Curriculum Vitae

Professor of Pharmacology

University of Colorado Health Science Center Biographical Sketch

Name: Richard Adam Deitrich

Business Address:

University of Colorado School of Medicine Department of Pharmacology 4200 East Ninth Avenue, Box C236 Denver, Colorado 80262 USA e-mail: Richard.Deitrich@UCHSC.edu

Educational Record:

Military Service:

1949-1953 B.S., University of Colorado School of Pharmacy

1953-1954 M.S., University of Colorado School of Pharmacy

1956-1959 Ph.D., University of Colorado Health Sciences Center, Department of Pharmacology

1959-1961 Postdoctoral Fellow (Dr. Leslie Hellerman) The Johns Hopkins School of Medicine Department of Physiological Chemistry

1954-1956 U.S. Army, Army Medical Nutrition Laboratory

Professional Experience: 1961-1963 Instructor, The Johns Hopkins School of Medicine,

Department of Physiological Chemistry

1963-1969 Assistant Professor, University of Colorado School of Medicine, Department of Pharmacology

1969-1976 Associate Professor of Pharmacology, University of Colorado School of Medicine, Department of Pharmacology

1973-1974 Visiting Professor, University of Bern, Bern,

Switzerland

1975-Present Faculty Research Associate, Institute for Behavioral Genetics, University of Colorado

1975-2001 Vice Chairman of Pharmacology, University of Colorado School of Medicine

1976-Present Professor of Pharmacology, University of Colorado School of Medicine

1976 Acting Chairman of Pharmacology, University of Colorado School of Medicine

1977-2003 Scientific Director/ Principal Investigator, University of Colorado National Alcohol Research Center

1983-1984 Acting Chairman, Department of Pharmacology, University of Colorado School of Medicine

1985-1986 Acting Chairman, Department of Pharmacology, University of Colorado School of Medicine

Research Interests:

Metabolism of aldehydes, mainly in relation to mechanism of addiction to ethanol and other sedatives

Genetics of alcohol action Genetic control of enzyme induction Biochemical genetics of behavior as related to drug effects

Teaching Experience: University of Colorado Medical Center - Principles of

Pharmacology, medical, graduate students 1963-2001 Alcoholism in Society, medical students staarted 1971

Ethics in Research

Enzyme Kinetics, graduate students started1967

Drug Metabolism, graduate students started 1974

Johns Hopkins School of Medicine - Physiological Chemistry Laboratory four years

University of Arizona (visiting) - Pharmacology, medical students

Colorado State University (visiting) - Enzymes of Alcohol Metabolism

University of California-Berkeley (visiting) - Pharmacology

Ph.D. Students Postdoctoral Students Visiting Professors

V. Gene Erwin Howard Robbins Dr. O. Tottmar (Sweden)

Richard J. Kraemer Alan Collins Dr. P. Eriksson Finland)

Chakwan Siew Michael Roper Dr. J.-F. Menez (France) Victoria Simpson David Farrier Dr. J. Ewing (Univ. N.C.) Charles Duncan Dr. S. Zimatkin (Belarus) Christine Melchior Dr. Abdulov (Russia) Herbert Markley Dr. A. Kibitov (Russia)

Laura Draski Dr. Philippe DeWitte (Belgium)

Yong Liu Dr. Aragon (Canada/Spain) Kathryn Gill Karen Spuhler Jacques Maring Wendy Keir

M.S. Students: Ebony Parker Honors:

1949-1953 Joint Honor Scholarship

1956-1959 American Foundation for Pharmaceutical Education Predoctoral Fellowship

1959-1961 National Heart Institute, Postdoctoral Fellowship 1963-1965 Lederle Medical Faculty Award 1969 Fellow of the American Institute of Chemists

1965-1975 Research Career Development Award, National Institute of General Medical Science

1978 Kaiser Permanente Teaching Award 1981-1983 President, Research Society on Alcoholism

1984 Research Excellence Award, Research Society on Alcoholism

1986-2001 Research Scientist Award, Nat. Inst. Alcohol Abuse and Alcoholism

1991 Distinguished Coloradan Award, School of Pharmacy, University of Colorado

1991 Faculty Council Award, University of Colorado 1997 Sexias Award, Research Society on Alcoholism 1995-2003 MERIT award NIAAA 2002 Mark Keller Lecture, NIAAA

Committees & Editorial

Boards:1971-1977

Committee on Standards for Biological Compounds, National Research Council Subcommittee on Biogenic Amines

1970 Delegate to U.S.P. Convention

1977-1982 NIAAA Study Section

1977-1979 Member, Publication Committee - Research Society on Alcoholism

1979-1981 Chairman, Publication Committee - Research Society on alcoholism

1979-1981 Chairman, Public Policy Committee -Research Society on Alcoholism

1979-1981 President Elect - Research Society on Alcoholism

1979 Steering Committee of the International Society for Biomedical Research on Alcoholism

1981-1983 President - Research Society on Alcoholism

1982-1984 Chairman, Meeting Organizing Committee, International Society for Biomedical Research on Alcoholism

1983-1985 Past President - Research Society on Alcoholism 1983-1987 VA Merit Review Board 1984-1987 Chairman, VA Merit Review Board 1985-1987 Membership Chairman, Res. Soc. Alcoholism 1986-1996 Treasurer, Int. Soc. Biomed. Res. on Alcoholism 1986-1990 Board of Scientific Counselors, NIAAA 1987-1990 Chairman, Board of Scientific Counselors, NIAAA

1990-1991 Board of Division of Biobehavioral Sciences and Mental Disorders Institute of Medicine

2000-2003 Member Advisory Council, NIAAA

Professional Memberships

:

• American Association for the Advancement of Science • Sigma Xi. • Rho Chi Pharmacy Honorary Society • American Chemical Society • American Society for Pharmacology and Experimental Therapeutics • American Society for Neurochemistry • American Society for Biological Chemistry and Molecular Biology • Research Society on Alcoholism • International Society for Biomedical Research on Alcoholism

Grant Support:

Research Grant Support: (Continuously supported since 1963)

Active Support NIAAA Rats Selectively Bred for Sensitivity to Ethanol. 07/01/04-06/30/08. . RO1 Award

Pending Grant: 1R21 AA 12284-01 Role of acetaldehyde in central actions of ethanol. 7/1/99-6/30/01. $140,000. With Dr. Sergey Zimatkin, Grodno, Belarus FSU

Previous Support:

National Institute of Neurological, Communicative Diseases and Stroke and National Institute on Alcoholism and Alcohol Abuse continuously since 1963

National Council on Alcoholism Insurance Institute of America Licensed Beverage Dealers National Institute of General Medical Science

Civilian Research and Development Foundation grant for work with Dr. S. Zimatkin, Grodno, Belarus.

Training Grant Support:

National Institute on Alcohol Abuse and Alcoholism and National Institute on Drug Abuse - Postdoctoral

National Institute of General Medical Sciences, Predoctoral – Research Preceptor (Active),

Current Editorial Activities:

Assoc. Editor - Current Developments in Alcoholism

Editorial Boards: Alcohol and Alcoholism

Brazilian Journal of Genetics Previous Editorial

Committees:

Alcohol (resigned)

Life Sciences (Ended 1993)

Associate editor. Journal of Studies on Alcohol 1986-2002

Alcohol Health and Research World (Ended 1993)

Editor - Alcohol and Drug Research (Ended)

Associate Editor: Alcoholism: Clinical and Experimental Research (Ended 1999)

University Committees:

1978-1979

President of the Faculty Senate, University of Colorado Medical School

1976-1977 Planning and Fiscal Policy Committee

1974-1977 Admissions Committee - Medical School

1972-1973 Faculty Council of the Senate

1980- Faculty Council of the Senate

1984 1972-1973 Faculty Council of the Medical Center

1971-1972 Chairman, Radiation Safety Committee

1971-1973 Education Resources Committee, Medical Center

1990- Institutional Animal Care and Use Committee Chairman, 1994-1999

1994 Committee on Departmental Reviews 1965-1975

Graduate Advisor: Department of Pharmacology

Ad hoc Committee: Departmental Status for Division of Biometrics, and Orthopaedic Surgery

Ad hoc Committees for Promotion

Ad hoc Committees for Chairpersons of Microbiology, Anatomy and Chairman of committee for Physiology Chair.

Curriculum and Promotions Committee I & II and III & IV

School of Medicine Space Committee

LCME Accreditation Committee 1990-1991 Salary Equity Review

2000-present Privilege and Tenure Committee

Community

Service:Member - Board of Directors of National Council on Alcoholism - Mile High Area 1966-1981 (President, 1972-1973).

Member - Board of Directors, National Council on Alcoholism, 1981-1982

Moderator - First Universalist Church of Denver, 1969

City and County of Denver Grand Jury 2001 Invited

Seminars:University of Alabama

University of California - Berkley

University of North Carolina

University of Florida

Medical University of South Carolina

University of South Carolina

University of Arizona

Colorado State University

Ft. Lewis College

Purdue University

University of New Mexico

University of Cologne, Germany

University of Strasbourg, France

University of Bern, Switzerland

ALKO, Helsinki, Finland

University of Mississippi

Massey University, Palmerston North, New Zealand

University of Mississippi School of Medicine

Grambling State University

Invited Foreign Meetings

BAR meeting. Scandinavian Alcohol Research. Stockholm, Sweden

ISBRA Congresses, Germany, USA (organizer), Japan, England, Canada, Finland, Australia

IUPHAR Sydney, Australia

Australian Drug and Alcohol Meeting, Brisbane, Australia

Institute of Narcology, Moscow, Russia

Genetics of Alcoholism, Bordeaux, France.

Book Chapters, Reviews and Proceedings:

1. Deitrich, R.A.: Effect of in vivo administration of disulfiram, cyanamide and metronidazole on rabbit liver aldehyde oxidation. Proc. Western Pharmacol. Soc. 10:19-22 (1967)

2. Deitrich, R.A.: Genetic basis of phenobarbital-induced increase in aldehyde dehydrogenase:Implications for alcohol research. Ann. N.Y. Acad. Sci. 197:73-78 (1972).

3. Deitrich, R.A. and Siew, C.: Localization and function of aldehyde dehydrogenase. Thurman, R.G. et al., Alcohol and Aldehyde Metabolizing Systems, Academic Press, N.Y. 125-135 (1974).

4. Deitrich, R.A.: Neurochemistry of Ethanol: Introduction. Fed. Proc. 34:1929 (1975).

5. Deitrich, R.A. and Erwin, V.G.: Role of biogenic amine metabolism in ethanol addiction. Fed. Proc. 34:1962-1968 (1975) Symposium.

6. Deitrich, R.A.: Biochemical aspects of alcoholism: Psychoneuroendocrinology 1:325-346 (1976).

7. Deitrich, R.A.: Plasmalogen content of cerebellum samples from alcoholic and non-alcoholic humans. Alcoholism, Clinical and Research Studies 1:57-59 (1977).

8. Deitrich, R.A. and Collins, A.C.: Pharmacogenetics of alcoholism. In: Neurochemical and Behavioral Mechanisms of Alcohol and Opiate Dependence, Eds. Blum, K. and Ross, D., Academy Press, N.Y. (1977) pp. 109-139.

9. Deitrich, R.A.: Aldehyde metabolism and biogenic amines. In: Biochemistry and Function of Monoamine Enzymes. Eds. Usdin, E. and Weiner, N. Marcel-Dekker, N.Y., (1977) pp. 651-674.

10. Petersen, D.R., Collins, A.C. and Deitrich, R.A.: Induction of cytosolic aldehyde dehydrogenase isozymes: Influence of acetaldehyde metabolism. In: Alcohol and Aldehyde Metabolizing Systems, Vol. II. Eds. Thurman, R.G., et al., Academic Press, N.Y., (1977) pp. 223-234.

11. Deitrich, R.A. and Petersen, D.R.: Interaction of ethanol with other drugs. In: Biochemistry and Pharmacology of Ethanol. Vol. II. Eds. Majchrowicz, E. and Noble, E., Plenum Press, N.Y., (1979) pp. 283-302.

12. Deitrich, R.A.: Overview of biomedical developments. In: Currents in Alcoholism Biomedical Issues and Clinical Effects of Alcoholism. Vol. 5, Ed. Galanter, M., Grune and Stratton, Inc. N.Y. (1979) pp. 1-2.

13. Deitrich, R.A.: Introduction to mechanism of addiction. In: Currents in Alcoholism Biomedical Issues and Clinical Effects of Alcoholism. Vol. 5, Ed. Galanter, M., Grune and Stratton, Inc. N.Y. (1979) pp. 3-4.

14. Deitrich, R.A.: Introduction to physiological effects of ethanol.

In: Currents in Alcoholism Biomedical Issues and Clinical Effects of Alcoholism. Vol. 5, Ed. Galanter, M., Grune and Stratton, Inc. N.Y. (1979) pp. 61-62.

15. Deitrich, R.A.: Introduction to altering ethanol effects. In: Currents in Alcoholism Biomedical Issues and Clinical Effects of Alcoholism. Vol. 5, Ed. Galanter, M., Grune and Stratton, Inc. N.Y. (1979) pp. 163-164.

16. Deitrich, R.A. and Erwin, V.G.: Biogenic amine-aldehyde condensation products tetrahydroisoquinolines and tryptolines (B-carbolines). Ann. Rev. Pharmacol. Toxicol. 20:55-80 (1980).

17. Tabakoff, B., Ritzmann, R., Raju, T.S. and Deitrich, R.A.: Characterization of acute and chronic tolerance in mice selected for inherent differences in sensitivity to ethanol. Alc.: Clin. and Exper. Res. 4:70-73 (1980).

18. Melchior, C.L. and Deitrich, R.A.: Half-lives and actions of intracerebrally injected isoquinolines. Adv. Exp. Med. Biol. 126:121-129 (1980).

19. Deitrich, R.A. and McClearn, G.E.: Neurobiological and genetic aspects of the etiology of alcoholism. Federation Proc. 40:2051-2055 (1981).

20. Eriksson, C.J.P. and Deitrich, R.A.: Evidence against a biphasic effect of acetaldehyde on voluntary ethanol consumption in rats. Pharmacol. Biochem. Behav. 13: Suppl. 1, 291-296 (1981).

21. Deitrich, R.A.: Alcohol as a precursor or modulator of neuroactive agents. Alcoholism, Clin. and Exp. Res. 5:455 (1981).

22. McClearn, G.E., Deitrich, R.A. and Erwin, V.G. (eds). Development of Animal Models as Pharmacogenetic Tools. Research Monograph #6, National Institute on Alcohol Abuse and Alcoholism, DHHS Publication No (ADM) 81-113 (1981).

23. Eriksson, C.J.P., Deitrich, R.A., Rusi, M., Clay, K. and Petersen, D.A.: Dissociation of components of ethanol tolerance and dependence. Advances in Pharm. Ther. II 5:245-251 (1982).

24. Plomin, R. and Deitrich, R.A.: Neuropharmacogenetics and behavioral genetics. Behav. Genet. 12:111-121 (1982).

25. Eriksson, C.J.P. and Deitrich, R.A.: Metabolic mechanisms in tolerance and physical dependence on alcohol. Vol. 7, The Biology of Alcoholism. Eds. Kissin, B. and Begleiter, H. Plenum Press, N.Y., pp. 253-283 (1983).

26. Deitrich, R.A. and Petersen, D.R.: Interaction of ethanol with other drugs. In Medical and Social Aspects of Alcohol Abuse. Ed. Tabakoff, B., Sutker, P.B. and Randall, C.L., Plenum Press, N.Y., pp. 247-272 (1983).

27. Deitrich, R.A.: Hepatic subcellular localization of aldehyde dehydrogenase. In: Biological Approach to Alcoholism. Ed., Lieber, C.S. NIAAA Research Monograph II DHHS Pub. #

ADM 83-1261, pp. 318-322 (1983). 28. Petersen, D.R., Erwin, V.G. and Deitrich, R.A.: Brain

acetaldehyde metabolism during ethanol consumption. In: Biological/Genetic Factors in Alcoholism. Eds. Hesselbrock, V.M., Shaskan, E.G. and Meyer, R.E. NIAAA Research Monograph #9 DHHS Pub. # ADM 83-1199, pp. 93-100 (1983).

29. Deitrich, R.A. and Spuhler, K.: Genetics of alcoholism and alcohol actions. In: Research Advances in Alcohol and Drug Problems, Vol. 8. Ed., Smart, Cappell, Glaser, Israel, Kalant, Schmidt and Sellers, Plenum Publishing Corp., pp. 47-98, (1984).

30. Deitrich, R.A. and Erwin, V.G.: Interaction of amine metabolism and alcohol actions. In: Monoamine Oxidase and Disease (Editors, K.F. Tipton, P. Dostert and M.S. Benedetti), Academic Press, New York, pp. 275-289 (1984).

31. Deitrich, R.A. and Baker, R.C.: Critical laboratory questions. In: Pharmacological Treatments for Alcoholism. Ed., G. Edwards and J. Littleton, Croom Helm, Ltd, London, pp. 13-24, (1984).

32. Deitrich, R.A. and Baker, R.C.: Initial sensitivity of rat inbred strains to acute alcohol. Symposium Series: The development of a rat model for pharmacogenetic research in alcoholism. In: Alcoholism: Clin. Exp. Res. 8:487-490 (1984).

33. Spuhler, K.P. and Deitrich, R.A.: Correlative analysis of ethanol-related phenotypes in rat inbred strains. Symposium Series: the development of a rat model for pharmacogenetic research in alcoholism. In: Alcoholism: Clin. Exp. Res. 8:480-484 (1984).

34. Deitrich, R.A.: Alcohol Research Comes of Age. Alcoholism: Clin. Exp. Res. 8:511-512 (1984) (editorial).

35. Deitrich, R.A. and Melchior, C.L.: A critical assessment of animal models for testing new drugs for altering ethanol intake. In: Research Advances in New Psychopharmacological Treatments for Alcoholism (Editors, C.A. Naranjo and E.M. Sellers), Excerpta Medica, Amsterdam, pp. 23-41 (1985).

36. Deitrich, R.A.: Review of "dual addiction": Pharmacological issues in the treatment of concomitant alcoholism and drug abuse. In: J. Stud. Alc. (Editors, Stimmel, B. and Kreek, M.J.), 46:174 (1985).

37. Schuckit, M.A., Li, T.-K., Cloninger, C.R. and Deitrich, R.A.: Genetics of alcoholism. Alcoholism: Clin. Exp. Res. 9, 475-492 (1985).

38. Deitrich, R.A., and Erwin, V.G., The Drinker's tail. Animal Genetics in Alcohol Research. Alcohol Health and Research World: 12, 98-101, (1987).

39. Deitrich, R.A., Ethyl Alcohol (Monograph for a Drug Compendium) , (1987).

40. Deitrich, R.A., Genetics of alcoholism: An overview. Australian

Drug & Alcohol Review 7:5-7 (1988). 41. Deitrich, R.A., Use of selective breeding in alcohol research.

Australian Drug & Alcohol Review 7:13-15 (1988). 42. Deitrich, R.A., Spuhler, K.P., Baker, R.C. and Erwin, V.G.,

Development and characteristics of rats selectively bred for sensitivity to ethanol. In: Biomedical and Social Aspects of Alcohol and Alcoholism, K. Kuriyama, A. Takada and H. Ishii, eds., Elsevier Science Publishers, B.V., pp. 419-422, (1988).

43. Keir, W.J., Deitrich, R.A. and Sikela, J., Sequence comparison of the GABAA receptor ˜1 subunit cDNA in long- and short-sleep mice by direct sequencing of polymerase chain reaction amplified cDNA. N.Y. Acad. Sci., (1988)

44. Deitrich, R.A., Dunwiddie, T.V., Harris, R.A. and Erwin, V.G., Mechanism of action of ethanol: Initial central nervous system actions. Pharmacol. Rev. 41:489-537, (1989).

45. Deitrich, R.A., Selective breeding of mice and rats for initial sensitivity to ethanol: Contributions to understanding ethanol's action. In Deitrich, R.A., ed. Conference on Initial Effects of Ethanol, NIAAA Monograph, #20, (1990).

46. Deitrich, R.A. and Pawlowski, A., Eds., Conference on Initial Effects of Ethanol. NIAAA Monograph, #20, (1990).

47. Spuhler, K., Deitrich, R.A. and Baker, R.C., Selective breeding of rats differing in sensitivity to the hypnotic effects of acute ethanol administration. In Deitrich, R.A. ed. Conference on Initial Effects of Ethanol, NIAAA Monograph, #20, (1990).

48. Deitrich R.A., Selective breeding for initial sensitivity to ethanol. Behavior Genetics 23, 153-162, (1993).

49. Deitrich, R.A. and Palmer, J.D., Alcohol. In: Human Pharmacology, Molecular-To-Clinical, eds. Wingard, L.B., Brody, T.M., Larner, J. and Schwartz, A., Mosby Year Book, Inc. 1994, pp. 423-434. 3rd. ed.

50. Deitrich, R.A., and Baker, R.C., Genetic influences on alcohol metabolism and sensitivity to alcohol in animals. in Begleiter, H., and Kissin, B., The Genetics of Alcoholism. pp 139-164. Oxford University Press New York, (1995).

51. Deitrich, R.A., Radcliffe, R., and Erwin, V.G., Pharmacological Effects in the Development of Tolerance and Physical Dependence. In Begleiter, H., and Kissin, B., The Biology of Alcoholism, (1995).

52. Deitrich, R.A., and Erwin, V.G., Eds. Pharmacological Effects of Ethanol on the Nervous System. CRC press. Boca Raton, Fl. 528.(1995)

53. Deitrich, R.A., Radcliffe, R., and Erwin, V.G., Pharmacological effects in the development of tolerance and physical dependence. In Begleiter, H., and Kissin, B., Eds. in "The Pharmacology of Alcohol and Alcohol Dependence, Oxford University Press New

York, pp 431-476, (1996). 54. Deitrich, R.A. and Harris R.A., How much alcohol should I use

in my experiments? Alcoholism: clinical and Experimental research (editorial) 20: 1, 1(996).

55. Zimatkin, S., and Deitrich, R.A., Ethanol metabolism in the brain. Addiction Biology 2: 387-399, (1997).

56. Zimatkin, S.M., Liopo, A.V. and Deitrich, R.A., Oxidation of ethanol to acetaldehyde in brain and the possible behavioral consequences. In: Enzymology and Molecular biology of Carbonyl Metabolism 7, Eds Weiner, et al, Kluwer Academic/Plenum Publishers, New York, pp. 231-236, 1999.

57. Zimatkin, S.M., Liopo, A.V., Deitrich, R.A., Oxidation of ethanol to acetaldehyde in brain and the possible behaviroral consequences. Adv Exp Med Biol. 463 (231-6 (1999)

58. McBride, W.J., Li, T.K., Deitrich, R.A., Zimatkin, S, Smith, B.R., Rodd-Henrichs, Z.A., Involvement of acetaldehyde in alcohol addiction. Alcohol Clin Exp Res. , Jan., 26(1) 114-9 (2002)

59. Deitrich, R.A., Acetaldehyde, de ja vu, du jour. Journal of Studies on Alcohol In Press

Papers in Refereed Journals:

1. Heim, H.C., Deitrich, R.A. and McDonald, J.G.: The effect of hydrocortisone on the oxygen uptake of inflamed tissue. J. Pharmacol. Exp. Ther. 114:51-53 (1955).

2. Deitrich, R.A. and Heim, H.C.: The effect of emetine upon rat heart respiration. J. Am. Pharm. Assoc. (Scientific Edition) 14:562-563 (1956).

3. Deitrich, R. and Smith, D.L.: Effect of the thyroid on butyrate oxidation in the rat heart. Biochem. Pharm. 3:85-88 (1960).

4. Deitrich, R.A., Hellerman, L. and Wean, J.: Diphosphopyridine nucleotide-linked aldehyde dehydrogenase. I. Specificity and Sigma Rho function. J. Biol. Chem. 237:560-564 (1962).

5. Deitrich, R.A. and Hellerman, L.: Diphosphopyridine and nucleotide-linked liver aldehyde dehydrogenase. II. Inhibitors. J. Biol. Chem. 238:1683-1689 (1963).

6. Deitrich, R.A. and Hellerman, L.: Pyruvate metabolism. V. Pyruvate utilization by mitochondria of rat brain. J. Biol. Chem. 238:2735-2740 (1964).

7. Deitrich, R.A.: Tissue and subcellular localization of mammalian aldehyde oxidizing capacity. Biochem. Pharmacol. 15:1911-1922 (1966).

8. Erwin, V.G. and Deitrich, R.A.: Brain aldehyde dehydrogenase localization, purification and properties. J. Biol. Chem. 241:3533-3539 (1966).

9. Deitrich, R.A.: Diphosphopyridine nucleotide-linked aldehyde dehydrogenase. III. Sulfhydryl characteristics of the enzyme. Arch. Biochem. Biophys. 119:253-263 (1967).

10. Kraemer, R.J. and Deitrich, R.A.: Isolation and characterization of human liver aldehyde dehydrogenase. J. Biol. Chem. 243:6402-6408 (1968).

11. Deitrich, R.A. and Erwin, V.G.: A convenient spectrophotometric assay of monoamine oxidase. Anal. Biochem. 30:395-402 (1969).

12. Erwin, V.G. and Deitrich, R.A.: The labeling in vivo of monoamine oxidase by 14C-pargyline: A tool for studying the synthesis of the enzyme. Molec. Pharmacol. 7:219-228 (1971).

13. Rutledge, C.O, and Deitrich, R.A.: Inhibition of aldehyde dehydrogenase by 2-chloracetophenone and the resultant effects on the catabolism of norepinephrine in the brain. Biochem. Pharmacol. 20:193-201 (1971).

14. Deitrich, R.A. and Erwin, V.G.: Mechanism of the in vivo inhibition of aldehyde dehydrogenase by disulfiram and diethyldithiocarbamate. Molec. Pharmacol. 7:301-307 (1971).

15. Deitrich, R.A.: Genetic aspects of increase in rat liver aldehyde dehydrogenase induced by phenobarbital. Science 173:334-336 (1971). Deitrich, R.A., Collins, A.C. and Erwin, V.G.: Effect of pyrazole in vivo on aldehyde metabolism in rat liver and brain. Biochem. Pharmacol. 20:2663-2669 (1971).

16. Deitrich, R.A., Collins, A.C. and Erwin, V.G.: Effect of pyrazole in vivo on aldehyde metabolism in rat liver and brain. Biochem. Pharmacol. 20:2663-2669 (1971).

17. Erwin, V.G. and Deitrich, R.A.: Heterogeneity of alcohol dehydrogenase enzymes in various tissues. Biochem. Pharm. 21:2915-2924 (1972).

18. Deitrich, R.A., Collins, A.C. and Erwin, V.G.: Genetic influence upon phenobarbital-induced increase in rat liver supernatant aldehyde dehydrogenase activity. J. Biol. Chem. 247:7232-7236 (1972).

19. Ellis, P.P., Littlejohn, D. and Deitrich, R.A.: Enzymatic hydrolysis of pilocarpine. Invest. Ophthalmology 11:747-751 (1972).

20. Erwin, V.G. and Deitrich, R.A.: Inhibition of bovine brain aldehyde reductase by anticonvulsant compounds in vitro. Biochem. Pharmacol. 22:2615-2624 (1973).

21. Deitrich, R.A., Troxell, P.A. and Erwin, V.G.: Characteristics of aldehyde dehydrogenase in rat liver. Arch. Biochem. Biophys. 166:543-548 (1975).

22. Ris, M.M., Deitrich, R.A. and von Wartburg, J. -P.: Inhibition studies with aldehyde reductase from rat brain. Biochem. Pharmacol. 24:1865-1969 (1975).

23. Siew, C.S., Deitrich, R.A. and Erwin, V.G.: Submitochondrial localization of liver aldehyde dehydrogenase. Arch. Biochem. Biophys. 176:683-689 (1976).

24. Erwin, V.G., Heston, W.D.W., McClearn, G.E. and Deitrich, R.A.: Effect hypnotic agents on mice with differing central nervous system sensitivity to ethanol. Pharm. Biochem. Behav. 4:679-683 (1976).

25. Deitrich, R.A., Erwin, V.G., Troxell, P.A. and Worth, W.S.: Inhibition of aldehyde dehydrogenase in brain and liver by cyanamide. Biochem. Pharmacol. 25:2733-2737 (1976).

26. Verbiscar, A.J., Deitrich, R.A., Pratt, E.L. and Tabakoff, B.: Specifications and criteria for biochemical compounds. Supplement, Biogenic Amines and Related Compounds. Natl. Res. Council, National Academy of Sciences, Washington, D.C. (1977).

27. Petersen, D.R., Collins, A.C. and Deitrich, R.A.: Role of cytosolic aldehyde dehydrogenase in control of blood acetaldehyde concentrations. J. Pharmacol. Exptl. Therap. 201:471-481 (1977).

28. Deitrich, R.A., Bludeau, P. and Roper, M.: Induction of different rat liver supernatant aldehyde dehydrogenases by phenobarbital and tetrachlorodibenzo p-dioxin. J. Biol. Chem. 252:6169-6176 (1977).

29. Deitrich, R.A., Bludeau, P., Roper, M. and Schmuck, J.: Induction of aldehyde dehydrogenases. Biochem. Pharmacol. 27:2343-2347 (1978).

30. Lindahl, R., Roper, M. and Deitrich, R.A.: Rat liver aldehyde dehydrogenases immunochemical identity of TCDD-inducible normal liver and AAF-inducible hepatoma isozymes. Biochem. Pharmacol. 27:2463-2465 (1978).

31. Towell, J.F., Erwin, V.G. and Deitrich, R.A.: Nicotinamide adenine dinucleotide phosphate-decanaldehyde adduct as an inhibitor of beef brain NADP-linked aldehyde reductase. J. Med. Chem. 22:1011-1014 (1979).

32. Chipkin, R.E., Melchior, C.L. and Deitrich, R.A.: Interaction of carboxysalsolinol with the ethanol discriminative stimulus. Comm. Psychopharm. 3:159-164 (1979).

33. Melchior, C.L., Mueller, A. and Deitrich, R.A.: Half-lives of salsolinol and tetrahydropapaveroline hydrobromide following intracerebroventricular injection. Biochem. Pharmacol. 29:657-658 (1980).

34. Baker, R., Melchior, C. and Deitrich, R.: The effect of halothane on mice selectively bred for differential sensitivity to alcohol. Pharmacol. Biochem. Behav. 12:691-695 (1980).

35. Duncan, C. and Deitrich, R.A.: A critical evaluation of tetrahydroisoquinoline induced ethanol preference in rats.

Pharmacol. Biochem. Behav. 13:265-281 (1980). 36. Hoffer, B., Taylor, D., Baker, R., Deitrich, R., Seiger, W. and

Olson, L.: Ethanol withdrawal seizures in hippocampus transplanted to the anterior chamber of the eye. Life Sci. 26:239-244 (1980).

37. Lee, K., Dunwiddie, T., Deitrich, R., Lynch, G. and Hoffer, G.: Chronic ethanol consumption and hippocampal neuron dendritic spines: A morphometric and physiological analysis. Exp. Neurol. 71:541-549 (1981).

38. Baker, R.C., Sorensen, S.M. and Deitrich, R.A.: The in vitro metabolism of tertiary butanol by adult rats. Alcoholism: Clin. and Exp. Res. 6:247-251 (1982).

39. Martz, A., Deitrich, R.A. and Harris, R.A.: Behavioral evidence for involvement of gamma aminobutyric acid in the actions of ethanol. Europ. J. Pharmacol. 89:153-162 (1983).

40. Eriksson, C.J.P., Atkinson, N., Petersen, D.R. and Deitrich, R.A.: Blood and liver acetaldehyde concentrations during ethanol oxidation in C57 and DBA mice. Biochem. Pharmacol. 33:2213-2216 (1984).

41. Simpson, V.J., Baker, R. and Deitrich, R.A.: Inducible aldehyde dehydrogenase from rat liver cytosol. Toxicol. Applied Pharmacol. 79:193-203 (1985).

42. Tottmar, O., Nilsson, G., Spuhler, K.P., Petersen, D., Little, R. and Deitrich, R.A.: Application of a high performance liquid chromatography method for screening of aldehyde dehydrogenase deficiency in hair roots from different ethnic groups. Alc.: Clin. Exp. Res. 9:339-343 (1985).

43. Goldman, D., Nelson, R., Deitrich, R., Baker, R., Spuhler, K., Markley, H., Ebert, M. and Merril, C.: Genetic brain polypeptide variants in inbred mice and in mouse strains with high and low sensitivity to alcohol. Brain Res. 341:130-138 (1985).

44. Maring, J. -A., Deitrich, R.A. and Little, R.: Partial purification and properties of human brain aldehyde dehydrogenase. J. Neurochem. 45:1903-1910 (1985).

45. Freedman, R., Waldo, M.C., Alder, L.E., Baker, N., Levin, D. and Deitrich, R.A.: Electrophysiological effects of low dose alcohol on human subjects at high altitude. Alcohol and Drug Research 6:289-297 (1985-1986).

46. Holmes, R.S., Petersen, D.R. and Deitrich, R.A.: Biochemical genetic variants in mice selectively bred for sensitivity or resistance to ethanol-induced sedation. Animal Genetics 17:235-244 (1986).

47. Palmer, M.R., Tottmar, O. and Deitrich, R.A.: Electrophysiological effects of monoamine-derived aldehydes on single neurons in neocortex and cerebellum in rats.

Alcoholism: Clinical and Experimental Research 10:682-685 (1986).

48. Tank, A.W., Deitrich, R.A. and Weiner, H.: Affects of induction of rat liver cytosolate aldehyde dehydrogenase on the oxidation of biogenic aldehydes. Biochem. Pharmacol. 35:4563-4569 (1986).

49. Ullman, M.D., Baker, R.C. and Deitrich, R.A.: Gangliosides of LS and SS mouse cerebellum and hippocampus and cerebellar and whole brain synaptosomal plasma membranes. Alcoholism: Clinical and Experimental Research 11:158-162 (1987).

50. Rabin, R.A., Baker, R.C. and Deitrich, R.A.: Effects of chronic ethanol exposure on adenylate cyclase activities in the rat. Pharmacology, Biochemistry and Behavior 26(4):693-697 (1987).

51. Baker, R.C., Smolen, A., Smolen, T. and Deitrich, R.A.: Relationship Between Acute Ethanol Related Responses in Long Sleep and Short Sleep Mice. Alcoholism: Clinical and Experimental Research 11:574-578, (1987).

52. Deitrich, R.A., Bludeau, P. and Baker, R.C.: Brain ascorbic acid levels: Mice and rats selected for differences in acute reactions to ethanol. Alcohol and Alcoholism 23:57-62 (1988).

53. Deitrich, R.A., Bludeau, P. and Baker, R.C.: Investigations of the role of protein kinase C in the acute sedative effects of ethanol. Alcoholism: Clinical and Experimental Research 13:737-745, (1989).

54. Sakellardis, N., Mangoura, D., Masserano, J.M., Detsis, V., Leoni, C.J., Deitrich, R. and Vernadakis, A.: Developmental profile of glutamine synthetase in lines of mice bred for ethanol sensitivity. J. Neurosci. Res. 24:391-397, (1989).

55. Keir, W.J. and Deitrich, R.A.: Development of central nervous system sensitivity to ethanol and pentobarbital in short- and long-sleep mice. J. Pharmacol. Exptl. Therap. 254:831-835 (1990).

56. Keir, W.J., Kozak, C.A., Chakraborti, A., Deitrich, R.A. and Sikela, J.M.: The DNA sequence of chromosomal location of the murine GABAA ˜1 subunit receptor gene. G enomics 9:390-395 (1991).

57. de Fiebre, C.M., Romm, E., Collins, J.T., Draski, L.J., Deitrich, R.A. and Collins, A.C.: Responses to cholinergic agonists of rats selectively bred for differential sensitivity to ethanol. Alcoholism: Clinical and Experimental Research 15:270-276 (1991).

58. Draski, L.J., Spuhler, K.P., Erwin, V.G., Baker, R.C. and Deitrich, R.A.: Selective breeding of rats differing in sensitivity to the ataxic effects of acute ethanol administration. Alc.: Clin. Exp. Res. 16:48-54 (1992).

59. Gill, K., Menez, J.-F., Lucas, D. and Deitrich, R.A.: Enzymatic production of acetaldehyde from ethanol in rat brain tissue. Alc.: Clin. Exp. Res. 16:910-915 (1992).

60. Lucas, D., Menez, J.-F., Berthou, F., Cauvin, J.-M. and Deitrich, R.A.: Differences in hepatic microsomal cytochrome P-450 isoenzyme induction by pyrazole, chronic ethanol, 3-methylcholanthrene, and phenobarbital in high alcohol sensitivity (HAS) and low alcohol sensitivity (LAS) rats. Alc.: Clin. Exp. Res. 16:916-921 (1992).

61. Ullman, M.D., Ventura, R.F., Deitrich, R.A. and Baker, R.C.: Surface exposure of synaptosomal gangliosides from long-sleep and short-sleep mice. Alc.: Clin. Exp. Res. 16:857-862 (1992).

62. Ullman, M.D., Ventura, R.F., Draski, L.J., Deitrich, R.A. and Baker, R.C.: Ceramide composition of whole brain synaptosomal gangliosides from mice genetically bred for divergent ethanol sensitivities. Alcohol 9:323-326 (1992).

63. Menez, J.-F. Machu, T.K., Song, B.-J., Browning, M.D., and Deitrich R.A., Phosphorylation of cytochrome P4502E1 (CYP2E1) by calmodulin dependent protein kinase, protein kinase C and cAMP dependent protein kinase. Alcohol and Alcoholism, 28, 445-452 (1993).

64. Deitrich, R.A., Draski, L.J., and Baker, R.C. Effect of pentobarbital and gaseous anesthetics on rats selectively bred for sensitivity to ethanol. Pharmacol. Biochem. Behav. 47: 721-725, (1994).

65. Liu, Y., Fay, T., and Deitrich, R.A., Behavioral effects and pharmacokinetics of propofol in rats selected for differential ethanol sensitivities. Alcoholism: Clinical and Experimental Research 19: 874-878, (1995).

66. Avdulov. N.A., Chochina, S.V., Draski, L., Deitrich, R., Wood, W.G., Chronic ethanol consumption alters effects of ethanol in vitro on membrane structure of High Alcohol Sensitive and Low Alcohol Sensitive rats. Alcoholism: Clin. Exp. Res. 19: 886-891, (1995).

67. Zimatkin, S., and Deitrich, R.A., Aldehyde dehydrogenase activities in the brains of rats and mice genetically selected for different sensitivity to alcohol. Alcoholism: Clinical and Experimental Research 19: 1300-1306, (1995).

68. Deitrich, R.A., Bludeau, P., Elk, M.E., Baker, R., Menez, J-F, and Gill, K., Effect of administered ethanol on protein kinase C in human platelets. Alcoholism: Clinical and Experimental Research. 20: 1503-1506, (1996).

69. Dildy-Mayfield, J.E., Mihic, S.J., Liu, Y., Deitrich, R.A., and Harris, R.A., Actions of long chain alcohols in GABAA and glutamate receptors: relation to in vivo effects. British Journal of Pharmacology 118, 378-384, (1996).

70. Erwin, V.G., and Deitrich, R.A., Selective breeding of mice for acute tolerance to ethanol. J. Pharmacol. Exptl. Therap. 279: 1310-1317, (1996).

71. Erwin, V.G., Draski, L.J., and Deitrich, R. A., Neurotensin levels and neurotensin receptor density in HAS and LAS rats. Pharmacology, Biochemistry and Behavior 54: 525-532, (1996).

72. Files, F.J., Samson, H.H., Brice, G.T., Deitrich, R.A., and Draski, L.J., Initiation of ethanol self-administration by the sucrose-substitution method with HAS and LAS rats. Alcoholism: Clinical and Experimental Research 20: 677-681, (1996).

73. Gill, K., Y. Liu and Deitrich, R.A., Voluntary alcohol consumption in BXD recombinant inbred mice: Relationship to alcohol metabolism. Alcoholism: Clinical and Experimental Research, 20: 185-190, (1996).

74. Draski, L., Menez, J.-F., and Deitrich, R.A., Effect of phenobarbital on activity in HAS and LAS rats. Pharmacol. Biochem. Behav. 57:651-657, (1997).

75. Gill, K., and Elk, M.E., and Deitrich, R.A., A description of alcohol/drug use and family history of alcoholism among urban America Indians. American Indian and Alaska Native Mental Health Research 8: 41-52, (1997).

76. Ullman, M.D., Ventura, R.F., Draski, L.J., Deitrich, R.A. and Baker, R.C., Effect of endogenous GM1 on ethanol sensitivity in selectively bred mouse lines. Alcoholism: Clinical and Experimental Research 21:661-665, (1997).

77. Zimatkin, S. and Deitrich, R.A., Ethanol metabolism in brain. Addiction Biology 2:387-399, (1997).

78. Gill, K. and Deitrich, R.A., Acute tolerance to the ataxic effects of ethanol in the short-sleep (SS) and long-sleep (LS) mice. Psychopharmacology 136:91-98, (1998).

79. Liu, Y., and Deitrich, R.A., Role of GABA in the actions of ethanol in rats selectively bred for ethanol sensitivity. Pharmacology, Biochemistry and Behavior 60: 793-801 (1998).

80. Zimatkin, S.M. Liopo, A.V., and Deitrich. R.A., Ethanol metabolism in regions of rat brain Alcoholism: Clinical and Experimental Research 22: 1623-1627 (1998).

81. Gill, K., Elk, M.E., Liu, Y., and Deitrich, R.A., An Examination of ALDH2 Genotypes, Alcohol Metabolism and the Flushing Response in Native Americans. J. Studies of Alcohol 60:149-158, 1999.

82. Erwin, V.G., Gehle, V.M. and Deitrich, R.A., Selectively bred lines of mice show response and drug specificity for genetic regulation of acute functional tolerance to ethanol and pentobarbital. J Pharmacol Exp Ther.; Apr;293(1):188-95 (2000).

83. Deitrich, R.A., Bludeau, P, Erwin, V.G., Phenotypic and genotypic relationships between ethanol tolerance and sensitivity in mice selectively bred for initial sensitivity to ethanol (SS and LS) or development of acute tolerance (HAFT and LAFT). Alcohol Clin Exp Res. May;24(5):595-604 (2000)

84. Zimatkina, T.I., Chernikevich, I.P., Zimatkin, S.M. and Deitrich, R.A., Thiamine status in liver and brain of rats genetically selected for different sensitivity to hypnotic effect of alcohol. Alcohol Clin Exp. Res. Nov; 24(11) 1620-4 (2000).

85. Zimatkin, S.M., Liopo, A.V., Slychenkov, V.S., Deitrich, R.A., Relationship of brain ethanol metabolism to the hypnotic effect of ethanol. I: Studies in outbred animals. Alcohol Clin Exp Res. July, 25(7): 976-81 (2001)

86. Zimatkin, S.M., Liopo, A.V., Satanovskaya, V.I., Bardini, L.R. and Deitrich, R.A., Relationship of brain ethanol metabolislm to the hypnotic effect of ethanol. II: Studies in selectively bred rats and mice. Alcohol Clin Exp Res. July;25(7) 982-8 (2001)

87. Erwin, V.G., Radcliffe, R, and Deitrich, R.A., Neurotensin levels in specific brain regions and hypnotic sensitivity to ethanol and pentobarbital as a function of time after haloperidol administration in selectively bred rat lines. J Pharmacol Exp Ther. No., 299(2):698-704 (2001).

88. Draski, L.J., Bice, P.J., and Deitrich, R.A., Developmental alterations of ethanol sensitivity in selectively bred high and low alcohol sensitive rats. Pharmacol Biochem Behav. Oct-Nov;70(2-3)387-96 (2001).

89. Deitrich, R.A., and Bludeau, P., Interaction between S-propranolol and ethanol in mice selectively bred for ethanol sensitivity, the inbred short-and long-sleep mice. Alc. Clin. Exp. Res. 27:1229-1235, 2003 90. Deitrich, R.A., and Bludeau, P., Short term selection for the interaction between s-propranolol and ethanol in mice. . Alc. Clin.Exp. Res.27:1236-1240, 2003

91. Radcliffe, R., Hoffmann, S.E., Deng. X-S., Asperi, W., Fay, TD., Bludeau, P., Erwin, V.G. and Deitrich, R.A. Characterization of alcohol-tolerant (AT) and alcohol-nontolerant (ANT) rats and in an f2 generation. Behavior Genetics 34: 453-463, 2004

92 Richard A. Radcliffe, R., Erwin, V.G., Draski, L., Hoffmann, S., Edwards, J., Deng, X-S., Bludeau, P., Fay ,T., Lundquist, K., Asperi, W., and . Deitrich, R. QTL Mapping for Ethanol Sensitivity and Neurotensin Receptor Density in an F2 Intercross Derived from Inbred High and Low Alcohol Sensitivity Selectively Bred Rat Lines. (2004) In Press Alcoholism: Clinical

and Experimental Research.

Abstracts, Meeting Reports, etc. Partial list

1. Deitrich, R.A. and Smith, D.L.: Effect of thyroid hormone on butyrate oxidation in vitro. Fed. Proc. 18:382 (1959).

2. Deitrich, R.A., Wein, J. and Hellerman, L.: DPN-linked liver aldehyde dehydrogenase. I. Specificity and Hammett's Sigma Rho function. Am. Chem. Soc. Abstracts, Sept. (1961).

3. Deitrich, R.A.: DPN-linked aldehyde dehydrogenases. II. Inhibitors. Fed. Proc. 21:244 (1962).

4. Erwin, V.G. and Deitrich, R.A.: A non-specific aldehyde dehydrogenase of brain: Distribution, purification and properties. Abstracts of Am. Chem. Soc. 150th Meeting, p. 50C (1965).

5. Kraemer, R.J. and Deitrich, R.A.: The isolation of human liver aldehyde dehydrogenase. The Pharmacologist 9:240 (1967).

6. Deitrich, R.A. and Worth, W.S.: Metabolism of cyanamide in relation to its use in alcoholism and other diseases. Fed. Proc. 27:237 (1969).

7. Deitrich, R.A.: Stimulation of rat liver aldehyde dehydrogenase activity by phenobarbital in vivo. The Pharmacologist 12:298 (1970).

8. Collins, A.C. and Deitrich, R.A.: Effects of in vitro and chronic ethanol treatment on amine and aldehyde metabolism. Fed. Proc. 30:567 (1971).

9. Deitrich, R.A. and Siew, C.: Genetic basis of the increase in rat liver supernatant aldehyde dehydrogenase by phenobarbital. Fed. Proc. 30:1208 (1971).

10. Deitrich, R.A. and Lieber, C.S.: Coordination of research training in professional training on alcoholism. Ann. NY Acad. Sci. 178:70-74 (1971).

11. Robbins, H.M. and Deitrich, R.A.: Studies on the alcohol dehydrogenase: 4-(chloroacetamido)-pyrazole, CAP, a potential active-site directed irreversible alkylating agent. Abstracts 164th Am. Chem. Soc. Meeting Med. Chem. 44: (1972).

12. Deitrich, R.A.: Characteristics of genetically-determined, phenobarbital-induced aldehyde dehydrogenase activity in rat liver. Abstract 5th Int. Congress Pharm., p. 54 (1972).

13. Siew, C., Deitrich, R.A. and Erwin, V.G.: The localization, purification and properties of rat liver mitochondrial aldehyde

dehydrogenase. Fed. Proc. 33:539 (1974). 14. Roper, M., Strock, T. and Deitrich, R.A.: Phenobarbital and

tetrachlorodibenzo-p-dioxin induce different isoenzymes of aldehyde dehydrogenase. Fed. Proc. (1975).

15. Deitrich, R.A.: Book Review - Biochemical Pharmacology of Alcoholism. Majchrowicz, Ed. (ed.), Alcohol Health and Research World I. pp. 24-25 (1976).

16. Duncan, C. and Deitrich, R.A.: Role of tetrahydroisoquinoline alkaloids in ethanol preference. Fed. Proc. 37:420 (1978).

17. Melchior, C.L., Mueller, A. and Deitrich, R.A.: Half-life of tetrahydropapaveroline and salsolinol following injection into the cerebral ventricle of rats. Fed. Proc. 37:420 (1978).

18. Tabakoff, B., Ritzman, R.F., Ruju, T.S. and Deitrich, R.A.: Characterization of acute and chronic tolerance in mice selected by inherent differences in sensitivity to ethanol. 10th Annual Medical-Scientific Conference NCA/AMSA/RSA (1979).

19. Baker, R.C., Sorenson, S.M., Eby, S.R. and Deitrich, R.A.: Acetone excretion following t-butanol treatment in rats. 3rd Int. Symp. Alcohol and Aldehyde Metabolizing Systems (1979).

20. Petersen, D.R., Eriksson, C.J.P. and Deitrich, R.A.: Effect of pyrazole and 4-methylpyrazole on in vivo acetaldehyde metabolism in the rat. Drug & Alcohol Dependence 6:24-25 (1980).

21. Eriksson, C.J.P., Deitrich, R.A., Clay, K. and Petersen, D.R.: Factors affecting the duration of ethanol-induced loss of righting reflex. XI Annual Nordic Meeting on Biological Alcohol Research, Helsinki, (1980)

22. Baker, R., Wimer, R. and Deitrich, R.A.: Cerebellar phospholipid content in SS and LS mice. Alcoholism, Clin. Exp. Res. 6:135 (1982).

23. Deitrich, R.A., Baker, R., Markley, H., Nelson, R., Ebert, M. and Merril, C.: Polypeptide differences in brains of mice with different ethanol sensitivity. Alcoholism, Clin. Exp. Res. 6:293 (1982).

24. Baker, R.C., Spuhler, K.P., Palmer, M.R. and Deitrich, R.A.: Inbred strain differences on traits related to behavioral and physiological responses to acute ethanol. Alcoholism, Clin. Exp. Res. 7:105 (1983).

25. Sakellaridis, N., Deitrich, R. and Vernadakis, A.: Evaluation of adenylate cyclase in chicks in ovo. Am. Soc. Neurochem. Abst. 283 (1983).

26. Sakellaridis, N., Mangoura, D., Deitrich, R. and Vernadakis, A.: Microenvironment and glial growth in culture. J. Neurochem. (Suppl. 37), 37 (1983).

27. Davies, D.L., Sakellaridis, N., Deitrich, R. and Vernadakis, A.: Ethanol-related changes in adenylate cyclase activity in glial cell cultures. The Pharmacologist 25:63 (1983).

28. Goldman, D., Nelson, R., Deitrich, R.A., Baker, R.C., Markley, H., Ebert, M. and Merril, C.R.: Genetic brain polypeptide variants in alcohol-sensitive (LS) and insensitive (SS) mice. Alc.: Clin. Exp. Res. 8(1):93 (1984). Maring, J.A. and Deitrich, R.A.: Isolation and characterization of human brain aldehyde dehydrogenase. Alc.: Clin. Exp. Res. 8(1):105 (1984).

29. Rabin, R.A., Baker, R.C. and Deitrich, R.A.: Interactions between diet, chronic ethanol exposure and the response to acute ethanol insult. Alc.: Clin. Exp. Res. 8:114 (1984).

30. Spuhler, K., Fossom, L., Palmer, M. and Deitrich, R.A.: Differences in acute sensitivity to effects of ethanol in rat inbred strains. Alc.: Clin. Exp. Res. 8:121 (1984).

31. Ullman, M.D., Baker, R. and Deitrich, R.A.: Cerebellar gangliosides from LS and SS mouse strains. Alc.: Clin. Exp. Res. 8:124 (1984).

32. Schwappach, J.R., Spuhler, K.P. and Deitrich, R.A.: Aldehyde dehydrogenase polymorphism in American Indians. American Federation for Clinical Research, 34:18A (1986).

33. Deitrich, R.A. and Baker, R.: Interaction of phorbol ester with ethanol in the central nervous system. The Pharmacologist, (1988).

34. Deitrich, R.A.: Genetic aspects of alcoholism - an overview. Int. Symp. on Alcohol and the Brain. Australian Drug and Alcohol Review 7:5-7 (1988).

35. Deitrich, R.A.: Genetic aspects of alcoholism - an overview. Int. Symp. on Alcohol and the Brain. Australian Drug and Alcohol Review 7:5-7 (1988).

36. Deitrich, R.A.: Selective breeding in alcohol research. Int. Symp. on Alcohol and the Brain. Australian Drug and Alcohol Review 7:13-15 (1988).

37. French, T.A., Masserano, J.M., Spuhler, K., Deitrich, R.A. and Weiner, N.: Preliminary characterization of catecholamine systems in rats selectively bred for differential acute sensitivity to ethanol. Alc.: Clin. Exp. Res. 307 (1988).

38. Ullman, M.D., Ventura, R.A., Deitrich, R.A. and Baker, R.C.: Synaptosomal gangliosides: Surface exposure in ethanol. Alc.: Clin. Exp. Res. 313 (1988).

39. Keir, W.J. and Deitrich, R.A.: Developmental effects of pentobarbital on the sleep time response in SS and LS mice. Alc.: Clin. Exp. Res. 344 (1988).

40. Keir, W.J., Deitrich, R.A. and Sikela, J.M.: Cloning of the mouse GABA-benzodiazepine receptor ˜1 subunit in a study

of alcohol neurosensitivity. FASEB J. 3:A429 (1989). 41. Deitrich, R.A., Bludeau, P. and Baker, R.C.: Protein kinase C

in rat brain: Effect of ethanol. Alc. Clin. Exp. Res. 307 (1989).

42. Menez, J.-F. and Deitrich, R.A.: Induction of cytosolic ALDH and change in protein kinase C activity in liver. Alc.: Clin. Exp. Res. 333 (1989).

43. Menez, J.-F., Browning, M.D., Petersen, D. and Deitrich, R.A.: Inhibition of protein kinase C by aldehydes. Alc.: Clin. Exp. Res. 333 (1989).

44. Baker, R.C., Bludeau, P.A., Tucker, M.S. and Deitrich, R.A.: Activation of brain protein kinase C by phosphatidylethanol. Alc.: Clin. Exp. Res. 14:269 (1990).

45. Doherty, J., Baker, R.C. and Deitrich, R.: Studies with pyrethroids (kadethrin and deltamethrin) and lindane in ethanol sensitive (LS) and insensitive (SS) mouse strains. FASEB J. 4:(I)A744 (1990).

46. Keir, W.J., Kozak, C., Sikela, J.M. and Deitrich, R.A.: The cDNA sequence and chromosomal location of the murine GABAA ˜-1 recep tor gene. Alc.: Clin. Ex. Res. 14:302 (1990).

47. Lucas, D., Menez, J.-F., Berthou, F. and Deitrich, R.A.: Acetaldehyde bound to microsomes and microsomal function in HAS and LAS rats. Alc.: Clin. Exp. Res. 14:313 (1990).

48. Lucas, D., Menez, J.-F., Berthou, F. and Deitrich, R.A.: Differences in microsomal functions between HAS or LAS rats after chronic treatment with ethanol and/or 3-methylcholanthrene. ESBRA (1990).

49. Menez, J.-F. and Deitrich, R.A.: Decrease in protein kinase C activity after chronic administration of pyrazole. Alc.: Clin. Exp. Res. 14:318 (1990).

50. Menez, J.-F. and Deitrich, R.A.: Changes in liver protein kinase activities after acute and chronic administration of ethanol. Alc.: Clin. Exp. Res. 14:318 (1990).

51. Menez, J.-F. and Deitrich, R.A.: Increase in phorbol ester binding in liver microsomes after chronic administration of ethanol. FASEB J. 5:A4865 (1991).

52. Menez, J.F., Draski, L. and Deitrich, R.A.: Differences in phenobarbital sensitivity in HAS and LAS rats before and after chronic administration of ethanol. Alc.: Clin. Exp. Res. 14:318 (1990).

53. Menez, J.-F., Lucas, D., Berthou, F. and Deitrich, R.A.: Inhibition by phorbol myristate acetate (PMA) of cytochrome P-450 induction by acetone. FASEB J. 4:(II)A887 (1990).

54. Draski, L.J. and Deitrich, R.A.: Developmental alterations in ethanol sensitivity of HAS and LAS rats. Alc.: Clin. Exp. Res.

15:321 (1991). 55. Ullman, M.D., Ventura, R.F., Deitrich, R.A. and Baker, R.C.:

Ceromides of synaptosomal gangliosides from LS and SS mice. Alc.: Clin. Exp. Res. 15:326 (1991).

56. Gill, K., Menez, J.F., Lucas, D. and Deitrich, R.A.: Acetaldehyde production in rat brain tissue. Alc.: Clin. Exp. Res. 15:351 (1991).

57. Menez, J.-F., Machu, T.K., Song, B.J., Browning, M.D. and Deitrich, R.A.: Phosphorylation of cytochrome P-450IIE1 by cAMP dependent protein kinase, calmodulin dependent protein kinase and protein kinase C. Alc.: Clin. Exp. Res. 15:352 (1991).

58. Menez, J.-F. and Deitrich, R.A.: Inhibition of phorbol ester binding in liver microsomes by barbiturates in vitro. Alc.: Clin. Exp. Res. 15:354 (1991).

59. Menez, J.-F. and Deitrich, R.A.: Change in phorbol ester binding but not in protein kinase C activity in liver during induction using phenobarbital, a tumor promoter. PAMM Winter Meeting, Pharmacology and Molecular Mechanism Group, January 14-16, (1993), Brest, France.

60. Liu, Y., Fay, T., and Deitrich, R.A., Behavioral effects and pharmacokinetics of propofol in rats selected for differential ethanol sensitivities. Alc. Clin. Exp. Res. 18, 485 (1994).

61. Deitrich, R. A., Bludeau, P., Draski, L.J., Ullman, M.D., and Baker, R.C., The effect of gangliosides on protein phosphorylation in LS and SS mouse brain in vitro. Alc. Exp. Clin. Res. 18, 49A (1994).

62. Draski, L.J., and Deitrich R.A., Developmental changes in ethanol-induced locomotor inhibition in HAS and LAS rats. Alc. Clin. Exp. Res. 18, 49A (1994).

63. Shoshina, S.V., Avdulov. N.A., Draski, L., Deitrich, R., Wood, W.G., Chronic ethanol consumption alters in vitro effects of ethanol on membrane structure of HAS and LAS rats. Alc. Clin. Exp. Res. 18, 484 (1994).

64. Bice, P.J., Effects of ethanol on the activity levels of the HAS, LAS and CAS rats. Alc. Clin. Exp. Res. 18, 485 (1994).

65. Draski, L.J., Fay, T.,, Erwin, V.G., and Deitrich, R.A., Genotype-dependent tolerance to ethanol following chronic exposure in HAS and LAS rats. Alc. Clin. Exp. Res. 18, 521 (1994).

66. Gill, K., Deitrich, R.A., and Erwin, V.G., Alcohol related behaviors in the BXD recombinant inbred (RI) strains of mice. Alc. Clin. Exp. res., 19, 12A, (1995).

67. Draski, L.J., Liu, Y., and Deitrich, R.,A., Differential effects on behavior by ketamine and MK-801 in ethanol sensitive HAS and LAS rats. Alc. Clin. Exp. Res. 19, 46A, (1995).

68. Liu, Y., Fay, T., and Deitrich R.A., Differential response to etomidate in high and low ethanol sensitive rats. Alc. Clin. Exp. Res. 19, 46A, (1995).

69. Lucas, D., Gill, K., Menez, J.-F. and Deitrich R.A., Differences in cytochrome P450 2E1 and 1A1 genotyping between American Indians and Caucasians. Alc. Clin Exp. Res., 19, 74A, (1995).

70. Draski, L.J., Fay, T., and Deitrich, R.A., Differential dose-response curves to MK801 and interaction with ethanol in HAS and LAS rats. Alc. Clin. Exp. Res., 122, 24A, (1996).

71. Liu, Y., Fay, T., and Deitrich, R.A., Effects of etomidate and propofol on GABA receptor-chloride channel complex in rats selectively bred for differential sensitivity to alcohol. Alc.: Clin. Exp. Res., 124, 24A, (1996).

72. Liu, Y., Fay, T., and Deitrich, R.A., Differential response to ketamine in high and low ethanol sensitivity rats. Alc. Clin. Exp. Res., 125, 24A, (1996).

73. Liu, Y., Fay, T., and Deitrich, R.A., Effects of dehydroisoandrosterone on behavior and GABAa receptor-chloride channel complex in rats selectively bred for differential sensitivity to alcohol. Alc. Clin. Exp. Res., 69, 15A, (199).

74. Erwin, V.G., Gehle, V., and Deitrich, R.A., Further characterization of mice selectively bred for acquisition of high (HAFT) and low (LAFT) acute functional tolerance to ethanol. Alc. Clin Exp. Res., 80, 17A, (1997).

75. Deitrich, R.A., Bludeau, P. and Erwin, V.G., Phenotypic and genetic studies of acute functional tolerance, very rapid acute functional tolerance and initial sensitivity to ethanol in mice. Submitted, ISBRA Mtg., June 27-July 2, (1998).

76. Parker, E., Draski, L., Bludeau, P., Fay, T. and Deitrich, R.A., Allele frequencies in rat lines selected for ethanol sensitivity. Alc.: Clin. Exp. Res.,22: 100A (1998).

77. Zimatkin, S.M., Liopo, A.V., Zackharov, O.Y. and Deitrich, R.A., Ethanol metabolism in rat brain. Exp. Toxic. Pathol. 50:145, (1998). .