar A, Dimarchi RD, Tschöp MH. Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. Sci Transl Med 2013 Oct 30;5(209):209ra151. doi: 10.1126/scitranslmed.3007218. (IF 10.76) Habegger KM, Heppner KM, Amburgy SE, Ottaway N, Holland J, Raver C, Bartley E, Müller TD, Pfluger PT, Berger J, Toure M, Benoit SC, Dimarchi RD, Perez-Tilve D, D'Alessio DA, Seeley RJ, Tschöp MH. GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats. Diabetes 2013 Nov 1. [Epub ahead of print] (IF 8.3) Keuper M, Jastroch M, Yi CX, Fischer-Posovszky P, Wabitsch M, Tschöp MH, Hofmann SM. Spare mitochondrial respiratory capacity permits human adipocytes to maintain ATP homeostasis under hypoglycemic conditions. FASEB J 2013 Nov 12. [Epub ahead of print] (IF 5.704) Schwartz MW, Seeley RJ, Tschöp MH, Woods SC, Morton GJ, Myers MG, D'Alessio D. Cooperation between brain and islet in glucose homeostasis and diabetes. Nature 2013 Nov 7;503(7474):59-66. doi: 10.1038/nature12709. (IF 38.6) Togliatto G, Trombetta A, Dentelli P, Cotogni P, Rosso A, Tschöp MH, Granata R, Ghigo E, Brizzi MF. Unacylated ghrelin promotes skeletal muscle regeneration following hindlimb ischemia via SOD-2-mediated miR-221/222 expression. J Am Heart Assoc. 2013 Dec 5;2(6):e000376. doi: 10.1161/JAHA.113.000376. PMID: 24308935 [PubMed - in process] Free PMC Article. (IF N/A) Clemmensen C, Chabenne J, Finan B, Sullivan L, Fischer K, Küchler D, Sehrer L, Ograjsek T, Hofmann S, Schriever SS, Pfluger PT, Pinkstaff J, Tschöp MH, Dimarchi R, Müller TD. GLP-1/glucagon co-agonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet. Diabetes. 2013 Dec 30. (IF 8.3) Fuente-Martin E, Garcia-Caceres C, Morselli E, Clegg DJ, Chowen JA, Finan B, Brinton RD, Tschöp MH. Estrogen, astrocytes and the neuroendocrine control of metabolism. Rev Endocr Metab Disord. 2013 Dec;14(4):331-8. doi: 10.1007/s11154-013-9263-7. (IF 4.58) Garcia-Caceres C, Tschöp M. The emerging neurobiology of caloric addiction. eLife 2014 Jan 7;3(0):e01928. doi: 10.7554/eLife.01928.2014. (IF N/A)


Gao Y, Luquet S, Tschöp M. The versatile role of tanycytes in metabolic control. Cell Metab 2014. (invited editorial) (IF 14.6)

curriculum vitae matthias h. tschÖp, m.d. · 5 cv matthias h. tschöp, m.d. adhoc reviewer, german...

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