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Curriculum Vitae Sangeeta Khare, MS, PhD,

Research Microbiologist AFFILIATION: Division of Microbiology Phone: 870-543-7519 (office) National Center for Toxicological Research 870-543-7451 (laboratory) US Food and Drug Administration 979-739-7312 (cell) Jefferson-AR-72079 Email: sangeeta.khare@fda.hhs.gov IMMIGRATION STATUS: Naturalized citizen of USA SECURITY CLEARANCE: Department of Justice, Federal Bureau of Investigation, US office of personnel management ACADEMIC QUALIFICATIONS: Degree Field of Study Institution PhD Immunology &

Microbiology All India Institute of Medical Sciences, New Delhi, India

MS Life Sciences Kanpur University, India BS Biology & Chemistry Kanpur University, India PROFESSIONAL POSITIONS: 2010-present Research Microbiologist, National Center for Toxicological Research,

US Food and Drug Administration, Jefferson, AR 2010-present Adjunct Faculty appointment at Department of Veterinary

Pathobiology (VTPB), Texas A&M University, College Station, TX 2006-2010 Assistant Professor (Research), VTPB, Texas A&M University, College

Station, TX 2003-2006 Associate Research Scientist, VTPB, Texas A&M University, College

Station, TX 1999-2003 Assistant Research Scientist, VTPB, Texas A&M University, College

Station, TX 1998-1999 Postdoctoral Research Associate, VTPB, Texas A&M University,

College Station, TX 1996-1997 Postdoctoral Fellow, Department of Microbiology, University of

Saskatchewan, SK, Canada

HONORS AND AWARDS: 2013 Informal recognition award for “outstanding and dedicated effort during

the Division of Microbiology Science Advisory Board Review meeting” National Center for Toxicological Research, Jefferson, AR

2013 Selected as the session convener (Microbiome and human health) for Science Advisory Board site visit for Division of Microbiology

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2013 Selected as Speaker in Gordon Research Conference of Mucosal Health and Disease. Easton, MA

2013 Member of High Pathogen Impact Working Committee US-FDA 2013 Committee member for FDA and NCTR Awards 2013 Selected as a research preceptor for FDA Commissioner Fellow 2012 Selected as a participant to attend National Science Foundation sponsored

workshop “Science: Becoming a messenger” 2010 Selected as a travel award recipient (Burroughs Wellcome Fund) to attend American Society of Microbiology 2008 Selected as one of the participant in the Summer Workshop on Teaching

about Terrorism (emphasis on Biosafety and Biosecurity), University of Oklahoma

2006 S. Edward Sulkin Award at Texas branch ASM for oral presentation (Certificate of Outstanding Scientific Achievement)

2005 Travel Award from “James W McLaughlin Fund” to attend UK-TX-Collaborative Research Initiative in the area of Emerging and Reemerging Diseases

2001 Certificate of Achievement from National Veterinary Science Laboratory, USDA, Iowa; for Johne’s Disease Laboratory approval

1998 Prof. K.P. Sinha – Prof. P.S. Krishnan Award, Association of Clinical Biochemists of India

1997-1999 Research Associate awarded by College of Medicine, University of Saskatchewan, Saskatoon, Canada

1995-1996 Research Associate awarded by Council of Scientific and Industrial Research (CSIR), New Delhi, India

1995 Nominated for P.S. Murthy Award for best paper presentation in the Association of Biochemists of India

1995 Dwarka Prasad Award, All India Institute of Medical Sciences, New Delhi, India

1991-1995 Senior Research Fellow awarded by CSIR, New Delhi, India 1993 CSIR International Travel Grant to attend and present research paper

in14thInternational Congress of Leprosy held at Orlando, Florida 1992 Best Research Presentation Award from Association of Clinical Biochemists

of India 1989-1991 Junior Research Fellow awarded by CSIR, New Delhi, India 1990 Qualified Graduate Aptitude Test of Engineering INVITED TALK May 2014 Invited as a potential symposium speaker for International

Association of Food Protection 2014, Indianapolis, IN November 2013 From Farm to Table: Nanoparticles and Gastrointestinal Health.

Invited talk at Arkansas Children’s Hospital Research Institute, University of Arkansas for Medical Sciences (UAMS). Little Rock, AR

June 2013 Shift in the Gut Commensal Microbiome and Alteration in Gut-Associated Mucosal Immune Response during Chronic Exposure of

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Silver Nanoparticles. Selected as an oral speaker at Gordon Research Conference of Mucosal Health and Disease. Easton, MA

March 2013 Gastrointestinal Health: From Pathogenic Enteric Bacteria to Commensal Gut Microbiome. Roger Williams Medical Center, Providence, RI

November 2012 Invited to attend Division of Gasteroenterology and Hepatology, UAMS Retreat and discuss my perspective as an external collaborator in the area of research, Little Rock, AR

November 2011 Steps Towards Identification of Cytotoxic Biomarkers During Chronic Inflammation in Intestine Associated with Diarrhea, BioNanoTox Conference. Little Rock, AR October 2011 Identification of Cytotoxic Biomarkers During Chronic Inflammation

in Intestine Associated with Diarrhea, Target Meeting 1st world drug discovery online conference

August 2011 Interaction of Nanoparticles with Gastrointestinal Tract: Presentation at NanoCore facility Scientific Advisory Board review, NCTR, Jefferson, AR

June 2011 A Systems Biology Analysis Approach to Dissect Early Events in the Pathogenesis of Chronic Infection at Ileal Mucosa: Division of Gastroenterology & Hepatology, UAMS, Little Rock, AR

May 2011 Biorisk Management in Practice: The Struggle for an Improved Vaccine Against Intracellular Pathogens. In ASM 2011: Biorisk Management of Dual Use Research, New Orleans, LA

May 2011 Identification and Functional Analysis of Non-Typhoidal Salmonella sp. Containing Cytolethal Distending Toxin B, Division of Microbiology, Current Research Seminar Series, NCTR, Jefferson, AR

April 2011 Revealing Immune Consequences of Host-Pathogen Interaction at Intestinal Mucosa Using Systems Biology Approach, University of Arkansas at Little Rock, Little Rock, AR July 2010 Transcriptional analysis of MAP genes contributing to invasion and

persistence in ileal mucosa of cattle, Joint Annual Conference (ADSA®-PSA-AMPA-CSAS-WSASAS-ASAS), Denver, CO

June 2010 Dissection of pathogenic and protective inflammation in gut via Systems Biology analysis approach. Center for Biologics Evaluation and Research, Bethesda, MD March 2010 Systems Biology analysis approach to discover host-pathogen

interaction at intestinal mucosal surface. Department Faculty Seminar, Texas A&M University, College Station, TX

November 2009 Host-pathogen Interaction during MAP infection: Systems Biology analysis approach to dissect early pathogenesis. Infectious Disease Group Meeting- Texas A&M University, College Station, TX November 2009 Functional and genotypic characterization of Mycobacterium paratuberculosis upon invasion in the ileum. Infectious Disease Group Meeting, Texas A&M University, College Station, TX October 2009 Transcriptional analysis of Mycobacterium paratuberculosis contributing to invasion, persistence and survival in ileal mucosa

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of cattle. Johne’s Disease Integrated Program Scientific Advisory Board Meeting August 2009 Mycobacterium paratuberculosis: an emerging zoonotic agent. Informal discussion at University of Saskatchewan, SK August 2009 Three dimensional cell culture model to define the innate responses during mycobacterial infections. Informal discussion at NeuroSciences Inc. Osceola, WI July 2009 Emerging and Re-emerging Diseases of Mucosal Surface: A Systems Biology Analysis Approach to Discover Personalized Medicine. National Center for Toxicological Research, Jefferson, AR January 2009 Emerging and Re-emerging diseases. Faculty Introduction-Texas A&M University, College Station, TX October 2008 Host Responses During Invasion and Persistence of Mycobacterium paratuberculosis in the ileal mucosa of Cattle. Johne’s Disease Intergared Program Scientific Advisory Board Meeting. May 2008 Host-pathogen interactions in acute Mycobacterium avium ssp.

paratuberculosis infection at the mucosal surface of intestine, Mycobacterial Research Group Meeting, Texas A&M University, College Station, TX

November 2007 Temporal changes in the gene expression of the bovine Peyer’s patch infected with Mycobacterium avium ssp. paratuberculosis, Conference of Research Workers in Animal Diseases, Chicago, IL

December 2006 Intestinal pathogens: Role in emerging and re-emerging diseases, All India Institute of Medical Sciences, New Delhi, India

September 2006 Mycobacterial Pathogens: Umbrella of emerging and re-emerging pathogens, Mycobacterial Research Group Meeting, Texas A&M University, College Station, TX

December 2005 Emerging and Re-emerging Diseases: A focus On the Mycobacterial Infections, Texas A&M University, College Station, TX.

November 2004 Bacterial Infections and Immunity, Texas A&M University, College Station, TX

September 2004 Development of a Sensitive and Rapid Test to Identify Mycobacterium avium ssp. paratuberculosis in Clinical Samples, Nucleic Acid Technologies in Animal Health, Texas A&M University, College Station, TX

March 2004 Mycobacterium avium ssp. paratuberculosis: Diagnosis and Gene Expression Profile in the Host. Kanpur University, Kanpur, India

WORKSHOPS/CONFERENCES/MEETINGS ORGANIZED July 2013 Actively participated in the organization of Scientific Advisory

Board Meeting of Division of Microbiology, NCTR, Jefferson, AR June 2008 Two weeks training for scientist from UK (Microarray Lab

Workshop for the gene expression of intracellular bacteria), Texas A&M University, College Station, TX

January 2007 3rd Annual conference of Johne’s Disease Integrated Program at Texas A&M University, College Station, TX

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October 2005 Two weeks extensive training for scientists from Kazakhstan (Techniques in the Molecular detection of Brucella), Texas A&M University, College Station, TX

September 2004 Nucleic Acid Technologies in Animal Health, Texas A&M University, College Station, TX

DEVELOPMENT AND TRANSFER OF TECHNOLOGY:

• Developed a highly sensitive and specific real-time PCR based diagnostics test to identify Mycobacterium avium ssp. paratuberculosis (MAP) in feces, milk and tissue samples. This test has been approved by USDA as one of the Johne’s disease diagnostic test and has been transferred to Texas Veterinary Medical Diagnostic laboratory, College Station-TX

• Made recommendations for transport and freezing of clinical samples for Johne’s disease testing

• Submitted Gene Expression Omnibus (GEO) for the host response to following organisms to NCBI. These submissions will be publicly available once the manuscripts associated with these data are published.: -Mycobacterium avium ssp. paratuberculosis and Salmonella Typhimurium,

COURSE DEVELOPMENT Laboratory Biosafety and Biosecurity (VTMI689 and VTPB489) at Texas A&M University I have established a Laboratory Biosafety course for undergraduates and graduates. The Objectives of the course are:

• In-depth training of the laboratory biosafety and biosecurity • Familiarity with the risk assessments while working in the biohazard laboratory • Theoretical and practical knowledge of working in the BSL- 1 and 2 laboratories • Theoretical knowledge of working in BSL-3 laboratory • How to protect yourself, others and environment while conducting an experiment in

biohazard laboratory • Writing Standard Operating Procedures • Understanding of completing the forms related to research involving animals

(Animal Use Protocol), human (Institutional Review Board) and hazardous materials, Select Agents or recombinant DNA (Institutional Biosafety Committee)

Microbes and Bioterrorism: Facts vs Fiction (UPAS 181) at Texas A&M University This class is in the seminar format. The objectives of the course are: -To understand the great world of microbe. -How to protect yourself, others and environment from microbes. -Distinguish between bioterrorism, biowarfare, and biocrimes. -Student will identify and articulate her/his educational goals in the area of

Microbiology

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RESEARCH SUPPORT Approved protocols at NCTR

• Interaction of Nanoparticles with Gastrointestinal Tract (Role: PI) • Assessment of Size and Shape Dependent-Toxicity of Silver Nanoparticles as

Measured by Changes in the Permeability at the Gastrointestinal Surface (Role: PI)

Submitted protocols at NCTR • Isolation and Molecular Characterization of Vibrio parahemolyticus O3:K6

Serovariants From Imported Seafood (Role: Co PI) • Toxicity of graphene on the population of rat intestinal microbiota (Role: PI)

Approved concept papers at NCTR • Evaluation of potential antimicrobial resistance selection in human intestinal

microbiota following long-term exposure to residual concentrations of antimicrobial drugs as part of human food safety assessment (Role: PI)

• Nonclinical modeling and risk assessment of FDA-regulated nanocrystal drugs (Role: Co PI)

Submitted concept papers at NCTR:

• Effects of high-energy electronic (E-beam) irradiation on survival and immunogenicity of zoonotic pathogen Mycobacterium paratuberculosis: a potential for vaccine development (Role: PI)

• Linkage of gut microbiota with extraintestinal manifestations in Inflammatory Bowel Disease (Role: PI)

• Correlation of Food Additives, NSAIDs and Intestinal Microbiota with the Prevalence of Fibromyalgia and Irritable Bowel Syndrome in Female (Role: PI) Funded (completed) Texas Animal Health Commission Sangeeta Khare (PI) August 2005-December 2007 Title: Comparative analysis of virulence of Mycobacterium paratuberculosis isolated from subclinical and clinically infected beef & dairy cattle

Texas Animal Health Commission Allen Roussel (PI) Sangeeta Khare CO-PI

August 2005-December 2007

Title: Effect of storage on ability to detect Mycobacterium paratuberculosis from diagnostic fecal samples

Texas A&M University-CONACyT: Collaborative Research Grant

Allison R-Ficht (PI) Sangeeta Khare (CO-PI)

August 2005-July2007

Title: Validation and development of diagnostic assays for Mycobacterium paratuberculosis in cattle and human.

Johnes’ Disease Integrated Program (USDA)

Sangeeta Khare (PI) January 2006-May 2009

Title: Phagocytosis and persistence of Mycobacterium paratuberculosis in macrophages isolated from beef and dairy cattle

Formula Animal Health (USDA) Sangeeta Khare (PI) June 2007-May 2009 Title: 3-D Cell Culture Model for the Study of the Host Innate Response to Infection by Mycobacterium paratuberculosis

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Texas AgriLife Research Vector-Borne Disease Program

L. Garry Adams and Sangeeta Khare (PI)

November 2009-October 2011

Title: Immunobiology & Kinetics of Protective Immunity against Rift Valley Fever Virus This project is aimed to define and compare the kinetics and immunobiology of protective immunity of MP-12 and vaccinia-vectored RVF vaccines in sheep.

SUPERVISORY SKILLS Trained undergraduate students, graduate students, residents, postdoctoral fellows, visiting scientists and FDA Commissioner’s Fellow. The following students/scientists were directly associated with me: Dr. Aschalew Z. Bekele FDA Commissioner’s Fellow (November 2013 onwards) Ms Katherine Williams ORISE Fellow (September 2012 onwards) Ms. Jessica Milner ORISE Summer Fellow (Summer 2012) Ms. Abhilasha Gokulan High School Science Fair Project (Fall 2011) Mr. Ezat Hussain Graduate student at UALR (Fall 2011 onwards; trained for

various techniques) Ms Diamond Shelman ORISE Summer Fellow (Summer 2011) Mr. Caesar Romeno 485 student with undergraduate thesis, Texas A&M University,

College Station-TX (Fall 2009-Spring 2010) Ms. Sharanya MS (Biotechnology student at Texas A&M University, College Sivanandan Station-TX (Spring 2009 to Spring 2010) Dr. Sophie Smithers Postdoctoral fellow and visiting scientist from Defense Science

and Technology Laboratory, Porton Down, Salisbury, Wiltshire UK (Summer 2008)

Mr. Anuj Vyas Undergraduate student Texas A&M University, College Station, TX (Spring 2008)

Dr. Alihu A. Cortes Visiting scientist from Mexico (February 2007-April 2007) Ms. Latietia David Exchange MS Student from France (April 2006 to 2007) Ms. Mukta Mann MS Biotechnology student Texas A&M University, College

Station, TX (Spring-Summer 2006) Ms. Lindsey Syler DVM/PhD Student at Texas A&M University, College Station,

TX (Summer-fall 2005) Dr. Pushpa Samkutty ORISE-Visiting Scientist and Associate Professor from

Southern University, Baton Rouge, LA (Department of Homeland Security sponsored summer research Program), 10 weeks during Summer of 2005

Ms. Shonette Matthews ORISE-Visiting Student from Southern University, Baton Rouge, LA (Department of Homeland Security sponsored summer research Program), 10 weeks during Summer of 2005

Mr. Sergio Garbaccio Visiting scientist from Argentina (Summer 2003) Mr. Adam Melton 485 Student, Texas A&M University, College Station, TX (Spring

2003) Mr. Omar Villanueva 485 Student, Texas A&M University, College Station, TX (Fall

2002) Mr. Brat Muller 485 Student, Texas A&M University, College Station, TX (Fall

2001)

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CERTIFICATE OF COMPLETION AND WORKSHOPS ArrayTrack, EMEN2, and other Bioinformatics Tools Training NCTR, Jefferson, AR (August 2013).

Science: Becoming the Messenger Selected to attend the Workshop organized by National Science Foundation, September 26’ 2012)

Office of Women Health Annual NCTR, Jefferson, AR Conference (August 2012).

Advanced Array Track training NCTR, Jefferson, AR (1 day course—October 2011)

Array Track training NCTR, Jefferson, AR (2 days course in 2010).

FDA and Nanotechnology: Materials, Properties, Evaluation, and Applications Attended via video-conference from FDA Head Quarters (2 full day course-September 1 and 14-2011)

Nanotechnology: FDA & USG Activities and Perspectives Attended via video-conference from FDA Head Quaters-(September 22 and 29’ 2011)

Toxicogenomics Integrated with Environmental Sciences (TIES-2011) Conference. The Biology and Bioinformatics behind Environmental and Toxicological Influences (Attended via video-conference from FDA Head Quaters). (September 15-16, 2011)

1st Annual Hands-on Workshop in E-Beam and X-ray Irradiation Technologies. at National Center for Electron Beam Research Food Technology Facility for Electron Beam and Space Food Research. Texas A&M University, College Station, TX (April 2010)

Inquiry Based Learning-Grading Assessment Workshop. Texas A&M University, College Station, TX (December 2009)

Texas A&M AgriLife Food Safety Initiative Workshop. Texas A&M University, College Station, TX (September 2009)

2-D Gel Workshop and Proteomics Workshop. A week long workshop organized by The Texas A&M University, College Station, TX. (June 2009)

First Workshop on Genome Bioinformatics 10 day workshop organized by The Texas A&M University, College Station, TX. (June 2009)

Blood Borne Pathogen Training. Texas A&M University, College Station, TX. June 2009

Summer Workshop on the Teaching about Terrorism a week long workshop organized by The University of Oklahoma, Norman, OK (June 23-30’ 2008)

Laboratory Biosafety Level-3 Training a week long training program organized by The University of Texas medical branch, Galveston, TX. (August 14-17’ 2007)

NIH Guidelines and the Oversight of recombinant DNA Research organized by NIH at Texas A&M University, College Station, TX. (August 24th 2007)

Select Biological Agent and Toxins Program Training at Texas A&M University, College Station, TX. (June 1st 2007)

Good Laboratory Practices (GLP) course organized by The University of Texas medical branch-Searly Center for Vaccine Development & Research Services, Galveston, TX. (September 13th 2004)

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General Radiation Safety Training by Environmental health and Safety Department, Texas A&M University, College Station, TX. (August 30th, 2002)

MICE: Basic Handing and Techniques Texas A&M University, College Station, TX. (January 2002)

Aseptic Techniques with Rodent Survival Surgery Texas A&M University, College Station, TX. (January 2002)

INDO-US course on the Basics of Immunology-All India Institute of Medical Sciences, New Delhi, India

International Union of Immunological Society Course on Advanced Immunology- organized by All India Institute of Medical Sciences, New Delhi, India

MEMBERSHIP IN SCIENTIFIC SOCIETIES American Society of Microbiology International Society of Infectious Diseases Johne’s Disease Integrated Program Conference of Research Workers in Animal Diseases Indian Immunology Society REVIEWER Official Reviewer Informal review: American Journal of Veterinary Research Journal of Wild Life and Diseases Vaccine Microbiology Veterinary Pathology Biochemical genetics PloS One Infection and Immunity Microbes and Infection Invitation to Review Proposals

• Binational Agriculture Research and Development Fund 2012 • Formula Animal Health Grants- U.S. Department of Agriculture 2010, • U.S. Department of Agriculture Cooperative State Research, Education and Extension

Service-National Research Initiative-Coordinated Agricultural Project-Johne's Diseas Integrated Program 2008, 2009, 2010

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SELECTED PEER-REVIEWED PUBLICATIONS (in reverse chronological order) 1. Gokulan, K., Khare S., Rooney A., Han J., Lynne A., Foley S. Impact of Plasmids, including

those EncodingVirB4/D4 Type IV Secretion Systems, on Salmonella enterica Serovar Heidelberg Virulence in Macrophages and Epithelial Cells. Accepted in PLoSOne, 2013, 8(10):e77866

2. Han J., Gokulan, K., Barnette D., Khare S., Rooney A., Deck J., Nayak R., Stefanova R., Foley S. Evaluation of Virulence and Antimicrobial Resistance in Salmonella enterica serovar Enteritidis Isolates from Humans and Chicken- and Egg-Associated Sources. Accepted in Foodborne Pathogens and Disease, 2013, FPD-2013-1518.R2

3. Sun, J., Schnackenberg, L., Khare, S., Yang, X., Greenhaw, J., Mendrick, D.L., Salminen, W.,

Beger, R. Evaluating effects of penicillin treatment on the metabolome of rats. Journal of Chromatography B, 2013; 932:134-43

4. Shakir. Z, Khan, S., Sung, S., Khare, S., Khan, A., Steele, R. and Nawaz, M. Molecular Characterization of Fluoroquinolone-Resistant Aeromonas spp. Isolated from Imported Shrimp. Applied and Environmental Microbiology 2012; 78(22):8137-41

5. Khare, S., Lawhon, S.D., Drake, K.L., Nunes, J.E.S., Figueiredo, J.F., Rossetti C.A., Gull T., Everts R.E., Lewin H.A., Galindo, C.L., Garner, H.R., Adams, L.G. Systems Biology Analysis of Gene Expression during In Vivo Mycobacterium avium paratuberculosis Enteric Colonization Reveals Role for Immune Tolerance. PLoS One 2012; 7(8): e42127

6. Lawhon, S. D., Khare. S., Rossetti, C. A., Everts, R. A., Galindo C. L., Luciano, S. A., Figueiredo. J. F.,Nunes, J. E. S., Gull, T. Davidson, G. S., Drake, K., Garner, H. R., Lewin, H. A., Bäumler, A. J., Adams. L. G., Role of Spi-1 Secreted Effectors, Sipa, Sopa, Sopb, Sopd, And Sope2, in Acute Bovine Response to Salmonella Enterica serovar typhimurium. PLoS One. 2011;6(11):e26869

7. O’Shea, B., Khare, S., Bliss, K., Klein, P., Ficht, T.A., Adams, L.G., Rice-Ficht, A.C. Amplified Fragment Length Polymorphism Reveals Isolation specific Epigenetic Distinctions Between Mycobacterium avium subspecies paratuberculosis Isolates of Varying Invasion Types. Journal of Clinical Microbiology 2011;49:2222-9

8. Adams, L. G., Khare, S., Lawhon, S.D., Rossetti, C.A., Lewin, H. A., Lipton M. S., Turse, J. E., Wylie, D.C., Bai, Y., Drake, K.L. Enhancing the Role of Veterinary Vaccines Reducing Zoonotic Diseases of Humans: Linking Systems Biology with Vaccine Development. Vaccine 2011;29:7197-206

9. Adams, L. G., Khare, S., Lawhon, S.D., Rossetti, C.A., Lewin, H. A., Lipton M. S., Turse, J. E., Wylie, D.C., Bai, Y., Drake, K.L. Multi-Comparative Systems Biology Analysis Reveals Time-Course Biosignatures of in Vivo Bovine Pathway Responses to B. melitensis, S. enterica Typhimurium and M. avium paratuberculosis. BMC-Proceedings BMC Proceedings 2011, 5(Suppl 4):S6

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10. Bai, Y., Wylie, D.C., Adams, L. G., Khare, S., Lawhon, S.D., Rossetti, C.A, Drake, K. L.. BioSignature Discovery System (BiosignatureDS™): a next generation solution for OMICS analysis and modeling in drug discovery and personalized medicine. Seralogix Whitepaper; 2012

11. Khare, S., Libby S.J., Alali. W. Zhang, S., Adams. L.G. Role of intimin based recombinant salmonella vaccine in prevention of E.coli O157:H7 infection in cattle. BMC Veterinary Research. 2010; 7:35-44

12. Dhavala, S. S., Datta, S., Mallick, B. K., Carroll, B. J., Khare, S., Lawhon, S. D., Adams, L. G. Bayesian Modeling of MPSS Data: Gene Expression Analysis Of Bovine Salmonella Infection. Journal of American Statistical Association 2010; 105: 1-12

13. Tran, Q. T. , Gomez, G., Khare, S., Lawhon, S.D., Raffatellu, M., Bäumler, A.. J., and Adams, L.. G. Salmonella enterica serotype Typhi Vi capsular antigen is expressed after invasion of intestinal epithelial cells and bovine Peyer’s Patch. Infection & Immunity, 2010; 78:527-535

14. Nunes J. E. S., Lawhon S, Rossetti, C. A., Khare S.,Figueiredo J. F., Gull, T. A., Burghardt, R.C., Baumuler, A.J., Andrews-Polymenis, H. L. and Adams, L.G. Morphologic and Cytokine Profile Characterization of Salmonella typhimurium Infection in Calves with Bovine Leukocyte Adhesion Deficiency. Veterinary Pathology, 2010;47:322-33

15. Khare S., Nunes J. E. S, Figueiredo J. F., Lawhon S, Ficht T. A., Rice-Ficht A. C., Adams L. G. Early Phase Morphological Lesions and Transcriptional Responses of Bovine Ileum Infected with Mycobacterium avium subsp. paratuberculosis. Veterinary Pathology, 2009; 46:717–728

16. Figueiredo, J.F, Lawhon, S.D, Gokulan K, Khare, S, Raffatellu, M, Burghardt, R.C., Tsolis, R.M.,Baumuler, A.J., McCormick, B. and Adams, L.G. Salmonella Typhimurium SipA induces CXC-chemokines expression and protein phosphorylation independent of TLR-5. Microbes & Infection, 2009;11:302-10

17. Khare, S., Osterstock, J., Roussel, A., David, L. and Adams, L.G. Effects of shipping and storage conditions of fecal samples on the viability of Mycobacterium paratuberculosis. Journal of Clinical Microbiology. 2008; 46:1561-1562

18. Khare, S., Hondalus, M., Nunes, J.E.S., Bloom, B.R. and Adams L.G. Mycobacterium bovis leuD auxotroph-induced protective immunity of cattle against intranasal M. bovis Ravenel challenge. Vaccine. 2007; 25:1743-1755

19. Gokulan, K., Khare, S., Ronnings, D.R., Linthicum, D.S., Rupp, B. and Sacchettini, J. C. Identification of key residues of the NC6.8 Fab antibody fragment binding to synthetic sweeteners: Crystal structure of NC6.8 co-crystallized with high potency sweetener compound SC45647. Biochemistry. 2005;44:9889-98

20. Raffatellu, M., Wilson, P.R., Chessa, D., Andrews-Polymenis, H., Lawhon, S.D., Khare, S., Adams, L.G. and Baumler, A.J. SipA, SopA, SopB and SopE2 Contribute to Salmonella

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enteritica serotype typhimurium invasion of Epithelial Cells. Infection and Immunity. 2005;73:146-154

21. O’Shea, B., Khare, S., Bliss, K., Klein, P., Ficht, T.A., Adams, L.G., Rice-Ficht, A.C. Genotyping and Characterization of Mycobacterium avium ssp. paratuberculosis Using Amplified Fragment Length Polymorphism. Journal of Clinical Microbiology. 2004;42:3600-3606

22. Khare, S., Ficht, T.A., Santos R.L., Romano, J., Ficht, A.R., Zhang, S., Grant I.R., Libal, M., Hunter, D., Adams, L.G. Rapid and sensitive detection of Mycobacterium avium ssp. paratuberculosis in bovine milk and feces an immunomagnetic bead beat-conventional and real time PCR. Journal of Clinical Microbiology. 2004;42:1075-1081

23. Zhang, S., Nunes, J.E.S., Adams, L.G., Khare, S., Tsolis R.M., Baulmer, A.J. Secreted effector proteins of Salmonella enterica serotype Typhimurium elicit host specific chemokine profiles in animal models of typhoid fever and enterocolitis. 2003. Infection and Immunity. 71:4795-4803

24. Khare, S., Banai, Y., Gokulan K., Linthicum D.S., Modiano, J.F., Early changes in metabolism of leukemic cell lines upon induction of apoptosis by cytotoxic drugs. European Journal of Pharmacology. 2003;465:23-30

25. Humphries A.D., Raffatellu M., Winter S., Weening E.H., Kingsley R.A., Droleskey R., Zhang S., Figueiredo J.F, Khare S., Nunes J.E.S., Adams L.G, Tsolis R.M., Baumler A.J.. The use of flow cytometry to detect expression of subunits encoded by 11 Salmonella enterica serotype Typhimurium fimbrial operons. Molecular Microbiology. 2003;48:1357-76

26. Khare, S., Gokulan, K., Linthicum, D.S. Cellular responses of NG108-15 and SK-N-MC lines to sweet and bitter tastants as measured by extracellular acidification rates. Journal of Neuroscience Research. 2001;63:64-71

27. Zhang, A.J., Khare, S., Gokulan, K., Linthicum, D.S., Burgess, K. Dimeric beta-turn peptidomimetics as ligands for the neurotrophin receptor TrkC. Bioorganic and Medicinal Chemistry Letters. 2001;11:207-210

28. Khare, S., Gokulan, K., Linthicum, D.S. Vasoactive amine responses in murine cerebrovascular endothielial cells as measured by extracellular acidification rates. Journal of Neuroscience Research 2000;60:356-361

29. Gokulan, K., Khare, S., Rao, D.N. Increase in the immunogenicity of HIV peptide antigens by chemical linkage to polytuftsin (TKPR) 40. DNA and Cell Biology 1999;18:623-630

30. Gokulan, K., Khare, S., Rao, D.N. Construction of chimeric immunogens: Bioactive fragment of human IL-1b or polytuftsin (PT) capable of eliciting immune responses to HIV peptides. Indian Journal of Clinical Biochemistry 1998; 13:116-123

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31. Khare, S., Bhutani, L.K., Rao, D.N. Quantitative assessment of tuftsin receptor expression and second messenger during in vitro differentiation of peripheral blood derived monocytes of leprosy patients. Molecular and Cellular Biochemistry 1997;171:1-10

32. Khare, S., Bhutani, L.K., Rao, D.N. Release of reactive nitrogen intermediates from the peripheral blood derived monocytes/macropahges of leprosy patients stimulated in vitro by tuftsin. Leprosy Review 1997;68:16-24

33. Khare, S., Bhutani, L.K., Rao, D.N. Reactive oxygen intermediates during macrophage activation with tuftsin derived from peripheral blood of leprosy patients. Leprosy Review 1993;64:208-218

34. Khare, S., Bhutani, L.K., Rao, D.N. Modulation of monocytes/macrophages of leprosy patients by tuftsin for biochemical and immunogenic functions. International Journal of Leprosy 1993;68:16-24

35. Khare, S., Iyer, R.R., Rao, D.N. Modulation of peripheral blood derived monocytes-macrophages of leprosy patients for immunogenic functions in vitro by tuftsin. Indian Journal of Medical Microbiology 1993;10:164-175

36. Kaur, J., Khare, S., Bhutani, L.K., Rao, D.N. Enzyme immunoassay of phagocytosis stimulating tetrapeptide, tuftsin in normal and leprosy sera. Int. J. Leprosy. 59, 1991; 576-81,

CHAPTERS/ABSTRACTS IN BOOKS: 1. Khare, S., Williams, K. and Gokulan, K. Nanotechnology. Accepted in Encyclopaedia of

Food Microbiology, 2nd Edition, Elsevier 2014

2. Khare, S., and Rafii, F. Microflora of Intestine | Detection and enumeration of probiotic cultures,” Accepted in Encyclopaedia of Food Microbiology, 2nd Edition, To be published by Elsevier 2014

3. Gokulan, K., Khare, S., and Cerniglia, C. Metabolic Pathways | Production of secondary metabolites of bacteria. Invited chapter in Press: Encyclopaedia of Food Microbiology, 2nd Edition, To be published by Elsevier 2014

4. Khare S., Nunes J.E.S, Figueiredo J.F., Lawhon S.D., Ficht T.A., Rice-Ficht A.C., Adams L.G. Early host responses during infection of Mycobacterium avium subsp. Paratuberculosis in bovine ligated ileal loop. In International symposium on New Frontiers in Tuberculosis Research Macmillan Advanced Research Series. ISBN 10:0230-63004-9. 2006: p109

5. Ficht, T.A., Adams, L.G., Khare, S., O’Shea, B. and Rice-Ficht, A.C. Global analysis of the Mycobacterium avium ssp. paratuberculosis genome and model systems exploring host-agent interaction. In “Pre-harvest and post-harvest food safety: Contemporary issues and future directions” Blackwell publishing, Ames, IA, 2004: 87-99

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6. Kaur, J., Khare, S., Bhutani, L.K., Rao, D.N. Enzyme Immunoassay of phagocytosis stimulating tetra peptide-tuftsin in normal and leprosy sera. In Immunology Perspectives in Reproduction and Infection, Oxford & IBH Publishing Co. Pvt. Ltd. 1991;327-335

MANUSCRIPTS (under review or preparation): 1. Mezel, E., Akiyama, T., and Khan A. Khare, S. Identification and Functional analysis of

Non-Typhoidal Salmonella (NTS) Serovar Containing Cytolethal Distending Toxin. (revised manuscript to be submitted to Applied and Environmental Microbiology)

2. Shelman, D., Williams, K. W., Gokulan, K., Akiyama, T., Khan, A. and Khare, S. Activation of Host Cell Death Pathways by Non-Typhoidal Salmonella Serovar Containing Cytolethal Distending Toxin. (revised manuscript to be submitted to Plos One)

3. Rossetti, C. A., Drake, K. L., Lawhon, S.L., Nunes, J., Gull, T., Khare, S., Everts, R., Lewin, H. and Adams, L. G. Temporal Global Gene Expression Analysis of the in vivo Initial Interactions of both Brucella melitensis and the Bovine Host. (revised manuscript to be submitted to Plos One)

4. Williams, K. W., Milner, J., Gokulan, K., Boudreau, M., Cerniglia, C. and Khare, S. Chronic Exposure to Silver-Nanoparticles Leads to Alteration in Intestinal Microbiota and Gut-Associated Mucosal Immunity

5. Nawaz, M., Sung, K., Gokulan, K., Khare, S., Khan, S., Steele, R. Characterization of Novel Point Mutations in Virulent, Fluoroquinolone-Resistant Vibrio parahemolyticus Isolated from Imported Shrimp

6. Imam, M., Khare, S., Paredes, A., and Boudreau. M. Impact of Silver Nanoparticles on Bacterial Species Isolated from Gastrointestinal Tract of Sprague Dawley Rats.

7. Khare, S., Nunes, J. E. S., Lawhon, S. D., Rosetti, C. A., Figueiredo, J. F., Gull, T., Drake, K., Everts, R. A., Lewin, H. A., Galindo, C. L., Garner, H. A. and Adams, L. G. A Systems biology analysis approach of gene expression distinguishes the host responses during Mycobacterium aviun ssp. paratuberculosis and Mycobacteriun avium ssp. avium that leads to persistent or transient infection respectively

8. Nunes, J., Lawhon, S.D., Rossetti, C.A., Khare, S., Figueiredo, J.F., Gull, T., Burghardt, R.C., Bäumler, A.J., Tsolis, R.M., Andrews-Polymenis, H.L., Adams, L.G. Host temporal global gene expression analysis in Salmonella Typhimurium-infected calves with bovine leukocyte adhesion deficiency

9. Nunes, J., Lawhon, S.D., Rossetti, C.A., Khare, S., Figueiredo, J.F., Gull, T., Burghardt, R.C., Bäumler, A.J., Tsolis, R.M., Andrews-Polymenis, H.L., Adams, L.G. Analysis of cytokine profiles in Salmonella Typhimurium-infected calves with bovine leukocyte adhesion deficiency by laser capture microdissection

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SELECTED PRESENTATIONS AT CONFERENCES (ORAL OR POSTER)

1. Williams, KW, Milner, J, Gokulan, K, Boudreau, M, Cerniglia, C, Khare, S. Silver nanoparticles and the gastrointestinal system: ex vivo, in vivo and in vitro studies examining permeability, microflora, and host response. Global Summit on Regulatory Science – Little Rock, AR. September 2013

2. Williams, KW, Milner, J, Gokulan, K, Boudreau, M, Cerniglia, C, Khare, S. Silver nanoparticles and the gastrointestinal system: in vivo and in vitro studies examining permeability, microflora, and host response, Microbiology-Science Advisory Board-Jefferson-AR. July 2013

3. Williams, KW, Milner, J, Gokulan, K, Boudreau, M, Cerniglia, C, Khare, S. Shift in the Gut Commensal Microbiome and Alteration in Gut-Associated Mucosal Immune Response During Chronic Exposure of Silver Nanoparticles. Gordon Research Conference-Easton-MA. June 2013

4. Milner J, Boudreau M, Cerniglia C and Khare S. Chronic Exposure to Silver-Nanoparticles Leads to Alteration in Intestinal Microbiota and Gut-Associated Mucosal Immunity. IVth Annual Conference on Nanotechnology for Health Care. Petit Jean Mountain-AR. September 2012

5. Milner J, Boudreau M, Cerniglia C and Khare S. Assessment of Intestinal Microbial Community and Mucosal Immune Response During Chronic Exposure to Silver Nanoparticle. IVth Annual Conference on Nanotechnology for Health Care. Petit Jean Mountain-AR. September 2012

6. Gokulan, K., Khare S., Rooney A., Han J., Lynne A., Foley S. Involvement of Type IV Secretion System (T4SS) Encoding Plasmids in the Virulence of S. enterica serovar Heidelberg. 2ND Annual Foods Program Science and Research Conference Food and Feed Safety and Nutrition Research: The Foundation for Regulatory Policy. August 1-2, 2012

7. Han J., Gokulan, K., Barnette D., Khare S., Rooney A., Deck J., Nayak R., Stefanova R., Foley S. Evaluation of Virulence and Antimicrobial Resistance in Salmonella enterica serovar Enteritidis Isolates from Poultry-Associated and Human Sources. 2ND Annual Foods Program Science and Research Conference Food and Feed Safety and Nutrition Research: The Foundation for Regulatory Policy. August 1-2, 2012

8. Khare S, Shelman D, Gokulan K, Akiyama T, Khan A. Activation of Host Cell Death Pathways by Non-Typhoidal Salmonella (NTS) Serovar Containing Cytolethal Distending Toxin. 111 American Society of Microbiology General Meeting. San Francisco, June 2012

9. Gokulan K, Khare S, Rooney AW, Han J, and Foley SL. Involvement of T4SS Encoding Plasmids in the Virulence of S. enterica serovar Heidelberg. 111 American Society of Microbiology General Meeting. San Francisco, June 2012

10. Foley SL, Han J, Barnette D, Gokulan K, Khare S, Rooney AW and Nayak R. Evaluation of Virulence and Antimicrobial Resistance in Salmonella enterica serovar Enteritidis

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Isolates from Poultry-Associated and Human Sources. 111 American Society of Microbiology General Meeting. San Francisco, June 2012

11. Khare S. Novel Approach to identify Cytotoxic Biomarkers during Inflammation in Intestine Associated with Diarrhea. Research and Regulatory Aspects of Food Safety, Jefferson, April 2012

12. Khare S, Akiyama T, Mezal E, Khan A. Identification and Functional Analysis of Non-Typhoidal Salmonella Spp. Containing Cytolethal Distending Toxin B. 110 American Society of Microbiology General Meeting. New Orleans, 2011

13. Khare S, Drake, K, Nunes JES, Lawhon SD, Figueiredo JF, Rosetti CA, Gull T, Everts RA, Lewin HA, and Adams LG. Transcriptional Analysis of MAP Genes Contributing to Invasion and Persistence in Ileal Mucosa of Cattle. Joint Annual Conference (ADSA®-PSA-AMPA-CSAS-WSASAS-ASAS), Denver-CO. July 2010

14. Khare S, Drake, K., Tran, Q., Adams, LG. Mycobacterium paratuberculosis infection Causes Change in the Epithelial Cells Permeability: Correlation with the Cell Adhesion Molecule and Tight Junction Molecule Expression. International conference of paratuberculosis. Minneapolis-MN. August 2009

15. Khare S, Nunes JES, Lawhon SD, Figueiredo JF, Rosetti CA, Gull T, Everts RA, Lewin HA, Galindo CL, Garner HA and Adams LG. A Systems Biology Analysis Approach for Detection of Sequential Changes in the Gene Expression of the Bovine Peyer’s Patch Infected with Mycobacterium aviun ssp. paratuberculosis. 108 American Society of Microbiology General Meeting. Boston, 2008

16. Khare S, Nunes JES, Lawhon SD, Figueiredo JF, Rosetti CA, Gull T, Everts RA, Lewin HA, Galindo CL, Garner HA and Adams LG. A Comparative Analysis of Temporal Changes in the Gene Expression of the Neonatal Peyer’s Patch Infected with Mycobacterium aviun ssp. paratuberculosis or Mycobacteriun avium ssp. avium. 4th Annual Conference of Johne’s Disease Integrated Program. Michigan, 2008

17. Khare S, Nunes JES, Lawhon SD, Figueiredo JF, Rosetti CA, Gull T, Everts RA, Lewin HA, Galindo CL, Garner HA and Adams LG. Temporal Changes in the Gene Expression of the Bovine Peyer’s Patch Infected with Mycobacterium aviun ssp. paratuberculosis. Conference of Research Workers in Animal Diseases, Chicago 2007

18. Khare S, O’Shea B, Arenas A, Nunes JES, Lawhon SD, Figueiredo JF, Rosetti CA, Gull T, Rice-Ficht AC, Adams LG. Involvement of Dendritic Cells in the Mycobacterium avium paratuberculosis Infection in the Bovine Ligated Ileal Loop Model. 3rd Annual Conference of Johne’s Disease Integrated Program. College Station, 2007

19. O’Shea B, Khare S, Klein P, Adams LG, Ficht TA, Rice-Ficht AC, Genetic Profiles of Cell-Tissue Associated Mycobacterium avium subspecies paratuberculosis Isolates Suggest a Bacterial Selection During Infection. 3rd Annual Conference of Johne’s Disease Integrated Program. College Station, 2007

20. Khare S, Nunes JES, Figueiredo JF, Lawhon SD, Rossetti C, Gull A, Rice-Ficht AC, Adams

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LG. Early Host Responses During Infection of Mycobacterium avium subspecies paratuberculosis in Bovine Ligated Ileal Loop Model. International Symposium on New Frontiers in Tuberculosis Research, New Delhi, India 2006

21. Khare S, Lawhon SD, Haudenschild CD, Davidson GS, Figueiredo JF, Rossetti CA, Nunes JES, Gull T, Thomas TL, Bäumler AJ and Adams LG Gene Expression Analysis by Massively Parallel Signature Sequencing in Bovine Ligated Ileal Loop During Salmonella Infection. Texas Branch Meeting of American Society of Microbiology General Meeting. Galveston, 2006 Received S. Edward Sulkin Award-Honorable mention (Certificate of Outstanding Scientific Achievement ) at Texas branch ASM for oral presentation,

22. Lawhon SD, Khare S, Rossetti CA, Galindo C, Everts R, Figueiredo JF,. Nunes JES, Gull T, Haudenschild C, Davidson GS, Garner HR, Drake K, Lewin HA, Bäumler AJ, and Adams LG. Bovine Gene Expression in Acute Salmonella enerica Serovar Typhimurium Infection Analyzed by MPSS and Microarray. Food Safety Research and Response Network, Chicago, 2006

23. Khare S, Lawhon SD, Haudenschild CD, Davidson GS, Figueiredo JF, Rossetti CA, Nunes JES, Gull T, Thomas TL, Bäumler AJ and Adams LG In vivo Gene Expression Profile of Bovine Ileal Peyer's Patch Infected with Salmonella enterica serovar Typhimurium Analyzed by Massively Parallel Signature Sequencing. 106 American Society of Microbiology General Meeting. 2006

24. Khare S, Nunes JES, Figueiredo JF., Lawhon SD, Ficht TA, Rice-Ficht AC, Adams LG. Early Host Responses to Mycobacterium Avium Subsp. Paratuberculosis. Analyzed by The Bovine Ileal Loop Model. Fifth McLaughlin Symposia in Infection & Immunity, Galveston, 2005. Received travel award from “James W McLaughlin Fund” to attend UK-TXCollaborative Research Initiative in the area of Emerging and Reemerging Diseases.

25. Khare S, Figueiredo JF, Lawhon S, Rossetti C, Nunes JES, S. Gull T, Ficht A.C Rice Ficht, and Adams LG. Gene Expression Analysis of Mycobacterium avium subspecies paratuberculosis Infected Peyer’s Patches in Ligated Bovine Ileal Loops. 104 American Society of Microbiology General Meeting. 2004

26. Lawhon SD, Khare S, Figueiredo J, Rossetti C, Nunes JES, Gull T, Baumler A and Adams LG. Induction of interleukin 6 and Interleukin 15 by Salmonella entrrica Serovar Typhymurium in calves. 104 American Society of Microbiology General Meeting. 2004

27. Rossetti CA, Khare S, Lawhon S, Adams LG. Gene Expression of Brucella abortus-Infected Macrophages from Cattle Naturally Resistant to Brucellosis. 104 American Society of Microbiology General Meeting. 2004

28. Nunes JES, Khare S, Figueiredo J, Lawhon S, Rosetti C, Gull T, Ficht T, Rice-Ficht A, Adams, G. Morphologic and Host Gene Expression Analysis of Experimentally Mycobacterium avium subspecies paratuberculosis Infected Peyer’s Patches in Ligated Bovine Ileal Loops. In: 55th Annual Meeting of the American College of Veterinary

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Pathologists - ACVP & 39th Annual Meeting of the American Society for Veterinary Clinical Pathology - ASVCP, Orlando, FL, 2004

29. Khare S, Figueiredo JF, Lawhon S, Rossetti C, Nunes JES, Zhang S, Ficht TA, Ficht AC, and Adams LG. Establishment of Mycobacterium avium subspecies paratuberculosis Infection and Modulation of Bovine Peyer’s patch gene expression. The Texas Branch of American Society for microbiology. College Station, TX, 2003

30. Raffatellu M, Wilson PR, Zhang S, Humpshries AD, Andrews-Polymenis A, Figueiredo J, Khare S, Lawhon SD, Rossetti C, Adams LG and Baumler A. S. enterica serotype Typhimurium interaction with epithelial cells: comparison of in vivo and in vitro models. The Texas Branch of American Society for Microbiology. College Station, TX, 2003

31. Lawhon SD, Khare S, Josely F, Carlos R, Jairo N and L. Garry Adams. Effects of the Ileal Environment on Salmonella enterica serovar Typimurium. The Texas Branch of American Society for Microbiology. College Station, TX 2003

32. Josely F, Moueimne RB, Khare S. Zhang S, Burghardt RC, Baumler AJ and L. Garry Adams. Down regulation of PMCA Induced by Salmonella Typhimurium in Intestinal Epithelial Cells and its Correlation with Cytosolic Levels of Calcium. The Texas Branch of American Society for Microbiology. College Station, TX 2003

33. Khare S, Zhang S, Nunes JES, Figueiredo JF, Nunes JES, Ficht TA, Ficht AC, and Adams LG. Bovine Ligated Ileal Loops Infected with Mycobacteium avium subspecies paratuberculosis: Ultrastructural Analysis of Peyer’s Patches and Early Changes in Gene Expression Profiles of C-C cytokines and C-X-C cytokines. 103 General Meeting of American Society of Microbiology, Washington DC. 2003

34. Khare S, Ficht TA, Ficht AC-Rice, Romano J, Hunter D and Adams LG. Detection of Mycobacterium avium subspecies paratuberculosis in Milk and Feces Using Immunomagnetic PCR. 102 The American Society for Microbiology General Meeting. St. Louis, MO 2002

35. Khare S, Gokulan K, and Linthicum DS. Vasoactive Amine Responses in Murine Cerebrovascular Endothelial Cells as Measured by Extracellular Acidification Rates. The 39th Conference of Immunologists. Asilomar , CA 2000

36. Khare S, Gokulan K, McGregor R, and Linthicum DS. Use of the Cytosensor Microphysiometer to study Hamster Taste Bud Cells Responses to Sweet Compounds. XXI Association for Chemoreception Science, Sarasota, FL 1999

37. Khare S, Bhutani LK, Rao, DN. Modulation of Leprosy Derived Macrophages by Tuftsin For ROI, RNI and Second Messengers: A Defect at Tuftsin Receptor Expression. The 9th International Congress of Immunology, San Francisco, CA 1995

38. Khare S, Rao DN, Modulation of Leprosy Derived Macrophages by Tuftsin for Respiratory Intermediates (ROI and RNI) and Second Messengers. 3rd IUBMB Conference, Singapore 1995

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39. Khare S, Bhutani Lk, Rao DN, Intacellular survival strategies of Mycobacterium leprae in Lepromatous Leprosy Patients Towards Tuftsin Stimulation. XXI Annual Conference of Association of Clinical Biochemists of India, Bangalore 1995

40. Khare S, Rao, DN. Modulation of Macrophages from Leprosy patients by Tuftsin for Respiratory Intermediates (ROI and RNI) and Second Messengers. XXI Annual Conference of Association of Clinical Biochemists of India, Banglore 1995. This paper was selected for PS Murthy oral Award Presentation.

41. Khare S, Bhutani LK, Rao, DN. Relationship Between Extracellular Stimulation of Oxygen Dependent Killing and Second Messengers Levels of Monocytes/Macrophages of Leprosy Patients. Presented at VII International Congress of Dermatology, New Delhi; India. 1994

42. Khare S, Bhutani LK, Rao, DN. Differential Stimulation of Monocytes /Macrophages Derived from Leprosy Patients: Molecular Basis for Defective Macrophage Functions of Tuftsin. XX Annual conference Association of Clinical Biochemists of India, Sevagram 1994

43. Khare S, Bhutani LK, Rao, DN. Depression of Tuftsin Mediated Respiratory Burst Capacity of Monocytes/Macrophages of Lepromatous Leprosy Patients. Alteration in signal transduction. Presented in IUIS-AIIMS advanced Immunology Course. New Delhi; India 1993

44. Khare S, Bhutani LK, Rao, DN. Defective Functional Activation of Macrophages: Correlation with the Membrane Potential Changes. XIX Annual Conference of Association of Clinical Biochemists, Hyderabad. 1993

45. Khare S, Bhutani LK, Rao, DN. Altered intracellular signaling during macrophages activation accounts for the defective immunogenic functions in leprosy patients. XX Indian Immunology Society. Bangalore. 1993. This paper was selected for the presentation in the mini symposium on infectious diseases.

46. Khare S, Iyer RR, Rao DN. Modulation of peripheral blood derived monocytes/macrophages for immunogenic functions in vitro by tuftsin in leprosy patients. XVI Annual Conference of Indian association of Medical Microbiologists. New Delhi. India1991. This paper received the award of Junior Best Paper presented in the Conference.

47. Khare S, Rao, DN. Reactive oxygen intermediates during macrophages activation with tuftsin derived peripheral blood of leprosy patients. XVIII Indian Immunology Society, Lucknow, India 1992

48. Khare S, Rao, DN. Modulation of peripheral blood drived monocytes/macrophages from leprosy patients for respiratory brust mechanism and maturation profile. XVIII Annual Conference of Associatin of Clinical Biochemists of India, New Delhi, India 1992. This paper was awarded the best paper presented in the Conference.

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49. Khare S, Bhutani LK, Rao, DN. Modulation of human lepromatous monocytes/macrophages function for reactive oxygen intermediates production and maturation profile. XVII Indian Immunology Society, New Delhi, India.1991

50. Kaur J. Khare S, and RAO, DN. Development of enzyme immunoassay for measuring serum tuftsin levels in normal and leprosy individuals. XVII Association of Clinical Biochemists of India, Shimla, India 1991

51. Khare S, Aggarawal A, Kalra SM, Sharma A, Singh PK. T-cell subsetting using monoclonal antibodies in patients of pulmonary tuberculosis. Presented in UP State Chapter Annual Conference and CME programme, Indian accociation of Pathologists and Microbiologists, Aligarh, India 1989

52. Khare S, Aggarawal A, Kalra SM, Sharma A, and Narang RK. Effect of industrial pollution on the development of pulmonary tuberculosis with special reference to immunological status. National Seminar on natural resource conservation and environmental management, Kanpur, India 1989

LOCAL SERVICE ACTIVITIES: Selection committee (Ad-hoc member) 2011 Faculty recruitment in Department of Gastroenterology and

Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR

2013 Faculty recruitment in Department of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR

Cultural diversity activities 2013 Actively participated in NCTR Cultural Diversity Festival 2010 Actively participated in Multicultural Event-Worldfest Served as a judge in the following Competitions: March 2012 Science Fair Judge for High School Students (State level)-Conway, AR March 2012 Science Fair Judge for High School Students (Regional level)-Little

Rock, AR February 2012 Science Fair Judge for High School Students, Little Rock, AR March 2011 Science Fair Judge for High School Students (State level)-Conway, AR February 2011 Science Fair Judge for High School Students (School level)-Little Rock,

AR April 2009 Texas Junior Academy of Science March 2009 Student Research Week at Texas A&M University January 2009 Texas Junior Science and Humanities Symposium April 2008 Texas Junior Academy of Science (High School students from Texas) March 2008 Student Research Week at Texas A&M University April 2007 Texas Junior Academy of Science (High School students from Texas) April 2006 Texas Junior Academy of Science (High School students from Texas)

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March 2006 Brazos Valley Regional Science and Engineering Fair for junior high and high school students

March 2005 Student Research Week at Texas A&M University, College Station, TX