Curriculum Vitae University of Alabama at Birmingham

School of Medicine faculty Date: October 2019 RANK/TITLE Tenured Full Professor Department: Department of Pathology, Division of Molecular and Cellular Pathology Business address: 901 19th street South, BMRII Room 534, Birmingham, AL35294 Phone: Tel: 205 996-5153 Fax: Fax: 205 934-7447 Email: jianhuazhang@uabmc.edu EDUCATION Year Degree Institution 1980-1985 B.Sc. Department of Biology, University of Science and Technology of China, China 1985-1991 Ph.D Department of Biochemistry, University of Texas Southwestern Medical

Center at Dallas, TX, USA, with Professor Joseph Sambrook, FRS, FAA POSTDOCTORAL TRAINING Year Institution 1991-1995 Whitehead Institute for Biomedical Research with Professor Richard Young ACADEMIC APPOINTMENTS (IN REVERSE CHRONOLOGICAL ORDER) 2019-pesent 2012-2019

Tenured Full Professor, Department of Pathology, University of Alabama at Birmingham Tenured Associate Professor, Department of Pathology, University of Alabama at Birmingham

2011-2012 Associate Professor, Department of Pathology, University of Alabama at Birmingham

2006-present Faculty (secondary appointment), Department of Cell Biology, the department changed to Department of Cell, Developmental and Integrative Biology (CDIB) in 2012, UAB

2005-present Faculty (secondary appointment), Department of Neurobiology, UAB 2005-2011 Tenure Track Assistant Professor, Department of Pathology, University of

Alabama at Birmingham 1996-2005 Research Assistant Professor, Department of Cell Biology, Neurobiology and

Anatomy, University of Cincinnati College of Medicine Secondary APPOINTMENTS 2019-present Faculty mentor on Hypertension T32, UAB 2017-present Faculty member, Comprehensive Cancer Center (CCC), UAB 2016-present Faculty member, Nutrition Obesity Research Center (NORC), UAB 2016-present 2010-present

Faculty member, Alzheimer’s Disease Center (ADC), UAB Faculty member, Center for Free Radical Biology (CFRB), UAB

2008-present Faculty member, Alzheimer’s Disease Research Center (ADRC), UAB 2007-present Faculty member, Center for Neurodegeneration and Experimental Therapeutics

(CNET), UAB 2006-present Faculty member, Center for Aging (CFA), UAB

2006-present Associate Scientist, Civitan International Research Center (CIRC) 2006-present Faculty member, Comprehensive Neuroscience Center (CNC) UAB Graduate Program Affiliations: 2005-present Faculty, Integrative Biological Sciences (IBS), University of Alabama at

Birmingham 2005-present Faculty, Molecular Pathology (MCP), University of Alabama at Birmingham 2005-present Faculty, Neurobiology (NB), University of Alabama at Birmingham 2005-present Faculty, Cell and Molecular Biology (CMB), University of Alabama at Birmingham 2006-present Faculty, Neuroscience (NS), University of Alabama at Birmingham 2006-present Faculty, Interdisciplinary Genetics Graduate Program (IGGP), University of

Alabama at Birmingham 2008-present Faculty, Medical scientist training program (MSTP), University of Alabama at

Birmingham University of Cincinnati Graduate Program Affiliations: 1997-2005 Faculty, Interdisciplinary Ph.D. Program in Molecular Cell Biology, University of

Cincinnati College of Medicine 1998-2005 Faculty, Interdisciplinary Ph.D. Program in Neuroscience, University of Cincinnati

College of Medicine 1998-2005 Faculty, Medical Science Scholar (MD/PhD) Program, University of Cincinnati

College of Medicine AWARDS/HONORS 1985-1991 CUSBEA (China United States Biochemistry Examination Application) Exchange

Student. The program started in 1982 and ended in 1989 to recruit between 40 to 60 students from China to the US Universities each year.

1990 Sigma Xi Award. The University of Texas Southwestern Medical Center at Dallas. Student presentation award for that year.

2011 Young Investigator Award. Society for Free Radical Biology and Medicine conference Brazil.

2013 Selected as the recipient of the most cited paper award from Molecular Brain 2016 UAB Nutrition & Obesity Center “Creativity is a Decision” award PROFESSIONAL SOCIETIES 2001-2006 American Association for Cancer Research 1996-2013 Society for Neuroscience 2012-2013 American Physiology Society 2005-present Chinese Biologic Investigator Society 2006-present Society of Chinese Bioscientists in America (2006-2016 president for Alabama

Chapter) 2006-present Birmingham Chinese Professor Association (president from 2006-2016) 2010-present Association for Neurons and Diseases 2010-present Society for Redox Biology and Medicine (council member 2012 to present, VP

Finance 2018 to present) COUNCILS AND COMMITTEES: Ad hoc grant reviews:

DOD: 2006-2012 Department of Defense CET-1 (Cancer Experimental Therapeutics-1) NSF: 2008 NSF AHA: 2009-2012 American Heart Association, Region 2 Brain Study Sections VA: 2010 VA merit award NURC 2016 VA Aging and neurodegenerative disease, RR&D MERIT REVIEW AWARD USA: 1998 Ohio Cancer Research Associates, USA 2004 Philip Morris External Research Program 2004-2005 University Research Council, University of Cincinnati 2010 Louisiana Board of Regents’ Research 2012 Review for Pennsylvania Department of Health 2018 Review for Pennsylvania Department of Health 2018 CCTS Pilot Program 2019 CCTS Pilot Program NIH: 2012 NIH Brain Disorders and Related Neurosciences Fellowship Study Section (F01)

study sections 2014 NIH Director’s Transformative Research Award initiative (ZRG1 BCMB-A 51) 2014 NIH Special Emphasis Panel (9/2014) 2014 NIH CDIN study section 2015 NIH CDIN study section 2015 NIH “Support of Competitive Research (SCORE)” applications 2016 NHLBI PPG 2016 NIH NOMD study section 2017 NIH MDCN-E ( 2017 NCI ZCA1 SRB-K Clinical and Translational R21 & Omnibus R03 2017-present NIA ZRG1 BDCN Aging and Alzheimer’s disease 2018 ZAG1 ZIJ-P (A1) Role of peripheral proteostasis on brain aging and AD 2018 ZAG1 ZIJ-U (A1) NIA RFA-AG-18-023 ‘Pathogenesis of Age-Related HIV

Neurodegeneration” 2018 ZAG1 ZIJ-8 (A1) RFA AG18-018 “Development of Valid Reliable Markers of

Aging-Related Biologic Mechanisms for Human Studies” 2018 ZNS1 SRB-J (21) LBD CWOW and ADRD Pathways and Targets 2019 NIH NOMD study section 2019 P01 PD and LBD International foundations: 2004-2005 National Natural Sciences Foundation of China (NNSFC), PRC 2009-present Alzheimer’s Association (application several cycles each year) 2010 The Wellcome Trust-DBT India Alliance 2012 Review for CARIPARO Foundation

2012 Review for European Research Council (ERC) IDEA program 2013-present Parkinson's UK (applications each year) 2013 The Fund for Scientific Research (F.R.S.-FNRS), Brussels, Belgium 2015 The Netherlands Organisation for Scientific Research (NWO) 2015 European Research Council (ERC) 2015 ‘Sino-Dutch Joint Research Projects: Stem Cell Research’ 2015 The Fund for Scientific Research (F.R.S.-FNRS), Brussels, Belgium 2015 National Science Centre, Poland 2015 Action Medical Research for children, UK 2015 The French National Research Agency 2015 Alzheimer's Society, UK 2016 The Motor Neuron Disease Association UK 2016 The French National Research Agency 2016 UK Biotechnology and Biological Sciences Research Council (BBSRC) Institute

Strategic Programme Grant (ISPG) applications 2016 BioTechMed-Graz applications 2016 MRC, UK 2017 MRC, UK 2018 Diabetes UK 2018 Vici programme NWO, The Netherlands Society for Redox Biology and Medicine: 2010-present Mentor for graduate students/postdocs in the US and South America, Society for

Free Radical Biology and Medicine 2011 Women in Science committee, Society for Free Radical Biology and Medicine 2011 Awards committee, Society for Free Radical Biology and Medicine 2011-present Review committee for abstract, Society for Free Radical Biology and Medicine 2012 Finance and Investments subcommittee, Society for Free Radical Biology and

Medicine 2012 External Marketing Committee, Society for Free Radical Biology and Medicine 2012-2017 Internal Marketing Committee Chair, Society for Free Radical Biology and

Medicine 2012-present Review committee for Young Investigator Award (SFRBM) 2012-present Council, Society for Free Radical Biology and Medicine 2017-2018 Free Radical School Co-Chair, 2018-present VP Finance Meeting Chair and organizer: 2002 The eighth Cincinnati Neurofest “Neurodevelopment and brain function” 2004 Ohio Miami Valley Chapter of the Society for Neuroscience Activity Committee 2011 Co-Chair of plenary Session in Society of Free Radical Biology and Medicine

annual conference, “Oxidative Stress in Neurodegenerative Diseases” 2011 2011 Co-Chair, the 17th International Biophysics Congress (17th IBC) (IUPAB),

Satellite Meeting 1, The 4th International Symposium on Natural Antioxidants - Molecular Mechanisms and Health Effects, Section II, Beijing, 2011

2012 Co-Chair, “Oxidative Stress and Autophagy in Health and Disease” Society for Free Radical Research International (SFRRI), London, 2012

2013 Co-Chair of symposium “Neuroprotection” in NeuroTalk 2013, Xi’An, May 2013 2014 Society for Free Radical Biology and Medicine Annual Meeting Program

Committee

2014 Co-Chair of symposium “Oxidative stress and autophagy in Society for Free Radical Research International (SFRRI), Japan, 2014

2014 Co-Chair in Session 1: Free radical: oxidative and redox regulation. The 2nd International Chinese Symposium on Free Radical Research. November 2014, Hong Kong

2016 SfRBM regional meeting moderator 2017-2018 Free Radical School Co-Chair, Society for Free Radical Biology and Medicine 2018-2020 Scientific Program Committee for Society for Free Radical Research

International (SFRRI 2020) 2019 Co-Chair of plenary session in SfRBM: “Oxy-Inflammation, Redox Signaling and

Autophagy: Crosstalk in Health and Disease.” UNIVERSITY ACTIVITIES: Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati: 1999-2002 Cell and Molecular Biology Graduate Program Recruitment Committee 1999-2002 Cell and Molecular Biology Graduate Program Annual Retreat Committee 2003-2005 Cell and Molecular Biology Graduate Program First Year Advisor 1998-2005 Annual Graduate Student Research Forum Judge 2003-2005 Annual Postdoc Research Forum Poster Judging, 2002 Organizing committee member, the eighth Cincinnati Neurofest

“Neurodevelopment and Brain Function” 2005 Judge, Ohio District Science Day/2005 Science & Engineering Expo (SEE) University of Alabama at Birmingham: Mentoring/education: 2005-present Judge, Medical Student/Post Doc/Graduate Research Days/rotations,

CCC/CNC/CNET retreat, Neural conference, UAB 2006-present Recruitment interviewer, IBS, CMB/CMDB, NS, MCP/PBMM, SPIN, PREP,

GGS, MSTP 2012 Genetics and Genomic Sciences Graduate Program Admission Committee 2018-present Pathology Trainee Research Day committee 2018-present Cancer graduate program curriculum committee 2018-present PBMM recruitment committee 2018-present Education Chair, The American Medical Women’s Association Chapter at

UAB 2019- Postdoc recruitment focus group, UAB 2015-present Contributing to training grant applications:

• UAB Training Program In Neuroscience T32NS095775-01, • T32 training grant for aging research • TRAINING PROGRAM IN THE NEUROBIOLOGY OF COGNITION AND

COGNITIVE DISORDERS NIH/NINDS T32NS061788-09, • UAB NEUROSCIENCE ROADMAP SCHOLARS PROGRAM NIH/NINDS

R25RNS089463A-03, • T32 training grant for translational research • Education Core for the ADRC P30 • T32 Mechanisms of hypertension and cardiovascular diseases

Diversity: 2008-2010 UAB Women’s Scholarship Reviewing Committee 2008 Nominating Committee to Select Representatives to the UAB Commission on

the Status of Women 2010 Reviewer for Faculty nominee packets for the President's Diversity Award 2011 Selected Representative to the UAB Commission on the Status of Women Faculty search: 2009 Search Committee for Neuropathology Faculty Position, UAB 2012 Search Committee for Neuropathology Faculty Position 2014 Faculty Search Committee for MCP/microbiology and immunology 2017-present Neuropathology Division Director Search Committee, Dept Pathology, UAB 2018 MCP faculty recruitment committee 2019 Interviewing faculty candidate for Depts of Pathology, Cell biology, and

Microbiology, UAB Research centers, seminars and symposiums: 2010-2011 Co-Chair Neurodegeneration and Repair subgroup UAB SOM Strategic Plan

in the Neuroscience Steering Committee, 2010 UAB SOM Strategic Plan committee in the Diabetes Complication Subgroup

for the Diabetes, Obesity & Metabolism Research Priority Theme 2011-present Pritchett lecturer selection committee 2012 The Organizing Committee for Symposium on Neurodegeneration 2012 Reviewer for CCTS pilots grants 2014-2016 Director, Center for Free Radical Biology Seminar Series 2015 Serving in CCTS grant discussion panel meetings 2016-present Center for Free Radical Biology Steering Committee 2017-present Nathan Shock Center, UAB, Comparative Mitochondrial Health Assessment

Core director Internal grant discussion and review: 2018 Serving in CCTS grant discussion panel meeting 2018 Serving in CCTS grant review panel 2019 Serving in CCTS pre-grant submission review panel Senate and governess: 2018-present Senate member, Joint Health Sciences, UAB 2018-2019 Faculty Senate Finance committee 2019-present Faculty Senate Council 2019-present Faculty Senate Curriculum committee EDITORIAL BOARD MEMBERSHIPS: 2010-present Brain Research Bulletin (IF 3.103) 2013-present PLoS ONE (IF 2.776)

2013-present American Journal of Pathology (IF 4.069) 2013-present Redox Biology (IF 7.793) 2019-present Free Radical Biology and Medicine (IF 5.87) Reviewer for Research Articles:

Ad hoc reviewer for ~ 50 journals (~50 in 2016, 2017, and 2018 as a reviewer, plus ~ 25 as an academic editor, ~25 as reviewer and ~15 as editor in 2019):

Aging and Diseases: Aging Cell, Aging and disease, BBA Molecular Basis of Diseases,

Apoptosis and Autophagy and Cell Biology: Apoptosis, Autophagy, BBA Molecular Cellular Research, BMC Cell Biology, Cell Death and Differentiation, Cell Research, Experimental Cell Research, Molecular Biology of the Cell, Molecular Cell Biology,

Biochemistry and Pharmacology: Biochemistry and Biophysics Reports, Biochemical Pharmacology, British Journal of Pharmacology, Cell Physiol Biochem, Chem Science, Journal of Biological Chemistry, Toxicological Sciences,

Bioenergetics and Redox biology: Antioxidants & Redox Signaling, Free Radical Biology & Medicine, Free Radical Research, Mitochondrion, Nitric Oxide, Redox Biology, Oxidative Medicine and Cellular Longevity,

Biomedical sciences: Biofactors, FASEB J, Nature Communications, PLoS One, Proc Nat Acad Sci, Scientific Report,

Cancer: BMC cancer, Cancer Research, Molecular Cancer,

Genetics: Human Molecular Genetics, Physiological Genomics,

Neurobiology and Neurodegeneration: BMC Neuroscience; Brain Behavior and Immunity; Brain Research; Brain Research Bulletin, Journal of Gerontology, Journal of Neurochemistry, Journal of Neuroscience, Journal of Neuroscience Research, Molecular Brain, Molecular Neurodegeneration, Molecular Pain, Nature Reviews Neurobiology of Aging, Neurobiology and Diseases, Neurotoxicity Research, Neurochemistry International, Neuroscience, Neuroscience letters, Neurogenetics, Pharmacology Biochemistry & Behavior,

Pathology: Acta Neuropathologica, American Journal of Pathology, J of Histochemistry

Physiology: American Journal of Physiology, Journal of physiology MAJOR RESEARCH INTERESTS: My research focus is to understand the cellular and molecular mechanisms responsible for autophagy, mitophagy and lysosomal functions, how these are linked to redox biology and bioenergetics, and how these mechanisms play important roles in Parkinson’s disease pathogenesis and provide opportunities for therapeutics development. These mechanisms are also important for understanding cell differentiation, proliferation, function and survival, in the context of cancer, diabetes, aging, cardiovascular, lung, liver and Alzheimer’s diseases. I am approaching this by using state of the art genetic models and advanced metabolic and redox related technologies. Since 2011, we have generated and characterized 5 novel mouse models that have helped dissect the role of key cell death and autophagy-lysosomal proteins in protein and organelle homeostasis, cellular bioenergetics and cellular response to oxidative stress in aging and disease models. TEACHING EXPERIENCE: Graduate teaching:

University of Cincinnati College of Medicine 1998 MD/PhD student journal club on neuroscience 1999-2001 Graduate Neuroscience II (Neuroscience: Development, Regeneration, and

Plasticity, lecturer for Apoptosis, and Genes and Learning and Memory) 1999-2005 Survey of Neuroscience (introduction to neuroscience research) 2001-2005 Cell and Molecular Biology Graduate Program Datablitz University of Alabama at Birmingham Traditional didactic lectures (1-2 hour class): 2006 Cell Biology Advance Course "The Cell Cycle and Cancer Genetics", (Cell Death

Mechanisms) 2006 CB 737-VT Graduate Level “Brain Tumor (Glioma) Biology Course”, (Regulation

of Apoptosis in Glioma Tumors) 2006 NBL 712 GradMedNeuro (Neurodevelopment) 2006-2007 NBL 712 GradMedNeuro (Molecular basis of memory) 2006-2008 IBS 703, “Cancer Biology” (Cell death mechanisms) 2006-present NEUR 720, CMB 763, Developmental Neuroscience (Programmed Cell Death in

Development) 2008 HHMI GradMed (Parkinson’s disease Research—pathogenesis and therapy) 2011 NBL 712 GradMedNeuro (Parkinson’s disease) 2011 Undergraduate colloquium directed by Dr. Anne Theibert 2011 ENH 706 doctoral level mitochondrial course (Mitophagy) 2012 GBS 789 CMB Evo-Devo (Evolution of the Nervous System) 2012 Pulmonary/Critical Care division curriculum for T32 grant-Training Program in

Lung Biology and Translational Medicine (Apoptosis and autophagy) 2012 NBL 712 GradMedNeuro (Parkinson Genetics) 2011-2014 GBS 731-PCN Principles of Neuroscience Course (Bioenergetics and diseases in

the nervous system) 2012-present GBS 749 Mitochondria in health and disease (Mitophagy) 2018 GBS709 Lysosomal targeting and degradation, Practical considerations and

disease relevance, 2019 GBS709 Apoptosis and autophagy, Practical considerations and disease

relevance, Course Directors: 2007-present (1 credit hour, 1 contact hour weekly in both spring and fall): NBL 786 Cell Death Mechanisms/Autophagy Journal Club This is an advanced, graduate course that explores the molecular and cellular mechanisms in apoptosis and autophagy, with special emphasis on neurological diseases and mechanisms that underlie the causes, symptoms, and complications of these diseases. I am responsible for overseeing all aspects of logistics for the entire course, including giving specific instructions and expectations, evaluating student presentations, monitoring student participations and collecting/analyzing student evaluations.

Course Co-Director/Faculty: 2008-2014 (1 credit hour, 1.5 contact hour weekly): NBL725 Seminar Practice in Cellular and Molecular Neuroscience This is an advanced graduate course that helps students give formal presentations with appropriate introduction, hypothesis, experimental details, interpretation of data, making clear slides and illustrations, organizing effective presentation, answering questions, and improving/perfecting communication styles. Every student is required to arrive on time with less than 1 late or non-attendance, and each student is required to ask >1 questions in every class. Together with other co-course directors, I spent ~30 min after each of the 1 hour presentation with every student to go over their presentation. Course Development and Course Director: 2011-present 56177 GBS 754 Autophagy in Disease & Med I spend total of ~36 contact hours for this course. This was one of the first new-style innovative “flipped classroom” courses, in which the students lecture and run the classes and are engaged in selection of topics and discussions. As an elective advanced class, this class help students with critical thinking as well as lecturing and presentation. I give lectures on the overview, methods and one of the core concept. I spend significant time helping the students improving their lecturing skills. The students prepare their lectures a week in advance and I will give feedbacks before their lecture. In some cases, I help the student practice sometimes multiple times before their presentations. Students learn more and they do generally ask fact related questions, while I ask thought provoking questions when the students gave lectures. The following class, to help the students further understand and think about the learned material, I also review and quiz what was lectured in prior class. This is a very well received elective class considering it is an intensive class, and the students are genuinely enthusiastic about what they learned. Medical teaching experience: University of Cincinnati College of Medicine: 2001-2002 Microscopic anatomy (Faculty in all the histology laboratory practices for 2 years) University of Alabama at Birmingham: 2007 Medical Cell and Tissue Biology (MCTB) and the Medical Physiology courses, a small

group component termed "Cell Biology and Physiology in Medicine", UAB, 4 meetings 2007 Fundamentals I course for 1st-year medical students, UAB

Small group components – 3 small group meetings: presymptomatic testing for type 2 diabetes, genetic disorders, ion channels and disease

2018-- Education Chair in The American Medical Women’s Association Chapter at UAB. The primary role of the education chair will be to help run the AMWA-sponsored special topics course, 'Women in Medicine and Science,' for the medical students. This academic year, the special topics course will be held the week of 10/15/2018, 12/17/2018, and 12/2019. Curriculum and administrative roles:

2018-- Member of cancer biology curriculum. The primary role of the committee is to evaluate core and elective curriculum, requirement and format of qualifying and thesis defense. 2018 PBMM admission committee 2018-- Education Chair in The American Medical Women’s Association Chapter at UAB. 2019 Senate curriculum committee Curriculum development: 2019 developed and served as founding Co-Director for GBS701 GBS 701 – Core Concepts in Research: Critical Thinking & Error Analysis 1 Credit Hour | Fall 2019 | August 26-December 13, 2019 | Online Course Director: David Schneider, Jianhua Zhang, Tanecia Mitchell Mentoring: Mentoring in University of Cincinnati School of Medicine (1996-2005): Co-mentored 4 graduate students 1996-2005 Involvement: mentoring students with project conceptualization, execution of experiments, qualifying exams, meeting presentations, preparation of manuscripts and dissertations: Ryan Walsh, Jill Slane McQuade, Yang Tang, and Han Lee All obtained their PhD from the University of Cincinnati. Ryan Walsh went on to become an MDPhD fellow in Dept of Neurology in UAB. Jill Slane McQuade joined the US Armed forces in San Antonio working on stress regulations in the hypothalamo-pituitary-adrenal Saxis. Yang Tang went on to become an MDPhD resident in University of Chicago. Han Lee stayed in U of Cincinnati to complete his MSTP training. Co-mentored 7 postdocs 1996-2005 Yihe Guo, Hong Wang, Xiaoshu Wang, Dongsheng Zhang, Lu Zhang, Qi Zhang and Hongyuan Jiao Served on 8 graduate student qualifying committees 1996-2005 Neuroscience program: Miyuki Tauchi Cell and Molecular Biology program: Huajing Wan, Hasan Siddiqui, Nikolaos Nikolaidis, Emily Bosco, Wes Braden, Kevin Link and Gunnar Johansson Served on 4 graduate student dissertation committees 1996-2005 Neuroscience program: Jill Slane McQuade Cell and Molecular Biology program: Jackie McEntire, Michael Markey and Janet Hess-Wilson Mentored 5 rotation students 1996-2005 Huajing Wan (now Faculty, Sichuan University), Miyuki Tauchi (now Faculty, University Hospital Erlangen, Erlangen, Germany), Jeremy S. Hilty Elisia Tichy (postdoc U Penn) Jane Allendorfer (now Faculty, UAB Neurology)

Mentored 8 undergraduate students 1996-2005 Ryan King who later went to graduate school in U Penn, Seint The Su Lwin who later went to the U Cincinnati College of Medicine in the Physician Scientist Training Program, PSTP, Nicholas Toepfer who later went to Med School in U Cincinnati (now a resident in Geisinger Medical Center's Urology Department), Vivek Ramaswamy who went to Harvard University, Emily Doerger who later went to graduate school at University of Cincinnati, Katie Zeller who went to graduate school in Washington University, Heather Fry Jaysson Brooks (who won a national minority student research award for poster presentation) Mentored 2 postdocs 1996-2005 2002-2004 Yong-Fei Wu, MD/MS Current position: Forensic Scientist at Illinois State Police 2002-2004 Mei Dong, PhD Current position: Research Associate, Children’s Hospital Research Foundation, Cincinnati Mentoring in University of Alabama at Birmingham (2005-present): Mentored >20 rotation students 2005-present 2005-2011: Greg White (CMB), John Cutts (IBS), Patrick L Garcia (IBS), Donna Crabtree (IBS), Lorra Hyland (IGGP), Lonnie Schneider (IBS), Thomas Reed Peavy (neuroscience), Erin McCoy (MCP/HHMI), Joshua Sammons (CMB), Aimee Vinson (IBS/HHMI), Andrea Marshall (Neuroscience/HHMI), Michael Edwards (CMB), Lital N Silverman (IBS) Since 2011: Samantha Giordano (IBS), Matthew Dodson (CMDB), Matthew Redmann (CMDB), Hai Vo (CMDB), Nathaniel Bone (PBMM), Madeline Scott (Neuroscience), 2018.10-12 Alexandria Nichols (PBMM), 2019.07-2019.08 Prathibha Sekar (Neuroscience), 2020.04-06 Miranda Chavez (Immunology) Mentored 16 undergraduate students 2005-present 2005-2011: Jasmine M. Olander (Molecular Cellular Pathology PREP program); Matthew Julian English (Neurobiology SPIN program); Eva Yuan (Biology); Lisa Speake (PREP, Birmingham Southern, who later came to UAB med school); Rachael Park (SPIN, MVNU); Finn Perkins (UAB undergraduate science and technology honor program); Morgan Anders (UAB undergraduate honor program); Toni Mueller (SPIN, WIU, who later came to UAB graduate school); Meghana Kukkamalla (UAB); Divya Alapati (UAB); Tonya Cassady (UAB) Since 2011: Diane Luong (UAB who then became a UAB medical student after my lab); Carlene Robinson (UAB biology class of 2016); Venkata Sivaram Tekumalla (UAB Sci-Tech Honor class of 2016); 2017 Matthew Houston Bonds (UAB undergraduate Neuroscience Program, class of 2019); 2018 Allison Raymundo (UAB SIBS, summer of 2018) Mentored 2 high School students

2009 summer Arina Ghosh (Alabama School of Fine Art) then became a medical student in Kansas 2009 summer Edward S. Li (Hoover High School) then became a college student in Furman

University Served on 1 graduate student qualifying committees (University of Alabama at Birmingham):

2010 Michael Edward (Cell and Molecular Biology, UAB)

Served on 10 student dissertation committees 2006-2009 Keertik Fulzele (Molecular Cellular Pathology, PhD 2009, now postdoc in

Harvard Medical School), 2006-2009 Ken C Walls (Cell and Molecular Biology, PhD 2009, now postdoc in UC Irvine), 2007-2010 Shusei Hamamichi (The University of Alabama, Tuscaloosa PhD 2010, now

postdoc in MIT), 2007-2010 Terry L Lewis (Molecular Cellular Pathology, PhD 2010, now a core director in

UAB) 2008-2009 Shay Hyman (Neuroscience, deceased), 2011-2013 Leandra R. Mangieri (MS 2013, Biology, now in PhD program in UT Houston) 2008-2013 Lurong Pan (Chemistry, PhD 2013, now have a job in Industry) 2008-2014 Hongyi Yang (Chemistry, PhD 2014), 2015-present Jalessa N Wright (Molecular Cellular Pathology, UAB) 2017-2018 Gerardo Hernandez-Moreno (UAB undergraduate honor program) 2019-present Shreya N Kashyap (MSTP/neuroscience, committee chair) 2019-present Kaysaw C Tuy (BSSB)

Mentoring committee for junior faculty (University of Alabama at Birmingham): 2012 Assistant Professor, Hyunsoo Kim, Bioinformatics Division, Dept of Pathology, UAB Serving as a collaborator in F31 of a graduate student

2018 Rachel N Underwood (UAB neuroscience, Rab27b promotes αsyn-mediated neurotoxicity by inducing the release and spread of αsyn)

Serving in postdoc scientific advisory committee 2018 Rashid Harunur (UAB School of Dentistry, K99/R00 application on role of Runx2 in

apoptosis of hypertrophic chondrocytes during normal development of endochondral bone) 2015-present Contributing to training grant applications:

• UAB NEUROSCIENCE ROADMAP SCHOLARS PROGRAM NIH/NINDS R25RNS089463A-03,

• TRAINING PROGRAM IN THE NEUROBIOLOGY OF COGNITION AND COGNITIVE DISORDERS NIH/NINDS T32NS061788-09,

• UAB Training Program In Neuroscience T32NS095775-01, • T32 training grant for aging research • T32 training grant for translational research • Education Core for the ADRC P30

Mentored 13 postdocs and Visiting Scholars Current position 2006-2006 Canquan Mao, PhD Director, School of Bioengineering Southwest Jiaotong University 2006-2006 Jun Lu, MD Surgeon, Military Med Hospital, (1 paper) Beijing, 2006-2007 Liyan Qiao, MD/PhD Physician, Tsinghua University (2 papers) Hospital 2007-2008 Stephen Crimmins, PhD (2 paper) Biochemist, US Army 2009-2009 Weibin Shi, MD/PhD Physician, Penn State Hershey Phys Med & Rehab 2011-2012 Jisun Lee, PhD (2 papers) Research associate, The Catholic

University of Korea 2012-2013 Michaël Boyer-Guittaut, PhD Faculty, Université de Franche- (7 papers) Comté (visiting scientist) 2008-2014 Qiuli Liang, PhD (SfRBM travel award) Postdoc, UAB public health (8 papers) 2013-2015 Israr Ahmad, PhD Research Associate, Anesthesiology

UAB 2014-2017 Willayat Wani, PhD (SfRBM travel award and oral presentation) Postdoc, Northwestern University (8 papers) 2018.11-2019.10 Yecheng, PhD Lecturer, Suzhou Vocational Health

College

2019.01-09 Helen Collin, PhD Res track Assis prof, U of Louisville 2019.03-present Selma Kane, PhD 2019.03-present Joo-Yeun Oh, PhD Mentored 5 graduate students for PhD in UAB (Currently mentoring 1): 2007-2012 Donna Crabtree (Integrative Biological Sciences, UAB) studied a mouse model of lysosomal deficiency in pathogenesis of Parkinson’s disease and validation of strategies to enhance lysosomal activities using adeno-associated virus and lenti-virus to attenuate neurodegeneration in α-synuclein and MPTP/MPP+ based cell and animal models. She passed her qualifying exam August 2009, published 1 first authored review article, 1 co-authored research article, and 2 first-authored research articles (total of 4 papers, 3 as first author). She gave several presentations in national conferences and university-wide retreats and research day symposiums, won 1) a UAB graduate research presentation third place prize in 2012, 2) Department of Pathology and 3) UAB graduate student travel awards to present in Experimental Biology conference in 2012, and defended her PhD thesis June 25, 2012. She started her postdoc position on pediatric cancer with Dr. Becher at Duke University in August 2012. In 2016 she took a position where she acts as the liaison for clinical trials at Duke. 2008-2012 Lonnie Schneider (Integrative Biological Sciences, UAB) studied molecular and cellular mechanisms of general and selective macroautophagy in decreasing the accumulation of damaged proteins and organelles, in the contexts of Parkinson’s and Huntington’s disease using cell lines, primary neurons, and mouse models. He passed his qualifying exam May 2010, published 3 co-authored articles, 1 first authored review, and 1 co-first authored research article (total of 5 papers, 2 as first author). He gave well-received lectures in the Autophagy course for which I have been a course master. He won 1) a Department of Pathology and 2) a Center for Free Radical Biology travel award to present in Society for Free Radical Biology and Medicine conference in 2011. He defended his PhD thesis May 25, 2012, joined Dr. Manisha Patel (U of Colorado)’s laboratory as a postdoc working on epilepsy in June 2012, and joined Candace Floyd’s laboratory (UAB) for a second postdoc working on traumatic brain injury in July 2013. He became a tenure-track assistant professor in the School of Medicine, Physical Medicine and Rehabilitation Department at UAB in November 2016, and moved to Univ Utah 2017 as a junior faculty. 2010-2014 Samantha Giordano (Integrative Biological Sciences, UAB) worked on neurotoxin rotenone-induced mitochondrial dysfunctions and cell death; and the protective role of autophagy. In my lab, she has published 1 co-first authored research article, 1 co-first authored review article, 1 co-authored method paper, 1 first author review, and 2 first author research article (total of 6 papers, 5 as first author). She received travel awards from 1) the Department of Pathology, 2)

UAB graduate school, 3) Center for Free Radical Biology, and 4) Society for Free Radical Biology and Medicine, to present in Society for Free Radical Biology and Medicine conference in 2010, 2011, 2012, and 2013. She also won a Graduate School retreat poster presentation 2nd place award. She was also trained in giving lectures to graduate students, and reviewing manuscripts. She joined UAB Vascular Biology as a postdoc, and was awarded a T32 postdoctoral fellowship on hypertension in May 2014. She became a tenure track assistant professor in School of Health Professions, UAB in July 2017. 2011-2015 Matthew B Dodson (Cell, Molecular and Developmental Biology, UAB) is studying the signaling pathways between autophagy, oxidative stress and glycolytic activities. He passed his qualifying exam in October 1, 2012. He won a Department of Pathology and a Center for Free Radical Biology travel awards to present in Society for Free Radical Biology and Medicine conference in 2011, 2012, and 2013. He received 1) a poster presentation award in Center for Aging conference at UAB, and 2) a young investigator award in Society for Free Radical Biology and Medicine conference in 2012. He has 2 first author Review article published in FRBM and Biochem J, and 2 first author Research Article in Autophagy, and 3 co-authored research articles in J Neurochemistry and FRBM, and 2 co-authored reviews (total of 9 papers 4 as first author, one more first author in preparation). He has also been trained in giving lectures to graduate students, and reviewing manuscripts. He was also recognized as the recipient of the Department of Cell, Developmental, and Integrative Biology Outstanding Student Award for 2015. He joined the University of Arizona Toxicology program as a postdoc, and was awarded a T32 postdoctoral fellowship in June 2015. 2013-2017 Matthew Redmann (Cell, Molecular and Developmental Biology, UAB) joined my lab May 1, 2013 to study effects of oxidative stress and antioxidants in regulation of autophagy in aging and degenerative diseases. He won 1) a Department of Pathology and 2) a Center for Free Radical Biology travel awards to present in Society for Free Radical Biology and Medicine conference in 2013 and 2014. He has 5 co-author research articles in Autophagy, J Neurochemistry, and Molecular Brain; 2 first author review in International Journal of Biochemistry and Cell Biology, Aging and diseases; 2 first author research articles in Redox Biology, 1 first author method paper (total of 10, 5 as first author). He defended his thesis January 2017 and then took a job as Head of Business Development and Senior Scientist in DiscoveryBioMed with Dr. Erik Schwiebert. 2019.07-08 Prathibha Sekar (Neuroscience), joined my lab after a rotation. She will be studying the role of O-GlcNAcylation in regulation of autophagy and protein trafficking in neurons and glia. Recent non-PhD students: 2017.07-2018.06 Jason Craver (Research Assistant, 2017 UAB BS) Jason worked on autophagy and mitochondrial protein levels in a variety of cell culture, animal and human samples from the blood, liver, lung, heart, and brain. He co-authored a review article and is in other manuscripts in preparation. He has contributed as a co-author in a published review article, and also won a poster presentation award at the 2018 Pathology Trainee Research Day ($100). 2018.06-2018.07 Allison Raymundo (Summer in Biomedical Sciences (SIBS) Undergraduate Research Program for sophomore and junior undergraduate student)

Allison worked on autophagy in young and aged mouse tissues, as well as in rat model of AD. She is a very talented and motivated student. I hope to help recruiting her to MSTP/UAB once she graduate from UCLA. 2018.09-2019.07 Gerardo Hernandez-Moreno, BS UAB (Research Assistant) Gerardo worked on mitophagy and mitochondrial function in circadian clock – O-GlcNAc – diabetes heard disease. 2019.09-present Parker Jeffrey (undergraduate, biomedical sciences program, UAB) Parker will work on using microscopy to study circadian regulation of mitophagy and mitochondrial structure in the heart.

Current Student, Postdoc and Research Associate: 2010-present Xiaosen Ouyang, MD (Research Associate) Xiaosen is studying the role of autophagy regulation and neurodegeneration in mouse knock-out and knock-in models. She had 8 years of postdoc experience in pathology and oxidative stress field, and published 16 papers prior to joining my lab. She is essential for all lab management and assisting everybody in research techniques and has contributed as a co-author in >10 research articles in my lab, and won a PTRD award. She is currently half time due to family obligations. 2018-present David Westbrook (MS. Researcher III) David had a MS on microbiology in 1998, worked in various research positions in U Arkansas, Alabama A&M, Invitrogen and UAB. Before joining my laboratory, he published 12 papers as first and co-authors. In my lab, he is working on alpha synuclein fibril spread in rodent brains and toxicity, impact of lysosomal enhancement strategies on pathogenesis, and novel regulation mechanisms of autophagy in mammalian brains. 2018.11- 2019.10 Yecheng He (PhD, Visiting Scholar) Yecheng had a PhD from Nanjing University, and had experience in neurophysiology and published 4 peer reviewed manuscript (1 as first author). He is currently a lecturer in Suzhou Vocational Health College. He will be working in my laboratory for 1 year, focusing on alpha-synuclein fibril spread in rodent brains and toxicity, impact of lysosomal enhancement strategies on pathogenesis, and novel regulation mechanisms of autophagy in mammalian brains. 2019.01-2019.09 Helen Collins (PhD, postdoc/research associate, 50% effort) Helen had a PhD from University of Leicester in 2011, and a postdoc with Dr. Chatham 2012-2018. She has training in cardiovascular biology, calcium signaling and had 10 peer reviewed publications. She had multiple postdoctoral fellowships from American Diabetes Association, American Heart Association, and William Featheringill UAB comprehensive cardiovascular center, as well as a pilot grant from Nathan Shock Center. She will be working on mitophagy in circadian regulation and heart disease. 2019.03- Mariame Selma Kane (PhD, postdoc, 50% effort) Mariame had a PhD from University of Angers, France in 2016, and a postdoc in the same institute till August 2018. She has training in mitochondrial medicine, mitochondrial dynamics, mitophagy and published 2 first author and 7 co-authored peer reviewed publications and recently submitted 3 more first authored publications while she moved back to the US to be with her Mother. She has been recruited to UAB and received T32 on hypertension. She will be working on mitophagy in circadian regulation and heart disease.

2019.03- Joo-Yeun Oh (PhD, research associate, 50% effort) Joo-Yeun had a PhD from UAB in 2008, and a postdoc with Drs. Landar in UAB, Phil Eaton in UK, and Dr. Patel in UAB. Then she was promoted to Researcher V from 2014 with Dr. Patel. She has training and experience in broad area of redox biology had 25 peer reviewed publications, and several awards in SfRBM and GRC meetings, as well as several UAB internal research presentations. She will be working on autophagy and mitophagy regulation by O-GlcNAcylation. Mentor for Mentees in other institution: Mentored 1 undergraduate foreign mentee through SFRBM mentoring system:

2010-2011 Alejandro Garcia Cruz (UFABC)—3rd year of undergraduate in Bioengineering in Brazilian federal university (UFABC), studying Prion Protein complexed with cooper (Cu I - II) and its behavior in oxidative medium caused by free radicals. My role is to email regularly regarding scientific and career advice.

Mentored 2 graduate student mentee and 3 postdoc mentee through SFRBM mentoring system:

2012 Ching-Fang Chang (Medical College of Wisconsin)—5th year graduate student in Department of Biophysics.

2013 Chao He (University of Iowa)—4th year graduate student in Department of Radiation Oncology

2013 Shane Kruse (University of Washington)—postdoc seeking an independent position

2015 Cathryn Haigh (University of Melbourne)--postdoc 2017 Maren C Podszun (NIH/NIDDK)—postdoc

BIBLIOGRAPHY: MANUSCRIPTS (H-factor 48, i10-index 104, total citations >13,000): https://scholar.google.com/citations?hl=en&user=nHLXgEAAAAAJ Research articles: 1. Zhang J, Liu Z-P, Jones TA, Gierasch L, Sambrook JF (1992) Mutating the charged residues in

the binding site of cellular retinoic acid-binding protein (CRABP) simultaneously increases its thermostability and reduces its binding affinity. Protein: Structure, Function, and Genetics 13:87-99 (with cover)

2. Zhang J, Liao S-M, Jeffrey DA, Koleske AJ, Thompson CM, Chao DM, Viljoen M, van Vuuren HJJ, Young RA (1995) A kinase-cyclin pair in the RNA polymerase II holoenzyme. Nature 374:193-196 (co-first author) (with news and views by O'Neill EM and Erin O’Shea: “Transcriptional regulation. Cyclins in initiation”)

3. Clark PL, Liu Z-P, Zhang J, Gierasch LM (1996) Intrinsic tryptophans of CRABPI as probes of structure and folding. Prot Sci 5:1108-1117

4. Hengartner CJ, Thompson CM, Zhang J, Chao DM, Liao S-M, Koleske AJ, Young RA (1995) Association of an activator with an RNA polymerase II holoenzyme. Genes & Dev 9:897-910

5. Zhang J, Liu X, Scherer DC, Van Kaer L, Wang X, Xu M (1998) Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45. Proc Natl Acad Sci USA 95: 12480-12485 (with commentary by Susan Cory: “Cell death throes”) PMCID:PMC22856

6. Zhang J, Wang X, Bove K, Xu M (1999) DNA fragmentation factor 45 deficient cells are more resistant to apoptosis and exhibit different dying morphology than wild-type control cells. J Biol Chem 274:37450-37454

7. Slane J, Lee H, Vorhees CV, Zhang J, Xu M (2000) DNA fragmentation factor 45 deficient mice exhibit enhanced spatial learning and memory compared to wild-type control mice. Br Res 867:70-79

8. Zhang J, Lee H, Lou DW, Boivin GP, Xu M (2000) Lack of obvious 50 kilobase pair DNA fragments in DNA fragmentation factor 45 deficient thymocytes upon activation of apoptosis. Biochem Biophy Res Comm 274:225-229

9. Xu M, Guo Y, Vorhees CV, Zhang J (2000) Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor. Br Res 852:198-207

10. Zhang J, Xu M (2000) DNA fragmentation in apoptosis. Cell Res 10:205-211 11. Zhang J, Xu M (2001) Toward a molecular understanding of psychostimulant actions using

genetically engineered dopamine receptor knockout mice as model systems. J Addictive Diseases 20:7-18

12. Yakovlev AG, Di X, Movsesyan V, Mullins PGM, Wang G, Boulares H, Zhang J, Xu M, Faden AI (2001) Presence of DNA fragmentation and lack of neuroprotective effect in DFF45 knockout mice subjected to traumatic brain injury. Mol Medicine 7:205-216 PMCID:PMC1950023

13. Zhang J, Lee H, Agarwala A, Lou DW, Xu M (2001) DNA fragmentation factor 45 mutant mice exhibit resistance to kainic acid-induced neuronal cell death. Biochem Biophy Res Comm 285:1143-1149

14. Hobbs JA, Cho SY, Roberts TJ, Sriram V, Zhang J, Xu M, Brutkiewicz R. (2001) Selective loss of natural killer T cells by apoptosis following infection with lymphocytic choriomeningitis virus. J Virol 75:10746-10754 PMCID:PMC114656

15. Zhang J, McQuade JS, Vorhees C, Xu M (2002) Hippocampal expression of c-fos is not essential for spatial learning. Synapse 46:91-99

16. Zhang J, Zhang D, McQuade JS, Behbehani M, Tsien J, Xu M (2002) C-fos regulates neuronal excitability and survival. Nature Genet 30:416-420

17. Zhang J, Xu M (2002) Apoptotic DNA degradation and tissue homeostasis. Trends Cell Biol 12:84-89

18. Jin W, Zhang J, Lou D, Chavkin C, Xu M (2002) c-fos-deficient hippocampal CA3 pyramidal neurons exhibit both enhanced basal and kainic acid-induced excitability. Neurosci Lett 331:151-154

19. McQuade JS, Vorhees C, Xu M, Zhang J (2002) DNA fragmentation factor 45 knockout mice exhibit longer memory retention in the novel object recognition task compared to wild-type mice. Physiol & Beh 76:315-320

20. Zhang J, Xu M, Aronow B (2002) Expression profiles of 109 apoptosis pathway-related genes in 82 mouse tissues and experimental conditions. Biochem Biophy Res Comm 297:537-544

21. Zhang D, Zhang L, Lou D, Nakabeppu Y, Zhang J, Xu M (2002) The dopamine D1 receptor is a critical mediator for cocaine-induced gene expression. J Neurochem 82:1453-1464

22. Pritchard LM, Logue AD, Hayes S, Welge JA, Xu M, Zhang J, Berger SP, Richtand NM (2003) 7-OH-DPAT and PD 128907 selectively activate the D3 dopamine receptor in a novel environment. Neuropsychopharmacol 28:100-107

23. Zheng W, Xie W, Zhang J, Strong JA, Wang L, Yu L, Xu M, Lu L (2003) Function of gamma-aminobutyric acid receptor/channel rho 1 subunits in spinal cord. J Biol Chem 278:48321-48329

24. Zhang J, Dong M, Li L, Fan Y, Pathrie P, Dong J, Olivares-Villagom D, Lou D, Wells J, Van Kaer L, Wang X, Xu M (2003) Endonuclease G is required for early embryogenesis and normal apoptosis in mice. Proc Natl Acad Sci USA 100:15782-15787 co-corresponding author

25. Zhang L, Lou D, Jiao H, Zhang D, Wang X, Xia Y, Zhang J, Xu M (2004) Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors. J Neurosci 24:3344-3354

26. Zhang J, Moseley A, Jegga AJ, Gupta A, Witte DP, Sartor M, Williams SS, Ley-Ebert C, Coolen L, Egnaczyk G, Genter MB, Lehman M, Lingrel J, Maggio J, Parysek L, Walsh R, Xu M, Aronow BJ (2004) Neural system-enriched gene expression, relationship to biological pathways and neurological diseases. Physiological Genomics 18, 167-183 co-corresponding author

27. Wu Y, Zhang D, Lou D, Fan Y, Aronow B, Xu M, Zhang J (2004) c-fos regulates neuropeptide Y expression in mouse dentate gyrus. Neurosci Lett 363:6-10

28. Wu Y, Dong M, Toepfer NJ, Fan F, Xu M, Zhang J (2004) Role of Endonuclease G in neural excitotoxicity in mice. Neurosci Lett 364:203-207

29. Xu M, Zhang J (2004) Molecular genetic probing of dopamine receptors in drug addiction. Current Opinion in Drug Discovery & Development 7:703-708

30. Rui T, Feng Q, Lei M, Peng T, Zhang J, Xu M, Abel ED, Xenocostas A, Kvietys PR (2005) Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion induction of AP-1. Cardiovascular Research 65:719-27

31. Zhang D, Zhang L, Zhang Q, Tang Y, Lou D, Sharp FR, Zhang J, Xu M (2005) Repeated cocaine administration induces gene expression through the dopamine D1 receptors. Neuropsychopharmacol 30:1443-1454

32. Zhang J, Zhang L, Jiao H, Zhang Q, Zhang D, Lou D, Katz JL, Xu M (2006) c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes. J Neurosci 26:13287-13296

33. Dong M, Wu Y, Fan Y, Xu M, Zhang J (2006) c-fos modulates brain-derived neurotrophic factor mRNA expression in mouse hippocampal CA3 and dentate gyrus neurons. Neurosci Lett 400:177-180

34. McQuade JS, Tamashiro K, Wood G, Herman JP, McEwen BS, Sakai RR, Zhang J, Xu M (2006) Deficient hippocampal c-fos expression results in reduced anxiety and altered response to chronic stress in female mice. Neurosci Lett 403:125-30 (co-corresponding author)

35. McNamara RK, Logue A, Stanford K, Xu M, Zhang J, Richtand NM (2006) Dose-response analysis of locomotor activity and stereotypy in dopamine D3 receptor mutant mice following acute amphetamine. Synapse 60:399-405 PMCID:PMC1815379

36. Li Q, Li H, Blitvich BJ, Zhang J (2007) The Aedes albopictus inhibitor of apoptosis 1 gene protects vertebrate cells from bluetongue virus-induced apoptosis. Insect Mol Biol 16:93-105

37. Shacka J, Lu J, Xie Z, Uchiyama Y, Roth K, Zhang J (2007) Kainic acid induces early and transient autophagic stress in mouse hippocampus. Neurosci lett 414:57-60. PMCID: PMC1839881

38. Zhou Y, Adomako-Mensah J, Yuferov V, Ho A, Zhang J, Xu M, Kreek MJ (2007) Effects of acute "binge" cocaine on mRNA levels of mu opioid receptor and neuropeptides in dopamine D1 or D3 receptor knockout mice. Synapse 61:50-9

39. Pritchard L, Newman AH, McNamara RK, Logue AD, Taylor B, Welge JA, Xu M, Zhang J, Richtand NM (2007) The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion. Pharm Biochem Beh 86:718-26

40. Dong M, Fan Y, Toepfer NJ, Zhang J (2007) Deficiency of DNA fragmentation factor 45 results in reduced oocyte apoptosis in response to doxorubicin. Cell Res 17:735-6

41. Jiao H, Gao F, Lou D, Zhang J, Xu M (2007) Dopamine D1 and D3 receptors oppositely regulate NMDA- and cocaine-induced MAPK signaling via NMDA receptor phosphorylation. J Neurochem 102:840-848

42. Caine SB, Thomsen M, Gabriel KI, Berkowitz JS, Gold LH, Koob GF, Tonegawa S, Zhang J, Xu M (2007) Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice. J Neurosci 27:13140-13150 PMCID:PMC2747091

43. Ness J, Harvey C, W Jason, Roth K, Carroll S, Zhang J (2008) Differential activation of c-Fos and caspase-3 in hippocampal neuron subpopulations following neonatal hypoxia-ischemia. J Neuroscience Res 86:1115-24

44. Qiao L, Hamamichi S, Caldwell KA, Caldwell GA, Yacoubian TA, Wilson S, Xie ZL, Speake LD, Parks R, Crabtree D, Liang Q, Crimmins S, Schneider L, Uchiyama Y, Iwatsubo T, Zhou Y, Peng L, Lu YM, Standaert DG. Walls KC, Shacka JJ, Roth KA, Zhang J (2008) Lysosomal enzyme cathepsin D protects against α-synuclein aggregation and toxicity. Molecular Brain 1:17. PMCID:PMC2600785

45. Hu XT, Nasif FJ, Zhang J, Xu M (2008) Fos regulates neuronal activity in the nucleus accumbens. Neurosci Lett 448:157-60

46. Shacka J, Roth K, Zhang J (2008) The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy. Frontiers in Bioscience 13:718-36

47. Qiao L, Zhang J (2009) Inhibition of lysosomal functions reduces proteasomal activity. Neurosci Lett 456:15-19

48. Schneider L, Zhang J (2010) Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease. Molecular Neurodegeneration 5:14. PMCID: PMC2867960

49. Walls KC, Ghosh AP, Franklin AL, Klocke BJ, Ballestas M, Shacka JJ, Zhang J, Roth KA (2010) Lysosome dysfunction triggers Atg7-dependent neural apoptosis. J Biol Chem 285:10497-507. PMCID:PMC2856257

50. Jegga A, Schneider L, Ouyang X, Zhang J (2011) Systems biology of the autophagy-lysosomal pathway. Autophagy 7:5, 1-13. PMCID:PMC3127210

51. Liang Q, Ouyang X, Schneider L, Zhang J (2011) Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons. Molecular Neurodegeneration 6:37. PMCID:PMC3164227

52. Dranka BP, Benavides GA, Diers AR, Giordano S, Zelickson BR, Reily C, Zou L, Chatham J, Hill BG, Zhang J, Landar A, and Darley-Usmar VM (2011) Assessing bioenergetic function in response to oxidative stress by metabolic profiling. Free Radical Biology and Medicine 51:1622-1635 PMCID:PMC3548422

53. Schneider L, Giordano S, Zelickson BR, Johnson MA, Benavides GA, Ouyang X, Fineberg N, Darley-Usmar VM, Zhang J (2011) Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress. Free Radical Biology and Medicine 51:2007-2017. PMCID:PMC3208787

54. Jaber N, Dou Z, Chen JS, Catanzaro J, Jiang YP, Ballou LM, Selinger E, Ouyang X, Lin R, Zhang J, Zong WX (2012) The Class III PI3K Vps34 plays an essential role in autophagy and in the heart and liver function. Proc Nat Acad Sci USA 109:2003-2008. Co-corresponding author. PMCID: PMC3277541

55. Jaber N, Dou Z, Lin RZ, Zhang J, Zong WX (2012) Mammalian PIK3C3/VPS34: The key to autophagic processing in liver and heart. Autophagy 8:4, 707-708

56. Higdon AN, Benavides GA, Chacko B, Ouyang X, Johnson MS, Landar A, Zhang J, Darley-Usmar VM (2012) Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy. American Journal of Physiology 302(7):H1394-409. PMCID:PMC3330785

57. Klionsky et al (Zhang J as one of 1270 co-authors) (2012) Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy in Higher Eukaryotes. Autophagy 8:4, 445-544. PMCID:PMC3404883

58. Giordano S, Lee J, Darley-Usmar VM, Zhang J (2012) Distinct effects of rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on cellular bioenergetics and cell death. PlosOne 7(9):e44610. PMCID:PMC3435291

59. Cummins TD, Higdon AN, Kramer PA, Chacko B, Riggs DW, Salabei JK, Dell’Italia LJ, Zhang J, Darley-Usmar VM, Hill BG (2012) Utilization of fluorescent probes to identify subcellular proteomes and processes regulated by lipid peroxidation products. Free Radical Biology and Medicine 59:56-68. PMCID:PMC3522791

60. Crabtree D, Zhang J (2012) Genetically engineered mouse models for Parkinson’s diseases. Brain Research Bulletin 88:13-32. PMCID:PMC3244549

61. Lee J, Giordano S, Zhang J (2012) Autophagy, mitochondrial and oxidative stress: cross-talk and redox signaling. Biochemical Journal 441:523-540. PMCID:PMC3258656

62. Hill B, Benavides G, Lancaster J, Ballinger S, Dell’Italia L, Zhang J, Darley-Usmar VM (2012) Integration of cellular bioenergetics with mitochondrial quality control and autophagy. Biological Chemistry 393:1485-1512. PMCID:PMC3594552

63. Mitchell T, Chacko B, Ballinger SW, Bailey SM, Zhang J, Darley-Usmar VM (2013) Convergent mechanisms for mitochondrial dysfunction in metabolic disease; insights from mitochondrial therapeutics. Biochemical Society Transactions 41:127-133 PMCID:PMC3582193

64. Zhang J (2013) Autophagy and mitophagy in cellular damage control. Redox Biology 1:19-23. PMCID:PMC3740586

65. Dodson M, Darley-Usmar V, Zhang J (2013) Cellular metabolic and autophagic pathways: traffic control by redox signaling. Free Radical Biology and Medicine 63:207-221 PMCID:PMC3729625

66. Giordano S, Darley-Usmar V, Zhang J (2013) Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease. Redox Biology 2:82–90. PMCID:PMC3909266

67. Errami Y, Naura AS, Kim H, Ju J, Suzuki Y, El-Bahrawy, AH, Ghonim MA, Hemeida RA, Mansy MS, Zhang J, Xu M, Boulares AH (2013) Apoptotic DNA fragmentation may be a cooperative activity between caspase-activated DNase and the PARP-regulated DNas1L3, an ER-localized endonuclease that translocates to the nucleus during apoptosis. J Biol Chem 288(5):3460-8 PMCID:PMC3561564

68. Errami Y, Brim H Oumouna-Benachour K, Oumouna M, Naura AS, Kim H, Ju J, Kim JG, Ashktorab H, Fallon K, Xu M, Zhang J, Del Valle L, Boulares AH (2013) ICAD deficiency in human colon cancer and predisposition to colon tumorigenesis: linkage to apoptosis resistance and genomic instability. PlosOne 8:e57871 PMCID:PMC3579889

69. Crabtree D, Boyer-Guittaut M, Ouyang X, Fineberg N, Zhang J (2013) Dopamine and its metabolites in cathepsin D heterozygous mice before and after MPTP administration. Neuroscience Letters 538: 3-8 PMCID: PMC3645893

70. Parekh VV, Wu L, Boyd KL, Williams, JA, Gaddy JA, Olivares-Villagomez D, Cover TL, Zong WX, Zhang J, Van Kaer L (2013) Impaired autophagy, defective T cell homeostasis and a wasting syndrome in mice with a T cell-specific deletion of Vps34. Journal of Immunity 190(10):5086-101. PMCID:PMC3646937

71. Le Grand JN, Bon K, Fraichard A, Zhang J, Jouvenot M, Risold P-Y, Boyer-Guittaut M, Delage-Mourroux R (2013) Specific distribution of the autophagic protein GABARAPL1/GEC1 in the developing and adult mouse brain and identification of neuronal populations expressing GABARAPL1/GEC1. PlosOne 8(5):e63133 PMCID:PMC3655077

72. Mitchell T, Johnson MS, Ouyang X, Chacko BK, Mitra K, Lei X, Gai Y, Moore DR, Barnes S, Zhang J, Koizumi A, Ramanadham S, Darley-Usmar VM (2013) Dysfunctional mitochondrial

bioenergetics and oxidative stress in Akita+/Ins2-derived β-cells. American J of Physiology 305(5):E585-99. PMCID:PMC3761167

73. Liang Q, Benavides G, Vasilopoulos A, Gius D, Darley-Usmar V, Zhang J (2013) Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts. Biochemical Journal 454:249-257 PMCID:PMC3927421

74. Benavides GA, Liang Q, Dodson M, Darley-Usmar V, Zhang J (2013) Inhibition of autophagy and glycolysis by nitric oxide during hypoxia-reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons. Free Radical Biology and Medicine 65:1215-1228 PMCID:PMC3859859

75. Dodson M, Liang Q, Johnson M, Redmann M, Fineberg N, Darley-Usmar V, Zhang J (2013) Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cells. Autophagy 9:1996-2008. PMCID:PMC4028343

76. Crabtree D, Dodson M, Ouyang X, Boyer-Guittaut M, Liang Q, Ballestas M, Fineberg N, Zhang J (2014) Overexpression of an inactive mutant cathepsin D increases endogenous alpha-synuclein and cathepsin B activity in SH-SY5Y cells. J Neurochem 128:950-61. PMCID:PMC3951679

77. Boyer-Guittaut M, Poillet L, Liang Q, Bôle-Richard E, Ouyang X, Benavides GA, Chakrama F-Z, Fraichard A, Darley-Usmar VM, Despouy G, Jouvenot M, Delage-Mourroux R, Zhang J (2014) The role of GABARAPL1 (GEC1) in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells. Autophagy 10:6,986-1003 PMCID:PMC4091181

78. Chacko B, Kramer P, Ravi S, Benavides G, Mitchell T, Dranka BP, Ferrick D, Singal A, Ballinger S, Bailey SM, Hardy R, Zhang J, Zhi D, Darley-Usmar VM (2014) The Bioenergetic Health Index: A new concept in translational research. Clinical Science 127:367-373 PMCID:PMC4202728

79. Giordano S, Dodson M, Ravi S, Ouyang X, Redmann M, Darley-Usmar V, Zhang J (2014) Bioenergetic adaptation in response to autophagy regulators during rotenone exposure. J Neurochem 131:625-33 PMCID:PMC4454361

80. Sheshadri N, Catanzaro J, Bott A, Sun Y, Ullman E, Chen E, Pan J-A, Wu S, Crawford H, Zhang J, Zong WX (2014) SCCA1/SerpinB3 promotes epithelial-mesenchymal transition and oncogenic transformation via unfolded protein response and IL-6 signaling. Cancer Research 74:6318-29 PMCID:PMC4216755

81. Levonen AL, Hill BG, Kansanen E, Zhang J, Darley-Usmar VM (2014) Redox regulation of antioxidants, autophagy and the response to stress; implications for electrophile therapeutics. Free Radical Biology and Medicine 71:196–207. PMCID:PMC4042208

82. Redmann M, Dodson M, Boyer-Guittaut M, Darley-Usmar VM, Zhang J (2014) Mitophagy mechanisms and role in human diseases. International Journal of Biochemistry and Cell biology 53C:127-133. PMCID:PMC4111979

83. Allison D, Antoine L, Ballinger S, Bamman M, Biga P, Darley-Usmar V, Fisher G, Gohlke J, Halade G, Hartman J, Hunter G, Messina J, Nagy T, Plaisance E, Roth K, Sandel M, Schwartz T, Smith D, Sweatt JD, Tollefsbol T, Watts S, Yang Y, Zhang J, Austad S (2014) Aging and Energetics’ ‘Top 40’ Future Research Opportunities 2010-2013. F1000Research 12;3:219 PMCID:PMC4197746

84. Wani W, Boyer-Guittaut M, Dodson M, Chatham J, Darley-Usmar V, Zhang J (2015) Regulation of autophagy by protein post-translational modification. Laboratory Investigation 95:14-25. PMCID:PMC4454381

85. Zhang J (2015) Teaching the basics of autophagy and mitophagy to redox biologists—mechanisms and experimental approaches. Redox Biology 4:242-259 PMCID:PMC4803799

86. Dodson M, Redmann M, Rajasekaran, NS, Darley-Usmar V, Zhang J (2015) KEAP1-NRF2 signaling and autophagy in protection against oxidative and reductive proteotoxicity. Biochem Journal 469:347-355. PMCID:PMC5514546

87. Jurkuvenaite A, Benavides GA, Komarova S, Doaran SF, Johnson M, Aggarwal S, Zhang J, Darley-Usmar VM, Matalon S (2015) Upregulation of autophagy decreases chlorine gas induced mitochondrial injury and lung inflammation. Free Radical Biology and Medicine 85:83-94 PMCID:PMC4508227

88. Rangarajan S, Kurundkar A, Kurundkar D, Bernard K, Sanders Y, Ding Q, Antony VB, Zhang J, Zmijewski J, Thannickal VJ (2016) Novel mechanisms for the anti-fibrotic action of Nintedanib. American Journal of Respiratory Cell and Molecular Biology (AJRCMB) 54:51-59 PMCID: PMC4742925

89. Klionsky et al (Zhang J as one of ~2000 co-authors) (2016) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 12:1, 1-222 PMCID:PMC4835977

90. Radhakrishnan RK, Narasimhan M, Shanmugam G, Devarajan A, Palaniappan S, Zhang J, Halade G, Darley-Usmar VM, Hoidal JR, Rajasekaran NS (2016) Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-Intensity exercise stress. Journal of Translational Medicine 14:86 PMCID:PMC4822244

91. Redmann M, Darley-Usmar V, Zhang J (2016) The role of autophagy, mitophagy and lysosomal functions in modulating cellular bioenergetics and survival in the context of redox and proteotoxic damage: implications for age dependent neurodegenerative diseases. Aging and Disease 7:150-162 PMCID:PMC4809607

92. Hjelmeland A, Zhang J (2016) Metabolic, autophagic and mitophagic activities in cancer initiation and progression. Biomedical Journal 39:98-106 PMCID:PMC5514543

93. Wende AR, Young M, Chatham J, Zhang J, Rajasekaran NS, Darley-Usmar VM (2016) Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism. Free Radical Biology and Medicine 100:94-107PMCID:PMC5124549

94. Aggarwal S, Mannam P, Zhang J (2016) Autophagy and mitophagy in pulmonary diseases. Am J of Physiol Lung Cell Mol Physiol 311:L433-L452. PMCID:PMC5504426

95. Wani W, Chatham J, Darley-Usmar V, McMahon L, Zhang J (2017) O-GlcNAcylation and neurodegeneration. Brain Res Bulletin 133:80-87 PMCID:PMC5292095

96. Redmann M, Benavides GA, Berryhill TF, Wani WY, Ouyang X, Johnson MS, Ravi S, Barnes S, Darley-Usmar VM, Zhang J (2017) Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons. Redox Biology 11:73-81 PMCID:PMC5124357

97. Redmann M, Wani W, Volpicelli-Daley L, Darley-Usmar V, Zhang J (2017) Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils. Redox Biology 11:429-437 PMCID:PMC5220183

98. Bernard K, Logsdon NJ, Herranz VM, Benavides GA, Zhang J, Darley-Usmar VM, Thannickal VJ (2017) NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis in Lung Fibroblasts via a Nuclear Factor Erythroid- Derived 2-like 2 (Nrf2)-Dependent Pathway. J Biol Chem 292:3029-3038 PMCID:PMC5314196

99. Cheng S, Wani WY, Hottman DA, Jeong A, Cao D, LeBlanc KJ, Saftig P, Zhang J*, Li L* (2017) Haplodeficiency of Cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice. J Neurochem 142(2):297-304 *Co-corresponding author PMCID:PMC5499660

100. Parakh VV, Pabbisetty SK, Wu L, Sebzda E, Martinez J, Zhang J, Van Kaer L (2017) The autophagy-related protein Vps34 controls the homeostasis and function of antigen cross-presenting CD8α+ dendritic cells. Proc Nat Acad Sci USA 114(31):E6371-E6380. PMCID:PMC5547642

101. Wani WY, Ouyang X, Benavides GA, Redmann M, Cofield JS, Shacka JJ, Darley-Usmar V, Chatham JC, Zhang J (2017) O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson's disease. Molecular Brain 10:32 PMCID:PMC5517830

102. McGinnis GR, Tang Y, Brewer R, Brahma M, Stanley HL, Shanmugam G, Rajasekaran NS, Row GC, Frank SJ, Wende AR, Abel ED, Taegtmeyer H, Litovsky S, Darley-Usmar V, Zhang J, Chatham JC, Young ME (2017) Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart. Journal of Molecular and Cellular Cardiology 110:80-95 PMCID:PMC5586500

103. Wu P, Yuan X, Li F, Zhang J, Zhu W, Wei M, Li J, Wang X (2017) Myocardial upregulation of cathepsin D by ischemic heart disease promotes autophagic flux and protects against cardiac remodeling and heart failure. Circ Heart Fail 10:e004044 PMCID:PMC5535800

104. Dodson M, Benavides G, Johnson M, Redmann M, Wani WY, Ouyang X, Cofield SS, Mitra K, Darley-Usmar V, Zhang J (2017) Regulation of autophagy, mitochondrial dynamics and cellular bioenergetics by 4-hydroxynonenal in primary neurons. Autophagy 13(11):1828-1840 PMCID:PMC5788494

105. Nelson M, Boutin M, Tse T, Lu H, Haley EM, Ouyang X, Zhang J, Auray-Blais C, Shacka JJ (2017) The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson’s disease brain in association with the pathologic accumulation of alpha-synuclein. Neurobiology of Disease 110:68-81 PMCID:PMC5747987

106. Bernard K, Logsdon NJ, Benavides GA, Sanders Y, Zhang J, Darley-Usmar VM, Thannickal VJ (2018) Glutaminolysis is required for TGF-β1-induced myofibroblast differentiation and activation. J Biol Chem 293(4):1218-1228 PMCID:PMC5787800 (IF4)

107. Brewer RA, Collins HE, Berry RD, Brahma MK, Tirado B, Stanley HL, Wende AR, Taegtmeyer H, Rajasekaran NS, Darley-Usmar V, Zhang J, Frank SJ, Chatham JC, Young ME (2018) Temporal partitioning of adaptive responses of the murine heart to fasting: a guide for experimental design. Life Sciences 197:30-39 PMCID:PMC5837814 (IF3.2)

108. *Zhang J, Culp ML, Craver JG, Darley-Usmar V (2018) Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson’s disease. *corresponding author. J Neurochem 144(6):691-709, PMCID:PMC5897151 (IF4.6)

109. Redmann M, Benavides BA, Wani WY, Berryhill TF, Ouyang X, Johnson MS, Ravi R, Mitra K, Barnes S, Darley-Usmar VM, Zhang J (2018) Methods for assessing mitochondrial quality control mechanisms and cellular consequences in cell culture. Redox Biology 17, 59-69 PMCID:PMC6006680 (IF7.2)

110. Hough KP, Trevor JL, Strenkowski JG, Wang Y, Chacko BK, Tousif S, Chanda D, Steele C, Antony VB, Dokeland T, Ouyang X, Zhang J, Duncan SR, Thannickal VK, Darley-Usmar VM, Deshane JS (2018) Exosomal Transfer of Mitochondria from Airway Myeloid-Derived Regulatory Cells to T cells. Redox Biology 18:54-64 PMCID:PMC6031096 (IF7.2)

111. Libby CJ, Zhang S, Benavides GA, Scott SE, Li Y, Redmann M, Tran AN, Otamias A, Darley-Usmar V, Napieralo M, Zhang J, Augelli-Szafran CE, Zhang W, Hjelmeland A (2018) Identification of Compounds That Decrease Glioblastoma Growth and Glucose Uptake in Vitro. ACS Chemical Biology 13 (8), pp 2048–2057 PMCID:PMC6425477 (IF4.6)

112. Wright JN, Benavides GA, Johnson MS, Wani W, Ouyang X, Zou L, Collins H, Zhang J, Darley-Usmar V, Chatham JC (2019) The effect of short durations of increased cellular O-GlcNAc levels on mitochondrial function. AJP-Cell Phys (IF3.5)

113. Hill BG, Shiva S, Ballinger B, Zhang J, Darley-Usmar V (2019) Bioenergetics and translational metabolism: Implications for physiology and precision medicine. Biol Chem (IF3)

114. Zhang J, Chatham JC, Young M (2019) Circadian regulation of cardiac biology: rhythms that keep the heart beating. Annual Review of Physiology (IF14)

EDITORIALS:

115. Zhang J (2015) Autophagy Virtual collection Vol 1 Redox Biology 116. Zhang J, Darley-Usmar V (2017) Autophagy and the redox connection: Virtual collection Vol

2 Redox Biology 11:620-621 117. Zhang J, Van Remmen (2017) Redox biology in neurodegenerative disease – Virtual

collection. Redox Biology 118. Zhang J, Butterfield DA (2017) Oxidative stress and neurodegeneration. Brain Research

Bulletin. 133:1-3 BOOKS AND BOOK CHAPTERS:

119. Zhang J, Walsh R, Xu M (2000) Probing the role of the dopamine D1 receptor in

psychostimulant addiction. Annals of New York Academy of Sciences, SF Ali and Y Takahashi, eds. (New York: The New York Academy of Sciences) 914:13-21

120. Zhang J, Zhang D, Xu M (2002) Identification of target genes regulated by repeated cocaine exposure through the DA D1 receptor using cDNA microarrays. Annals of New York Academy of Sciences, SF Ali and Y Takahashi, eds. (New York: The New York Academy of Sciences). 965:1-9

121. Xu M, Zhang J (2003) DNA fragmentation in apoptosis and tissue homeostasis. Molecular Mechanisms of Programmed Cell Death, Y Shi, eds. (Kluwer Academic) pp 171-184

122. Zhang J, Xu M (2003). Generating gene knockout mice for studying mechanisms underlying drug addiction. Methods in Molecular Medicine J Wang, eds. (Humana Press) 79:351-363

123. Gulbahar H. Beckett and Jianhua Zhang (2006) Moderation, Modesty, Creativity, and Criticalness: A Chinese-American Medical Professor Speaks. "Strangers" of the Academy Asian Women Scholars in Higher Education, G Li and GH Beckett, eds. (Stylus Publishing, LLC) pp 233-248

124. Jegga AG, Kong S, Zhang J, Moseley A, Gupta A, Williams SS, Genter MB, Aronow BJ (2006) Comparative genomics of tissue specific gene expression. Gene Expression and Regulation, A Current Scientific Frontiers Book, J Ma, eds. (Higher Education Press and Springer, USA) pp 393-408

125. Zhang J, Zong W-X (2006) Cell death and transcription. Gene Expression and Regulation, A Current Scientific Frontiers Book, J Ma, eds. (Higher Education Press and Springer, USA) pp 421-432

126. Zhang J, Xu M (2006) Opposite regulation of cocaine-induced intracellular signaling and gene expression by dopamine D1 and D3 receptors. Annals of New York Academy of Sciences, SF Ali and Y Takahashi, eds. (New York: The New York Academy of Sciences) 1074:1-12

127. Liang Q, Zhang J (2009) Apoptosis in neurodegenerative diseases. “Essential of Apoptosis”, 2nd edition, XM Yin and Z Dong, eds. pp 489-504

128. Zhang J, Darley-Usmar VM (2012) Mitochondrial dysfunction in neurodegenerative disease; protein aggregation, autophagy and oxidative stress. Mitochondrial Dysfunction in Neurodegenerative Disorders, AJ Reeve, KJ Krishnan, MR Duchen, DM Turnbull, eds. (Springer) pp95-112

129. Zelickson BR, Ballinger S, Dell’Italia L, Zhang J, Darley-Usmar VM (2013) Reactive Oxygen and Nitrogen Species; Interactions with Mitochondria and Pathophysiology. The Encyclopedia of Biological Chemistry, WJ Lennarz, MD Lane, (eds.) Vol. 4, pp. 167-171. Waltham, MA: Academic Press.

130. Hervouet E, Zhang J, Boyer-Guittaut (2015) ROS and epigenetics. Reactive oxygen species, pp519-533, Ahmad S (eds.) Taylor and Francis.