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CURRICULUM VITAE Name: Anuja Ghorpade, Ph.D. Campus Address: Division of Research and Innovation EAD 858 3500 Camp Bowie Blvd Fort Worth, TX 76107 817-735-2055 (Main) Fax 817-735-0254 E-mail: [email protected] Note: Additions in blue are updates since July 1, 2016 while serving as the Interim VPR at UNTHSC.

Education:

1989-1994: Ph.D. - Doctor of Philosophy

National Institute of Immunology, New Delhi, India. Ph.D. Thesis: Molecular evaluation of expression of human growth hormone, a eukaryotic gene and heat-labile enterotoxin chain B, a prokaryotic gene in Escherichia coli and Vibrio cholerae

1987-1989: M.Sc. - Master of Science in Biotechnology Department of Biotechnology Maharaja Sayajirav University of Baroda, Gujarat, India. M. Sc. dissertation thesis: Studies on the effect of vanadium and molybdenum on the nitrogenase activity of cowpea Rhizobium

1984-1987: B.Sc.-Bachelor of Science in Microbiology (Physics, Chemistry) University of Bombay, Mumbai, India.

Academic Appointments and Experience: 1990-1992: Lecturer

National Institute of Immunology, New Delhi, India 5/94-7/97: Post-doctoral Research Associate

Department of Pathology and Microbiology University of Nebraska Medical Center, Omaha, NE

1997-1999 Instructor Department of Pathology and Microbiology

University of Nebraska Medical Center, Omaha, NE 1997-2007 Coordinator, Neural Cell Core Facility,

Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE

1997-2007 Chief Cellular Neurobiology and Neurovirology Program

Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE

1999- 2003 Assistant Professor Department of Pathology and Microbiology University of Nebraska Medical Center, Omaha, NE

Anuja Ghorpade, Ph.D. Curriculum Vitae

2000-2007 Scientific Director, Rapid Autopsy Program, Center for Neurovirology and Neurodegenerative Disorders,

University of Nebraska Medical Center, Omaha, NE 2000-2007 Graduate Faculty Member and Fellow

Department of Pathology and Microbiology College of Medicine

University of Nebraska Medical Center, Omaha, NE 2003-2004 Associate Professor

Department of Pathology and Microbiology University of Nebraska Medical Center, Omaha, NE

2004-2007 Associate Professor with Tenure Department of Pharmacology and Experimental Neuroscience University of Nebraska Medical Center

2004-2007 Courtesy Faculty Appointment Department of Biochemistry and Molecular Biology University of Nebraska Medical Center

2004-2006 Vice Chair for Research Department of Pharmacology and Experimental Neuroscience 2006-2007 Executive Vice Chair

Department of Pharmacology and Experimental Neuroscience 12/07-2009 Professor and Vice Chair Department of Cell Biology and Anatomy

University of North Texas Health Science Center 2010-2016 Professor and Chair Department of Cell Biology and Anatomy and renamed Cell Biology and Immunology after graduate school restructuring

University of North Texas Health Science Center 07/2016- Interim Vice President for Research University of North Texas Health Science Center Post-Degree Training and Continuing Education:

8/1996: Participant- “Creating and Operating Self-Managed Teams,” University of Nebraska-Lincoln College of Business Administration, August 6, 1996

10/2000: Participant- “Academic socialization and career management,” University of

Nebraska Medical Center, October 12-13, 2000 12/2000: Participant- “Problem-based learning”, Training for facilitators,

University of Nebraska Medical Center, December 8, 2000

5/2001: Participant- “Writing Instructional Objectives and Multiple Choice Questions," University of Nebraska Medical Center, May 2001, 2005

7/2005: Selected participant- Mid-Career Women Faculty Professional Development

Seminar organized by Association of American Medical Colleges Lansdowne, Virginia; July 9-12, 2005

10/2006: Participant- “Writing Objectives” – Principles of writing learning objectives,

University of Nebraska Medical Center, October 26, 2006


5/2007: Participant- “Productivity in the Midst of Chaos: Organizing Your Work and Time”, University of Nebraska Medical Center, May 8, 2007

2/2008: Invited participant- Leadership Assessment Retreat, University of North Texas

Health Science Center, February 22, 2007 6/2008: Invited participant- Leadership Development Institute, “Building Productive

Relationships”, University of North Texas Health Science Center, June 27, 2008 7/2009: Invited participant- Leadership Development Institute, “The Power of

Persuasion”, University of North Texas Health Science Center, July 25, 2009 10/2009: Invited participant- Leadership Development Institute, “Crucial Conversations”

University of North Texas Health Science Center, October 23, 2009 7/2010: Invited participant- Leadership Development Institute, “Performance

Management Training Workshop” University of North Texas Health Science Center, July 30, 2010

9/2010: Invited participant- Leadership Development Institute, “Developing a Culture of

Integrity” University of North Texas Health Science Center, September 17, 2010 Certificates and Licenses: None Grant/Contract Support: Title: “Targeting latent HIV Astroglial Reservoirs without Reactivation” Agency: NIH/NIMH 1 R21 MH113452-01 Dates: 05/01/17-03/31/19 Role: PI Title: “Neuronal Survival, HIV-1 and Astrocyte-TIMP-1” Agency: NIH/NINDS 1R01 NS048837-06 Dates: 2/01/04-4/30/19 Role: PI Title: “Astrocyte-TAAR1 and METH in HAND” Agency: NIH/NIDA 1R01 DA039789-01 Dates: 7/15/15-6/30/20 Role: PI Title: “Health Disparities and CD40L: Novel Biomarkers for HIV disease progression” Project 2: Texas Center for Minority Health, Education, Research, and Outreach Agency: NCMHD P20 1 71046 Dates: 7/01/12–6/30/18 Role: Research Core Project 2 PI, Ghorpade, A. Completed awards: Title: “Stroke Therapy” Agency: NIH/NINDS 1 R01 NS070896-01

Anuja Ghorpade, Ph.D. Curriculum Vitae Dates: 8/15/10–7/30/15 Effort: 5% Role: Co-I, Ghorpade, A. Title: “CXCL8-mediated glial cross-talk and neuroprotection in HIV-1 Dementia” Agency: NIMH R01 MH087345-01 Dates: 08/01/09-07/31/15 Effort: 20% Role: PI Title: “Mechanisms and interventions for methamphetamine and HIV-1 induced CNS injury” Agency: DHHS/NIH1 R01 DA025566-01A1 Dates: 04/01/09-3/31/15 Effort: 10% Role: Multi-PI Title: “METH/HIV-1 Regulation of Astrocyte Responses: TAAR1 and Hyperthermia Agency: NIDA 1F31DA037832-01 (to Irma Lisa Cisneros) Dates: 4/01/14-3/31/2015 Role: Mentor Title: “Regulation of Astrocyte TIMP-1 in HIV-Associated Dementia” Agency: NIH/NINDS 1F31NS0720006-01A1 (to JA Fields) Dates: 3/15/11– 3/14/13 Role: Mentor Title: “Astrocyte activation, Fas ligand, and HIV-1 dementia” Agency: NIH/NINDS NS43113 Dates: 4/1/02-3/31/06 Role: PI Title: “Cells and Tissue Core” Core A Program Project: “Neural immunity in HIV dementia” Agency: NIH PO1 NS35432 Dates: 05/01/03-04/30/08 Role: Core A PI Title: “Rapid Autopsy Program” Agency: UNMC Dates: 5/00-6/08 Role: PI Title: “Effect of alcohol on HIV-1 immune responses and BBB damage” Agency: NIH/NIAAA R01 AA13846 Dates: 12/01/02-8/01/06 Role: Co-I Title: “Training Program in Neurovirology” Agency: NIMH Dates: 7/1/02-6/30/07 Role: Co-I Title: “Molecular Mechanisms of HIV-1 Associated Encephalopathy” Agency: NIH

Anuja Ghorpade, Ph.D. Curriculum Vitae Dates: 05/01/03-04/30/08 Role: Co-I Project 3 Title: "Macrophages, Neuronal K+ Channels and HIV-1 Dementia” Agency: NIH/NAED R01 NS41862 competitive renewal Dates: 04/01/05-03/31/10 Role: Co-I Title: “PPAR-gamma-mediated neuroprotection against HIV-1 and alcohol CNS injury” Agency: NIH/NIAAA RO1 AA015913-01A Dates: 9/30/05-6/30/10 Role: Co-I Title: “Tat-Peptide conjugated nanoparticles for CNS delivery” Agency: NIH R21MH067525-01A2 Dates: 12/01/03-11/30/05 Role: Co-I Title: “Matrix Metalloproteinases in HIV-1 Encephalopathy” Agency: Elizabeth Glaser Pediatric AIDS Foundation Dates: 02/01/00-01/31/01 Role: PI Title: “UNMC Bridge Funding Award” Agency: College of Medicine, UNMC Dates: 2/28/00-2/28/01 Role: PI Title: "Linkages between HIV-1 Associated Dementia and Alzheimer's Disease" Agency: University of Nebraska Medical Center Dates: 07/01/99-06/30/00 Role: PI Title: "A Cellular Model for HIV-1 Neurovirulence" Agency: Elizabeth Glaser Pediatric AIDS Foundation Dates: 1/98-12/00 Role: PI Title: “Neuronal Physiology and HIV-1 Associated Dementia” NINDS RO1 NS41862 Dates: 6/01/01-5/31/05 Role: Co-I Pending: None Patents: None Other appointments or positions not given above 2009-12: Elected Member, University of North Texas Health Science Center Graduate Council 2014: Academic Editor, PlosONE

Anuja Ghorpade, Ph.D. Curriculum Vitae Consulting Positions (academic, government, and industry; also include editorial duties):

Ad hoc Journal reviews: Journal of Leukocyte Biology Journal of Neurovirology Journal of Neuroimmunology Journal of Neuroinflammation Journal of Neuroimmune Pharmacology AIDS Research and Human Retroviruses GLIA Journal of Neuroscience Journal of Neurochemistry Journal of Neuroscience Research Journal of Biological Chemistry Journal of Immunology

Military Service: None Honors and Awards: Recipient of junior research scholar award, National Institute of Immunology, New Delhi, India, 1989.

Recipient of senior research scholar award, National Institute of Immunology, New Delhi, India, 1990.

Recognition for highest GPA in the pre-Ph.D. courses, National Institute of Immunology, New Delhi, India, 1990.

Recipient of the “Best Research Leading to a Product” award for 1989-90, National Institute of Immunology, India. Vada Kinman Oldfield Research Scholar in Alzheimer’s Disease Research, 2002.

Selected mentor for young investigators “Meet the Mentors” session, Society for Neuroimmune Pharmacology, Santa Fe, New Mexico, April 2005.

Core participant, National Science Foundation-Integrative Graduate Education and Research Traineeship Program (IGERT) – Joint Program Proposal by Iowa State University/UNMC, September 2006.

Invited chair for the session “Pathology and Therapy of Neurodegenerative Disorders”, 4th International Nanomedicine and Drug Delivery Symposium. Omaha, NE, October, 2006. 2007 College of Medicine Joseph P. Gilmore Outstanding Investigator Award recipient, University of Nebraska Medical Center, March 2007.

2010 Fort Worth Business Press, HealthCare Hero, February 2010.

2011 President’s Award for Research Excellence, UNTHSC. January 19th, 2012.

2011 Benjamin L Cohen Award for outstanding Research Achievement, 2011.

2011-12 Graduate Student Association, Outstanding Graduate Faculty Award, 2012.

2012 The Society on Neuroimmune Pharmacology Distinguished Service Award, for Extraordinary Services to the SNIP and to the Accomplishment of its Mission, April 2012.

Anuja Ghorpade, Ph.D. Curriculum Vitae 2015- Member - Leadership 125 team at UNTHSC

2016- Graduate - HSC Fellows-Upper Level Leadership Development Program - Cohort 1

Membership and Offices in Professional Societies and Scientific Centers:

1999- : Society for Neuroscience 2000- : International Society for Neuroimmunology 2000- : International Society for Neurovirology 2000- : American Association for the Advancement of Science

2001- : American Society for Microbiology 2003- : Member, Nebraska Center for Virology

2003- : Society for NeuroImmune Pharmacology 2007-08: Young Investigators Travel Award chair (2007 and 2008), 2010-13: Membership Chair, Society on Neuroimmune Pharmacology 2011- : Patron Member, Society on Neuroimmune Pharmacology 2013-14: Elected Treasurer, Society on Neuroimmune Pharmacology 2014-15: Finance committee member, Society on Neuroimmune Pharmacology

Committee Assignments:

1987-89: Coordinator, Biotechnology Society, M.S. University, Baroda, India 1992: Resource person for workshop “Bioprocess development of recombinant

products-principles and practices” National Institute of Immunology, India 2000-07: Chair, Executive Committee, UNMC, Rapid Autopsy Program 2001-07: Member, UNMC Acute Bereavement Services 2003: Member, Neuroscience Research Training Program Steering Committee 2004-05: Search committee for new faculty member, UNMC, Department of

Biochemistry, UNMC 2004: Executive Committee, UNMC, Department of Pharmacology 2005-06: Chair, Search committee for a joint faculty in the Redox Center and Department

of Pharmacology and Experimental Neuroscience 2005- : Member, Society for Neuroimmune Pharmacology, Young Investigators travel

award committee 2005-07: Member, Advanced Neuroimmunology (PEN 950) Course supervisory

committee 2006-07: Member, UNMC Sponsored Programs Administration Grants.gov - Vendor

Solution – Selected member for PI advisory group 2006-07: Chair, Search committee for a faculty recruit in the Department of

Pharmacology and Experimental Neuroscience 2006: Panel member, Internal Review for COBRE proposal, Center for Nanomedicine

and Drug Delivery 2006-07: Member, Search committee for a Pharmacology Educator in the Department of

Pharmacology and Experimental Neuroscience 2006-08: Chair, Society for Neuroimmune Pharmacology, Young Investigators travel

award committee 2007: Member, University of Nebraska Medical Center Search Committee for Dean of

the College of Pharmacy 2007: Invited participant, Chancellor’s Strategic Planning Retreat, University of

Nebraska Medical Center, April 12, 2007 2007-: Co-Director, Brain Bank, University of North Texas Health Science Center


2008-2010: Chair, University of North Texas Health Science Center Search Committee for CBAN Faculty

2008-: Member, University of North Texas Health Science Center Institute for Aging and Alzheimer’s Disease Research Training Fellowship Committee

2008-2009: Member, University of North Texas Health Science Center GSBS CBAN Graduate Education Committee

2008: Member, University of North Texas Health Science Center Search Committee for Chair of Dept. of Integrative Physiology 2008-: Member, University of North Texas Health Science Center Research Integrity

Committee 2008: Member, University of North Texas Health Science Center Faculty Retention

and Rewards Committee 2008-11: Member, University of North Texas Health Science Center President’s

Research Thinking Council 2009: Member, University of North Texas Health Science Center President’s Strategic

Thinking Council 2010-: Member, University of North Texas Health Science Center GSBS Executive

Committee 2011-: Member, University of North Texas Health Science Center Basic Science Chair

Committee 2012-: Member, University of North Texas Health Science Center Leadership

Committee 2012-: Member, University of North Texas Health Science Center TCOM Curriculum

Modernization Committee 2012-: Chair, University of North Texas Health Science Center, Molecular Biology and

Immunology Chair Search Committee 2015-: Member, University of North Texas Health Science Center/TCU joint MD

School Dean Search Committee 2016-: President’s Cabinet, UNTHSC 2016-: Chair, Research Advisory Council, UNTHSC 2017-: Chair, President’s Research Council, UNTHSC

Grant reviews (Local): 2000-2002: University of Nebraska Medical Center, Seed Grant Review Committee 2005-2006: Edna Ittner Trust grant reviews, UNMC

2008: Member, NIMH Training Grant Fellowships 2008: Member, ForHER Seed Grant Program 2009: UNTHSC Seed Grant Program Grant reviews (National): 2003- : National Institute Health, Molecular Developmental and Cellular Neuroscience

2, Ad hoc reviewer, February 2003 2004- : National Institute of Health, NeuroAIDS & End-organ Diseases, Ad hoc: April 2004 March 2005 December 2005 November 2006 2003- : National Institute of Health, Neurodegeneration and Biology of Glia, Off-cycle

Ad hoc reviews for regular study section:


November 2003 December 2004 2006- : HIV/AIDS F31/F32 Fellowship Reviews-Electronic discussions Forum: November 2006 March 2007 2003-2007: Regular study section member, National Institute of Health, Neurodegeneration

and Biology of Glia (name changed to Neurodegeneration and Glial Biology in 2005)

2007-: NIMH Special Emphasis Panel 2008-: Training grant SEP 2008-: NINDS Special Emphasis Panel 2008: NIGMS Score Review special emphasis panel 2008: Chair, NIAAA Special Emphasis Panel 2009: Challenge grant reviews 2009: NIDA special emphasis panel 2009: Mail reviewer, Special Emphasis Panel, MDCN member conflicts 2009: Neuro-AIDS & End organ Diseases 3/2010: Ad hoc, Neuro-AIDS & End Organ Disease Panel 4/2010 AARR Member conflict Special Emphasis Panel 7/2010 Ad hoc, Neuro-AIDS & End Organ Disease Panel 11/2010 ZRG1 – AARR -J-53 12/2010 NAED Member Conflict Special Emphasis Panel 2011: Chair, Neuro-AIDS & End Organ Disease Special Emphasis Panel 4/2012: Chair, CSR Special Emphasis Panel, 2012/05 ZRG1-AARR-C-22 6/2012: NIAAA Special Emphasis Panel, Meeting 2012/08 ZAA1-DD-11 6/2012: NICHD Special Emphasis Panel, Meeting 2012/08 ZHD1-DRG-D-55 7/2012: CSR, Standing member, Special Emphasis Panel, R15 (AREA), Meeting 2012/10 ZRG1-MDCN-E-96 7/2012: Ad hoc, Neuro-AIDS and End-Organ Diseases 10/2012: MDCN, Special Emphasis Panel, Meeting 2013/01 ZRG1-MDCN-T-05 11/2012: Ad hoc, CSR, Meeting 2013/01 ZRG1-AARR-D-58 11/2012: Ad hoc, Neuro-AIDS and End-Organ Diseases 12/2012: NIMH, Special emphasis panel, Eradication of HIV-1 from CNS Reservoirs:

Implications for therapeutics), Meeting 2013/01 ZMH1-ERB-M-03 06/2013: CSR, R15, Standing member, Special Emphasis Panel, R15 (AREA) 07/2013: Member and alternate chair, Neuro-AIDS and End-Organ Diseases (NIH)

Community Services:

1995: Mentor, workshop on calligraphy Art Therapy program for delinquent children

Youth Rehabilitation Institute of Nebraska, Kearney, NE 1996: Mentor, HIV-AIDS Internship Program

Laboratory of Viral Pathogenesis UNMC, Omaha, NE 1997: Participant, Diversity Training and Science Fair, Keystone, NE

2004-2007 Member, Education Committee, Hindu Temple of Nebraska, Omaha, NE 2004-2007 Member, Kuchipudi Dance Academy, Omaha, NE 2004-2007 Teacher, Bal Vihar Hindu Temple-Dwitiya, Sunday School for teaching children

grades 3 and 4 about Indian Culture and Hindu values.


2003-2008 Member, Medical Scientific Panel, Alzheimer’s Association, Omaha and Eastern Nebraska Chapter, Also serving Southwestern Iowa and Northeast Nebraska.

2009: Featured speaker in the series “Biomedical Sciences as a career for women”, Girl scouts, Aledo, TX

2013: Chaperon, The Timber Creek High School Varsity Marching Band Bibliography: Articles published in scholarly journals 1. Ghorpade, A. and Garg, L. C. Efficient processing and export of human growth hormone by

heat labile enterotoxin chain B signal sequence. FEBS Letters. 1993;330:61-65. 2. Panda, A. K., Ghorpade, A., Mukhopadyay, A., Talwar, G. P. and Garg, L. C. High cell density

fermentation of recombinant Vibrio cholerae for the production of B subunit of Escherichia coli enterotoxin. Biotechnol Bioengineering. 1995;45(3):245.

3. Ghorpade, A. and Garg, L. C. Efficient expression, processing and secretion of a biologically

active mammalian protein by Vibrio cholerae. FEBS Letters. 1996;387:167-70. 4. Bukrinskaya, A. G., Ghorpade, A., Heinzinger, N. K., Smithgall, T. E., Lewis, R. E., and

Stevenson, M. Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA. Proc Natl Acad Sci USA. 1996;93:367-71.

5. Ghorpade, A. and Baxter, T. Biochemistry and molecular regulation of matrix macromolecules

in abdominal aortic aneurysms. In: The Abdominal Aortic Aneurysm: Genetics, Pathophysiology, and Molecular Biology. Ann of New York Acad of Sci. 1996;800:138-150.

6. Gendelman, H. E., Persidsky, Y., Ghorpade, A., Limoges, J., Stins, M., Fiala, M. and Morrisett,

R. The neuropathogenesis of the AIDS dementia complex. AIDS. 1997;11(Suppl A): S35-S45. 7. Ghorpade, A., Nukuna, A., Che, M., Persidsky, Y., Carter, E., Carhart, L. and Gendelman, H. E.

Human immunodeficiency virus neurotropism: an analysis of viral replication and cytopathicity for divergent strains in monocytes and microglia. J Virol, 1998;72:3340-3350.

8. Ghorpade, A., Persidsky, Y., Nukuna, A., Bock, P., Che, M., Carter, E., Carhart, L., Gendelman,

H. E. and Mackay, C. Role of the b-chemokine receptors CCR3 and CCR5 in human immunodeficiency virus type 1 infection of monocytes and microglia. J Virol. 1998;72:3351-3361.

9. Gendelman, H. E., Zheng, J., Coulter, C. L., Ghorpade, A., Che, M., Thylin, M., Rubocki, R.,

Persidsky, Y., Hanh, F., Reinhard, J. and Swindells, S. Suppression of inflammatory neurotoxins by highly active antiretroviral therapy in human immunodeficiency virus-associated dementia. J Inf Dis. 1998;178:1001-1008.

10. Davis, V., Persidskaia, R., Baca-Regen, L., Persidsky, Y., Ghorpade, A., Itoh, Y., Negase, H.

and Baxter, T. Matrix metalloproteinase-2 production and its binding to the matrix are increased in abdominal aortic aneurysms. Atherosclero. Thromb. Vasc. Biol. 1998;18:1625-1633.

11. Zheng, J., Thylin, M.R., Ghorpade, A., Xiong, H., Cotter, R., Niemann, D., Che, M., Zeng, Y-C.

Shepard, R.B., Shwartz, J.M., Persidsky, Y. and Gendelman, H.E. Intracellular CXCR4


signaling, neuronal apoptosis, and the neuropathogenic mechanisms for HIV-1 associated dementia. J. Neuroimmunol. 1999;98:185-200.

12. Zheng, J, Ghorpade, A., Thylin M. R., Cotter, R., Niemann, D., Epstein, L., Swartz, J. M.,

Shepard, R. B., Liu, X. J., Nukuna, A. and Gendelman, H. E. Lymphotropic virions affect chemokine receptor-mediated neuronal apoptosis: Implications for HIV-1 associated dementia. J. Virol. 1999;73(10):8256-8267.

13. Persidsky, Y., Ghorpade, A., Rasmussen, J., Limoges, J., Liu, S.J., Stins, M., Fiala, M., Way,

D., Kim, K. S., Witte, M.H. Weinand, M., Carhart, L. and Gendelman, H.E. Microglial and Astrocyte Chemokines Regulate Monocyte Migration Through the Blood-Brain Barrier in HIV-1 Encephalitis. Am. J. Path. 1999;155(5):1599-1611.

14. Verma, S., Ghorpade, A., Tiwari, G., Das, P. and Garg, L. C. cDNA cloning and sequence

analysis of Bubaline growth hormone. DNA Sequence. 1999;10(2):101-103. 15. Ghorpade, A., Persidskaia, R., Suryadevara, R., Che, M., Persidsky, Y. and Gendelman, H. E.

Mononuclear phagocyte Differentiation, Activation and Viral Infection effect the Secretion of Matrix Metalloproteinases: Implications for HIV-1-Associated Dementia. J. Virol. 2001;75(14):6572-83. PMCID: PMC114381 An artistic representation of this work (modified figure) was selected for the cover of the journal.

16. Zheng, J., Thylin, M. R., Cotter, R. L., Lopez, A. L., Ghorpade, A., Persidsky, Y., Xiong, H.,

Leisman, G. B., Che, M. and Gendelman, H. E. HIV-1 infected and immune competent mononuclear phagocytes induce quantitative alterations in neuronal dendritic arbor: relevance for HIV-1-associated dementia. Neuro. Res. 2001;3(5):443-459.

17. Zheng, J., Thylin, M. R., Persidsky, Y., Williams, C. E., Cotter, R. L., Zink, W., Ryan, L.,

Ghorpade, A., Lewis, K. and Gendelman, H. E. HIV-1 infected immune competent mononuclear phagocytes influence the pathways to neuronal demise. Neuro. Res. 2001;3(5):461-484.

18. Canki, M., Thai, J. N. F., Chao, W., Ghorpade, A., Potash, M. J., and Volsky, D. J. Highly

productive infection with pseudotyped human immunodeficiency virus type-1 (HIV-1) indicates no intracellular restrictions to HIV-1 replication in primary human astrocytes. J Virol. 2001,75(17):7925-33. PMCID: PMC115036

19. Xiong, H., Boyle, J., Winkelbauer, M., Gorantla, S., Zheng, J., Ghorpade, A., Persidsky Y,

Carlson KA, Gendelman HE. Inhibition of long-term potentiation by interleukin-8: Implications for human immunodeficiency virus-1-associated dementia. J Neurosci Res 2003 Feb 15;71(4):600-607.

20. Ikezu, T., Luo, X., Weber, G. A., Zhao, J., McCabe, L., Buescher, J. L., Ghorpade, A., Zheng,

J., and Xiong, H. Amyloid Precursor Protein-Processing Products Affect Mononuclear Phagocyte Activation: Pathways for sAPP and Aβ Mediated Neurotoxicity. J. Neurochem. 2003 May;85(4):925-34.

21. Suryadevara, R., Holter, S., Borgmann, K., Persidsky, R., Labenz, C., Persidsky, Y.,

Gendelman, H.E., Wu, L., Ghorpade, A. Regulation of Tissue Inhibitor of metalloproteinase-1 by Astrocytes: Links to HIV-1 dementia. 2003 GLIA 44(1):47-56.

Anuja Ghorpade, Ph.D. Curriculum Vitae 22. Ghorpade, A., Holter, S., Borgmann, K., Persidsky, R., and Wu, L. HIV-1 and IL-1β regulate Fas

Ligand expression in human astrocytes through the NFκB pathway. 2003 J. Neuroimmunol. Aug;141(1-2):141-9.

23. Wang, Z., Pekarskaya, O., Bencheikh, M., Chao, W., Gelbard, H.A., Ghorpade, A., Rothstein,

J.D., Volsky, D.J. Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120. 2003 Virology Jul;20:312(1):60-73.

24. Erichsen, D., Lopez, A.L., Peng, H., Niemann, D., Williams, C., Bauer, M., Morgello, S., Cotter,

R., Ryan, L.A., Ghorpade, A., Gendelman, H.E., Zheng, J. Neuronal injury regulates fractalkine: relevance for HIV-1 associated dementia. 2003 J. Neuroimmunol. May; 138(1-2):144-55.

25. Gardner, J. and Ghorpade, A. Tissue Inhibitor of metalloproteinase-1: The TIMPed balance of

matrix metalloproteinases in the central nervous system. 2003 J Neurosci Res. Dec 15 74;(6):801-806.

26. Suryadevara, R., Holter, S., Borgmann, K., Persidsky, R., Labenz, C., Persidsky, Y.,

Gendelman, H.E., Wu, L., Ghorpade, A. Tissue Inhibitor of metalloproteinase-1 and activated astrocytes: Links to HIV-1 dementia. 2003 GLIA 44(1):47-56.

27. Nukuna, A., Gendelman, H.E., Limoges, J., Rasmussen, J., Poluektova, L., Ghorpade, A.,

Persidsky, Y. Levels of human immunodeficiency virus type 1 (HIV-1) replication in macrophages determines the severity of murine HIV-1 encephalitis. 2004 J. Neurovirol., 10:82-90.

28. Haorah, J., Heilman, D., Diekmann, C., Osna, N., Donohue, T., Ghorpade, A., Persidsky, Y.

Alcohol and HIV decrease proteasome and immunoproteasome function in macrophages: Implications for impaired immune function during disease. 2004 Cellular Immunol., 229:139-48.

29. Ghorpade, A., Bruch, L., Persidsky, Y., Chin, B., Brown, WHC, Borgmann, K., Persidsky, R.,

Wu, L., Holter, S., Cotter, R., Faraci, J., Heilman, D., Meyer, V., Potter, J., Swindells, S., Gendelman, HE. Development of a Rapid Autopsy Program for Studies of Brain Immunity. 2005 J. Neuroimmunol. 163:(1-2):135-144.

30. Ghorpade, A., Persidsky, Y., Swindells, S. Borgmann, K., Persidsky, R., Holter, S., Cotter, R.,

Gendelman, H.E., Investigations of neuroinflammatory responses from microglia recovered from HIV-1-infected and seronegative subjects. 2005 J. Neuroimmunol. 163:145-156.

33. Deshpande, M., Zheng, J., Borgmann, K., Persidsky, R., Schellpeper, C., Wu, L. and Ghorpade,

A. Role of Fas ligand in astrocyte-mediated neuronal damage: Potential links to HIV-1 Dementia. 2005 Neurotoxicity Research, 7(3):183-192.

34. Haorah, J., Heilman, D., Knipe, B., Chrastil, J., Leibhart, J., Ghorpade, A., Miller, D., Persidsky,

Y. Ethanol-Induced Activation of Myosin Light Chain Kinase Leads to Dysfunction of Tight Junctions and Blood-Brain Barrier Compromise 2005 Alcoholism Clinical and Experimental Research, Jun;29 (6):999-1009.

Anuja Ghorpade, Ph.D. Curriculum Vitae 35. Haorah, J., Knipe, B., Leibhart, J., Ghorpade, A. and Persidsky, Y. Alcohol-induced oxidative

stress in brain endothelial cells causes blood-brain barrier dysfunction. 2005 J. Leukocyte Biol. Dec;78(6):1223-32.

36. Dhar A, Wu L and Ghorpade A. A novel role of TGF-β in differential astrocyte-TIMP-1 regulation

in HIV-1 dementia. J Neurosci. Res. 2006 May 15;83(7):1271-80. 37. Gardner J, Borgmann K, Deshpande M, Dhar A, Wu L, Persidsky R and Ghorpade A. Potential

mechanisms for astrocyte-TIMP-1 downregulation in chronic inflammatory diseases. J Neurosci. Res. 2006 May 15;83(7):1281-92. An artistic representation of this work (modified figure) was selected for the cover of the journal.

38. Potula, R., Haorah, J., Knipe, B., Leibhart, J., Chrastil, J., Heilman, D., Dou, H., Reddy, R.,

Ghorpade, A. and Persidsky, Y. Alcohol abuse enhances neuroinflammation and impairs immune responses in an animal model of HIV-1 encephalitis (HIVE). Am J Pathol. 2006 Apr;168(4):1335-44. PMCID: PMC1606563

39. Peng, H., Whitney, N., Erdmann, N., Ghorpade, A. and Zheng, J. HIV-1-infected and/or immune

activated macrophages regulate astrocyte SDF-1 production through IL-1β. GLIA 2006 Nov;1:54(6):619-29. PMCID: PMC1919406

40. Vitivosky, V., Thomas, M., Ghorpade, A. Gendelman, H.E. and Banerjee, R. A Functional

Transsulfuration Pathway in Brain Regulates Glutathione Homeostasis. J. Biol Chem. 2006 Nov;24:281(47):35785-93. Epub 2006 Sep 27.

41. Banerjee, S., Walseth, T. F., Borgmann, K., Wu, L., Bidasee, K. R., Kannan, M. S and

Ghorpade. A. CD38/cyclic ADP-ribose regulates astrocyte calcium signaling: Implications for neuroinflammation and HIV-1-associated dementia. J Neuroimmune Pharmacol 2008 Sep;3(3):154-64. Epub 2008 Jun 26.

42. Reddy, M. K., Wu, L., Kou, W., Ghorpade, A., Labhasetwar, V. Superoxide dismutase-loaded

PLGA nanoparticles protect cultured human neurons under oxidative stress. Applied Biochem & Biotechnol. 2008 Dec;151(2-3):565-77. Epub 2008 May 29. PMCID: PMC2670226

43. Kou, W., Deshpande, M.S., Banerjee, S., Dhar, A., Eudy, J., Smith, L.M., Persidsky, R., Borgmann, K., Wu, L., Sakhuja, N., Ghorpade, A. Genomic analysis if IL-1β-activated astrocyte inflammatory profiles: CD38 regulation and relevance to HIV-1 encephalitis. J Neurosci Res. 2009 Apr 13; 87(10):2326-2339.

44. Rao, K. S., Ghorpade, A., Labhasetwar, V. Targeting anti-HIV drugs to the CNS. Expert Opin. Drug Deliv. 2009 6(8): 1-14. PMCID: PMC2754315

45. Chao, C., and Ghorpade, A. Production and roles of glial tissue inhibitor of metalloproteinase-1

in Human Immunodeficiency Virus-1-associated dementia neuroinflammation: A review. Am J Infect Dis. 2009: 5(4): 314-320. PMCID: PMC2888306

46. Jing, T., Wu, L., Borgmann, K., Surendran, S., Ghorpade, A., Liu, J., and Xiong, H. Soluble

factors from IL-1b stimulated astrocytes activate NR1a/NR2B receptors: Implications for HIV-1-induced neurodegeneration. Biochem Biophys Res Commun, 2010 Nov 12;402(2):241-6. PCMID: PMC2981639

Anuja Ghorpade, Ph.D. Curriculum Vitae 47. Xie, L., Poteet, E.C., Li, W., Scott, A.E., Liu, R., Wen, Y., Ghorpade, A., Simpkins, J.W., Yang,

S.H. Modulation of polymorphonuclear neutrophil functions by astrocytes. J Neuroinflammation. 2010 Sep 9;7:53. PMCID: PMC2942816

48. Ghorpade A. Reprogrammed astrocytes with old ‘memories’ blossom into region-specific

neurons. Protein Cell. 2011 Feb; 2(2):87-9. PMID: 21400043 49. Fields J, Gardner-Mercer J, Borgmann K, Clark I, Ghorpade A. CCAAT/Enhancer-Binding

Protein-β (C/EBPβ) Regulates Astrocyte Tissue Inhibitor of Metalloprotease-1 (TIMP) Expression during HIV-1 Infection. J Neurochem. 2011 Jul;118(1):93-104. PMID: 21281310 PMCID: PMC3112278 An artistic representation of this work (modified figure) was selected for the cover of the journal.

50. Borgmann K, Rao KS, Labhasetwar V, and Ghorpade A. Efficacy of Tat-conjugated ritonavir-

loaded nanoparticles in reducing HIV-1 replication in monocyte-derived macrophages and cytocompatibility with macrophages and human neurons. AIDS Research and Human Retroviruses. 2011 Aug;27(8):853-62. PCMID: PMC3149452

51. Ashutosh, Kou W, Cotter R, Borgmann K, Wu L, Persidsky R, Sakhuja N, Ghorpade A. CXCL8

protects human neurons from amyloid-β-induced neurotoxicity: Relevance to Alzheimer's disease. Biochem Biophys Res Commun. 2011 Sep 9;412(4):565-71. Epub 2011 Aug 5. PCMID: PMC3236067

52. Mamik MK, Banerjee S, Walseth TF, Hirte R, Tang L, Borgmann K, Ghorpade A. HIV-1 and IL-

1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms. J Neuroinflammation. 2011 Oct 25;8:145. PMID:22027397, PMCID: PMC3247131.

53. Cisneros I. and Ghorpade A. 2012, HIV-1, Methamphetamine and Astrocytes Glutamate

regulation: Combined excitotoxic implications for Neuro-AIDS, Current HIV Research. 2012. Curr HIV Res. 2012 May 11. PMID: 22591363. PMCID: PMC3580828

54. Ashutosh, Chao C, Borgmann K, Brew K and Ghorpade A. Tissue inhibitor of

metalloproteinases-1 protects human neurons from staurosporine and HIV-1-induced apoptosis: Mechanisms and relevance to HIV-1-associated dementia. Cell death and differentiation Cell Death Dis. 2012 Jun 28;3:e332. doi: 10.1038/cddis.2012.54. PMID: 22739984 PMCID: PMC3388228

55. Fields J, and Ghorpade A.. C/EBPβ regulates multiple IL-1β-induced human astrocyte

inflammatory genes. J Neuroinflammation. J Neuroinflammation. 2012 Jul 20;9(1):177. PMID: 22818222 PMCID: PMC3464795

56. Vartak-Sharma N. and Ghorpade A. Astrocyte elevated gene-1 regulates astrocyte responses

to neural injury: Implications for reactive astrogliosis and neurodegeneration. J Neuroinflammation. J Neuroinflammation. 2012 Aug 11;9(1):195. PCMID: PMC3488579

57. Mamik MK and Ghorpade A. Src Homology-2 Domain-Containing Protein Tyrosine

Phosphatase (SHP)2 and p38 Regulate the Expression of Chemokine CXCL8 in human


astrocytes. PLoS One. 2012; 7(9): e45596. Published online 2012 September 21. doi: 10.1371/journal.pone.0045596PMCID: PMC3448633.

58. Fields J, Cisneros IE, Borgmann K, Ghorpade A. Extracellular regulated kinase 1/2 signaling is

a critical regulator of interleukin-1β-mediated astrocyte tissue inhibitor of metalloproteinase-1 expression. PLoS One. 2013; 8(2): e56891. Published online 2013 February 14.doi:10.1371/journal.pone.0056891 PMCID: PMC3572966.

59. Poteet E, Choudhury GR, Winters A, Li W, Ryou MG, Liu R, Tang L, Ghorpade A, Wen Y, Yuan

F, Keir ST, Yan H, Bigner DD, Simpkins JW, Yang SH. Reversing the Warburg effect as a treatment for glioblastoma. J Biol Chem. 2013 Mar 29;288(13):9153-64. doi: 10.1074/jbc.M112.440354. PCMID: PMC3610988

60. Singhal, A., Morris, V. B., Labhasetwar, V. and Ghorpade, A. Nanoparticle-mediated catalase

delivery protects human neurons from oxidative stress. Cell Death Dis. 2013. Nov 7;4: e903. doi: 10.1038/cddis.2013.362. PCMID: PMC3847304

61. Mamik, M. K., and Ghorpade, A. Chemokine CXCL8 promotes HIV-1 replication in human

monocyte-derived macrophages and primary microglia via NF-κB translocation. PLoS One. 2014 Mar 24;9(3):e92145. doi: 10.1371/journal.pone.0092145. PMCID: PMC3963875

62. Vartak-Sharma N, Gelman BB, Joshi C, Borgmann K, Ghorpade A. Astrocyte Elevated Gene-1

is a Novel Modulator of HIV-1-Associated Neuroinflammation via Regulation of Nuclear Factor-κB Signaling and Excitatory Amino Acid Transporter-2 Repression. J Biol Chem. 2014 May 22. pii: jbc.M114.567644. PCMID: PMC4094071

63. Cisneros, I. E., and Ghorpade, A. Methamphetamine and HIV-1-induced neurotoxicity: Role of

trace amine associated receptor 1 cAMP signaling in astrocytes. Neuropharmacology, 2014 Oct;85:499-507. DOI: 10.1016/j.neuropharm.2014.06.01 PMID: 24950453

64. Pandey, R. and Ghorpade, A. Cytosolic phospholipase A2 regulates alcohol-mediated astrocyte

inflammatory responses in HIV-associated neurocognitive disorders. Cell Death Discov 2015; 1: 15045

65. Pandey, R. and Ghorpade, A. HIV-1 and alcohol abuse promote astrocyte inflammation: A

mechanistic synergy via the cytosolic phospholipase A2 pathway. Cell Death Dis 2015 Dec 10;6:e2017. doi: 10.1038/cddis.2015.346 PMID: 26658191

66. Borgmann, K. B., and Ghorpade. A. HIV-1, methamphetamine and astrocytes at neuroinflammatory crossroads. Front Microbiol. 2015 Oct 27;6:1143. doi: 10.3389/fmicb.2015.01143. eCollection 2015. PMID: 26579077

67. Mamik, M. K. and Ghorpade, A. CXCL8 as a potential therapeutic target for HIV-associated

neurocognitive disorders. Curr Drug Targets. 2016;17(1):111-21. PMID: 26112047 68. Vartak-Sharma, N, Nooka, S and Ghorpade, A. Astrocyte Elevated Gene-1 (AEG-1) and the

A(E)Ging HIV/AIDS-HAND. Prog Neurobiol. 2016 Apr 14. pii: S0301-0082(15)30091-5. doi: 10.1016/j.pneurobio.2016.03.006. [Epub ahead of print]

Anuja Ghorpade, Ph.D. Curriculum Vitae 69. Joshi CR, Labhasetwar V, Ghorpade A. Destination Brain: the Past, Present, and Future of

Therapeutic Gene Delivery. J Neuroimmune Pharmacol. 2017 Mar;12(1):51-83. doi: 10.1007/s11481-016-9724-3. Epub 2017 Feb 3.

Articles accepted for publication: 70. Nooka S and Ghorpade A. HIV-1-associated inflammation and antiretroviral therapy regulate

astrocyte endoplasmic reticulum stress responses. Cell Death & Discovery, In press. 71. Nooka S and Ghorpade A. Organellar stress intersects the astrocyte endoplasmic reticulum,

mitochondria and nucleolus in HIV associated neurodegeneration. Cell Death & Disease. In press.

Articles in revision: 72. Borgmann K and Ghorpade A. Methamphetamine augments concurrent astrocyte

mitochondrial stress, oxidative burden and antioxidant capacity: tipping the balance in HIV-associated neurodegeneration. Neurotoxicity Research. In Revision.

73. Cisnero I, Borgmann K and Ghorpade A. Methamphetamine-induced activation of trace amine

associated receptor (TAAR) 1 regulates astrocyte excitatory amino acid transporter (EAAT)-2 via differential CREB phosphorylation during HIV-associated neurocognitive disorders (HAND). J. Biol Chem. In Revision.

Articles published in electronic journals: 1. Persidsky, Y., and Ghorpade, A. HIV-1 traffic: Cell-free, cell-associated and other CNS

activating stories. AIDScience online. December 2001;1(17). http://aidscience.org/Articles/aidscience014.asp

2. Dhar, A., Deshpande, M. and Ghorpade, A. CCR3 Chemokine Receptor, xPharm, Elsevier

Science, 2004, http://www.xpharm.com/citation?Article_ID=256. 3. Dhar, A., Deshpande, M. and Ghorpade, A CCR8 Chemokine Receptor, xPharm, Elsevier

Science, 2004, http://www.xpharm.com/citation?Article_ID=261. Articles submitted for publication: d. Books: None e. Chapters in books: 1. Krishnan, T., Chandrasekhar, S., Ghorpade, A., Sridhar, P., Singh, O., Garg, L. C., Hasnain, S.

E. and Talwar, G. P. Approaches to recombinant hCG birth control vaccine. In: Recombinant and synthetic vaccines. Talwar GP, Rao KVS, and Chauhan VS (Eds). Narosa Publishing House, New Delhi, 1994; 207-215.

2. Ghorpade, A. Laboratory model systems for microglia-HIV interactions. In: Neurology of AIDS.

Gendelman HE, Lipton S, Epstein L, Swindells S (Eds). Chapman and Hall, 1997; p86-96.

Anuja Ghorpade, Ph.D. Curriculum Vitae 3. Gendelman, H. E., Ghorpade, A. and Persidsky, Y. The neuropathogenesis of HIV-1 dementia.

In: In defense of the brain. Peterson and Remington (Eds), Blackwell Sci, 1997; p290-304. 4. Ghorpade, A. and Gendelman, H. E. Non-neuronal interactions in HIV-1-associated dementia.

In: Advances in Molecular and Cell Biology. (Ed.) E. E. Bittar. Academic Press, Oxford, 31:901-921 2004.

5. Ghorpade, A., Brichacek, B and Bukrinsky, M. Molecular biology of HIV-1. In: The neurology of

AIDS. Second edition. Gendelman, H.E., Swindells, S., Grant, I., Everall, I., Lipton, S. (Eds.) Oxford University Press. In press, 2005.

6. Borgmann K., Gendelman H.E. and Ghorpade A. Protocols for isolation, cultivation and viral

infection of fetal and adult microglia. In: Methods in Molecular Biology, Human Retrovirus protocols, Virology and Molecular Biology, T. Zhu (Ed). Humana Press, Inc. Totowa. 304:49-70, 2005.

7. Ghorpade, A. and Kipnis, J. Microglia, macrophages and dendritic cells: Biology and Function,

in the Textbook for Journal of Neuroimmune Pharmacology, Springer, 2008. 8. Dasgupta, S., Jana, M., Ghorpade, A., and Pahan, K. Astrocytes and oligodendrocytes: biology

and function, in the Textbook for Journal of Neuroimmune Pharmacology, Springer, 2008. 9. Banerjee S and Ghorpade A. Chapter 11: Astrocyte CD38: Links to neuroinflammation in

HAND. In Pathogenesis of Encephalitis, In Tech, 169-182. 2011.

f. Books or journals edited – none g. Abstracts & preliminary communications (Over past ten years at UNTHSC, total over 150): 1. Chao, C., Borgmann, K., Persidsky, R., Wu, L., and Ghorpade, A. Tissue inhibitor of

metalloproteinases-1 (TIMP-1)-mediated neuroprotection in neuroinflammation: Relevance to HIV-1-associated dementia (HAD) SFN Conference 2007

2. Kou, W., Banerjee, S., Borgmann, K. WU, L., Persidsky, R., Reyelts, C. and Ghorpade, A. Immune-activated astrocytes accompanied by altered CD38/cADPR signaling and impaired glutamate clearance: Mechanistic links to HIV-1-associated dementia. INSV 2007

3. Chao, C., Borgmann, K., Holter, S., Persidsky, R., WU, L., and Ghorpade, A. IL-1B mediated regulation of astrocyte tissue inhibitor of metalloproteinases-1 (TIMP-1): neuroprotective mechanisms beyond regulation of MMP activities. 14th SNIP Conference, Charolette, SC, March, 2008.

4. Kou, W., Banerjee, S., Borgmann, K., Wu, L., Persidsky, R., and Ghorpade, A. Role of CD38 in IL-1β-induced astrocyte glutamate clearance impairment. INSV conference, Fort Worth, TX. October 2008

5. Fields, JA., Borgmann, K., and Ghorpade, A., CCAAT Element Mediated Regulation of Astrocyte-TIMP-1 Expression in Chronic Neuroinflammation. 15th SNIP Conference, Wuhan, China on April 21-24, 2009.

6. Fields, JA. Kathleen Borgmann, K., Ghorpade, A. C/EBPβ is Expressed in Astrocytes During Neuroinflammation and Contributes to TIMP-1 Regulation. 16th SNIP Scientific Conference, Manhattan Beach, CA. April 13-17, 2010.

Anuja Ghorpade, Ph.D. Curriculum Vitae 7. Fields, JA. Kathleen Borgmann, K., Ghorpade, A. C/EBPβ is Expressed in Astrocytes During

Neuroinflammation and Contributes to TIMP-1 Regulation. RAD, UNTHSC April 23rd, 2010. 8. Kaur, M., Tang, L., Borgmann, K., Banerjee,S., Walseth, T.F. and Ghorpade, A. Astrocyte

CD38 Regulation in Neurodegenerative Disorders such as HIV- Associated Dementia. RAD, UNTHSC April 23rd, 2010.

9. Vartak, N., Borgmann, K., Tang, L., and Ghorpade, A. Astrocyte Elevated Gene-1 contributes to HIV-1 Associated Dementia by modulating astrocyte responses to inflammation, injury and stress. RAD, UNTHSC April 23rd, 2010.

10. Fields JA, Borgmann K, Tang L, Ghorpade A. IL-1β signals through p38 and ERK to Regulate Astrocyte C/EBPβ and TIMP-1. Alzheimer's Assocoation Spring Symposium March 31, 2011

11. Kaur M, Borgmann K, Tang L and Ghorpade A. CXCL8 is regulated in activated astrocytes through machemokine PKs and SHP2. RAD, UNTHSC April 1st, 2011

12. Ashutosh, Borgmann K, TangL, Labhasetwar V, Ghorpade A. A gene therapeutic approach for HIV-1 associated Dementia using targeted Nano particles for tissue inhibitor metalloproteinases-1 delivery into central nervous system. RAD, UNTHSC April 1st, 2011

13. Cisneros I, Borgmann K, Tang L, Ghorpade A. Effects of HIV-1 and Methamphetamine on the expression of excitatory amino acid transporter-2 and trace amine associated receptor1 in astrocytes. RAD, UNTHSC April 1st, 2011

14. Vartak N, Borgmann K, Tang L, Ghorpade A. Astrocyte Elevated Gene-1 Contributes to HIV-1-Associated Dementia by Modulating Astrocyte Responses to Inflammation, Injury and Stress. RAD, UNTHSC April 1st, 2011

15. Fields JA, Borgmann K, Tang L, Ghorpade A. IL-1β signals through p38 and ERK to Regulate Astrocyte C/EBPβ and TIMP-1. RAD, UNTHSC April 1st, 2011

16. Ashutosh, Borgmann K, Tang L, LabhasetwarV, Ghorpade A. A gene therapeutic approach for HIV-1 associated Dementia using targeted Nano particles for tissue inhibitor metalloproteinases-1 delivery into central nervous system. 17th SNIP, Clearwater Beach, FL. April 6-10th, 2011

17. Vartak N, Borgmann K, Tang L, Ghorpade A. Astrocyte Elevated Gene-1 Contributes to HIV-1-Associated Dementia by Modulating Astrocyte Responses to Inflammation, Injury and Stress. 17th SNIP, Clearwater Beach, FL. April 6-10th, 2011

18. Lerma T, Vartak N, Borgmann K, Tang L, Ghorpade A. Role of Astrocyte Elevated Gene-1 in Modulating Astrocyte Responses to Oxidative Stress. UNTHSC summer student poster presentations. July 28th, 2011

19. Lerma T, Vartak N, Borgmann K, Tang L, Ghorpade A. Role of Astrocyte Elevated Gene-1 in Modulating Astrocyte Responses to Oxidative Stress. Annual Biomedical Research Conference for Minority Students (ABRCMS) November 11, 2011

20. Fahim, Y, Borgmann K, Tang L, Ghorpade A. HIV-associated Neurocognitive Disorder and the effect of Antiretrovial Therapy on inflammatory response. UNTHSC summer student poster presentations. July 2012.

21. Fahim, Y, Borgmann K, Tang L, Ghorpade A. HIV-associated Neurocognitive Disorder and the effect of Antiretrovial Therapy on inflammatory response. Annual Biomedical Research Conference for Minority Students (ABRCMS) November 2012

22. Mamik, MK., Tang, L., Borgmann, K., and Ghorpade, A. SRC homology-2 domain containing protein Typrosine Phosphates (SHP)2 and P38 Regulate the Expression of Chemokine CXCL8 in Human Astrocytes. RAD, UNTHSC April 13th, 2012

Anuja Ghorpade, Ph.D. Curriculum Vitae 23. Mamik, MK., Tang, L., Borgmann, K., and Ghorpade, A. SRC homology-2 domain containing

protein Typrosine Phosphates (SHP)2 and P38 Regulate the Expression of Chemokine CXCL8 in Human Astrocytes. RAD, UNTHSC April 13th, 2012

24. Cisneros I, Borgmann K, Ghorpade A. Astrocyte Trace Amine Associated Receptor-1 induced cAMP regulates Excitotoxicity: A Mechanistic communality of METH and HIV-1 induced Neurotoxicity.RAD, UNTHSC April 13th, 2012

25. Ashutosh, Chao, C, Borgmann K, Tang L, and Ghorpade A.TIMP-1 protects human neurons from staurosporine and HIV-1-induced apoptosis: Mechanisms and relevance to HIV-1--associated neurological disorders. RAD, UNTHSC April 13th, 2012.

26. Ashutosh, Chao, C, Borgmann K, Tang L, and Ghorpade A. TIMP-1 protects human neurons from staurosporine and HIV-1-induced apoptosis: Mechanisms and relevance to HIV-1--associated neurological disorders. SNIP 18th Scientific Conference — April 25-28, 2012 Honolulu, Hawaii

27. Cisneros I, Borgmann K, Ghorpade A. Astrocyte Trace Amine Associated Receptor-1 induced cAMP regulates Excitotoxicity: A Mechanistic communality of METH and HIV-1 induced Neurotoxicity. SNIP 18th Scientific Conference — April 25-28, 2012 Honolulu, Hawaii

28. Vartak N and Ghorpade A. Astrocyte Elevated Gene-1 Regulates Astrocyte Responses to Inflammation: Implications for HIV-1 CNS Infection. 11th International Symposium on NeuroVirology, May 29th – June 2nd, 2012, New York, New York.

29. Mamik, MK., Tang, L., Borgmann, K., and Ghorpade, A. SRC homology-2 domain containing protein Typrosine Phosphates (SHP)2 and P38 Regulate the Expression of Chemokine CXCL8 in Human Astrocytes. 11th International Symposium on NeuroVirology, May 29th – June 2nd, 2012. New York, New York.

30. Vartak N and Ghorpade A. Astrocyte Elevated Gene-1 Regulates Astrocyte Responses to Inflammation: Implications for HIV-1 CNS Infection. 11th ISNI congress Boston, MA. November 4th - 8th, 2012

31. Cisneros and Ghorpade A.Transient methamphetamine-associated hyperthermia modulates astrocyte cyclic adenosine monophosphate (cAMP) levels and exacerbates HIV-1-associated neurotoxicity. SNIP 19th Scientific Conference April 3-6, 2013. San Juan, Puerto Rico.

32. Mamik, MK., Tang, L., Borgmann, K., and Ghorpade, A. Chemokine CXCL8 modulates HIV-1 replication in human monocyte-derived macrophages. SNIP 19th Scientific Conference April 3-6, 2013. San Juan, Puerto Rico

33. Ashutosh and Ghorpade A. A Nanotechnology approach to protect human neurons from oxidative stress. SNIP 19th Scientific Conference April 3-6, 2013. San Juan, Puerto Rico.

34. Vartak N and Ghorpade A. Astrocyte Elevated Gene-1 Regulates Astrocyte Responses to Inflammation: Implications for HIV-1 CNS Infection. SNIP 19th Scientific Conference April 3-6, 2013. San Juan, Puerto Rico

35. Ashutosh and Ghorpade A. A Nanotechnology approach to protect human neurons from oxidative stress. Research Appreciation Day. April 12, 2013. UNTHSC, Fort Worth, TX.

36. Cisneros and Ghorpade A. Transient methamphetamine-associated hyperthermia modulates astrocyte cyclic adenosine monophosphate (cAMP) levels and exacerbates HIV-1-associated neurotoxicity. Research Appreciation Day. April 12, 2013. UNTHSC, Fort Worth, TX.

37. Mamik, MK., Tang, L., Borgmann, K., and Ghorpade, A. Chemokine CXCL8 Modulates HIV-1 Replication in Human Monocyte-Derived Macrophages. Research Appreciation Day. April 12, 2013. UNTHSC, Fort Worth, TX.

Anuja Ghorpade, Ph.D. Curriculum Vitae 38. Vartak N and Ghorpade A. Astrocyte Elevated Gene-1 Regulates Astrocyte Responses to

Inflammation: Implications for HIV-1 CNS Infection. Research Appreciation Day. April 12, 2013. UNTHSC, Fort Worth, TX.

39. Taylor T, Pandya A, Borgmann K and Ghorpade A. Biomarkers for HIV-1 Disease Progression. UNTHSC summer student poster presentations. July 2013.

40. Pandey R and Ghorpade A. Role of Alcohol in Primary human astrocytes. Research Appreciation Day. March 21, 2014. UNTHSC, Fort Worth, TX.

41. Joshi CR and Ghorpade A. HIV-1 Tat Expression alters Human Astrocyte inflammatory biomarker profiles and glutamate metabolism. Research Appreciation Day. March 21, 2014. UNTHSC, Fort Worth, TX.

42. Borgmann K, Tang L and Ghorapde A. Biological Congruence between Physiological and Inflammatory markers in Primary Human Astrocyte Model of Neurodegeneration Research Research Appreciation Day. March 21, 2014. UNTHSC, Fort Worth, TX.

43. Shelake S and Ghorpade A. Implications of Astrocytic NRF2-ARE Signaling pathways in Methamphetamine and HIV gp120 induced Oxidative stress. Research Appreciation Day. March 21, 2014. UNTHSC, Fort Worth, TX.

44. Cisneros IE and Ghorpade A. Methamphetamine Regulates Astrocyte excitatory Amino Acid Transporter-2 via Activation of Trace Amine Associated Receptor and Downstream cAMP signaling. Research Appreciation Day. March 21, 2014. UNTHSC, Fort Worth, TX.

45. Singhal A and Ghorpade A. Tumor Necrosis Factor-α confers cytotoxicity in astrocytes under Oxidative Stress via inhibition of NF-κB signaling. Research Appreciation Day. March 21, 2014. UNTHSC, Fort Worth, TX.

46. Cisneros IE and Ghorpade A. Methamphetamine Regulates Astrocyte excitatory Amino Acid Transporter-2 via Activation of Trace Amine Associated Receptor and Downstream cAMP signaling. SNIP 20th Scientific Conference March 27–30, 2013. New Orleans, LA.

47. Shenoy S, Borgmann K, Atkinson B, Nejtek V and Ghorpade A. Health disparities and novel biomarkers for HIV-1 disease progression. 9th annual Texas conference on Health Disparities. UNTHSC. May 29-30, 2014. Fort Worth, TX.

48. Ghorpade A, Gardner-Mercer J, Fields JA, Singhal A, Morris V. and Labhastwar V. Astrocyte Activation in HIV-1 CNS Disease: the TIMPed Balance of of Neuroinflammation. Glia in Health & Diseases. July 17–21, 2014. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.

49. Shenoy S, Borgmann K, Atkinson B, Nejtek V and Ghorpade A. Health Disparities & Novel Biomarkers for HIV-1 Associated Neurocognitive Disorders. 2014 Texas HIV-STD Conference Texas Department of State Health Services. August 19-21, 2014. Austin, TX.

50. Taylor T, Pandya A, Borgmann K and Ghorpade A. Biomarkers for HIV-1 Disease Progression. Annual Biomedical Research Conference for Minority Students (ABRCMS) November 2014.

51. Joshi CR, and Ghorpade A. HIV-1 Tat expression alters human astrocyte inflammatory biomarker profiles and glutamate metabolism, Research Appreciation Day, Fort Worth, TX, 2014.

52. Bowen K, Borgmann K, Ghorpade A, Mathew P. Natural Cytotoxicity Receptor NKp44 and NK - Astrocytes interactions in HIV-associated Neurocognitive Disorders. American Association of Immunologist Annual Meeting. May 8-12, 2015. New Orleans, LA.

53. Joshi, C. R. and Ghorpade, A. HIV-1 Tat and gp120 regulate astrocyte tissue inhibitor of matrix metalloproteinases-1 (TIMP)-1. 23rd Annual Research Appreciation Day, UNTHSC, Fort Worth, TX. April 17, 2015. (1st prize, Poster Presentation for Dept. of Cell Biology and Immunology; 2nd prize, Poster Presentation, Robert J. Wordinger Award for Virology)

Anuja Ghorpade, Ph.D. Curriculum Vitae 54. Nooka S. and Ghorpade A. Astrocyte AEG-1 regulation of Wnt/β-catenin signaling in HAND.

23rd Annual Research Appreciation Day, UNTHSC, Fort Worth, TX. April 17, 2015. 55. Pandey, R. and Ghorpade A. Alcohol regulates HIV-1-mediated astrocyte inflammatory

responses by cPLA2. 23rd Annual Research Appreciation Day, UNTHSC, Fort Worth, TX. April 17, 2015.

56. Joshi, C. R. and Ghorpade, A. HIV-1 Tat and gp120 Regulate astrocyte tissue inhibitor of matrix metalloproteinases-1 (TIMP)-1. 21st Annual SNIP Conference, Miami, FL. April 22-25, 2015.

57. Pandey, R. and Ghorpade A. Alcohol regulates HIV-1-mediated astrocyte inflammatory responses by cPLA2. 21st Annual SNIP Conference, Miami, FL. April 22-25, 2015

58. Borgmann, K, Cisneros, IE and Ghorpade, A. Regulation of Astrocyte-Trace Amine Associated Receptor 1 Subcellular Distribution and Interacting Partners in the context of Methamphetamine and HIV-Associated Neurocognitive Disorders. Behavior, Biology and Chemistry Conference. San Antonio, TX. March 4-6, 2016.

59. Borgmann, K, Cisneros, IE and Ghorpade, A. Regulation of Astrocyte-Trace Amine Associated Receptor 1 Subcellular Distribution and Interacting Partners in the context of Methamphetamine and HIV-Associated Neurocognitive Disorders. 22nd SNIP Conference Krakow, Poland. April 6-9, 2016. (2nd place poster award)

60. Nooka S. and Ghorpade A. Astrocyte AEG-1 regulates ER stress responses in HAND. 22nd SNIP Conference. Krakow, Poland. April 6-9, 2016.

61. Pandey, R. and Ghorpade A. Alcohol and HIV-1 differentially regulate Toll Like Receptor (TLRs) expression and signaling in Primary Human Astrocytes. 22nd SNIP Conference, Krakow, Poland. April 6-9, 2016.

62. Borgmann, K, Cisneros, IE and Ghorpade, A. Regulation of Astrocyte-Trace Amine Associated Receptor 1 Subcellular Distribution and Interacting Partners in the context of Methamphetamine and HIV-Associated Neurocognitive Disorders. 24th Annual Research Appreciation Day. UNTHSC, Fort Worth, TX. April 15, 2016.

63. Joshi C.R., Labhasetwar V. and Ghorpade A. Polymeric nanoparticles for gene delivery to human astrocytes. 24th Annual Research Appreciation Day. UNTHSC, Fort Worth, TX. April 15, 2016. (1st prize, Poster Presentation for Dept. of Cell Biology and Immunology; 2nd prize, Poster Presentation, Robert J. Wordinger Award for Virology)

64. Nooka S. and Ghorpade A. Astrocyte AEG-1 regulates ER stress responses in HAND. 24th Annual Research Appreciation Day. UNTHSC, Fort Worth, TX. April 15, 2016.

65. Pandey, R. and Ghorpade A. Alcohol and HIV-1 differentially regulate Toll Like Receptor (TLRs) expression and signaling in Primary Human Astrocytes. 24th Annual Research Appreciation Day. UNTHSC, Fort Worth, TX. April 15, 2016.

66. Edara, VVC and Ghorpade, A. Methamphetamine Effects on Astrocyte HIV-1 Reservoirs in HAND Pathogenesis. Research Appreciation Day. University of North Texas Health Science Center, Fort Worth, TX, April 2016.

67. Joshi C.R., Labhasetwar V. and Ghorpade A. Polymeric nanoparticles for gene delivery to human astrocytes. Society for Personalized Nanomedicine, Florida International University. Miami, FL. May 18, 2016 (NeuroHIV New Investigator Award)

68. Pandey, R. and Ghorpade A. Alcohol and HIV-1 differentially regulate Toll Like Receptor (TLRs) expression and signaling in Primary Human Astrocytes. NeuroHIV and Alcohol Abuse satellite meeting, Florida International University. Miami, FL May 18, 2016

Anuja Ghorpade, Ph.D. Curriculum Vitae 69. Borgmann, K, Cisneros, IE and Ghorpade, A. TAARgeting Astrocytes during HIV-Associated

Neurocognitive Disorders and Methamphetamine Abuse. 10th Annual JPS Research Day. Fort Worth TX. June 3, 2016. (2nd place oral presentation award)

70. Edara, VVC and Ghorpade, A. Resolving Astrocyte Latent Reservoirs In The Brain For HIV Cure. Cell & Gene Therapy for HIV Cure. Seattle, Washington, August 2016.

71. Borgmann, K, and Ghorpade, A. TAARgeting Astrogliosis & Mitochondrial Dysfunction during METH exposure & HIV-Relevant Neuroinflammation. Behavior, Biology and Chemistry Conference. San Antonio, TX. March 3-5, 2017.

72. Pandey, R. and Ghorpade A. TLR4 regulates alcohol-mediated astrocyte inflammation via cPLA2 signaling in HAND. 23rd Annual SNIP conference, Philadelphia, PA Mar 29-April 1, 2017.

73. Borgmann, K and Ghorpade, A. TAARgeting Astrocyte Mitochondrial Dysfunction during HIV-associated Neuroinflammation and METH Exposure. 23rd Annual SNIP conference, Philadelphia, PA Mar 29-April 1, 2017. (Outstanding Pre-Doctoral Oral Presentation)

74. Joshi C.R., Labhasetwar V. and Ghorpade A. Polymeric nanoparticle (NP)-mediated gene delivery to human astrocytes. 23rd Annual SNIP conference, Philadelphia, PA Mar 29-April 1, 2017.

75. Edara, VVC and Ghorpade, A. Red/Green Astrocytes Mimic CNS Viral Reservoirs in post ART HAND: Implications for METH abuse. Society on Neuroimmune Pharmacology, Hotel Double Tree by Hilton, Philadelphia Center City, Philadelphia, PA, March 2017.

76. Borgmann, K and Ghorpade, A. TAARgeting Astrocyte Mitochondrial Dysfunction during HIV-associated Neuroinflammation and METH Exposure. 25th Annual Research Appreciation Day, UNTHSC, Fort Worth, TX. April 7, 2017.

77. Joshi C.R., Labhasetwar V. and Ghorpade A. Polymeric nanoparticle (NP)-mediated gene delivery to human astrocytes. 25th Annual Research Appreciation Day, UNTHSC, Fort Worth, TX. April 7, 2017.

78. Nooka S. and Ghorpade A. Interleukin-1β and abacavir induce astrocyte ER stress during HAND. 25th Annual Research Appreciation Day, UNTHSC, Fort Worth, TX. April 7, 2017. (Poster award, Robert J. Wordinger Award for Virology)

79. Pandey, R. and Ghorpade A. TLR4 regulates alcohol-mediated astrocyte inflammation via cPLA2 signaling in HAND. 25th Annual Research Appreciation Day, UNTHSC, Fort Worth, TX. April 7, 2017.

80. Edara, VVC and Ghorpade, A. Red/Green Astrocytes Mimic CNS Viral Reservoirs in post ART HAND: Implications for METH abuse. Research Appreciation Day, University of North Texas Health Science Center, Fort Worth, TX, April 2017.

81. Borgmann, K, and Ghorpade, A. TAARgeting Astrocyte Mitochondrial Dysfunction during HIV-associated Neuroinflammation and METH Exposure. Neurobiology of Aging Symposium. UNTHSC, Fort Worth, TX. May 10th, 2017. (James W. Simpkins Predoctoral Award)

h. Presentations (selected): 1. "Cellular Immunology of microglia and HIV-1," Immunology Interest Group, UNMC, March 2000. 2. “Neuron-Glia Interactions”, CNND Neuroscience Lecture Series, UNMC, September 2000. 3. International Neuroimmunology Congress, “IL-1beta-activated astrocytes express Fas ligand:

Novel pathways to neuronal injury in HIV-1-associated dementia“ Edinburgh, UK September 2001.

Anuja Ghorpade, Ph.D. Curriculum Vitae 4. 31st Annual Meeting of Society for Neuroscience, “IL-1beta-activated astrocytes express Fas

ligand: Novel pathways to neuronal injury in HIV-1-associated dementia.“ San Diego, CA November 2001.

5. 4th International Symposium on NeuroVirology and 10th Conference on neuroscience of HIV

infection, “IL-1beta-activated astrocytes express Fas ligand: Novel pathways to neuronal injury in HIV-1-associated dementia.” Düsseldorf, Germany, June 2002.

6. Invited presentation at the Young Investigators Forum – Workshop on “Astrocyte Function in

Health and Disease,” sponsored by the National Institute of Neurological Diseases and Stroke, Rockville, MD, September 22-25, 2002.

7. Invited presentation at the Young Investigators Forum – Workshop on “Glial Inflammation in

HIV-1 Dementia and Other chronic Neurodegenerative Diseases,” sponsored by National Institute of Neurological Disorders and Stroke, National Institutes of Mental Health and National Institutes of Aging, Washington, DC, December 7-10, 2003.

8. Invited presentation at Department of Biochemistry and Molecular Biology, February 2, 2004. 9. Invited presentation at the Center for Immunology, Department of Microbiology, University of

Albany, May 2004. 10. 38th Winter Conference on Brain Research, “Glial Inflammation and Neurodegeneration.”

Breckenridge, Colorado, January 2005. 11. Invited presentation at the Redox Center, University of Nebraska, Lincoln, September 2005. 12. UNMC mini-medical school, “Raising the bar in brain research”, October 13th, 2005. 13. Invited presentation at Liver Study Unit seminar series, Dept. of Internal Medicine, UNMC,

November 2005. 14. Invited presentation at the Department of Pharmacology and Physiology, Drexel University,

March 2006. 15. The UNMC/UNL/ISU/Ames Laboratory Retreat "Micro/Nanosystems for Diagnostics and

Therapeutics". Panel discussion on Neurodegenerative Diseases and Nanomedicine Mahoney State Park, Omaha, NE, May 12, 2006.

16. Invited presentation at the 7th International Society for NeuroVirology Conference. “IL-1β-

activated astrocyte inflammatory profiles: Upregulation of CD38 and implications for astrocyte-mediated neurotoxicity in HIV-1 dementia”, Philadelphia, PA, May 30-31, 2006.

17. Invited presentation, “Glial inflammatory responses in HIV-1-associated dementia: lessons for

neurodegenerative disease”, UNT Health Science Center, University of North Texas, June 6, 2006.

18. “Stem Cell Research and Brain Diseases” at the Neurological disorders Workshop, Methodist

College, Omaha, NE, September 8, 2006.

Anuja Ghorpade, Ph.D. Curriculum Vitae 19. Invited presentation, “Role of astrocytes in neuroinflammation and HIV-1 dementia: CD38 and

other stories”, University of Minnesota, Department of Pharmacology, October 2006. 20. UNMC mini-medical school, “Adult stem cells”, panel discussion, November 2, 2006. 21. Invited presentation, “Building a Rapid Autopsy Program in an Academic Institution: Lessons

from Nebraska”, University of North Texas Health Science Center, Ft. Worth, TX, February 26-27, 2007.

22. 13th SNIP Conference, Invited presentation on “Glial inflammatory responses in HIV-1-

associated dementia”, Salt Lake City, Utah, April 11-15, 2007. 23. Invited presentation, “Glial Inflammatory Responses in HIV-1 CNS Disease: Role of MMP/TIMP

Regulation”, International Conference on Opportunistic Infections and AIDS, New Delhi, India, January 2008.

24. Invited presentation, “Tissue Inhibitor of Metalloproteinase-1 in HIV-1 Dementia: The

Unexpected Neuronal Defender”, UNTHSC, January 27 2008. 25. Invited presentation, “Building a Rapid Autopsy Program in an Academic Institution: Lessons

from Nebraska”, UNTHSC, February 26 2008. 26. Invited presentation on “Glial inflammatory responses and Neurodegeneration.” University of

Missouri at Kansas City, March 2008. 27. Invited presentation on “Glial inflammatory responses and Neurodegeneration.” Louisiana State

University, April 2008. 28. Invited presentation on “The ‘Yin and Yang’ of Glial Inflammation in HIV-1 dementia”, UNTHSC,

Dept of Pharmacology and Neuroscience, October 2008. 29. International Society on Neuroimmunology, Presenter, “Glial Inflammatory Responses in HIV-1

CNS Disease, Role of MMP/TIMP regulation,” Fort Worth, TX, October 26 2008. 30. National Institute of Pharmaceutical Education and Research, Conf. on Biotechnological

Approaches to Neuroimmunomodulation and Infectious Diseases. Invited Presentation on “Inflammatory Responses of Glia in HIV-1-associated dementia: Can TIMP-1 trump the neurodegenerative process?”, Chandigarh, India, December 11 2008.

31. International Conference on Molecular Medicine Invited Speaker on “Glial Inflammatory

Responses in HIV-1 CNS Disease, Role of MMP/TIMP regulation,” Chennai, India, January 18 2009.

32. Invited Presentation: Glial Responses in HIV-1-Associated Neurological Disease, M. S. Univ.

Baroda, Gujarat, January 2009. 33. Invited presentation on “HIV-Associated Neurocognitive Disorders,” UNTHSC, Texas Center for

Health Disparities Seminar, February 2009. TCHD

Anuja Ghorpade, Ph.D. Curriculum Vitae 34. Invited presentation on “Inflammatory responses of astrocytes in HIV-1 CNS disease,” Chinese

Academy of Sciences - Beijing, China, April 20 2009. 35. 14th SNIP Conference, Invited Speaker, “Inflammatory Responses of Activated Glia: Lessons

from HIV-1-associated Dementia,” Wuhan, China, April 28 2009. 36. Invited presentation: “The ‘TIMP’ed balance in Neuroinflammation: Lessons from HIV/AIDS,”

UNTHSC, CGEN current research seminar, September 2009. 37. Featured speaker in the series 'Careers for Women' - The Biomedical Sciences; Girl Scouts,

Aledo, TX, September 2009. 38. Invited presentation: International Conference on Opportunistic Infections and AIDS, New Delhi,

“Effects of METH on HIV-1 infection” Sept 27-30, 2010. 39. Invited presentation: “Regulation of Astrocyte Tissue Inhibitor of Metalloproteinase-1 in HIV-1-

associated dementia” Indiana University, October 2010. 40. Invited presentation: “Astrocyte activation in HIV-1 CNS disease: The TIMPed balance of

neuroinflammation” Drexel University, June 2011. 41. Invited presentation: “Inflammatory responses of astrocytes in HIV-1-associated neurological

disease.” Mechanisms of Neurodegeneration in CNS Diseases" Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases. Hamilton, Montana. August 18-19th, 2011.

42. Invited presentation: “HIV-1, Methamphetamine and Astrocytes: Combined Excitotoxic

implications for Neuro-AIDS.” Indian Pharmacological Society, Manipal University, Manipal India. December 19th - 21st 2011.

43. Invited presentation: “HIV-1, Methamphetamine and Astrocytes: Combined Excitotoxic

implications for Neuro-AIDS.” 3rd Biotechnology Congress, OMICS, Hyderabad, India, September 13-15, 2012.

44. Invited presentation: “Astrocyte responses and Neuroinflammation: AEG-1, Methamphetamine

and Other stories” Temple University, Philadelphia, PA. October 4-5, 2012. 45. Invited award winner presentation: UNTHSC GSBS, Outstanding Graduate Faculty Seminar

Series “Astrocyte Responses in Neuro-AIDS Methamphetamine Abuse and Other Stories on the ‘TIMP’-ed Balance of Neuroinflammation.” UNTHSC, Fort Worth, TX. November 28th, 2012.

46. Invited presentation: “A Nanotechnology Approach to Protect Human Neurons and Glia from

Oxidative Stress.” First Personalized Nanomedicine Symposium, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, February 18, 2013.

47. Invited presentation: “Neuroinflammatory responses of astrocytes in Neuro-AIDS.” Texas Tech

Univ. Health Science Center, El Paso, TX. May 16, 2013. 48. Invited presentation: “Astrocyte elevated gene 1 (AEG-1) in HAND and Aging” 2014 International

Society on Aging and Disease. Beijing International Convention Center, China, on November 1-2, 2014

Anuja Ghorpade, Ph.D. Curriculum Vitae 49. Invited presentation: “Modifying Nanoformulations for Challenging Targets: Astrocytes and

Neurons” Third Personalized Nanomedicine Symposium, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, 2015.

50. Invited presentation: “Alcohol influences HAND via astrocyte-TLRs and cPLA2 cross-talk”

Louisiana State Univ Health Science Center, New Orleans, LA, October 13, 2016. 51. Invited Panel Member: Bio-North-TX 2nd Annual Life Sciences Summit, Univ of Arlington, Fort

Worth, TX, October 26, 2016. 52. Invited Presentation: “Destination Brain: Targeting astrocytes in HIV-1 infection”. 4th Annual

Society for Personalized Medicine Symposium. Miami, FL, November 3, 2017.

i. “Published” audiovisual educational material: Prepared five podcasts for Designated Self

Study for medical students (Cellular Science) j. “Published” continuing education materials: None k. “Published” computer software: None

Teaching Activities: a. Listing of lectures given in team-taught courses (include number of lectures)

Pharmacy students Biochemistry 541 (UNMC) Lecture(s) in AIDS, Alzheimer’s Disease and other Neurodegenerative Disorders

Two lecture hours each: Spring 2003 One lecture hour each: Spring 2001, 2002. 2004, 2005, 2006, 2007

M-2 HIV and Other Retroviruses (UNMC) One lecture hour each: Fall 2001, 2002, 2003, 2005, 2006

Problem-Based Learning M1 (UNMC) Five hours/case discussion

Fall 2000, 2001

BRTP 821 (UNMC) Lecture series in nucleic acids: Macromolecular Structure and Function Six lecture hours: Fall 2001 Four lecture hours each: Fall 2004, 2005, 2006

PAMM 950 Special Topics: Neuroimmunology (UNMC) Lectures series: HIV Biology; Glial Immunity-Astrocytes and Oligodendrocytes; Glial Immunity-Microglia Three lecture periods/1.5 hours each Four & a half lecture hours each: Spring 2004, 2005, 2006, 2007 BIOC 926 (UNMC)


Nucleic Acid Structure and Function Lecture series: Nucleic acid structure, DNA topology, Structure - Function relationship Three lecture periods/2 hours each Six lecture hours each: Fall 2005, 2006 Pharmacology 507 (UNMC) Pharmacology for Physician Assistant Students One lecture hour: Spring 2007 Cellular Science - CELL 9110 (UNTHSC) Five lecture hours: Medical Academic Term 2008-2009, 2009-2010, 2010-2011, 2011-2012, 2012-13 Six lecture hours: Medical Academic Term 2013-2014 Biochemistry – BMSC 6301 (UNTHSC) Five lecture hours: Graduate School Academic term 2011-2012, 2012-2013 Molecular and Cell Biology – BMSC 6302 (UNTHSC) Fourteen lecture hours: Graduate School Academic term 2012-2013 Laboratory Management Course – BMSC 5250 (UNTHSC) Two lecture hours: Laboratory Leadership in Science, Graduate School Academic term 2013-14 Cell and Molecular Biology Sixteen contact hours. Medical Academic Term 2015-2016, Cell and Molecular Biology Eighteen contact hours. Medical Academic Term 2016-2017, 2017-2018

b. Listing of courses for which you were coordinator/supervisor:

Course Director: Pharmacology for Physician Assistant and Clinical Perfusion students, Spring 2007 (78 hours of lectures) Course Co-director: Pharmacology for Physician Assistant and Clinical Perfusion students (Course director: Dr. Jean Deupree), Spring 2006 (78 hours of lectures)

Course Director: Seminars, Current Topics Cell Biology and Anatomy/Immunology – CBAN 5140 (UNTHSC), Fall 2009, Spring 2010, Fall 2010, Spring 2011, Fall 2011, Spring 2012, Fall 2012, Spring 2013, Fall 2014, Spring 2015, Fall 2015, Spring 2016 Course Director: Individual Research - BMSC 6998 (UNTHSC), Fall 2009, Spring 2010, Fall 2010, Spring 2011, Fall 2011, Spring 2012, Fall 2012, Spring 2013, Fall 2013, Spring 2014, Fall 2014, Spring-Summer-Fall 2015, Spring 2016

Course Director: Special Problems - CBAN 5900 (UNTHSC), Summer 2009, Spring 2010, Fall 2010, Fall 2011, Spring 2012, Fall 2012, Spring 2011 Course Director: Special Problems - CBAN 5910 (UNTHSC), Summer 2009, Fall 2014


Course Director: Individual Research - BMSC 6940 (UNTHSC), Summer 2009, Spring 2010, Fall 2010, Fall 2011, Spring 2012, Fall 2012, Spring 2013, Fall 2014, Spring 2015, Fall 2015, Spring 2016, Spring 2017 Course Director: Individual Research - MS Students - BMSC 5930 (UNTHSC), Spring 2009, Summer 2010, Fall 2014, Spring 2017 Course Director: Doctoral Dissertation - BMSC 6395 (UNTHSC), Spring 2011, Summer 2011, Fall 2011, Spring 2012, Fall 2012, Spring 2013, Fall 2014, Spring/Fall 2015, Spring 2016, Fall 2016, Spring 2017 Course Director: Lab Rotations - BMSC 5650 (UNTHSC), Spring 2009, Fall 2009, Spring 2011, Spring 2012, Fall 2012, Spring 2013, Spring/Fall 2014, Spring/Fall 2015, Spring 2016 Course Director: Advanced Cell Biology – MMED 6203, Spring 2017

c. Listing of courses (course number and name, only) taught by yourself giving the total hours involved in course/courses:

Molecular Biology of the Cell (UNO) Hours: 3 hour/class, 2 classes/week, 8 weeks (total 48 hours) Total 144 hours (Summer 2002, 2003, 2004) Microbiology BIO 205-8A (Metro Community College) Hours: 4hour/class, 2 classes/week, 10 weeks (total 80 hours) Total 80 hours (Summer 2001) Essentials of Cell Biology. UNTHSC online course (six weeks), 1 SCH, Spring 2015. Advanced Cell Biology – MMED 6203, 12 contact hours (2 weeks out of the 5-weeks course), Spring 2017

d. Information on teaching of Graduate students, especially as pertains to supervision of

thesis and dissertation research:

Graduate Students (PhD or MS) as Immediate Thesis Advisor and Chair, Graduate Supervisory Committee Training Period Student Current Status 2003-2007 : Jessica Gardner-Mercer Senior Technical Writer, University of Michigan Cancer Center 2006-2009 : Sugato Banerjee Assistant Professor, Birla Institute of

Technology, Mesra India 2006-2009 : Clara Y. Fugate (Chao) Navy Seaman, Great Lakes, IL 2008-2012 : Jerel A.Fields Assoc. Res Univ. California San Diego 2009-2013 : Neha Vartak Research scientist, IISc, India 2009-2013 : Manmeet Kaur Post-doc, Univ. of Alberta 2010-2015 : Irma Cisneros Post-doc, Univ. TX Med. Branch 2010- : Kathleen Borgmann Graduate Student, UNTHSC 2012-2017 : Shruthi Nooka Currently in India


2013- : Chaitanya Joshi Graduate Student, UNTHSC 2013-2015 : Mayuri Thete Technician, Univ. Cal. San Francisco 2015- : Venkata Edara Chawdry Graduate Student, UNTHSC 2017- : Shannon Mythen Graduate Student, UNTHSC Postdoctoral Fellows Primary Supervision Training Period Student Current Status 1998-1999 Jinan Al-O-Maishi, MD Deceased 5/2002-1/2003 Robin Cotter, PhD Assistant Professor, University of

Arizona 8/2003-7/2004 Alok Dhar, Ph.D. Research Technologist II,

Next Generation Sequencing Core, UNMC, Omaha, NE

7/2003-1/2006 Muralidhar Deshpande, PhD Associate Principal Scientist at Merck Animal Health 8/2006-11/2008 Wei Kou Physician scientist, China 7/2009-9/2014 Ashutosh Singhal Meharry Medical College, TN 9/2013-6/2017 Richa Sharma Post-doc, Unv TX South Western 6/2015-6/2016 Irma Cisneros Post-doc, Univ. TX Med. Branch 10/2017- Brian Molles Post-doc, UNTHSC Undergraduate Students Supervised (Research towards an honors thesis) Training Period Student Current Status 1999-2000 Christine Ann Labenz Emerg. Med. University Hospital San Antonio,

TX Matrix metalloproteinase production by astrocytes: Implications for HIV-1-associated dementia. Bachelor of Science, Magna cum laude, 2000

1999-2001 Radhika Suryadevara Orenco Station Medical Group,Hillsboro,

OR Undergraduate student with a NIH minority grant supplements conducting research on Molecular mechanisms of HIV neuropathogenesis.

2001-2002 Lori J. Todd, BS Independent study-BS degree 2005-2007 Alicia Hardt Rheumatology Fellow, Johns Hopkins Medicine Graduate Students (PhD or MS) Graduate Supervisory Committees (Incomplete) Training Period Student Current Status 2000-2003 : Alicia Lopez Nurse practitioner, University of

Arizona, Tucson 2004-2006 : Tao Jing 2004- 2007 : Yunlong Huang Instructor, UNMC College of Medicine 2005-2009 : Kavitha Rao Graduate Student, UNMC College of Pharmacy


2005-2009 : Gaurav Sahay Post-doctoral Fellow, UNMC College of Pharmacy 2005-2008 : Nathan Erdman Post-doctoral Fellow, UNMC

College of Medicine 2005-2009 : Edward Arvisais Post-doctoral research associate,

UNMC, Dept. of Obstetrics/Gynecology 2007-2008 : Irena Kadiu Post-doctoral research associate,

UNMC, Dept. of Pharmacology & Experimental Neuroscience

2007-2010 : Kalyan Nannuru Graduate Student, UNMC Dept. of Pathology/Microbiology 2010-2012 : Wanda Medina Visual Sciences, UNTHSC 2010-2012 : Tasneem Putliwala Visual Sciences, UNTHSC

Graduate Students (PhD or MS) Examination Committees Training Period Student Current Status 2001 : Karen Deffenbacher Senior Research Associate, UNMC 2002 : Amy Farrell Graduate Student, UNO 2004 : Pankaj Singh Graduate Student, UNMC 2009 : Sanjay Thamke Biomedical Sciences, UNTHSC 2009 : Nimrat Kaur Cell Biology, UNTHSC

2010-2012 : Wanda Medina Visual Sciences, UNTHSC 2010-2012 : Tasneem Putliwala Visual Sciences, UNTHSC

2010 : Shamika Smith Forensic Genetics, UNTHSC 2010-2012 : Michela Montecchi-Palmer Visual Sciences, UNTHSC

Medical Students (MD/MD/PhD) Research Supervision Training Period Student Current Status 2002 Summer Radhika Suryadevara Orenco Station Medical Group, Hillsboro, OR 2003 Summer Harvinder Deogan Desert Spine and Sports Physicians,

Phoenix AZ 2004 Summer Courtney Schellpeper St.Luke’s Hospital, Kansas City, MO 2005 Spring Radhika Suryadevara Orenco Station Medical Group, Hillsboro

2013 Summer/Fall Anjani Pandya Internal Medicine Resident Physician - UT 2013 Fall Miguel Nieto Emergency Medicine, Ben Taub Hospital,

Houston TX College Students Supervised Training Period Student Training Period Student 1994-Summer Meloney Goethen 1995-Summer Sheila Bush 1997-Summer William Williams 1998-Summer Christine Labenz 1999-Summer Sarah Eurek 2000-Summer Aaron Jacobs 2000-Summer Radhika

Suryadevara

2000-Summer Nicole Westfall 2001-Summer Courtney

Schellpeper 2001-Summer Mary Tadros 2001-Summer Ohm Suthar 2003-Summer Harvinder Deogan 2004-Summer Courtney Schellpeper


2005-Summer Alicia Hardt 2006-Summer Alicia Hardt 2007-Summer Alicia Hardt 2007-Summer Crystal Reynolds 2007-Summer Jeffrey Belmont 2008-Summer Ebony Collins 2009-Summer Jamilla Harris 2009-Summer Nona Kelly 2010-Summer Elena Vaughn

2011-Summer Tanya Lerma 2012-Summer Yasmin Fahim 2013-Summer Tracy Taylor 2014-Summer Rachael Odusanya 2015- Summer Kristian Menard 2016- Summer Ruayda Bouls 2017- Summer Rodolfo Jose Gonzales

e. Information on teaching activities related to those in residency training (medical,

pharmacy, etc.): N/A f. Listing of continuing education lectures/courses given: None

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