Curriculum Vitae

AKIYAMA, Takahiko Date of birth: March 30, 1958 Gender: Male Business Address: Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo 171-8588, Japan Phone: +81-3-3986-0221(ext. 6489) Fax: +81-3-5992-1029 E-mail: takahiko.akiyama@gakushuin.ac.jp Employment: 04/1997- Professor, Department of Chemistry, Gakushuin University 04/1994-03/1997 Associate Professor, Department of Chemistry, Gakushuin University (04/1992-03/1993 Visiting Scholar, Department of Chemistry, Stanford University) 07/1988-03/1994 Assistant Professor, Department of Applied Chemistry, Ehime University 04/1985-06/1988 Research Chemist, Shionogi Research Laboratories, Shionogi & Co., Ltd. Education: 03/1985 Ph.D. The University of Tokyo 03/1982 M. Sc. Department of Chemistry, The University of Tokyo 02/1980 B.Sc. Department of Chemistry, The University of Tokyo Awards: 2016 Humboldt Research Award 2016 Arthur C. Cope Scholar Award 2012 JSPC (The Japanese Society for Process Chemistry) Award for Excellence 2012 Nagoya Silver Medal 2009 The Chemical Society of Japan Award for Creative Work for 2009. 2009 SSOCJ(The Society of Synthetic Organic Chemistry, Japan) Daiichi-Sankyo Award for Medicinal Organic Chemistry 2009. 1997 1997 Takeda Pharmaceutical Company Award in Synthetic Organic Chemistry, Japan. Research Interest Synthetic Organic Chemistry, Organocatalysis, Metal-mediated reactions

Associate Editor of Chemistry Letters (2006-2009) Associate Editor of Bulletin of the Chemical Society of Japan (2013-) Board Member of The Japanese Society for Process Chemistry (2006- ) Board Member of The Society of Synthetic Organic Chemistry, Japan (2012-2013) Board Member of The Japan Union of Chemical Society and Technology (2012) The Chair of the Kanto Branch of the Chemical Society of Japan (2014) Board Member of The Society of Synthetic Organic Chemistry, Japan (2015-2016) Board Member of The Japan Union of Chemical Society and Technology (2015)

Publication List

Takahiko AKIYAMA

1) Bond Switch with Participation of p-Bonded SIV from Isothiazole to Thiadiazole Ring System, K. Akiba, A. Noda, K. Ohkata, T. Akiyama, Y. Murata, and Y. Yamamoto, Heterocycles, 15, 1155-1158 (1981).

2) Stereospecific Alkylation of Sulfur-Stabilized Carbanion in Dithiabicyclo[3.1.0]hexane Systems, R. Okazaki, M. O-oka, T. Akiyama, and N. Inamoto, Heterocycles, 18, 241-244 (1982).

3) Preparation of Chiral Sulfones by Asymmetric Addition of Arenesulfonyl Carbanion to Acetone, T. Akiyama, M. Shimizu, and T. Mukaiyama, Chem. Lett., 1984, 611-614.

4) Stannous(II) Triflate Promoted Rearrangement of β-Keto Sulfoxides. Synthesis of 1,4-Diketones, M. Shimizu, T. Akiyama, and T. Mukaiyama, Chem. Lett., 1984, 1531-1534.

5) A Convenient Method for the Synthesis of α-Phenylthio-α,β-Unsaturated Ketone by Stannous Triflate Promoted Rearrangement of α-Sulfinyl Ketone, T. Akiyama, H. Iwakiri, M. Shimizu, and T. Mukaiyama, Chem. Lett., 1984, 1843-1846.

6) Highly Stereoselective Reactions of Carbanions of Dithiabicyclo[3.1.0]hexane Derivatives, R. Okazaki, M. O-oka, T. Akiyama, N. Inamoto, J. Niwa, and S. Kato, J. Am. Chem. Soc., 109, 5413-5419 (1987).

7) Preparation of Potentially Antitumor-Active Vinyl Polymers Having 5-Fluorouracil as a Component, S. Ozaki, J. Ohnishi, Y. Watanabe, T. Nohda, T. Nagase, T. Akiyama, N. Uehara, and A. Hoshi, Polym. J., 21, 955-958 (1989).

8) 5-Fluorouracil Derivatives. XVII. Synthesis and Antitumor Activity of 5'-O -Acyl-5-fluorouridines, S. Ozaki, T. Akiyama, Y. Ike, H. Mori, and A. Hoshi, Chem. Pharm. Bull., 37, 3405-3408 (1989).

9) p-Methoxybenzyl as a New N3-Imide Protecting Group of 5-Fluorouridine and its Application to the Synthesis of 5'-O-Acryloyl-5-Fluorouridine, T. Akiyama, M. Kumegawa, Y. Takesue, H. Nishimoto, and S. Ozaki, Chem. Lett., 1990, 339-342.

10) A Chiral Synthesis of D-myo-Inositol 1-Phosphate Starting from L-Quebrachitol, T. Akiyama, N. Takechi, and S. Ozaki, Tetrahedron Lett., 31, 1433-1434 (1990).

11) Preparation of Antitumor Active Vinyl Polymers Containing 5-Fluorouracil as a Component, S. Ozaki, J. Ohnishi, T. Akiyama, T. Nagase, N. Uehara, and A. Hoshi, Polym. J., 22, 689-695 (1990).

12) Anchimerically Assisted Demethylation of Methyl Ethers in Inositol Derivatives with an AlCl3-NaI System, T. Akiyama, N. Takechi, H. Shima, and S. Ozaki, Chem. Lett., 1990, 1881-1884.

13) The Selective Protection of Uridine with a p-Methoxybenzyl Chloride: A Synthesis of 2'-O -Methyluridine, T. Akiyama, H. Nishimoto, and S. Ozaki, Bull. Chem. Soc. Jpn., 63, 3356-3357 (1990).

14) 5-Fluorouracil Derivatives. XX. Synthesis and Antitumor Activity of 5'-O-Unsaturated Acyl 5-Fluorouridines, S. Ozaki, T. Akiyama, T. Morita, M. Kumegawa, T. Nagase, N. Uehara, and A. Hoshi, Chem. Pharm. Bull., 38, 3164-3166 (1990).

15) AlCl3-N,N-Dimethylaniline: A New Benzyl and Allyl Ether Cleavage Reagent, T. Akiyama, H. Hirofuji, and S. Ozaki, Tetrahedron Lett., 32, 1321-1324 (1991).

16) Diastereoselective Reduction of α-Keto Esters Bearing chiro–Inositol Derivatives as Chiral Auxiliaries, T. Akiyama, H. Nishimoto, and S. Ozaki, Tetrahedron Lett., 32, 1335-1338 (1991).

17) A Synthesis of 5'-O-Acryloyl-5-Fluorouridine by Use of p–Methoxybenzyl Group as an N3-Imide Protecting Group of 5-Fluorouridine, T. Akiyama, M. Kumegawa, Y. Takesue, H. Nishimoto, and S. Ozaki, Bull. Chem. Soc. Jpn., 64, 2266-2269 (1991).

18) A Concise Synthesis of (-)-Conduritol F from L-Quebrachitol via AlCl3-n-Bu4NI Mediated Demethylation, T. Akiyama, H. Shima, and S. Ozaki, Tetrahedron Lett., 32, 5593-5596 (1991).

19) Total Synthesis of Cyclophellitol from L-Quebrachitol, T. Akiyama, M. Ohnari, H. Shima, and S. Ozaki, Synlett, 1991, 831-832.

20) Chiral Synthesis of D-myo-Inositol 1-Phosphate Starting from L-Quebrachitol, T. Akiyama, N. Takechi, S. Ozaki, and K. Shiota, Bull. Chem. Soc. Jpn., 65, 366-372 (1992).

21) Diastereoselective Addition of Organometallics to α-Keto Esters Bearing chiro-Inositol Derivatives as Chiral Auxiliaries, T. Akiyama, H. Nishimoto, K. Ishikawa, and S. Ozaki, Chem. Lett., 1992, 447-450.

22) A New Efficient Method for Resolution of myo-Inositol Derivatives by Enzyme Catalyzed Regio- and Enantio-selective Esterification in Organic Solvent, L. Ling, Y. Watanabe, T. Akiyama, and S. Ozaki, Tetrahedron Lett., 33, 1911-1914 (1992).

23) Trimethylsilyl Chloride-Tin(II) Chloride-Anisole: A Novel Selective p-Methoxybenzyl Ether Cleavage Reagent, T. Akiyama, H. Shima, and S. Ozaki, Synlett, 1992, 415-416.

24) AlCl3-N,N-Dimethylaniline: A Novel Benzyl and Allyl Ether Cleavage Reagent, T. Akiyama, H. Hirofuji, and S. Ozaki, Bull. Chem. Soc. Jpn., 65, 1932-1938 (1992).

25) The Preparation of Optically Active ∆2-Isoxazolines via Addition of Nitrile Oxides to Chiral Acryloyl Esters Bearing Cyclitols as Auxiliaries, T. Akiyama, K. Okada, and S. Ozaki, Tetrahedron Lett., 33, 5763-5766 (1992).

26) Enzymatic Resolution of Racemic 1,2:4,5-Di-O-cyclohexylidene and 1,2:3,4-Di-O-cyclohexylidene-myo-Inositol, L. Ling, X. Li, Y. Watanabe, T. Akiyama, and S. Ozaki, Bioorganic & Medicinal Chemistry 1, 155-159 (1993).

27) Syntheses of (-)-Conduritol F, (+)-Conduritol B, and Cyclophellitol from L-Quebrachitol, T. Akiyama, H. Shima, M. Ohnari, T. Okazaki, and S. Ozaki, Bull. Chem. Soc. Jpn., 66, 3760-3767 (1993).

28) Stereodivergent Synthesis of Optically Active α-Hydroxy Acids via Diastereoselective Reduction of α−Keto Esters Derived from L-Quebrachitol, T. Akiyama, H. Nishimoto, T. Kuwata, and S. Ozaki, Bull. Chem. Soc. Jpn., 67, 180-188 (1994).

29) Stereoselective Construction of Tetrahydrofuran by Tin (IV) Chloride Promoted [3+2] Cycloaddition of Allylsilane to α-Keto Ester, T. Akiyama, K. Ishikawa, and S. Ozaki, Chem. Lett., 1994, 627-630.

30) Asymmetric Synthesis of Functionalized Tertiary Alcohols by Diastereoselective Aldol Reaction of Silyl Enol Ether and Ketene Silyl Acetal with α-Keto Esters Bearing an Optically Active Cyclitol as a Chiral Auxiliary, T. Akiyama, K. Ishikawa, and S. Ozaki, Synlett , 1994, 275-276.

31) Mild Deprotection of Methyl, Benzyl, Methoxymethyl, Methylthiomethyl, Methoxyethoxymethyl, and β-(Trimethylsilyl)ethoxymethyl Esters with AlCl3-N,N-Dimethylaniline, T. Akiyama, H. Hirofuji, A. Hirose, and S. Ozaki, Synth. Commun., 24, 2179-2185 (1994).

32) Asymmetric Synthesis of Tetrahydrofurans by Diastereoselective [3+2] Cycloaddition of Allylsilanes with α-Keto Esters Bearing an Optically Active Cyclitol as a Chiral Auxiliary, T. Akiyama, T. Yasusa, K. Ishikawa, and S. Ozaki, Tetrahedron Lett., 35, 8401-8404 (1994).

33) Stereoselective Construction of Oxetane by Titanium(IV) Chloride Promoted [2+2] Cycloaddition of Allylsilane to α-Keto Esters, T. Akiyama and M. Kirino, Chem. Lett., 1995, 723-724.

34) Stereodivergent Diels-Alder Reactions Employing Cyclitols as Chiral Auxiliaries, T. Akiyama, N. Horiguchi, T. Ida, and S. Ozaki, Chem. Lett., 1995, 975-976.

35) L-Quebrachitol as a New Chiral Building Block, T. Akiyama, J. Synth. Org. Chem. Jpn., 1996, 54, 84-93.

36) Preparation of Oxetanes by Zirconium(IV) Chloride Promoted Cycloaddition of Allylsilane to Aldehydes, T. Akiyama and M. Yamanaka, Synlett, 1996, 1095-1096.

37) The Scandium Trifluoromethanesulfonate-Catalyzed Chemoselective Allylation Reactions of Carbonyl Compounds with Tetraallylgermane in Aqueous Media, T. Akiyama and J. Iwai, Tetrahedron Lett., 38, 853-856 (1997).

38) Novel Lewis Acid Promoted Reactions of Allylsilane Bearing Bulky Silyl Substituents and Aldehydes, T. Akiyama, M. Nakano, J. Kanatani, and S. Ozaki, Chem. Lett., 1997, 385-386.

39) Base Promoted Preparation of Alkenylsilanols from Allylsilanes, T. Akiyama and S. Imazeki, Chem. Lett., 1997, 1077-1078.

40) Lewis Acid Mediated [3+2] Cycloaddition of Allylgermane: Stereoselective Synthesis of Germyl Substituted Tetrahydrofurans, T. Akiyama and M. Suzuki, Chem. Commun., 1997, 2357-2358.

41) Three-Component Synthesis of Homoallylamines by Scandium(III) Triflate-Mediated Allylation with Allylgermane: A Highly Imine Selective Allylation Reaction, T. Akiyama and J. Iwai, Synlett, 1998, 273-274.

42) Allyldiisopropylphenylsilane As a Synthetic Equivalent of 2-Hydroxy-1,3-Dipole–Stereoselective Synthesis of Cyclopentanols–, T. Akiyama, E. Hoshi, and S. Fujiyoshi, J. Chem. Soc., Perkin Trans 1, 1998, 2121-2122.

43) Stereoselective Synthesis of Cyclopentanols by Lewis Acid-Mediated [3+2] Annulation of Allyldiisopropylphenylsilane with α,β-Unsaturated Diesters, T. Akiyama, and M. Yamanaka, Tetrahedron Lett., 39, 7885-7888 (1998).

44) Stereoselective Synthesis of 2,3,5-Substituted Tetrahydrofurans by Silicon-Directed Cyclization of Allylsilanes Bearing a Hydroxy Moiety, T. Akiyama and Y. Ishida, Synlett, 1998, 1150-1152.

45) Lewis Acid Mediated Domino Allylation of Diallylsilane to α,β-Unsaturated Ketones, T. Akiyama, K. Asayama, and S. Fujiyoshi, J. Chem. Soc., Perkin Trans 1, 1998, 3655-3656.

46) Chiral Syntheses of 2,3,5-Trisubstituted Pyrrolidines by Silicon-Directed Cyclization of Allylsilanes Bearing a Sulfonamide Moiety, T. Akiyama, Y. Ishida, and H. Kagoshima, Tetrahedron Lett., 40, 4219-4222 (1999).

47) Scandium Trifluoromethanesulfonate-Catalyzed Chemoselective Allylation Reactions of Carbonyl Compounds with Tetraallylgermane in Aqueous Media, T. Akiyama, J. Iwai, and M. Sugano, Tetrahedron, 55, 7499-7508 (1999).

48) HBF4 Catalyzed Mannich-Type Reaction In Aqueous Media, T. Akiyama, J. Takaya, and H. Kagoshima, Synlett, 1999, 1045-1046.

49) One-pot Mannich-Type Reaction In Water: HBF4 Catalyzed Condensation of Aldehydes, Amines, and Silyl Enolates for the Synthesis of β-Amino Carbonyl Compounds, T. Akiyama, J. Takaya, and H. Kagoshima, Synlett, 1999, 1426-1428.

50) Chemoselective Activation of Aldimine in Preference to Aldehyde by the Combination of BF3•OEt2 and Water: Novel Catalyst for the Mannich-type Reaction, T. Akiyama, J. Takaya, and H. Kagoshima, Chem. Lett., 1999, 947-948.

51) Brønsted Acid-Catalyzed Aza Diels-Alder Reaction of Danishefsky's Diene with Aldimine Generated in situ from Aldehyde and Amine in Aqueous Media, T. Akiyama, J. Takaya, and H. Kagoshima, Tetrahedron Lett., 40, 7831-7834 (1999).

52) Chemoselective Allylation of Aldimine with Allyltriethylgermane By the Combined Use of BF3•OEt2 and CH3CO2H, T. Akiyama, J. Iwai, Y. Onuma, and H. Kagoshima, Chem. Commun., 1999, 2191-2192.

53) Lewis Acid Promoted [4+2] Annulation of Allylsilane and Allylgermane with Aldimine; Preparation of Tetrahydroquinolines, T. Akiyama, M. Suzuki, and H. Kagoshima, Heterocycles, 52, 529-532 (2000).

54) Development of Novel Synthetic Reactions Using Allylsilane, T. Akiyama, J. Synth. Org. Chem. Jpn., 58, 285-292 (2000).

55) Mannich-type Reaction with Trifluoromethylated N,O-Hemiacetal: Facile Preparation of β-Amino-β−Trifluoromethyl Carbonyl Compounds, J. Takaya, H. Kagoshima, and T. Akiyama, Org. Lett., 2, 1577-1579 (2000).

56) Novel [3+2] Cycloaddition Reaction of Alkenyl Fischer Carbene Complexes with Imines Leading to 3-Pyrroline Derivatives, H. Kagoshima and T. Akiyama, J. Am. Chem Soc., 122, 11741-11742 (2000).

57) Lewis Acid-Mediated [3+2] Cycloaddition of Allyltriisopropylsilane to N-Sulfonyl Aldimines, T. Akiyama, M. Sugano, and H. Kagoshima, Tetrahedron Lett., 42, 3889-3992 (2001).

58) Highly Stereo-Divergent Mannich-type Reaction Catalyzed by Brønsted Acid in Aqueous Media, T. Akiyama, J. Takaya, and H. Kagoshima, Tetrahedron Lett., 42, 4025-4028 (2001).

59) The Asymmetric [3+2] Cycloaddition Reaction of Chiral Alkenyl Fischer Carbene Complexes with Imines: Synthesis of Optically Pure 2,5-Disubstituted-3-Pyrrolidinones, H. Kagoshima, T. Okamura, and T. Akiyama, J. Am. Chem. Soc., 123, 7182-7183 (2001).

60) Catalytic, Enantioselective Propargyl- and Allenylation Reactions of α-Imino Esters, H. Kagoshima, T. Uzawa, and T. Akiyama, Chem. Lett., 2002, 288-289.

61) Tin(II) Chloride Mediated Allylation of Aldimines Generated in situ with Allylstannane in Water, T. Akiyama and Y. Onuma, J. Chem. Soc., Perkin Trans 1, 2002, 1157-1158.

62) Brønsted Acid Catalyzed Mannich-Type Reactions in Aqueous Media, T. Akiyama, J. Takaya, and H. Kagoshima, Adv. Synth. Catal. (Special Issue on Water), 344, 338-347 (2002).

63) Mannich-type Reaction Catalyzed by HBF4 in Water: Effect of the Loading of Surfactant, T. Akiyama, J. Itoh, and K. Fuchibe, Synlett, 2002, 1269-1272.

64) Novel Thermal Reaction of Fischer Carbene Complexes with Imines: Synthesis of β-Methoxy Allylic Amine Derivatives, K. Sangu, H. Kagoshima, K. Fuchibe, and T. Akiyama, Org. Lett., 4, 3967-3969 (2002).

65) Montmorillonite K10-Catalyzed Aza Diels-Alder Reaction of Danishefsky's Diene with Aldimines, Generated in situ from Aliphatic Aldehydes and Amine, in Aqueous Media, T. Akiyama, K. Matsuda, and K. Fuchibe, Synlett, 2002, 1898-1900.

66) Stereoselective Synthesis of CF3-Substituted Aziridines by Lewis Acid-Mediated Aziridination of Aldimines with Diazoacetates, T. Akiyama, S. Ogi, and K. Fuchibe, Tetrahedron Lett., 44, 4011-4013 (2003).

67) Synthesis of A Novel Crown Ether Derived from chiro-Inositol and Its Catalytic Activity On The Asymmetric Michael Addition, T. Akiyama, M. Hara, K. Fuchibe, S. Sakamoto, and K. Yamaguchi, Chem. Commun. 2003, 1734-1735.

68) Brønsted Acid-Mediated Synthesis of α-Amino Phosphonates under Solvent-Free Conditions, T. Akiyama, M. Sanada, and K. Fuchibe, Synlett, 2003, 1463-1464.

69) Cu(I)-Catalyzed Enantioselective [2+2] Cycloaddition of 1-Methoxyallenylsilane with α-Imino Ester: Chiral Synthesis of α,β-Unsaturated Acylsilanes, T. Akiyama, K. Daidouji, and K. Fuchibe, Org. Lett., 5, 3691-3693 (2003).

70) A Novel Approach to 2-Substituted Quinolines: Electrocyclization of Alkynyl Imines via Vinylidene Complexes, Sangu, K.; Fuchibe, K.; Akiyama, T. Org. Lett. 2004, 6 (3), 353-355.

71) Enantioselective Mannich–type Reaction Catalyzed by a Chiral Brønsted Acid, Akiyama, T.; Itoh, J.; Yokota, K.; Fuchibe, K. Angew. Chem. Int. Ed. 2004, 43 (12), 1566-1568.

72) Niobium-Catalyzed Reduction of Monofluoroarenes with LiAlH4, Fuchibe, K.; Akiyama, T. Synlett 2004, (7), 1282-1284.

73) Facile Method for the Preparation of Triarylsulfonium Bromides Using Grignard Reagents and Chlorotrimethylsilane as an Activator, Imazeki, S.; Sumino, M.; Fukasawa, K.; Ishihara, M.; Akiyama, T. Synthesis 2004, (10), 1648-1654.

74) Synthesis of Aryl-substituted Quinoline Derivatives via Brønsted Acid-Catalyzed [4+2] Aza Diels-Alder Reaction, Akiyama, T.; Nakashima, S.; Yokota, K.; Fuchibe, K. Chem. Lett. 2004, 33 (7), 922-923.

75) HCl-Catalyzed Stereoselective Mannich Reaction in H2O-SDS System, Akiyama, T.; Matsuda, K.; Fuchibe, K. Synlett 2005, (2) 322-324.

76) Cu(I)-Catalyzed Enantioselective [3+2] Cycloaddition Reaction of 1-Alkylallenylsilane with α-Imino Ester: Chiral Synthesis of Pyrroline Derivatives, Daidouji, K.; Fuchibe, K. Akiyama, T. Org. Lett. 2005, 7 (6), 1051-1053.

77) [3+2] Cycloaddition Reactions of Cyclopropylmethylsilanes and α-Keto Aldehydes: Trans- and Cis-Selective Formation of 2-Silylmethyltetrahydrofurans, Fuchibe, K.; Aoki, Y.; Akiyama, T. Chem. Lett. 2005, 33 (4), 538-539.

78) Mannich-type Reaction Promoted by an Ionic Liquid, Akiyama, T.; Suzuki, A.; Fuchibe, K. Synlett 2005, (6), 1024-1026.

79) Chiral Brønsted Acid Catalyzed Enantioselective Hydrophosphonylation of Imines: Asymmetric Synthesis of α-Amino Phosphonates, Akiyama, T.; Morita, H.; Itoh, J.; Fuchibe, K. Org. Lett. 2005, 7 (13), 2583-2585.

80) Montmorillonite K10 Catalyzed Nucleophilic Addition Reaction to Aldimines in Water, Akiyama, T.; Matsuda, K.; Fuchibe, K. Synthesis (Special Topic: Aqueous Chemistry), 2005, (15), 2606-2608.

81) Enantioselective Mannich-type Reaction Catalyzed by a Brønsted Acid Derived from TADDOL. Akiyama, T.; Saitoh, Y.; Morita, H.; Fuchibe, K. Adv. Synth. Catal. (Special Issue: Catalytic C-C Bond Formation) 2005, 347 (11-13), 1523-1526.

82) Enantioselective Three-Component Synthesis of 4-Arylated Dehydroprolines: [3+2] Annulation of Allenylstannane and α-Imino Ester, Fuchibe, K.; Hatemata, R.; Akiyama, T. Tetrahedron Lett., 2005, 46 (49) 8563-8566.

83) Brønsted Acid-catalyzed Addition and Cycloaddition Reaction with Imine: From Aqueous Reaction to Enantioselective Reactions, Akiyama, T.; Itoh, J.; Fuchibe, K. J. Synth. Org. Chem. Jpn. 2005, 63 (11), 1062-1068.

84) Enantioselective Aza Diels-Alder Reaction Catalyzed by a Chiral Brønsted Acid: Effect of the Additive on the Enantioselectivity, Akiyama, T.; Tamura, Y.; Itoh, J.; Morita, H.; Fuchibe, K. Synlett (Cluster: Brønsted Acid) 2006, (1), 141-143.

85) Stereoselective Synthesis of Tetrahydforuran by Diastereoselective [3+2] Cycloaddition Reaction of Chiral Allylsilane with α−Keto Ester, Akiyama, T.; Funaki, S.; Fuchibe, K. Heterocycles (Professor's Trost's Special Issue) 2006, 67 (1), 369-374.

86) Low Valent Niobium-Mediated Double Activation of C–F/C–H Bonds: Fluorene Synthesis from o-Arylated α,α,α-Trifluorotoluene Derivatives, Fuchibe, K.; Akiyama, T. J. Am. Chem. Soc. 2006, 128 (5), 1434-1435.

87) Synthesis of Pyrroles: Reaction of Chromium N–Alkylaminocarbene Complexes with α,β-Unsaturated Aldehydes, Fuchibe, K.; Ono, D.; Akiyama, T. Chem. Commun. 2006, (21), 2271-2273.

88) Recent Progress in the Chiral Brønsted Acid Catalysis, Akiyama, T.; Itoh, J.; Fuchibe, K. Adv. Synth. Catal. 2006, 348 (9), 999-1010.

89) Chiral Brønsted Acid Catalyzed Enantioselective Aza Diels-Alder Reaction of Brassard's Diene with Imines, Itoh, J.; Fuchibe, K.; Akiyama, T. Angew. Chem. Int. Ed. 2006, 45 (29), 4796-4798.

90) Chiral Brønsted Acid-Catalyzed Inverse Electron-demand Aza Diels-Alder Reaction, Akiyama, T.; Morita, H.; Fuchibe, K. J. Am Chem. Soc. 2006, 128 (40), 13070-13071.

91) One-Pot Synthesis of Chiral Dehydroproline Esters: [3+2]-Type Cycloaddition Reaction of Allenylstannane and α-Imino Ester, Fuchibe, K.; Hatemata, R.; Akiyama, T. Tetrahedron (Tetrahedron Young Investigator Award Issue for D. MacMillan) 2006, 62 (49), 11304-11310.

92) Mannich-type Reaction in Water in the Presence of a Surfactant, Itoh, J.; Fuchibe, K.; Akiyama, T. Synthesis 2006, (23), 4075-4080.

93) Low-valent Niobium-mediated Synthesis of Indenes: Intramolecular Coupling Reaction of CF3 Group with Alkene C–H Bond, Fuchibe, K.; Mitomi, K.; Akiyama, T. Chem. Lett. 2007, 36 (1), 24-25.

94) Synthesis of Nitrogen-containing Compounds Using Chromium Fischer Carbene Complexes, Kagoshima, H.; Fuchibe, K.; Akiyama, T. Chem. Rec. 2007, 7 (2), 104-114.

95) Low-valent Niobium-Catalyzed Reduction of α,α,α-Trifluorotoluenes, Fuchibe, K.; Ohshima, Y.; Mitomi, K.; Akiyama, T. Org. Lett. 2007, 9 (8), 1497-1499.

96) Carbocyclization Reaction of Active Methine Compounds with Allylsilane Moiety Mediated by AlCl3-n-Bu3N, Imazeki, S.; Kinoshita, R.; Akiyama, T. Bull. Chem. Soc. Jpn. 2007, 80 (5), 972-978.

97) Chiral Brønsted Acid Catalyzed Enantioselective Mannich-type Reaction, Yamanaka, M.; Itoh, J.; Fuchibe, K.; Akiyama, T. J. Am. Chem. Soc. 2007, 129 (21), 6756-6764.

98) Hydrodefluonations by Low-valent Niobium Catalyst, Fuchibe, K.; Ohshima, Y.; Mitomi, K.; Akiyama, T. J. Fluorine Chem. 2007, 128 (10), 1158-1167.

99) Stronger Brønsted Acid (Thematic Issue, Organocatalysis) Akiyama, T. Chem. Rev. 2007, 107 (12), 5744-5758.

100) C–C Coupling Reactions of Superstrong CF3 Groups with C(sp2)-H Bonds: Reactivity and Synthetic Utility of Zero-valent Niobium Catalyst, Fuchibe, K.; Mitomi, K.; Suzuki, R.; Akiyama, T. Chem. Asian J. 2008, 3 (2), 261-271.

101) Vinylogous Mannich-type Reaction Catalyzed by an Iodine-Substituted Chiral Phosphoric Acid, Akiyama, T.; Honma, Y.; Itoh, J.; Fuchibe, K. Adv. Synth. Catal. 2008, 350 (3), 399-402.

102) Preparation of β-Amino Esters by Chiral Brønsted Acid-Catalyzed Mannich-type Reaction, Itoh, J.; Fuchibe, K.; Akiyama, T. Synthesis (PSP article, invited) 2008, (8), 1319-1322.

103) Chiral Phosphoric Acid Catalyzed Enantioselective Friedel-Crafts Alkylation of Indoles with Nitroalkenes-Cooperative Effect of MS 3Å, Itoh, J.; Fuchibe, K.; Akiyama, T. Angew. Chem. Int. Ed. 2008, 47 (21), 4016-4018.

104) Mechanistic Study on the Base-Promoted Synthesis of Alkenylsilanols from Allylsilanes, Imazeki, S.; Sugawara, H.; Sano, A.; Akiyama, T. Bull. Chem. Soc. Jpn. 2008, 81 (5), 623-629.

105) Catalytic Activation of Carbon-fluorine Bonds by Low-valent Niobium Species, Fuchibe, K.; Akiyama, T. J. Synth. Org. Chem. Jpn. 2009, 67 (3), 208-218.

106) Enantioselective Robinson-type Annulation Reaction Catalyzed by Chiral Phosphoric Acid, Akiyama, T.; Katoh, T.; Mori, K. Angew. Chem. Int. Ed. 2009, 48 (23), 4226-4228.

107) Enantioselective Aza Darzens Reaction Catalyzed by a Chiral Phosphoric Acid, Akiyama, T.; Suzuki, T.; Mori, K. Org. Lett. 2009, 11 (11), 2445-2447.

108) Concise Construction of Quinazolines via Brønsted Acid Induced C-H Activation: Further Extensions of the "tert-Amino Effect", Mori, K.; Ohshima, Y.; Ehara, K.; Akiyama, T. Chem. Lett. 2009, 38 (6), 524-525.

109) Dual Functionalization of Allene: Facile Construction of Heteropolycycles Catalyzed by Brønsted Acid, Mori, K.; Sueoka, S.; Akiyama, T. Chem. Lett. 2009, 38 (6), 628-629.

110) Enantioselective Mannich-type Reaction Catalyzed by a Chiral Phosphoric Acid Bearing (S)-Biphenol Backbone, Akiyama, T.; Katoh, T.; Mori, K.; Kanno, K. Synlett (Cluster: Bifunctional Catalyst, invited), 2009 (10), 1664-1666.

111) Chiral Brønsted Acid Catalyzed Hydrophosphonylation of Aldimines: DFT Study on the Effect of Substituents on the Phosphoric Acid, Akiyama, T.; Morita, H.; Bachu, P.; Mori, K.; Yamanaka, M.; Hirata, T. Tetrahedron (Tetrahedron Young Investigator Award Issue for Michael J. Krische, invited), 2009, 65 (26), 4950-4956.

112) Brønsted Acid-catalyzed Nazarov Cyclization of Pyrrole Derivatives by Microwave Acceleration, Bachu, P.; Akiyama, T. Bioorg. Med. Chem. Lett. (Tetrahedron Young Investigator Award Issue for Carlos F. Barbas, invited), 2009, 19 (14), 3764-3766.

113) Benzothiazoline: Highly Efficient Reducing Agent for the Enantioselective Organocatalytic Transfer Hydrogenation of Ketimines, Zhu, C.; Akiyama, T. Org. Lett. 2009, 11 (18), 4180-4183.

114) Expedient Synthesis of N-Fused Indoles: C-F Activation and C-H Insertion Approach, Fuchibe, K.; Kaneko, T.; Mori, K.; Akiyama, T. Angew. Chem. Int. Ed. (VIP article) 2009, 48 (43), 8070-8073.

115) Chiral Phosphoric Acid Catalyzed Desymmetrization of meso-1,3-Diones: Asymmetric Synthesis of Chiral Cyclohexenones, Mori, K.; Katoh, T.; Suzuki, T.; Noji, T.; Yamanaka, M.; Akiyama, T. Angew. Chem. Int. Ed. 2009, 48 (51), 9652-9654.

116) Enantioselective Friedel-Crafts Alkylation of Indoles, Pyrroles, and Furans with 3,3,3-Trifluoropyruvate Catalyzed by Chiral Phosphoric Acid, Kashikura, W.; Itoh, J.; Mori, K.; Akiyama, T. Chem. Asian J. 2010, 5 (3), 470-472.

117) Expeditious Synthesis of Benzopyrans via Lewis Acid Catalyzed C-H Functionalization: Remarkable Enhancement of Reactivity by Ortho-Substituent, Mori, K.; Kawasaki, T.; Sueoka, S.; Akiyama, T. Org. Lett. 2010, 12 (8), 1732-1735.

118) Enantioselective Friedel-Crafts Alkylation Reaction of Indoles with Unsaturated Acyl Phosphonates Catalyzed by a Chiral Phosphoric Acid, Bachu, P.; Akiyama, T. Chem. Commun. 2010, 46 (23), 4112-4114.

119) Synthesis and Properties of Phosphoroselenoic Acids, and their Salts Bearing Binaphthyl Groups, Murai, T.; Monzaki, M.; Katoh, T.; Suzuki, T.; Akiyama, T. Phosphorus, Sulfur, Silicon Relat. Elem. 2010, 185 (5-6) 964-973.

120) Niobium-catalyzed Activation of CF3 Group on Alkene: Synthesis of Substituted Indenes, Fuchibe, K.; Atobe, K.; Fujita, Y.; Mori, K.; Akiyama, T. Chem. Lett. 2010, 39 (8), 867-869.

121) Benzothiazoline: Highly Efficient Reducing Agent for the Enantioselective Organocatalytic Transfer Hydrogenation of α-Imino Esters, Zhu, C.; Akiyama, T. Adv. Synth. Catal. 2010, 352 (11+12), 1846-1850.

122) A One-pot Tandem Approach of Synthesis of Benzothiazoles from Benzyl Halides, Zhu, C.; Akiyama, T. Synlett 2010, (16) 2457-2460.

123) Chiral Brønsted Acid-Catalyzed Asymmetric Friedel-Crafts Alkylation of Indoles with α,β-Unsaturated Ketones: Short Access to Optically Active 2- and 3-Substituted Indole Derivatives, Sakamoto, T.; Itoh, J.; Mori, K.; Akiyama, T. Org. Biomol. Chem. 2010, 8 (23), 5448-5454.

124) Expeditious Construction of a Carbobicyclic Skeleton via a sp3-C–H Functionalization: Hydride Shift from an Aliphatic Tertiary Position in an Internal Redox Process, Mori, K.; Sueoka, S.; Akiyama, T. J. Am. Chem. Soc. 2011, 133 (8), 2424-2426.

125) Chiral Phosphoric Acid Catalyzed Enantioselective Synthesis of β-Amino-α,α−difluoro Carbonyl Compounds, Kashikura, W.; Mori, K.; Akiyama, T. Org. Lett. 2011, 13 (7), 1860-1863.

126) Selective Activation of Enantiotopic C(sp3)-Hydrogen by Means of a Chiral Phosphoric Acid: Asymmetric Synthesis of Chiral Tetrahydroquinoline Derivatives, Mori, K.; Ehara, K.; Kurihara, K.; Akiyama, T. J. Am. Chem. Soc. 2011, 133 (16), 6166-6169.

127) Brønsted Acid Catalyzed Reductive Amination with Benzothiazoline as a Highly Efficient Hydrogen Donor, Zhu, C.; Akiyama, T. Synlett (Cluster: Brønsted Acid, invited) 2011, (9) 1251-1254.

128) Chiral Phosphoric Acid Catalyzed Transfer Hydrogenation: A Facile Synthetic Access to Highly Optically Active Trifluoromethylated Amines, Henseler, A.; Kato, M.; Mori, K.; Akiyama, T. Angew. Chem. Int. Ed. 2011, 50 (35), 8180-8183.

129) Development of Chiral Brønsted Acid and its Application to Asymmetric Synthesis, T. Akiyama, J. Synth. Org. Chem. Jpn., 2011, 69 (8), 913-925.

130) Rapid Access to 3-Aryltetraline Skeleton via C(sp3)–H Bond Functionalization: Investigation on the Substituent Effect of Aromatic Ring Adjacent to C–H Bond in Hydride Shift/Cyclization Sequence, Mori, K.; Sueoka, S.; Akiyama, T. Chem. Lett. 2011, 40 (12), 1386-1388.

131) Carboxyl-Tailed Benzothiazoline: A Readily Removable Hydrogen Donor for the Transfer Hydrogenation of Imines, Zhu, C.; Akiyama, T. Tetrahedron Lett. 2012, 53 (4), 416-418.

132) Concise Route to 3-Arylisoquinoline Skeleton by Lewis Acid Catalyzed C(sp3)–H Bond Functionalization and Its Application to Formal Synthesis of (±)-Tetrahydropalmatine, Mori, K.; Kawasaki, T.; Akiyama, T. Org. Lett. 2012, 14 (6), 1436-1439.

133) Enantioselective Organocatalytic Reductive Amination of Aliphatic Ketones by Benzothiazoline as Hydrogen Donor, Saito, K.; Akiyama, T. Chem. Commun. 2012, 48 (38), 4573-4575.

134) Phosphoric Acid Catalyzed Enantioselective Transfer Deuteration of Ketimines by Use of Benzothiazoline as a Deuterium Donor: Synthesis of Optically Active Deuterated Amines, Sakamoto, T.; Mori, K.; Akiyama, T. Org. Lett. 2012, 14 (13) , 3312-3315.

135) Kinetic Resolution in Chiral Brønsted Acid Catalyzed Aldol Reaction: Enantioselective Robinson-type Annulation Reaction, Yamanaka, M.; Hoshino, M.; Katoh, T.; Mori, K.; Akiyama, T. Eur. J. Org. Chem. 2012, (24), 4508-4514.

136) Enantioselective Synthesis of Multisubstituted Biaryl Skeleton by Chiral Phosphoric Acid Catalyzed Desymmetrization/Kinetic Resolution Sequence, Mori, K.; Ichikawa, Y.; Kobayashi, M.; Shibata, Y.; Yamanaka, M.; Akiyama, T. J. Am. Chem. Soc. 2013, 135 (10), 3964-3970.

137) Molecular Iodine Catalyzed Transfer Hydrogenation: Reduction of Aldimines, Ketimines, and α-Imino esters, Bachu, P.; Zhu, C.; Akiyama, T. Tetrahedron Lett. 2013, 54 (30), 3977-3981.

138) Hydrodefluorinations of Trifluorotoluenes by LiAlH4 and TiCl4. Akiyama, T.; Atobe, K.; Shibata, M.; Mori, K. J. Fluorine Chem. for special issue of Valencia Fluorine Days. 2013, 152, 81-83.

139) Chiral Phosphoric Acid Catalyzed Oxidative Kinetic Resolution of Indolines Based on Transfer Hydrogenation to Imines, Saito, K.; Shibata, Y.; Yamanaka, M.; Akiyama, T. J. Am. Chem. Soc. 2013, 135 (32), 11740-11743.

140) Prediction of Suitable Catalyst by 1H NMR: Asymmetric Synthesis of Multisubstituted Biaryls by Chiral Phosphoric Acid Catalyzed Asymmetric Bromination, Mori, K.; Ichikawa, Y.; Kobayashi, M.; Shibata, Y.; Yamanaka, M.; Akiyama, T. Chem. Sci. 2013, 4 (11), 4235-4239.

141) Enantioselective Transfer Hydrogenation of Difluoromethyl Ketimines Using Benzothiazoline as a Hydrogen Donor in Combination with Chiral Phosphoric Acid, Sakamoto, T.; Horiguchi, K.; Saito, K.; Mori, K.; Akiyama, T. Asian J. Org. Chem. 2013, 2 (11), 943-946.

142) Chiral Copper(II) Phosphate Catalyzed Enantioselective Synthesis of Isochromene Derivatives by Sequential Intramolecular Cyclization and Asymmetric Transfer Hydrogenation of o-Alkynylacetophenones, Saito, K.; Kajiwara, Y.; Akiyama, T. Angew. Chem. Int. Ed. 2013, 52(50), 13284–13288.

143) Enantioselective Fluorination of β-Ketoesters Catalyzed by Chiral Sodium Phosphate: Remarkable Enhancement of Reactivity by Simultaneous Utilization of Metal Enolate and Metal Phosphate, Mori, K.; Miyake, A.; Akiyama, T. Chem. Lett. 2014, 43 (1), 137-139.

144) Expeditious Construction of 1-Aminoindane Derivatives achieved by [1,4]-Hydride Shift Mediated C(sp3)-H Bond Functionalization, Mori, K.; Kurihara, K.; Akiyama, T. Chem. Commun. 2014, 50 (28), 3729-2731.

144) Double C(sp3)-H Bond Functionalization Mediated by Sequential Hydride Shift/Cyclization Process: Diastereoselective Construction of Polyheterocycles, Mori, K.; Kurihara, K.; Yabe, S.; Yamanaka, M.; Akiyama, T. J. Am. Chem. Soc. 2014, 136 (10), 3744-3747.

145) Stereoselective Construction of All Carbon Quaternary Center by Means of Chiral Phosphoric Acid: Highly Enantioselective Friedel-Crafts Reaction of Indoles with β,β-Disubstituted Nitoroalkenes, Mori, K.; Wakazawa, M.; Akiyama, T. Chem. Sci. 2014, 5 (5), 1799-1803.

146) Phosphoric Acid Bridged Cobalt bis(Dicarbollide) Ion as Highly Efficient Reducing Agent for the Organocatalytic Hydrogenation of Ketimines, Akiyama, T.; Saito, K.; Janczk, S.; Lesnikowski, Z. J. Synlett 2014, 25 (6), 795-798.

147) Chiral Phosphoric Acid Catalyzed Transfer Hydrogenation of Ketimine Derivatives; Remarkable Difference in Enantioselectivity Depending on Hydrogen Donors, Saito, K.; Horiguchi, K.; Shibata, Y.; Yamanaka, M.; Akiyama, T. Chem. Eur. J. 2014, 20 (25), 7616-7620.

148) Asymmetric Transfer Hydrogenation of Ketimines by Indoline as Recyclable Hydrogen Donor, Saito, K.; Miyashita, H.; Akiyama, T. Org. Lett. 2014, 16 (20), 5312-5315.

149) Enantioselective Synthesis of Chiral Biaryl Chlorides/Iodides by a Chiral Phosphoric Acid Catalyzed Sequential Halogenation Strategy, Mori, K.; Kobayashi, M.; Itakura, T.; Akiyama, T. Adv. Synth. Catal. 2015, 357 (1), 35-40.

150) Benzothiazoline: Versatile Hydrogen Donor for Organocatalytic Transfer Hydrogenation, Zhu, C.; Saito, K.; Yamanaka, M.; Akiyama, T. Acc. Chem. Res. 2015, 47 (2), 388-398.

151) γ-Silylboronates in the Chiral Brønsted Acid-catalyzed Allylboration of Aldehydes, Bario, P.; Rodríguez, E.; Saito, K.; Fuestro, S.; Akiyama, T. Chem. Commun. 2015, 51 (25), 5246-5249.

152) Synthesis of 1-Trifluoromethyl-3-Aryltetrahydroisoquinolines by Brønsted Acid Catalyzed C(sp3)–H Bond Functionalization, Mori, K.; Umehara, N.; Akiyama, T. Adv. Synth. Catal. 2015, 357 (5), 901-906.

153) Synthesis of 1-Trifluoromethyl-3-Aryltetrahydroisoquinolines by Brønsted Acid Catalyzed C(sp3)–H Bond Functionalization, Mori, K.; Umehara, N.; Akiyama, T. Adv. Synth. Catal. 2015, 357 (5), 901-906.

154) Chiral Phosphoric Acid Catalyzed Asymmetric Synthesis of 2-Substituted 2,3-Dihydro-4-Quinolones by Protecting Group Free Approach, Saito, K.; Moriya, Y.; Akiyama, T. Org. Lett. 2015, 17 (13), 3202-3205.

155) B(C6F5)3-Catalyzed Hydrodesulfurization Using Hydrosilanes–Metal-Free Reduction of Sulfides, Saito, K.; Kondo, K.; Akiyama, T. Org. Lett. 2015, 17 (13), 3366-3369.

156) Stronger Brønsted Acids; Recent Progress, Akiyama, T.; Mori, K. Chem. Rev. 2015, 115 (17), 9277-9306.

157) Enantioselective Synthesis of Fused Heterocycles with Contiguous Stereogenic Centers by Chiral Phosphoric Acid Catalyzed Symmetry Breaking, Mori, K.; Miyake, A.; Akiyama, Chem. Commun. 2015, 51 (89), 16107 - 16110.

158) Chiral Phosphoric Acid Catalyzed Oxidative Kinetic Resolution of Cyclic Secondary Amine Derivatives including Tetrahydroquinolines by Hydrogen Transfer to Imines, Saito, K.; Miyashita, H.; Akiyama, T. Chem. Commun. 2015, 51 (93), 16648-16651.

159) Transformation of Trifluorotoluenes Triggered by Titanium Chloride(IV) Catalyzed Hydrodefluorination Using Hydrosilanes, Yamada, T.; Saito, K.; Akiyama, T. Adv. Synth. Catal. 2016，358 (1), 62-22.

160) Why Benzothiazoline Cannot Be as Effective as Hantzsch Ester as a Hydrogen Donor in Chiral Phosphoric Acid-Catalyzed Asymmetric Reductive Amination of Ketones? Kim, K.-H.; Akiyama, T., Cheon, C.-H. Chem. Asian J. 2016, 11(2), 274-279.

161) Chiral Phosphoric Acid Catalyzed Kinetic Resolution of Indolines Based on Self-Redox Reaction, Saito, K.; Akiyama, T. Angew. Chem. Int. Ed. 2016, 55, xxxx. Early View. DOI: 10.1002/anie.201510692.