Revised: 7/26/10 CURRICULUM VITAE RICHARD A. WALSH, M.D. OFFICE ADDRESS: University Hospitals of Cleveland Department of Medicine 11100 Euclid Avenue, LKS-5029 Cleveland, OH 44106-5029 Tel: 216/844-3293; Fax: 216/844-3145 Email: Richard.Walsh@cwru.edu EDUCATION Undergraduate: Georgetown University B.S. Biology Cum Laude Washington, D.C. 1964-1968 Graduate: Georgetown University M.D. Magna Cum Laude 1968-1972 POSTGRADUATE TRAINING: Internship: University of North Carolina 1972-1973 Chapel Hill, North Carolina Internal Medicine Residency: Junior Assistant & Sr. Res. 1973-1975 University of North Carolina Internal Medicine Chapel Hill, North Carolina Post-Doctoral: Cardiology Fellowship with 1975-1977 Dr. W. Proctor Harvey Cardiology Georgetown University Hospital Washington, D.C.

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 2 ACADEMIC POSITIONS: John H. Hord Professor of Medicine, Case Western Reserve University, 1998-present Professor of Physiology and Biophysics, Case Western Reserve University, 1998-present. Mabel S. Stonehill Professor of Medicine, 1992-1998 Professor of Medicine and Pharmacology & Cell Biophysics - Department of Medicine, University of Cincinnati Medical Center, 1990-1998. Professor of Medicine - Division of Cardiology, Department of Medicine, The University of

Texas Health Science Center at San Antonio, 1987-1989. Associate Professor of Medicine - Division of Cardiology, Department of Medicine, The

University of Texas Health Science Center at San Antonio, 1982-1987. Assistant Professor of Medicine - Division of Cardiology, Department of Medicine, The

University of Texas Health Science Center at San Antonio, 1977-1982. Associate Foundation Scientist, Southwest Foundation for Biomedical Research, San Antonio, 1979-1987. Foundation Scientist, Southwest Foundation for Biomedical Research, San Antonio, 1987-1992. ADMINISTRATIVE RESPONSIBILITIES: Chair, Department of Medicine, Case Western Reserve University and Physician-in-Chief, University Hospitals Health System, Cleveland, Ohio, 2008-present. Chair, Department of Medicine, Case Western Reserve University and Physician-in-Chief, University Hospitals, Cleveland, Ohio, 1998-2008. Director, Division of Cardiology, University of Cincinnati Medical Center, Cincinnati, Ohio,

1990-1998. Director, Cardiovascular Fellowship Training Program, University of Cincinnati Medical

Center, Cincinnati Ohio, 1990-1995, 1998. Director, Cardiovascular Center, University of Cincinnati, 1991-1998. Director, Cardiac Catheterization Hemodynamics Laboratory, University of Texas Health

Science Center, San Antonio, 1977 -1989. Director, Cardiopulmonary Physiology Laboratory, Southwest Foundation for Biomedical

Research, San Antonio, 1979-1989. Director, Combined City-Wide Cardiology Conference, San Antonio, Texas, 1978-1989.

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 3 HOSPITAL STAFF APPOINTMENTS: Staff Physician, Medical Center Hospital, San Antonio, Texas, 1977-1989. Staff Physician, Audie L. Murphy Veterans Administration Hospital, San Antonio, Texas,

1977-1989. Staff Physician, University Hospital, Cincinnati, Ohio, 1990-1998. Staff Physician, Veterans Administration Hospital, Cincinnati, Ohio, 1990-1998. Staff Physician, University Hospitals, Cleveland, Ohio, 1998-present. CONSULTING POSITIONS: Aventis, Cardiovascular Scientific Advisory Board, 1996-2001. Consultant, Cardiology, Brooke Army Medical Center, San Antonio, Texas, 1977-1989. Consultant, Southwest Research Institute, Department of Bioengineering, San Antonio, Texas,

1979-1992. Eli Lilly and Company, Cardiovascular Scientific Advisory Board, 1997-2001. Elsevier, Scientific Publishing Advisory Board, 2004-present. Millennium Pharmaceuticals, Inc., Cardiovascular Scientific Advisory Board, 1997-2001. Victor Chang Cardiovascular Research Institute, Scientific Advisory Board, Sydney, Australia

1996-present International Advisory Panel King Faisal Specialists Hospital & Research Centre 2008-present MEMBERSHIPS AND OFFICES IN PROFESSIONAL SOCIETIES: Alliance for Academic Internal Medicine, Board of Directors 2010-present Alpha Omega Alpha Honor Society, President, Georgetown Chapter American Association for the Advancement of Science American Federation for Clinical Research American Heart Association American Society For Clinical Investigation, Member American Society of Hypertension Association of American Physicians, Member Association of Professors of Cardiology, Counselor Association of Professors of Medicine, Board of Directors 2009-present Association of Professors of Medicine, Secretary-Treasurer 2009-present

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 4 Association of Professors of Medicine, President-Elect June 2010 Association of University Cardiologists Cardiac Muscle Society Central Society for Clinical Research, Counselor Fellow, American Physiological Society Fellow, American College of Cardiology Fellow, American College of Physicians-American Society of Internal Medicine Fellow, Council on Basic Cardiovascular Sciences, American Heart Association Fellow, Council on Clinical Cardiology, American Heart Association Fellow, Society of Cardiac Angiography Fellow, International Society for Heart Research Heart Failure Society of America, Founding Member, Executive Committee International Academy of Cardiovascular Sciences Board of Trustees New York Academy of Sciences San Antonio Cardiovascular Society (Co-Founder) Sigma XI Society for Cardiac Angiography & Intervention Program Committee Society for Cardiac Angiography and Intervention National Meeting Scientific Program Chairman Southern Society for Clinical Investigation HONORS AND AWARDS: BS Cum Laude, Georgetown University 1968 AOA National Medical Honor Society, President, Georgetown 1971 MD Magna Cum Laude - Valedictorian 1972 Kober Medal, Most Outstanding Graduate (1st in Class) 1972 Georgetown Medical School Henry Fordham Award, Outstanding Teacher 1975 University of North Carolina Medical School NIH Cardiovascular - Renal Study Section 1987-1991 Kaplan Lecture, University of Cincinnati 1990 NIH Cardiovascular - Renal Study Section Chairman 1990-1991 American Society For Clinical Investigation 1989 Who's Who in Health & Medical Services 1990 Who's Who in the World 1991 Who's Who in Medicine and Healthcare 1995 Who's Who in Science and Engineering 1993 University of Cincinnati Faculty Achievement Award 1994 Pfizer Visiting Professor, George Washington University, 1995, 1998, 2000 Wayne State University and Boston University AHA National Physiology and Pathophysiology 1995-1997 Study Section Chairman Association of American Physicians 1996 Langer Memorial Lecture, University of Pennsylvania 1996 Lyons Memorial Lecture, State University of New York Health 1997

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 5 Science Center, Syracuse, NY Distinguished Alumnus Award, Georgetown University Medical School 1997 White Lecture, Loyola University 1998 Hord Lecture, Case Western Reserve University 1999 George Brown Memorial Lecture, American Heart Association National Meeting 2000 Mikamo Lecture, Japanese Circulation Meeting 2001 Founder's Lecture, International Society for Heart Research 2001 International Game Fishing Association World Record 2001 NIH Lecture, Mayo Clinic 2002 Robert J. Glaser Clinical Star Visiting Professor, Washington University 2003 University of Cincinnati School of Medicine 2004 Commencement Address 2004 Senior Editor, Hurst’s the Heart 12th Edition 2005 Annual Robert Beamish Award, Intl. Academy of Cardiovascular Science 2006 Consumers’ Research Council of America “America’s Top Cardiologists” 2007 EDITORIAL BOARDS: Editor-In-Chief, Journal of Molecular and Cellular Cardiology, 1999-2008 American Heart Journal, 1989-2001 American Journal of Cardiology, 1985-2001 American Journal of Physiology: Heart and Circulatory Physiology, 1989-1993 American Journal of Physiology: Heart and Circulatory Physiology, 1995-1999 Cardiology Journal Club Journal, 1995-1998 Circulation, 1993-1999 Circulation Journal, 2002-present Circulation Research, 1992-1999 Circulation Research – Consulting Editor, 1999-2009 Congestive Heart Failure, 1995-2004 Hurst’s the Heart, McGraw-Hill publishers, 12th Edition. Senior Editor, Walsh RA, pp.

2477, 2008 Hurst’s the Heart, McGraw-Hill publishers, 13th Edition. Senior Editor, Walsh RA, in

press MANUSCRIPT REVIEWS: Abstract Reviewer: American Heart Association, American College of Cardiology American Federation for Clinical Research, Society for Cardiac

Angiography, International Society for Heart Research American Heart Journal American Journal of Cardiology American Journal of Physiology Annals of Internal Medicine Archives of Internal Medicine Catheterization and Cardiovascular Diagnosis Chest Circulation

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 6 Circulation Research Hypertension Journal of the American College of Cardiology Journal of Applied Physiology Journal of Physiology, London Journal of Clinical Investigation Journal of Molecular and Cellular Cardiology New England Journal of Medicine Proceedings of the National Academy of Science Science CERTIFICATION: Diplomate, National Board of Medical Examiners 1973 Diplomate, American Board of Internal Medicine (Medicine) 1975 Diplomate, American Board of Internal Medicine (Cardiology) 1977 LICENSURE: Active Ohio (#59382) January 1990 Inactive North Carolina Texas COMMITTEES: UTHSCSA School of Medicine Student Scholarship and Loan 1977-1980 Faculty Assembly Committee on Medical Center Hospital 1981-1984 Faculty Assembly Executive Committee 1982-1983 Laboratory Animal Resources Committee 1982-1983 Medical School Admissions Committee 1985-1987 Clinical Affairs Committee 1985-1989 UTHSCSA Department of Medicine Ad Hoc Committee Housestaff Training 1980-1982 Ad Hoc Committee UT Private Patient Service 1981-1983 Ad Hoc Committee on Housestaff Training 1986-1989 UT Medical Center Hospital Credentials Committee 1981-1984 Veterans Administration

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 7 Local: Research and Development Cardiopulmonary Section, Audie Murphy Veterans

Administration Hospital, San Antonio, Texas 1981-1984 Chairman, Research and Development Committee, Audie Murphy

Veterans Administration Hospital, San Antonio, Texas 1988-1989 Research and Development Committee, Audie Murphy Veterans

Administration Hospital, San Antonio, Texas 1987-1989 National: Research Career Development Committee, 1991-1995 University of Cincinnati College of Medicine Cardiology Focus Group, Chairman 1990-1993 Cardiovascular Research and Education Center, Chairman of Executive Committee 1990-1998 Dean's Departmental Review Committee, Member 1990-1997 Medical Sciences Scholars Committee (MD-PhD Program) 1990-1998 Chairman, Steering Committee, MD/PhD Program 1994-1998 Task Force on Future of Laboratory Animal Medicine 1990-1991 University Hospital Executive Committee of the Medical Staff 1991-1994 Department of Medicine Promotions and Tenure Committee 1992-1995 Department of Medicine Promotions and Tenure Committee, Chairman 9/93-5/95 Director of General Internal Medicine Search Committee, Chairman 1992-1993 Physiology Search Committee, Member 1993-1994 Pathology Search Committee, Member 1990-1991 Dean's Drake Academic Steering Committee, Member 1993-1998 Department of Medicine Space Committee, Member 1994-1998 University Hospital Budget Committee, Member 1994-1998 Children's Hospital, Director of Pediatric Cardiology Search Committee, Member 1995-1996 Pharmacology and Cell Biophysics Search Committee, Member 1995-1996 Medical Sciences Scholars Recruitment Committee (MD-PhD Program), Member 1995-1998 Self-Study Subcommittee on Medical School Departments: Basic Science, Member 1995-1997 Department of Medicine Research Office Task Force, Member 1996-1998 Alliance Heart Center Advisory Committee, Member 1996-1998 Transplantation Program Task Force, Member 1996-1997 Ohio Solid Organ Transplantation Consortium Board of Directors 1995-1997 Vice Chairman, Ohio Solid Organ Transplantation Consortium Board of Directors 1996-1997 Thesis Committees University of Cincinnati David Schultz Ph.D. Thesis Committee 1991-1992 Joe Palermo Ph.D. Thesis Committee 1992-1995 Christopher L. Taylor, Ph.D. Thesis Committee 1995-1996 Brett Abbott B.S., Thesis Advisor 1997-1998 Rajesh Dash B.S., Thesis Committee 1997-1998 Jing Zhai B.S., Thesis Committee 1997-1998 Deborah Rathz B.S., Thesis Advisor Case Western Reserve University and University Hospitals of Cleveland Case Medical Center Case Western Reserve University School of Medicine Executive Committee 1998-present

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 8 Department Committee on Appointments, Promotions and Tenure Howard Hughes Medical Institute, Biomedical Research Support Program, Advisory

Committee Chairman for the Search Committee for Chair, Department of Pathology 1998-1999 Ad Hoc Committee to Review Qualifications and Standards for Appointments, Promotions, and

Tenure for Faculty Members in the Case Western Reserve University School of Medicine 1998-2000

CWRU-University Hospitals Reaffiliation Committee 1998-2001 Steering Committee, Department of Physiology & Biostatistics 1998-present University Faculty Practice Association Executive Committee 1998-2007 University Hospitals Leadership Committee 1998-present University Faculty Practice Association Board of Directors 1999-2007 University Hospitals Faculty Service (Medical Service Organization) Board of Directors and

Executive Committee 1999-2007 University Hospitals Faculty Service President 2005-2007 University Hospitals Medical Group Board of Directors Standing Member 2008 Scientific Advisory Committee, Ireland Cancer Center 1999-present Advisory Committee, Medical Scientist Training Program (MD-PhD) 1999-present Intramural Executive Liaison Committee on Medical Education (LCME) 1999-2003 Advisory Board, Center for Biomedical Ethics 2000-present Geriatric Research, Education and Clinical Center (GRECC) Advisory Committee 2000-2003 General Clinical Research Center (GCRC) Advisory Committee 2002-present Chairman, Committee for Development of an Integrated Practice Plan 2003-2007 Dean’s Advisory Committee 2004-present University Hospitals of Cleveland President’s Advisory Council 2004-present Ireland Cancer Center Advisory Committee 2005-present President, University Faculty Practice Association Executive Committee 2005-2007 Chair, School of Medicine Committee to Revise Conflict of Interest and Commitment 2006-

2007 University Hospitals Health System Insurance Advisory Committee 2005-present University Hospitals Case Medical Center Medical Group Steering Committee 2005-present University President’s Committee for Evaluation of the School of Medicine 2007 Case Comprehensive Cancer Center Internal Advisory Executive Committee 2008-present UH Cancer Hospital Medical Executive Committee 2010-present Clinical Research Executive Committee 2010-present University Hospitals Health System Strategic Planning Task Force 2010-present

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 9 American Heart Association Local: President San Antonio Division 1985 Board of Directors San Antonio Division 1978-1989 Program Committee San Antonio Cardiology Society 1983-1985 Program Chairman Council VII 1984-1987 State: Program Committee Texas Affiliate 1986-1989 Central Research Committee Texas Affiliate 1986-1989 Texas Affiliate Board of Directors 1988-1989 Vice President Texas Affiliate 1989 Texas Affiliate Medical and Scientific Committee 1988-1989 Ohio Affiliate Research Steering Committee 1990-1995 Board of Directors Southwestern Ohio Area 1991-1994 Ohio Affiliate, Cincinnati Chapter Research Advisory Group 1990-1995 National: Council on Circulation, Executive Committee 1991-1998 Council on Circulation Program Committee, Member 1991-1998 Vice Chairman, Council on Circulation Program Committee 1997-1998 Chairman, Council on Circulation Program Committee 1998-1999 Council on Circulation Credentials Committee, Chairman 1991-1992

Council on Circulation Scientific Conference Planning Committee, Chairman 1991-1992

Scientific Conference on the Molecular Biology of the Normal, Hypertrophied and Failing Heart, Asilomar, California, Co-Director August 1993

Council on Circulation Budget Committee, Member 1993-1994 Council on Circulation Long Range Planning Committee, Member 1994-1998 Council on Circulation Nominating Committee, Member 1994-1998 Council on Circulation Marcus Selection Committee, Member 1994-1998 Cardiovascular Physiology and Pathophysiology Peer Review Committee,

Member 1993-1997 Cardiovascular Physiology and Pathophysiology Peer Review Committee,

Co-Chairperson 1994-1995 Cardiovascular Physiology and Pathophysiology Peer Review Committee,

Chairman 1995-1998 Intercouncil Task Force on Gene Therapy in Cardiovascular Disease,

Member 1994-1995 National Research Committee 7/1/95-6/30/2000 Cardiovascular Research Prize Selection Committee 1994-present Scientific Publishing Committee, Member 1998-present Council on Basic Cardiovascular Sciences Nominating Committee 2001-2003 Chairman, Scientific Publishing Committee 2001-2004 Board of Directors 2001-present Scientific Advisory Committee 2001-present

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 10 Conflict of Interest Review Committee, Member 2002-present Science Advisory Coordinating Committee, Member 2002-present Scientific Publishing Committee Chair 2002-2005 Association of Professors of Medicine Research Committee 2000-2006 Research Committee, Chair 2002-2006 Board of Directors 2000-2006 Board of Directors 2009-present Secretary-Treasurer 2009-present President-Elect June 2010 International Society for Heart Research International Society for Heart Research Program Committee, North American Section Annual Meeting, Cincinnati, Ohio International Society for Heart Research Scientific Program Advisory Committee, XVI World Congress, Rhodes, Greece Other Ohio Solid Organ Transplantation Consortium Board of Directors 1995-1997 National Scientific Advisory Committee of the Ad Hoc Group for Medical Research Funding

2000-present International Advisory Panel King Faisal Specialists Hospital & Research Centre 2008-present STUDY SECTIONS: American Heart Association AHA Texas Affiliate Central Research Committee 1987-1989 AHA Ohio Affiliate Central Research Committee 1990-1993 AHA National Cardiovascular Physiology and Pathophysiology Study Section, Chairman 1994-

1996 National Institutes of Health NIH Study Section Ischemic SCORS 1986 NIH Cardiovascular Study Section B 1987-1991 NIH Cardiovascular Study Section B Chairman 1989-1991 NIH National Health Reviewers Reserve (NRR) 1991-present NIH Ad Hoc Reviewers Research Training Program Section 1992 NIH Special Emphasis Panel on Research in Heart Failure 1996 NIH Special Emphasis Panel on Integrated Cardiovascular Research 1996 NIH Special Emphasis Panel on Cardiovascular Effects of Aging 1997 NIH Special Study Section on Heart Failure RFA Chairman 1998

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 11 Veterans Administration Veterans Administration Cardiopulmonary Research Committee, San Antonio, Texas 1981-

1984 Veterans Administration Research and Development, San Antonio, Texas 1987-1989 Veterans Administration National Research Career Development Committee 1991-1997 Veterans Administration Dean’s Advisory Committee 1998-present

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 15 EXTRAMURAL INVITED LECTURES: (Selected Examples) Named Lectureships: Plenary Lecture, 61st Annual Scientific Sessions, American Heart Association, Washington, DC, November 1988 "Role of the Calcium Antagonists in the Management of Heart Failure" Annual Kaplan Lecture, University of Cincinnati Pediatric Cardiology Cincinnati, OH, June 1990 "Pressure Overload Hypertrophy: Molecular Biologic Similarities to Cardiac

Development” Alpha Omega Alpha Annual Award Banquet, Keynote Address Cincinnati, OH, May 1991 "Why You Should Consider A Career in Academic Medicine" College of Medicine Reunion '91 Scientific Session, University of Cincinnati College of Medicine, Cincinnati, OH, May 1991 "UC Cardiovascular Research & Education Center" University of Cincinnati Class of 1995, Keynote Address Cincinnati, OH, August 1992 "The Transition Between Basic Science and Clinical Years in Medical Student

Education" University of Cincinnati Emeriti Faculty Symposium, Successful Aging: Preventive

Gerontology, Heart Disease, Cincinnati, OH, October 1992 "Advances in Prevention and Treatment" Plenary Session XIII Symposium: 67th Annual Scientific Sessions Dallas, TX, November 1994 "Progression to Clinical Heart Failure, Pressure Overload" Plenary Lecture, 44th Annual Scientific Sessions, American College of Cardiology New Orleans, LA, March 1995 Clinical Mechanisms of Cardiovascular Disease: From Pathophysiologic Concepts to the Bedside of the Patient, "What Molecular and Biochemical

Events are Important in the Progression of Heart Failure?" Pfizer Visiting Professorship Program in Cardiovascular Medicine, Medical Grand

Rounds and Cardiology Grand Rounds Georgetown University, Washington, DC, April 1995 "Challenges and Opportunities in the Treatment of Heart Failure 1995" and "Biochemical Events are Important in the Progression of Heart Failure" Langer Memorial Lecture, University of Pennsylvania School of Medicine Philadelphia, PA, October 1996 "Molecular Mechanisms for the Transition Between Cardiac Hypertrophy and Failure" Richard H. Lyons Memorial Lecture, Medical Grand Rounds State University of New York Health Science Center, Syracuse, NY, November 1997 "Diastolic Heart Failure: What is it? How do you Treat it?" Edward J. and Eileen D. Prendergast White Memorial Lecture, Loyola University

Chicago, Maywood, IL, May 1998

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 16 "Molecular Mechanisms of Heart Failure: New Developments" John H. Hord Professorship Lecture, Case Western Reserve University Cleveland, OH, April 1999 “Molecular Mechanisms for Heart Failure: The Role of Protein Kinase C Activation” Pfizer Visiting Professorship in Cardiovascular Medicine, Medical Grand Rounds and Cardiology Grand Rounds Wayne State University, Detroit, MI, August 1999 “Management of Congestive Heart Failure 1999” “Molecular Mechanisms for Heart Failure – The Role of Altered PKC Activation”

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 17

Pfizer Visiting Professorship in Cardiovascular Medicine, Medical Grand Rounds and Cardiology Grand Rounds Boston University, Boston, MA, February 2000 “Bridging the Gap Between Molecular Biology and Physiology in Treating Heart

Failure Patients” “New Perspectives on the Treatment of Heart Failure” George Brown Memorial Lecture, American Heart Association, 73rd Annual Scientific

Session, New Orleans, LA, November 2000 "Protein Kinase C Activation in Cardiac Hypertrophy and Failure: Lessons From Mice

and Men" Mikamo Lecture, 65th Annual Scientific Meeting, Japanese Circulation Society, Kyoto University, School of Medicine, Kyoto, Japan, March 2001 “Molecular Mechanisms for Heart Failure” Founder's Lecture, International Society for Heart Research, Winnipeg, Manitoba, Canada,

July 2001 "The Role of Protein Kinase C in the Development of Cardiac Hypertrophy and

Failure" Dean’s Annual Visiting Professor University of Puerto Rico, School of Medicine, October 2003 “Molecular and Cellular Mechanisms for Heart Failure” Robert J. Glaser Visiting Professor Washington University, St. Louis, MO October 2003 University of Cincinnati School of Medicine 2004 Commencement Address, May 2004 PARTICIPATION IN NATIONAL SCIENTIFIC MEETINGS (SELECTED) RECENT American Heart Association 59th Annual Scientific Sessions, Dallas, TX, November, 1986 1. Chairman, Postgraduate Seminar, Determinants of LV Diastolic Function 61st Annual Scientific Sessions, Washington, DC, November 1988 1. Plenary Session, Role of the Calcium Antagonists in the Management of Heart Failure 2. Invited Lecture, Cardiovascular Conference, Left Ventricular Diastolic Dysfunction 64th Annual Scientific Sessions, Anaheim, CA, November 1991 1. Chairman, Postgraduate Seminar, Mechanisms of Altered Ventricular Function in

Pressure-Overload Hypertrophy 2. Invited Lecture, Postgraduate Seminar, Contractile Proteins

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 18 Scientific Conference on the Molecular Biology of the Normal, Hypertrophied and Failing Heart Asilomar Conference Center, Pacific Grove, CA, August 1993 1. Conference Co-Chairman 2. Pressure Overload Hypertrophy and Heart Failure in the Guinea Pig 67th Annual Scientific Sessions, Dallas, TX, November 1994 1. Plenary Session XIII Symposium: Progression to Clinical Heart Failure, Pressure

Overload 68th Annual Scientific Sessions, Anaheim, CA, November 1995 1. Program 11, The Promise of Molecular Cardiology: New Insights in Cardiovascular

Disease from Molecular Biology: Insight Into Cardiac Dysfunction From Studies in Transgenic Mice

2. Cardiovascular Seminar 18, Councils on Clinical Cardiology and High Blood Pressure Research: Heart Failure as a Consequence of LVH

69th Annual Scientific Sessions, New Orleans, LA, November 1996 1. Cardiovascular Seminar, Councils on Circulation and Cardiopulmonary and Critical

Care: Regulation of Cardiac Contractility: Potential Implications for the Failing Heart 2. Featured Research, Molecular Tools and Ventricular Function: State-of-the-Art:

Ventricular Function in Gene Targeted and Transgenic Mice: A Hierarchical Approach

3. Frontiers in Basic Research, Cardiac Function in Genetically Engineered Mice 71st Annual Scientific Sessions, Dallas, TX, November 1998 1. Cardiovascular Seminar, PKC Signaling in CV Development and Disease: PKC

Mediated Hypertrophy and Contractile Failure Scientific Conference on Molecular, Cellular, and Integrated Physiological Approaches to the Failing Heart, August 1999 1. PKC Signaling in the Heart 72nd Annual Scientific Sessions, Atlanta, GA, November 1999 1. Co-Chair, What Genetic Engineering In Vivo Has Taught Us 2. Invited Lecture, Protein Kinases and Phosphatases in Cardiac Hypertrophy and Heart

Failure, PKC 3. Moderator, Cardiac Function in Murine Genetic Models 73rd Annual Scientific Sessions, New Orleans, LA, November 2000 1. George E. Brown Lecture, Protein Kinase C Activation in Cardiac Hypertrophy and

Failure: Lessons From Mice and Men 75th Annual Scientific Sessions, Chicago, IL, November 2002 1. How to Publish in an AHA Journal: Editor Perspectives on Current Issues in the

Biomedical Peer-Reviewed Literature

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 19

2. Apoptosis in Experimental Cardiac Ischemia and Infarction 76th Annual Scientific Sessions, Orlando, FL November 2003

1. How to Publish in an AHA Journal 2. Invited Lecture, Novel Gene Therapies 3. Moderator, Introduction to Scientific Sessions 2003, Basic Science

American College of Cardiology (Selected) Recent 31st Annual Scientific Sessions, Atlanta, GA, April 1982 1. Invited Lecture, Diagnosis and Management of Acute Aortic Regurgitation 33rd Annual Scientific Sessions, Dallas, TX, March 1984 1. Invited Lecture, CA++ Channel Blockers, March 1984 35th Annual Scientific Sessions, Atlanta, GA, March 1986 1. Invited Lecture, Cardiovascular Effects of the Aging Process 2. Invited Lecture, Unstable Angina 3. Invited Lecture, Special Problems in Elderly Patients with ischemic Heart Disease 40th Annual Scientific Sessions, Atlanta, GA, March 1991 1. Core Curriculum, Effects of Calcium Channel Blockers on Diastolic Function 44th Annual Scientific Sessions, American College of Cardiology, New Orleans, LA, March 1995 1. Plenary Lecture, Clinical Mechanisms of Cardiovascular Disease: From

Pathophysiologic Concepts to the Bedside of the Patient, What Molecular and Biochemical Events are Important in the Progression of Heart Failure?

47th Annual Scientific Sessions, Atlanta, GA, March 1998 1. Co-Chair, Adrenergic Receptors and Cardiac Function 2. Co-Chair, Molecular Mechanism of Heart Failure 51st Annual Scientific Sessions, Atlanta, GA, March 2002

1. Invited Lecture, Abnormal Signal Transduction Pathways

Advisory Group on Myocardial Ischemia and Infarction Boston, MA, August 1991 1. Systolic and Diastolic Dysfunction Post-Myocardial Infarction

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 20 The American College of Clinical Pharmacy 12th Annual Meeting, Minneapolis, MN, August 1991 1. Invited Lecture, Management of Left Ventricular Diastolic Dysfunction The American Society of Hypertension 14th Scientific Meeting, New York, NY, May 1999 1. Invited Lecture, Mechanisms for Cardiac Hypertrophy and Failure: A Transgenic

Approach Georgetown University Graduate Public Policy Program Washington, DC, June 1993 1. Invited Lecture, Health Care Reform Panel with Ira Magaziener The George Washington University Washington, DC, April 1995 1. Pfizer Visiting Professor, Medical Grand Rounds, Challenges and Opportunities in the

Treatment of Heart Failure 1995 2. Pfizer Visiting Professor, Cardiology Grand Rounds, Molecular Mechanisms for the

Transition Between Compensated Hypertrophy and Heart Failure The Heart Failure Society San Francisco, CA, September 1999

1. Third Scientific Meeting, PKC Pathways Boca Raton, FL, September 2000 1. Fourth Scientific Meeting, LVH Regression: What Does it Mean for the Prevention of

Heart Failure Boca Raton, FL, September 2002

1. Sixth Scientific Meeting, Signaling in Heart Failure: Cytokines, Kinases and Other Mediators

PARTICIPATION IN INTERNATIONAL MEETINGS (Selected)

1. Laboratoire INSERM, Effects of CA++ Channel Blockers on LV Function, Montpellier,

France, December 1982 2. Laboratoire INSERM, Pressure Overload Hypertrophy: Functional and Biochemical

Relations, Montpellier, France, September 1988 3. Interamerican Congress on Hypertension, Calcium Antagonists in Ischemic Heart Disease,

San Juan, Puerto Rico, May 1989 4. Puerto Rico and Venezuelan Heart Association Combined Meeting, New Approaches to

Congestive Heart Failure, Caracas, Venezuela, June 1989

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 21 5. A Decade of Experience: An International Summit on Diltiazem HCL, The Effects of

Calcium Channel Blockers on Left Ventricular Function, The Hague, Netherlands, May 1991

6. International Society for Heart Research, North American Section, Annual Meeting,

Cardiac Myosin Heavy- and Light-Chain Gene Expression in Hypertrophy and Heart Failure, Cincinnati, OH, May/June 1991

7. Chairman, International Symposium on the Physiology of Diastole in Health and Disease:

Impaired Relaxation in Experimental Models: Hypertrophy and Failure, Beth Israel Hospital, Harvard Medical School, Palm Springs, FL, January, 1993

8. Symposium 8: Cardiomyopathy, Co-Chairman, International Society for Heart Research,

American Section, XV Annual Scientific Sessions, University of Missouri, Columbia, MO, June 1993

9. Symposium 8: Cardiomyopathy, Altered Contractile Proteins, International Society for

Heart Research, American Section, XV Annual Scientific Sessions, University of Missouri, Columbia, MO, June 1993

10. The XV World Congress of the International Society for Heart Research Symposium on

Structural, Molecular and Mechanistic Alterations Underlying Heart Failure, Molecular Mechanisms for the Transition Between Compensated Hypertrophy and Heart Failure, Prague, Czech Republic, July 1995

11. Crossroads in Medicine Debrecen 1995, Regulation of Myocardial Contractility: New

Concepts and Their Clinical Applications Session, Treatment of Cardiac Failure in 1995, University Medical School of Debrecen, Debrecen, Hungary, July 1995

12. IV World Congress of the International Society for Adaptive Medicine. Molecular

Mechanisms for the Transition Between Compensated Cardiac Hypertrophy and Heart Failure, Chandigarh, India, December 1995

13. University of Madras Department of Physiology. Heart Failure, Madras, India, December

1995 14. Calcium Channel Blockers in the Treatment of Cardiovascular Disease. The Sound, the

Fury and the Facts. University Medical School Debrecen, Debrecen, Hungary, March 1996

15. International Society for Heart Research, American Section, Annual Meeting. Heart

Failure: Controversies and Mechanisms, Chicago, IL, June 1996

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 22 16. Cardiomyopathy and Heart Failure Summit: From Pathophysiology to Clinical Practice.

Impact of Stretch Signal Transduction in the Failing Myocyte, Toronto, Ontario, Canada, June 1996

17. Visiting Professor, Pharmacologic Treatment of Congestive Heart Failure 1996: The U.S.

Experience. Chinese Academy of Medicine, Tianjin Heart Institute, Tianjin, China, September 1996

18. Visiting Professor, Molecular Mechanisms for Heart Failure. Chinese Academy of

Medicine, Tianjin Heart Institute, Tianjin, China, September 1996 19. Visiting Professor, Cardiovascular Forum on Angiotensin II Receptor Blockade. The

Role of Angiotensin II in Modulating Cardiac Function: Molecular Mechanisms of Regulation. University of Manitoba, Winnipeg, Canada, October 1996

20. International Society for Heart Research XVIII European Section Meeting. Cellular and

Molecular Mechanisms of Heart Failure. Mechanotransduction in the Normal, Hypertrophied, and Failing Adult Heart. Versailles, France, July 1997

21. Visiting Professor, Heart Research Lecture Series, Signal Transduction, Cardiac

Hypertrophy and Heart Failure. The Rayne Institute, St. Thomas' Hospital, London, England, July 1997

22. Invited speaker, The Role of Angiotensin II in Stretch Activated Signal Transduction of

the Normal, Hypertrophied and Failing Adult Heart. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Center, University of Manitoba, Winnipeg, Manitoba, Canada, September 1997

23. Invited speaker, XVI Interamerican Congress of Cardiology, VIII Puerto Rican Congress

of Cardiology. Assessment of Cardiovascular Function in Health and Disease, San Juan, Puerto Rico, September 1997

24. Invited speaker, XVI Interamerican Congress of Cardiology, VIII Puerto Rican Congress

of Cardiology. Left Ventricular Diastolic Dysfunction, San Juan, Puerto Rico, September 1997

25. Invited speaker, First Scientific Meeting of Japanese Heart Failure Society. Molecular

Mechanisms for the Transition Between Cardiac Hypertrophy and Heart Failure, Sakyo-ku, Kyoto, Japan, September 1997

26. Plenary speaker, First Scientific Meeting of Japanese Heart Failure Society, Satellite

Symposium. Molecular Mechanisms for Heart Failure, Sakyo-ku, Kyoto, Japan, September 1997

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 23 27. Invited speaker, PKC Mediated Signal Transduction in the Normal, Hypertrophied, and

Failing Heart. Yamagata University School of Medicine, Yamagata, Japan, October 1997 28. Invited speaker, Molecular Mechanisms for Congestive Heart Failure. Yamagata

University School of Medicine, Yamagata, Japan, October 1997 29. Invited speaker, International Symposium on Heart Disease. The Role of Protein Kinase C

in Cardiac Hypertrophy and Heart Failure. Cairo, Egypt, May 1998 30. Invited speaker, VI Meeting of the International Society for Heart Research Latin

American Section. The Role of Protein Kinase C in Left Ventricular Hypertrophy and Heart Failure. Buenos Aires, Argentina, May 1999.

31. Invited speaker, VI Meeting of the International Society for Heart Research Latin

American Section. Left Ventricular Hypertrophy and Heart Failure. Buenos Aires, Argentina, May 1999.

32. Invited speaker, The 7th Antwerp-La Jolla-Kyoto Research Conference on Cardiac

Function. New Therapeutic Targets: Myocardial Subcellular Signaling Cascades. Kyoto, Japan, February 2000.

33. Invited speaker, The 7th Antwerp-La Jolla-Kyoto Research Conference on Cardiac

Function. Signaling Mechanisms in Cardiac Hypertrophy and Failure: Where are we and where are we going? Kyoto, Japan, February 2000.

34. Invited speaker, XXII Annual Scientific Session, International Society for Heart Research,

American Section. The role of PKC in the Development of Hypertrophy. Louisville, KY, June 2000.

35. Invited speaker, XXII Annual Scientific Session, International Society for Heart Research,

American Section. Isolated Myocyte Mechanics and Calcium Transients. Louisville, KY, June 2000.

36. Invited speaker, Joint meeting of the Scandinavian Physiological Society and the

American Physiological Society. Regulation of Cardiac Contractility. Stockholm, Sweden, August 2000.

37. Invited speaker, 10th International Congress on Cardiovascular Pharmacotherapy.

Molecular Mechanisms for Cardiac Hypertrophy and Regression. Kyoto, Japan, March 2001.

38. Invited speaker, XVIIth World Congress of the International Society for Heart Research.

The Role of Protein Kinase C in the Development of Cardiac Hypertrophy and Failure. Winnipeg, Manitoba, Canada, July 2001

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 24 39. Moderator, 24th Annual Meeting of the International Society for Heart Research, North

American Section. Signaling in Hypertrophy and Heart Failure. Madison, WI, July 2002 40. Invited speaker, 19th International Society for Heart Research, Japanese Section and

International Society for Heart Research Satellite Symposium. Molecular Mechanisms for Cardiac Hypertrophy and Heart Failure: Are They the Same; Current Therapy of Congestive Heart Failure in the United States. Yamagata, Japan, October 2002

41. Invited speaker, Victor Chang Research Institute. Molecular Mechanisms for Cardiac

Hypertrophy and Failure: Where Are We? Sydney, Australia, March 2004 42. Invited speaker, 26th International Society for Heart Research, American Section.

Molecular and Cellular Mechanisms for Cardiac Hypertrophy and Failure. Cancun, Mexico, May 2004

43. Invited speaker, 38th Lake Kawaguchi Conference on Cardiology. Molecular Mechanisms

for Cardiac Hypertrophy and Failure: New Therapeutic Opportunities. Tokyo, Japan, July 2004

44. Invited speaker, XVIIIth World Congress of the International Society for Heart Research.

Molecular and Cellular Mechanisms for Cardiac Hypertrophy and Failure. Brisbane, Australia, August 2004

45. Invited speaker, European Section ISHR Tromso Norway June 2005 46. Invited speaker, XXXI Portuguese Society of Cardiology. From Molecular Biology to

Clinical Cardiology. Lisbon, Portugal, April 2011 REGIONAL CONFERENCES AND SYMPOSIA (Selected) 1. Cardiac Diagnosis from the Physical Examination, Heart House, Washington, DC,

February 1982 2. Course Co-Director, Cardiology Update for the Practicing Physician, sponsored by The

University of Texas Health Science Center CME, San Antonio, TX, April 1983 3. Visiting Professor, Puerto Rico Heart Association and University of Puerto Rico, San

Juan, Puerto Rico, September 1985 4. Satellite Symposium on Modulation of the Sympathetic Nervous System in Congestive

Heart Failure, American College of Cardiology, Atlanta, GA, March 1988 5. Scientific Conference on Myocardial Hypertrophy, American Heart Association, Big Sky,

WY July 1988

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 25 6. Diastolic Heart Failure-Pathophysiology and Treatment, Puerto Rico Congress of

Cardiology, San Juan, Puerto Rico, April 1991 7. Regression of Left Ventricular Hypertrophy: Good, Bad or Indifferent, V Puerto Rico

Congress of Cardiology, San Juan, Puerto Rico, April 1991 8. San Diego Academy of Family Physicians 35th Annual Postgraduate Symposium,

Cardiovascular Diseases in the Elderly, San Diego, CA, July 1991 9. Diastolic Heart Failure, Central New York Academy of Medicine, Utica, NY, October

1991 10. Midwest Clinical-Molecular Cardiology Conference, Saint Louis University School of

Medicine, Cardiomyopathy Molecular Considerations, Saint Louis, MO, October 1992 11. Systolic and Diastolic Dysfunction, 44th Annual Heart Day, Central New York Academy

of Medicine, Utica, NY, October 1993 12. The Changing World of Cardiology: Medical Update and Survival Guide to the Future,

Pennsylvania Chapter, American College of Cardiology Regional Meeting, White Sulphur Springs, WV, December 1993

13. Controversies in the Management of Heart Failure, Florida Chapter, American College of

Cardiology, Orlando, FL, September 1994 14. New Dimensions in Cardiology Symposium, Congestive Heart Failure - New Approaches

to a Growing Problem. The Dayton Heart Center, Dayton, OH, October 1995 15. State-of-the Art Coronary Artery Disease II, Molecular Mechanisms for the Transition

Between Cardiac Hypertrophy and Heart Failure, Central Society for Clinical Research Midwestern Meeting, Chicago, IL, October 1995

16. Cardiology Update 1996, Controversies in the Management of Congestive Heart Failure.

Sponsored by The University of Texas Health Science Center CME, San Antonio, TX, February 1996

17. Molecular Mechanisms for the Transition Between Hypertrophy and Heart Failure. Eli

Lilly and Company Corporate Center, Indianapolis, IN, July 1996 18. Cardiology Fiesta in San Antonio: Update on Cardiac Diagnostic and Therapeutic

Techniques, Differentiation of Pathologic vs. Physiologic LVH. Sponsored by the American College of Cardiology in cooperation with The University of Texas Health Science Center at San Antonio, San Antonio, TX, April 1997

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 26 19. Bold New Era for Cardiovascular Research Conference, Genetic Basis of Heart Failure.

Co-sponsored by Boston University School of Medicine and American Heart Association, Boston MA, May 1998

20. Antiotensin-mediated Phospholipase C Activation in Cardiac Hypertrophy and Failure.

Experimental Biology ’99. Joint meeting of the APS, ASPEt and ASIP, Washington, DC, April 1999

21. 24th Annual Update: Cardiology for the Primary Physician. Co-sponsored by Medical

University of South Carolina and American College of Cardiology, June 2000 22. Cardiology Fiesta in San Antonio: Update on Cardiac Diagnostic and Therapeutic

Techniques, Differentiation of Pathologic vs. Physiologic LVH. Sponsored by the American College of Cardiology in cooperation with The University of Texas Health Science Center at San Antonio, San Antonio, TX, April 2002

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 27 LECTURES: ACADEMIC MEDICAL CENTERS AND MEDICAL SOCIETIES

(Selected) 1. American Medical Association, Symposium on Coronary Artery Disease, San Antonio

Division, San Antonio, TX, January 1980 2. American Heart Association, Symposium on Coronary Artery Disease, San Antonio

Division, San Antonio, TX, February 1981 3. Hahnemann Medical School Symposium, CA++ Channel Blockers, Philadelphia, PA,

September 1982 4. Symposium on CA++ Channel Blockers, University of Florida, Gainesville, FL, May 1983 5. Visiting Professor, Montreal Heart Institute and McGill University Faculty of Medicine,

Montreal, Quebec, Canada, June 1984 6. Visiting Professor, University of Iowa, Iowa City, IA, February 1985 7. Medical Grand Rounds, Georgetown University, Washington, DC, April 1986 8. Medical Management of Ischemic Heart Disease: Combination Therapy in the Treatment

of Angina, Baylor College of Medicine, Houston, TX 1986 9. Visiting Professor, University of Michigan, Ann Arbor, MI, September 1986 10. Visiting Professor, Case Western Reserve University, Cleveland, OH, January 1987 11. Long-Term Management of Survivors of Myocardial Infarction, Robert Wood Johnson

Medical School, Piscataway, NJ, May 1987 12. Medical Grand Rounds, University of British Columbia, Vancouver, BC, August 1987 13. Visiting Professor, Presbyterian University of Pennsylvania, Philadelphia, Pennsylvania,

December 1987 14. Visiting Professor, University of Miami, Mt. Sinai Hospital, Miami FL, July 1988 15. Medical Grand Rounds, Medical College of Virginia, Richmond, VA, November 1988 16. Medical Grand Rounds, University of Tennessee, Knoxville, TN May 1989 17. Visiting Professor, Vanderbilt University, Nashville, TN, May 1989

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 28 18. Visiting Professor, Pressure Overload Hypertrophy in the Nonhuman Primate, St. Louis

University, St. Louis, MO, August 1989 19. Visiting Professor, University of Cincinnati, Cincinnati, OH August 1989 20. Division of Cardiology, University of Chicago & Michael Reese Hospital, Chicago, IL,

October 1989 21. Medical Grand Rounds, University of Massachusetts, Worcester, MA, February 1990 22. Visiting Professor, Per Lunheim University of Trondheim, Department of Cardiology,

Trondheim, Norway, March 1990 23. Division of Cardiology, George Washington University, Washington, DC, May 1990 24. Medical Grand Rounds, Good Samaritan Hospital, Cincinnati, OH, July 1990 25. Medical Grand Rounds, University of Cincinnati, OH, July 1990 26. Division of Cardiology, University of Rochester, Rochester, NY, October 1990 27. Division of Cardiology, Medical College of Virginia, Richmond, VA, November 1990 28. Medical Grand Rounds, Differential Effects of Calcium Blockers and Vasodilators on LV

Function, University of Washington, Olympia, WA, April 1991 29. Assessment of Contractility and Relaxation in the Intact Heart, Children's Hospital

Medical Center, Cincinnati, OH, April 1991 30. Pressure Overload Hypertrophy-Cardiac Mechanical and Molecular Relations, The

Cleveland Clinic Foundation, Cleveland, OH, April 1991 31. Visiting Professor, Bayamon Regional Hospital, San Juan, Puerto Rico, April 1991 32. Course Director, Cardiology Update for the primary Practitioner, University of Cincinnati

Medical Center, Cincinnati, OH, April 1991 33. Anatomy and Cell Biology Department Seminar, Hypertension and Hypertrophy,

University of Cincinnati, Cincinnati, OH, May 1991 34. Medicine Morbidity & Mortality Conference, Acute Mitral Regurgitation, Veterans

Administration Medical Center, Cincinnati, OH, July 1991 35. Medical Grand Rounds, Diastolic Heart Failure: Pathophysiology and Treatment,

University of Cincinnati, Cincinnati, OH, July 1991

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 29 36. Pressure Overload Hypertrophy: Molecular, Biochemical and Mechanical Relations, The

University of Alabama, Birmingham, AL, October 1991 37. Medical Grand Rounds, Diastolic Heart Failure: Etiology, Pathophysiology and

Management, University of Florida, Gainesville, FL, December 1991 38. Cardiology Grand Rounds, Pressure-Overload Hypertrophy: Cardiac Biochemical and

Mechanical Relations, University of Florida, Gainesville, FL, December 1991 39. Medical Grand Rounds, Controversies in the Management of CHF Due To Systolic

Dysfunction, National Cheng Kung University Medical College, Tainan, Taiwan, Republic of China, February 1992

40. Medical Grand Rounds, Diastolic Heart Failure, Chang Gung Memorial Hospital,

Kaohsiung Hsien, Taiwan, Republic of China, February 1992 41. Cardiology Research Conference, Ventricular Hypertrophy: Myosin Heavy- and Light-

Chain Alterations, Chang Gung Memorial Hospital, Kaohsiung Hsien, Taiwan, Republic of China, February 1992

42. Medical Grand Rounds, Diastolic Heart Failure, University of Vermont, Burlington, VT,

March 1992 43. Cardiology Research Seminar, Myosin Heavy- and Light-Chain Gene Regulation in

Pressure Overload Hypertrophy, University of Vermont, Burlington, VT, March 1992 44. Medical Grand Rounds, Controversies in the Treatment of Heart Failure: Old and New,

Lexington, University of Kentucky Medical Center, KY, October 1992 45. Medical Grand Rounds, Controversies in Managing CHF: Old and New, The University

of Kansas, Wichita, KS, November 1992 46. Department of Pharmacology and Cell Biophysics Graduate Student Seminar, Molecular

Aspects of Heart Failure, University of Cincinnati, Cincinnati, OH, November 1992 47. Chief Medical Residents Meet the Professor Symposium: Controversies in the Treatment

of Congestive Heart Failure, University of Maryland, Hyannis, MA, October 1993 48. Cardiology Grand Rounds, Controversies in the Management of Congestive Heart Failure,

Holzer Clinic, Gallipolis, OH, January 1994 49. Medical Grand Rounds, In Search of Molecular Mechanisms for Congestive Heart

Failure, University of Cincinnati, Cincinnati, OH, January 1994 50. Medical Grand Rounds, In Search of Molecular Mechanisms for Heart Failure, Ochsner

Heart and Vascular Institute, New Orleans, LA, February 1994

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 30 51. Cardiology Grand Rounds, Controversies in the Medical Management of Systolic and

Diastolic Heart Failure, Ochsner Heart and Vascular Institute, New Orleans, LA, February 1994

52. Medical Grand Rounds, The Transition Between Cardiac Hypertrophy and Heart Failure,

Tufts University, St. Elizabeth's Medical Center, Boston, MA, June 1994 53. Clinicopathologic Conference, Department of Internal Medicine, University of Cincinnati,

Cincinnati, OH, August 1994 54. Cardiology Research Conference, The Transition Between Compensated Cardiac

Hypertrophy and Failure: Mechanics and Mechanisms, University of Pittsburgh, Pittsburgh, PA, September 1994

55. Cardiology Grand Rounds, Hahnemann University, Allegheny General Hospital,

Pittsburgh, PA, September 1994 56. Medical Pharmacology Graduate Student Lecture, Treatment of Congestive Heart Failure,

University of Cincinnati College of Medicine Cincinnati, OH, January 1995 57. Physiology Graduate Student Lecture, Myocardial Ischemia, University of Cincinnati

College of Medicine Cincinnati, OH, February 1995 58. Medical Grand Rounds, Challenges and Opportunities in the Treatment of Congestive

Heart Failure, University of Cincinnati, Cincinnati, OH, February 1995 59. Pathobiology and Molecular Medicine Graduate Student Lecture, Myocardial Growth and

Hypertension, University of Cincinnati, Cincinnati, OH, February 1995 60. Cardiology Grand Rounds, Molecular Mechanisms for the Transition Between Cardiac

Hypertrophy and Failure, University of Virginia Health Sciences Center, Charlottesville, VA, March 1995

61. Cardiology Research Seminar, Molecular Mechanisms Involved in the Transition

Between Pressure Overload Hypertrophy and Heart Failure, University of Chicago, Chicago, IL, June 1995

62. Medical Grand Rounds, New Developments in the Management of Congestive Heart

Failure - 1995, The University of Alabama, Birmingham, AL, August 1995 63. Cardiology Grand Rounds, Molecular Mechanism for the Transition Between Cardiac

Hypertrophy and Heart Failure, The University of Alabama, Birmingham, AL, August 1995

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 31 64. Medical Grand Rounds and Cardiology Research Seminar, New Developments in the

Management of Congestive Heart Failure and Molecular Mechanics for the Transition Between Cardiac Hypertrophy and Heart Failure, The University of Texas Health Science Center, San Antonio, TX, August 1995

65. Animal Models of Cardiac Dysfunction Symposium, Molecular Mechanisms for the

Transition Between Hypertrophy and Failure, University of Minnesota, Minneapolis, MN, September 1995

66. Coronary Artery Disease-Prevention and Treatment. Looking Toward the 21st Century,

accredited by the Pennsylvania Medical Society, Harrisburg, PA, May 1996 67. Cardiovascular Medicine at the Crossroads. New Technology in the Era of Managed

Care, accredited by The Christ Hospital, Cincinnati, OH, May 1996 68. Medical Grand Rounds, Diastolic Heart Failure: Mechanisms and Treatment, University

of Cincinnati College of Medicine, Cincinnati, OH, July 1996 69. Cardiology Grand Rounds, Molecular Mechanisms for the Transition Between Cardiac

Hypertrophy and Failure, Baylor College of Medicine, Houston, TX, December 1996 70. Invited speaker, Association of University Cardiologists Thirty-sixth Annual Meeting,

Mechanotransduction in the Normal, Hypertrophied, and Failing Adult Heart, Carmel, CA, January 1997

71. Congestive Heart Failure in the Primary Care Setting, Challenges in the Treatment of

Systolic and Diastolic Heart Failure, University of Cincinnati College of Medicine, Cincinnati, OH, May 1997

72. Invited speaker, Institut National de la Sante et de la Recherche Medicale, INSERM U.

Altered Phospholipase C Signal Transduction in Heart Failure: an Animal Model Transgenic and Clinical Analysis, Creteil Cedex, France, July 1997

73. Invited speaker, 1st Scientific Meeting, Heart Failure Society of America. Physiologic

Abnormalities and Cardiac Dysfunction in Transgenic Mouse Models, Baltimore, MD, September 1997

74. Invited speaker, New York Academy of Sciences Conference on Cardiac Sarcoplasmic

Reticulum Function and Regulation of Contractility, Molecular Mechanisms for Heart Failure: Current Concepts and Future Directions for Therapy, Washington, D.C., September 1997

75. Cardiology Grand Rounds, The Role of Phospholipase C Activation in Experimental and

Human Heart Failure, Massachusetts General Hospital, Cardiovascular Research Center, Charlestown, MA, January 1998

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 32 76. Cardiology Grand Rounds, Molecular Mechanisms for Heart Failure - The role of Protein

Kinase C, University of Louisville Health Sciences Center, Louisville, KY, March 1998 77. Invited speaker, Collaborative Cardiovascular Research Conference, Phospholipase C

Activation in Hypertrophy and Heart Failure: Lessons from Mice and Men, University of Pittsburgh School of Medicine and Allegheny University of Health Sciences, May 1998

78. Invited Speaker, Heart Failure in Our Community: A Call for Improved Standards of

Care Conference, Management of Diastolic Heart Failure, University of Cincinnati School of Medicine, June 1998

79. Molecular Mechanisms for Heart Failure: The Role of Protein Kinase C Activation, The

Cleveland Clinic Foundation, March 1999 80. Molecular Mechanisms for Heart Failure – New Directions for Therapy, MetroHealth

Medical Center, Cleveland, OH, May 1999 81. Medicine Grand Rounds, Case Western Reserve University, Cleveland, OH, August 2000 82. 2001 Mercy Health Partners Endowed Visiting Professor of Medicine, Toledo, OH, April

2001 83. Invited Speaker, American Diabetes Association 61st Scientific Session: Role of PKC

Modulators to Preserve Cardiac Function, Philadelphia, PA, June 2001 84. Medicine Grand Rounds, University of South Dakota. New Developments in the

Treatment of Congestive Heart Failure, Sioux Falls, SD, September 2001 85. Cardiovascular Grand Rounds, Brigham & Women’s Hospital, Harvard Medical School.

Molecular Mechanisms for Heart Failure: New Therapeutic Opportunities, Boston, MA, January 2002

Richard A. Walsh, M.D. Curriculum Vitae(Continued) Page 33 86. Invited Speaker, Albert Einstein College of Medicine, Department of Pathology, New York, New York, April 2002 87. NIH Professor in Cardiovascular Research, Mayo Clinic, Rochester, Minnesota,

September 2002 88. Visiting Professor, University of North Carolina, Division of Cardiology Heart Center

Grand Rounds, Chapel Hill, North Carolina, September 2003 89. Robert J. Glaser Clinical Star Program Visiting Professor, Washington University, St. Louis, Missouri, October 2003 90. Invited Speaker, Dean’s Conference, School of Medicine, University of Puerto Rico, San

Juan, Puerto Rico, October 2003 91. Visiting Professor, University of Ottawa Heart Institute Grand Rounds, Ottawa, Ontario,

Canada, May 2010

Richard A. Walsh, M.D. BIBLIOGRAPHY MANUSCRIPTS PUBLISHED: 1. Walsh RA, O'Rourke RA. The present therapeutic role of digitalis. DRUG THERAPY

8:61-76, 1978. 2. Walsh RA, O'Rourke RA. Clues to the evaluation of chest pain from the patient's history.

PRACTICAL CARDIOLOGY 4:41-48, 1978. 3. Walsh RA, O'Rourke RA. Hemodynamic effects of cardiac pacing. In: Varriale P, and

Naclerio E, eds., Cardiac Pacing, A Concise Guide to Clinical Practice. Philadelphia: Lea & Febiger, pp. 123-129, 1979.

4. Walsh RA, Horwitz LD. Adverse hemodynamic effects of disopyramide compared with

quinidine in conscious dogs. CIRCULATION 60:1053-1058, 1979. 5. Walsh RA, O'Rourke RA. The diagnosis and management of acute left sided valvular

regurgitation. Current Problems in Cardiology, Vol. IV, December, pp. 1-34, 1979. 6. Walsh RA, O'Rourke RA. Percutaneous transluminal coronary angioplasty: Cautious

optimism tempered by limited applicability. ANN INTERN MED 91:779-781, 1979. 7. Starling MR, Crawford MH, Walsh RA, O'Rourke RA. Value of the tricuspid echogram

for estimating right ventricular diastolic pressure. AM J CARDIOL 45:966-972, 1980. 8. Walsh RA, Badke FR, O'Rourke RA. Differential effects of systemic and intracoronary

administration of calcium channel blockers on global and regional left ventricular function in conscious dogs. AM HEART J 102:341-350, 1981.

9. Walsh RA, O'Rourke RA. The physical examination in acute uncomplicated and

complicated myocardial infarction. In: Karliner, Joel S, ed. Coronary Care. New York: Churchill-Livingston, pp. 117-185, 1981.

10. Badke FR, Walsh RA, Crawford MH, Ludden T, O'Rourke RA. Hemodynamic effects of

N-acetyl procainamide compared to procainamide in conscious dogs. CIRCULATION 64:1142-1150, 1981.

Richard A. Walsh, M.D. Bibliography(Continued) Page 2 11. Walsh RA, O'Rourke RA. History and differential diagnosis of acute myocardial

infarction. In: Karliner JS, ed., Coronary Care. New York: Churchill-Livingston, pp. 169-175, 1981.

12. Sodums MT, Walsh RA, O'Rourke RA. Digitalis in heart failure -- Farewell to the

foxglove? J A M A 246:158-160, 1981. 13. Horwitz LD, Groves BM, Walsh RA, Sorensen SM, Latson TW. Functional significance

of coronary collateral vessels in patients with coronary artery disease. AM HEART J 104:221-226, 1982.

14. Walsh RA, Crawford MH, O'Rourke RA. Relative sensitivity of echocardiography and

systolic time intervals for assessing acute positive inotropic interventions in normal human subjects. AM HEART J 104:1061-1069, 1982.

15. Porter CB, Walsh RA, Badke FR, O'Rourke RA. Differential effects of diltiazem and

nitroprusside on left ventricular function in experimental chronic volume overload. CIRCULATION 68:685-693, 1983.

16. Easton D, Walsh RA, O'Rourke RA. Faintness and syncope. In: 1st Edition Stein JA, ed.

Internal Medicine: A Systematic Approach. Boston: Little, Brown and Company, pp. 824-828, 1983.

17. Williford DJ, Zavadil AP, Walsh RA, Weise V, Kopin IJ, Gillis RA. Influence of

vagotomy on changes in feline plasma catecholamine levels induced by occlusion of either the left or right coronary vessel. CARDIOVASC RES 17:568-576. 1983.

18. Walsh RA, O'Rourke RA. Palpitations. In: 1st Edition Stein JA, ed., Internal Medicine:

A Systematic Approach. Boston: Little, Brown and Company, pp. 474-476, 1983. 19. Walsh RA, O'Rourke RA. Chest Pain. In: 1st Edition Stein JA, ed., Internal Medicine: A

Systematic Approach. Boston: Little, Brown and Company, pp. 471-474, 1983. 20. O'Rourke RA, Walsh RA. Acute aortic regurgitation. In: Roberts, William ed. Aortic

Stenosis and regurgitation. York Medical Publishers, Chapter 56. Boston: Little, Brown and Company, pp. 253-274, 1983.

21. Starling MR, Dell'Italia LJ, Walsh RA, Little WC, Benedetto AR. Equilibrium

radionuclide angiographic estimates of absolute left ventricular volumes: Importance of attenuation correction. J NUCL MED 25:14-20, 1984.

22. Walsh RA, Porter C, Starling MR, O'Rourke RA. Beneficial hemodynamic effects of

intravenous and oral diltiazem in severe congestive heart failure. J AM COLL CARDIOL 3:1044-1050, 1984.

Richard A. Walsh, M.D. Bibliography(Continued) Page 3 23. Cleary F, Walsh RA. Myocardial dysfunction. In: Contemporary Issues Nephrology ,

Vol. 13, Cardiovascular complications of renal failure. New York, Churchill Livingston, pp. 155-188, 1984.

24. Starling MR, Dell'Italia LJ, Walsh RA, Little WC, Benedetto AR, Nusynowitz ML.

Accurate estimates of absolute left ventricular volumes by equilibrium radionuclide angiography using a simple geometric attenuation correction. J AM COLL CARDIOL 3:789-798, 1984.

25. Myers DG, McManus B, McCall D, Walsh RA, Quaife MA. Anomalous origin of the

right coronary artery from the septal perforator. CATH AND CARDIOVASC DIAG 10:479-484, 1984.

26. Walsh RA. Exertional angina after coronary bypass surgery. CARDIOVASC ROUNDS,

7:1-8, 1984. 27. Dell'Italia LJ, Walsh RA. Hemodynamic profile of constrictive pericarditis produced by a

massive pleural effusion. CATH AND CARDIOVASC DIAG 10:471-477, 1984. 28. Walsh RA, O'Rourke RA. Direct and indirect effects of calcium entry blocking agents on

isovolumic left ventricular relaxation in conscious dogs. J CLIN INVEST 75:1426-1435, 1985.

29. McCall D, Walsh RA, Frohlich E, O'Rourke RA. Calcium entry blocking drugs:

Mechanisms of action experimental studies and clinical uses. CURRENT PROBLEMS IN CARDIOLOGY 10:1-80, 1985.

30. Russel IJ, Walsh RA. Selection of vasodilator therapy for severe Raynaud's phenomenon

by sequential arterial infusion. ANN RHEUM DIS 44:151-154, 1985. 31. Dell'Italia LJ, Starling MR, Walsh RA, Badke FR, Lasher JL, Blumhardt R. Validation of

attenuation-corrected equilibrium radionuclide angiographic right ventricular volume determinations: Comparison with biplane cineventriculography. CIRCULATION 72:317-326, 1985.

32. Starling MR, Dehmer GJ, Lancaster JL, Lasher JC, Walsh RA, Weiland FJ, Uhl GS,

Blumhardt R. Segmental coronary artery disease: Detection by rotating slanthole collimator tomography and planar thallium-201 myocardial scintigraphy. RADIOLOGY 157:231-237, 1985.

33. Kern M, Walsh RA, Barr WK, Porter CB, O'Rourke RA. Improved myocardial oxygen

utilization by diltiazem in patients. AM HEART J 110:986-990, 1985.

Richard A. Walsh, M.D. Bibliography(Continued) Page 4 34. Starling MR, Walsh RA. Accuracy of biplane axial oblique and oblique cineangiographic

left ventricular cast volume determinations using a modification of Simpson's rule algorithm. AM HEART J 110:1219-1225, 1985.

35. Walsh RA. Underestimation of prosthetic mitral valve areas: Role of transseptal

catheterization (letter to editor). J AM COLL CARDIOL 7:1182, 1986. 36. Applegate RJ, Walsh RA. Management of a patient with ischemic heart disease and left

ventricular dysfunction. CARDIOVASCULAR MEDICINE FOR THE PRACTICING PHYSICIAN 1(2): 1986.

37. O'Rourke RA, Walsh RA. Recognition and treatment of acute aortic regurgitation. J

INTENSIVE CARE, 1:33-46, 1986. 38. Walsh RA, Cleary FX, O'Rourke RA. The effects of calcium entry blockade on left

ventricular dynamics in exercising dogs. AM J PHYSIOL 20:H656-H663, 1986. 39. Walsh RA. Congestive heart failure: Pathophysiology, diagnosis, management.

Monograph, Edition No. 85, Home Study Self-Assessment Program. Kansas City, MO: American Academy of Family Physicians, 1986.

40. O'Rourke RA, Walsh RA. Experience with calcium antagonist drugs in congestive heart

failure. AM J CARDIOL 59:64B-69B, 1987. 41. Walsh RA. Cardiovascular effects of the aging process. AM J MED 82(Suppl 1B):34-40,

1987. 42. Walsh RA, O'Rourke RA, Easton JD. Faintness and syncope. In: 2nd Edition Stein JA,

ed., Internal Medicine. Boston: Little, Brown and Company, pp. 2141-2145, 1987. 43. Walsh RA, O'Rourke RA. Chest Pain. In: 2nd Edition Stein JA, ed., Internal Medicine.

Boston: Little, Brown and Company, pp. 370-374, 1987. 44. Starling MR, Walsh RA, Dell'Italia LJ, Mancini GBJ, Lasher JC, Lancaster JL. The

relationship of various measures of end-systole to left ventricular maximum time-varying elastance in man. CIRCULATION 76:32-43, 1987.

45. Nusynowitz ML, Benedetto AR, Walsh RA, Starling MR. First pass anger camera

radiocardiography: biventricular ejection fraction, flow, and volume measurements. J NUCL MED 28:950-959, 1987.

Richard A. Walsh, M.D. Bibliography(Continued) Page 5 46. Latham RD, Rubal BJ, Westerhof N, Sipkema P, Walsh RA. Nonhuman primate model

for regional wave travel and reflections along aortas. AM J PHYSIOL 253:H299-H306, 1987.

47. Walsh RA. The effects of calcium-entry blockade on left ventricular systolic and diastolic

function. CIRCULATION 75(Suppl V)V-43-V-55, 1987. 48. Miller W, Walsh RA, McCall D. Eosinophilic heart disease presenting with features

suggesting hypertrophic obstructive cardiomyopathy. CATH AND CARDIOVASC DIAG 13:185-188, 1987.

49. Crawford MH, Walsh RA, Cragg D, Freeman GL, Miller J. Echocardiographic left

ventricular mass and function in the Hypertensive Baboon. HYPERTENSION 10:339-345, 1987.

50. Starling MR, Walsh RA, Dehmer GJ, Lasher T, Blumhardt R. Value of tomographic

Thallium-201 imaging in patients with chest pain following coronary artery bypass grafting. CLIN NUCL MED 12:134-139, 1987.

51. Applegate RJ, Walsh RA, O'Rourke RA. Frequency dependent myocardial depression

induced by verapamil in conscious dogs. AM J PHYSIOL 253:H487-H492, 1987. 52. Starling MR, Walsh RA, Lasher JC, Lancaster JL, Blumhardt R. Quantification of left

ventricular regional dyssynergy by radionuclide angiography. J NUCL MED 28:1725-1735, 1987.

53. Walsh RA, O'Rourke RA. Palpitations. In: 2nd Edition Stein JA, ed., Internal Medicine.

Boston: Little, Brown and Company, pp. 374-375, 1987. 54. Applegate RJ, Walsh RA, O'Rourke RA. Effects of nifedipine on diastolic function

during brief periods of flow limiting ischemia in the conscious dog. CIRCULATION 76(6):1409-1421, 1987.

55. Starling MR, Montgomery DG, Mancini GB, Walsh RA. Load independence of the rate

of isovolumic relaxation in man. CIRCULATION 76:1274-1281, 1987. 56. Zinn P, Applegate RJ, Walsh RA. Acute total aortic occlusion during cardiac

catheterization associated with polycythemia vera. CATH AND CARDIOVASC DIAG 14:108-110, 1988.

57. Hachamovitch R, Strom J, Sonnenblick E, Frishman W. Left ventricular hypertrophy in

hypertension and the effects of antihypertensive drug therapy. Ed. Walsh RA, Current Problems in Cardiology, Chicago, Year Book Publishers. Vol. 13:371-421, 1988.

Richard A. Walsh, M.D. Bibliography(Continued) Page 6 58. Henkel R, VandeBerg J, Walsh RA. A microassay for ATPase. ANALYTICAL

BIOCHEMISTRY 169:312-318, 1988. 59. Dell'Italia LJ, Walsh RA. Right ventricular diastolic pressure-volume relations and

regional dimensions during acute alterations in loading conditions. CIRCULATION 77:1276-1282, 1988.

60. Starling MR, Gross MD, Walsh RA, Dell'Italia LJ, Montgomery DG, Squicciarini SA,

Blumhardt R. Assessment of the radionuclide angiographic left ventricular maximum time-varying elastance calculation in man. J NUCL MED 29:1368-1381, 1988.

61. Starling MR, Gross MD, Walsh RA, Mancini GBJ, Blumhardt R. Radionuclide

determination of the relationship between left ventricular contractile function and ejection fraction. AM HEART J 116:790-798, 1988.

62. Bussey HI, Hawkins DW, Gaspard JJ, Walsh RA. A comparative trial of digoxin and

digitoxin in the treatment of congestive heart failure. CLINICAL PHARMACOLOGY 8:235-240, 1988.

63. Latham RD, Rubal BJ, Westerhof N, Sipkema P, Virmani R, Rabinowitz M, Walsh RA.

Ventricular/vascular coupling and regional arterial dynamics in the chronically hypertensive baboon: correlation with cardiovascular structural adaptation. CIRC RES 63:798-811, 1988.

64. Dell'Italia LJ, Walsh RA. Acute determinants of the hangout interval in the pulmonary

circulation. AM HEART J 116:1289-1297, 1988. 65. Dell'Italia LJ, Walsh RA. Application of a time-varying elastance model to right

ventricular performance in man. CARDIOVASC RES 22:864-874, 1988. 66. Dell'Italia LJ, Walsh RA. Effect of intravenous metoprolol on left ventricular

performance in Q-wave acute myocardial infarction. AM J CARDIOL 63:166-171, 1989. 67. Walsh RA. Congestive heart failure and cardiomyopathy. In: Textbook of Nephrology,

Second Edition, eds. Massry SG and Glassock RJ. Williams and Wilkins, Vol. 2, Chapter 67, 1177-1182, 1989.

68. Henkel RD, VandeBerg JL, Shade RE, Leger JJ, Walsh RA. Cardiac beta myosin heavy

chain diversity in normal and chronically hypertensive baboons. J CLIN INVEST 83:1487-1493, 1989.

69. Starling MR, Montgomery DG, Walsh RA. Load dependence of the single beat maximal

pressure (stress)-volume ratios in man. J AM COLL CARDIOL 14:345-353, 1989.

Richard A. Walsh, M.D. Bibliography(Continued) Page 7 70. Watford WH, Walsh RA, O'Rourke RA. Diltiazem attenuates the inotropic and peripheral

vascular effects of cardiac glycosides. AM HEART J 118:738-747, 1989. 71. Konz KH, Haap M, Hill KE, Burk RF, Walsh RA. Diastolic dysfunction of perfused rat

hearts induced by hydrogen peroxide. Protective effect of selenium. J MOL CELL CARDIOL 21:789-795, 1989.

72. Hixson JE, Henkel RD, Britten ML, Vernier DT, deLemos RA, VandeBerg JL, Walsh

RA. -Myosin heavy chain cDNA structure and gene expression in adult, fetal, and premature baboon myocardium. J MOL CELL CARDIOL 21:1073-1086, 1989.

73. Walsh RA. The effects of calcium entry blockade on normal and ischemic ventricular

diastolic function. CIRCULATION 80(Suppl IV):IV-52-IV-58, 1989. 74. Applegate RJ, Walsh RA, O'Rourke RA. Comparative effects of pacing-induced and

flow-limited ischemia: The effect of severity versus type of myocardial ischemia on diastolic function. CIRCULATION 81:1380-1392, 1990.

75. Walling A, O'Rourke RA, Walsh RA. History and physical examination for acute

myocardial infarction. In: 1st Edition Alpert JS, ed. Modern Coronary Care. Boston: Little, Brown and Company, pp. 71-93, 1990.

76. Walsh RA. Evaluation of ventricular diastolic function using invasive techniques. AM J

CARDIAC IMAGING 4(2):138-146, 1990. 77. Walsh RA. Sympathetic control of diastolic function in congestive heart failure.

CIRCULATION 82(Suppl I):I-52-I-58, 1990. 78. Miller DD, Salinas F, Walsh RA. Simultaneous cardiac mechanics and phosphorus-31

NMR spectroscopy during global myocardial ischemia and reperfusion in the intact dog. MAG RES MED 17:41-52, 1991.

79. Miller DD, Walsh RA. In vivo phosphorus-31 NMR spectroscopy of abnormal

myocardial high-energy phosphate metabolism during cardiac stress in hypertensive-hypertrophied non-human primates. INT J CARD IMAG 6:57-70, 1991.

80. Konz KH, Walsh RA, Hill KE, Xia Y, Lane JM, Haap M, Burk RF. Cardiac injury

caused by selenium and vitamin E deficiency in the minipig: biochemical and hemodynamic studies. J TRACE ELEM EXP MED 4:61-67, 1991.

81. Walsh RA, Henkel R, Robbins J. Cardiac myosin heavy- and light-chain gene expression

in hypertrophy and heart disease. HEART FAILURE 6:238-243, 1990/91.

Richard A. Walsh, M.D. Bibliography(Continued) Page 8 82. Miller DD, O'Rourke RA, Walsh RA. Phosphorus-31 nuclear magnetic resonance

spectroscopy of the high-energy phosphate metabolic recovery from pacing-induced and flow-limited ischemia in the intact dog in vivo. CORONARY ARTERY DISEASE 2:361-371, 1991.

83. Miller DD, Walsh RA. Phosphorous-31 nuclear magnetic resonance-derived high- energy

phosphate metabolic effects of calcium entry blockade during recovery from global ischemia in the intact circulation. CORONARY ARTERY DISEASE 2:913-922, 1991.

84. Konz KH, Haap M, Walsh RA, Burk RF, Seipel L. Selenium as a protector of diastolic

function during oxidant stress. J TRACE ELEM ELECTROLYTES HEALTH DIS 5:87-93, 1991.

85. Konz KH, Haap M, Walsh RA, Burk RF, Seipel L. Diastolic dysfunction as a precursor

of myocardial damage by reoxygenation. EUR HEART J 12(Suppl D):182-186, 1991. 86. Hoit BD, Walsh RA. Regional atrial distensibility. AM J PHYSIOL 262 (Heart Circ

Physiol 31):H1356-H1360, 1992. 87. Hoit BD, Shao Y, Gabel M, Walsh RA. Influence of loading conditions and contractile

state on pulmonary venous flow: Validation of Doppler velocimetry. CIRCULATION 86:651-659, 1992.

88. Walsh RA. Basic principles of cardiovascular physiology. In: Essentials of Basic

Science: Physiology, Sperelakis and Banks, ed. Boston: Little, Brown and Company, Chapter 16, pp. 245-250, 1993.

89. Hoit BD, Walsh RA. Determinants of left ventricular performance and cardiac output. In:

Essentials of Basic Science: Physiology, Sperelakis and Banks, ed. Boston: Little, Brown and Company, Chapter 19, pp. 289-302, 1993.

90. Wexler LF, Walsh RA. The coronary circulation; myocardial oxygen consumption and

energetics. In: Essentials of Basic Science: Physiology, Sperelakis and Banks, ed. Boston: Little, Brown and Company, Chapter 20, pp. 303-318, 1993.

91. Iwamoto HS, Walsh RA. Hemodynamics and regional circulation. In: Essentials of

Basic Science: Physiology, Sperelakis and Banks, ed. Boston: Little, Brown and Company, Chapter 21, pp. 319-340, 1993.

92. Blaustein AS, Walsh RA. Regulation of the cardiovascular system. In: Essentials of

Basic Science: Physiology, Sperelakis and Banks, ed. Boston: Little, Brown and Company, Chapter 23, pp. 351-372, 1993.

Richard A. Walsh, M.D. Bibliography(Continued) Page 9 93. Hoit BD, Shao Y, Tsai LM, Patel R, Gabel M, Walsh RA. Altered left atrial compliance

after atrial appendectomy: Influence on left atrial and ventricular filling. CIRC RES 72:167-175, 1993.

94. Hoit BD, Shao Y, McMannis K, Gabel M, Walsh RA. Determination of left atrial volume

using sonomicrometry: A cast validation study. AM J PHYSIOL 264 (Heart Circ Physiol 33):H1011-H1016, 1993.

95. Henkel RD, Kammerer CM, Escobedo LV, VandeBerg JL, Walsh RA. Correlated

expression of atrial myosin heavy chain and regulatory light chain isoforms. CARDIOVASC RES 27:416-422, 1993.

96. Hoit BD, Walsh RA, Shao Y, Gabel M, Millard R. Comparative assessment of regional

left atrial perfusion by laser Doppler and radionuclide microsphere techniques: Concordance of regional atrial microcirculatory flux and atrial microsphere blood flow. CARDIOVASC RES 27:508-514, 1993.

97. Bhat G, Burwig S, Walsh RA. Morbidity of endomyocardial biopsy in cardiac transplant

recipients. AM HEART J 125:1180-1181, 1993. 98. Hoit BD, Walsh RA. Diastolic function in hypertensive heart disease. In: Heart Failure

and Left Ventricular Diastolic Function, Gaasch and LeWinter, ed. Lea and Febiger, Chapter 21, pp. 354-372, 1993.

99. Hoit BD, Shao Y, Gabel M, Walsh RA. Influence of the pericardium on left atrial

compliance and pulmonary venous flow. AM J PHYSIOL 264 (Heart Circ Physiol 33):H1781-H1787, 1993.

100. Garrido JM, Gerson MC, Hoit BD, Walsh RA. Load independence of early diastolic

filling parameters. J NUCL MED 34(9):1520-1528, 1993. 101. Corey WA, Markel ML, Hoit BD, Walsh RA. Regression of a dilated cardiomyopathy

following radiofrequency ablation of an incessant supraventricular tachycardia. AM HEART J 126:1469-1473, 1993.

102. Gerson MC, Millard RW, Roszell NJ, McGoron AJ, Gabel M, Washburn LC,

Biniakiewicz D, Blankenship D, Mallin WH, Elder RC, Deutsch E, Walsh RA. Kinetic properties of 99mTc-Q12 in canine myocardium. CIRCULATION 89:1291-1300, 1994.

103. Gerson MC, Lukes J, Deutsch E, Biniakiewicz D, Washburn LC, Elgazzar AH, Elder RC,

Walsh RA. Comparison of technetium-99m-Q3 and thallium-201 for detection of coronary artery disease in humans. J NUCL MED 35:580-586, 1994.

Richard A. Walsh, M.D. Bibliography(Continued) Page 10 104. Gibler WB, Sayre MR, Levy RC, Runyon JP, Kacich R, Hamilton C, Walsh RA. Serial

12-lead electrocardiographic monitoring in patients presenting to the emergency department with chest pain. J ELECTROCARD 26:238-243, 1994.

105. Hoit BD, Shao Y, Gabel Y, Walsh RA. In vivo assessment of left atrial contractile

performance in normal and pathological conditions using a time-varying elastance model. CIRCULATION 89:1829-1838, 1994.

106. Dorn GW, Robbins J, Ball N, Walsh RA. Myosin heavy chain regulation and myocyte

contractile depression after left ventricular hypertrophy in aortic banded mice. AM J PHYSIOLOGY 267 (Heart Circ Physiol 36):H400-H405, 1994.

107. Walsh RA. Special Feature: Advances in our understanding of congestive heart failure.

Focus and Opinion: Internal Medicine, Vol. 1 (5):3-11, Sept/Oct 1994. 108. Gerson MC, Millard RW, McGoron A, Gabel M, Washburn LC, Biniakiewicz D, Elder

RC, Deutsch E, Walsh RA. Myocardial uptake and kinetic properties of Technetium-99m-Q3 in dogs. J NUCL MED 35:1698-1706, 1994.

109. Hoit BD, Burwig S, Eppert D, Bhat G, Walsh RA. Effects of a novel inotropic agent

(OPC-18790) on systolic and diastolic function in patients with severe heart failure. AM HEART J 128:1156-1163, 1994.

110. Gerson MC, Lukes J, Deutsch E, Biniakiewicz D, Rohe RC, Washburn LC, Fortman C,

Walsh RA. Comparison of technetium 99m Q12 and thallium 201 for detection of angiographically documented coronary artery disease in humans. J NUCL CARDIOL 1:499-508, 1994.

111. Hoekstra JW, Gibler WB, Levy RC, Sayre M, Naber W, Chandra A, Kacich R, Magorien

R, Walsh RA. Emergency-department diagnosis of acute myocardial infarction and ischemia: A cost analysis of two diagnostic protocols. ACAD EMERG MED 1:103-110, 1994.

112. O'Rourke RA, Walsh RA. Palpitations. In: Internal Medicine, Fourth Edition, Stein JA,

ed. Mosby Year Book Company, pp. 92-93, 1994. 113. O'Rourke RA, Walsh RA. Syncope and faintness. In: Internal Medicine. Fourth Edition,

Stein JA, ed. Mosby Year Book Company, pp. 1020-1025, 1994. 114. Gibler WB, Runyon JP, Levy RC, Sayre MR, Kacich R, Hattemer C, Hamilton C, Gerlach

JW, Walsh RA. A rapid diagnostic and treatment center for patients with chest pain in the emergency department. ANN EMERG MED 25(1):1-8, 1995.

Richard A. Walsh, M.D. Bibliography(Continued) Page 11 115. Hoit BD, Shao Y, Gabel M, Walsh RA. Disparate effects of early pressure overload

hypertrophy on velocity-dependent and force-dependent indices of ventricular performance in the conscious baboon. CIRCULATION 91:1213-1220, 1995.

116. Hoit BD, Shao Y, Kinoshita A, Gabel M, Husain A, Walsh RA. Effects of angiotensin II

generated by an angiotensin converting enzyme-independent pathway on left ventricular performance in the conscious baboon. J CLIN INVEST 95:1519-1527, 1995.

117. Hoit BD, Shao Y, Gabel M, Walsh RA. Left atrial mechanical and biochemical

adaptation to pacing induced heart failure. CARDIOVASC RES 29:469-474, 1995. 118. Wagoner LE, Walsh RA. Inotropic therapy for systolic heart failure. COMPREHEN

THER - 21(7):367-377, 1995. 119. Gerson MC, Lukes J, Deutsch E, Biniakiewicz D, Washburn LC, Walsh RA. Comparison

of imaging properties of technetium 99m Q12 and technetium 99m Q3 in humans. J NUCL CARDIOL 2:224-230, 1995.

120. Lenihan DJ, Gerson MC, Hoit BD, Walsh RA. Mechanisms, diagnosis, and treatment of

diastolic heart failure. AM HEART J 130:153-66, 1995. 121. Gerson MC, Lukes J, Deutsch E, Biniakiewicz D, Washburn LC, Walsh RA. Comparison

of imaging properties of Tc-99m Q12 and Tc-99m Q3 in man. In: Technetium and Rhenium in Chemistry and Nuclear Medicine. Nicolini M, Bandoli G, Mazzi U (Editors). SGE Editoriali, Padova, Italy, 1995.

122. Hoit BD, Khoury SF, Kranias EG, Ball N, Walsh RA. In vivo echocardiographic

detection of enhanced left ventricular function in gene targeted mice with phospholamban deficiency. CIRC RES 77:632-637, 1995.

123. Murray DR, O'Rourke RA, Walling AD, Walsh RA. History and physical examination in

myocardial ischemia and acute myocardial infarction. In: Modern Coronary Care, Second Edition, Francis G and Alpert J, eds. Little, Brown and Company, pp. 73-94, 1995.

124. Kiss E, Ball NA, Kranias EG, Walsh RA. Differential changes in cardiac phospholamban

and sarcoplasmic reticular Ca2+-ATPase protein levels: effects on Ca2+ transport and mechanics in compensated pressure overload hypertrophy and congestive heart failure. CIRC RES 77:759-764, 1995.

125. Gerson MC, Shao Y, Gabel M, Huth C, Hoit BD, Walsh RA. Load independence of

radionuclide diastolic filling measurements in acute coronary occlusion. J NUCL CARDIOL 2:491-498, 1995.

Richard A. Walsh, M.D. Bibliography(Continued) Page 12 126. Kadambi VJ, Ponniah S, Koss KL, Harrer JM, Dorn II GW, Walsh RA, Kranias EG.

Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice. J CLIN INVEST 97:533-539, 1996.

127. Baker D, Arai M, Matsui H, Sukovich D, Shabbeer J, Dave V, Walsh RA, Periasamy M.

Regulation of sarcoplasmic reticulum gene expression during cardiac hypertrophy and heart failure. In: Heart Hypertrophy and Failure, Dhalla, Pierce, Panagia and Beamish, ed. Kluwer Academic Publishers, Boston, pp. 139-154, 1995.

128. Genovese B, Walsh RA. Diagnostic and therapeutic cardiac catheterization and coronary

angiography. In: Classic Teachings in Clinical Cardiology. A tribute to W. Proctor Harvey, M.A. Chizner, ed., Laennec Publishing, Cedar Grove, NJ, Chap. 19, pp. 419-453, 1996.

129. Walsh RA. Basic principles of cardiovascular physiology. In: Essentials of Basic

Science: Physiology, Second Edition, Sperelakis and Banks, ed. Boston: Little, Brown and Company, Chapter 20, pp. 243-246, 1996.

130. Hoit BD, Walsh RA. Determinants of left ventricular performance and cardiac output. In:

Essentials of Basic Science: Physiology, Second Edition, Sperelakis and Banks, ed. Boston: Little, Brown and Company, Chapter 23, pp. 269-278, 1996.

131. Wexler LF, Walsh RA. Coronary circulation, myocardial oxygen consumption, and

energetics. In: Essentials of Basic Science: Physiology, Second Edition, Sperelakis and Banks, ed. Boston: Little, Brown and Company, Chapter 24, pp. 279-288, 1996.

132. Iwamoto HS, Walsh RA. Hemodynamics and regional circulation. In: Essentials of

Basic Science: Physiology, Second Edition, Sperelakis and Banks, ed. Boston: Little, Brown and Company, Chapter 25, pp. 289-301, 1996.

133. Blaustein AS, Walsh RA. Regulation of the cardiovascular system. In: Essentials of

Basic Science: Physiology, Second Edition, Sperelakis and Banks, ed. Boston: Little, Brown and Company, Chapter 27, pp. 309-321, 1996.

134. Gunteski-Hamblin AM, Song G, Walsh RA, Frenzke M, Boivin GP, Dorn II GW, Kaetzel

MA, Horseman ND, Dedman JR. Annexin VI overexpression targeted to heart alters cardiomyocyte function in transgenic mice. AM J PHYSIOL 270(39):H1091-1100, 1996.

135. Wagoner LE, Walsh RA. The cellular pathophysiology of progression to heart failure.

CURR OPINION CARDIOL 11:237-244, 1996. 136. Collins JF, Pawloski-Dahm CM, Davis MG, Ball NA, Dorn II GW, Walsh RA. The role

of the cytoskeleton in left ventricular pressure overload hypertrophy and failure. J MOL CELL CARDIOL 28:1435-1443, 1996.

Richard A. Walsh, M.D. Bibliography(Continued) Page 13 137. Khoury SF, Hoit BD, Dave V, Pawloski-Dahm CM, Shao Y, Gabel M, Periasamy M,

Walsh RA. Effects of thyroid hormone on left ventricular performance and regulation of contractile and Ca2+ cycling proteins in the baboon: Implications for the force frequency and relaxation frequency relationships. CIRC RES 79:727-735, 1996.

138. Lenihan DJ, Gerson MC, Dorn II GW, Hoit BD, Walsh RA. Effects of changes in the

atrioventricular gradient and contractility on left ventricular filling in human diastolic cardiac dysfunction. AM HEART J 132:1179-1188, 1996.

139. Shao Y, Khan ZU, Gabel M, Hoit BD, Walsh RA Gerson MC. Effect of inotropic and

load conditions on radionuclide diastolic indices with pacing-induced cardiomyopathic heart failure. J NONINVASIVE CARDIOL I(II):18-24, 1997.

140. Walsh RA. Editorial. Microtubules and pressure overload hypertrophy. CIRC RES

80:295-296, 1997. 141. Cohn JN, Bristow MR, Chien KR, Colucci WS, Frazier OH, Leinwand LA, Lorell BH,

Moss AJ, Sonnenblick EH, Walsh RA, Mockrin SC, Reinlib L. Report of the National Heart, Lung, and Blood Institute Special Emphasis Panel on Heart Failure Research. CIRCULATION 95:766-770, 1997.

142. Hoit BD, Khan ZU, Pawloski-Dahm CM, Walsh RA. Special Communication. In vivo

determination of the left ventricular wall stress-shortening relationship in normal mice. AM J PHYSIOL 272:H1047-H1052, 1997.

143. Liao Y, Yi T, Hoit BD, Walsh RA, Karnik SS, Husain A. Selective reporter expression in

mast cells using a chymase promoter. J BIOL CHEM 272:2969-2976, 1997. 144. Hoit BD, Pawloski-Dahm CM, Shao Y, Gabel M, Walsh RA. The effects of a thyroid

hormone analog on left ventricular performance and contractile and calcium cycling proteins in the baboon. PROC ASSOC AM PHYS 109(2):136-145, 1997.

145. Hoit BD, Walsh RA. In vivo echocardiographic assessment of left ventricular function in

transgenic and gene-targeted mice. TRENDS CARDIOVASC MED 7:129-134 1997. 146. Hoit BD, Khoury SF, Shao Y, Gabel M, Liggett SB, Walsh RA. Effects of thyroid

hormone on cardiac -adrenergic responsiveness in conscious baboons. CIRCULATION 95(2):592-598, 1997.

147. D'Angelo DD, Sakata Y, Lorenz JN, Boivin GP, Walsh RA, Liggett SB, Dorn GW II.

Transgenic Gq overexpression induces cardiac contractile failure in mice. PROC NAT ACAD SCI 94(15):8121-8126, 1997.

Richard A. Walsh, M.D. Bibliography(Continued) Page 14 148. Hoit BD, Shao Y, Gabel M, Pawloski-Dahm C, Walsh RA. Left atrial systolic and

diastolic function after cessation of pacing in tachycardia-induced heart failure. AM J PHYSIOL 273(2):H921-H927, 1997.

149. Wakasaki H, Koya D, Schoen FJ, Hoit BD, Jirousek MR, Ways DK, Walsh RA, King GL.

Targeted overexpression of protein kinase C 2 isoform in myocardium causes cardiomyopathy. PROC NAT ACAD SCI 94:9320-9325, 1997.

150. Chu G, Dorn GW II, Luo W, Harrer JM, Kadambi VJ, Walsh RA, Kranias EG.

Monomeric phospholamban overexpression in transgenic mouse hearts. CIRC RES 81:485-492, 1997.

151. Paul K, Ball NA, Dorn GW II, Walsh RA. Left ventricular stretch stimulates angiotensin

II-mediated phosphatidylinositol hydrolysis and protein kinase C isoform translocation in adult guinea pig hearts. CIRC RES 81:643-650, 1997.

152. Hoit BD, Ball N, Walsh RA. Invasive hemodynamics and force-frequency relations in

open- versus closed-chest mice. AM J PHYSIOL 273:H2528-H2533, 1997. 153. Meleca MJ, McGoron AJ, Gerson MC, Millard RW, Gabel M, Biniakiewicz D, Roszell

NJ, Walsh RA. Flow versus uptake comparisons of thallium-201 with technetium-99m perfusion tracers in a canine model of myocardial ischemia. J NUCL MED 38:1847-1856, 1997.

154. Walsh RA, Dorn II GW. Growth and hypertrophy of the heart and blood vessels. In

Hurst's the Heart, Ninth Edition, Alexander, Schlant, and Fuster, ed. New York: McGraw-Hill, Chapter 6, pp. 155-168, 1998.

155. Sakata Y, Hoit BD, Liggett SB, Walsh RA, Dorn GW II. Decompensation of pressure-

overload hypertrophy in Gq-overexpressing mice. CIRCULATION 97:1488-1495, 1998.

156. Pawloski-Dahm C, Song G, Kirkpatrick DL, Palermo J, Gulick J, Dorn GW II, Robbins

J, Walsh RA. Effects of total replacement of atrial myosin light chain-2 with the ventricular isoform in atrial myocytes of transgenic mice. CIRCULATION 97:1508-1513, 1998.

157. Song G, Campos B, Wagoner LE, Dedman JR, Walsh RA. Altered cardiac annexin

mRNA and protein levels in the left ventricle of patients with end-stage heart failure. J MOL CELL CARDIOL 30:443-451, 1998, feature article.

158. Gerson MC, Lukes J, Rosenbaum A, Deutsch EA, Walsh RA, Biniakiewicz D.

Technetium-99m Q4: a prototype cationic perfusion radiotracer with myocardial washout. EUR J NUCL MED 25:353-360, 1998.

Richard A. Walsh, M.D. Bibliography(Continued) Page 15 159. Takeishi Y, Chu G, Kirkpatrick DL, Li Z, Wakasaki H, Kranias EG, King GL, Walsh RA.

In vivo phosphorylation of cardiac troponin I by protein kinase C2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts. J CLIN INVEST 102:72-78, 1998.

160. Walsh RA. The role of angiotensin II in stretch-activated signal transduction of the

normal, hypertrophied, and failing adult heart. In Angiotensin II Receptor Blockade: Physiological and Clinical Implications, ed. by N. S. Dhalla, P. Zahradka, I. M. C. Dixon and R. E. Beamish. Kluwer Academic publishers, Boston, pp. 423-434, 1998.

161. Grupp IL, Lorenz JN, Walsh RA, Boivin GP, Rindt H. Overexpression of 1B-adrenergic

receptor induces left ventricular dysfunction in the absence of hypertrophy. AM J PHYSIOL 275:H1338-H1350, 1998.

162. Loukianov E, Ji Y, Grupp IL, Kirkpatrick DL, Baker DL, Loukianov T, Grupp G, Lytton

J, Walsh RA, Periasamy M. Enhanced myocardial contractility and increased Ca2+ transport function in transgenic hearts expressing the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+ ATPase. CIRC RES 83:889-897, 1998.

163. Baker DL, Hashimoto K, Grupp IL, Yong J, Reed T, Loukianov E, Grupp G, Bhagwat A,

Hoit B, Walsh RA, Marban E, Periasamy M. Targeted overexpression of the sarcoplasmic reticulum Ca2+ ATPase increases cardiac contractility in transgenic mouse hearts. CIRC RES 83:1205-1214, 1998.

164. Liggett SB, Wagoner LE, Craft LL, Hornung RW, Hoit Bd, McIntosh TC, Walsh RA.

The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure. J CLIN INVEST 102:1534-1539, 1998.

165. Sato Y, Ferguson DG, Sako H, Dorn GW II, Kadambi VJ, Yatani A, Hoit BD, Walsh RA,

Kranias EG. Cardiac specific overexpression of mouse cardiac calsequestrin is associated with depressed cardiovascular function and hypertrophy in transgenic mice. J BIOL CHEM 273(43)28470-28477, 1998.

166. Walsh RA. The hierarchical approach to analysis of cardiovascular function in mice: an

overview. In: Cardiovascular Physiology of the Genetically Engineered Mouse, Hoit BD, Walsh RA, Editors, Kluwer Academic Publishers, Boston, Chapter 1, pp. 1-17, 1998.

167. Takeishi Y, Bhagwat A, Ball NA, Kirkpatrick DL, Periasamy M, Walsh RA. Effect of

angiotensin converting enzyme inhibition on protein kinase C and SR proteins in heart failure. AM J PHYSIOL 276(45)H53-H62, 1999.

168. Bowling N, Walsh RA, Song G, Estridge T, Sandusky GE, Fouts RL, Mintze K, Pickard

T, Roden R, Bristow MR, Sabbah HN, Mizrahi JL, Gromo G, King GL, Vlahos CJ.

Richard A. Walsh, M.D. Bibliography(Continued) Page 16

Increased Protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart. CIRCULATION 99(3):384-391, 1999.

169. Khan Z, Millard RW, Gabel M, Walsh RA, Hoit BD. Effect of congestive heart failure on

in vivo canine aortic elastic properties. J AM COLL CARDIOL 33:267-272, 1999. 170. Walsh RA. Calcineurin inhibition as therapy for cardiac hypertrophy and heart failure:

requiescat in pace? CIRC RES 84:741-743, 1999. 171. Lenihan DJ, Rosenbaum AF, Burwinkel P, Tseng CY, Bhat G, Wagoner L, Walsh RA,

Gerson MC. Prediction of human transplantation arteriopathy and coronary events with lung/heart count ratios during intravenous dipyridamole thallium-201 imaging. AM HEART J 137:942-948, 1999.

172. Lenihan DJ, McGoron AJ, Gabel M, Walsh RA, Gerson MC. Reliability of technetium-

99m Q12 and thallium-201 myocardial activity measurements after triphenyl tetrazolium chloride myocardial staining by perfusion. INVEST RADIOL 34:276-281, 1999.

173. Takeishi Y, Jalili T, Ball NA, Walsh RA. Responses of cardiac protein kinase C isoforms

to distinct pathological stimuli are differentially regulated. CIRC RES 85:264-271, 1999. 174. Kadambi VJ, Ball N, Kranias EG, Walsh RA, Hoit BD. Modulation of force frequency

relation by phospholamban in genetically engineered mice. AM J PHYSIOL 276(6):H2245-H2250, 1999.

175. Jalili T, Takeishi Y, Walsh RA. Signal transduction during cardiac hypertrophy: the role

of Gq, PLC I, and PKC. CARDIOVASC RES 44:5-9, 1999. 176. Kristof E, Szigeti G, Papp Z, Bodi A, Ball NA, Walsh RA, Edes I. The effects of

levosimendan on the left ventricular function and protein phosphorylation in post-ischemic guinea pig hearts. BAS RES CARDIOL, 94:223-230, 1999.

177. Hoit BD, Tramuta DA, Kadambi VJ, Dash R, Ball N, Kranias EG, Walsh RA. Influence

of transgenic overexpression of phospholamban on postextrasystolic potentiation. J MOL CELL CARDIOL, 31:2007-2015, 1999.

178. James PF, Grupp IL, Grupp G, Woo AL, Askew GR, Croyle ML, Walsh RA, Lingrel .

Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart. MOL CELL, 3:555-563, 1999.

179. Rosenbaum AF, McGoron AJ, Millard RW, Gabel M, Biniakiewicz D, Walsh RA, Gerson

MC. Uptake of seven myocardial tracers during increased myocardial blood flow augmentation by dobutamine infusion. INVESTIGATIVE RADIOLOGY, 34:91-98, 1999.

Richard A. Walsh, M.D. Bibliography(Continued) Page 17 180. Jalili T, Takeishi G, Song G, Ball NA, Howles G, Walsh RA. PKC translocation without

changes in Gq and PLC- protein abundance in cardiac hypertrophy and failure. AM J PHYSIOL, 277:H2298-H2304, 1999.

181. Takeishi Y, Abe J-i, Lee J-D, Walsh RA, Berk BC. Differential regulation of p90

ribosomal S6 kinase and big mitogen-activated Protein Kinase 1 by ischemia/reperfusion and oxidative stress in perfused guinea pig hearts. CIRC RES, 85:1164-1172, 1999.

182. McGoron AJ, Biniakiewicz D, Millard RW, Kumar A, Kennedy SC, Roszell NJ, Gabel

M, Huth C, Walsh RA, Gerson MC. Myocardial kinetics of 99m-technetium-Q agents: studies in isolated cardiac myocyte, isolated perfused rat heart and canine regional myocardial ischemia models. INVEST RADIOL, 34:704-717, 1999.

183. Sussman MA, Welch S, Gude N, Khoury PR, Daniels SR, Kirkpatrick D, Walsh RA,

Price RL, Lim HW, Molkentin JD. Pathogenesis of dilated cardiomyopathy: molecular, structural, and population analyses in Tropomodulin Overexpressing Transgenics. AM J PATH, 155:2101-2113, 1999.

184. Walsh RA. Journal of Molecular and Cellular Cardiology: Changing of the Guard. J

MOL CELL CARDIOL 31:1171, 1999. 185. Adams KF Jr., the Committee on Guidelines and the Executive Council of the Heart

Failure Society of America. Clinical practice guideline update for the management of patients with heart failure due to left ventricular systolic dysfunction – pharmacologic approaches. J CARDIAC FAILURE, 5(4):357-382, 1999.

186. Walsh RA, Commentary: Chymase: A critical Evaluation of its Role in Angiotensin II

Formation and Cardiovascular Disease. In: Drugs, Enzymes and Receptors of the Renin-antiotensin System: Celebrating a Centry of Discovery, Husain, Graham, ed. Australia: Harwood Academic Publishers, Chapter 17a, pp. 365, 2000.

187. Hoit BD, Kadambi VJ, Tramuta DA, Ball N, Kranias EG, Walsh RA. Influence of

sarcoplasmic reticulum calcium loading on mechanical and relaxation restitution. AM J PHYSIOL, 278:H958-H963, 2000.

188. Takeishi Y, Jalili T, Kirkpatrick DL, Wagoner LE, Abraham WT, Walsh RA. Alterations

in calcium cycling proteins and Gq signaling after left ventricular assist device support in failing human hearts. CARDIOVAS RES, 45:883-888, 2000.

189. Hoit BD, Suresh DP, Craft L, Walsh RA, Liggett SB. 2-Adrenergic receptor

polymorphisms at amino acid 16 differentially influence agonist-stimulated blood pressure and peripheral blood flow in normal individuals. AM HEART J, 139:537-42, 2000.

Richard A. Walsh, M.D. Bibliography(Continued) Page 18 190. Ahmmed GU, Hong Dong P, Song G, Ball NA, Xu Y, Walsh RA, Chiamvimonvat N.

Changes in Ca2+ cycling proteins underlie cardiac action potential prolongation in a pressure overloaded guinea pig model with cardiac hypertrophy and failure. CIRC RES, 86:558-570, 2000.

191. Walsh RA. Protein kinase C activation in cardiac hypertrophy and failure. In: The

Hypertrophied Heart, Takeda, Nagano, Dhalla, ed. Boston: Kluwer Academic Publishers, Chapter 21, pp. 253-263, 2000.

192. Walsh RA. From the Editor: One Year on the Watch. J MOL CELL CARDIOL 32:863-

864, 2000. 193. Takeishi Y, Ping P, Bolli R, Kirkpatrick DL, Hoit BD, Walsh RA. Transgenic

overexpression of constitutively active protein kinase C causes concentric cardiac hypertrophy. CIRC RES 86(12):1218-1223, 2000.

194. Schmidt AG, Kadambi VJ, Ball N, Sato Y, Walsh RA, Kranias EG, Hoit BD. Cardiac-

specific overexpression of calsequestrin results in left ventricular hypertrophy, depressed force-frequency relation and pulsus alternans in vivo. J MOL CELL CARDIOL 32:1735-44, 2000.

195. Ji Y, Lalli MJ, Babu GJ, Xu Y, Kirkpatrick DL, Liu LH, Chiamvimonvat N, Walsh RA,

Shull GE, Periasamy M. Disruption of a single copy of the SERCA2 gene results in altered Ca2+ homeostasis and cardiomyocyte function. J BIOL CHEM 275(48):38073-38080, 2000.

196. Kiatchoosakun S, Kirkpatrick D, Olszens K, Nadeau J, Walsh RA. Naturally occurring

variation in inbred mouse strains: a mouse model of the athlete’s heart. J CARDIAC FAILURE, 6(Suppl.2):12, 2000.

197. Walsh RA. Molecular and Cellular Biology of the Normal, Hypertrophied, and Failing

Heart. In Hurst's the Heart, Tenth Edition, Fuster, Alexander, and O’Rourke, ed. New York: McGraw-Hill, Chapter 5, pp. 115-125, 2001.

Richard A. Walsh, M.D. Bibliography(Continued) Page 19 198. Walsh RA. Editorial. J MOL CELL CARDIOL, 33:1547-1549, 2001. 199. Takeishi Y, Huang Q, Abe J-i, Glassman M, Che W, Lee J-D, Kawakatsu H, Lawrence

EG, Hoit BD, Berk BC, Walsh RA. Src and multiple MAP kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: Comparison with acute mechanical stretch. J MOL CELL CARDIOL, 33:1637-1648, 2001.

200. Takeishi Y, Walsh RA. Cardiac hypertrophy and failure: lessons learned from genetically

engineered mice. ACTA PHYSIOL SCAND, 173:103-111, 2001. 201. Jane Lalli M, Yong J, Prasad V, Hashimoto K, Plank D, Babu GJ, Kirkpatrick D, Walsh

RA, Sussman M, Yatani A, Marbán E, Periasamy M. Sarcoplasmic reticulum Ca(2+) atpase (SERCA) 1a structurally substitutes for SERCA2a in the cardiac sarcoplasmic reticulum and increases cardiac Ca(2+) handling capacity. CIRC RES, 89(2):160-167, 2001.

202. Takeishi Y, Huang Q, Wang T, Glassman M, Yashizumi M, Baines CP, Lee J-D,

Kawakatsu H, Che W, Marmarosh N, Zhang C, Yan C, Ohta S, Walsh RA, Berk BC, Abe J-i. Src family kinase and adenosine differentially regulate multiple MAP kinases in ischemic myocardium: modulation of MAP kinases activation by ischemic preconditioning. J MOL CELL CARDIOL, 33:1989-2005, 2001.

203. Kiatchoosakun S, Lawrence E, Nakada S, Restivo J, Walsh RA, Hoit BD. Effect of

Angiotensin Type I – Receptor Blockade on Left Ventricular Remodeling in Pressure Overload Hypertrophy. J CARDIAC FAILURE, 7(4):342-347, 2001.

204. Kiatchoosakun S, Kirkpatrick D, Walsh RA, Hoit B. The effect of tribromoethanol

anesthesia on the echocardiographic assessment of left ventricular function. COMP MED, 51:27-31, 2001.

205. Takeishi Y, Huang Q, Abe J-i, Che W, Lee J-D, Kawakatsu H, Hoit BD, Berk BC, Walsh

RA. Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy. CARDIOVASC RES, 53:131-137, 2002.

206. Hoit BD, Takeishi Y, Cox MJ, Gabel M, Kirkpatrick D, Walsh RA, Tyagi SC.

Remodeling of the left atrium in pacing-induced atrial cardiomyopathy. MOL CELL BIOCHEM, 238:145-150, 2002.

207. Crist TB, Walsh RA, Alexander RW, Bremner WJ, Schafer AI, Swain JL, Thorner MO,

Weisfeldt ML. The research community now and in the future: APM’s recommendations for NIH priorities. AM J MED, 114:710-713, 2003.

Richard A. Walsh, M.D. Bibliography(Continued) Page 20 208. Schmidt AG, Haghighi K, Frank B, Pater L, Dorn GW, Walsh RA, Kranias EG.

Polymorphic SERCA2a variants do not account for inter-individual differences in phospholamban-SERCA2a interactions in human heart failure. J MOL CELL CARDIOL, 35:867-870, 2003.

209. Walsh RA, Smisek AM. Editorial. J MOL CELL CARDIOL, 35:999-1003, 2003. 210. Crist TB, Schafer AI, Walsh RA. Translating basic discoveries into better health care: the

APM’s recommendations for improving translational research. AM J MED, 116:431-434, 2004.

211. Walsh RA. From the Editor: a new series. J MOL CELL CARDIOL, 36:641, 2004. 212. Walsh RA. Molecular and Cellular Biology of the Normal, Hypertrophied, and Failing

Heart. In Hurst’s the Heart, Eleventh Edition, Fuster, Alexander, and O’Rourke, ed. New York: McGraw-Hill, Chapter 6, pp. 125-133, 2004.

213. Kale P, Walsh RA. Hypertrophic Cardiomyopathy. In: Netter’s Cardiology, Runge and

Ohman, eds. New Jersey: Icon Publishers, Chapter 13, pp. 128-134, 2004. 214. Ortiz J, Walsh RA. Hereditary Cardiomyopathies. In: Netter’s Cardiology, Runge and

Ohman, eds. New Jersey: Icon Publishers, Chapter 15, pp. 151-158, 2004. 215. Ding B, Abe J-i, Wei H, Huang Q, Walsh RA, Molina CA, Zhao A, Sadoshima J, Blaxall

BC, Berk BC, Yan C. Functional Role of Phosphodiesterase 3A (PDE3A) in Cardiomyocyte Apoptosis: Implication in Heart Failure. CIRCULATION , 111:2469-76, 2005.

216. Ito S, Ding B, Bains CP, Maekawa N, Wei H, Yasuchika T, Jalili T, King GL, Walsh RA,

Yan C, Abe J-i. Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and PKC-mediated cardiac Troponin I phosphorylation. J BIOL CHEM, 280:24135-42, 2005.

217. Arimoto T, Takeishi Y, Takahashi H, Shishido T, Niizeki T, Koyama Y, Shiga R, Nozaki

N, Nakajima O, Nishimaru K, Abe J, Endoh M, Walsh RA, Goto K, Kubota I. Cardiac-specific overexpression of diacylglycerol kinase prevents Gq protein-coupled receptor agonist-induced cardiac hypertrophy in transgenic mice. CIRCULATION, 113:60-6, 2006.

218. Roberts R, Gollob M, Walsh RA. Commentary Molecular Cardiology and Genetics in the

21st Century – A Primer. CURR PROBL CARDIOL, 31:637-701, 2006.

Richard A. Walsh, M.D. Bibliography(Continued) Page 21 219. Niizeki T, Takeishi Y, Arimoto T, Takahashi H, Shishido T, Koyama Y,Goto K, Walsh

RA, Kubota I. Cardiac-specific overexpression of diacylglycerol kinase attenuates left ventricular remodeling and improves survival after myocardial infarction. AM J PHYSIOL HEART CIRC PHYSIOL, 292:H1105-H1112, 2007.

220. Harada M, Takeishi Y, Arimoto T, Niizeki T, Kitahara T, Goto K, Walsh RA, Kubota I.

Diacylglycerol kinase attenuates pressure overload-induced cardiac hypertrophy. CIRC J, 71:276-282, 2007.

221. Hoit BD, Walsh RA. Normal Physiology of the Cardiovascular System. In Hurst’s the

Heart, Twelfth Edition, Fuster, O’Rourke, Walsh, Poole-Wilson. New York: McGraw-Hill, Chapter 4, pp. 83-109, 2008.

222. Samarel AM, Walsh RA. Molecular and Cellular Biology of the Normal, Hypertrophied,

and Failing Heart. In Hurst’s the Heart, In Hurst’s the Heart, Twelfth Edition, Fuster, O’Rourke, Walsh, Poole-Wilson. New York: McGraw-Hill, Chapter 6, pp. 123-134, 2008.

223. Loscalzo J, Tomaselli GF, Vaughan DE, Walsh RA. Task Force 7: training in

cardiovascular research. J AM COLL CARDIOL, 51(3):380-3, 2008. 224. Niizeki T, Takeishi Y, Kitahara T, Arimoto T, Ishino M, Bilim O, Suzuki S, Sasaki T,

Nakajima O, Walsh RA, Goto K, Kubota I. Diacylglycerol kinase-ε restores cardiac dysfunction under chronic pressure overload: A new specific regulator of Gq signaling cascade. AM J PHYSIOL HEART CIRC PHYSIOL, 295:H245-H255, 2008.

Richard A. Walsh, M.D. Bibliography(Continued) Page 22 BOOKS: 1. Essentials of Basic Science: Physiology. Little, Brown and Company. Sperelakis and

Banks, ed. Cardiovascular Physiology, Cardiovascular Section Editor, Walsh RA, pp. 241-370, 1992.

2. Essentials of Basic Science: Physiology, Second Edition. Little, Brown and Company.

Sperelakis and Banks, ed. Cardiovascular Physiology, Cardiovascular Section Editor, Walsh RA, pp. 243-323, 1996.

3. Cardiovascular Physiology in the Genetically Engineered Mouse. Kluwer academic

publishers. Editors, Hoit BD, Walsh RA, pp. 286, 1998. 4. Cardiovascular Physiology in the Genetically Engineered Mouse. Kluwer academic

publishers, 2nd Edition. Editors, Hoit BD, Walsh RA, pp. 403, 2002. 5. Netter’s Cardiology: Icon publishers. Runge and Ohman, ed. Mycoardial Diseases and

Cardiomyopathy Section Editor, Walsh RA, pp. 664, 2004. 6. Molecular Mechanisms for Cardiac Hypertrophy and Failure, Taylor Francis publishers,

Editor, Walsh RA, pp. 746, 2005. 7. Hurst’s the Heart, McGraw-Hill publishers, 12th Edition. Senior Editor, Walsh RA, pp.

2477, 2008. 8. Hurst’s the Heart Manual of Cardiology, McGraw-Hill publishers, 12th Edition. Senior

Editor, Walsh RA, pp. 784, 2009. 9. Hurst’s the Heart, McGraw-Hill publishers, 13th Edition. Senior Editor, Walsh RA, 2009,

in press.

Richard A. Walsh, M.D. Bibliography(Continued) Page 23 PRESENTED ABSTRACTS: 1. Walsh RA, Horwitz LD, Bishop VS. The effect of intracoronary isoproterenol infusions

on regional blood flow in the conscious dog. PHYSIOLOGIST 21:125, 1978. 2. Starling MR, Crawford MH, Walsh RA, O'Rourke RA. Value of the tricuspid valve

echogram for estimating right ventricular diastolic pressure. CIRCULATION 58(2):Abstract #902, 1978.

3. Walsh RA, O'Rourke RA, Ludden T, Horwitz LD. Adverse hemodynamic effects of

intravenous disopyramide compared with quinidine in conscious dogs. CLIN RES 26(2):755A, 1978.

4. Groves BM, Walsh RA, Sorensen SG, Horwitz LD. Effect of sublingual nitroglycerin on

regional myocardial blood flow in patients with coronary artery disease at rest and during spontaneous angina pectoris. CLIN RES 27(1):5A, 1979.

5. Walsh RA, O'Rourke RA, Ludden T, Horwitz LD. Adverse hemodynamic effects of

intravenous disopyramide compared with quinidine in conscious dogs. AM J CARDIOL 43:358, 1979.

6. Walsh RA, Badke FR, O'Rourke RA. Differential effects of diltiazem and verapamil on

left ventricular performance on conscious dogs. CIRCULATION 60(2):110, 1979. 7. Badke FR, Walsh RA, Crawford MH, O'Rourke RA. Differential effects of N-acetyl

procainamide and procainamide on left ventricular performance in conscious dogs. CLIN RES 27(5):724A, 1979.

8. Shepherd AMM, Musgrove GE, Badke FR, Walsh RA. Tachycardia associated with

hydralazine pyruvic acid hydrazone, the major plasma metabolite of hydralazine. FEDERATION PROC 39: 1190, 1980.

9. Badke FR, Walsh RA, Crawford MH, O'Rourke RA. Hemodynamic effects of N-acetyl

procainamide in conscious dogs. CIRCULATION 62(3):292, 1980. 10. Walsh RA, Bishop VS, Horwitz LD. Beta receptor stimulated increases in regional

myocardial flow without changes in regional function in conscious dogs. CIRCULATION 62(3):110, 1980.

11. Walsh RA, Badke FR, O'Rourke RA. Differential effects of intracoronary calcium

antagonists on regional shortening in conscious dogs. CIRCULATION 62(3):10, 1980.

Richard A. Walsh, M.D. Bibliography(Continued) Page 24 12. Walsh RA, Crawford MH, O'Rourke RA. Relative sensitivity of echocardiography and

systolic time intervals to assess acute positive inotropic interventions. CIRCULATION 62(3):198, 1980.

13. Porter CB, Walsh RA, Badke FR, O'Rourke RA. Differential effects of a calcium

antagonist and vasodilator on left ventricular function in chronic volume overload. CIRCULATION 64(3):176, 1981.

14. Walsh RA, Porter C, Starling MR, O'Rourke RA. Salutory hemodynamic effects of

intravenous and oral diltiazem in severe congestive heart failure. CIRCULATION 66(2):138, 1981.

15. Walsh RA, O'Rourke RA. Absence of positive inotropic action in response to

intracoronary hydralazine in conscious dogs. CLIN RES 28(2):815, 1981. 16. Starling MR, Dell'Italia LJ, Walsh RA, Little WC, Benedetto AR, Nusynowitz ML.

Importance of region-of-interest selection for estimating absolute left ventricular volumes by radionuclide angiography. CLIN RES 30:834A, 1982.

17. Starling MR, Dell'Italia LJ Walsh RA, Little WC, Benedetto AR, Nusynowitz ML.

Importance of attenuation correction for obtaining accurate radionuclide angiographic estimates of left ventricular volumes. CLIN RES 30:834A, 1982.

18. Nusynowitz ML, Benedetto AR, Starling MR, Dell'Italia LJ, Walsh RA. A new

correction method for first pass (FP) flow determination and application to calculation of regurgitant fraction (RF). J NUCL MED 24:88-89, 1983.

19. Walsh RA, Badke FR, Neal CA. Altered end-systolic stress volume relations produced by

chronic left ventricular pressure overload in the nonhuman primate. CLIN RES 31(2): 225A, 1983.

20. Starling MR, Dell'Italia LJ, Walsh RA, Little WC, Benedetto AR. Improved accuracy of

radionuclide angiographic left ventricular volume estimates using a simple attenuation correction. CIRCULATION 68(2):547, 1983.

21. Dell'Italia LJ, Starling MR, Walsh RA, Badke FR, Lasher JC, Blumhardt R. Validation of

attenuation corrected radionuclide angiographic estimates of absolute right ventricular volumes. CIRCULATION 68(2):546, 1983.

22. Walsh RA, O'Rourke RA. Comparative effects of calcium antagonists on the rate of

isovolumic left ventricular relaxation in awake dogs. CIRCULATION 68(2):546, 1983. 23. Starling MR, Walsh RA, Badke FR. Validation of axial oblique biplane cineangiographic

left ventricular volumes. CLIN RES 32:208A, 1984.

Richard A. Walsh, M.D. Bibliography(Continued) Page 25 24. Cleary FX, Walsh RA, O'Rourke RA. Relative effects of calcium antagonists on exercise

hemodynamics in dogs. CIRCULATION 70(2): 234, 1984. 25. Kern M, Barr WK, Porter CB, Walsh RA, O'Rourke RA. Different coronary vasodilator

effects of nifedipine and diltiazem in patients with coronary artery disease. CIRCULATION 70(2):390, 1984.

26. Cleary FX, Walsh RA, O'Rourke RA. Effects of calcium entry blockade on ventricular

relaxation with exercise. CIRCULATION 70(2):355, 1984. 27. Starling MR, Dehmer GJ, Walsh RA, Weiland FJ, Blumhardt R. Relative value of

quantitative SPECT vs planar thallium-201 myocardial imaging for evaluating chest pain in patients after saphenous vein bypass grafting. RADIOLOGY 153(P):315, 1984.

28. Starling MR, Dehmer GJ, Lancaster JL, Lasher JC, Walsh RA, Wieland FJ, Blumhardt R.

Comparison of quantitative SPECT vs planar thallium-201 myocardial scintigraphy for detecting and localizing segmental coronary artery disease. J AM COLL CARDIOL 5:31, 1985.

29. Lasher JC, Starling MR, Walsh RA, Lancaster JL, Blumhardt R. Fourier analysis of left

ventricular gated blood pool radionuclide images: Mechanisms of phase shift induced by ischemia in pre-instrumented dogs. J NUCL MED 26:323, 1985.

30. Starling MR, Walsh RA, Dell'Italia LJ, Blumhardt R. Maximum time-varying elastance

(Emax) and Vo determined in man using equilibrium radionuclide angiography. CIRCULATION 72(3):480, 1985.

31. Walsh RA, Freeman GL, Cragg D, Crawford M, Shade R. Load independent impaired

ventricular relaxation in hypertrophied baboons. CIRCULATION 72(3):485, 1985. 32. Walsh RA, Cragg D, Freeman GL, Crawford MH, Shade R. Contractile depression

produced by chronic pressure overload hypertrophy in the nonhuman primate. CIRCULATION 72(3):5, 1985.

33. O'Rourke RA, Walsh RA. Relative effects of equihypotensive calcium antagonists on

coronary blood flow in awake dogs. CIRCULATION 72(3):314, 1985. 34. Starling MR, Walsh RA, Dell'Italia LJ, Lasher JC, Lancaster JL. Relation of various

measures of end-systole to left ventricular maximum time-varying elastance in man. J AM COLL CARDIOL 7(2):34A, 1986.

Richard A. Walsh, M.D. Bibliography(Continued) Page 26 35. Starling MR, Walsh RA, Lasher J, Lancaster J, Blumhardt R. Quantitation of left

ventricular regional wall motion abnormalities induced by ischemia using RNA phase analysis: Validation compared to left ventricular regional segment crystals in preinstrumented dogs. J AM COLL CARDIOL 5:389, 1985.

36. Starling MR, Walsh RA. Load dependence of the maximum stress-volume ratio in man.

CLIN RES 34(2):346A, 1986. 37. Walsh RA, Cragg DE, Freeman GL, Crawford MH, Shade R. Does regression of pressure

overload hypertrophy alter cardiac mechanics in the nonhuman primate? CLIN RES 34(2):352A, 1986.

38. Walsh RA, Crawford MH, Cragg D, Freeman GL, Shade R. Validation of

echocardiographic and biplane cineventriculographic left ventricular mass determination in normal and hypertensive baboons. CLIN RES 34(2):488A, 1986.

39. Cragg D, Shade R, Walsh RA, Carey K. Blood pressure, heart rate and hormonal

responses to reversal of hypertension in baboons with LVH. FEDERATION PROC 45:899, 1986.

40. Latham RD, Rubal BJ, Walsh RA, Westerhof N. A nonhuman primate model for the

critical evaluation of regional wave travel and reflections along the aorta. PROCEEDINGS OF INTERNATIONAL UNION OF PHYSIOLOGICAL SCIENCES 26:492, 1986.

41. Starling MR, Mancini GBJ, Gross MD, Walsh RA, Blumhardt R. Radionuclide

determination of the relationship between left ventricular contractile function and ejection fraction. CLIN RES 34(4):946A, 1986.

42. Starling MR, Mancini GBJ, Montgomery DG, Walsh RA. Load independence of left

ventricular isovolumic relaxation in normal man. CLIN RES 34(4):946A, 1986. 43. Starling MR, Mancini J, Gross MD, Walsh RA, Blumhardt R. Relationship of left

ventricular contractile function to ejection fraction assessed using radionuclide angiography in man. CIRCULATION 74(2):4, 1986.

44. Crawford MH, Walsh RA, Cragg D, Freeman GL, Miller JF. Comparative accuracy of

echo and angiographic left ventricular mass in baboons. CIRCULATION 74(2):179, 1986.

45. Applegate RJ, Walsh RA, O'Rourke RA. Negative force-frequency relationship after

verapamil during incremental atrial pacing. CIRCULATION 74(2):168, 1986.

Richard A. Walsh, M.D. Bibliography(Continued) Page 27 46. Shade RE, Walsh RA, Freeman GL, Carey KD. Baroreflex control of heart rate after

reversal of renal hypertension in the baboon with left ventricular hypertrophy. CIRCULATION 74(2):436, 1986.

47. Freeman GL, Walsh RA, Crawford MH, Cragg D. Long term hemodynamic effects of

hypertrophy regression in baboons. CIRCULATION 74(2): 288, 1986. 48. Applegate RJ, Walsh RA, O'Rourke RA. Failure of nifedipine to improve relaxation

during global ischemia in the conscious dog. CLIN RES 35(1):34A, 1987. 49. Starling MR, Mancini JGB, Montgomery DG, Walsh RA. Left ventricular isovolumic

relaxation is independent of loading conditions in normal man. J AM COLL CARDIOL 9(2):40A, 1987.

50. Dell'Italia LJ, Walsh RA. Application of a time varying elastance model to the right

ventricle in man: Do other measures of end-systole approximate Emax? CLIN RES 35(3):571A, 1987.

51. Applegate RJ, Walsh RA, O'Rourke RA. Effect of calcium entry blockade on relaxation

during acute ischemia in the conscious dog. CLIN RES 35(3):257A, 1987. 52. Dell'Italia LJ, Walsh RA, Applegate RJ. Effects of intravenous metoprolol on ventricular

function in Class III acute myocardial infarction. CLIN RES 35(3):274A, 1987. 53. Crawford MH, Cragg D, Freeman GL, Walsh RA. Effects of hypertrophy regression on

diastolic function in a hypertensive baboon model. CIRCULATION 76(4):530, 1987. 54. Latham RD, Rubal BJ, Sipkema P, Westerhof N, Virmani R, Rabinowitz M, Walsh RA.

Regional arterial dynamics in the chronically hypertensive baboon: Correlation with cardiovascular structural adaptation. CIRCULATION 76(4):442, 1987.

55. Applegate RJ, Walsh RA, O'Rourke RA. Diastolic function during demand-induced and

supply-limited ischemia. CIRCULATION 76(4): 426, 1987. 56. Dell'Italia LJ, Walsh RA. Right ventricular diastolic pressure volume relations: A

mechanism for acute changes. CIRCULATION 76(4):549, 1987. 57. Latham RD, Walsh RA, Rubal B, Sipkema P. Westerhof N. Ventricular/vascular coupling

dynamics in a chronically hypertensive baboon model. J AM COLL CARDIOL 11(2):93A, 1988.

58. Walsh RA, VandeBerg JF, Cragg D, Freeman GL, VandeBerg JL. Left ventricular

collagen distribution in baboons with chronic pressure overload hypertrophy and hypertrophy regression. FEDERATION PROC 2(4):A828, 1988.

Richard A. Walsh, M.D. Bibliography(Continued) Page 28 59. Konz KH, Haap M, Hill KE, Burk RF, Walsh RA. Oxidant stress produces selective

diastolic dysfunction in perfused selenium-deficient rat hearts. FEDERATION PROC 2(4):A817, 1988.

60. Shade RE, Walsh RA. Neurohumoral responses to chronic blood pressure reduction in

renal hypertensive baboons. FEDERATION PROC 2(6):A1716, 1988. 61. Henkel RD, VandeBerg JL, Shade RE, Torres MM, Walsh RA. Cardiac beta-myosin

heavy chain heterogeneity in hypertensive baboons. CIRCULATION 78(4):563, 1988. 62. Miller DD, Heyl BL, Walsh RA. Lung uptake of technetium-99m hexamibi isonitrile

during acute reversible ischemic left ventricular dysfunction in conscious dogs. CIRCULATION 78(4):386, 1988.

63. Hixson JE, Britten ML, Vernier DT, deLemos RA, Walsh RA. Cardiac myosin heavy

chain genes and gene transcription in cardiac tissues from adult, fetal, and prematurely delivered baboons. Presented AHA Conference on Hypertrophy, Big Sky, Wyoming, July 1988.

64. Shade RE, Walsh RA. Maintenance of baroreflex gain with 2K-1C hypertension in the

baboon. FEDERATION PROC 3(3):A851, 1989. 65. Miller DD, Heyl B, Canales M, Blumhardt R, Walsh RA. Discordant hemodynamic

disturbances with a common imaging result: increased lung uptake of technetium-99M hexamibi isonitrile. J NUCL MED 30:860, 1989.

66. Miller DD, Canales M, Salinas F, Escobedo D, Walsh RA. Time-averaged phosphorus-31

NMR spectroscopy of the metabolic response to hemodynamically equivalent pacing-induced and flow-limited ischemia in the conscious dog. J AM COLL CARDIOL 13(2):219A, 1989.

67. Konz HK, Haap M, Hill KE, Burk RF, Walsh RA. A model for congestive heart failure:

selenium and vitamin E deficient minipigs. J AM COLL CARDIOL 13(2):208A, 1989. 68. Miller DD, Salinas F, Canales M, Escobedo D, Walsh RA. Simultaneous cardiac

mechanics and myocardial phosphorus-31 NMR energetics during global ischemia & reperfusion in the closed-chest conscious dog. J AM COLL CARDIOL 13(2):200A, 1989.

69. Miller DD, Salinas F, Walsh RA. In vivo phosphorus-31 NMR spectroscopy of abnormal

myocardial energetics during stress in hypertrophied baboon hearts. CIRCULATION 80(4):II-588, 1989.

Richard A. Walsh, M.D. Bibliography(Continued) Page 29 70. Salinas F, Walsh RA, Escobedo D, Miller DD. Depth localized in vivo phosphorus-31

NMR spectroscopy in hypertensive baboons. Oral presentation 7th Annual Meeting of the Society For Magnetic Resonance Imaging, Los Angeles, March 1989.

71. Miller DD, O'Rourke RA, Walsh RA. Mechanisms of the favorable effects of calcium

entry blockade on high energy phosphate metabolism and left ventricular performance during post-ischemic reperfusion in the intact circulation. J AM COLL CARDIOL 15(2):209A, 1990.

72. Hoit BD, McMannis K, Gabel M, Shao Y, Walsh RA. Influence of left atrial pressure on

pulmonary venous flow. CLIN RES 39(2):202A, 1991. 73. Duldner JE, Ball N, Walsh RA. Effects of thyroid hormone on left ventricular mechanics

in isolated guinea pig hearts. CLIN RES 39(2):347A, 1991. 74. Walsh RA, Henkel R, Robbins J. Cardiac myosin heavy and light chain gene expression

in hypertrophy and heart failure. J MOL CELL CARDIOL 23(III): S18, 1991. 75. Hoit BD, Shao Y, Gabel M, Walsh RA. Influence of myocardial contractile dysfunction

on the pattern of pulmonary venous flow. CIRCULATION 84(4):369, 1991. 76. Hoit BD, Shao Y, Gabel M, Walsh RA. Influence of loading conditions and myocardial

contractile function on the pattern of pulmonary venous flow. CLIN RES 39(3):693A, 1991.*

77. Hoit BD, Shao Y, Millard RW, Gabel M, Prater L, Walsh RA. Concordance of regional

atrial microcirculatory flux and atrial microsphere blood flow. CLIN RES 39(3):693A, 1991.

78. Walsh RA. Cardiac myosin heavy- and light-chain gene expression in pressure-overload

hypertrophy: Cardiac biochemical and mechanical relations. Oral presentation Association of University Cardiologists Annual Meeting, January 1992.

79. Sakai H, Ball N, Brooks EE, Kreishman GP, Walsh RA. Myocardial stunning in

hypertrophied guinea-pig heart after inotropic stimulation: A 31-P NMR study. J AM COLL CARDIOL 19(3):318A, 1992.*

80. Hoit BD, Gabel M, Shao Y, Walsh RA. Differential regional atrial distensibility. J AM

COLL CARDIOL 19(3):387A, 1992.* 81. Hoit BD, Bauer B, Shao Y, Gabel M, Kinoshita A, Urata H. Hussain A, Walsh RA.

Hemodynamic effects of an angiotensin II-forming chymase in conscious baboons. CLIN RES 40:315A, 1992.

Richard A. Walsh, M.D. Bibliography(Continued) Page 30 82. Blankenship DC, Bhat G, Walsh RA. Pericardial effusions after cardiac transplantation.

Accepted for presentation - Society for Heart Transplantation 12th Annual Meeting and Scientific Sessions, April 1992.

83. Garrido JM, Gerson MC, Hoit BD, Gabel M, Walsh RA. Load independence of

radionuclide diastolic filling parameters. CLIN RES 40(2):401A, 1992. 84. Walsh RA, Ball NA, Bauer BJ. Cardiac mechanics and myosin heavy chain isoform

switches in a new model of pressure-overload hypertrophy. CLIN RES 40(2):220A, 1992.*

85. Ball NA, McLaughlin MK, Davidge ST, Walsh RA. Pregnancy enhances myocardial

contractile function in isolated rat hearts. CLIN RES 40(2):363A, 1992.* 86. Gerdes AM, Clark LC, Bauer BJ, Ball NA, Walsh RA. Volume overload hypertrophy

produces contractile depression and increased biventricular beta myosin heavy chain expression in rat heart. CLIN RES 40(2):435A, 1992.

87. Hoit BD, Shao Y, Gabel M, Walsh RA. Influence of the pericardium on left atrial

compliance and function. CLIN RES 40(2):365A, 1992.* 88. Hoit BD, Bauer B, Shao Y, Gabel M, Kinoshita A, Urata H, Husain A, Walsh RA.

Hemodynamic effects of an angiotensin II-forming chymase in conscious baboons. CLIN RES 40(2):315A, 1992.*

89. Gerson MC, Millard RW, Roszell N, Gabel M, Blankenship D, Mallin W, Washburn LC,

Biniakiewicz D, Walsh RA, Deutsch EA. Relationship of Tc-99m Q12 activity to myocardial blood flow in the canine heart. J NUCL MED 33:993, 1992.

90. Sakai H, Dorn GW, Ball N, Walsh RA. Contractile dysfunction in isolated myocytes from

pressure overload hypertrophied guinea-pig left ventricle. CIRCULATION 86(4):3334, 1992.

91. Hoit BD, Shao Y, Gabel M, Bauer B, Urata H, Husain A, Walsh RA. Hemodynamic

effects of an angiotensin II-forming chymase in conscious baboons with high renin hypertension. CIRCULATION 86(4):1723, 1992.

92. Hoit BD, Shao Y, Tsai LM, Patel R, Gabel M, McMannis K, Walsh RA. Influence of left

atrial compliance on left atrial and ventricular filling. CIRCULATION 86(4):2206, 1992. 93. Gerson MC, Millard RW, Roszell NJ, Gabel M, Blankenship DC, Mallin WH, Washburn

LC, Biniakiewicz D, Deutsch EA, Walsh RA. Myocardial kinetics of Tc-99m Q12 in dogs. CIRCULATION 86(4):2817, 1992.

Richard A. Walsh, M.D. Bibliography(Continued) Page 31 94. Gibler WB, Walsh RA, Levy RC, Runyon JP. Rapid diagnostic and treatment center in

the emergency department for patients with chest pain. CIRCULATION 86(4):56, 1992.* 95. Shao Y, Walsh RA, McMannis K, Gabel M, Hoit BD. Determination of left atrial volume

using sonomicrometry: A cast validation study. CLIN RES 40(3):682A, 1992.* 96. Hoit BD, Shao Y, Gabel M, Walsh RA. Time varying elastance of the intact left atrium. J

AM COLL CARDIOL 21(2):411A, 1993.* 97. Hoit BD, Shao Y, Gabel M, Walsh RA. Assessment of left atrial contractile performance

using a time varying elastance model. CLIN RES 41(2):230A, 1993.* 98. Hoit BD, Shao Y, Gabel M, Walsh RA. Systolic and diastolic function in conscious

baboons with early pressure overload hypertrophy. CLIN RES 41(3):633A, 1993. 99. Gerson MC, Millard RW, McGoron AJ, Gabel M, Washburn LC, Biniakiewicz D,

Deutsch EA, Elder RC, Walsh RA. Myocardial uptake & kinetics of Tc-99M Q3 in dogs. First International Congress of Nuclear Cardiology 602, 1993.

100. Gerson MC, Lukes J, Deutsch EA, Biniakiewicz D, Washburn LC, Lenihan DJ, Elder RC,

Walsh RA. Comparison of Tc-99m Q3 and T1-201 for detection of coronary disease in man. J NUCL MED 34(5):120P, 1993.

101. Gerson MC, Burwinkel P, Tseng C-Y, Bhat G, Johnson L, Walsh RA. Lung/heart ratio

from dipyridamole thallium images predicts coronary artery disease following cardiac transplantation. J NUCL MED 34(5):153P, 1993.

102. Gibler WB, Hull DM, Levy RC, Kacich R, Hamilton C, Walsh RA. Evaluation of

cocaine-induced chest pain in an emergency department (ED) rapid diagnostic and treatment unit. ANN EMERG MED 22(5):926, 1993.*

103. Gibler WB, Stewart GL, Levy RC, Nielsen MM, Kacich R, Hamilton C, Walsh RA.

Serial electrocardiograms (SerECGs) are useful for identifying patients with potential ischemic heart disease arrest in the emergency department (ED). ANN EMERG MED 22(5):922, 1993.

104. Hoekstra JW, Gibler WB, Levy RC, Sayre M, Naber W, Flinn M, Kacich R, Walsh RA.

Emergency department (ED) diagnosis of acute myocardial infarction (AMI) and ischemia: A cost analysis. ANN EMERG MED 22(5):941, 1993.*

105. Hoit BD, Burwig S, Bhat G, Walsh RA. Influence of a novel inotropic agent (OPC

18790) on hemodynamics and mechanics in patients with heart failure. CIRCULATION 88(4):235, 1993.*

Richard A. Walsh, M.D. Bibliography(Continued) Page 32 106. Kiss E, Ball NA, Kranias EG, Walsh RA. Altered cardiac mechanics and sarcoplasmic

reticulum function in pressure-overload hypertrophy with congestive heart failure. CIRCULATION 88(4):451, 1993.*

107. Hoit BD, Shao Y, Husain A, Gabel M, Walsh RA. Direct effects of chymase generated

angiotensin II upon normal and hypertrophied baboon hearts. CIRCULATION 88(4):625, 1993.*

108. Hoit BD, Shao Y, Gabel M, Drugan J, Walsh RA. Left atrial myosin heavy chain isoform

switches and function in canine cardiomyopathic heart failure. CIRCULATION 88(4):1313, 1993.*

109. Shao Y, Gabel M, Hoit BD, Walsh RA. Effect of altered load on in vivo left atrial

elastance determinations. CLIN RES 42:324A, 1994.* 110. Gerson MC, Lukes J, Deutsch E, Biniakiewicz D, Fortman C, Washburn LC, Walsh RA.

Comparison of Tc-99m Q12 and T1-201 imaging for detection of angiographic coronary artery disease. J AM COLL CARDIOL 23:255A, 1994.

111. Gerson MC, Lukes J, Deutsch E, Biniakiewicz D, Fortman C, Washburn LC, Walsh RA.

Comparison of Tc-99m Q12 and T1-201 imaging for detection of angiographic coronary artery disease. J AM COLL CARDIOL 23:255A, 1994.

112. Hoit BD, Shao Y, Gabel M, Walsh RA. Left atrial pressure-volume work is increased in

pacing tachycardia-induced cardiomyopathy. CLIN RES 42(3):369A, 1994.* 113. Collins JF, Dorn GW II, Walsh RA. Increased titin gene expression in guinea-pig

pressure overload left ventricular hypertrophy. CLIN RES 42(2):167A, 1994.* 114. Shao Y, Gabel M, Hoit BD, Walsh RA. Effect of altered load on in vivo left atrial

elastance determinations. CLIN RES 42(2):324A, 1994. 115. Hoit BD, Shao Y, Gabel M, Walsh RA. Left atrial chamber compliance and reservoir

function are decreased in pacing tachycardia-induced heart failure. CLIN RES 42(3):368A, 1994.*

116. Hoit BD, Dave V, Shao Y, Gabel M, Periasamy M, Walsh RA. Sarcoplasmic reticulum

gene expression and cardiac mechanics in primate early pressure overload hypertrophy. CLIN RES 42(3):425A, 1994.*

117. Lenihan DJ, Gerson MC, Dorn GW, Hoit BD, Walsh RA. Influence of loading conditions

and contractile state on the atrioventricular gradient in diastolic heart failure in man. CIRCULATION 90(4):2123, 1994.*

Richard A. Walsh, M.D. Bibliography(Continued) Page 33 118. Hoit BD, Shao Y, Gabel M, Walsh RA. Left atrial pressure-volume work in canine

cardiomyopathy. CIRCULATION 90(4):2315, 1994. 119. Kadambi FJ, Walsh RA, Ponniah S, Dorn GW II, Kranias EG. Overexpression of

phospholamban in the mouse results in prolongation of Ca2+ transients and depressed contractility in isolated cardiomyocytes. CIRCULATION 90(4):2894, 1994.

120. Dave V, Hoit BD, Shao Y, Gabel M, Periasamy M, Walsh RA. Sarcoplasmic reticulum

gene expression and cardiac mechanics in primate early pressure overload hypertrophy. CIRCULATION 90(4):3593, 1994.

121. Khoury SF, Kranias EG, Ball N, Walsh RA, Hoit BD. In vivo noninvasive assessment of

left ventricular function in transgenic mice with phospholamban deficiency and overexpression. J AM COLL CARDIOL 727-6:134A, 1995.*

122. Lenihan DJ, Gabel M, Huth C, Walsh RA, Gerson MC. Reliability of Q12 and thallium

myocardial uptake measurements after triphenyl tetrazolium chloride staining. J AM COLL CARDIOL 962-121:217A, 1995.*

123. Song G, Gunteski-Hamblin AE, Dorn II GW, Kirkpatrick DL, Dedman JR, Walsh RA.

Depressed intracellular calcium homeostasis and mechanical properties of cardiomyocytes in annexin VI transgenic mouse. J AM COLL CARDIOL 766.5:277A, 1995.*

124. Lenihan DJ, Gerson MC, Nishiyama H, Dorn II GW, Walsh RA. Effects of changes in

atrioventricular gradient and isovolumic relaxation rates on radionuclide diastolic filling in man. J AM COLL CARDIOL 1007-21:358A, 1995.*

125. Gerson MC, Shao Y, Hoit BD, Gabel M, Walsh RA. Radionuclide assessment of left

ventricular active relaxation and load with regional myocardial ischemia. J NUCL CARDIOL 2(2):S71, 1995.*

126. Shao Y, Gerson MC, Hoit BD, Gabel M, Walsh RA. Effect of inotropic and load

conditions on radionuclide diastolic indices with pacing-induced cardiomyopathic heart failure. J INVEST MED 43(2):317A, 1995.*

127. Shao Y, Hoit BD, Gabel M, Walsh RA. Left atrial elastance determinations are

independent of the method used to alter loading conditions. J INVEST MED 43(2):319A, 1995.

128. Liao Y, Yi T, Hoit BD, Walsh RA, Karnik SS, Husain A. Transcriptional regulation of

the baboon mast cell chymase (b-chm) gene. Submitted American Society of Biochemistry and Molecular Biology, San Francisco, California, May 1995.

Richard A. Walsh, M.D. Bibliography(Continued) Page 34 129. Song G, Dorn II GW, Gunteski-Hamblin AME, Kirkpatrick DL, Dedman JR, Walsh RA.

Abnormal Na+/Ca2+ exchanger activity in transgenic mice which overexpress annexin VI. J MOL CELL CARDIOL 27(6):A133, 1995.*

130. Paul K, Ball NA, Dorn II GW, Walsh RA. The effects of stretch on phosphoinositol

hydrolysis in the transition from pressure overload hypertrophy to congestive heart failure. J INVEST MED 43(3):428A, 1995.*

131. Paul K, Ball NA, Dorn II GW, Walsh RA. Angiotensin mediates stretch induced

phosphoinositol hydrolysis in adult guinea pig hearts. J INVEST MED 43(3):451A, 1995.*

132. Khoury SF, Hoit BD, Shao Y, Gabel M, Liggett SB, Walsh RA. Differential cardiac

adrenergic subtype density and the sensitivity of left ventricular function to catecholamines in the thyrotoxic baboons. J INVEST MED 43(3):451A, 1995.*

133. Hoit BD, Khoury SF, Shao Y, Gabel M, Dave V, Periasamy M, Walsh RA. Enhancement

of the force-frequency relation by thyroid hormone is correlated with contractile and calcium cycling protein gene expression in conscious baboons. J INVEST MED 43(3):452A, 1995.*

134. Paul K, Ball NA, Dorn II GW, Walsh RA. Angiotensin mediates stretch induced

phosphoinositol hydrolysis in adult guinea pig hearts. CIRCULATION 92(8):0304, 1995.*

135. Hoit BD, Khoury SF, Shao Y, Gabel M, Dave V, Periasamy M, Walsh RA. Enhancement

of the force-frequency relation by thyroid hormone is correlated with contractile and calcium cycling protein gene expression in conscious baboons. CIRCULATION 92(8):1211, 1995.*

136. Song G, Kirkpatrick DL, Dorn II GW, Palermo J, Robbins J, Walsh RA. Unchanged

intracellular calcium levels and depressed mechanical properties of cardiomyocytes in myosin light chain transgenic mice. CIRCULATION 92(8):1527, 1995.*

137. Paul K, Ball NA, Dorn II GW, Walsh RA. The effects of stretch on phosphoinositol

hydrolysis in the transition from pressure overload hypertrophy to congestive heart failure. CIRCULATION, 92(8):2510, 1995.*

138. Khoury SF, Hoit BD, Shao Y, Gabel M, Liggett S, Walsh RA. Differential cardiac

adrenergic subtype density and the sensitivity of left ventricular function to catecholamines in thyrotoxic baboons. CIRCULATION 92(8):3206, 1995.*

Richard A. Walsh, M.D. Bibliography(Continued) Page 35 139. Song G, Kirkpatrick DL, Gunteski-Hamblin AE, Dorn II GW, Dedman JR, Walsh RA.

Abnormal Na+/Ca2+ exchanger activity in transgenic mice with cardiac specific overexpression of annexin VI. CIRCULATION 92(8):3350, 1995.*

140. Lenihan DJ, Gerson MC, Gabel M, Huth C, McGoron AJ, Walsh RA. Influence of

stunned but viable myocardium on Q12 and thallium uptake after reperfusion in canine myocardial infarction. CIRCULATION 92(8):3797, 1995.*

141. Song G, Kirkpatrick DL, Dorn II, GW, Robbins J, Walsh RA. Decreased calcium

sensitivity: A reason for depressed mechanical properties of cardiomyocytes from myosin light chain overexpression transgenic mice. J AM COLL CARDIOL 27(2):31A, 1996.*

142. Hoit BD, Khan Z, Ball N, Kadambi VJ, Kranias EG, Walsh RA. Echocardiographic

assessment of left ventricular systolic function in transgenic mice with cardiac specific over-expression of phospholamban. J AM COLL CARDIOL 27(2):50A, 1996.*

143. Khan Z, Dahm C, Walsh RA, Hoit BD. In vivo determination of left ventricular stress

shortening relations in mice using echocardiography. J AM COLL CARDIOL 27(2):267A, 1996.*

144. Hoit BD, Shao Y, Gabel M, Kirkpatrick DL, Paul K, Walsh RA. Left atrial biochemical

and mechanical changes after regression of rapid pacing induced heart failure: Relation to left ventricular function. J AM COLL CARDIOL 27(2):323A, 1996.*

145. Hoit BD, Kranias EG, Walsh RA. Noninvasive cardiac functional analysis of genetically

altered mice using imaging and Doppler echo. J MOL CELL CARDIOL 28(6):S68, 1996.

146. Walsh RA, Periasamy M, Hoit B. Effects of thyroid hormone on force frequency relations

myosin heavy chains and calcium cycling proteins in the baboon. J MOL CELL CARD 28(6):S38, 1996.

147. Khan Z, Gabel M, Millard RW, Walsh RA, Hoit BD. Altered abdominal aortic

compliance and vasodilator responses in canine pacing-induced heart failure. J INVEST MED 44(7):351A, 1996.*

148. Hoit BD, Shao Y, Pawloski-Dahm CM, Gabel M, Walsh RA. Left ventricular

biochemical and mechanical effects of a thyroid hormone analog in baboons. J INVEST MED 44(7):376A, 1996.*

149. Paul K, Ball N, Dorn GW, Walsh RA. Stretch-mediated PKC isoform translocation in the

transition from pressure overload hypertrophy to congestive heart failure. J INVEST MED 44(7):391A, 1996.*

Richard A. Walsh, M.D. Bibliography(Continued) Page 36 150. Wagoner LE, Hoit BD, Hedger VH, Donnelly E, Bhat G, Walsh RA, Liggett SB.

Polymorphisms of the 2 adrenergic receptor (2AR) affect exercise capacity in patients with heart failure. J INVEST MED 44(7):394A, 1996.*

151. Shao Y, Gabel M, Khan Z, Walsh RA, Hoit BD. Characterization of left atrial reservoir,

conduit and booster pump functions in a novel model of isolated atrial myopathy. J INVEST MED 44(7):394A, 1996.*

152. Paul K, Ball N, Dorn GW, Walsh RA. Effects of mechanical stretch, angiotensin II and

phorbol ester stimulation on PKC isoform distribution in adult guinea pig hearts. J INVEST MED 44(7):398A, 1996.*

153. Hoit BD, Shao Y, Pawloski-Dahm CM, Gabel M, Walsh RA. Left ventricular

biochemical and mechanical effects of a thyroid hormone analog in baboons. CIRCULATION 94(8):0380, 1996.*

154. Khan Z, Gabel M, Millard RW, Walsh RA, Hoit BD. Altered abdominal aortic

compliance and vasodilator responses in canine pacing-induced heart failure. CIRCULATION 94(8):0810, 1996.*

155. Paul K, Ball NA, Pawloski-Dahm CM, Dorn GW II, Walsh RA. Effects of mechanical

stretch, angiotensin II and phorbol ester stimulation on differential PKC isoform distribution in adult guinea pig hearts. CIRCULATION 94(8):1656, 1996.*

156. Meleca MJ, McGoron AJ, Millard RW, Gabel M, Biniakiewicz, Walsh RA, Gerson MC.

Unique flow vs uptake characteristics of Tc99m-Q3 among five technetium tracers in a canine model of myocardial ischemia. CIRCULATION 94(8):1754, 1996.*

157. Chu G, Kadambi VJ, Luo W, Kirkpatrick DL, Walsh RA, Kranias EG. Cardiomyocyte

mechanics in transgenic mice expressing monomeric phospholamban. CIRCULATION 94(8):2449, 1996.*

158. Paul K, Dorn GW II, Ball NA, Pawloski-Eahm CM, Walsh RA. Stretch-mediated PKC

isoform translocation in the transition from pressure overload hypertrophy to congestive heart failure. CIRCULATION 94(8):3222, 1996.*

159. Wagoner LE, Hoit BD, Hedger VH, Donnelly E, Bhat G, Walsh RA, Liggett SB.

Polymorphisms of the 2 adrenergic receptor (2AR) affect exercise capacity in patients with heart failure. CIRCULATION 94(8):3926, 1996.*

160. Song G, Pawloski-Dahm CM, Kirkpatrick DL, Wagoner LE, Walsh RA. Cardiac

annexins are differentially regulated in human end-stage heart failure. CIRCULATION 94(8):4243, 1996.*

Richard A. Walsh, M.D. Bibliography(Continued) Page 37 161. Hoit BD, Shao Y, Gabel M, Walsh RA. Abnormalities of left atrial reservoir, conduit and

booster pump functions in a rapid pacing model of atrial myopathy. J AM COLL CARDIOL 29:213A, 1997.

162. Rosenbaum A, McGoron AJ, Gerson MC, Millard RW, Gabel M, Biniakiewicz D, Walsh

RA. Myocardial blood flow vs tracer uptake characteristics of perfusion tracers during dobutamine stress. J AM COL CARDIOL 29(2):442A, 1997.*

163. Rosenbaum AF, Lukes J, Biniakiewicz D, Fortman C, McGoron AJ, Walsh RA, Gerson

MC. Technetium-99m Q4 washout in human hearts. J NUCL MED 38(5):712, 1997. 164. Walsh RA, Dorn GW II, Hoit BD, King GL. Mechanotransduction in the normal,

hypertrophied, and failing adult heart. J MOL CELL CARDIOL 29:A25, 1997.* 165. Wagoner LE, Hoit BD, Hornung RW, Craft LL Walsh RA, Liggett SB. Genetic

polymorphisms of the human 2 adrenergic receptor (2AR) predict survival in patients with heart failure. CIRCULATION 96:504, 1997.*

166. Baker D, Reed T, Grupp IL, Grupp G, Bhagwat AR, Hoit BD, Walsh RA, Periasamy M.

Overexpression of the cardiac SR Ca2+ ATPase increases myocardial performance. CIRCULATION 96:764, 1997.*

167. Song G, Campos B, Wagoner LE, Dedman JR, Walsh RA. Transcriptional regulation of

the cardiac annexins in human end-stage heart failure. CIRCULATION 96:768, 1997.* 168. Hoit BD, Kadambi VJ, Ball N, Magorien D, Kranias EG, Walsh RA. Influence of

phospholamban on force-frequency relations and isovolumic indices of ventricular function in the closed chest mouse. CIRCULATION 96:3183, 1997.

169. Kumar A, McGoron AJ, Biniakiewicz DS, Kennedy SC, Millard RW, Walsh RA, Gerson

MC. Uptake of novel 99m Tc-Q compound in laminin attached adult rat cardiac myocytes. Submitted to Society of Nuclear Medicine 45th Annual Meeting, Toronto, Canada, June 1998.

170. McGoron AJ, Biniakiewicz DS, Gabel M, Huth C, Millard RW, Walsh RA, Gerson MC.

Kinetics of 99mTc-Q64 in a canine model of myocardial ischemia. Submitted to Society of Nuclear Medicine 45th Annual Meeting, Toronto, Canada, June 1998.

171. Bowling N, Estridge T, Fouts R, Song G, Roden R, Bristow M, Walsh RA, Sabbah H,

Sandusky G, Mizrahi J, Gromo G, Vlahos C. Increased protein kinase C expression in failing human heart. J AM COLL CARDIOL 31(2):203A, 1998.*

Richard A. Walsh, M.D. Bibliography(Continued) Page 38 172. Sakata Y, Hoit BD, Liggett SB, Walsh RA, Dorn GW II. Failure of pressure overload

hypertrophy in Gq overexpressing mice. J AM COLL CARDIOL 31(2):2A, 1998, Young Investigators Award*.

173. Takeishi Y, Chu G, Wakasaki H, Hoit BD, Kranias E, King GL, Walsh RA. Targeted

overexpression of protein kinase C 2 isoform in myocardium causes cardiomyopathy. Submitted to International Society for Heart Research, XVI World Congress, Rhodes, Greece, May 1998.

174. Vlahos CJ, Estridge T, Mizrahi J, Song G, Walsh RA, Bowling N. Protein kinase C in the

heart: a target for the treatment of heart failure? Submitted to International Society for Heart Research, XVI World Congress, Rhodes, Greece, May 1998.

175. Hoit BD, Kadambi VJ, Ball N, Magorien D, Walsh RA. In vivo strain-dependent

contractility and force frequency relations in mice. Submitted to International Society for Heart Research, XVI World Congress, Rhodes, Greece, May 1998.

176. Periasamy M, Loukianov E, Baker D, Ji Y, Grupp I, Grupp G, Walsh RA. Transgenic

manipulations of SR CA2+ ATPase levels in the mouse heart. Submitted to International Society for Heart Research, XVI World Congress, Rhodes, Greece, May 1998.

177. Kadambi VJ, Sato Y, Ball N, Kranias EG, Walsh RA, Hoit BD. Transgenic

overexpression of calsequestrin produces pulsus alternans in vivo. Submitted to International Society for Heart Research, XVI World Congress, Rhodes, Greece, May 1998.

178. Sato Y, Kadambi VJ, Ball N, Hoit BD, Walsh RA, Kranias EG. Calsequestrin

overexpression produces left ventricular hypertrophy and increased fractional shortening. Submitted to International Society for Heart Research, XVI World Congress, Rhodes, Greece, May 1998.

179. McGoron AJ, Biniakiewicz DS, Gabel M, Huth C, Millard RW, Walsh RA, Gerson MC.

Kinetics of 99mTc-Q64 in a canine model of myocardial ischemia. J NUCL MED 39:216P, 1998.

180. Kumar A, McGoron AJ, Biniakiewicz DS, Kennedy SC, Millard RW, Walsh RA, Gerson

MC. Uptake of novel 99m Tc-Q compounds in laminin attached adult rat cardiac myocytes. J NUCL MED 39:216P, 1998.

181. Takeishi Y, Chu G, Kirkpatrick DL, Kranias EG, King GL, Walsh RA. In vivo

phosphorylation of cardiac troponin I by PKC2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts. Submitted to Heart Failure Society of America annual meeting, Boca Raton, FL, September, 1998.

Richard A. Walsh, M.D. Bibliography(Continued) Page 39 182. Hoit BD, Kadambi VJ, Ball N, Banerjee A, Kranias EG, Walsh RA. In vivo modulation

of mechanical restitution in genetically engineered mice with altered levels of phospholamban. Submitted to the Midwestern Central Society for Clinical Research annual meeting, Chicago, IL, September, 1998.

183. Suresh DP, Craft L, Liggett SB, Walsh RA, Hoit BD. A 2 receptor polymorphism

influences agonist-stimulated peripheral blood flow in normal individuals. Submitted to the Midwestern Central Society for Clinical Research annual meeting, Chicago, IL, September, 1998.

184. Kadambi VJ, Ball N, Banerjee A, Kranias EG, Walsh RA, Hoit BD. Genetically altered

phospholamban levels modulate the rate of mechanical restitution In vivo. CIRCULATION 98:734, 1998.

185. Suresh DP, Craft L, Liggett SB, Walsh RA, Hoit BD. A 2 receptor polymorphism

influences agonist-stimulated peripheral blood flow in normal individuals. CIRCULATION 98:2069, 1998.

186. Loukianov EV, Yong J, Grupp IL, Walsh RA, Periasamy M. Targeted overexpression of

the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+ ATPase (SERCA1a) in the heart produces significantly enhanced myocardial performance. CIRCULATION 98:2138, 1998.

187. Takeishi Y, Thunder J, Ball NA, Walsh RA. Oxidative stress produces differential

activation of protein kinase C isoforms in adult guinea pig hearts. CIRCULATION 98:2224, 1998.

188. Storrow AB, Gibler WB, Walsh RA, Liu T, Hamilton CA, Brennan T. An emergency

department chest pain rapid diagnosis and treatment unit: results from a six year experience. CIRCULATION 98:2235, 1998.

189. Jalili T, Song G, Paul K, Takeishi Y, Ball NA, Walsh RA. Phospholipase c activation and

protein kinase c activity are enhanced during pressure overload cardiac hypertrophy and congestive heart failure in the adult guinea pig. CIRCULATION 98:3561, 1998.

190. Tramuta DA, Kadambi V, Ball N, Dash R, Kranias EG, Walsh RA, Hoit BD. New

insights into calcium cycling using post-extrasystolic potentiation in phospholamban overexpression. J AM COLL CARDIOL 33(2):515A, 1999.

191. Takeishi Y, Abe J, Lee J, Walsh RA, Berk BC. Differential Regulation of p90RSK and

BMK1 by Ischemia/Reperfusion and Oxidative Stress in Perfused Guinea Pig Hearts. CIRCULATION 100:1351, 1999.

Richard A. Walsh, M.D. Bibliography(Continued) Page 40 192. Takeishi Y, Abe J, Lee, J, Walsh RA, Berck BC. Ischemic Preconditioning Alters

p90RSK and BMK1 Activation After Ischemia/Reperfusion. CIRCULATION 100:1704, 1999.

193. Takeishi Y, Jalili T, Kirkpatriack DL, Wagoner LE, Abraham WT, Walsh RA.

Differential Alterations in Ca2+ Cycling and Gq Signaling Proteins After Left Ventricular Assist Device Support in Failing Human Hearts. CIRCULATION 100:2204, 1999.

194. Baines CP, Huang Q, Takeishi Y, King GL, Walsh RA, Abe JI. Activation of p90

ribosomal S6 kinase in murine hearts overexpressing protein kinase C II but not protein kinase C . CIRCULATION 102:332, 2000.

195. Takeishi Y, Huang Q, Abe JI, Che W, Lawrence EG, Hoit BD, Walsh RA. Differential

activation of mitogen-activated protein (MAP) kinase family and P90 ribosomal S6 kinase (RSK) in hypertrophied myocardium induced by pressure-overload. CIRCULATION 102:335, 2000.

196. Kiatchoosakun S, Kirkpatrick D, Olszens K, Nadeau JH, Walsh RA, Hoit BD. Naturally

occurring variation in inbred mouse strains: a mouse model of the athlete's heart. CIRCULATION 102:944, 2000.

197. Huang Q, Takeishi Y, Che W, Baines CP, Yoshizumi M, Walsh RA, Abe JI. Src family

kinase and adenosine differentially regulate multiple MAP kinases in ischemic myocardium: modulation by ischemic preconditioning. CIRCULATION 102:1022, 2000.

198. Takeishi Y, Huang Q, Abe JI, Abraham WT, Wagoner LE, Hoit BD, Walsh RA.

Activation of multiple mitogen-activated protein kinases and P90 ribosomal S6 kinase in failing human hearts. CIRCULATION 102:2185, 2000.

199. Hoit B, Restivo JM, Kiatchoosakun S, Kirkpatrick D, Walsh RA, Rodrigue-Way A,

Acton S, Fordjour P, Breitbart RE, Kadambi VJ. Restrictive cardiomyopathy in transgenic mice with cardiac-specific overexpression of a tyrosine phosphatase, PRL-3. CIRCULATION 104:791, 2001.

Richard A. Walsh, M.D. Bibliography(Continued) Page 41 Research Interests - Keyword Descriptions: Primary - Ventricular function, basic and clinical; Mechanisms of Ventricular

Hypertrophy and Heart Failure. Secondary - Coronary blood flow, basic and clinical; Noninvasive evaluation of

ventricular function, Cardiovascular Imaging.