curriculum vitae paul r. carney, md - unc health care · williams & wilkins, inc.,...

CURRICULUM VITAE

Paul R. Carney, MD

Professor of Neurology, University of North Carolina at Chapel Hill Department of Neurology Phone: 919.966.1683 University of North Carolina at Chapel Hill Fax: 919.966.2922 170 Manning Drive, Campus Box 7025 Email: [email protected] Chapel Hill, North Carolina 27599-7025

EDUCATION

07/01/97 to 06/30/98 Neurophysiology/Clinical Epilepsy Fellowship, University of Michigan

07/01/97 to 06/30/98 Sleep Medicine Fellowship, University of Michigan

07/01/94 to 06/30/97 Child Neurology Fellowship, University of Michigan

07/01/92 to 06/30/94 Pediatric Residency, Case Western Reserve University, University Hospitals of Cleveland, Rainbow Babies and Children’s Hospital

03/30/83 to 12/30/90 M.D, University of Valparaiso School of Medicine

09/01/74 to 05/01/80 B.S., Chemistry, John Carroll University

CERTIFICATIONS AND LICENSURES

ABPN Neurology with Special Qualification in Child Neurology - Certificate No. 11544 (active)

North Carolina Medical License 2016-01430 (active)

Florida Medical License ME 76167 (active)

DEA schedule 2-5 license (active)

DEA schedule 1 researcher license (active)

NPI 1750327938 (active)

Michigan Medical State License (not active)

Ohio Medical State License (not active)

PROFESSIONAL EXPERIENCE – EMPLOYMENT HISTORY

Academic Appointments:

10/04/16 to present Graduate Faculty, Neuroscience Program University of North Carolina at Chapel Hill

09/01/02 to present Graduate Faculty, Interdisciplinary Programs

University of Florida Colleges of Medicine and Engineering

06/16/16 to present Professor of Neurology University of North Carolina at Chapel Hill

09/30/07 to 06/15/16 Wilder Endowed Chair Professor for Epilepsy Research University of Florida College of Medicine

07/01/07 to 06/15/16 Tenured Full Professor of Pediatrics and Neurology University of Florida College of Medicine

07/01/07 to 06/15/16 Joint Professor of Biomedical Engineering University of Florida College of Medicine

07/01/07 to 06/15/16 Affiliate Professor of Neuroscience University of Florida College of Medicine

09/01/05 to 06/30/07 Associate Professor with Tenure of Pediatrics and Neurology

Curriculum Vitae Paul R. Carney, MD

University of Florida College of Medicine

09/01/05 to 06/30/07 Affiliate Associate Professor of Neuroscience University of Florida College of Medicine

09/01/05 to 06/30/07 Joint Associate Professor of Biomedical Engineering University of Florida College of Engineering

07/01/98 to 08/01/05 Assistant Professor of Pediatrics and Neurology University of Florida College of Medicine

07/01/98 to 08/01/05 Affiliate Assistant Professor of Neuroscience University of Florida College of Medicine

07/01/98 to 08/01/05 Joint Assistant Professor of Biomedical Engineering University of Florida College of Engineering

03/01/91 to 06/30/92 Research Associate, University of Valparaiso School of Medicine

Administrative Appointments:

09/15/16 to present Director, Division of Pediatric Neurology Department of Neurology University of North Carolina at Chapel Hill

09/15/16 to present Fellowship Director, Division of Pediatric Neurology Department of Neurology, University of North Carolina at Chapel Hill

09/01/07 to 06/15/16 Director, Wilder Center of Excellence for Epilepsy Research University of Florida College of Medicine

09/01/10 to 06/15/12 Director, Pediatric Neurology Residency and Fellowship Program Department of Pediatrics, University of Florida College of Medicine

07/01/02 to 06/30/12 Director, Division of Pediatric Neurology Department of Pediatrics, University of Florida College of Medicine

08/15/01 to 06/30/02 Interim Director, Division of Pediatric Neurology Department of Pediatrics, University of Florida College of Medicine

Hospital/Clinical Medical Staff Appointments:

09/15/16 to present Medical Director, Pediatric Neurodiagnostics and Epilepsy Program University of North Carolina at Chapel Hill

09/15/16 to present Staff Physician, Pediatric Neurology, Epilepsy, Clinical Neurophysiology University of North Carolina Health Care System

07/01/98 to 06/15/16 Staff Physician, Epilepsy, Neurophysiology, and Sleep Medicine University of Florida Health Shands Hospital

07/01/98 to 06/15/15 Neurologist Staff Physician University of Florida Health Shands Hospital

07/01/99 to 06/30/12 Medical Director, Comprehensive Pediatric Epilepsy Program University of Florida Health Shands Hospital

07/01/99 to 06/30/12 Medical Director, Pediatric Neurodiagnostics Laboratory University of Florida Health Shands Hospital

01/01/91 to 06/30/92 Tertiary Care Community Outpatient Clinic General Physician V Region, Valparaiso, Chile

Administrative Highlights:

• Established the University of North Carolina Translational Neural Engineering Group, 2016-

• Established Florida Epilepsy Network, 2015-2016

• Established graduate level courses in the UF Departments of Pediatrics, Neuroscience and Biomedical Engineering, 2004-2016


• Established University of Florida Pediatric Epilepsy Center of Excellence, 2002-2016

• Established the University of Florida Epilepsy Research Laboratory, 1998-2016

• Pediatric Neurology Program top ranked in the US News and World Report – 2010, 2011, 2012

• UF Learning disorder state program - $900,000/year recurring funding, 2002-2012

• Established clinical centers of excellence in epilepsy, learning disorders, autism, sleep disorders, 2002-2012

• Established University of Florida Pediatric Neurology Fellowship - 2010

• Endowment – UF SOS to support epilepsy research - $75,000, 2010

• Endowment of UF B.J and Eve Wilder Professorship – 1M + 0.5M state match, 2008

• Endowment of UF Epilepsy Research Program – B.J. and Eve Wilder Gift, 2 M + 2 M state match, 2006

HONORS

Life Sciences and Healthcare Council Member, Gainesville Florida Chamber of Commerce, May, 2017

National Institutes of Health Acute Neural Injury and Epilepsy Study Section Member, July 01, 2017 to June 30, 2021

Elected Member, National Professional Advisory Board, Epilepsy Foundation of America, July 1, 2014 to June 30, 2017

Best Doctors in America Honorary Award, 2008, 2009 2010, 2011, 2012, 2013, 2014, 2015, 2016

B.J. and Eve Wilder Endowed Professor in Epilepsy Research, August, 2007 to June 15, 2016

Patients' Choice Award, 2011, 2012, 2013, 2014, 2015, 2016

Compassionate Doctor Award, 2011, 2012, 2013, 2014, 2015, 2016

International Association of Pediatricians ‘Top Pediatrician in Gainesville’ award, April 2014

Advisory Board, Epilepsy Foundation’s National Professional Advisory Board, March 2014

Elected Board Member, Epilepsy Foundation of America (Florida), August 2011 to June 2014

American Pediatric Society ‘Most Outstanding’ New Member Award, 2011

Elected Fellow, American Neurological Association, 2010

Fourth International Workshop on Seizure Prediction Committee, 2009

Faculty Research Prize in Clinical Science, University of Florida, 2009

Honorary Fellow, Chilean Child-Adolescent-Psychiatry-Neurology Society, 2006

The William Pierskalla ‘best paper award’ for research excellence, 2004

Elected Honorary Fellow, Society for Pediatric Research, 2000

Teaching Excellence Award, Department of Pediatrics, University of Florida, 1999

Elected Fellow, American Academy of Pediatrics, 1998

Doctor of Medicine with Honors, 1990

National Research Service Award, National Science Foundation, 1985

John Huntington Scholarship for Undergraduate Studies, John Carroll University, 1980

Diamond-Shamrock Corporation Cooperative Educational Scholarship, 1980


BIBLIOGRAPHY AND PRODUCTS OF SCHOLARSHIP

Books:

1. Paul R. Carney, James D. Geyer, Richard Berry. Clinical Sleep Disorders, 2nd Ed. Lippincott- Williams & Wilkins, Inc., Philadelphia, 2012.

2. Paul R. Carney and James D. Geyer. Clinical Neurophysiology: Methods and Clinical Applications. CRC Press. 2012.

3. Paul R. Carney and James D. Geyer JD. Pediatric Practice: Neurology, McGraw Hill Professional Pubs, 1st edition. 2010.

4. L. John Greenfield, James D. Geyer, and Paul R. Carney. Reading EEGs: A Practical Approach. 1st ed. Lippincott-Williams & Wilkins, Inc., Philadelphia 2010.

5. James D. Geyer, Daniel C. Potts, Edward E. Marsh, and Paul R. Carney. Neurology for Wards and Mini-Boards: The Complete Medical Student Guide. 1st ed. Lippincott-Williams & Wilkins, Inc., Philadelphia, 2009.

6. James D. Geyer, Paul R. Carney, Troy T. Payne. Atlas of Digital Polysomnography. 2nd Lippincott-Williams & Wilkins, Inc., Philadelphia, 2009.

7. James D. Geyer, Janice M. Keating, Daniel C. Potts, Paul R. Carney. Neurology for the Boards, 3rd ed. Lippincott-Williams & Wilkins, Inc., Philadelphia, 2006.

8. Paul R. Carney, James D. Geyer, Richard Berry, Clinical Sleep Disorders, 1st ed. Lippincott Williams & Wilkins, Inc., Philadelphia, 2005.

9. Pardalos PM, Sackellares JC, Carney PR., Iasemidis LD. In: Quantitative Neuroscience: Models, Algorithms, Diagnostics, and Therapeutic Applications. Kluver Academic Publishers, Norwell, MA 2004.

10. James D. Geyer, Paul R. Carney, Troy T. Payne, Michael Aldrich. Atlas of Digital Polysomnography. 1st ed. Lippincott-Williams & Wilkins, Inc., Philadelphia, 2000.

In Press/Submitted Books:

James D. Geyer, Paul R. Carney. Atlas of Digital Polysomnography. 3rd Ed. Lippincott-Williams & Wilkins, Inc., Philadelphia, to appear in 2017, 256 pages, in press.

Chapters:

1. Salardini A. Geyer JD, and Carney PR. Genetic Neurological Diseases in the Adult. In: The Hospital Neurology Book. Eds. Arash Salardini and Jose Biller. Chapter 37, McGraw Hill pub, pages 154-169, 2016.

2. Sprague-McRae, JM, Lee, JEM, Boyd JR, Carney PR, Leighty DD, Morrison LA, Rosenblum RK. Alterations of Consciousness New Patient Encounter Guide. In: Child Neurology Encounter Guides ACNN/CNS, Chapter 2, pages 92-127, 2014.

3. Geyer JD, Carney PR. REM Sleep Behavior. In: Common Pitfalls in Sleep Medicine: Case-Based Learning. Eds. Ronald D. Chervin, Cambridge University Press. pages 132-155, 2013.

4. Carney PR, Geyer JD, Tinuper P. Bisulli F, Provini F. Treating Epilepsy in the Presence of Sleep Disorders. Chapter 34, In: Medical and Surgical Treatment of Pediatric Epilepsy. Eds: Helen Cross, Michael Duchowny, Tracy Glauser, Edouard Hirsch, Alexis Arzimanoglou. McGraw-Hill Pubs, pages 155-182, 2012.

5. Jennifer Parr-Christmas, Monica M. Henderson, James D. Geyer, and Paul R. Carney. Impact of Vascular Disorders on Sleep. In: Fundamentals of Sleep Technology. Eds.: Nic Butkov and Teofilo Lee-Chiong. Lippincott Williams & Wilkins. Chapter 20, 2nd ed., pages 110-134, 2012.


6. Monica M. Henderson, Jennifer Parr-Christmas, James D. Geyer, and Paul R. Carney. Impact of Degenerative Disorders on Sleep. In: Fundamentals of Sleep Technology. Eds: Nic Butkov and Teofilo Lee-Chiong. Lippincott Williams & Wilkins. Chapter 21, 2nd ed., pages 148-172, 2012.

7. Carney PR, Talathi SS, Geyer JD. Pediatric Sleep Issues. Chapter 21, pages 210-239, In: Sleep Medicine Updates, Ed. Octavian Ioachimescu, 1st edition, Bentham Publishing, E-Book, 2012

8. James D. Geyer, Kenneth L. Lichstein, Megan E. Ruiter, L. Charles Ward, Paul R. Carney, Stephanie C. Dillard. Sleep Education for Paradoxical Insomnia, Behavioral Sleep Medicine, 9:4, pages 266-272, 2011.

9. Jennifer Parr-Christmas, Monica M. Henderson, James D. Geyer, and Paul R. Carney. Impact of Vascular Disorders on Sleep. Fundamentals of Sleep Technology, 2nd edition, Chapter 20, pages 215-19, 2011.

10. Monica M. Henderson, Jennifer Parr-Christmas, James D. Geyer, and Paul R. Carney. Impact of Degenerative Disorders on Sleep. Fundamentals of Sleep Technology, 2nd edition, Chapter 21, pages 220-27, 2011.

11. Geyer JD, Carney PR, Dillard SC, Tsikhlakis JC. Sleep and Vascular Disorders. In: Stroke: A Practical Approach. Edited by James D. Geyer and Camilo R. Gomez, Wolters Kluwer, Lippincott Williams & Wilkins, Phil, pages 100-106, 2009.

12. Carney PR, Geyer JD, Saxonhouse MA, Gomez CR, Malaty I. Pediatric Stroke. In: Stroke: A Practical Approach. Edited by James D. Geyer and Camilo R. Gomez, Wolters Kluwer, Lippincott Williams & Wilkins, Phil, pages 130-140, 2009.

13. Geyer JD, Carney PR, Lichstein K, Dillard SC, Henderson MM. Sleep and Acute Stroke. In: Stroke: A Practical Approach. Edited by James D. Geyer and Camilo R. Gomez, Wolters Kluwer, Lippincott Williams & Wilkins, Phil, pages 301-307, 2009 .

14. Carney PR, Fisher N, Ditto, WL. Geyer JD. Quantitative Sleep Monitoring. In: Quantitative EEG Analysis Methods and the Application. Editors: Shanbao Tong and Nitish V. Thakor, Artech House, Inc., of Norwood, MA, USA, pages 257-288, 2009.

15. Carney PR. Alterations of Consciousness New Patient. In: Child Neurology Telephone Encounter Guides. Eds. Sprague-McRae, J, Rosenblum R, Morrison L. Association of Child Neurology Nurses, 1st ed, pages 23-62, 2009.

16. Geyer JD, Carney PR, Parr J., Dillard SC. Sleep Disorders and Degenerative Neurologic Disorders. In: Fundamentals of Sleep Technology. Eds: Nic Butkov and Teofilo Lee-Chiong. Lippincott Williams & Wilkins. 1st ed, 2007; 206-214.

17. Monica M. Henderson, Jennifer Parr-Christmas, James D. Geyer, and Paul R. Carney. Sleep and Degenerative Neurologic Disorders. Textbook of Polysomnography. Association of Polysomnographic Technologists. Eds. L. Chiong, L. Shigley. Lippincott, Williams & Wilkins. pages 144-178, 2006.

18. Jennifer Parr-Christmas, Monica M. Henderson, James D. Geyer, and Paul R. Carney. Sleep and Vascular Disease. Textbook of Polysomnography. Association of Polysomnographic Technologists. Eds. L. Chiong, L. Shigley. Lippincott, Williams & Wilkins, pages 205-238, 2006.

In Press Submitted Chapters:

Geyer JD and Carney PR. Breckon Angie, Chapter 45, Artifacts, Review of Sleep Medicine 4e, 17 pages, in press 2017.

Monographs:

1. Carney PR and Jiang Huabei. Noninvasive Functional and Cellular Imaging of Epilepsy. In: The Textbook of Neurophotonics in Brain Mapping. Eds: Babak Kateb. CRC Press, Taylor Francis Group pubs, pages 111-127, 2014.


2. Carney PR. Applications of nanotechnology in epilepsy. In: Nanoneurosurgery and Nanoneuroscience. Eds: Babak Kateb and John D. Heiss. CRC Press, Taylor Francis Group pubs, pages 51-69, 2013.

3. Carney PR, Talathi SS, Hwang DU, Ditto W. Circadian Regulation of Neural Excitability in Temporal Lobe Epilepsy. Chapter 19, Ed: Osorio I. Int. Seizure Prediction Conf. Proceedings, pages 64-79, 2012.

4. Carney PR, Talathi SS, Hwang DU, Ditto W. Circadian Regulation of Neural Excitability in Temporal Lobe Epilepsy. Chapter 19, Ed: Osorio I. Int. Seizure Prediction Conf. Proceedings, pages 178-194, 2012.

5. Philip Barish, Svetlana Kantorovich, Paul R. Carney, William Ogle. Decoding Neural Circuitry with Optogenetics: Applications for Epilepsy. In: From the Hallowed Halls of Herpes virology – A Tribute to Bernard Roizman. Eds: John A. Blaho and Joel D. Baines, Editors World Scientific Publishing / Imperial College Press, pages 47-61, 2010.

6. Fisher N, Talathi S, Cadotte A, Meyers, S, Carney PR. Epilepsy Detection and Monitoring, In: Quantitative EEG Analysis Methods and the Application. Eds: Shanbao Tong and Nitish V. Thakor, Artech House, Inc., of Norwood, MA, USA, pages 141-167, 2009.

7. Carney PR. Korhman MH. Relation between epilepsy and sleep during infancy and childhood. In: Sleep and Epilepsy: The Clinical Spectrum. Eds. Malow BM, Bazil C, Sammaritano M. Pub. Elsevier Science, pages 359-372, 2002.

8. Poston MR, * Fredieu J, *, Carney P, * Silver J. The role of glia and neural crest cells in creating axon pathways and boundaries in the vertebrate central and peripheral nervous systems. In: The Making of the Nervous System. Oxford University Press, Parnavelas JG, Stern CD, Stirling RV, Eds, pages 282-313, 1986.

Peer-reviewed manuscripts:

*Indicates student co-author; + indicates postdoctoral fellow co-author

1. Anderson CL, * DeMarse TB, Febo M, Johnson CR, Earnest V,* Carney PR. Cannabidiol for the treatment of drug resistant epilepsy in children: Current state of research. 2017, 28 pages, J. Ped Neuro, in press

2. Huang L, Ni X, Ditto WL, Spano M, Carney PR, Lai YC. Detecting and characterizing high-frequency oscillations in epilepsy: a case study of big data analysis. R Soc Open Sci. 2017 Jan 18;4(1):160741.

3. Middlebrooks EH, Quisling RG, King MA, Carney PR, Roper S, Colon-Perez LM,+ Mareci TH. The hippocampus: detailed assessment of normative two-dimensional measurements, signal intensity, and subfield conspicuity on routine 3T T2-weighted sequences. Surg Radiol Anat. 2017 Mar 12.

4. Natarajan G,* Leibowitz JA,* Zhou J, Zhao Y, King MA, Ormerod BK, Carney PR. Adeno-associated viral vector-mediated preprosomatostatin expression suppresses induced seizures in kindled rats. Epilepsy Res. 2017 Jan 7;130:81-92.

5. Ying-Cheng L, Lanzhou LN, Ditto W, Spano M, Carney P, Lai YC. Detecting and characterizing high frequency oscillations in epilepsy. R. Soc. open sci. 2017:4:160741.

6. Geyer JD, Geyer EE, Fetterman Z, Carney PR. Epilepsy and restless legs syndrome. Epilepsy and Behavior. 2017: 68: 41-44.

7. Glushakov AV, Glushakova OY, Doré S, Carney PR, Hayes RL. Animal Models of Posttraumatic Seizures and Epilepsy. Methods Mol Biol. 2016;1462:481-519.

8. Kuhn T, * Gullett JM, * Nguyen P, * Boutzoukas AE, * Ford A, + Colon-Perez L, + Triplett W, Carney PR, Mareci TH, Price CC, Bauer RM. Test-retest reliability of high angular resolution diffusion imaging acquisition within medial temporal lobe connections assessed via tract based

https://www.ncbi.nlm.nih.gov/pubmed/27604735

https://www.ncbi.nlm.nih.gov/pubmed/27604735


spatial statistics, probabilistic tractography and a novel graph theory metric. Brain Imaging Behav. 2016 Jun;10(2):533-47.

9. Dai W, * Astary GW, + Kasinadhuni AK, * Carney PR, Mareci TH, Sarntinoranont M. Voxelized model of brain infusion that accounts for small feature fissures: Comparison with MR tracer studies. J Biomech Eng. 2016 May 1: 138 (5).

10. Zhang T, Zhou J, Carney PR, Jiang H. Towards real-time detection of seizures in awake rats with GPU-accelerated diffuse optical tomography. J Neurosci Methods. 2015: 240:28-36

11. Tolaymat A, Nayak A, Geyer JD, Geyer JD, and Carney PR. Diagnosis and Management of Childhood Epilepsy. Current Problems in Pediatric and Adolescent Health Care.2015; 1-17.

12. Yang H, * Zhang T, * Zhou J, + Carney PR, Jiang H. In vivo imaging of epileptic foci in rats using a miniature probe integrating diffuse optical tomography and electroencephalographic source localization. Epilepsia. 2015 Jan; 56(1): 94-100.

13. Tang J, Zhou, J, Huang H, Zhang T, Carney PR, Jiang H. Non-invasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats. J Cereb Blood Flow Metab. 2015 Aug;35(8):1224-32.

14. Colon-Perez LM, + Spindler C, * Goicochea S, * Triplett W, Parekh M, + Montie E, Carney PR, Price C, Mareci TM. Dimensionless, scale invariant, edge weight metric for the study of complex structural networks. PLoS One. 2015 Jul 14; 10(7): e0131493.

15. Colon-Perez LM, + King M, Parekh M, + Boutzoukas A, * Carmona E, * Couret M, * Klassen R, * Mareci T, Carney PR. High-field magnetic resonance imaging of the human temporal lobe. Neuroimage Clin. 2015 Aug 1; 9:58-68.

16. Zhang T, * Zhou J, + Jiang R, * Yang H, + Huabei Jiang H, Carney PR. Pre-seizure state identified by diffuse optical tomography. Sci. Rep. 2014 Jan 21; 4:3798

17. Shivakesavan-Giridharan S*, Stefenscau RA+, Khargonekar PP, Carney PR, Talathi SS. Genesis of interictal spikes in the CA1: a computational investigation. Frontiers in Neural Circuits, 2014 Jan 27; 8:2.

18. Casanova F, * Carney PR, Sarntinoranont M. Effect of needle insertion speed on tissue injury, stress, and backflow distribution for convection-enhanced delivery in the rat brain. PLoS One, 2014 Apr 28; 9(4): e 94919

19. DeMarse TB, Carney PR. Augmentation of cognitive function in epilepsy. Front Syst Neurosci. 2014 Aug 14; 8: 147.

20. Casanova F, Carney PR, Sarntinoranont M. In vivo evaluation of needle force and friction stress during insertion at varying insertion speed into the brain. J Neurosci Methods. 2014 Nov 30; 237: 79-89.

21. Stanley DA, Talathi SS, Carney PR. Chronotherapy in the treatment of epilepsy. Chrono Physiology and Therapy. Dove press. 109-123; 26 November 2014.

22. Astary GW,* Peprah MK+, Fisher CR, * Stewart RL, Carney PR, Sarntinoranont M, Meisel MW, Manuel MV, Mareci TH. MR Measurement of Alloy Magnetic Susceptibility: Towards Developing Tissue-Susceptibility Matched Metals. Magn Reson. 2013 May 13; 233C: 49-55

23. Carney PR. Special Issue on Epilepsy. Exp. Neurol. 2013 Jun; 244C: 1-3.

24. Stanley DA, * Talathi SS, Parekh MB, Cordiner DJ, * Zhou J+, Mareci TH, Ditto WL, Carney PR. Phase shift in hippocampal circadian rhythm during the latent period of epileptic rats. J Neurophysiology. 2013 Sep; 110(5): 1070-86.

25. Kantorovich S+, Astary GW+, King MA, Mareci TH, Sarntinoranont M, Carney PR. Influence of acute brain injury status epilepticus on convection-enhanced delivery in the rat hippocampus. PLoS One, 2013 Nov 8; 8(11): e80606.


26. Boykin ER*, Khargonekar PP, Carney PR, Ogle WO, Talathi SS. Detecting effective connectivity in networks of coupled neuronal oscillators. J. Comput. Neurosci. 2012 Jun; 32(3): 521-38.

27. Zafar R*, King MA, Carney PR. Adeno associated viral vector-mediated expression of somatostatin in rat hippocampus suppresses seizure development. Neurosci. Lett. 2012: 509: 87-91.

28. Kim JH*, Astary GW*, Kantorovich S*, Mareci TH, Carney PR, Sarntinoranont M. Voxelized Computational Model for Convection Enhanced Delivery in the Rat Ventral Hippocampus: Comparison with In Vivo MR Experimental Studies. Ann Biomed. Eng. 2012; 40: 2043-58.

29. Kim JH*, Astary GW*, Nobrega TL*, Kantorovich S*, Carney PR, Mareci TH, Sarntinoranont M. Dynamic contrast-enhanced MRI of Gd-albumin delivery to the rat hippocampus in vivo by convection-enhanced delivery. J Neurosci. Methods. 2012 Jun 8; 209(1): 62-73.

30. Casanova F, * Carney PR, Sarntinoranont M. Influence of needle insertion speed on backflow for convection-enhanced delivery. J Biomech Eng. 2012 Apr; 134(4):041006.

31. Wang B*, Xiang L, Jiang MS*, Yang J*, Zhang Q*, Carney PR, Jiang H. Photoacoustic tomography system for noninvasive real-time three-dimensional imaging of epilepsy. Biomed Opt Express. 2012 Jun 1; 3(6): 1427-32.

32. Ji L*, Zhou J, Zafar R*, Kantorovich S*, Jiang R*, Carney PR, Jiang H. Cortical neurovascular coupling driven by stimulation of channelrhodopsin-2. PLoS One. 2012; 7(9): e46607.

33. Xiang L* Ji L, * Zhang T, * Wang B, * Yang J, * Zhang Q, * Jiang MS, * Zhou J, + Carney PR, Jiang H. Non-invasive real-time tomographic imaging of epileptic foci and networks. NeuroImage, 2012 Nov 2; 66C: 240-248.

34. Talathi SS, Carney PR, and Khargonekar PP. Control of neural synchrony using channel rhodopsin 2: a computational study. J Comput. Neurosci. 2011 Aug; 31(1): 87-103. Epub 2010 Dec 21

35. Carney PR, Myers, S* Geyer JD. Seizure prediction: methods. Epilepsy & Behavior. 2011 Dec; 22 Suppl 1: S94-S101.

36. Geyer JD, Lichstein KL, Ruiter ME, Ward LC, Carney PR, Dillard SC. Sleep education for paradoxical insomnia. Behav. Sleep Med. 2011 Sep 30; 9(4): 266-72.

37. Talathi SS, Hwang D+, Carney PR., Ditto W. Synchrony with shunting inhibition in a feed forward inhibitory network. J Comput. Neurosci. 2010 Apr; 28(2): 305-21.

38. Astary GW, * Kantorovich S, * Carney PR, and Mareci TH, Sarntinoranont M. Regional convection enhanced delivery of gadolinium labeled albumin into the rat hippocampus in vivo. J Neurosci. Methods. 2010 Mar 15; 187 (1): 129-37.

39. Cadotte AJ+, DeMarse TB, Mareci TH, Parekh M, * Talathi SS, Hwang DU, * Ditto WL, Ding M, Carney PR. Granger causality relationships between local field potentials in an animal model of temporal lobe epilepsy. J Neurosci. Methods. 2010 May 30; 189(1): 121-9.

40. Fisher N, * Talathi SS, Carney PR, Ditto WL. Effects on homeostatic spike rate. Biol. Cybern. 2010 May: 102 (5): 427-40.

41. Nandan M, * Talathi SS, Myers S, * Ditto WL, Khargonekar PP, Carney PR. Support vector machine algorithms for seizure detection in an animal model of chronic epilepsy. J Neural Eng. 2010 Jun; 7(3): 036001.

42. Parekh MB*, Carney PR, Sepulveda H*, Norman W+, King M, Mareci TH. Early MR diffusion and relaxation changes in the parahippocampal gyrus precede the onset of spontaneous seizures in an animal model of chronic limbic epilepsy. Exp. Neurol. 2010 Jul; 224(1): 258-70.


43. Geyer JD, Carney PR, Dillard SC, Davis L, Ward LC. Antidepressant medications, neuroleptics and prominent eye movements during NREM Sleep. J Clin. Neurophysiology. 2009 Feb; 26(1): 39-44.

44. Nair SP, * Shiau DS, + Principe JC, Iasemidis LD, Pardalos PM, Norman WM, + Kelly KM, Sackellares JC, Carney PR. An investigation of EEG dynamics in an animal model of temporal lobe epilepsy using the maximum Lyapunov exponent. Exp. Neurol. 2009 Mar; 216(1): 115-21.

45. Talathi SS+, Hwang DU+, Ditto WL, Mareci T, Sepulveda H*, Carney PR. Circadian control of neural excitability in an animal model of temporal lobe epilepsy. Neurosci. Lett. 2009 May 15; 455(2): 145-9.

46. Komalapriya C*, Romano MC*, Thiel M, Schwarz U, Kurths J, Simonotto J, Furman M, Ditto WL, Carney PR. Predictability of spontaneous limbic seizures using recurrence measures. Int. J. Bifurcation and Chaos. 2009:19(2): 605-617.

47. Cadotte A+, Mareci T, DeMarse T, Parekh M*, Rajagovindan R*, Ditto W, Talathi S, Hwang DU, Carney PR. Temporal lobe epilepsy: anatomical and effective connectivity. IEEE Trans Neural Syst. Retail. Eng. 2009 Jun; 17 (3): 214-23.

48. Gunduz A*, Sanchez JC+, Carney PR, Principe JC. Mapping broadband electrocorticographic motor control features to two-dimensional hand trajectories in humans’ motor control features. Neural Netw. 2009 Nov; 22(9): 1257-70.

49. Talathi SS, Hwang DU, Miliotis A*, Carney PR, Ditto WL. Predicting synchrony in heterogeneous pulse coupled oscillators. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Aug; 80:021908.

50. Saxonhouse M, Tarquinio D*, Carney P, Bennett J, Smith A, Hunger S, Geyer J. Low molecular weight heparin use in a case of noncardiogenic multifocal perinatal thromboembolic stroke. Adv. Hematol. 2009:153643.

51. Kumar R*, Vemuri BC, Wang F*, Syeda-Mahmood T*, Carney PR, Mareci TH. Multi-fiber reconstruction from DW-MRI using a continuous mixture of hyperspherical von Mises-Fisher distributions. Inf. Process Med. Imaging. 2009: 21:139-50.

52. Sanchez JC+, Gunduz A*, Carney PR, Principe JC. Extraction and localization of mesoscopic motor control signals for human ECoG neuroprosthetics. J Neurosci Methods. 2008:167 (1): 63-81.

53. Wang Q*, Liang X*, Liu Z, Zhang Q*, Carney PR, Jiang H. Visualizing localized dynamic changes during epileptic seizure onset in vivo with diffuse optical tomography. Med Phys. 2008; 1: 216-224.

54. Zhang Q*, Liu Z, Carney PR, Yuan Z*, Chen X+. Roper SN, Jiang H. Noninvasive imaging of epileptic seizures in vivo using photoacoustic tomography. Phys. Med. Biol. 2008 53:1921-1931.

55. Talathi SS+, Hwang DU+, Ditto WL, Spano M, Myers SM*, Winters J*, Simonotto J*, Carney PR. Non-parametric early seizure detection in an animal model of temporal lobe epilepsy. J. Neural Eng. 2008 Mar; 5 (1): 85-98.

56. Carney PR, Cadotte A+, DeMarse TB, Vemuri B, Mareci T, Ditto W. Effective and anatomical connectivity in a rat model of spontaneous limbic seizures. In: Seizure Prediction in Epilepsy: From Basic Mechanisms to Clinical Application. Wiley Vch Verlag GmbH & Co. KGaAA, Schelter B, Timmer J, Schultze-Bonhage A, Eds, 45-59, 2008.

57. Stacpoole PW, Gilbert LR, Neiberger RE, Carney PR, Valenstein E, Theriaque DW, Shuster JJ. Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate. Pediatrics. 2008 May: 121(5): e1223-8.

58. Chaovalitwongse W*, Pardalos PM, Iasemidis LD, Suharitdamrong DS*, Dance L+, Prokopyev OA*, Boginski V*L, Carney PR, Sackellares JC. Data mining in EEG: applications to epileptic


brain disorders. In: Data Mining in Biomedicine. Series: Springer Optimization and its Applications. Pardalos, Panos M. Boginski, Vladimir L; Vazacopoulos, Alkis (Eds.), 7:459: 2007.

59. Shiau DS+, Iasemidis LD, Yang MCK, Pardalos PM, Carney PR, Dance L+, Chaovalitwongse W*, Sackellares JC. Automated seizure prediction algorithm and its statistical assessment: a report from ten patients. In: Data Mining in Biomedicine. Series: Springer Optimization and its Applications, Pardalos, Panos M. Boginski, Vladimir L; Vazacopoulos, Alkis (Eds.), 7:517:2007.

60. Nair SP*, Shiau DS+, Iasemidis LD, Norman WM+, Pardalos PM, Sackellares JC, Carney PR. Seizure predictability in an experimental model of epilepsy. In: Data Mining in Biomedicine. Series: Springer Optimization and its Applications, Pardalos, Panos M. Boginski, Vladimir L; Vazacopoulos, Alkis (Eds.), 7:535:2007.

61. Prokopyev OA*, Boginski VL*, Chaovalitwongse W*, Pardalos PM, Sackellares JC, Carney PR. Network-based techniques in EEG data analysis and epileptic modeling. In: Data Mining in Biomedicine. Series: Springer Optimization and its Applications, Pardalos, Panos M. Boginski, Vladimir L; Vazacopoulos, Alkis (Eds.), 7:559:2007.

62. Hwang Dong-UK+, Talathi S+, Carney PR, Ditto W, Myers S*, Norman W, Simonotto J*. High frequency oscillations in the limbic rat model of temporal lobe epilepsy. Computational Neuroscience. 2007.

63. Martynyuk AE, Ucar DA, Yang DD, Norman WM+, Carney PR, Dennis DM, Laipis PJ. Epilepsy in phenylketonuria: A complex dependence on serum phenylalanine levels. Epilepsia. 2007 Jun; 48(6): 1143-50.

64. Jian B*, Vemuri BC, Ozarslan E+, Carney P, Mareci T. A novel tensor distribution model for the diffusion weighted MR signal. NeuroImage. 2007 Aug 1; 37 (1): 164-76.

65. Ramirez-Manzanares A*, Rivera M*, Vemuri BC, Carney P, Mareci T. Diffusion basis functions decomposition for estimating white matter intra-voxel fiber geometry. IEEE Transactions on Medical Imaging. 2007: 26:1091-1102.

66. Talathi SS+, Hwang DU+, Ditto W, Carney PR. Early seizure detection in an animal model of temporal lobe epilepsy, Data Mining, Systems Analysis and Optimization in Biomedicine, AIP Conf Proc. 2007; 953:292-307.

67. Nair S*, Sackellares JC, Shiau DS+, Norman W+, Dance L, Pardalos P, Principe JP, Carney PR. Effects of acute hippocampal stimulation on EEG dynamics. IEEE Med Biol. 2006; 1: 4382-6

68. Mishra M*, Jones B*, Simonotto JD*, Furman MD+, Norman W+, Liu Z, DeMarse TB, Carney PR, Ditto WL. Pre-ictal correlation and entropy analysis of microwire data from an animal model of limbic epilepsy. IEEE Eng. Med Biol. 2006; 1: 1605-7.

69. Simonotto JD*, Myers SM*, Furman MD+, Norman WM+, Liu Z, DeMarse TB, Ditto WL, Carney PR. Coherence analyses over the latent period of epileptogenesis reveal that high-frequency communication is increased across hemispheres in an animal model of limbic epilepsy. IEEE Eng. Med Biol. 2006; 1:1154.

70. Nelson R*, Myers S*, Simonotto J*, Furman M+, Spano M, Norman W+, Liu Z, DeMarse T, Ditto W, Carney PR. Detection of high frequency oscillations with Teager energy in an animal model of limbic epilepsy. IEEE Eng. Med Biol Soc. 2006; 1: 2578-80.

71. Sanchez JC, Carney PR, Principe JC. Analysis of amplitude modulated control features for ECoG neuroprosthetics. IEEE Eng. Med Biol. 2006;1: 5468-71.

72. Qizhi Z*, Liu Z, Carney PR, Jiang H. Imaging epilepsy using finite element-based photoacoustic tomography: initial in vivo results. Biomedical Optics Tech Dig ME18: 2006.

73. Geyer JD, Carney PR, Gilliam F. Focal epileptiform spikes in conjunction with k-complexes. J Clin Neurophysiology. 2006 Oct; 23(5): 437-440.


74. Sanchez JC+, Mareci T, Norman W+, Principe J, Ditto W, Carney PR. Evolving into epilepsy: Multiscale electrophysiological analysis and imaging in an animal model. Exp Neurol. 2006 Mar; 198(1): 31-47.

75. Nair SP*, Shiau DS+, Iasemidis LD, Norman WM+, Pardalos PM, Sackellares CS, Carney PR. Seizure predictability in an experimental model of epilepsy. Proc Quant Neurosci Conf. 2006; 213-220.

76. Stickler DE, Valenstein E, Neiberger RE, Perkins LA, Carney PR, Shuster JJ, Theriaque DW, Stacpoole PW. Peripheral neuropathy in genetic mitochondrial diseases. Pediatric Neurol. 2006 Feb; 34(2): 127-31.

77. Miller J, Carney P. Central hypothyroidism with oxcarbazepine therapy. Pediatric Neurol. 2006 Mar; 34(3): 242-4.

78. Stacpoole PW, Kerr DS, Barnes C, Bunch ST, Carney PR, Fennell E, Felitsyn NM, Gilmore R, Greer M, Henderson G, Hutson AD, Neiberger R, O'Brien R, Perkins LA, Quisling R, Shroads AL, Shuster JJ, Silverstein JH, Theriaque DW, Valenstein E. A controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children. Pediatrics. 2006 May: 117(5): 1519-1531.

79. Sanchez JC+, Alba N*, Nishida T, Batich C, Carney PR. Structural modifications in chronic microwire electrodes for cortical neuroprosthetics. IEEE TNSRE. 2006: 14(2): 217-221.

80. Chaovalitwongse WA*, Iasemidis LD, Pardalos PM, Carney PR, Shiau DS, Sackellares JC. Reply to comments on Performance of a seizure warning algorithm based on the dynamics of intracranial EEG by Mormann, F., Elger, C.E., and Lehnertz, K. Epilepsy Res. 2006 Nov; 72(1): 85-7.

81. Pardalos PM, Boginski VL,+ Prokopyev OA,* Suharitdamrong W, Carney PR, Chaovalitwongse W,* Vazacopoulos A. Optimization Techniques in Medicine. In: Eds. Audet C, Hansen P, Savard G. Essays and Surveys in Global Optimization. Springer, 2005; 151-173

82. Sanchez JC, + Principe JC, Carney PR. Is neuron discrimination preprocessing necessary for linear and nonlinear brain machine interface models? 11th Inter Conf on Human-Computer Interaction. 2005; 1100-15

83. Iasemidis LD, Shiau DS, + Pardalos PM, Chaovalitwongse W, * Narayanan K, Prasad A, * Tsakalis K, + Carney PR, Sackellares JC. Long-term prospective on-line real-time seizure prediction. Clin Neurophysiology. 2005 Mar: 116(3): 532-44.

84. Chaovalitwongse W* Iasemidis LD, Pardalos PM, Shiau DS, + Sackellares JC, Carney PR. Performance of a seizure warning algorithm based on the dynamics of intracranial EEG. Epilepsy Res. 2005 May: 64(3): 93-113.

85. Dharnidharka VR and Carney PR. Isolated idiopathic hypomagnesaemia presenting as aphasia and seizures. Pediatric Neurol. 2005 Jul; 33(1): 61-5.

86. Shiau DS+, Nair SP*, Iasemidis LD, Norman W+, Principe JC, Pardalos PM, Suharitdamrong W*, Cho J, * Sackellares JC, Carney PR. Seizure warning and dynamic response to electrical stimulation in a rodent model of chronic limbic epilepsy. IEEE Engineering in Medicine and Biology. 2005: 95-100.

87. Iasemidis LD, Shiau DS+, Pardalos PM, Chaovalitwongse W*, Narayanan K*, Prasad A*, Tsakalis K, + Sackellares JC, Carney PR. Long-term prospective on-line real-time seizure prediction. Clinical Neurophysiology. 2005; 116 (3): 532-544.

88. Chaovalitwongse W*, Pardalos PM, Iasemidis LD, Carney PR, Shiau DS, + Suharitdamrong W*, Sackellares JC. A robust method for studying the dynamics of the intracranial EEG: Application to epilepsy. Epilepsy Res. 2005; 64: 93-113.


89. Shiau DS+, Nair SP*, Iasemidis LD, Carney PR, Norman WM+, Principe JC, Pardalos PM, Suharitdamrong W*, Cho J*, Sackellares JC. Seizure warning and dynamic response to electrical stimulation in a rodent model of chronic limbic epilepsy. Proceedings of 3rd European Medical and Biological Conference, Prague, Czech Republic: Vol. 11, 2005.

90. Becker DA*, Fennell EB, Carney PR. Daytime behavior and sleep disturbance in childhood epilepsy. Epilepsy Behav. 2004: 5: 708-15.

91. Sackellares JC, Iasemidis LD, Shiau LD+, Pardalos PM, Carney PR. Spatiotemporal transitions in temporal lobe epilepsy. In: Quantitative Neuroscience: Models, Algorithms, Diagnostics, and Therapeutic Applications. Kluver Academic Publishers 2004; 223-38.

92. Shiau DS+, Chaovalitwongse W*, Iasemidis LD, Pardalos PM, Carney PR, Sackellares JC. Nonlinear dynamical and statistical approaches to investigate dynamical transitions before epileptic seizures. In: Quantitative Neuroscience: Models, Algorithms, Diagnostics, and Therapeutic Applications. Kluver Academic Publishers 2004; 239-50.

93. Yang MCK, Shiau DS+, Sackellares JC, Carney PR. Testing whether a prediction scheme is better than guess. Pardalos PM, Sackellares JC, Carney PR., and Iasemidis LD (Eds). In: Quantitative Neuroscience: Models, Algorithms, Diagnostics, and Therapeutic Applications. Kluver Academic Publishers 2004; 251-259.

94. Carney PR, Shiau DS+, Pardalos PM, Iasemidis LD, Chaovalitwongse W*, Sackellares JC. Nonlinear neurodynamical features in an animal model of generalized epilepsy. In: Quantitative Neuroscience: Models, Algorithms, Diagnostics, and Therapeutic Applications. Kluver Academic Publishers, 2004, 37-52.

95. Pardalos PM, Chaovalitwongse W, * Iasemidis LD, Sackellares JC, Shiau DS, + Carney PR, Prokopyev OA*, Yatsenko VA. Seizure warning algorithm based on optimization and nonlinear dynamics. Math. Program Ser B. 2004:35-50.

96. Iasemidis LD, Pardalos PM, Shiau DS+, Chaowolitwongse W*, Narayanan K, Kumar S, Carney PR, Sackellares JC, Prediction of human epileptic seizures based on optimization and phase changes of brain electrical activity. Optimization Methods and Software. 2003: 18(1): 81-104.

97. Yatsenko V, Carney P, Pardalos P, Sackellares JC, Shiau DS+. Control of chaotic systems: a practical application to epilepsy, Proc. of Second International Conference on Control Problems, Moscow, Institute of Control Problems. 2003; 205-218.

98. Yatsenko V, Sackellares C, Pardalos P, Carney P. Geometric models, fiber bundles and biomedical applications. Fifth International Conference: Symmetry in Nonlinear Mathematical Physics, Institute of Mathematics. Kiev, 2003; 195-217.

99. Iasemidis LD, Shiau DS+, Chaovalitwongse W*, Sackellares JC, Pardalos PM, Principe JC, Carney PR, Prasad A, Veeramani B, Tsakalis K. Adaptive epileptic seizure prediction system. IEEE Trans Biomed Eng. 2003 May: 50(5): 616-27.

100. Becker DA, * Fennell, EB, Carney PR. Sleep disturbance in children with epilepsy. Epilepsy Behav. 2003: 4(6): 651-8.

101. Stickler DE, * Carney PR, Valenstein ER. Juvenile-onset Leigh syndrome with an acute polyneuropathy at presentation. Child Neurol. 2003; 18(8): 574-6.

102. Glueckauf RL, Fritz SP, * Ecklund-Johnson EP, * Liss HJ, * Dages P, * Carney P. Videoconferencing based family counseling for rural teenagers with epilepsy: Phase 1 findings. Rehab Psychol. 2002; 47(1): 49-72.

103. Kramer MJ, * LaRussa P, Tsai W, Carney P, Leber S, Gahagan S, Steinberg S, Blackwood A. Disseminated vaccine strain varicella as the acquired immunodeficiency syndrome-defining illness in a previously undiagnosed child. Pediatrics. 2001; 108(2): e39-46.


104. Carney PR. Rasmussen's syndrome: Intractable epilepsy and progressive neurological deterioration from a unilateral central nervous system disease. CNS Spectrums. 2001: 6(5): 398-416.

105. MacLennan AJ, Carney PR, Zhu WJ, Chaves AH, Garcia J, Grimes JR, Anderson KJ, Roper SN, Lee N. An essential role for the H218/AGR16/Edg-5/LP (B2) sphingosine 1-phosphate receptor in neuronal excitability. Eur J Neurosci. 2001: 14(2): 203-9.

106. Okun MS, * Jummani RR, * Carney PR. Antiphospholipid-associated recurrent chorea and ballism in a child with cerebral palsy. Pediatric Neurol. 2000; 23(1): 62-3.

107. Tran TX, * Day JA, * Eskin TA, Carney PR, Maria BL. Rasmussen's syndrome: Etiology, clinical features, and treatment options. CNS Drugs. 2000: 14:343-354.

108. Kohrman MH, Carney PR. Sleep-related disorders in neurologic disease during childhood. Pediatric. Neurol. 2000; 23 (2): 107-13.

109. Carney PR, Couve E. Cell polarity changes and migration during early development of the avian peripheral auditory system. Anat Rec.1989; 215:156-164.

110. Carney PR, * Silver J. Studies on cell migration and axon guidance in the developing distal auditory system of the mouse. J Comp Neur.1983; 225:359-369.

In Press/Submitted:

1. Dai X, Zhang T, Yang H, Tang J, Carney PR, Jiang H. Fast non-invasive functional diffuse optical tomography for brain imaging in epilepsy studies. 2017, 38 pages, Epilepsia, submitted

2. Liu X, Carney PR, Bussing R, Segal R, Cottler LB, Winterstein AG. Trend of anticonvulsant use in Medicaid children with epilepsy from 29 US states, 1999-2010. 2017, 39 pages, Epilepsia., submitted

3. Anderson C, Evans VF, DeMarse TB, Ormerod BK, Febo M, Johnson CR, Carney PR. Efficacy and safety of cannabidiol as a treatment for intractable generalized epilepsy in children: an open-label intervention trial. 2917, 28 pages, Lancet, submitted

4. Xi L, Jin T, Zhou J, Carney P, Jiang H. Hybrid photoacoustic and electrophysiological recording of neurovascular communication in freely-moving rats. 2017, 29 pages, Neuroimage, submitted

Abstracts:

1. Jiang H and Carney PR. Non-Invasive Wearable Photoacoustic Tomography for Imaging Hemodynamics in Freely Moving Rats. 1570095989, OECC 2015 in Shanghai, China.

2. Zhou J, Wang, D Carney P. Acute amygdala seizures suppressed by halorhodopsin activation in vivo. American Epilepsy Society Annual Meeting, 2015, 2.119.

3. Liu X, Carney P, Bussing R. Segal, L. Cottler, Winterstein A. Psychotropic drug utilization in children with epilepsy in 29 US states from 1999 to 2010. American Epilepsy Society Annual Meeting, 2015, 1.265.

4. Fisher C, Astary G, Stewart R, Peprah M, Mareci T, Meisel M, Carney PR, Sarntinoranont M, Manuel M. Brain Matched Magnetic Susceptibility in Metallic Alloys for Use during MR Imaging. 2013 TMS Annual Meeting & Exhibition.

5. Magdoom KN, Delgado F, Mahbub H, Carney PR, Sarntinoranont M. Understanding Transport of Nanoparticle-Drug Construct Following Fast Local Infusion in the Rat Brain: A MRI-based Computational Model. ASME (Boston, Mass), Feb 2013.

6. Sarntinoranont M, Carney PR, Mareci TM. MR-Based Biotransport Models of the Brain and Solid Tumors. Society for Brain Mapping and Therapeutics, Baltimore, May 12-14, 2013.

7. Shivakeshavan RG, Stefanescu RA, Khargonekar PP, Carney PR, Talathi SS. Effects of light stimulation on interictal spikes from ChR2 expressed CA1 pyramidal cells. SPIE BiOS, 2013.


8. Stanley D, Talathi, SS, Carney PR. A local phase shift in hippocampal circadian rhythms during epilepsy. International Conference on Computational Biomedicine. Gainesville, FL Feb 29-March 2, 2012.

9. Geyer JD and Carney PR. The relationship between temporal lobe epilepsy and restless legs syndrome. 2012 AES Annual Meeting.

10. Stefanescu, S, Khargonekar P, Talathi, S, Ratnadura, S, Carney PR. Computational Modeling of Light Activated Ion Channels. CNS 2012 meeting.

11. Astary, GW, Kantorovich S, Munson JW, S. J. Lee, SJ, Carney PR, Sarntinoranont, M, and Mareci. TH. MR. Relaxivity of Gd-DTPA-HSA in Brain Tissue: Towards Quantification of Tissue. Biomedical Engineering Society 2012 Annual Meeting

12. Astary GW, Peprah MK, Fisher C, Carney PR, Sarntinoranont M. Meisel W, Manuel M, Mareci TH. Method for Magnetic Susceptibility Adjustment of Metal Alloys and Characterization with MRI. Biomedical Engineering Society 2012 Annual Meeting

13. Sarntinoranont M, Carney PR, Mareci, TH. Convection-Enhanced Delivery of the Treatment of Epilepsy. First CSF Hydrodynamics Symposium. July 8 & 9, 2011. Zurich, Switzerland.

14. Stanley DA, Talathi SS, Ni X, Huang L, Lai YC, Ditto WL, Carney PR. Circadian rhythms of gamma oscillations following status epilepticus: Implications for cognition. American Epilepsy Society, 2011

15. Ji J, Jiang H, Carney PR. Optogenetics: Novel Methods and Innovative Uses. Nanosymposium, Society for Neuroscience Annual Meeting, Wash D.C. 2011

16. Stanley DA, Carney PR, Parekh M, Mareci, TH, Talathi, SS, Ditto WL. Phase shift in hippocampal circadian rhythm during the latent period of epileptic rats. P-76. Organization for Computational Neuroscience Annual Meeting, July 23-28, 2011 Stockholm, Sweden.

17. Boykin ER, Ogle, WO, Carney PR, Khargonekar, PP, Talathi SS. The applicability of effective connectivity measures to time series of neuronal oscillators. P-324. Organization for Computational Neuroscience Annual Meeting, July 23-28, 2011 Stockholm, Sweden.

18. Ratnadura SR, Khargonekar PP, Carney PR, Talathi SS. Model parameter estimation for Channelrhodopsin-2 light gated ion channels. P-325. Organization for Computational Neuroscience Annual Meeting, July 23-28, 2011 Stockholm, Sweden.

19. Stanley DA, Parekh MB, Carney PR., Ditto WL, Mareci TR, Talathi SS. Fimbria loss and its effect on circadian rhythms in epilepsy. Society for Neuroscience Annual Meeting, Baltimore, MD, Nov 2011

20. Astary GW, Kantorovich S, Carney PR, Sarntinoranont M, Mareci TH. Gd-albumin relaxivity in the rat thalamus at 11.1T. ISMRM 2011 Annual Meeting.

21. Cadotte A, Parekh M, Triplett W, Talathi S, Mareci T, Carney PR. Integration of structure, behavior, and function for temporal lobe epilepsy: Evidence for future directions for exploration of ictogenic and epileptogenic transitions. American Clinical Neurophysiology Society, Annual Meeting Feb 2-7, 2010, San Diego, CA, Poster and Abstract B109

22. Ratnadura S, Talathi SS, Carney PR, Khargonekar PP. Synchronization induced by signal propagation delays in inhibitory networks. Nineteenth Annual Computational Neuroscience Meeting July 24-30, 2010, San Antonio, Texas

23. Talathi SS, Ratnadura S, Kantorovich S, Carney PR, Khargonekar PP. Control of neural synchrony with light-activated opsins. Nineteenth Annual Computational Neuroscience Meeting July 24-30, 2010, San Antonio, Texas.

24. Kim JH, Astary G, Kantorovich S, Mareci TH, Carney PR, Sarntinoranont M. Measurement of In Vivo Tracer Distribution during CED in the Rat Brain using DCE-MRI. 37th Annual Mtg and Expo of the Controlled Release Society, Portland, OR, July 10-14, 2010


25. Colon-Perez L, Triplett W, Eisenscheck S, Carney PR, Mareci TH. Fiber tracking the cingulum in the human brain using a novel statistical model of water diffusion measured with MRI. University of Florida College of Medicine Research Day. April 24, 2010

26. Parekh M, Triplett W, Carney PR, Mareci TH. White Matter Reorganization in a Rat Model of Temporal Lobe Epilepsy Observed using Enhanced MRI. University of Florida College of Medicine Research Day. April 24, 2010

27. Astary G, Kantorovich S, Kim, JH, Lee SJ, Nobrega T, Parekh M, Triplett W, Carney PR, Mareci TH, Sarntinoranont M. Convection-Enhanced Delivery for the Potential Delivery of Therapeutic Agents for the Treatment of Epilepsy. University of Florida College of Medicine Research Day April 24, 2010

28. Kantorovich S, Barish, P, Talathi, S, Ratnadura S, Zhou J, Myers S, Ogle, W, Khargonekar PP, Carney PR. Control of hippocampal neural activity using optical stimulation. University of Florida College of Medicine Research Day. April 24, 2010

29. Allen H, Lee K, Jones L, Andrade E, Carney PR, Liu Z, Borum P. Ketogenic Therapy Education Modules for Caregivers and Healthcare Professionals. Experimental Biology 2010 in Anaheim CA

30. Kantorovich S., Astary, G., Parekh M.B., Mareci T.H., Sarntinoranont M., Carney PR. Status epilepticus affects hippocampal structure and infusate distribution profiles. Neuroscience 2010. San Diego CA, November 13-17th, 2010

31. Cadotte A, Myers S, Parekh M, Talathi SS, Mareci T, Carney PR. Slow changes during epileptogenesis in a spontaneously seizing animal model of temporal lobe epilepsy. American Epilepsy Society 64th Annual Meeting Dec 3-7, 2010

32. Talathi SS, Zhao J, Cadotte A, Carney PR. Circadian rhythm of core body temperature in an animal model of chronic epilepsy. American Epilepsy Society 64th Annual Meeting Dec 3-7, 2010

33. Yuan Z, R. Jiang R, Ji L, Zhou J, Carney PR, Jiang H. Combining Granger causality and diffuse optical tomography to investigate the effective connectivity in temporal lobe epilepsy. Poster No. 3.235. American Epilepsy Society 64th Annual Meeting Dec 3-7, 2010

34. Zhang, Q, Hu Z, Yuan B, Zhou J, Carney PR, Jiang H. High temporal resolution photoacoustic imaging for seizure localization and network mapping. Poster No. 3.172 American Epilepsy Society 64th Annual Meeting Dec 3-7, 2010

35. Jiang Q, Ji LZ, J. Zhou J, Carney PR, Jiang H. Noninvasive imaging of epilepsy using fast diffuse optical tomography. Poster No. 3.157. American Epilepsy Society 64th Annual Meeting Dec 3-7, 2010

36. Andrade E, Liu Z, Eisenscheck S, Cibula, SJ, Goldsmith I, Parekh M, Triplett W, Cadotte A, Mareci T, Carney PR. 3T Brian MRI and Ictal Findings of patients with nonlesional partial epilepsy refractory to medical treatment. American Epilepsy Society 64th Annual Meeting Dec 3-7, 2010

37. Cadotte A, Myers S, Parekh M, Talathi S, Mareci, TH, Carney PR. Slow changes in functional connectivity during epileptogenesis in a spontaneously seizing animal model of temporal lobe epilepsy. 1.056 American Epilepsy Society 64th Annual Meeting Dec 3-7, 2010

38. Talathi SS, Carney PR, Khargonekar PP. In-phase neural synchrony through optical stimulation. Poster No. 44.10/H38. 2010 Neuroscience. San Diego, CA: Society for Neuroscience, 2010

39. Twyford P. DeMarse T, Barish P, Ogle W, Carney PR. Spatiotemporally precise optical system for controlling neural activity in vitro. Poster No. 816.1/NNN22. 2010 Neuroscience San Diego, CA: Society for Neuroscience, 2010


40. Kantorovich, S, Astary GW, Parekh M, Mareci TH, Sarntinoranont M, Carney PR. Convection enhanced delivery as a local anticonvulsant delivery method for the treatment of epilepsy. Society for Neuroscience Annual Meeting, Chicago, 2009

41. Zafar R, King MA, Frazier CJ, Carney PR. Adeno-associated viral vector delivered somatostatin as a neuroprotective agent for temporal lobe epilepsy. Society for Neuroscience Annual Meeting, Chicago, 2009

42. Parekh MB, Triplett WT, King MA, Mareci TH, Carney PR. Early damage in the parahippocampal gyrus after status epilepticus as a structural signature for the development of spontaneous seizures-a longitudinal study using enhanced MRI. Society for Neuroscience Annual Meeting, Chicago, 2009.

43. Talathi SS, Hwang DU, Ditto WL, Carney PR. Circadian control of neural excitability in an animal model of temporal lobe epilepsy. 61st Annual Meeting of the American Academy of Neurology, 2009.

44. Talathi SS, Hwang DU, Miliotis A, Carney PR, Ditto WL. Synchrony with Shunting Inhibition. Eighteenth Annual Computational Neuroscience Meeting CNS 2009.

45. Astary GW, Kantorovich S, Parekh MB, Triplett WT, Carney PR, Mareci TH, Sarntinoranont M. Regional convention-enhanced delivery of gadolinium-labeled albumin in the rat hippocampus in vivo. BMES, 2009.

46. Myers S, Talathi S, and Carney PR. Determining the firing rate of interictal population spikes leading to seizures. 2.102, 63rd Annual Meeting of the American Epilepsy Society, Boston, MA, 2009

47. Zhou J, Talathi S, Cadotte A, Liu Z, Holmes G, Carney PR. The effects of hippocampus CA1 single neuron firing properties on interictal spike patterns during onset in a rat model of temporal lobe epilepsy. 3.330, 63rd Annual Meeting of the American Epilepsy Society, Boston, MA, 2009

48. Talathi S, Nandan M, Ditto W, Khargonekar P, Carney PR. Support vector machine algorithms for early seizure detection in an animal model of temporal lobe epilepsy. 3.242, 63rd Annual Meeting of the American Epilepsy Society, Boston, MA, 2009

49. Cadotte A, Talathi S, Zhou J, Myers S, Hwang D, Ditto W, Carney PR. Analysis of hippocampal interdependencies for early seizure detection. 3.067, 63rd Annual Meeting of the American Epilepsy Society, Boston, MA, 2009

50. Sarntinoranont, M., Kim, J.H., Carney PR, Mareci, T.H. Diffusion Tensor Imaging- based Computational Models of Convection-Enhanced Delivery. 6th Annual World Congress of the International Brain Mapping & Intraoperative Surgical Planning Society (IBMISPS), Boston, MA, August 26-29, 2009

51. Astary G.W., Kantorovich S., Parekh M.B., Carney PR, Mareci T.H Sarntinoranont M. Convection Enhanced Delivery of an MR Contrast Agent to the Dorsal and Ventral Hippocampus. 2009 BMES Annual Meeting, Pittsburgh, PA, October 7-10, 2009

52. Carney PR, Cadotte AJ, Ditto WL, Mareci T, DeMarse TB, Temporal Lobe Epilepsy: Anatomical and Effective Connectivity, Conference on Computational Neuroscience Gainesville, FL. 2/2008.

53. Cadotte AJ, DeMarse TB, Ditto WL, Carney PR, Granger Causality Analysis of Spontaneous Seizure in an Animal Model of Temporal Lobe Epilepsy, Pediatric Science Days, University of Florida (March 2008) Gainesville, FL.

54. Cadotte AJ, DeMarse TB, Mareci T, Talathi S, Hwang DU, Ditto W, Carney PR, Granger Causality Analysis of Spontaneous Seizure in an Animal Model of Temporal Lobe Epilepsy, Gordon Research Conference- Mechanisms of Epilepsy and Synchronization Waterville, ME. August, 2008.


55. Talathi SS, Dong-Uk Hwang, Ditto WL, Spano ML, Sepulveda H, Mareci T, Carney PR. Chronobiology of epilepsy, Nature, 2008.1679.1, 2008

56. Talathi SS, Dong-Uk Hwang, Ditto W, Carney PR. Loss of balance and circadian phase reversal in an animal model of limbic epilepsy, IEEE BMES, St Louis. 2008

57. Dong-Uk Hwang, Talathi SS, Winters J, Ditto W, Carney PR. Controlling firing activity of population spikes during epileptogenesis in an animal model of temporal lobe epilepsy, IEEE BMES, St Louis. 2008

58. Geyer JD and Carney PR. The association between acute cerebral infarction and restless legs. American Academy of Neurology 60th Annual Meeting, Chicago, April 12-19, 2008, Scientific Abstract Number 1548, Poster number P05.170

59. Kumar R, Barmpoutis A, Vemuri BC, Carney PR, Mareci TH. Multi-fiber reconstruction from DW-MRI using a continuous mixture of von misses-fisher distributions. IEEE Conf. on Mathematical Methods for Biomedical Image Analysis. June 2008

60. Zafar R and Carney PR. Gene therapy for temporal lobe epilepsy: the role of adeno-associated viral vector delivered s Carney PR. Somatostatin. Society for Neuroscience Annual Meeting, Platform, Wash D.C. 2008

61. Cadotte A. DeMarse T, Carney PR. Analysis of spontaneous temporal lobe seizures using granger causality. Society for Neuroscience Annual Meeting, Platform, Wash D.C. 2008

62. Parekh MB, Sepulveda, Hoang King M, Mareci T, Carney PR. Diffusion tensor MR imaging of a rat model of temporal lobe epilepsy. 38th Annual Meeting, Society for Neuroscience 15-19 Nov 2008

63. Zafar R, Carney PR. Adeno associated viral vector delivered somatostatin as a candidate for gene therapy for temporal lobe epilepsy. 62nd Annual Meeting of the American Epilepsy Society, Biennial North American Regional Epilepsy Congress, December 8, 2008 Platform Session #: A.08

64. Cadotte A, DeMarse T, Ditto W, Carney PR. In vivo causal analysis of initiation, propagation and termination of spontaneous temporal lobe seizure. 62nd Annual Meeting of the American Epilepsy Society, Biennial North American Regional Epilepsy Congress, December 8, 2008 Platform Session #: A.03

65. Talathi SS, Hwang DU, Cadotte A, Ditto WL, Carney PR. Imbalance in hippocampal network synchrony during epileptogenesis. 62nd Annual Meeting of the American Epilepsy Society, Biennial North American Regional Epilepsy Congress, December 6, 2008 Poster Session IW.O3

66. Hwang Dong-Uk, Talathi S, Carney PR, Ditto W, Myers S, Norman W, Simonotto J. High frequency oscillations in the limbic rat model of temporal lobe epilepsy, J. Computational Neuroscience, 2007

67. Bing J, Vemuri BC, Ozarslan E, Carney PR, Mareci T A novel tensor distribution for the diffusion weighted MR signal. IEEE International Symposium on Biomedical Imaging: From Nano to Macro. April 12-17, 2007

68. Talathi SS, Carney PR, Dong-Uk Hwang, Ditto W, Myers S, Simonotto J. High frequency oscillations in rat model of chronic limbic epilepsy, CNS, Toronto, Canada, July 2007.

69. Singh T, Little LE, Nathoo S, Snively C, Ringdahl D, Winger K, Jackson C, Carney PR, Liu Z, Borum P. Evaluating potential growth abnormalities in a patient population. Annual Meetings of the American Epilepsy Society and Canadian League against Epilepsy, 2006

70. Snively C, Carney PR, Liu Z, Ringdahl D, Winger K, Jackson C, Singh T, Little LE, Borum PR. Developing an Evidence-Based Ketogenic Therapy Program for Treatment of Epilepsy. Annual Meetings of the American Epilepsy Society and Canadian League against Epilepsy, 2006


71. Sepulveda H, Hoang-Minh L, Parekh MB, Hadlock A, Norman W, Sanchez JC, Ditto WL, Carney PR, Mareci T. Evolution of Temporal Lobe Epilepsy Observed with 11.1 Tesla MRI In Vivo. 60th Annual Meeting of the American Epilepsy Society, San Diego, CA, 2006

72. Parekh M, Hoang-Minh LB, Sepulveda H, Haddock A, Norman W, Sanchez JC, Ditto WL, Carney PR, Mareci TH. Diffusion Tensor MR Imaging of the Rat Model of Mesial Temporal Lobe Epilepsy. 60th Annual Meeting of the American Epilepsy Society, San Diego, CA, 2006

73. Nair SP, Norman WM, Dance L, Pardalos PM, Principe J, Carney PR. Development of Spatiotemporal Dynamical Transitions during Epileptogenesis. 60th Annual Meeting of the American Epilepsy Society, San Diego, CA, 2006

74. Zhang Q, Zhao Z, Liu, Carney PR, Jiang H. Imaging of Seizure-Onset Zone with Non-Invasive Photoacoustic Tomography in a Rat Model of Focal Seizures. 60th Annual Meeting of the American Epilepsy Society, San Diego, CA, 2006

75. Hoang-Minh L, Sepulveda H, Parekh M, Hadlock A, Norman W, Sanchez JC, Ditto WL, King MA, Carney PR, Liu Z, Mareci T. MRI Measurements at 17.6 Tesla in an Animal Model of Mesial Temporal Lobe Epilepsy Correlated with Histological Analysis. 60th Annual Meeting of the American Epilepsy Society, San Diego, CA, 2006

76. Bongiolatti SR, Fennell EB, Carney PR. Sleep Fragmentation and Disruptive Behaviors in Children with Epilepsy and Co-morbid Sleep Disordered Breathing. Journal of the International Neuropsychological Society 2006; 12(S1): 109

77. Geyer JD, Carney PR, Dillard SC. Epilepsy and Restless Legs Syndrome. 60th Annual Meeting of the American Epilepsy Society, San Diego, CA, 2006

78. Martynyuk, AE, Carney PR, Dennis DM, Laipis PJ. Mechanisms of Epileptic Activity in Phenylketonuria: Decreasing Levels of Phenylalanine Trigger Seizures. 60th Annual Meeting of the American Epilepsy Society, San Diego, CA, 2006

79. Loomis-Roux AR, Smith-Bonahue T, Carney PR. School Adjustment in Children with Epilepsy: Examining Parent Perceptions. 60th Annual Meeting of the American Epilepsy Society, San Diego, CA, 2006

80. Sanchez JC, Liu Z, Carney PR. Identifying the seizure onset zone using amplitude modulated slow potentials, gamma, fast gamma, and neural ensemble activity. 60th Annual Meeting of the American Epilepsy Society, San Diego, CA, 2006

81. Geyer JD, Carney PR, Dillard SC, Parrish P. Anti-depressant Medications, Neuroleptics and Prominent Eye Movements During. Sleep, Vol 29 Abstract Suppl. 2006 p. A34

82. Zhang QZ, Liu Z, Carney PR, Jiang HB, Imaging epilepsy using finite-based photoacoustic tomography: Initial in vivo results. Optical Society America Annual Meeting, Lauderdale, FL 2006

83. Singh, T, Little, LE, Nathoo S, Carney PR, Borum PB. Evaluating potential growth abnormalities in a patient population at Shands/UF on ketogenic therapy for seizures. Experimental Biology Meeting, 2006

84. Sanchez JC, Gunduz A, Carney PR, Principe JC. Extraction and localization of mesoscopic motor control signals for human ECoG neuroprosthetics. Neuroplasticity Conference, 2006

85. Sanchez JC, Principe JC, Carney PR. Choosing the Appropriate Level of Abstraction for Brain Machine Interfaces: Data Collection and Analysis Insights. DIMACS Workshop on Data Mining, Systems Analysis, and Optimization in Neuroscience, Feb 15-17, 2006

86. Carney PR. Dynamical EEG Properties in the Limbic Epilepsy Rat Model. DIMACS Workshop on Data Mining, Systems Analysis, and Optimization in Neuroscience, Feb 15-17, 2006

87. Bongiolatti SR, Fennell EB, Carney PR. Sleep Fragmentation and Disruptive Behaviors in Children with Epilepsy and Co-morbid Sleep Disordered Breathing, International Neuropsychological Society, Boston, MA, Feb. 3-6, 2006. 2(S1): 109, 2006


88. Shiau DS, Sackellares JC, Iasemidis LD, Nair SP, Norman W, Carney PR. Automated Seizure Warning in an Epileptic Rat Model. 57th Annual Meeting of the American Academy of Neurology, Miami FL, April 2005. Neurology 64 Suppl. 1 (Abs. A: 266), 2005

89. Stickler DE, Valenstein E, Neiberger RE, Perkins LA, Carney PR, Shuster JJ, Theriaque DW, Stacpoole PW. Peripheral neuropathy in genetic mitochondrial diseases. Muscle and Nerve, 57th Annual Meeting of the American Academy of Neurology, April 2005

90. Shiau DS, Iasemidis LD, Sackellares JC, Suharitdamrong W, Shenk D, Carney PR. Quantitative methods for distinguishing neonates at risk for seizures from normal newborns. PAS 2005: 57: 2655

91. Furman M, Ditto W, Simonotto J, Carney PR. High-Resolution Phase Tracking of Moving Epileptic Foci with Phase-Dynamic Quantification Analysis. Epilepsia 46 Suppl. 8:314 (Abs. 3.113), 2005.

92. Liu Z, Norman W, Shenk D, Carney PR. Similarity of electroencephalographic changes in a rat model of human temporal lobe epilepsy. Epilepsia 2005; 46 (8): 292

93. Bongiolatti S, Fennell E, Carney PR. Sleepiness as a Factor in Varying Degrees of Behavior Problems in Children with Epilepsy. Epilepsia 46 Suppl. 8:75 (Abs. 1.176) 2005

94. Simonotto J, Furman, Norman W, Sanchez J, Ditto W, Carney PR. Nonlinear Analysis of High-Resolution Microwire Electrode Data from a Chronic Limbic Epilepsy Model over the Latent Period. Epilepsia 46 Suppl. 8:124(Abst.2.098), 2005

95. Nair S, Shiau D, Pardalos PD, Iasemidis L, Sackellares JC, Carney PR. Dynamical Responses to Hippocampal Stimulation in a Rodent Model of Chronic Limbic Epilepsy. Epilepsia 46 Suppl. 8:332 Abs. 3.163, 2005

96. Sanchez J, Norman W, Mareci T, Carney PR. Multiscale Electrophysiological analysis and imaging in an animal model of limbic epilepsy. Epilepsia 46 Suppl. 8:10, 2005

97. Geyer JD, Carney PR, Gilliam F. Focal Dyshormia: Focal epileptiform spikes in conjunction with K-complexes. Epilepsia 46 Suppl. 8:27 (Abs. 1.041), 2005

98. Shiau DS, Liu C, Suharitdamrong W, Pardalos PM, Carney PR Sackellares JC. Distinguishing independent bitemporal form unilateral onset in epileptic patients by the analysis of nonlinear characteristics of EEG signals. Epilepsia 46 Suppl. 8:321 (Abs. 3.131), 2005

99. Carney PR, Nair SP, Iasemidis LD, Shiau DS, Pardalos PM, Shenk D, Norman WM, Sackellares JC. Quantitative analysis of EEG in the rat limbic epilepsy model. American Academy of Neurology 56th Annual Meeting, San Francisco, April 24-May 1, Poster P04.016, 2004

100. Sackellares JC, Iasemidis LD, Shiau DS, Yang CK, Dance LD, Pardalos PM, Carney PR. Automated seizure warning system performance in temporal lobe epilepsy. American Academy of Neurology, 56th Annual Meeting, San Francisco, April 24-May 1, Poster P02.033, 2004

101. Nair SP, Shiau DS, Norman WN, Shenk D, Suharitdamrong W, Iasemidis LD, Pardalos PM, Sackellares JC, Carney PR. Dynamical changes in the rat chronic limbic epilepsy model. Epilepsia 45 Suppl. 7:211 (Abs. 2.060), 2004

102. Shiau DS, Iasemidis LD, Yang MCK, Carney PR, Pardalos PM, Suharitdamrong W, Nair SP, Sackellares JC. Pattern-match regularity statistics-a measure quantifying the characteristics of epileptic seizures. Epilepsia 45 Suppl. 7:85 (Abs. 1.213), 2004

103. Furman, Michael, Sackellares. J Chris, Carney PR, Miliotis, Abraham, Simonotto, Jennifer, Ditto, William. Phase Tracking of Moving Epileptic Foci Using EEG and Phase-Dynamic Quantification Analysis. American Physical Society, March Meeting 2004, March 22-26, 2004, Palais des Congress de Montreal, Montreal, Quebec, Canada, MEETING ID: MAR04, abstract #V8.008.


104. Shiau DS, Iasemidis LD, Sackellares JC, Pardalos PM, Carney PR, Chaovalitwongse W. Nonlinear Dynamics and Global Optimization Approaches to Investigate Dynamical Transitions Before and After Epileptic Seizures. Quantitative Neurosciences Conference at University of Florida, February 5-7, 2003.

105. Sackellares JC, Iasemidis LD, Shiau DS, Carney PR., Pardalos PM, Chaowolitwongse W, Preictal Transition in Temporal Lobe Epilepsy. Quantitative Neurosciences Conference at University of Florida, February 5-7, 2003

106. Carney PR, Iasemidis LD, Sackellares JC, Srivastava A, Shiau DS, Maze MF, Zhang L, MacLennan AJ, Pardalos PM. Seizure Prediction by Nonlinear Times Series Analyses of Brain Electrical Activity in the H218 Animal Model. Quantitative Neurosciences Conference at University of Florida, February 5-7, 2003

107. Iasemidis LD, Sackellares JC, Pardalos PM, Shiau DS, Chaovalitwongse W, Carney PR. Epileptic Seizure Prediction. Quantitative Neurosciences Conference at University of Florida, February 5-7, 2003

108. Chaovalitwongse W, Pardalos PM, Sackellares JC, Iasemidis LD, Shiau DS, Carney PR. Nonlinear Dynamics and Global Optimization in EEG with Applications for Prediction of Epileptic Seizures. Quantitative Neurosciences Conference at University of Florida, February 5-7, 2003

109. Sackellares JC, Shiau DS, Pardalos PM, Carney PR, Chaowolitwongse W. Time Irreversibility of Brain Spatiotemporal Dynamics at Epileptic Seizure Transitions. International Nonlinear Sciences Conference, Vienna, Austria, February 7-9, 2003

110. Sackellares JC, Yang MCK, Iasemidis LD, Shiau DS, Pardalos PM, Carney PR. Real –Time Prospective Seizure Prediction and Statistical Assessment. NIH Biomedical Information Science Technology Initiative Consortium BISTIC, Bethesda, MD, Nov 6-7, 2003

111. Shiau DS, Sackellares JC, Iasemidis LD, Carney PR, Pardalos PM, Chaovalitwongse W. Dynamical Entrainment Among Epileptic Brain Areas, Ann Neurol. 2003; 54 (S7: S55)

112. Sackellares JC, Iasemidis LD, Shiau DS, Suharitdamrong W, Dance LK, Chaovalitwongse W, Pardalos PM, Carney PR. An Automated Seizure Warning Algorithm for Scalp EEG. Epilepsia 2003; 44 (9), 228

113. Carney PR, Sackellares JC, Shiau DS, Iasemidis LD, Chaovalitwongse W, Suharitdamrong W, Pardalos PM. Detection of Seizures in Newborns by Quantitative EEG Signal Analyses. Epilepsia 2003; 44 (9) 54-55

114. Sackellares JC, Yang MCK, Shiau DS, Iasemidis LD, Pardalos PM, Carney PR. Prospective controlled trial of an automatic seizure prediction algorithm. American Academy of Neurology 55th Annual Meeting, 2003. Neurology 60 Suppl. 1, Number 5, 2003

115. Saxonhouse MA, Bhatti MT, Driebe WT, Freeman BE, Maria BL, Carney PR. Primary antiphospholipid syndrome presenting with a branch retinal artery occlusion in a 15-year-old boy. J Child Neurol. 2002; 17(5): 392-4

116. Sackellares JC, Shiau DS, Iasemidis L, Pardalos P, Chaovalitwongse W, Carney PR. Can knowledge of cortical site dynamics in a preceding seizure be used to improve prediction of the next seizure? Annals Neurol. 2002; 52 (3S), S65-S66

117. Carney PR, Maze MF, Shiau DS, Srivastava A, Iasemidis LD, Pardalos PM, Sackellares, JC. State-specific nonlinear neurodynamic features in an animal model of generalized epilepsy. Epilepsia 43 Suppl. 7:270 (Abs. 3.063), 2002

118. Shiau DS, Sackellares JC, Iasemidis LD, Maze MF, Carney PR. Nonlinear Approximate Entropy Analysis of Brain Electrical Activity in a Generalized Epilepsy Animal Model. Epilepsia 2002; 443 (7): 27


119. Iasemidis LD, Shiau DS, Chaovalitwongse W, Pardalos PM, Carney PR, Sackellares JC. Adaptive Seizure Prediction System. Epilepsia 43 Suppl. 7:264 (Abs. 3.048), 2002

120. Chaovalitwongse W, Iasemidis LD, Prasad A, Shiau, DS, Pardalos PM, Carney PR, Sackellares JC. Seizure Prediction by Dynamical Phase Information from the EEG. Epilepsia 43 Suppl. 7:45 (Abst.1.121), 2002

121. Snively C, McLennan CS, Maze MF, Carney PR. Efficacy and tolerability of the ketogenic diet in the very young. Epilepsia 43 Suppl. 7:225 (Abs. 2.281), 2002.

122. Chaovalitwongse W, Iasemidis LD, Prasad A, Shiau DS, Pardalos, PM, Carney PR, Sackellares JC. Seizure prediction by dynamic phase information from the EEG. Epilepsia 2002; 443(7): 45.

123. Sackellares JC, Iasemidis LD, Shiau D-S, Chaovalitwongse W, Pardalos PM, Carney PR. Dynamic dependence of seizure prediction on preceding seizures. Epilepsia 43, Suppl. 7:50 (Abs. 1.136), 2002

124. Iasemidis LD, Shiau D-S, Chaovalitwongse W, Pardalos PM, Carney PR, Sackellares JC. Adaptive seizure-prediction system. Epilepsia 2002, 443(7): 264

125. Shiau DS, Sackellares JC, Iasemidis LD, Maze MF, Carney PR. Nonlinear approximate entropy analysis of brain electrical activity in a generalized epilepsy animal model. Epilepsia 2002; 443(7): 273

126. Muir A, Carney PR. Epilepsia partialis in a ketoacidotic child. Ann Neurol. 1999; 46:96.Tran TX, Palmer SC, Ni O, Iasemidis LD, Pardalos PM, Srivastava A, Won J, Shiau DS, Lee N, MacLennan AJ, Sackellares JC, Carney PR. Predictability of seizures in an epilepsy-prone transgenic mouse model, Epilepsia 2001; 42 (7): 225

127. Carney PR, Paige P. Neurologic Disorders. In: Handbook of Neonatal Intensive Care. Eds. Merenstein, GB, Gardner SL. Pub. Mosby, 5th ed. 2001; 644-678

128. Tran TX, Palmer SC, Ni OK, Muir AB, Carney PR. Epilepsia partialis continua as a presenting manifestation of diabetic ketoacidosis. Ann Neurol. 1999; 46: 96

129. Carney PR, Blaivas M, Drury I. Histopathological findings in a familial form of medically refractory temporal lobe epilepsy. Epilepsia 1998

130. Herrmann DN, Carney PR, Wald JJ. Juvenile myasthenia gravis: treatment with immune globulin and thymectomy. Pediatric Neurol. 1998; 18:63-66

131. Payne T, Kothary S, Varma N, Nasreddine W, Carney PR, Shu V, Beydoun A. Serum sodium and thyroid function after replacement of carbamazepine with oxcarbazepine. Epilepsia 1997; 3.023

132. Carney PR, Nasreddine W, Drury I, Varma N, Payne T, Shu V, Beydoun A. The relationship between thrombocytopenia and valproate dose. Epilepsia 1997; 3.054

133. Larson W, Carney P, Aldrich M. Atypical presentation of Leigh disease in a teenage woman. Mitochondrial Diseases Symposium. Indianapolis, Ind., 1995

134. Carney PR, Couve E. Cell polarity changes and migration during early development of the avian peripheral auditory system Fourth International Congress of Cell Biology (Montreal). 1988; 7.2.28

135. Carney PR, Silver J, Manubens L. Cell migration and axon guidance in the developing rat auditory system. 3rd Regional Chile Biol. Soc. 1983; 4:10

136. Carney PR., Silver J. A mechanism for the guidance of peripheral spiral ganglion cell axons in the developing mouse auditory system. Soc. Neurosci. XVI, 1980; 6:487


Commentary:

Chaovalitwongse WA*, Iasemidis LD, Pardalos PM, Carney PR, Shiau DS+, Sackellares JC. Reply to comments on Performance of a seizure-warning algorithm based on the dynamics of intracranial EEG by Mormann, F., Elger, C.E., and Lehnertz, K. Epilepsy Res. 2006 Oct: 71(2-3): 241-2

PRESENTATIONS (Selected)

National and International:

1. Florida Pediatric Epilepsy Network 1st Annual Conference, Invited Speaker: “Cannabidiol in Pediatric Epilepsy and in Florida”, Orlando, Florida, June 9-11, 2016

2. University of Illinois, Department of Neurology and Rehabilitation, Grand Rounds, Invited Speaker: “Therapeutic Devices for Drug-Resistant Epilepsy”, May 28, 2015.

3. NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. Florida Symposium on the BRAIN Initiative, UF Brain Institute and Scripps Institute, Invited Speaker: “Mapping Brain Networks with Optical Imaging Tools”, January 17, 2014

4. 13th Curso International de Neuropsiquiatria Infantile. Viña del Mar, Chile, Keynote speaker: “Mitos y Realidades en Autismo”, May 30-31, 2014

5. The Epileptic Brain Map, University of Chicago, Department of Pediatrics, November 15, 2013

6. Mapping the Epileptic Brain: Implications for Treatment and Repair, Rutgers University, Department of Neurology and Neuroscience, October 1, 2013

7. Neural Networks in Epilepsy 2013 Spring Physiological Sciences Seminar Series (VME 6932), University of Florida, March 26, 2013

8. UF 2013 Physiological Sciences Spring Seminar Series, Neural Networks. March 26, 2013

9. Distinguished Invited Honorary Speaker, Georgia Academy of Science, Neural Networks in Epilepsy: Evidence of and Implications for Treatment, March 29, 2013, Valdosta, GA

10. Invited Speaker, UF MD/PhD Candidate Talk. A Neuroscientist’s Journey to Reverse Engineer the Human Brain. February 18, 2013

11. Neural Networks in Epilepsy: Evidence of and Implications for Treatment. UF Neuroscience Seminar Series GMS 7794, January 21, 2013

12. Neural Networks in Epilepsy. University of Vermont, Burlington VT. November 12, 2012

13. Neural Networks in Epilepsy: Evidence of and Implications for Treatment. Saint Lois University, October 11, 2012

14. Epilepsy in the Presence of Sleep Disorders. Phoenix Children's Hospital/Barrows Neurological Institute, Phoenix, Arizona. August 2012

15. Noninvasive Functional and Cellular Imaging of Epilepsy. The Neurological Institute of New York Columbia University Medical Center, New York, November 21, 2011

16. 5th International Seizure Prediction Workshop, September 19-23, 2011, Dresden, Germany

17. Cleveland NEW Neural Engineering Workshop, June 16-17, 2011, Cleveland, Ohio

18. Emerging Therapies in Epilepsy, American Pediatric Society Outstanding Invited Science by New Members Symposia, Denver, CO, May 1, 2011

19. Circadian Regulation of Neural Excitability in Temporal Lobe Epilepsy. Nocturnal Frontal Lobe Epilepsy: An Interdisciplinary Perspective. National Institutes of Health Office of Rare Diseases Research and Alliance for Epilepsy Research. Sanibel Symposium. Sanibel, FL, February 11-12, 2010


20. Optogenetics Deconstruction of Hippocampus Epileptic Neural Circuitry. American Clinical Neurophysiology Society, Annual Meeting San Diego, CA, February 2-7, 2010

21. Neural Interface for Repair and Treatment of Epilepsy, Department of Neurology Grand Rounds, Wake Forest University, December 15, 2009

22. Curing Epilepsy: Progress and Future Directions, Grand Rounds, Medical College of Milwaukee, Milwaukee, WI, December 13, 2010

23. Neural Interface for Repair and Treatment: Potential for Epilepsy, Grand Rounds, Emory University/Georgia Tech, Atlanta, Department of Neuroscience, September 9, 2008

24. 4-D Neuroimaging 3rd Annual International Users Group Meeting, Barcelona, Spain, July 13-15 2008

25. 7th Curso International de Neuropsiquiatria Infantile. Viña del Mar, Chile, May 30-31, 2008

26. XXIX Annual Child Neurology Postgraduate Course Miami Children’s Hospital. Topics: Sleep and Epilepsy and Epilepsy Co-Morbidity. Miami, Florida. May 2, 2008

27. Neural Interface for Repair and Treatment: Potential for Epilepsy, Mt Sinai School of Medicine, New York, NY, September 17, 2007

28. Third International Seizure Prediction Workshop, Talk: Dynamics of a Limbic Epilepsy Model, Freiburg, Germany. September 30-October 4, 2007

29. State Key Laboratory of Brain and Cognitive Science Institute of Psychology, Chinese Academy of Sciences. Topic: Sleep disorders in children and adults. Beijing, China, November. 15, 2007

30. Capital Medical University Beijing Tiantan Hospital. Topic: Brain Machine Interface for Epilepsy. Beijing, China, November 15, 2007

31. International Conference on Translational Research, Peking Union Medical College Hospital (PUMC), Topic: Neural Interface for Repair and Treatment: Potential for Epilepsy. Beijing, China, November 11-13, 2007

32. Invited Participant, 4-D Neuroimaging 2rd Annual International Users Group Meeting, Denver, June 6-8, 2007

33. 60th Annual Meeting of the American Epilepsy Society, Sensing the Brain; Engineering Special Interest Group, Topic: Neural Prosthetic for Epilepsy, San Diego, CA. December 1, 2006

34. Florida Neurological Society, Topic: Epilepsy Behavioral and Cognitive Co-Morbidity in Pediatric Epilepsy: Recognition, Mechanisms, Assessment and Treatment. Orlando, Florida, December 14, 2006

35. 23rd Congreso de Psiquiatria y Neurologia de la Infancia y la Adolescencia. Topics: Seizure Prediction; Emerging Technologies for Epilepsy: Diffusion Tensor Imaging and Photoacoustic Tomography. Viña del Mar, Chile, South America, October 12-14, 2006

36. Fourth International Sleep Disorders Forum Rome, Italy, 7-8 September, 2006

37. DIMACS Workshop on Data Mining, Systems Analysis, and Optimization in Neuroscience, Gainesville, FL, Topic: Dynamical EEG Properties in the Limbic Epilepsy Rat Model, February 15-17, 2006

38. Chilean Pediatric Society, Chile, 1st International Iberoamerican Pediatric Neurology Conference, Topics: Childhood Epilepsy and Childhood Sleep Disorders, October 6, 2005

39. American Academy of Neurology, Miami, FL, Topic: Seizure Prediction in a Limbic Model of Temporal Lobe Epilepsy, May 2, 2005

40. University of Valparaiso, Society for Pediatric Neurology, Topics: Pharmacoresistant Childhood Epilepsy and Evaluation and Treatment of Sleep Disorders, June, 2004


41. Grand Rounds, University of Arkansas, Department of Pediatrics. Topic: Modeling and Seizure Prediction, May 12, 2004

42. Grand Rounds, University of Florida, Department of Pediatrics, Jacksonville, FL, Title: Catastrophic Childhood Epilepsy: Advances in Diagnosis and Management, April, 23, 2004

43. The First International Collaborative Workshop on Seizure Prediction, International Seizure Prediction Group, Bonn, Germany. Topic: Seizure Prediction in a Generalized Epilepsy Animal Model, March, 10, 2003

44. University of Chile and University of Valparaiso, Chilean Pediatric Neurology Society, Valparaiso, Chile, 1st International Iberoamerican Pediatric Neurology Conference, Topics: Childhood Epilepsy and “Childhood Sleep Disorders, March 22, 2003

45. Recent Advances in Modeling and Prediction of Epileptic Seizures, Grand Rounds, Department of Neurology, Case Western Reserve University, Cleveland, OH, March 1, 2002

46. Practical Approach to the Diagnosis and Management of Sleep Disorders, North Florida Neurological Society, February 13, 2002

47. American Epilepsy Society Annual Meeting, Special Interest Group and Participatory Roundtable, New Orleans, LA. Topic: Brain Dynamics in Rat Chronic Limbic Epilepsy Model, December 2, 2001

48. Predictability of seizures in a transgenic epilepsy-prone mouse model, Spring Epilepsy Research Conference, Cayman Islands, Platform session, April 25, 2001

49. Sleep disordered breathing during childhood: diagnosis and treatment, Nemours Children Foundation Grand Rounds, Jacksonville, March 8, 2001

50. Update on Epilepsy: Consensus Conference in Child Neurology, Orlando, FL, Management of medically refractory seizures, University of Florida, Department of Pediatrics, February 18,1999

51. Temporal lobe epilepsy surgery during childhood. Neurology Grand Rounds, State University of New York, Buffalo, NY, February 1, 1998

Local:

1. Epilepsy: From Bench to Bedside, Grand Rounds, University of Florida Department of Pediatrics, Dec 17, 2010

2. Biomedical Engineering Update: University of Florida College of Engineering, Department of Biomedical Engineering Advisory Board Meeting, October 17, 2008

3. American Association of Critical-Care Nurses. Swamped with Knowledge 2008. Topic: To Seize or Not to Seize: That is the Question, Gainesville, Florida, March 1, 2008

4. Conference on Computational Neuroscience 2008. Topic: Temporal Lobe Epilepsy: Anatomical and Effective Connectivity. University of Florida, Center for Applied Optimization, Gainesville FL February 20, 2008

5. Neural Interface for Repair and Treatment: Potential for Epilepsy, University of Florida Department of Neuroscience, January 16, 2008

6. Data Mining, Systems Analysis & Optimization in Biomedicine University of Florida College of Engineering, March 28-30, 2007

7. Neuroscience Grand Rounds, Topic: Pathophysiology of Temporal Lobe Epilepsy, University of Florida, February 5, 2006

8. Conference on Data Mining, Systems Analysis and Optimization in Neuroscience University of Florida. Topic: EEG Dynamics in an Animal Model of Temporal Lobe Epilepsy, February 15-17, 2006.


9. College of Engineering Recruitment, University of Florida, Gainesville, FL Topic: Brain Dynamics and Neural Networks in Epilepsy, February 17, 2006

10. Research Seminar Grand Rounds, Department of Physical Medicine and Rehabilitation, University of Florida, Gainesville, FL Topic: Brain Machine Interface for Epilepsy, September 14, 2005

11. Conference on Systems Analysis, Data Mining, and Optimization in Biomedicine, Topic: Dynamical Characteristics in Rat Chronic Limbic Epilepsy Model, University of Florida, Gainesville, FL. February 4, 2005

12. Quantitative Neuroscience/Neural Engineering Seminar, University of Florida, Neonatal Seizures, March 2, 2004

13. Children’s Medical Services, Nursing Symposium, Topic: Childhood Sleep Disorders: Evaluation and Management, April 5, 2004

14. Conference on Data Mining in Biomedicine, Center for Applied Optimization, Modeling and Computation for Engineering, Science and Industry, College of Engineering, University of Florida, Gainesville, Topic: A Quantitative EEG Method for real-time Detection of Neonatal Seizures in the Neonatal Intensive Care Unit. February 16-18, 2004

15. Florida Chapter AAP Annual Meeting and Florida Pediatric Alumni Association Annual Meeting, Topic: Recent Advances in the Diagnosis and Treatment of Pediatric Epilepsy. June 20, 2003

16. Biomedical Research Partnership seminar series. Colleges of Medicine and Biomedical Engineering. University of Florida. Talk: Seizure prediction in the H218 sphingosine 1-phosphate mouse model. January 15, 2002

17. Children’s Miracle Network, Radio Telethon Fund Raiser. Interview reviews medical needs of children with complex neurologic problems, including epilepsy, sleep disorders, and developmental delay, August, 2001

18. Children’s Miracle Network, TV 20, Personal Portrait: Sara Higgins. Story reviews the personal experience of an 8-year-old child with refractory epilepsy undergoing a presurgical and surgical evaluation for epilepsy surgery, June, 2001

19. University of Florida/Shands Hospital Epilepsy Surgery Patient Reunion, Topic: New Anticonvulsant Drugs, September 11, 2000

20. Health in a Heartbeat radio program on WUFT-FM (Classic 89), Topic: Spinal muscular dystrophy, February 4, 2000

21. Public Relations, A Question of Health” TV 20, Theme: Sleep Disorders, Panel Member, January 17, 2000

22. University of Florida College of Medicine medical student and pediatric house officer rural medicine expedition and course (Nicaragua). Group leader: Donald Eitzman, M.D., February 9, 1999

23. Evaluation and Treatment of the Seizing Child, University of Florida, Emergency Medicine Clinical Lecture, August, November 12, 1998 Cephalon, Inc., Speaker Bureau on Sleep Disorders Sleep Disorders. East Side Community Health Center: Florida representative Karen Chestnut, Acute repetitive seizures and other epileptic emergencies: management strategies, University of Florida, Department of Pediatrics, September 30, 1998

24. Pediatric epilepsy surgery; evaluation and management, University of Florida pediatric nursing in-service, August 29, 1998


TEACHING ACTIVITIES

University of Florida Colleges of Medicine and Engineering

Course Director:

E25, Pediatric Neurology, UF Department of Pediatrics, Fall, Spring, Summer, 2009-2016

BME 6010, Biomedical Engineering Clinical Preceptorship, UF College of Engineering, 15+ students, Fall, Spring, Summer 2005-2015

Lecture to Graduate Students, Fellows, Postdoctoral:

GMS-6029: Neurodegenerative Research: From Bench-to-Bedside, Spring, 2012-2016

MDU 4001 – Translational Neuroscience, 2005-2016

MS6007, Neuroscience Course UF Department of Neuroscience, Fall, 2004-2016

EML7980 – Doctoral Research, 2002-2016

Doctoral Advanced Research, 2002-2016

Continuing Education Lectures:

Teaching attending physician, Ped Neurology Series Dept. of Neurology, UF, 07/01/98-06/15/16

In-patient teaching attending, Pediatric Neurology, University of Florida, 07/01/98-06/15/16

Out-patient teaching attending, Ped Neurology, Epilepsy/Sleep Disorders Clinic, UF, 07/01/98-06/15/16

Lecturer, Neonatal Fellows Seminar Conference, Div. of Neonatology, Department of Pediatrics, 07/01/98-06/15/16

General pediatrics morning conference attending, Department of Pediatrics, University of Florida, 07/01/98-06/15/16

Lecturer, Pediatric Neurology Morning Conference, Department of Pediatrics, University of Florida, 07/01/98-06/15/16

Lecturer, Epilepsy, Clinical Neurophysiology, and Sleep Medicine, UF Department of Neurology, 07/01/98-06/15/16

Lecturer, Neuroscience course GMS 6007, University of Florida Department of Neuroscience, 07/01/98-06/15/16

Lecturer, Physiology Graduate Level Course, UF Department of Biomedical Engineering, 07/01/98-06/15/16

Lecturer, School of Physician Assistant Studies, University of Florida College of Medicine, 07/01/98-06/15/16

Lecturer, Shands Epilepsy Laboratory, Neonatal seizures, 07/01/98-06/15/16

Lecturer, University of Florida School of Physician Assistant Studies, 07/01/98-06/15/16

Research Teaching:

BME7980 Doctoral research, credits 9, 2002 to 2016

ENG 4912 Engineering research, 2002-2016

Honors independent research (undergraduate) 4917, 2002 to 2016

BME6907 Biomedical engineering project, credits 3, 2002 to 2016

BME6971 Masters research, credits 9, 2002 to 2016

BME7979 Advanced research, credits 9, 2002 to 2016


PHA7979 Advanced research, credits 9, 2002 to 2016

EML7980 Doctoral research, credits 9, 2002 to 2016

ZOO4905-Individual studies, 2011, 2012

Clinical Teaching:

Inpatient and outpatient pediatric and adult residency, pediatric neurology fellowship, clinical neurophysiology/epilepsy, 1998-2016

Student Preceptorships:

MEL 4012 Undergraduate Physician Shadowing Program, 2005 to 2016

MUD 4004 Fall, 2013, 2014

Graduate Supervision as Chair (Doctoral):

1. Chris Anderson, Cannabidiol and drug resistant epilepsy: Network changes, January, 2017

2. Gowri Natarajan, Somatostatin overexpression in epilepsy, December 2016

3. Frank Delgado, Convection enhanced delivery in brain tumors, August 2016

4. Nikita Agarwal, Near-infrared optical imaging, December 2015, current employment: Brucker Imaging

5. David Stanley, Hippocampal circadian rhythms in temporal lobe epilepsy, August 2013, current employment: postdoctoral fellow Boston University

6. Matt Shore, Nano control of channelrhodopsin-2, May 2012, current employment: Google, Inc.

7. Jason Winters, Cooling device for seizure prevention, May 2012, current employment: Department of Defense

8. Eric Bennett, Optogenetics for seizure control, May 2012, current employment, scientist at UCSF

9. Svetlana Kantorovich, Convection enhanced drug delivery in epilepsy, May 2012, postdoctoral fellow at UC Irvine, current employment, Proove, Inc.

10. Rabia Zafar, Epilepsy and gene therapy, December 2010, current employment, pediatric resident at Washington University St. Louis

11. Mansi Parekh, High-field magnetic resonance imaging and epileptogenesis in an animal model of limbic epilepsy, December 2010, current employment: postdoctoral fellow at Stanford University

12. Stephen Meyers, Closed-loop seizure prevention, September 2010, current employment: Patent Attorney Law School and Technical Specialist at Foley & Lardner LP, Boston

13. Susan Bongiolatti, Frontal lobe dysfunction in childhood epilepsy and cognitive problems in children with sleep disorders and epilepsy, December 2008, current employment: assistant professor Case Western Reserve University

14. Sandeep Nair, Quantitative EEG signal analysis in rat limbic epilepsy model, June 2007, current employment: biomedical engineer at Biogen, Inc.

15. Daniel Becker, Relation between sleep and epilepsy in children, May 2002, current employment: assistant professor at the University of Pennsylvania

Graduate Supervision as Chair (Masters):

1. Nikolai Dosev, Brain dynamics and epilepsy, August 2014

2. Gowri Natarajan, Somatostatin overexpression in epilepsy, May 2013

3. Maria Zildani, Current source identification in vagal nerve stimulation therapy, May 2013


4. Frank Delgado, Convection enhanced delivery in brain tumors, August 2013

5. Brandon Doan, Machine learning and seizures, December 2013

6. Matt Shore, Light sensitive nanoparticles in optogenetics, December 2012

7. Stefano Re Fraschini, Circadian variations in hippocampus of epileptic rats, August 2012

8. Sonam Chheda, Gene therapy in epilepsy, May 2012

9. Stephen Myers, Seizure detection in epilepsy, August 2009

Graduate Committees as Member (Doctoral):

1. Ana Bohorquez, Nanotherapy in diffuse infiltrative pontine gliomas, TBA

2. Magdoom Kulam Najmudeen. Convection enhance delivery and epilepsy, TBA

3. Jeffrey Leibowitz, Progenitor cells in epilepsy SST treatment, TBA

4. Shengpo Fang, Carbon Nanofiber (CNF) neural probe, March 27, 2017

5. Aditya Kasinadhuni, MR electrical impedance tomography flow, November 2016

6. Wei Dai, Convection enhanced delivery modeling in epilepsy, June 2015

7. Tao Zhang, Diffusion optical tomography and epilepsy, May 2015

8. Liju Ji, Photoacoustic tomography and epilepsy, December 2014

9. Shivakeshavan Ratnadu, Computational model for epileptic networks, December 2014

10. Shruthi Bharadwaj, Model for IBD, December 2013

11. Manu Nandan, Fast SVM Training using approximate extreme points, September 2013

12. Vikram Munikoti, Unraveling the Vascular Niche: A study of the extracellular matrix in niche regulation of adult hippocampal neurogenesis, August 2013

13. Luis Colon, Weighted networks and the topology of brain networks, July 2013

14. Rachel Speisman, Identifying inflammatory biomarkers of cognitive aging through relationships between measures of inflammation, neurogenesis and cognition in aged rats, May 2013

15. Gonzalo Fernando Casanova Garcia, Evaluation of the effect of needle insertion speed in convection-enhanced delivery into the rat brain, May 2013

16. Lan Hoang-Minh, Circadian control of adult neural progenitor cell behavior in vivo and in vitro: a molecular and genetic screen of regulatory candidates for neurodegenerative therapies, December 2012

17. Katherine Follansbee-Junger, Examining the contribution of health behaviors and psychological functioning and antiepileptic drug induced weight gain among children with epilepsy, June 2012

18. Anit Salgia, Automatic quantification from CT scans of morphological changes in pulmonary arterial vasculature in pulmonary artery hypertension. February 2012

19. Siddharth Ray, Perpendicular fiber tracking for fiber bundle analysis. February 2012

20. Phil Barish, Design and functional evaluation of an optically active mu opioid receptor: A step towards an optogenetic therapy for pain, December 2011

21. Garrett Astary, CED for epilepsy, December 2011

22. Mackenzie Hoffmann, Expanding the role of cannabinoids in the synaptic physiology of the hippocampus, August 2010

23. Hector Sepulveda, Diffusion tensor imaging and epilepsy, May 2010

24. Amy Roux, School attitudes toward childhood epilepsy August 2009


25. Chang Chia Liu, Brain dynamics, system control and optimization techniques with application in epilepsy, August 2008

26. Anil Bollimunta, Techniques for analysis of neural activity: spontaneous and evoked, June 2008

27. Mandy Layman, Ketogenic diet in intractable childhood epilepsy, June 2008

28. Nicole Nasewicz-Pies, Recognizing, differentiating, and referring students with absence seizures: what factors affect pre-service teachers’ decision-making? May 2008

29. Chelsey Durgin, Diffusion tensor imaging and epilepsy, May 2008

30. Alex Cadotte, Non- linear dynamics for discrimination of pharmaceutical agents on MEA's, August 2007

31. Sandeep Nair, Seizure prediction using Lyapunov exponents, December 2006

32. Sobra Fritz, Network model for epilepsy epidemiology, December 2003

33. Hector Sepulveda, MRI and epilepsy, December 2000

34. Tran Ai Hang, Ketogenic diet efficacy in epilepsy, June 2000

35. Jodi Passman, Ketogenic diet and epilepsy, June 1999

Graduate Committee as Member (Master’s):

1. Christine Girard, Diffusion tensor imaging in epilepsy, August, 2013

2. Ankit Salgia, May 2012

3. Siddharth Ray, May 2012

4. Lauren Jones, Ketogenic diet in epilepsy, May 2011

5. Edgard Andrade, Granger causality in epilepsy, May 2011

6. Adam Fletcher, A computational study of flow and mass transport in intrathecal drug delivery, August 2010

7. Mamta Wankhede, Micro vascular changes in tumor genesis, December 2010

8. Lan Hoang Minh, DTI in epilepsy, May 2008

9. Amanda Layman, Ketogenic diet in childhood epilepsy, December 2004

10. Tran Hang, Modified ketogenic diet in childhood epilepsy, August 2000

Graduate Committee as External Doctoral Committee Member:

1. Xinyue Liu, Epidemiological model in childhood epilepsy, October 2015

2. Taylor Kuhn, Relation between memory and brain structure, December 2014

3. Manu Nandan, Seizure detection, December 2013

4. Gonzalo Casanova, Convection enhanced delivery in epilepsy, August 2013

5. Katherine Junger, Ketogenic diet in refractory epilepsy, August 2012

6. Sheng-Feng Yen, Photoacoustic tomography and epilepsy localization May 2011

7. Lauren Jones, Ketogenic diet and epilepsy, August 2009

8. Nicole Nasewicz, Ketogenic diet in refractory childhood epilepsy, May 2009

9. Gregg Selke, ADHD and epilepsy, August 2005

Postdoctoral Teaching:

1. Gowri Natarajan, Ph.D., University of North Carolina at Chapel Hill, January 2017 – present


2. Junli Zhao, M.D., Ph.D., University of Florida, Neuroscience, University of Florida, Spring 2008-Spring 2016, Current Employment: Research Biologist, University of North Carolina, Chapel Hill

3. Stephen Myers, Ph.D., Biomedical Engineering, Current Employment: Food & Drug Administration, Spring 2011-Winter 2012, research assistant professor at Boston University

4. Rabia Zafar, Ph.D., M.D. Neuroscience, Current Employment: Medical Student University of Central Florida, Spring 2011-Spring 2012, Current Employment: Pediatric Resident at Washington University

5. Mansi Parekh, Ph.D., Biomedical Engineering and Neuroscience, University of Florida, fall 2011 to Fall 2014. Current Employment: Research Assistant Professor at Stanford University

6. Fernando Casanova, Biomedical Engineering, Current Employment: Assistant Professor Columbia University (Bogota), Spring 2011 to 2013 (Fulbright Scholarship)

7. Sachin Talathi, Ph.D., Biomedical Engineering, Current Employment: Assistant Professor, UCSD and Qualcomm, Inc., Fall 2006 to Spring 2008

8. Dan Tarquinio, D.O, Pediatric Neurology, Current Employment: Miami Children’s Hospital, Fall 2007 to Spring 2008, Current Employment: Assistant Professor at Emory University

9. Alex Cadotte, Ph.D., Biomedical Engineering, Current Employment: FDA, Fall 2008 to Spring 2011

10. Wendy Norman, D.M.V., Ph.D. Neuroscience, Current Employment: Faculty, University of Florida Dept. Veterinary Medicine, Spring 2003 to Fall 2008

11. Greg Selke, Ph.D., Neuropsychology, Current Employment: Faculty Brown University, Providence, RI, Fall 2005 to Spring 2007

12. Justin C. Sanchez, Ph.D., Biomedical Engineering, Employment History: Associate Professor, University of Miami Department of Biomedical Engineering, Currently, Director DARPA (BTO), Fall 2004 to Spring 2006

Clinical and Masters Supervision:

1. Edgard Andrade, M.D., Department of Pediatrics, Functional Connectivity in Epilepsy, 06/2008 to 12/2011

2. Dan Tarquinio, M.D., Department of Pediatrics, Tourette’s syndrome 6/2009 to 07/2010

Medical Student Mentorship:

1. Yeong Jung Park, Summer Fellowship, University of Florida College of Medicine Medical Student Research Program; Project: Identifying Structural and Functional Correlates in Children and Adults with Medically Intractable Epilepsy, Medical Student, UF College of Medicine, 2010 to 2012

2. Phillip Chong, Summer Fellowship, University of Florida College of Medicine College of Medicine Medical Student Research Program, Project: Identification of a Structural Biomarker for Childhood Epilepsy, Medical Student, UF College of Medicine, Summer, 2011

3. Christa Matrone, University of Florida College of Medicine Pediatric Resident, Boston Children’s Hospital, Fall 2011, Current Position: Pediatric Resident Children’s Hospital Boston

4. Kathryn Helmick, University of Florida College of Medicine Project: Epilepsy and Animal Models, University of Florida, 2008 to 2009

5. Jenny Wilkerson, Summer Fellowship, University of Florida College of Medicine Medical Student Research Program; Project: Relationship between sleep disturbance and daytime behavioral problems in children with epilepsy, Summer 2008


Junior Honors Medical Program:

1. Shahrukh Bengali, University of Florida College of Medicine, September 2014 to July 2016

2. Angelique Boutzoukas, University of Florida College of Medicine, Sept 2012 to June 2014

Clinical Fellows Mentored:

1. Liliana Petrova, M.D., Pediatric house officer. 2003 to 2004

2. George Gacibieu, M.D., Fellow in clinical neurophysiology, 2003 to 2004

3. Brenda Wu, M.D., Ph.D., Fellow in clinical neurophysiology, 2000 to 2001

4. Terry Bunch, M.D., Fellowship in pediatric neurology, 1998 to 1999

Clinical Fellows Supervised: 25+ Total

Interdisciplinary Neuroscience Program Undergraduate Students Supervised:

1. Christian Svetics, IDH 4917 (Spring, 2014)

2. Ahmad Ahmad, IDH4905 (Fall, 2013, Spring, 2014)

3. Jessica McElroy, Thesis: Epilepsy Gene Therapy, Current Position: Medial Student Nova University, Fall 2009 to Spring 2012

4. Kami Veltri, Thesis: DTI Imaging, Current Position: Medical student GW University (Spring 2009 Fall 2011)

Formal Undergraduate Student Research Supervision - BMS4905 (50+ Total)

Crisp Advisor (Exchange Graduate Program with University of Milan (2 Total)

High School Students Supervision UF Student Science Training Program: Jonathan Im, Project: Brain White Matter Connectivity and its Correlation to Neurological Disease and Dysfunction Summer, 2011, Currently an undergraduate student at Duke

University of Florida Pediatric Neurology/Pediatric Attending on Clinical Service:

Pediatrics, 5 to 6 residents every 4 weeks, 1998 to 2016

Pediatric neurology, 2 fellows per year, 8 to 12 weeks per year, 1998 to 2016

Adult neurology, 1-2 residents per week, 8 to 12 weeks per year, 1998 to 2016

Clinical neurophysiology and epilepsy, 1 fellow per year, 8 to 12 weeks inpatient EMU and 1 day per week reading EEG, EP, PSG studies, 1998 to 2016

Various – nursing students, pharmacy students, undergraduate studies. At least 1 student per 8 to 12 week in patient rotation. Outpatient 1-2 full days, 1998 to 2016

Grand Rounds (Last 5 years):

University of Illinois (Chicago), Department of Neurology and Rehabilitation, Grand Rounds, Therapeutic Devices for Drug-Resistant Epilepsy”, May 28, 2015

The Epileptic Brain Map, University of Chicago, Department of Pediatrics, November 15, 2013

Mapping the Epileptic Brain: Implications for Treatment and Repair, Rutgers University, Department of Neurology and Neuroscience, October 1, 2013

Neural Networks in Epilepsy, University of Vermont, Burlington VT, November 12, 2012

Epilepsy in the Presence of Sleep Disorders, Phoenix Children’s Hospital/Barrows Neurological Institute, Phoenix, Arizona. August 2012

Neural Networks in Epilepsy: Evidence of and Implications for Treatment”, Saint Louis University, Saint Lois, Missouri, October 11, 2012

Epilepsy: From Bench to Bedside, Grand Rounds, UF Department of Pediatrics, December 17, 2010


Selected Community Outreach and Mentoring Activities:

Health Care and Life Sciences Council, The Greater Gainesville Region CEO Council for Economic Outreach, May 24, 2017

Free Clinic physician volunteer, Alachua County Migrant Workers Program (1 session every 2-3 months) May 2013 to June 2016

High school students’ supervision, University of Florida Student Science Training Program, summer, 2011, 2012, 2015

Scientific Judge, Lincoln Middle School Science Fair, Gainesville, FL, winter, 2005 to 2016

State of Florida Medical Advisor to the Florida Birth-Related Neurological Injury Compensation Assoc., Tallahassee, FL, May 15, 2003 to August 30, 2008

University of Florida College of Medicine medical student and pediatric house officer rural medicine expedition (Nicaragua), February 1-15, 1999

University of Michigan

Fellow Lecturer, Neurology resident’s neuroscience course, 8 lectures, July, 1996 to June, 1998

University of Valparaiso School of Medicine

University of Valparaiso School of Medicine, Department of Cell Biology, Neuroscience Lecture series, Director: E. Couve, March 1990 to December 1992

RESEARCH SUPPORT Active:

Title: 5EP01 Effects of cannabidiol use on the developing brain in medically refractory childhood epilepsy Agency: Florida Department of Health Role: PI (6/04/15-6/15/16) Subcontracted PI (6/16/16-6/30/18) Effort: 4.2 calendar months Period: 06/04/2015 – 06/30/2018 Total Funding: $1,000,000 Goals: The goal of this study is to provide treatment with cannabidiol (CBD) to children with drug resistant epilepsy through an Expanded Access Investigation New Drug protocol. Additional objectives include evaluation of cognitive and adaptive behaviors in children taking CBD in combination with antiepileptic drugs, structural and function MR with EEG, and development of an online portal to disseminate information to enhance health care providers’ knowledge and facilitate family understanding about CBD for epilepsy.

Title: W81 XWH-13-1-0256 Translational advancement of somatostatin gene delivery for disease modification and cognitive sparing in intractable epilepsy Agency: Department of Defense (2012 Congressionally Directed Medical Research Programs Peer Reviewed Medical Research Program Investigator-Initiated Research Award) Role: MPI (King, Ormerod) Effort: 3 calendar months Period: 09/01/2013-08/31/2018 Total Funding: $1,430,804 Goals: This project will examine potential mechanisms of action underlying the action of somatostatin gene transfer on epileptogenesis. Inflammation, plus the generation and integration of new brain cells, are the primary mechanisms that will be investigated. Title: Investigator initiated study: Preclinical investigation of Epidiolex for autism spectrum disorder brain connectivity and behavior Agency: GW Pharma Role: PI


Effort: 1.2 calendar months Period: 02/15/17-06/30/18 Total Funding: $245,000 Goals: To test the hypothesis that CBDV improved autistic behaviors through reconfiguring functional brain networks. Pending: Title: Somatostatin gene delivery to enhance long-term functional recovery from traumatic brain injury Agency: CDMPR Department of Defense Role: PI Effort: 3 calendar months Period: 10/01/17 – 09/30/21 Total Funding: $1,259.093 Goals: To test the hypothesis that somatostatin gene therapy improves neurologic outcome in traumatic brain injury by modulating inflammation and neural progenitor cell production. Title: R03 DA042971 Preclinical imaging of adolescent cannabidiol on brain structure and functional connectivity Agency: National Institutes of Health (NIDA) Role: PI Effort: 1.0 calendar month Period: 10/01/17 – 09/30/19 Total Funding: $150,000 Goals: The objective of the proposal is to determine the behavioral and neuroimaging effect of cannabidiol exposure during adolescence in an animal model of autism spectrum conditions Impact score: 17 Completed:

Title: R01NS077004-01 Direct functional imaging of electrical brain stimulation Agency: National Institutes of Health (NINDS) Role: PI (ASU PI, Sadleir) Effort: 1.2 calendar months Period: 03/15/2014 – 06/30/2016 Total Funding: $2,028,216 Goals: Non-invasive functional neuroimaging is a critical element of attempts to understand structure and function in the brain. In this study, we will establish the feasibility of a technique that uses a more robust and direct contrast mechanism than functional MRI to examine neural activity. Title: R21NS081646-01 In vivo imaging of therapeutic electric current flow Agency: National Institutes of Health (NINDS) Role: PI (ASU PI, Sadleir) Effort: 1.2 calendar months Period: 07/01/2014 – 06/30/2016 Total Funding: $462,302 Goals: Electrical stimulation therapies such as deep brain stimulation (DBS) and transcranial direct current stimulation (tDCS) are increasingly being used to affect motor function, cognitive processing, and executive function. Little is understood of the mechanisms or actual electrical current flows Title: Somatostatin gene delivery to enhance long-term functional recovery from TBI Agency: Department of Veterans Affairs, Rehabilitation R&D SPiRE grant Role: Co-PI (King) Effort: 0.5 calendar months Period: 2014-16


Total funding: $200,000 Goals: To test the efficacy of somatostatin gene therapy for traumatic brain injury.

Title: PR080678 Photoacoustic Imaging of Epilepsy Agency: CDMRS Advanced Technology/Therapeutic Development Award Period: 04/01/2009 to 03/31/2014 Total Funding: $1,490,551 Role: PI (MPI, Contact PI Jiang) Effort: 1.8 calendar months Goals: To test a new optimal imaging method for understanding the cellular and network changes underlying seizure onset and spread. To design, construct and test a fast multispectral optical system for functional/cellular PAT imaging; (2) To develop a set of image enhancement schemes for improved DOT imaging of small animals, and To develop both linear and nonlinear models that couple the electrophysiological recordings with the hemodynamic/cellular response measured by PAT; (3) To evaluate and optimize the integrated functioning of the hardware and software components of the multispectral PAT system, using simulation and phantom experiments; (4) To test and evaluate the proposed PAT system and neuro-vascular/neuro-cellular coupling models using animal models. Title: 5R01NS069848-04 Noninvasive functional and cellular imaging of epilepsy Contact PI / Agency: National Institutes of Health (NINDS) Period: 02/15/2010 to 01/30/2015 Total Funding: $1,136,626 Role: Co-PI Effort: 1.8 calendar months Goals: To test a new optimal imaging method for understanding the cellular and network changes underlying seizure onset and spread. To design, construct and test a fast multispectral optical system for functional/cellular DOT imaging; (2) To develop a set of image enhancement schemes for improved DOT imaging of small animals, and To develop both linear and nonlinear models that couple the electrophysiological recordings with the hemodynamic/cellular response measured by DOT; (3) To evaluate and optimize the integrated functioning of the hardware and software components of the multispectral DOT system, using simulation and phantom experiments; (4) To test and evaluate the proposed DOT system and neuro-vascular/neuro-cellular coupling models using animal models.

Title: R01 NS063360 Computational Transport Models for Convection-Enhanced CNS Delivery Agency: The National Institutes of Health (NINDS) Role: MBI (Sarntinoranont) Effort: 2.4 calendar months Period: 09/29/2008 - 07/31/2014 Total Funding: $1,490,551 Goals: In this study, our goal is to provide fundamental understanding of CED transport of compounds into the hippocampus for the treatment of temporal lobe epilepsy (TLE). The study clarifies the roles of extracellular flow, tissue anisotropy, pathological changes, tissue swelling, and backflow. MR-based bio-transport tools provide an important step towards patient-specific treatment since they account for anatomical and structural changes with disease. There is no overlap between this work and the proposed work.

Title: R01-EB004752 Collaborative Research in Computational Neuroscience: Evolution into Epilepsy Agency: National Institutes of Health Dates: 09/01/04 – 06/30/10 Direct: $1,287,170


Role: MPI (Ditto) Effort: 2.4 calendar months Goals: The basic project goals are to use our computational algorithms and models to evaluate potential hypothesis on the underlying functional and structural mechanisms of epileptogenesis in a validated animal model of temporal lobe epilepsy. Title: R01 EB007082 CRCNS: Automatic Prediction of the Onset of Epilepsy via Analysis of HARDI Agency: National Institutes of Health (NIBIB) Dates: 08/01/06- 05/31/10 Direct: $1,296,877 Role: MPI (Vermuri) Effort: 1.8 calendar months Summary: The major goals of this study are to develop a computational algorithm for MR high angular resolution diffusion imaging de-noising and estimation of the field of probability densities. Then to develop and validate an atlas-based segmentation scheme that allows computation of fiber tracts and the signatures of structural changes, during the period of epileptogenesis, and predicts the time of onset of epilepsy. Title: R21 NS060862 Balanced Polyvalent Anti-Glutamatergic Action as a Novel Approach to Efficacious Neuroprotection Agency: National Institutes of Health (NINDS) Dates: 09/15/08 – 06/30/10 Direct: $325,000 Role: Co-I (Martynyuk) Effort: 1.0 calendar months Summary: This study tests the hypothesis that in newborn rats, anesthetics that enhance GABA A/glycine receptor activity may depolarize the neuronal membrane potential, trigger seizures, and cause neurotoxicity.

Title: R01-NS050582 On-Line Real-Time Seizure Prediction Agency: National Institutes of Health (NINDS) Dates: 09/01/02 – 06/30/05 Direct: $2,382,724 Role: Co-PI (Sackellares) Effort: 3 calendar months Goals: To develop a seizure prediction methods or individuals with temporal lobe seizures. Title: RO1 Dichloroacetate Kinetics, Metabolism and Toxicity Agency: National Institutes of Health Dates: 07/01/04 to 06/30/09 Direct: $1,800,000 Role: Co-I (Stacpoole) Effort: 1.0 calendar month Goals: This multicenter study investigates the natural history of childhood mitochondrial cytopathy. DCA is employed as experimental compounds in order to ameliorate the effects of lactic acidosis.

Title: An EEG Method for Real-Time Detection of Neonatal Seizures in the NICU Agency: Epilepsy Foundation of America Partnership for Pediatric Epilepsy Research Foundation Dates: 05/01/03 – 04/30/06 Total funding: $75,000 Role: PI Goals: To develop a system for detecting seizures in newborns.


Title: R21 HD 044981Outcome of Therapeutic Hypothermia in Pediatric Arrest Agency: National Institutes of Health Dates: 06/30/03-07/01/06 Total funding: $290,000 Role: Co-PI Effort: 1.0 calendar month Goals: This is a planning grant to develop methods for assessing hypothermia in cardiac arrest. Title: R01 EB002089 Bioengineering Research Partnership in Brain Dynamics Agency: National Institutes of Health Dates: 07/19/01 to 04/30/07 Total funding: $3,825,000 Role: Co-PI (Sackellares) Effort: 3.0 calendar months Goals: The goal of the Brain Dynamics Bioengineering Research Partnership was to develop an on-line, real-time Automated Seizure Warning and Prevention System for use by epileptic patients and their caregivers.

Sponsorship (Mentor) of Postdoctoral Fellowships:

Title: Preclinical Investigation of CBDV for Autism Spectrum Disorder Brain Connectivity & Behavior Agency: GW Pharma (Investigator Initiated Study) Role: Mentor Effort: 0.8 calendar cost share Period: 10/01/2016 – 12/31/2017 Total award: $225,000 Goals: To assess the endocananaboid systems changes in functional connectivity and behavior in autism.

Title: Goodman Trust Award 2011 Agency: Child Neurology Society Recipient: Phillip Chong Medical Student Dates: 06/15/11 to 08/15/11 (summer scholarship) Role: Medical student mentor Effort: 0.8 calendar cost share Total award: $2,500 Title: Goodman Trust Award 2010 Agency: Child Neurology Society Recipient: YJ Park Medical Student Dates: 6/1/2010 to 5/31/2011 Role: Medical student mentor Effort: 0.8 calendar cost share Total award: $2,500

Title: Subcortical Executive Function and Frontal Lobe Childhood Epilepsy Agency: Epilepsy Foundation of America Dates: 07/01/2004 to 6/30/2005 Role: Postdoctoral research mentor for Sachin Talathi, PhD Effort: 0.8 calendar cost share Total award: $40,000 Intramural Grants:

Title: Control of Neural Synchrony with Light-Activated Opsins Working Group


Agency: University of Florida Computational Biology Working Group Seed Grant RFA Dates: 04/01/10 to 03/31/11 Role: Co-PI (Carney/Khargonekar/Talathi) Effort: 1.2 calendar months Amount: $100,000 Title: Novel Anti-Epileptic Drug Discovery: Somatostatin Receptor Modulation for Treating Epilepsy Agency: Research Opportunity Fund Competition, Division of Sponsored Research, University of Florida Dates: 09/01/04-06/30/06 Role: PI Effort: 1.0 calendar month Amount: $100,000 Title: On-Line Real-Time Seizure Prediction in Adult Patients with Epilepsy Agency: Office of Technology Licensing, University of Florida Division of Sponsored Research Dates: 04/15/04-03/30/05 Role: Co-PI Effort: 0.8 calendar month Amount: $26,872 Title: Dynamical On-Line Real-Time Seizure Warning and Treatment in an Epilepsy-Prone Rodent Model Agency: University of Florida Division of Sponsored Research Opportunity Fund Role: PI Effort: 0.6 calendar month Dates: 07/01/01 – 06/30/02 Amount: $50,000 Title: Pre-ictal detection and seizure prevention in a transgenic mouse model of childhood epilepsy Agency: Children’s Miracle Network Dates: 06/30/01- 07/01/02 Effort: 0.5 calendar month Amount: $1,000 Role: PI Effort: 0.7 calendar month Title: Pediatric EEG/Sleep Agency: Children’s Miracle Network Grant # 2000-044 Amount: $3,330 Dates: 05/01/00- 04/30/01 Role: PI Effort: 0.5 calendar month Title: In Vivo Neurophysiologic Characterization of the Epilepsy-Prone Sphingosine 1 Phosphate Receptor H218 Knockout Mouse Agency: Children’s Miracle Network Grant Amount: $40,000 Dates: 08/15/00- 07/01/01 Role: PI Effort: 0.5 calendar month Dynamical Studies in Generalized Childhood Epilepsy Agency: Biomedical Engineering Program


Dates: 08/30/9- 06/30/00 Role: PI Effort: 0.5 calendar month Amount: $25,000 Title: The Relationship between Sleep-Related Breathing Disorders and Hearing in Children Epilepsy Surgery Program Agency: Children’s Miracle Network Grant # 99S-035 Intramural Patient Amount: $16,700 Dates: 09/01/99 – 06/30/00 Role: PI Effort: 0.5 calendar month Goals: The goals of this project were to assess the impact of hearing loss in children with sleep disorders. Title: Sleep Disorders Center Agency: Children’s Miracle Network Grant # 99S-056 Amount: $7,500 Dates: 09/15/99-06/30/00 Role: PI Effort: 0.5 calendar month Title: Role: PI Pediatric Epilepsy Program Agency: Children’s Miracle Network Grant # 98HS-001 Dates: 09/02/98- 05/15/99 Amount: $2,587 Role: PI Effort: 0.5 calendar month Title: Epilepsy Monitoring Program Agency: Children’s Miracle Network Grant # 98HF-015 Dates: 09/01/98 – 06/30/99 Amount: $48,000 Role: PI Effort: 0.5 calendar month Industry Sponsored Grants: Title: Heart Rate Changes in Epilepsy E-30-S Agency: Cyberonics, Inc. Dates: 05/25/11 – 09/01/13 Role: PI Effort: 0.5 calendar month Amount: $550,705 Title: Evaluation of the efficacy and tolerability of Levetiracetam add on treatment in refractory pediatric patients with partial onset seizures Funding Agency: GlaxoSmithKline Grant # LAM40013 Dates: 07/01/02-06/30/03 Role: PI Effort: 0.5 calendar month Total Award: $58,000 Title: A multicenter, open label conversion of valproate monotherapy to lamotrigine monotherapy in patients with epilepsy


Funding Agency: GlaxoSmithKline Grant # LAM 40013 Dates: 06/15/02- 06/30/04 Role: PI Effort: 0.5 calendar month Total Award: $77,000 Title: A multi-center open label, pilot study of lamotrigine as adjunctive therapy and monotherapy in patients with epilepsy and co morbid depressive symptoms Funding Agency: GlaxoSmithKline Grant # LAM40117 Dates: 05/30/02- 06/30/03 Role: PI Effort: 0.5 calendar month Total Award: $37,000 Title: A multicenter, open-label study to investigate the pharmacokinetics of commercial lacosamide oral formulations as therapy in children (aged 1 month to 17 years) with epilepsy SP1047 Agency: UCB Biosciences, Inc. Dates: 07/01/01- 04/01/02 Role: PI Effort: 0.5 calendar month Total Award: $15,000 Title: A multi-center, double blind, randomized, placebo-controlled, parallel-group evaluation of lamotrigine adjunctive therapy in subjects with primary generalized tonic-clonic seizures Funding Agency: Glaxo-Wellcome, Inc. Dates: 10/15/01-09/15/02 Role: PI Effort: 0.5 calendar month Total Award: $21,000 Title: In patient Rufinamide as adjunctive therapy in children and adults with inadequately controlled partial seizures Funding Agency: Novartis, Inc. Dates: 06/15/00- 04/30/01 Role: PI Effort: 0.5 calendar month Total Award: $18,500 Title: Rufinamide as adjunctive therapy in children and adults with inadequately controlled partial seizures Funding Agency: Novartis, Inc. Dates: 11/01/98- 09/30/99 Role: PI Effort: 0.8 calendar month Total Award: $41,800 Title: A Multicenter, Double-Blind, Placebo-Controlled, Randomized, Stratified, Parallel-Group Trial of the use of Telecommunications in Evaluating Compliance in Teen Epilepsy Agency: NIH Dates: 09/01/98- 10/30/03 Role: PI Effort: 0.25 calendar month Total Award: $31,600


Title: Ketogenic Eggnog versus Ketogatornog Treatment for Seizures Agency: Ross Foods, Inc. Dates: 10/01/98-06/01/01 Role: PI Effort: 0.25 calendar month Total award: $3,500 Patents and Invention Disclosures:

1. Justin Sanchez and Paul R. Carney. Closed-Loop Micro-Control of Epileptic Neuronal Activity, Issued Patent No: 8,374,696. 2013.

2. Sachin S. Talathi, Dong-Uk Hwang, William L. Ditto, Paul R. Carney, Mark Spano. Method and System for Detecting Epileptogenesis, Issued Patent No: 8,447, 407. 2013

3. Guenther Hochhaus and Paul R. Carney. Valproic Acid Derivative Compounds. UF3-13715, 2011

4. Sachin S. Talathi, Paul R. Carney, Dong-Uk Hwang, William L. Ditto. Detecting Epileptogenesis. Attorney Docket No.: 450-P0005US, 2010

5. Thomas Harold Mareci, Paul Richard Carney, Garrett William Astary and Hector Sepulveda. Magnetic Resonance Compatible and Susceptibility-Matched Apparatus and Method for MR Imaging and Spectroscopy. Application Number 61/232,288, 2009

6. William Ogle and Paul R. Carney. Optically Active Opioid Receptors for the Treatment of Chronic/Acute Pain. Application Number 13317, 2009

7. Ditto, WL, Carney PR, Talathi S, Hwang, DU. Neuromodulation of Excitation and Inhibition to Control Epilepsy and Neurological Disorders. Invention disclosure UF # 12785 2008

8. Paul R. Carney, J. Chris Sackellares, Deng Shiau. Real-Time Brain Monitoring System. Patent Number 7433732. 2008

9. Sackellares JC, Principe JC, Shiau DS, Pardalos PM, Carney PR, Cho J, Nair SP Suharitdamrong W and Dance LK. “State Dependent, Direct and Model-based Closed-loop Seizure Control System”. UF invention disclosure # – 11926, 2005

10. Justin Sanchez and Paul R. Carney. Closed-Loop Micro-Control System for Predicting and Preventing Epileptic Seizures. UF Provisional Patent UF#- 63815P (49163), 2005

11. Paul R. Carney, J. Chris Sackellares, Deng Shiau. Real-Time Brain Monitoring System. Patent UF#-#-11220, 2005

12. Sackellares JC, Carney PR, and Shiau DS. Interactive Dynamical Brain Monitoring and Neuro Diagnostic Systems. Attorney Docket No. 028724-144.001United States Patent Application Number 11/065,703, 2004

13. Paul R. Carney, MD, J. Chris Sackellares, MD, Deng Shiau, Ph.D. Real-Time Brain Monitoring System. UF Provisional Patent UF#-11220, 2003

14. J. Chris Sackellares, MD, Paul R. Carney. Multi-Dimensional Multi-Parameter Time Series Processing for Seizure Warning & Prediction. Provisional Patent UF#-No 028724-143, 2003

PROFESSIONAL SERVICES

Editorial Boards:

Associate Editor, Journal of Pediatric Neurology, April 2014 to present

Editorial Board, Journal of Materials Science and Chemical Engineering, August, 2013 to present

Associate Editor, Children, September 2012 to present

Editorial Board, Recent Patents on Biomedical Engineering, March, 2007 to present


Associate Editor, Computers in Biology and Medicine, September 2005 to present

Editorial Advisory Board, Photoacoustic Tomography, 2013

Associate Editor, Journal of Pediatrics, 2007 to 2013

Scientific Review Panels:

Member, NIH Acute Neural Injury and Epilepsy Study Section, July 01, 2017 to June 30, 2021

Ad Hoc Reviewer, University of Florida Division of Sponsored Research, Research Opportunity Fund Advisory Committee, American Epilepsy Society Research, 2005 to 2016

Ad Hoc Reviewer, NIH Acute Neural Injury Epilepsy, June, 2016

Ad Hoc Reviewer, Computational Neuroscience Society, April, 2016

Ad Hoc Reviewer, NIH Brain Injury and Recovery, March, 2016

Ad Hoc Reviewer, Canadian Institutes of Health Research, January 2016

Ad Hoc Reviewer, NIH, Neurobiology of Mental Disorders and Addictions, July, 2015

Ad Hoc Reviewer, Study Section Epilepsy and Related Diseases, November, 2015

Chair, NIH Study Section Neurogenetics, Epilepsy, Technology, Neural Repair. October, 2014

Ad Hoc Reviewer, Medical Research Council, European Union, March 2014

NIH Reviewer, NIH Director's Early Independence Award Review, June, 2012

Ad Hoc Member, NIH Study Section Epilepsy: Imaging, Surgery and Sleep Disorders, April, 2012

Ad Hoc Member, NIH Study Section Small Business: Clinical Neurophysiology, Devices, Auditory Devices and Neuroprosthesis, July, 2011

Chair, National Institutes of Health, NINDS, NIH ZNS1 SRB-B 31 Study Section, July 27, 2011

Ad Hoc Member, NIH Study Section ZNS1 SRB-B (31) July, 2011

Member, NIH Study Section Neurotechnology NT-B, February, 2011

Ad Hoc Member, NIH Study Section Small Business: Clinical Neurophysiology, Devices, Auditory Devices, and Neuroprosthesis, March, 2011

Advisory committee, Canadian Research Council, 2011

Co-Chair, NIH Study Section SBIR ETTN-K 10, February, 2010

Member, NIH Study Section Small Business: Clinical Neurophysiology, Devices, Auditory Devices and Neuroprosthesis, June, 2010

A Ad Hoc Reviewer, Graduate Student for Outstanding Research, Office of Graduate Education, Office of the Dean, College of Medicine, University of Florida, June 2009

d Hoc Reviewer, NIH Study Section Clinical Neurophysiology, Devices, and Neuroprosthetics, June, September 2007, February, June, October 2008, March 2009

Ad Hoc Reviewer, NIH Study Section Neurotechnology Study Section Emerging Technologies and Training Neurosciences Integrated Review Group, October 2008, Feb 2009

Ad Hoc Reviewer, Natural Sciences and Engineering Research Council of Canada, August, 2007, July, 2008

National/Professional Services Activities:

Advisory Board Member, Epilepsy Foundation’s National Professional Advisory Board, March 2014 to present

Mentor, American Epilepsy Society Junior Faculty Mentoring Program, 2010 - present


Mentor, American Pediatric Society Leadership Mentoring Program, 2013, 2016

Member, American Neurological Association Scientific Committee abstract reviewer, 2013

Mentor, American Pediatric Society Leadership Mentoring Program, 2013

American Epilepsy Society Pediatric Content Committee, December 2009-12

American Academy of Neurology Scientific Program Committee, 2008-12

American Epilepsy Society Scientific Program Committee Member, 2007-12

Elected, American Pediatric Society ‘Most Outstanding’ New Member Award, 2011

Elected Board Member, Florida Epilepsy Foundation, 2011

Chair, Society for Neuroscience Annual Meeting Nanosymposium on Optogenetics Tools Washington DC, 2011

Member, American Neurological Association136th Annual Meeting Scientific Program Committee, San Diego, CA, 2011

Member, American Academy of Neurology's Scientific Program Committee Subcommittee – Sleep Disorders (Toronto), 2010

Chair, Society for Neuroscience Clinical Epilepsy Nanosymposium, 2010

Fourth International Workshop on Seizure Prediction Scientific Advisor Committee, 2009

American Epilepsy Society Special Interest Group Committee Member, 2001

Invited Platform Moderator - American Epilepsy Society, 1998

National and Local Committee Professional Assignments and Service:

Alachua Multi-County Migrant Education Program, 2014 to 2015

UF Graduate Student Mentoring Award application reviewer, November, 2015

Florida Symposium on the NIH BRAIN Initiative May, 2014

UF EEG and Epilepsy Monitoring Unit Advisory Committee Shands Children’s Hosp. 1998-2012

Member, Regional Training, Children Medical Services North Central Region invited talk on Pediatric Neurology, November 18, 2011

Member, University of Florida College of Medicine MD/PhD Educational Program, Spring 2009

Advisory Board, University of Florida COE Dept. Biomedical Engineering, October 16-17, 2008

Member, University of Florida College of Medicine Neurology Chair search committee, Fall 2008

Advisory Board, DIMACS Workshop on Data Mining, Systems Analysis, and Optimization in Neuroscience, University of Florida, Gainesville, FL 2006

Advisory Committee, Conference on Data Mining, Systems Analysis and Optimization in Neuroscience, February 15-17, 2006. University of Florida

Academic Graduate Committee, Department of Biomedical Engineering, UF COE, 2005-06

Search Committee for Department of Biomedical Engineering, UF College of Engineering, 2004-06

Co-Organizer, Conference on Systems Analysis, Data Mining, and Optimization in Biomedicine, University of Florida February 2-4, 2005

Ad Hoc Advisory Board Member, Dept. Biomedical Engineering, UF COE, May, 2005

Advisory Board, Data Mining in Biomedicine, University of Florida College of Engineering, 2004-05

Co-Organizer, Center for Applied Optimization, University of Florida, College of Engineering and McKnight Brain Institute, 2004-05


Department of Pediatrics Outpatient Clinic Planning Committee, Fall 2000- Summer 2004

Member, Department of Bioengineering Faculty Search Committee, Univ. of Florida COE, 2003

Member, University of Florida McKnight Brain Institute Director search committee, 2003

Conference Co-organizer, Quantitative Neuroscience: Models, Algorithms, Diagnostic and Therapeutic Applications Conference, University of Florida, 2003

Department of Neurology Epilepsy Faculty search committee, University of Florida Division of Critical Care Faculty search committee, Department of Pediatrics, University of Florida, Fall 2003

UF Sleep Disorders Program Planning Committee Shands Children’s Hospital, Fall 2000

University of Florida Sleep Disorders Program Planning Committee, 2000

Department of Pediatrics Strategic Planning Committee, Fall 2000

RESEARCH STATEMENT

Goals and Philosophy

The goals of my research program are as follows: continue to develop a diverse and productive research program in translational neuroscience and neural engineering; provide a strong scientific basis for new therapies for neurological disease; train graduate, undergraduate, postdoctoral fellows and physician scientists in research, neuroscience, and neural engineering.

A central theme of my work is that I combine engineering and neuroscience with medical research to develop more effective therapies for neurological disease. This leverages my experience as both a clinician scientist and engineer. The passion that drives my career is the search for better ways to prevent and treat epilepsy which affects over 60 million people worldwide.

I lead a long-term effort to define structural and functional biomarkers of epileptic networks and seizure generation to enable more precise diagnostics and effective antiepileptic therapies. Because effective treatment and cure in epilepsy typically require an understanding of neural systems and fundamental processes, my research strives to combine studies of basic questions with applied research. Our goal is to advance the translation of biomedical discoveries into

applications that improve clinical outcomes. Although my research spans the continuum from

basic to applied questions, it focuses mostly on systems neuroscience and provides a strong scientific basis for implementing antiepileptic strategies.

As principal investigator and co-investigator on federal, institutional, and privately funded grants, I engage and innovate in the areas of signal processing, computational neuroscience, brain imaging, and gene therapy. Clinical translation is an important goal of my work, in addition to mentoring clinicians and scientists across fields. Involvement of graduate students and postdoctoral fellows is a critical aspect of my research program. Through the research process, I strive to train students in basic concepts, research methodology, management strategies, and philosophies of science. I also take enjoyment from expanding my research program horizons in new areas of the world and with new research questions and technologies.

I have 15 years of experience in applying tools from dynamical systems theory to understand brain network organization as estimated from structural and functional data from a wide range of modalities including ECOG, electrode microarrays, MRI, fMRI, DTI, PAT, and DOT in humans and animal models of epilepsy. In our computational neuroscience work, we seek to implement new mathematical methods and models for the characterization of temporally dynamic, spatially embedded, and multiscale network systems, with the goal of predicting epileptic system behavior and designing perturbations to characterize and treat individuals with epilepsy. In applications to neurophysiology data, we implement analytic tools to probe the hard-wired pathways and transient neural communication patterns in an effort to identify organizational principles, to develop novel diagnostics, and to design personalized therapeutic prevention and treatment.


A large portion of our work focuses on quantifying the dynamical system changes during the evolution into epilepsy and during seizures. My program is fundamentally interdisciplinary and greatly facilitated by collaborations with research scientists around the world from diverse backgrounds including applied mathematics, control theory, physics, electrical engineering, computer science, statistics, neuroscience, neurology, and psychology.

Contributions to Science

A. Seizure Detection, Prediction, and Nonlinear Dynamical System Theory. Historically, electrocorticography studies of human epilepsy have predominantly focused on qualitative and linear approaches to understand changes in local field potential activity prior to and during seizures, and more recently functional connections between those regions. We have taken a pointedly dynamical systems approach to characterize the evolution of epilepsy and seizure dynamics. In collaboration, we define and test new algorithms to detect and predict seizures, and characterize brain states. We learned that seizure onset is preceded by specific changes in nonlinear brain dynamics, and that individual differences predict seizure onset and spread. This work has the potential to impact personalized seizure prevention strategies in the context of treatment refractory epilepsy.

Many epileptic syndromes are thought to occur as a result of acquired brain injury, genetic aberrations, or disorders of neurodevelopment. Temporal lobe epilepsy, for example, is understood to be a chronic neurological disorder that leads to local as well as large-scale neural dysconnectivity. We take a systematic dynamical approach of the relationship between electrophysiology, bifurcations, and computational properties of neurons. We also implement network representations of structural and functional connections between brain areas to characterize alterations in the topological organization of the brain, and we link these alterations to advance understanding of epilepsy and its comorbid conditions such as depression, cognitive and behavioral abnormalities.

1. Ying-Cheng L, Lanzhou LN, Ditto W, Spano M, Carney P, Lai YC. Detecting and characterizing high frequency oscillations in epilepsy. R. Soc. open sci. 2017:4:160741.

2. Carney PR, Myers, S, Geyer JD. Seizure prediction: methods. Epilepsy & Behavior. 2011 Dec; 22 Suppl 1: S94-S101.

3. Nandan M, Talathi SS, Myers S, et al. Support vector machine algorithms for seizure detection in an animal model of chronic epilepsy. J Neural Eng. 2010 Jun; 7(3): 036001.

4. Nair SP, Shiau DS, Principe JC, et al. An investigation of EEG dynamics in an animal model of temporal lobe epilepsy using the maximum Lyapunov exponent. Exp. Neurol. 2009; 216(1): 115-21. Talathi SS, Hwang DU, Ditto WL, et al. Non-parametric early seizure detection in an animal model of temporal lobe epilepsy. J. Neural Eng. 2008 Mar; 5 (1): 85-98.

5. Iasemidis LD, Shiau DS, Pardalos PM, et al. Long-term prospective on-line real-time seizure prediction. Clinical Neurophysiology. 2005; 116 (3): 532-544.

B. Functional Organization of Brain Circuitry. Historically, computational studies of epilepsy have predominantly focused on macroscopic level resolution ECOG, and more recently functional connections between those regions. We have taken a dynamical system level approach to characterize connectivity patterns during seizure onset and propagation. We observe that the immediate the pre-seizure state displays rapid reconfiguration of functional network dynamics, evident in across time scales in both local field recordings and resting state functional connectivity, that differ between healthy and epileptic states. We and others also observe that these changes occur on the setting of a stable, intrinsic dynamical pattern, suggesting that the brain might transition to diverse dynamical states. This work has the potential to provide diagnostic biomarkers for seizures and serve to guide more effective closed-loop seizure prevention strategies.

1. Yang H, Zhang T, Zhou J, et al. In vivo imaging of epileptic foci in rats using a miniature probe integrating diffuse optical tomography and electroencephalographic source localization. Epilepsia. 2015 Jan; 56(1): 94-100.


2. Tang J, Zhou, J, Huang H, et al. Non-invasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats. J Cereb Blood Flow Metab. 2015 Jun 17.

3. Zhang T, Zhou J, Carney PR, Jiang H. Towards real-time detection of seizures in awake rats with GPU-accelerated diffuse optical tomography. J Neurosci Methods. 2015: 240:28-36.

4. Boykin ER, Khargonekar PP, Carney PR, et al. Detecting effective connectivity in networks of coupled neuronal oscillators. J. Comput. Neurosci. 2012 Jun; 32(3): 521-38.

5. Cadotte AJ, DeMarse TB, Mareci TH, et al. Granger causality relationships between local field potentials in an animal model of temporal lobe epilepsy. J Neurosci. Methods. 2010 May 30; 189 (1): 121-9.

C. Structural Organization of Brain Circuitry. For decades, neuroscientists have been seeking fundamental principles of brain organization. With recent advances in network science, imaging, molecular biology, and optogenetics, new answers to these systems-level questions are within reach. We have constructed realistic computational models from ECoG, chronic microelectrode recordings, optical imaging, and ultra-high-field brain imaging data that summarize the dynamics and connections between specific brain regions. We use these data to inform theories about brain organization and disease states. We have also leveraged our understanding about structural organization in epilepsy to develop and test computational models of small molecules distribution and clearance, and electrical stimulation paradigms for rehabilitation and treatment in epilepsy.

1. Kuhn T, Gullett JM, Nguyen P, et al. Test-retest reliability of high angular resolution diffusion imaging acquisition within medial temporal lobe connections assessed via tract based spatial statistics, probabilistic tractography and a novel graph theory metric. Brain Imaging Behav. 2016 Jun;10(2):533-47.

2. Colon-Perez LM, Spindler C, Goicochea S, et al. Dimensionless, scale invariant, edge weight metric for the study of complex structural networks. PLoS One. 2015 Jul 14; 10(7): e0131493.

3. Colon-Perez LM, King M, Parekh M, et al. High-field magnetic resonance imaging of the human temporal lobe. NeuroImage: Clinical. 9: 2015; 58-68.

4. Kantorovich S, Astary GW, King MA, et al. Influence of acute brain injury status epilepticus on convection-enhanced delivery in the rat hippocampus. PLoS One, 2013 Nov 8; 8(11): e80606.

5. Kim JH, Astary GW, Kantorovich S, et al. Voxelized Computational Model for Convection Enhanced Delivery in the Rat Ventral Hippocampus: Comparison with In Vivo MR Experimental Studies. Ann Biomed. Eng. 2012; 40: 2043-58.

D. Control of Brain Hyperexcitability. Cortical activity reflects the interplay of synaptic excitation and inhibition. Accumulating evidence emphasizes the important role of somatostatin (SOM) in shaping the neural homeostatic excitation inhibition balance. In several neurologic disorders including epilepsy, SOM interneurons substantially decline, which inevitability leads to hyperexcitability. In an attempt to restore the excitation inhibition balance, we have taken a unique approach in which SOM is overexpressed by AAV-mediate gene expression in hippocampus in a model of limbic seizures. Our results suggest that over expression of SOM by gene delivery ameliorates hippocampus hyperexcitability and prevents seizures. We use these results to design more efficient AAV-SOM constructs, study adverse effects, and potential benefits in epilepsy-associated cognitive problems.

1. Natarajan G,* Leibowitz JA,* Zhou J, Zhao Y, King MA, Ormerod BK, Carney PR. Adeno-associated viral vector-mediated preprosomatostatin expression suppresses induced seizures in kindled rats. Epilepsy Res. 2017 Jan 7;130:81-9.

2. Shivakesavan-Giridharan S, Stefenscau RA, Khargonekar PP, et al. Genesis of interictal spikes in the CA1: a computational investigation. Frontiers in Neural Circuits, 2014 Jan 27; 8:2.


3. Zafar R, King MA, Carney PR. Adeno associated viral vector-mediated expression of somatostatin in rat hippocampus suppresses seizure development. Neurosci Lett. 2012: 509: 87-91.

4. Ji L, Zhou J, Zafar R, Kantorovich S, et al. Cortical neurovascular coupling driven by stimulation of channelrhodopsin-2. PLoS One. 2012; 7(9): e46607.

5. Talathi SS, Carney PR, and Khargonekar PP. Control of neural synchrony using channel rhodopsin 2: a computational study. J Comput Neurosci. 2011 Aug; 31(1): 87-103. Epub 2010 Dec 21

E. Sleep Disorders and Circadian Rhythm. Since the late 19th century, clinicians have been aware that epileptic seizures are predisposed to occur at specific times of day. Recent experiments by our group in a chronic limbic epilepsy animal model further support the hypothesis that epilepsy following brain injury is strongly influenced by circadian factors. We take a conductance-based model approach to characterize how circadian rhythm modulates CA1 neural dynamics in the pathological state relative to a healthy state. In addition, our human studies have established a strong relationship between sleep disordered breathing and seizures. For example, in a cohort of children with absence epilepsy, sleep disordered breathing and attention problems were more frequent relative to age-matched normal children. Following treatment of their obstructive apnea, both seizures and inattention significantly improved relative to baseline. These results underscore the intricate relation between sleep, circadian rhythm, epilepsy and daytime behavior.

1. Stanley DA, Talathi SS, Carney PR. Chronotherapy in the treatment of epilepsy. Chrono Physiology and Therapy. Dove press. 109-123; 26 November 2014.

2. Stanley DA, Talathi SS, Parekh MB, et al. Phase shift in hippocampal circadian rhythm during the latent period of epileptic rats. J Neurophysiology. 2013 Sep; 110(5): 1070-86.

3. Talathi SS, Hwang DU, Ditto WL, et al. Circadian control of neural excitability in an animal model of temporal lobe epilepsy. Neurosci. Lett. 2009 May 15; 455(2): 145-9.

4. Becker DA, Fennell EB, Carney PR. Daytime behavior and sleep disturbance in childhood epilepsy. Epilepsy Behav. 2004: 5: 708-15.

5. Becker DA, Fennell, EB, Carney PR. Sleep disturbance in children with epilepsy. Epilepsy Behav. 2003: 4(6): 651-8.

For a full list of published work see:: https://scholar.google.com/scholar?q=paul+r+carney&hl=en

Teaching Statement

I have always enjoyed the vital role of education in medicine - education of students, patients, families, colleagues, and trainees. As a result, I have developed my career to function as an educator in multiple unique settings both domestically and globally.

A central goal of my teaching is the building of diverse teams across disciplines and mentoring of residents, clinical fellows, doctoral and master students, postdoctoral fellows, undergraduate students, and young faculty in neurology, neuroengineering and translational neuroscience. My main mission is to expand this area with strong translational-clinician-scientist-engineers, collaborating across disciplines, and translating basic science and concepts into therapy for patients.

My aspirations as a teacher and research advisor have always been to try to reach and engage students as individuals rather than a mass approach to all. Treating students as individuals and modifying our approach, rather than expecting students to fit an overly rigid teaching method has proven to be more effective. From my own experience, when a teacher personalizes and interacts with students in a more engaging manner, students tend to focus less on short term ‘what do I have to learn to pass the exam’ to a longer-term perspective of learning. Getting to know as many students as possible is a goal I have each semester, even when class sizes are large. Regarding clinical resident and fellow teaching, both bedside as well as tutorial are

https://scholar.google.com/scholar?q=paul+r+carney&hl=en


important as is honest and constructive feedback. I also plan to guide residents in training on the more relevant sources to seek new information.

An important step is to create student interest that promotes self -learning and ultimately the desire to master a subject at a deeper level rather than a simple regurgitation of presented information. I believe this promotes a piece-meal approach to learning that negatively impacts the student’s willingness to embrace life-long-learning. Rather, encouraging students to understand that learning is a continuing process and part of our everyday lives, promotes their willingness to think more creatively. Regarding resident physician and medical student education, my approach to teaching ranges from informal and formal lectures, bedside teaching, and mentorship. My goal is to provide lectures that suit the particular audience and attempt to fit a multitude of learning strategies for participants. Over the years, I have not only lectured at my institution, but also at international and national meetings and conferences.

I plan to lay the foundation for training grants such as a National Institutes of Health BRAIN Initiative Institutional Training grant (T32) and the Ruth L. Kirschstein Interdisciplinary Research Training Award (T90). I plan to evolve and enhance graduate education by expanding hands on engineering and clinical opportunities, tutorials, and increased feedback and involved career mentoring. I plan to develop and teach a 3-credit graduate level neural engineering/neuroscience clinical preceptorship course (fall, spring semesters). This course will emphasize the fundamentals of translational neural engineering and be aimed for neuroscience, engineering, medical students, as well as resident physicians and fellows.

I have extensive experience with graduate education as I was advisor for many doctoral and master level student, and a graduate school course and fellowship program director for the past 18 years at my previous institution. During my time as director, the program enhanced its national reputation and was able to increase its allotment of students and fellows per year. The curriculum was also redesigned and developed further with not only rotation specific goal enhancement but also a wide expansion of learning opportunities. Additionally, during my administrative duties at my previous institution and at present, I am an active mentor in research and grant support for learners and junior faculty. I also feel career transitions and development are important and can certainly be an aspect of teaching and mentoring.

As a teacher I plan to keep pace with developments in classroom technology through university seminars, and with published journals such as IEEE, Journal of Neural Engineering, Journal of Neuroscience, Annals of Neurology, Epilepsia, among others, as well as numerous websites devoted to education in general. I also value feedback from students and teachers, as well as standard class evaluation forms students fill out to evaluate their teachers. I pass out a similar form in the middle of the semester or clinical rotation to ask students and residents for their general comments and how the course or rotation might better suit their own professional and educational needs.

April, 2017

curriculum vitae paul r. carney, md - unc health care · williams & wilkins, inc.,...

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