curriculum vitae - university of colorado · web viewsamiha m. mateen, molecular toxicology...

Rajesh Agarwal, Ph.D.

CURRICULUM VITAERajesh Agarwal, Ph.D.

Office address: Department of Pharmaceutical SciencesSchool of PharmacyUniversity of Colorado Health Sciences Center4200 East Ninth Street, Box C238Denver, CO 80262

Office telephone number: (303) 315-1381

Office Fax number: (303) 315-6281

E-mail: [email protected]

Education1975 B.Sc.: Chemistry, Botany, and Zoology - Lucknow University, India. 1976 B.Sc. (Hons.): Organic Chemistry - Lucknow University, India.1977 M.Sc.: Organic Chemistry - Lucknow University, India.1981 Ph.D.: Bioorganic Chemistry (Medicinal) - Lucknow University, India.

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Academic Appointments3/2001- Professor (7/04: Tenure), Department of Pharmaceutical Sciences,

School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado.

7/2001- Graduate Faculty, Toxicology/Pharmaceutical Sciences, Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado.

1998- Full Member, University of Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, Colorado.

2000-2001 Senior Scientist (Professor), Center for Cancer Causation and Prevention, AMC Cancer Research Center, Denver, Colorado.

1998-2000 Scientist (Associate Professor), Center for Cancer Causation and Prevention, AMC Cancer Research Center, Denver, Colorado.

1992-1997 Assistant Professor, Department of Dermatology, Case Western Reserve University, Cleveland, Ohio.

1995-1997 Assistant Professor, Division of General Medical Sciences (Oncology) and CWRU Cancer Center, Case Western Reserve University, Cleveland, Ohio.

1991-1992 Senior Research Associate, Department of Dermatology, Case Western Reserve University, Cleveland, Ohio.

1989-1991 Research Associate, Department of Dermatology, Case Western Reserve University, Cleveland, Ohio.

1988-1989 Research Associate, Department of Pathology/Department of Biology, Case Western Reserve University, Cleveland, Ohio.

1985-1988 Assistant Professor, Chemistry Department, Manipur University, Imphal, India.

1983-1985 Research Associate/Scientist Pool, Industrial Toxicology Research Center, Lucknow, India.

1978-1982 Junior/Senior/Post-Doctoral Research Fellow, Chemistry Department, Lucknow University, Lucknow, India.

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Professional Experience Prevention of cancer: Dietary and synthetic agents - cellular, biochemical and

molecular mechanisms employing biochemical and molecular biological techniques. Evaluation of cancer chemopreventive potential of dietary constituents employing several long-term animal tumor bioassay protocols, and short-term animal and cell culture assays. Models include skin, prostate, breast, lung, colon, bladder.

Mechanism of cancer prevention: Oncogenes and suppressor genes - ras oncoprotein p21 processing enzyme farnesyltransferase, cell cycle modulation, p53, cyclins, cyclin dependent kinases, cyclin dependent kinase inhibitors (Cip 1/p21, Kip1/p27), apoptosis, and mitogenic and anti-apoptotic signaling pathways.

Therapy of cancer: Dietary and synthetic agents - cell culture studies and nude mice xenograft models.

Carcinogenesis - causation and mechanistic studies employing enzyme bioassay and molecular biology approaches, cell culture technique and long-term animal tumor studies.

Drug Metabolism - purification of cytochrome P450 1A1, and characterization by SDS-PAGE, Western blotting, peptide mapping and sequencing.

Photodynamic therapy -in vivo and in vitro mechanisms of photodynamic effect of photosensitizers, specifically phthalocyanines, and evaluation of PDT effect of phthalocyanines in murine skin tumor models.

Protein chemistry - isolation, characterization and structure determination of proteins by chemical modifications, photo cross-linking, HPLC, SDS-PAGE analysis, Western blotting, peptide analysis and N-terminal amino acid sequencing.

Medicinal chemistry - synthesis of different heterocyclic nuclei like indoles, quinazolones, imidazolones, pyrazolones, thiazolidenes etc., their structural characterization and screening for CNS disorders and activity as anti-inflammatory agents. Isolation and characterization of phytochemicals as potential cancer preventive agents.

Consulting Activity Consultant with Indena, Italy, on developing silibinin for prostate cancer

prevention and treatment in the patients, 2003.

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Teaching Activity1. Undergraduate and Graduate Courses

Pharm D Courses at SOP, UCHSC:Fall, 2001-2004 IOS X, PHRD 5710, Pharmacology of Antimicrobial

agents (P3).Fall, 2001 Instructional Methods II, PHRD 4200 (P1).Spring, 2002-2005 IOS I, PHRD 3750, Endocrine System (P1). Fall, 2002-2005 IOS IX, PHRD 5700, Endocrine Systems – Hormone

Regulation Review (P3), Co-instructor with Dr. Altiere.Spring, 2003-2005 PHRD 5860, Alternative Medicine Course.Spring, 2002-Present: IOS VI, PHRD 4750, Cancer Chemotherapy (P2).

Graduate Courses at DOPS, SOP, UCHSC:Fall, 2002-2004 Course Coordinator, Topics in Toxicology Research.Fall, 2002-2005 Instructor, Experimental Methods in Toxicology.Spring, 2003 Instructor, Pharmacology Course/Natural Products

and Chemoprevention.Spring, 2005 Instructor, TXCL-PHSC 7530 Cancer: Experimental

and Medical Aspects, Cancer Chemoprevention.Spring, 2002-2006 Instructor, Principles of Toxicology II: Drug

Metabolism - Sulfate Conjugation & Acylation.Spring, 2006 Course Co-Director, Environmental and Target Organ

Toxicology, TXCL 7323Fall, 2006 Course Director and Instructor, TXCL-PHSC 7400

Ethical Issues in Tox & Pharm Sci.Spring, 2002-Present: Instructor, Principles of Toxicology II: Heart &

Vascular.Fall, 2005-Present Instructor, Principles of Toxicology I, Cancer

Chemoprotection.Fall, 2005-Present: Instructor, Principles of Toxicology I, Signal

Transduction.Winter, 2005-Present Instructor, TXCL-PHSC 7400 Ethical Issues in Tox &

Pharm Sci.

2. Continuing EducationLectures and Seminars to Residents at Department of Dermatology, Case Western Reserve University, Clevelend, OH. 1993-1997. The format included: Journal Club, Lectures related to molecular biology and other laboratory techniques, and Laboratory Methods demonstration.

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Advising ActivityPharm D.Advisor to Todd Allen and Julie Ball, P3 students, for their seminar presentation on Complementary and Alternative Therapies for Cancer Treatment, December 2002.

Advisor to Ylan Cao and Kiesha Van Valkenburgh, P3 students, for their seminar presentation on Epidermal Growth Factor Receptor: A molecular target for epithelial cancer prevention and therapy, April, 2004.

Advisor to Vanessa Rogers and Jennifer Trask, P3 students, for their seminar presentation on Nutritional supplements: good or bad for cancer patients, November, 2006.

Advisor to Ajay Gupta and Galina B Yermilova, P3 students, for their seminar presentation on Nutritional supplements: good or bad for cancer patients, September, 2007.

Ph.D. StudentsSrirupa Roy, Molecular Toxicology Graduate Program, DOPS (2003-).Samiha M. Mateen, Molecular Toxicology Graduate Program, DOPS (2007-).

Graduate Students Rotations – UCHSC, DOPSKathryn Zolman (2001)Jessica Krank (2002)Marta Narvaez (2002)Heather Walczak (2002)Srirupa Roy (2002)Heather Leitner (2003)Samiha M. Mateen (2007)Sangeeta Shrotriya (2007)

Graduate Students Committees – UCHSC, DOPSMember on Charles Hughes (M.S. Defense Committee, graduated 2002)Member on Jeanmarie Zodrow (graduated 2003)Member on Katherine Peebles (graduated 2005)Member on Mark Reimers (2001-2005, graduated 2005)Chair on David Carbone (2001-2005, graduated 2005)Chair on Brante Sampey (2001-2005, graduated 2005)Chair on Ileana Vargas (2001-2005, graduated with Masters, 2005)Member on Heather Walczak (2002-2007, graduated 2007)Member on Elizabeth Redente (2003-)Chair on James R. Roede (2006-)Chair on Jason Fritz (2007-)Member on Yan Chao (2007-)

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Undergraduate StudentsName Title of Research Project Training Period Galvin, Brea Phytochemicals and skin cancer. 2003

Haque, A. Search for potential cancer chemo- 1993-1995preventive agents.

Julka, K. Epidermal growth factor receptor 1996and cancer prevention by silymarin.

Kale, S. Phytochemicals and Prostate Cancer 2000Prevention.

Kapoor, Ruchi Phytochemicals and prostate cancer. 2003

Krishnamurthi, R. Evaluation of antioxidant potential 1994-1995of silymarin.

Liem, V.K. Ha-Ras oncogene and skin cancer. 1993

Sathi, Kunji Phytochemicals and prostate cancer. 2003

Sequeira, Sabina Flavonoids and bladder cancer. 2003

Sharma, Kapil Phytochemicals and Prostate cancer 2001

Sinha, Arjun Prostate cancer therapeutic agents. 2006

Postdoctoral Fellows/ FacultiesName Title of Research Project Training Period Current Position Ahmad, N., Ph.D. Cell cycle control and apoptosis 1996 to 1998 Associate Prof.,

in skin cancer therapy. Univ of Madison

Balaiya, Vel, Ph.D. CRC and Phytochemicals 2007- Post-doc (current)

Bhatia, N., Ph.D. Signal transduction, cell cycle 1998-2000 Post-docregulation and prostate cancer.

Broussard, Alton Laboratory Manager 2005- PRA (current)

Chittezhath, M, Ph.D. Silibinin and epithelial cancer prevention. 2004-2005 Res. Assoc., Emory

Deep, Gagan, Ph.D. Flavolignan and cancer prevention. 2004- Res. Assoc. (current)

Dhanalakshmi, S., Ph.D.Cancer Prevention via targetting cell 2000-2004 Res. Scientist, Biotech, survival signaling. India.

Flaig, Thomas, M.D. Silibinin and prostate cancer 2005- Assistant ProfessorOncology Div, UCDHSC

Gali, H., Ph.D. Epidermal growth factor receptor 1996 Professor, Lebanonand cancer prevention by silymarin.

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Javed, S., Ph.D. Mechanism of skin chemical 1993, 1996 Science Writer, India

carcinogenesis.

Katiyar, S.K., Ph.D. Skin cancer chemoprevention: 1992-1995 Associate Prof, mechanism and long-term tumor studies. Univ of Alabama

Kaul, Nidhi, M.D. GSE and cancer prevention. 2006-2007 Internal Medicine Residency, NY

Kaur, M., Ph.D. Silibinin and lung cancer prevention. 2003- Res. Assoc. (current)

Khan, S.G., Ph.D. Ras oncogene, farnesyltransferase 1992-1995 Tenured Scientist,and skin carcinogenesis. NCI/NIH, Intramural

Kuhn, C., M.D. Metabolism of chemical carcinogens 1992-1993 Private Practice,in mouse and human epidermal cells. Dermatology, USA

Lahiri, M., Ph.D. Photocarcinogenesis and skin cancer 1995-1996 Biotech Sales Rep,

Chemoprevention. India

Mallikarjuna, GU, Ph.D. Skin cancer prevention by silibinin. 2002- Res. Assoc. (current)

Mohan, R.R., Ph.D. Ras p21 processing, retinoids and skin 1993-1995 Associate Prof,tumor progression. Univ. of MO

Mohan, S., Ph.D. Silibinin and skin cancer prevention. 2003-2005 Post-doc, Univ SouthCarolina

Pal, Arttatrana, Ph.D. CEES toxicity and Rescue 2007- Res. Assoc. (current)

Rajamanickam, S., Ph.D. CRC and Phytochemicals 2007- Post-doc (current)

Raina, Komal, Ph.D. Silibinin efficacy in epithelial cancer. 2005- Post-doc (current)

Ramasamy, K., Ph.D. Silibinin and lung cancer 2007- Post-doc (current)

Rana, Sumeet, M.Phil. CEES toxicity and Rescue 2006 PRA (current)

Sharma, Girish, Ph.D. Grape seed extract and breast cancer. 2001-2003 Assistant Prof. Res.,Univ. of SC

Sharma, Y., Ph.D. Mechanism of silymarin’s anti- 1998-2000, Professor,carcinogenic activity in prostate cancer. 2007 Lucknow Univ., India

Singh, Rana P., Ph.D. Skin cancer prevention by silibinin. 2000-2006 Associate Prof., JNUNew Delhi, India

Tewari-Singh, N., Ph.D. CEES toxicity and Rescue 2006- Res. Assoc. (current)

Tyagi, Alpana, Ph.D. Phytic acid and prostate cancer: role 1999- Res. Assoc. (current)

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of receptor endocytosis.

Tyagi, Anil, Ph.D. Phytochemicals and Cancer Prevention: 2000-2004 Res. Assoc., UCHSCIdentification of active compounds.

Varghese, Leyon, Ph.D. Phytoprevention of angiogenesis. 2004-2005 Res. Assoc., SingaporeUniversity

Zhao, J., Ph.D. Phytochemicals and skin cancer 1998-2000 Scientist, Biotech Co.Prevention.

Zi, X., MD, Ph.D. Signal transduction & cell cycle 1996 to 1998 Assistant Prof., regulation in cancer prevention. Univ of California, Irwin

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Administrative Activity and University Service Member, Core Curriculum Committee, Department of Dermatology, CWRU,

1994-1997. Member, Academic Computer Committee, Department of Dermatology, CWRU,

1996-1998. Chair, Budget Sub-committee for Academic Computer Committee, Department

of Dermatology, CWRU, 1996-1998. Member, Safety Committee, AMC Cancer Center, Denver, CO, 1998-1999. Member, Biohazard Committee, AMC Cancer Center, Denver, CO, 1999-2000. Member, ASPA Committee, AMC Cancer Research Center, Denver, CO, 2000-

2001. Chair, Sunscreen Certification Committee of ASPA, AMC Cancer Research

Center, Denver, CO, 2000-2001.

At UCHSC Member, Toxicology Graduate Program Admission Committee, DOPS, SOP,

2001- Member, Space Committee, SOP, 2002-2004. Member, Search Committee, Basic Science/Prostate Cancer Faculty Candidate,

Univ. Colorado Cancer Center, UCHSC, 2002. Chair, Student Admission and Affairs Sub-committee, Toxicology Graduate

Program, DOPS, SOP, 2002- Member, Curriculum Sub-committee, Toxicology Graduate Program, DOPS,

SOP, 2002. Co-Organizer, Seminar Series for Toxicology Graduate Program, DOPS, 2002-

2003. Co-Organizer, Journal Club for Toxicology Graduate Program, DOPS, 2002-

2003. Organizer, Seminar Series for Toxicology Graduate Program, DOPS, 2003-

2004. Organizer, Journal Club for Toxicology Graduate Program, DOPS, 2003-2004. Member, Post-doctoral Task Force, UCHSC, represented SOP, DOPS, 2003. Member, Molecular Toxicology Faculty Search Committee, DOPS, SOP, 2002-

2003. Member, DOPS Research Committee, 2003- Member, DOPS Appointment, Promotion and Tenure Committee, 2004-2006;

2006-2008. Chair, DOPS Appointment, Promotion and Tenure Committee, 2005-2006. Member, Building Committee, Pharmaceutical Research Center of the Skaggs

School of Pharmacy and Pharmaceutical Sciences, 2007- Chair, Search Committee for PK/PD Faculty Position, DOPS, SOP, UCHSC,

2007.

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Professional Activity and Public ServiceMembership in Professional Organizations

Member, American Association for Cancer Research. Member, American Association for the Advancement of Science. Member, American Society for Photobiology. Member, Society for Investigative Dermatology, USA (upto 2000).

Grant Review Panels Research Advisory Group Proposals from Veterans Administration, Washington

DC, 1994-1995. Merit Review Proposals from Veterans Administration, Washington DC, 1994-

1995. Member, Special Emphasis Panel on Cancer Chemoprevention, National Cancer

Institute, NIH, Bethesda, MD, 1997-1998. Member, NIH/NCRR Site Visit Team to the Florida International University Res.

Ctr. in Minority Inst Program, March, 1999. Ad-hoc Member, Metabolic Pathology Study Section, NCI, NIH, March 13-15,

2000. Ad-hoc Member, Metabolic Pathology Study Section, NCI, NIH, June 26-28,

2000. Member, NCI/NIH Site Visit Team for Program Project on “Inhibition of

Carcinogenesis by Tea and Tea Constituents”, Rutgers University, May 17-19, 2000.

Chairman, NCI/NIH Special Emphasis Panel, ZRG1 CONC (02)M, July 19, 2000. Member, NCI/NIH Special Emphasis Panel, ZRG1 ET-2 03, December 12, 2000. Member, NCI/NIH Teleconference Review Panel for Program Project on

“Inhibition of Carcinogenesis by Tea and Tea Constituents”, Rutgers University, January 11, 2001.

Ad-hoc Member, Chemical Pathology Study Section, NCI, NIH, January 17-19, 2001.

Ad-hoc Member, Chemical Pathology Study Section, NCI, NIH, June 11-13, 2001.

Ad-hoc Member, Subcommittee-Cancer Epidemiology, Prevention and Control Study Section, NCI, NIH, April 4-6, 2001.

Member, California Breast Cancer Research Program (Innovative Treatments) Review Committee, CA, April 20-21, 2001.

Member (mail reviewer), Ohio Cancer Research Associates Grant Review, Columbus, OH, May-June, 2001.

Member (mail reviewer), Special Emphasis Panel, Evaluation of Chemopreventive Agents by In Vivo Screening, NCI, NIH, June, 2001.

Member, NIEHS Special Emphasis Panel, ZES1 BKW-C (RO), NIH, July 15-18, 2001.

Member/Reviewer (by Mail), Biomedical Research Council, Singapore, July 2001.

Member, NCI Special Emphasis Panel, ZRG1 CPA-02, October 11, 2001.

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Member, NCI Special Review Committee Meeting, ZRG1 PTHB 01 M, November 7, 2001.

Member, California Breast Cancer Research Program (Innovative Treatments) Review Committee, CA, April 27-29, 2002

Special Reviewer (by mail), U.S. Civilian Research and Development Foundation, June 2002.

Member/Reviewer (by Mail), Biomedical Research Council, Singapore, July 2002.

Member, NCI Special Emphasis Panel, ZCA1 SRRB-Q (J1) Cooperative Grants for Nutritional Modulation of Genetic Pathways Leading to Cancer, November 6-8, 2002.

Member, California Breast Cancer Research Program (Innovative Treatments) Review Committee, CA, March 29-31, 2003.

Ad-hoc Member, Subcommittee-Cancer Epidemiology, Prevention and Control Study Section, NCI, NIH, July 29-30, 2003.

Member, NCI/NIH Teleconference Review Panel for Supplement to Program Project on “Inhibition of Carcinogenesis by Tea and Tea Constituents”, Rutgers University, February 18, 2004.

Member, NCI Special Emphasis Panel ZCA1 SRRB-Y (M1), Developmental/Pilot Projects in Cancer Complementary and Alternative Medicine, March 8-10, 2004.

Member, European Science Foundation Exploratory Workshop Review Pannel, France, 2004.

Reviewer, Pilot Project Program, Center for Research on Environmental Disease, UT MD Anderson Cancer Center, Science Park Division, Texas, 2004.

Reviewer, Biomedical Research Council Research Proposals, Singapore, 2004. Member, NCI Special Review Committee Meetings (teleconference reviews),

3/11/2002, 6/28/2002, 7/18/2002, 11/14/2002, 11/19/2002, 4/1/2003, 7/9/2003, 7/24/2003, 11/17/2003, 4/7/2004, 4/12/2005, 7/26/2005, 11/1/2005, 5/25/2006, 10/30/06.

Regular Member, Cancer Etiology (formerly Chemical Pathology) Study Section, NCI, NIH, October, 2001 to June, 2005.

Member, Review Panel RFA-A1-04-045, Centers for Countermeasaures against Radiation, ZCA1 SRRB-E (01), June 20-22, 2005.

Mail Reviewer, University of Kansas, Center for Cancer Experimental Therapeutics, Center of Biomedical Research Excellence (COBRE), NIH, grant review, September, 2005.

Mail Reviewer, Research Management Group, Philip Morris External Research Program, November, 2005.

Ad-hoc Member, Cancer Etiology Study Section, NCI, NIH, February 13-15, 2006; June 19-20, 2006; October 16-17, 2006; February 12-13, 2007; June 11-12, 2007.

Member, California Breast Cancer Research Program (Innovative Treatments) Review Committee, CA, March, 2006, 2007.

Member of the Review Committee Site Visit Team, NCI, IRG Subcommittee A (Cancer Centers P30 Program), Moffitt Cancer Center, University of South Florida, Tempa, FL. June12-14, 2006.

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Member, Peer Review Panel, DOD-Prostate Cancer Research Program, Exploration: Hypothesis Development #3, May-june, 2006.

Member, Teleconference Peer Review Panel, University of Connecticut, Center for Health, Intervention and Prevention Seed Grants Program, August 4 th, 2006.

Member, American Institute for Cancer Research (Panel 1, Prevention Research) Review Committee, Washington DC, March, 2007; August, 2007.

Member, NCCAM SEP ZAT1 SM-07 Review Committee for Centers of Excellence for Research on Complementary and Alternative Medicine (CERC), Bethesda, MD, June 20th to 22nd, 2007.

Member On-site Visit Team, Austria Government Cancer Center Program, Vienna, Austria, September 20th, 2007.

Mail Reviewer, French National Cancer Institute Grant Review Panel, September 17, 2007.

Ad-hoc Member, Chemo and Dietary Prevention Study Section, NCI, NIH, October 4-5, 2007.

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Journal Referee AAPS Journal Acta Pharmacologica Sinica Antioxidant and Redox Signaling Biochemical Pharmacology Biochimie Brain Research Breast Cancer Research Cancer Causes and Control Cancer Epidemiology, Biomarkers and Prevention Cancer Letters Cancer Research Carcinogenesis Cell Biology and Toxicology Chemico-Biological Interactions Clinical Cancer Research Comparative Biochemistry and Physiology Current Medicinal Chemistry European Journal of Cancer European J. of Cell Biology Experimental Biology and Medicine Expert Review of Anticancer Therapy-Future Drugs FEBS Letters Food and Chemical Toxicology Free Radical Biology and Medicine Gastroenterology International Journal of Cancer International Journal of Oncology International Journal of Radiation Biology Journal of Biological Chemistry Journal of Cellular Physiology Journal of Dental Research Journal of Dermatological Science Journal of the National Cancer Institute Journal of Pharmaceutical Sciences Kidney International Life Sciences Lipids Medical Research Reviews Molecular Cancer Research Molecular Cancer Therapeutics Molecular Carcinogenesis Molecular Nutrition and Food Research Molecular Pharmacology Mutation Research Neoplasia

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Nucleic Acids Research Nutrition and Cancer Oncogene Pharmaceutical Research Photochemistry and Photobiology PNAS, USA Proceeding Indian National Science Academy Skin Pharmacology The International Journal of Biochemistry The Journal of Investigative Dermatology Toxicology and Applied Pharmacology Toxicology Letters Trends in Pharmacological Sciences Urology

Editorial BoardMember, Editorial Board of Skin Pharmacology, 1995-2000.

Member, Editorial Board, Molecular Cancer Therapeutics, 2005-

Member, NCI PDQ Complementary and Alternative Medicine in Cancer Treatment (CAM) Editorial Advisory Board, 2005-

Member, Editorial Board, Clinical Medicine: Oncology, 2007-

Member, Editorial Board, International Journal in Medical Engineering and Informatics, 2007-

Member, Editorial Board, Clinical Medicine: Urology, 2007-

Member, Editorial Board, Clinical Medicine: Dermatology, 2007-

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Invited Speaker, Honors and Awards Invited talk entitled “Silibinin and Angioprevention – an upcoming strategy” at the 2nd

International Symposium on Translational Research on Natural Products and Cancer. Lonavala, Mumbai, India, December 9-12, 2007.

Key Note Address entitled “Chemoprevention of Prostate Cancer by Silibinin: Bench to Bedside” at 18th All India Congress of Zoology and SCIAZE, University of Lucknow, Lucknow, India, December 7-9, 2007.

Invited talk entitled “Lung cancer chemoprevention by silibinin” at the 9 th International Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis. Jeju Island, S. Korea, December 1-5, 2007.

Invited talk entitled “Prostate Cancer chemoprevention by silibinin: bench to bedside” at Department of Pathology, UCDHSC, Aurora, CO, October 26 th, 2007.

Co-chaired session entitled “Alternative Medicine and Cancer Chemoprevention” at 12th World Congress on Advances in Oncology and 10th International Symposium on Molecular Medicine: Bioactive Food Components, Alternative Medicine and Cancer Chemoprevention: Recent Advances. Crete, Greece, October, 2007.

Invited talk entitled “Recent advances in mechanism of cancer chemoprevention by grape seed extract” at 12th World Congress on Advances in Oncology and 10th International Symposium on Molecular Medicine: Bioactive Food Components, Alternative Medicine and Cancer Chemoprevention: Recent Advances. Crete, Greece, October, 2007.

Invited talk entitled “Dietary Supplement Milk Thistle Extract and Prostate Cancer: Mechanisms and Efficacy” at the Monthly Lecture Series of the Office of Cancer Complementary and Alternative Medicine, NCI, NIH, Bethesda, MD, May 9 th, 2007.

Shell Award Lecture entitled “Silibinin Efficacy in Cancer Models – An Update”, at Shell Prize Symposium on Cancer Chemo-Prevention, School of Pharmacy, UCDHSC, Denver, CO, March 30th, 2007.

Organizer of the Shell Prize Symposium on Cancer Chemo-Prevention, School of Pharmacy, UCDHSC, Denver, CO, March 30th, 2007.

Invited talk entitled “Molecular mechanism of prostate cancer prevention by a dietary nutrient inositol hexaphosphate” at Natural Products, Diets and Cancer Prevention Session of the American Chemical Society National Meeting, Chicago, IL. March 25th, 2007.

Invited talk entitled “Prostate cancer prevention by flavonoid silibinin” at 4 th Bio/Molecular Informatics Center International Symposium entitled “Flavonoids: old subjects but new challenges” held at Konkuk University, Seoul, Korea; February 7, 2007.

Invited talk entitled “Prostate cancer prevention by silibinin: mechanisms and efficacy” at University of Connecticut Health Sciences Center, Center for Molecular Medicine, January 24th, 2007.

Invited talk entitled “Chemoprevention of prostate cancer by silibinin” at UC Davis, December 7th, 2006.

Invited talk entitled “Prostate cancer prevention by silibinin” at The International Radiation Oncology Conference Special Session on Cancer Chemoprevention, Varanasi, India, November 20-22, 2006.

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Invited talk entitled “Molecular mechanism of prostate cancer prevention by a dietary nutrient inositol hexaphosphate” at The 3rd APOCP Conference “Empowering Cancer Prevention in the Asian Pacific”, Bangkok, Thailand, November 3-5, 2006.

Invited talk entitled “Molecular Pathways of Silibinin Efficacy against Skin Cancer” at University of Colorado Cancer Center Seminar Series, Aurora, CO, September 26 th, 2006.

Invited talk entitled “Molecular Pathways of Silibinin Efficacy against Skin Cancer” at Nelson Institute of Environmental Medicine, NYU, Tuxedo, NY, September 22nd, 2006.

Invited talk entitled “Skin Cancer Prevention by Silibinin” at 2006 International Conference Frontiers of Pharmacology and Toxicology, Chicago, IL, August 29 th, 2006.

Recipient of the 2006 Shell Award for Outstanding Achievement in Research and Graduate Education, School of Pharmacy, UCDHSC, Denver, CO.

Invited talk entitled “Molecular Mechanism of Skin Cancer Chemoprevention by Silibinin” at Division of Molecular Biology and Molecular Oncology, Evanston Northwestern Research Institute, Evanston, IL, May 9th, 2006.

Invited talk entitled “Silibinin Efficacy against Prostate Cancer: Bench to Bedside” at Karmanos Cancer Institute Grand Round Seminar Series, Detroit, MI, April 27 th, 2006.

Invited talk entitled “Cell cycle regulators are potential targets for IP6 efficacy in prostate cancer” at 2nd Developmental Therapeutics Program Retreat, UCCC, April 21st, 2006.

Invited talk entitled “Silibinin Efficacy against Prostate Cancer: Bench to Bedside” at Penn State Cancer Institute, Hershey, PA, March 16 th, 2006.

Invited talk entitled “Molecular Mechanism of Skin Cancer Chemoprevention by Silibinin” at Molecular Toxicology Seminar Series, Penn State University, University Park, PA, March 15th, 2006.

Invited talk entitled “Molecular Mechanism of Skin Cancer Prevention by an Antioxidant Flavonoid Silibinin” at Animal Cancer Center, Colorado State University, Fort Collins, January 24th, 2006.

Invited talk entitled “Molecular Mechanisms of Skin Cancer Prevention by Silibinin” at Department of Pharmacology and Toxicology, University of Alabama at Birmingham, January 17th, 2006.

Invited talk entitled “Modulation of cell cycle regulators in prostate cancer prevention by silibinin”. 3rd Joint Meeting of the Society for Free Radical Research Australia and Japan, Gold Coast, December 2-5, 2005.

Visiting Scientist, Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai, China. October 22nd-28th, 2005.

Invited talk entitled “Prostate cancer prevention by silibinin”, Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai, China. October 2005.

Invited talk entitled “Prostate cancer prevention by silibinin – bench to bedside” at Targeting Carcinogenesis, Rochester, MN, October 6th to 7th, 2005.

Invited talk entitled “IP6 prevents prostate cancer by modulating cell cycle regulators”. 24th Annual Convention of IACR, New Delhi, India, February 9-12, 2005.

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Co-chair, Nutraceuticals and Cancer II Session, at the 3rd Int. Conf. on Mechanisms of Action of Nutraceuticals, Asheville, NC, November 12-14, 2004.

Invited talk entitled “Molecular Mechanism of Silibinin Efficacy in Prostate Cancer” at the 3rd Int. Conf. on Mechanisms of Action of Nutraceuticals, Asheville, NC, November 12-14, 2004.

Co-chair, Session III at IP6 and Cell Signaling in Fighting Cancer: From Laboratory to Clinic Symposium held at the 7th International Conference of Anticancer Research, Corfu, Greece, October 25-30, 2004.

Invited talk entitled ”Prostate Cancer Prevention by IP6: Targeting Cell Cycle Regulation” at IP6 and Cell Signaling in Fighting Cancer: From Laboratory to Clinic Symposium held at the 7th International Conference of Anticancer Research, Corfu, Greece, October 25-30, 2004.

Invited talk entitled “Prostate Cancer Chemoprevention by Silibinin” at Dietary Factors and Cancer Prevention: Current Premises and Future Promises, Rochester, MN, September 23-25, 2004.

Keynote talk entitled “Dietary Agents and Cancer Prevention: How Important Are Pre-clinical Studies” at Pharmacy Student Research Conference, Western Region, Denver, CO, June, 2004.

Invited talk entitled “Targeting cell signaling and cell cycle regulators: implications in prostate cancer prevention by silibinin” at Basic Pharmaceutical Sciences Faculty Seminar, School of Pharmacy, West Virginia University, Morgantown, WV, April, 2004.

Invited talk entitled “Molecular mechanism of skin cancer prevention by an antioxidant flavonoid silibinin” at NIOSH, Morgantown, WV, April, 2004.

Co-chair, Session entitled “Prostate Cancer/Apoptosis” at 8th World Congress on Advances in Oncology, Crete, Greece, October 2003.

Invited talk entitled “Molecular Mechanism of Silibinin Efficacy in Prostate Cancer” at 8th World Congress on Advances in Oncology, Crete, Greece, October 2003.

Invited talk entitled “Prostate Cancer Prevention by Silibinin”. Hormel Institute, University of Minnesota, September 25, 2003.

Invited talk entitled “Silibinin and Prostate Cancer: Targeting EGFR”. 21st Annual Meeting of the Moutain West Society of Toxicology, Breckenridge, CO, September 18-19, 2003.

Invited talk entitled “Modulation of cell cycle regulators by silibinin in prostate cancer” at Basic Science Seminar Series, UC Cancer Center, UCHSC, Denver, CO, June 2003.

Invited talk entitled “EGFR is necessary and sufficient for silibinin efficacy: possible role in prostate cancer” at Cell Biology Program Minisymposium – Receptor Dynamics and Cancer, University of Colorado Cancer Center, UCHSC, Denver, CO, April 2003.

Invited talk on Silibinin and Prostate Cancer at Integrative Medicine Program, University of Colorado Hospital, Aurora, CO, November 2002.

Invited Speaker and Participant at 1st International Symposium on Cancer Prevention, Montreal, Canada, November 2002.

Invited talk entitled Modulation of Cell Cycle Regulators in Prostate Cancer Prevention by Silibinin at The Cell Cycle as a Target in Chemoprevention and

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Cancer Therapy Conference, 3rd International Conference, Austin, TX, October 2002.

Invited talk entitled Silibinin: preclinical antitumor activity of a natural flavanolignan at Catholic University of the Sacred Heart, sponsored by Prof. G. Scambia, Rome, Italy, July 2002.

Invited talk entitle Silibinin and Prostate Cancer, and program planning and development at Research Triangle Institute, North Carolina, April, 2002

Invited talk entitle Skin Cancer Chemoprevention by Silymarin at Basic Science Seminars, University of Colorado Cancer Center, Denver, CO, April, 2002

Invited talk entitled Silymarin and Prostate Cancer: Epigenetic Events as Molecular Targets at 1st International Conference on Mechanism of Action of Nutraceuticals, Cavtat-Dubrovnik, Croatia, October 2001.

Invited talk entitled Silymarin and Skin Cancer Prevention at College of Pharmacy, South Dakota State University, Brookings, SD, September 2001.

Talk entitled Upcoming Trial on Milk Thistle (Silymarin) at UCHSC Prostate Cancer Support Group Meeting, Denver, CO, September 2001.

Invited talk entitled Skin Cancer Chemoprevention by Silymarin at Department of Dermatology, Columbia University, New York, NY, August 2001.

Talk entitled Phytochemicals and Cancer Prevention – An Overview at DOPS, UCHSC Annual Retreat, Winter Park, CO, June 2001.

Invited Speaker at University of Illinois at Chicago, Department of Pharmaceutics and Pharmacodynamics, Chicago, IL, November 2000.

Invited Speaker at Exp. Skn Carcinogenesis: 4th International Meeting, Tucson, AZ, 2000.

Invited Speaker at University of Pittsburgh. Department of Cell Biology & Physiology, Pittsburgh, PA, October 2000.

Invited Speaker at McGill University, Montreal, Canada, October 2000. Invited Speaker at Mercy Hospital Cancer Research Institute, Pittsburgh, PA, June

2000. Inaugoral Talk at AMC Cancer Research Center 2000 – Seminar Series, January

2000. Invited Speaker at International Conference on Signal Transduction as Molecular

Targets for Therapy, Luxembourg, Luxembourg, January 2000. Invited Speaker at Univ. of Colorado Cancer Center, Denver, CO, December 1999. Invited Speaker at Department of Endocrinology, University of Colorado Health

Sciences Center, Denver, CO, December 1999. Invited Speaker at International Conference on Diet and Prevention of Cancer,

Tampere, Finland, 1999. Invited speaker at Comprehensive Cancer Center, Ohio State University, OH, 1998. Invited speaker at Exp. Skin Carcinogenesis: 3rd International Meeting, TX, 1998. My work showing exceptionally high protective effect of silymarin against

photocarcinogenesis, was covered nationally on TV, radio as well as in several magazines including CWRU Medical School’s MedLines, 1997.

Work “Anti-carcinogenic effect of a polyphenolic antioxidant silymarin in breast cancer cells MDA-MB468: a p53-independent induction of WAF1/Cip1/p21 and G1

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arrest” received an AACR-AFLAC Young Investigator Award for the 88 th Annual Meeting of AACR, 1997.

Invited speaker at MD Anderson Cancer Center, Science Park, Smithville, TX, 1996. Recipient of Upjohn Company Foundation Career Development Award through

Dermatology Foundation, 1995. Chaired an Oral Session entitled ‘Mechanism of Carcinogenesis’ at 56 th Annual

Meeting of The Society for Investigative Dermatology, 1995. Chaired an Oral Session entitled ‘UV Photobiology’ at 23rd Annual Meeting of

American Society for Photobiology, 1995. Invited speaker at Department of Dermatology, Roswell Park Cancer Center,

Buffalo, 1994. Recipient of Upjohn Company Foundation Career Development Award through

Dermatology Foundation, 1994. Recipient of Upjohn Company Foundation Career Development Award through

Dermatology Foundation, 1993. Recipient of Young Investigator Travel Award through Organizing Committee to

Attend Second Tricontinental Meeting of the JSID, SID and ESDR held at Kyoto, Japan, October 28-31, 1993.

Recipient of Lila Gruber Cancer Research Award of the American Academy of Dermatology through Dermatology Foundation, 1992.

Recipient of Robert A. Chesebrough Silver Medal from Chesebrough-Pond’s Inc. for original research work entitled “Effect of VaselineR Petroleum Jelly on absorption, tissue distribution, metabolism and DNA binding of skin carcinogen benzo(a)pyrene, 1990.

Recipient of Robert A. Chesebrough Bronze Medal from Chesebrough-Pond’s Inc. for original research paper entitled “Effect of VaselineR Petroleum Jelly on benzoyl peroxide-induced ornithine decarboxylase activity in mouse skin, 1990.

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Publications

JOURNAL PUBLICATIONSIn the Area of Bio-Organic Chemistry (1979-1989)1. Tiwari, S.S., Satsangi, R.K., and Agarwal, R.: Synthesis and CNS activity of some

2-aryl/alkyl-3-[N-phenyl, N-(dihydroxy phenylmethyl)-amino]-6, 8-disubstituted-quinazolin-4 (3H)-ones. Curr. Sci., 48:568-571, 1979.

2. Tiwari, S.S., Zaidi, S.M.M., Agarwal, R., and Satsangi, R.K.: 5-Nitro-4(2)-[4-oxo-3H-quinazolin-3yl]-benzylidene malonylureas as antibacterial agents. J. Ind. Chem. Soc., 57:1039-1040, 1980.

3. Tiwari, S.S., Agarwal, R., and Satsangi, R.K.: Synthesis and CNS activity of 1-(5’alkyl-1’,3’,4’-thiadiazol-2’-yl)-2-methyl-4-arylidene-imidazol-5 ones. J. Ind. Chem. Soc., 57:1040-1042, 1980.

4. Zaidi, S.M.M., Satsangi, R.K., Kumar, P., Nasir, M., Agarwal, R., and Tiwari, S.S.: New anti-mycobacterial hydantoins. Die Pharmazie, 35:740-741, 1980.

5. Agarwal, R., Shukla, M.K., and Satsangi, R.K.: Synthesis and CNS activity of 5-arylidene-3-arylaminomethyl-4-thiazolidinon-2-thiones. Curr. Sci., 49:455-456, 1980.

6. Agarwal, R., Satsangi, R.K., Misra, S., and Tiwari, S.S.: Synthesis and CNS activity of 2-aryl-3-(substituted-phenoxy-acetyl hydrazono)-methylenyl-indoles. Curr. Sci., 50:66-68, 1981.

7. Tiwari, S.S., Agarwal, R., and Satsangi, R.K.: Search for CNS active agents: Synthesis of N,N’-bis-[potassium-alkly/aryl-carboxylate]-5-arylidene barbituric acids. Pol. J. Pharmacol. Pharm., 33:115-120, 1981.

8. Agarwal, R., Shukla, M.K., Satsangi, R.K., and Chaudhary, C.: Synthesis of 1-{p-[3-(2’oxo/thiobenzoxazolinyl methyl)-amino] benzoyl}-4-aryl/methyl-piperazines as CNS active agents. Ind. J. Chem., 20B:680-682, 1981.

9. Agarwal, R., Satsangi, R.K., and Tiwari, S.S.: Synthesis and CNS activity of 1,5-disubstituted-3-(4’-acetamidophenoxyacetyl hydrazono) indolin-2-ones. Ind. J. Chem., 20B:1099-1100, 1981.

10.Misra, S., Satsangi, R.K., Agarwal, R., and Tiwari, S.S.: Synthesis of 2-substituted phenyl-3-aryloxyacetyl hydrazono methylenyl-indoles as central nervous system active agents. J. Chem. Soc. Pak., 3:199-202, 1981.

11.Agarwal, R., Satsangi, R.K., and Tiwari, S.S.: Chemistry and CNS activity of 1-(4-methyl-coumarin-7yl)-oxyacetyl-3-methyl-4-(substituted-phenylhydrazono/azo) pyrazolin-5-ones. J. Chem. Soc. Pak., 3:203-208, 1981.

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12.Misra, V.S., Singh, C., Agarwal, R., and Chaudhary, C.: Synthesis of 2-styryl-3,6,8-trisubstituted quinazolin-4(3H) ones as anti-inflammatory agents. J. Chem. Soc. Pak., 3:209-213, 1981.

13.Agarwal, R., Satsangi, R.K., and Tiwari, S.S.: Synthesis and CNS activities of some newer indole derivatives. J. Chem. Soc. Pak., 4:43-47, 1982.

14.Agarwal, R., Chaudhary, C., Srivastava, V.K., and Misra, V.S.: Synthesis of 1-(2-arylindol-3yl)-2-[3-(p-substituted phenyl)-6-substituted-quinazolin-4-one-2yl]-ethenes as CNS active agent. Acta Pharm. Jugosl., 32:37-44, 1982.

15.Agarwal, R., Chaudhary, C., and Misra, V.S.: Effect of mild bases on the yield of Knoevenagel products: Synthesis of some N1-substituted 4-arylidene-3-methyl-_2-pyrazolin-5-ones under different basic conditions. Ind. J. Chem., 21B:109-111, 1982.

16.Agarwal, R., Chaudhary, C., Singh, C., and Misra, V.S.: Synthesis of 2-methoxy-4(3-methyl-5-oxo 1-phenyl-4-pyrazolylidenemethyl)-phenoxyacetic acid and its ethyl ester. Ind. J. Chem., 21B:152-153, 1982.

17.Agarwal, R., Misra, S., Satsangi, R.K., and Tiwari, S.S.: Synthesis and CNS activity of N,N-disubstituted-1-(aminomethyl)-5-alkyl-3-(aryloxyacetyl hydrazono) indolin-2-ones. Arch. Pharm., 315:142-146, 1982.

18.Agarwal, R., Shukla, M.K., and Satsangi, R.K.: Synthesis and CNS activity of 4-aryl-1-p-(substituted benzamido)-piperazines. Ind. J. Pharm., 14:177-182, 1982.

19.Misra, V.S., Chaudhary, C., and Agarwal, R.: Synthesis of N1-(2,4-dinitrophenyl acetyl)-3-methyl-4-(substituted phenyl-hydrazono/azo)-pyrazolin-5-ones. Ind. J. Chem., 21B:466-467, 1982.

20. Singh, C., Agarwal, R., Chaudhary, C., and Misra, V.S.: Synthesis of 1-(N,N-disubstituted-aminomethyl)-2-oxo-3-(2,4-dinitrophenylacetyl hydrazono)-5-substituted-indoles as anti-inflammatory agents. J. Chem. Soc. Pak., 4:215-219, 1982

21.Agarwal, R., Chaudhary, C., and Misra, V.S.: Synthesis and CNS activity of 4-arylideneamino-N,N-diphenylbenzamides, 1-[p-(N,N diphenylcarbamoyl) phenyl]-3-(p-substituted phenyl) thioureas and 6-substituted 3-[N-(3H-2-methyl-4-oxo-3-quinazolylamino)methyl] 2-oxo/thio-benzoxazoles. Ind. J. Chem., 21B:1110-1113, 1982.

22.Chaudhary, C., Agarwal, R., and Misra, V.S.: Synthesis of 2-aryl-3-(3-disubstituted aminomethyl-2-thio-4-oxo-thiazolidin-5yl)-methylenyl-indoles as CNS active agents. Proc. Ind. Acad. Sci., 91:483-489, 1982.

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23.Agarwal, R., Chaudhary, C., and Misra, V.S.: Synthesis of 2-aryl-1-(4-morpholinophenyl)-4-(3,4-disubstituted-benzylidene) imidazolin-5-ones as CNS active agents. Ind. J. Chem., 22B:308-310, 1983.

24.Singh, C., Agarwal, R., and Misra, V.S.: Synthesis of 2-thio 3-arylamino/ disubstituted amino-methyl-4-oxo-5-cinnamylidene-thiazolidines as CNS and anti-inflammatory agents. Curr. Sci., 52:305-308, 1983.

25.Mohan, R.R., Agarwal, R., and Misra, V.S.: Synthesis and pharmacological screening of 2-thio-3-arylaminomethyl-4-oxo-5-(3,4-disubstituted benzylidene) thiazolidines. Indian Drugs, 21:90-95, 1983.

26.Agarwal, C., Agarwal, R., Gupta, P.N., Srivastava, V.K., and Misra, V.S.: Synthesis of 1-dialkylaminomethyl-2-oxo-3-(3’-cyclohexylpropanonyl) hydrazono-5-substituted indoles as possible psychotropic agents. Acta Pharm. Jugosl., 33:183-192, 1983.

27.Mohan, R.R., Agarwal, C., Agarwal, R., and Misra, V.S.: CNS, anthelmintic and anti-inflammatory activities of some 1-[2/3-(2-phenyl benzimidazole] 2-methyl/phenyl-4 (3,4-disubstituted benzylidene) 5-oxo-imidazoles. Pharm. Res. Comm., 16:321-338, 1984.

28.Agarwal, R., Agarwal, C., Singh, C., and Misra, V.S.: Synthesis of 1-(2-arylindol-3yl)- 2[3-(p-morpholinophenyl)- 6,8-disubstituted-quinazolin- 4(3H)- one-2yl] ethenes as CNS active and anti-inflammatory agents. J. Chem. Soc. Pak., 6:89-94, 1984.

29.Agarwal, R., Agarwal, C., and Kumar, P.: Antitubercular and CNS activities of some 2-aryl-3- [N-(2/3/4-benzimidazol-2yl)phenyl]- iminomethylenyl-indoles. Pharm. Res. Comm., 16:831-844, 1984.

30.Mohan, R.R., Agarwal, R., and Misra, V.S.: Synthesis of some newer quinazolinyl-oxadiazoles, thiosemicarbazides and thiadiazoles as pharmacologically active agents. Ind. J. Chem., 24B:78-82, 1985.

31.Mohan, R.R., Agarwal, R., and Misra, V.S.: Synthesis of 2/9-substituted indophenazin-6-acetic acid -aryl/methyl benzylidene hydrazides, 4-aryl-1-(indophenazin-6-methylcarbonyl)-3-thiosemicarbazides and 6-(4-aryl-5-mercapto-4H-1,2,4-triazol-3yl methyl) indophenazines as CNS active and anti-inflammatory agents. Ind. J. Chem., 25B:1234-1237, 1986.

32.Agarwal, R., Bhargava, S.K., Kidwai, M.M., Mehrotra, N.K., and Lal, M.M.: Estimation of benzo(a)pyrene in ambient air of different areas of Lucknow city. Proceedings of National Symposium on chemical carcinogenesis and carcinogens in the environment. 136-138, 1988.

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33.Agarwal, R., Agarwal, C., Singh, C., Mohan, R.R., and Misra, V.S.: Synthesis of 6-substituted indophenazines as possible psychotropic and anti-inflammatory agents. Acta Pharm. Jugosl., 38:11-21, 1988.

34.Agarwal, R., Singh, C., and Misra, V.S.: CNS and anti-inflammatory activities of some newer oxo-imidazolidenes. Indian Drugs, 25:185-190, 1988.

35.Agarwal, R., Agarwal, C., Singh, C., and Misra, V.S.: Synthesis of 1-substituted-2-oxo-3-chloro/(2-chlorophenoxy)-4-(2 arylindol-3yl) azetidines as CNS active and antiinflammatory agents. Ind. J. Chem., 28B:893-896, 1989.

In the Areas of Biological Sciences and Cancer Biology/Pharmacology(1985 to date)36.Agarwal, R., Kumar, S., Shukla, Y., Antony, M., and Mehrotra, N.K.: Quantification

of tumour initiating effect of Jute Batching Oil and its distillates over mouse skin. Cancer Lett., 28:281-290, 1985.

37.Agarwal, R., Kumar, S., and Mehrotra, N.K.: Polyaromatic hydrocarbon profile of a mineral oil (JBO-P) by gas chromatography. J. Chrom. Sci., 24:289-292, 1986.

38.Agarwal, R., Gupta, K.P., Kumar, S., and Mehrotra, N.K.: Assessment of some tumourigenic risks associated with fresh and used cutting oil. Ind. J. Exptl. Biol., 24:508-510, 1986.

39.Mehrotra, N.K., Kumar, S., Agarwal, R., and Antony, M.: Jute Batching oil: a tumor promoter on mouse skin. Environ. Res., 42:12-23, 1987.

40.Agarwal, R., Shukla, Y., Kumar, S., and Mehrotra, N.K.: Evaluation of carcinogenic effect of jute batching oil (JBO-P) fractions following topical application to mouse skin. Arch. Toxicol., 62:406-410, 1988.

41.Rajasekharan, K.N., Mayadevi, M., Agarwal, R., and Burke, M.: MgADP-induced changes in the structure of myosin S1 near the ATPase-related thiol SH1 probed by cross-linking. Biochemistry, 29:3006-3013, 1990.

42.Agarwal, R., Athar, M., Bickers, D.R., and Mukhtar, H.: Evidence for the involvement of singlet oxygen in the photodestruction by chloroaluminum phthalocyanine tetrasulfonate. Biochem. Biophys. Res. Commun., 173:34-41, 1990.

43.Agarwal, R., Rajasekharan, K.N. and Burke, M.: Identification of the site of photocross-linking formed in the absence of magnesium nucleotide from SH2 (cys-697) in myosin subfragment 1 labeled with 4’-maleimidylbenzophenone. J. Biol. Chem., 266:2272-2275, 1991.

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44.Wang, Z.Y., Agarwal, R., Zhou, Z.C., Bickers, D.R. and Mukhtar, H.: Inhibition of mutagenicity in Salmonella typhimurium and skin tumor initiating and tumor promoting activities in Sencar mice by glycyrrhetinic acid: Comparison of 18- and 18-stereoisomers. Carcinogenesis, 12:187-192, 1991.

45. Agarwal, R., Athar, M., Urban, S.A., Bickers, D.R., and Mukhtar, H.: Involvement of singlet oxygen in chloroaluminum phthalocyanine tetrasulfonate-mediated photoenhancement of lipid peroxidation in rat epidermal microsomes. Cancer Lett., 56:125-129, 1991.

46. Agarwal, R., Wang, Z.Y., and Mukhtar, H.: Inhibition of skin tumor initiating activity of DMBA by chronic oral feeding of glycyrrhizin in drinking water. Nutrition and Cancer, 15:187-193, 1991.

47. Agarwal, R., Wang, Z.Y., Bik, D.P., and Mukhtar, H.: Nordihydroguaiaretic acid, an inhibitor of lipoxygenase, also inhibits cytochrome P 450-mediated monooxygenase activity in rat epidermal and hepatic microsomes. Drug Metab. Dispos., 19:620-624, 1991.

48. Wang, Z.Y., Agarwal, R., Bickers, D.R., and Mukhtar, H.: Protection against ultraviolet B radiation-induced photocarcinogenesis in hairless mice by green tea polyphenols. Carcinogenesis, 12:1527-1530, 1991.

49. Agarwal, R. and Burke, M.: Temperature induced changes in the flexibility of the loop between SH1 (cys-707) and SH3 (cys-522) in myosin subfragment 1 detected by cross-linking. Arch. Biochem. Biophys., 290:1-6, 1991.

50. Agarwal, R., Medrano, E.E., Khan, I.U., Nordlund, J.J. and Mukhtar, H.: Metabolism of benzo(a)pyrene by human melanocytes in culture. Carcinogenesis, 12:1963-1966, 1991.

51. Wang, Z.Y., Agarwal, R., Zhou, Z.C., Bickers, D.R. and Mukhtar, H.: Antimutagenic and antitumorigenic activities of nordihydroguaiaretic acid. Mutation Res., 261:153-162, 1991.

52. Athar, M., Agarwal, R., Wang, Z.Y., Lloyd, J.R., Bickers, D.R. and Mukhtar, H.: All trans retinoic acid protects against conversion of chemically induced- and ultraviolet B radiation-induced skin papillomas to carcinomas. Carcinogenesis, 12:2325-2329, 1991.

53. Mukhtar, H., Agarwal, R., Athar, M., Lewen, R.L., Elmets, C.A., and Bickers, D.R.: Photodynamic therapy of murine skin tumors by Photofrin II. Photodermatol. Photoimmunol. Photomed., 8:169-175, 1991.

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54. Raza, H., Agarwal, R., Bickers, D.R., and Mukhtar, H.: Purification and molecular characterization of -naphthoflavone- inducible cytochrome P-450 from rat epidermis. J. Invest. Dermatol., 98:233-240, 1992.

55. Agarwal, R., Zaidi, S.I.A., Athar, M., Bickers, D.R. and Mukhtar, H.: Photodynamic effects of chloroaluminum phthalocyanine tetrasulfonate are mediated by singlet oxygen: in vivo and in vitro studies utilizing hepatic microsomes as model membrane source. Arch. Biochem. Biophys., 294:30-37, 1992.

56. Mukhtar, H., Wang, Z.Y., Katiyar, S.K. and Agarwal, R.: Tea components: Antimutagenic and anticarcinogenic effects. Preventive Medicine, 21:351-360, 1992.

57. Agarwal, R., Katiyar, S.K., Zaidi, S.I.A. and Mukhtar, H.: Inhibition of skin tumor promoter-caused induction of epidermal ornithine decarboxylase in SENCAR mice by polyphenolic fraction isolated from green tea and its individual epicatechin derivatives. Cancer Res., 52:3582-3588, 1992.

58. Agarwal, R., Athar, M., Elmets, C.A., Bickers, D.R. and Mukhtar, H.: Photodynamic therapy of chemically- and ultraviolet B radiation-induced murine skin papillomas by chloroaluminum phthalocyanine tetrasulfonate. Photochem. Photobiol., 56:43-50, 1992.

59. Khan, S.G., Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention. Cancer Res., 52:4050-4052, 1992.

60. Wang, Z.Y., Agarwal, R., Khan, W.A. and Mukhtar, H.: Protection against benzo(a)pyrene and N-nitrosodiethylamine-induced lung and forestomach tumorigenesis in A/J mice by water extracts of green tea and licorice. Carcinogenesis, 13:1491-1494, 1992.

61. Katiyar, S.K., Agarwal, R., Wang, Z.Y., Bhatia, A.K. and Mukhtar, H.: (-)-Epigallocatechin-3-gallate in Camellia sinensis leaves from Himalayan region of Sikkim: Inhibitory effects against biochemical events and tumor initiation in SENCAR mouse skin. Nutrition and Cancer, 18:73-83, 1992.

62. Agarwal, R., Raza, H., Allyn, D.L., Bickers, D.R. and Mukhtar, H.: Glutathione S-transferase dependent conjugation of leukotriene A4 methyl ester to leukotriene C4 methyl ester in mammalian skin. Biochem. Pharmacol., 44:2047-2053, 1992.

63. Katiyar, S.K., Agarwal, R., Wood, G.S. and Mukhtar, H.: Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in 7,12-

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dimethylbenz[a]anthracene-initiated SENCAR mouse skin by a polyphenolic fraction isolated from green tea. Cancer Res., 52:6890-6897, 1992.

64. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Green tea in chemoprevention of cancer. Comprehensive Therapy, 18:3-8, 1992.

65. Katiyar, S.K., Agarwal, R., Ekker, S., Wood, G.S. and Mukhtar, H.: Protection against 12-O-tetradecanoylphorbol-13-acetate-caused inflammation in SENCAR mouse ear skin by polyphenolic fraction isolated from green tea. Carcinogenesis, 14:361-365, 1993.

66. Katiyar, S.K., Agarwal, R., Zaim, M.T. and Mukhtar, H.: Protection against N-nitrosodiethylamine and benzo(a)pyrene-induced forestomach and lung tumorigenesis in A/J mice by green tea. Carcinogenesis, 14:849-855, 1993.

67. Sutter, C., Strickland, P.T., Mukhtar, H., Agarwal, R., Winter, H. and Schweizer, J.: Ras gene activation and aberrant expression of keratin K13 in ultraviolet B radiation- induced epidermal neoplasias of mouse skin. Mol. Carcinogenesis, 8:13-19, 1993.

68. Zaidi, S.I.A., Agarwal, R., Eichler, G., Rihter, B.D., Kenney, M.E. and Mukhtar, H.: Photodynamic effects of new silicon phthalocyanines: in vitro studies utilizing rat hepatic microsomes and human erythrocyte ghosts as model membrane sources. Photochem. Photobiol., 58:204-210, 1993.

69. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Protection against malignant conversion of chemically-induced benign skin papillomas to squamous cell carcinomas in SENCAR mice by a polyphenolic fraction isolated from green tea. Cancer Res., 53:5409-5412, 1993.

70. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Protective effects of green tea polyphenols administered by oral intubation against chemical carcinogen-induced forestomach and pulmonary neoplasia in A/J mice. Cancer Letters, 73:167-172, 1993.

71. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of both stage I and stage II skin tumor promotion in SENCAR mice by a polyphenolic fraction isolated from green tea: Inhibition depends on the duration of polyphenol treatment. Carcinogenesis, 14:2641-2643, 1993.

72. Agarwal, R., Katiyar, S.K., Khan, S.G. and Mukhtar, H.: Protection against ultraviolet B radiation-induced effects in the skin of SKH-1 hairless mice by a polyphenolic fraction isolated from green tea. Photochem. Photobiol., 58: 695-700, 1993.

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73. Agarwal, R., Khan, S.G., Athar, M., Zaidi, S.I.A., Bickers, D.R. and Mukhtar, H.: Ras protein p21 processing enzyme farnesyltransferase in chemical carcinogen-induced murine skin tumors. Mol. Carcinogenesis, 8:290-298, 1993.

74. Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Green tea and skin - anticarcinogenic effects. J. Invest. Dermatol., 102:3-7, 1994.

75. Agarwal, R., Jugert, F.K., Khan, S.G., Bickers, D.R., Merk, H.F. and Mukhtar, H.: Evidence for multiple inducible cytochrome P450 isozymes in SENCAR mouse skin by pyridine. Biochem. Biophys. Res. Commun., 199:1400-1406, 1994.

76. Khan, S.G., Bickers, D.R., Mukhtar, H. and Agarwal, R.: Ras p21 farnesylation in ultraviolet B radiation-induced tumors in the skin of SKH-1 hairless mice. J. Invest. Dermatol., 102:754-758, 1994.

77. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of spontaneous and photo-enhanced lipid peroxidation in mouse epidermal microsomes by epicatechin derivatives from green tea. Cancer Lett., 79:61-66, 1994.

78. Jugert, F.K., Agarwal, R., Kuhn, A., Bickers, D.R., Merk, H.F. and Mukhtar, H.: Multiple cytochrome P450 isozymes in murine skin: Induction of P450 1A, 2B, 2E and 3A by dexamethasone. J. Invest. Dermatol., 102:970-975, 1994.

79. Agarwal, R., Katiyar, S.K., Lundgren, D.W. and Mukhtar, H.: Inhibitory effect of silymarin, an anti-hepatotoxic flavonoid, on 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity and mRNA in SENCAR mice. Carcinogenesis, 15:1099-1103, 1994.

80. Mukhtar, H., Zaidi, S.I.A., Raza, H. and Agarwal, R.: Differential expression of glutathione S-transferase isozymes in murine and human skin tumors. Int. J. Oncology, 6:37-43, 1995.

81. Khan, S.G., Saxena, R., Bickers, D.R., Mukhtar, H. and Agarwal, R.: Inhibition of ras p21 membrane localization and modulation of protein kinase C isozyme expression during regression of chemical carcinogen-induced murine skin tumors by lovastatin. Mol. Carcinogenesis, 12:205-212, 1995.

82. Khan, S.G., Mukhtar, H. and Agarwal, R.: A rapid and convenient filter-binding assay for ras p21 processing enzyme farnesyltransferase. J. Biochem. Biophys. Methods, 30:133-144, 1995.

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83. Agarwal, R. and Mukhtar, H.: Cancer chemoprevention by polyphenolic compounds present in green tea. Drug News & Perspective, 8:216-225, 1995.

84. Katiyar, S.K., Rupp, C.O., Korman, N.J., Agarwal, R. and Mukhtar, H.: Inhibition of 12-O-tetradecanoylphorbol-13-acetate and other skin tumor promoter-caused induction of epidermal interleukin-1 mRNA and protein expression in SENCAR mice by green tea polyphenols. J. Invest. Dermatol., 105:394-398, 1995.

85. Katiyar, S.K., Elmets, C.A., Agarwal, R. and Mukhtar, H.: Protection against ultraviolet B radiation-induced local and systemic suppression of contact hypersensitivity and edema responses in C3H/HeN mice by green tea polyphenols. Photochem. Photobiol., 62:855-861, 1995.

86. Khan, S.G., Mohan, R.R., Katiyar, S.K., Wood, G.S., Bickers, D.R., Mukhtar, H. and Agarwal, R.: Mutations in ras oncogenes: Rare event in ultraviolet B radiation-induced mouse skin tumorigenesis. Mol. Carcinogenesis, 15:96-103, 1996.

87. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of tumor promotion in SENCAR mouse skin by ethanol extract of Gingiber officinale rhizome. Cancer Res., 56:1023-1030, 1996.

88. Agarwal, R. and Mukhtar, H.: Chemoprevention of photocarcinogenesis. Photochem. Photobiol., 63:440-444, 1996.

89. Agarwal, R., Korman, N.J., Mohan, R.R., Jawed, S., Zaim, M.T. and Mukhtar, H.: Apoptosis is an early event during phthalocyanine-photodynamic therapy-induced ablation of murine skin tumors. Photochem. Photobiol., 63:547-552, 1996.

90. Khan, S.G., Dummer, R., Siddiqui, J, Bickers, D.R., Agarwal, R. and Mukhtar, H.: Farnesyltransferase activity and mRNA expression in human skin basal cell carcinomas. Biochem. Biophys. Res. Commun., 220:795-801, 1996.

91. Mohan, R.R., Katiyar, S.K., Khan, S.G., Zaim, M.T., Mukhtar, H. and Agarwal, R.: Protective effect of all trans retinoic acid against tumor promotion and progression in low- and high-risk protocols of mouse skin chemical carcinogenesis. Int. J. Oncology, 8:1079-1088, 1996.

92. Mukhtar, H. and Agarwal, R.: Skin cancer chemoprevention. J. Invest. Dermatol. Symposium Proceedings, 1:209-214, 1996.

93. Agarwal, R., Mohan, R.R., Ahmad, N. and Mukhtar, H.: Protection against malignant conversion in SENCAR mouse skin by all trans retinoic

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acid: Inhibition of the ras p21-processing enzyme farnesyltransferase and Ha-ras p21 membrane localization. Mol. Carcinogenesis, 17:13-22, 1996.

94. Ahmad, N., Agarwal, R. and Mukhtar, H.: Cytochrome P450-dependent drug metabolism in skin. Clinics in Dermatol., 14:407-415, 1996.

95. Singh, S.V., Mohan, R.R., Agarwal, R., Benson, P.J., Hu, X., Rudy, M.A., Xia, H., Katoh, A., Srivastava, S.K., Mukhtar, H., Gupta, V. and Zaren, H.A.: A novel anti-carcinogenic activity of an organosulfide from garlic: Inhibition of H-ras oncogene transformed tumor growth in vivo by diallyl disulfide is associated with inhibition of p21H-ras processing. Biochem. Biophys. Res. Commun., 225:660-665, 1996.

96. Chatterjee, M.L., Agarwal, R. and Mukhtar, H.: Ultraviolet B radiation-induced DNA lesions in mouse epidermis: an assessment using a novel 32P-postlabelling technique. Biochem. Biophys. Res. Commun., 229:590-595, 1996.

97. Ahmad, N., Agarwal, R. and Mukhtar, H.: Cytochrome P450 and drug development for skin diseases. Skin Pharmacol., 9:231-241, 1996.

98. Katiyar, S.K., Mohan, R.R., Agarwal, R. and Mukhtar, H.: Protection against induction of mouse skin papillomas with low- and high-risk for conversion to malignancy by green tea polyphenols. Carcinogenesis, 18:497-502, 1997.

99. Ahmad, N., Srivastava, R.C., Agarwal, R. and Mukhtar, H.: Nitric oxide synthase and skin tumor promotion. Biochem. Biophys. Res. Commun., 232:328-331, 1997.

100. Katiyar, S.K., Korman, N.J., Mukhtar, H. and Agarwal, R.: Protective effects of silymarin against photocarcinogenesis in mouse skin model. J. Natl. Cancer Inst., 89: 556-566, 1997.

101. Srivastava, S.K., Hu, X., Xia, H., Zaren, H.A., Chatterjee, M.L., Agarwal, R. and Singh, S.V.: Mechanism of differential efficacy of organosulfides in preventing benzo(a)pyrene-induced cancer in mice. Cancer Lett., 118: 61-67, 1997.

102. Ahmad, N., Feyes, D.K., Nieminen, A.-L., Agarwal, R. and Mukhtar, H.: Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells. J. Natl. Cancer Inst., 89:1881-1886, 1997.

103. Zi, X., Mukhtar, H. and Agarwal, R.: Novel cancer chemopreventive effects of a flavonoid antioxidant silymarin: Inhibition of mRNA expression of an endogenous tumor promoter TNF. Biochem. Biophys. Res. Commun., 239: 334-339, 1997.

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104. Zi, X., Feyes, D.K. and Agarwal, R.: Anti-carcinogenic effect of a flavonoid antioxidant silymarin in human breast cancer cells MDA-MB 468: Induction of G1 arrest through an increase in Cip1/p21 concomitant with a decrease in kinase activity of CDKs and associated cyclins. Clin. Cancer Res., 4: 1055-1064, 1998.

105. Zi, X., Grasso, A.W., Kung, H.-J. and Agarwal, R.: A flavonoid antioxidant silymarin inhibits activation of erbB1 signaling, and induces cyclin-dependent kinase inhibitors, G1 arrest and anti-carcinogenic effects in human prostate carcinoma DU145 cells. Cancer Res., 58: 1920-1929, 1998.

106. Ahmad, N., Gali, H., Javed, S. and Agarwal, R.: Skin cancer chemopreventive effects of a flavonoid antioxidant silymarin are mediated via impairment of receptor tyrosine kinase signaling and perturbation in cell cycle progression. Biochem. Biophys. Res. Commun., 247: 294-301, 1998.

107. Ahmad, N., Feyes, D.K., Agarwal, R. and Mukhtar, H.: Photodynamic therapy results in induction of WAF1/CIP1/P21 leading to cell cycle arrest and apoptosis. Proc. Natl. Aca. Sci. USA, 95: 6977-6982, 1998.

108. Mohan, R.R., Challa, A., Gupta, S., Bostwick, D.G., Ahmad, N., Agarwal, R., Marengo, S.R., Amini, S.B., MacLennan, G.T., Paras, F., Resnick, M.I. and Mukhtar, H.: Overexpression of ornithine decarboxylase in prostate cancer and prostatic fluid in humans. Clin. Cancer Res., 5:143-147, 1999.

109. Lahiri-Chatterjee, M., Katiyar, S.K., Mohan, R.R. and Agarwal, R.: A flavonoid antioxidant, silymarin, affords exceptionally high protection against tumor promotion in SENCAR mouse skin tumorigenesis model. Cancer Res., 59:622-632, 1999.

110. Zi, X. and Agarwal, R.: Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: Implications for prostate cancer intervention. Proc. Natl. Acad. Sci. USA, 96:7490-7495, 1999.

111. Zhao, J., Wang, J., Chen, Y. and Agarwal, R.: Anti-tumor promoting activity of a polyphenolic fraction isolated from grape seeds in mouse skin two-stage initiation-promotion protocol, and identification of procyanidin B5-3’-gallate as the most effective antioxidant constituent. Carcinogenesis, 20:1737-1745, 1999.

112. Zhao, J. and Agarwal, R.: Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: Implications in cancer chemoprevention. Carcinogenesis, 20: 2101-2108, 1999.

113. Bhatia, N., Zhao, J., Wolf, D.M. and Agarwal, R.: Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: comparison with silymarin. Cancer Letts., 147: 77-84, 1999.

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114. Zi, X. and Agarwal, R.: Modulation of mitogen-activated protein kinase activation and cell cycle regulators by the potent skin cancer preventive agent silymarin. Biochem. Biophys. Res. Commun., 263: 528-536, 1999.

115. Zhao, J., Sharma, Y. and Agarwal, R.: Significant inhibition by the flavonoid antioxidant silymarin against 12-O-tetradecanoylphorbol 13-acetate-caused modulation of antioxidant and inflammatory enzymes, and cyclooxygenase 2 and interlukin-1 expression in SENCAR mouse epidermis: implications in the prevention of stage I tumor promotion. Mol. Carcinogenesis, 26: 321-333, 1999.

116. Zhao, J., Lahiri-Chatterjee, M., Sharma, Y. and Agarwal, R.: Inhibitory effect of a flavonoid antioxidant silymarin on benzoyl peroxide-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin. Carcinogenesis, 21: 811-816, 2000.

117. Agarwal, C., Sharma, Y., Zhao, J. and Agarwal, R.: A polyphenolic fraction from grape seeds causes irreversible growth inhibition of breast carcinoma MDA-MB468 cells by inhibiting mitogen-activated protein kinases activation and inducing G1 arrest and differentiation. Clinical Cancer Res., 6: 2921-2930, 2000.

118. Agarwal, C., Sharma, Y. and Agarwal, R.: Anticarcinogenic effect of a polyphenolic fraction isolated from grape seeds in human prostate carcinoma DU145 cells: modulation of mitogenic signaling and cell cycle regulators and induction of G1 arrest and apoptosis. Mol. Carcinogenesis, 28: 129-138, 2000.

119. Jiang, C., Agarwal, R. and Lu, J.: Anti-angiogenic potential of silymarin: inhibition of key attributes of vascular endothelial cells and angiogenic cytokine secretion by cancer epithelial cells. Biochem. Biophys. Res. Commun., 276: 371-378, 2000.

120. Zi, X, Zhang, J., Agarwal, R. and Pollak, M.: Silibinin up-regulates insulin-like growth factor-binding protein 3 expression and inhibits proliferation of androgen-independent prostate cancer cells. Cancer Res. (Advances in Brief), 60: 5617-5620, 2000.

121. Agarwal, R.: Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents. Biochemical Pharmacol., 60: 1051-1059, 2000.

122. Zi, X., Singh, Rana P. and Agarwal, R.: Impairment of erbB1 receptor and fluid-phase endocytosis and associated mitogenic signaling by inositol hexaphosphate in human prostate carcinoma DU145 cells. Carcinogenesis, 21: 2225-2235, 2000.

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123. Bhatia, N. and Agarwal, R.: Detrimental effect of cancer preventive phytochemicals silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human prostate carcinoma DU145 cells. Prostate, 46: 98-107, 2001.

124. Sharma, Y., Agarwal, C., Singh, A.K. and Agarwal, R.: Inhibitory effect of silibinin on ligand binding to erbB1 and associated mitogenic signaling, growth, and DNA synthesis in advanced human prostate carcinoma cells. Mol. Carcinogenesis, 30: 224-236, 2001.

125. Bhatia, N., Agarwal, C. and Agarwal, R.: Differential response of skin cancer chemopreventive agent silibinin, quercetin and epigallocatechin 3-gallate on mitogenic signaling and cell cycle regulators in human epidermoid carcinoma A431 cells. Nutrition and Cancer, 39: 292-299, 2001.

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After Joining DOPS, SOP, UCHSC126. Dhanalakshmi, S., Singh, R.P., Agarwal, C and Agarwal, R.: Silibinin inhibits

constitutive and TNF-induced activation of NF-B and sensitizes human prostate carcinoma DU145 cells to TNF-induced apoptosis. Oncogene, 21: 1759-1767, 2002.

127. Tyagi, A., Agarwal, C. and Agarwal, R.: The cancer preventive flavonoid silibinin causes hypophosphorylation of Rb/p107and Rb2/p130 via modulation of cell cycle regulators in human prostate carcinoma DU145 cells. Cell Cycle, 1: 137-142, 2002.

128. Singh, R.P., Tyagi, A.K., Zhao, J. and Agarwal, R.: Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis. Carcinogenesis, 23: 499-510, 2002.

129. Tyagi, A., Agarwal, C. and Agarwal, R.: Inhibition of Rb phosphorylation at serine sites and an increase in Rb-E2F complex formation by silibinin in androgen-dependent human prostate carcinoma LNCaP cells: role in prostate cancer prevention. Molecular Cancer Therapeutics, 1: 525-532, 2002.

130. Singh, R.P., Dhanalakshmi, S., Tyagi, A.K., Chan, D.C.F., Agarwal, C. and Agarwal, R.: Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice, and increases plasma insulin-like growth factor-binding protein-3 levels. Cancer Res., 62: 3063-3069, 2002.

131. Singh, R.P., Dhanalakshmi, S. and Agarwal, R.: Phytochemicals as cell cycle modulators: a less toxic approach in halting human cancers. Cell Cycle, 1: 156-161, 2002.

132. Singh, R.P. and Agarwal, R.: Flavonoid antioxidant silymarin and skin cancer. Antioxidants & Redox Signaling, 4: 655-663, 2002.

133. Tyagi, A., Bhatia, N., Condon, M.S., Bosland, M.C., Agarwal, C. and Agarwal, R.: Anti-proliferative and apoptotic effects of silibinin in rat prostate cancer cells. Prostate, 53: 211-217, 2002.

134. Jiang, W., Zhu, Z., Bhatia, N., Agarwal, R. and Thompson, H.J.: Mechanisms of energy restriction: effects of corticosterone on cell growth, cell cycle machinery and apoptosis. Cancer Res., 62: 5280-5287, 2002.

135. Tyagi, A.K., Singh, R.P., Agarwal, C., Chan, D.C.F. and Agarwal, R.: Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth inhibition, G2-M arrest and apoptosis. Clin. Cancer Res., 8: 3512-3519, 2002. (Selected for the commentary – The Biology Behind by Robert S. DiPaola “To arrest or not to G2-M cell cycle arrest, Clin. Cancer Res., 8: 3311-3314, 2002).

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136. Agarwal, C., Singh, R.P. and Agarwal, R.: Grape seed extract inhibits growth and induces apoptotic death of prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release. Carcinogenesis, 23: 1869-1876, 2002.

137. Tyagi, A., Agarwal, R. and Agarwal, C.: Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis. Oncogene, 22: 1302-1316, 2003.

138. Singh, R.P., Agarwal, C. and Agarwal, R.: Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes. Carcinogenesis, 24: 555-563, 2003.

139. Singh, R.P. and Agarwal, R.: Tumor angiogenesis: a potential target in cancer control by phytochemicals. Current Cancer Drug Targets, 3: 203-215, 2003.

140. Singh, R.P. and Agarwal, R.: Prostate cancer prevention by silibinin. Current Cancer Drug Targets, 4: 1-11, 2004.

141. Dhanalakshmi, S., Agarwal, P., Glode, L.M. and Agarwal, R.: Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatin- and carboplatin-induced growth inhibition and apoptotic death. Int. J. Cancer, 106: 699-705, 2003.

142. Sharma, G., Singh, R.P., Chan, D.C.F. and Agarwal, R.: Silibinin induces growth inhibition and apoptotic cell death in human lung carcinoma cells. Anticancer Res., 23: 2649-2655, 2003.

143. Dhanalakshmi, S., Agarwal, R. and Agarwal, C.: Inhibition of NF-kB pathway in grape seed extract-induced apoptotic death of human prostate carcinoma DU145 cells. Int. J. Oncology, 23: 721-727, 2003.

144. Singh, R.P., Sharma, G., Dhanalakshmi, S., Agarwal, C. and Agarwal, R.: Suppression of advanced human prostate tumor growth in nude mice by silibinin feeding is associated with reduced cell proliferation, increased apoptosis, and inhibition of angiogenesis. Cancer Epidemiology, Biomarkers & Prevention, 12: 933-939, 2003.

145. Qi, L., Singh, R.P., Lu, Y., Agarwal, R., Harrison, G.S., Franzusoff, A. and Glode, L.M.: Epidermal growth factor receptor mediates silibinin-induced cytotoxicity in a rat glioma cell line. Cancer Biology and Therapy, 2: 526-531, 2003.

146. Agarwal, C., Dhanalakshmi, S., Singh, R.P. and Agarwal, R.: Inositol hexaphosphate inhibits constitutive activation of NF-B in androgen-independent human prostate carcinoma DU145 cells. Anticancer Res., 23: 3855-3862, 2003.

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147. Sharma, G., Singh, R.P. and Agarwal, R.: Growth inhibitory and apoptotic effects of inositol hexaphosphate in transgenic adenocarcinoma of mouse prostate (TRAMP-C1) cells. Int. J. Oncology, 23: 1413-1418, 2003.

148. Agarwal, C., Singh, R.P., Dhanalakshmi, S., Tyagi, A.K., Tecklenburg, M., Sclafani, R.A. and Agarwal, R.: Silibinin up-regulates the expression of cyclin-dependent kinase inhibitors, and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. Oncogene, 22: 8271-8282, 2003.

149. Tyagi, A.K., Agarwal, C., Singh, R.P., Shroyer, K.R., Glode, L.M. and Agarwal, R.: Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells. Biochem. Biophys. Res. Commun., 312: 1178-1184, 2003.

150. Dhanalakshmi, S., Mallikarjuna, G.U., Singh, R.P. and Agarwal, R.: Dual-efficacy of silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in human immortalized keratinocyte HaCaT cells. Carcinogenesis, 25: 99-106, 2004.

151. Singh, R.P., Tyagi, A.K., Dhanalakshmi, S., Agarwal, R. and Agarwal, C.: Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis, and up-regulates insulin-like growth factor binding protein-3. Int. J. Cancer, 108: 733-740, 2004.

152. Singh, R.P., Sharma, G., Mallikarjuna, G.U., Dhanalakshmi, S., Agarwal, C. and Agarwal, R.: In vivo suppression of hormone-refractory prostate cancer growth by inositol hexaphosphate: induction of insulin-like growth factor binding protein-3 and inhibition of vascular endothelial growth factor. Clinical Cancer Res., 10: 244-250, 2004.

153. Sharma, G., Tyagi, A.K., Singh, R.P., Chan, D.C.F. and Agarwal, R.: Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells. Breast Cancer Res. Treatment, 85: 1-12, 2004.

154. Tyagi, A.K., Agarwal, C., Chan, D.C.F. and Agarwal, R.: Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells. Oncology Reports, 11: 493-499, 2004.

155. Agarwal, C., Singh, R.P., Dhanalakshmi, S. and Agarwal, R.: Anti-angiogenic efficacy of grape seed extract in endothelial cells. Oncology Reports, 11: 681-685, 2004.

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156. Dhanalakshmi, S., Mallikarjuna, G.U., Singh, R.P. and Agarwal, R.: Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis. Carcinogenesis, 25: 1459-1465, 2004.

157. Tyagi, A., Agarwal, C., Harrison, G., Glode, L.M. and Agarwal, R.: Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages. Carcinogenesis, 25: 1711-1720, 2004.

158. Agarwal, C., Dhanalakshmi, S., Singh, R.P. and Agarwal, R.: Inositol Hexaphosphate Inhibits Growth, and Induces G1 Arrest and Apoptotic Death of Androgen-dependent Human Prostate Carcinoma LNCaP Cells. Neoplasia, 6: 646-659, 2004.

159. Mohan, S., Dhanalakshmi, S., Mallikarjuna, G.U., Singh, R.P. and Agarwal, R.: Silibinin modulates UVB-induced apoptosis via mitochondrial proteins, caspases activation and mitogen-activated protein kinase signaling in human epidermoid carcinoma A431 cells. Biochem. Biophys. Res. Commun., 320: 183-189, 2004.

160. Singh, R.P. and Agarwal, R.: A Cancer Chemopreventive Agent Silibinin, Targets Mitogenic and Survival Signaling in Prostate Cancer. Mutation Res., 555: 21-32, 2004.

161. Mallikarjuna, G.U., Dhanalakshmi, S., Singh, R.P., Agarwal, C. and Agarwal, R.: Silibinin Protects against Photocarcinogenesis via Modulation of Cell Cycle Regulators, and Mitogen-Activated Protein Kinases and Akt Signaling. Cancer Res., 64: 6349-6356, 2004.

162. Singh, R.P., Mallikarjuna, G.U., Sharma, G., Dhanalakshmi, S., Tyagi, A.K., Chan, D.C.F., Agarwal, C. and Agarwal, R.: Oral Silibinin Inhibits Lung Tumor Growth in Athymic Nude Mice and Forms a Novel Chemo-combination with Doxorubicin Targeting NF-B-mediated Inducible Chemoresistance. Clin. Cancer Res., 10: 8641-8647, 2004.

163. Singh, R.P., Dhanalakshmi, S., Agarwal, C. and Agarwal, R.: Silibinin strongly inhibits growth and survival of human endothelial cells via cell cycle arrest and down-regulation of survivin, Akt and NF-B: implications for angioprevention and antiangiogenic therapy. Oncogene, 24: 1188-1202, 2005.

164. Kaur, M., Agarwal, C., Singh, R.P., Guan, X., Dwivedi, C. and Agarwal, R.: Skin cancer chemopreventive agent, -santalol, induces apoptotic death of human epidermoid carcinoma A431 cells via caspases activation together with dissipation of mitochondrial membrane potential and cytochrome c release. Carcinogenesis, 26: 369-380, 2005.

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165. Yim, D., Singh, R.P., Agarwal, C., Lee, S., Chi, H. and Agarwal, R.: A Novel Anticancer Agent, Decursin, Induces G1 Arrest and Apoptosis in Human Prostate Carcinoma DU145 Cells. Cancer Res., 65: 1035-1044, 2005.

166. Singh, R.P., Agrawal, P., Yim, D., Agarwal, C. and Agarwal, R.: Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate. Carcinogenesis, 26: 845-854, 2005.

167. Mallikarjuna, G.U., Dhanalakshmi, S., Singh, R.P. and Agarwal, R.: Dietary Feeding of Silibinin Prevents Early Biomarkers of Ultraviolet B Radiation-induced Carcinogenesis in SKH-1 Hairless Mouse Epidermis. Cancer Epidemiology Biomarkers & Prevention, 14: 1344-1349, 2005.

168. Davis-Searles, P.R., Nakanishi, Y., Kim, N.-C., Graf, T.N., Oberlies, N.H., Wani, M.C., Wall, M.E., Agarwal, R. and Kroll, D.J.: Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on anti-proliferative endpoints in human prostate carcinoma cells. Cancer Res., 65: 4448-4457, 2005.

169. Dhanalakshmi, S., Agarwal, C., Singh, R.P. and Agarwal, R.: Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells. J. Biol. Chem., 280: 20375-20383, 2005.

170. Mallikarjuna, G.U., Dhanalakshmi, S., Mohan, S., Singh, R.P. and Agarwal, R.: Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin. Carcinogenesis Advance Access publication April 14, 2005. Carcinogenesis, 26: 1404-1413, 2005.

171. Singh, R.P. and Agarwal, R.: Mechanisms and preclinical efficacy of silibinin in preventing skin cancer. Eur. J. Cancer, 41: 1969-1979, 2005.

172. Singh, R.P. and Agarwal, R.: Prostate cancer and inositol hexaphosphate: efficacy and mechanisms. Anticancer Res., 25: 2891-2903, 2005.

173. Tyagi, A., Singh, R.P., Agarwal, C., Siriwardana, S., Sclafani, R.A. and Agarwal, R.: Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells. Carcinogenesis, 26:1978-1987, 2005.

174. Varghese, L., Agarwal, C., Tyagi, A., Singh, R.P. and Agarwal, R.: Silibinin efficacy against human hepatocellular carcinoma. Clin. Cancer Res., 11: 8441-8448, 2005.

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175. Deep, G., Singh, R.P., Agarwal, C., Kroll, D.J. and Agarwal, R.: Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin. Oncogene, 25: 1053-1069, 2006.

176. Singh, R.P. and Agarwal, R.: Natural flavonoids targeting deregulated cell cycle progression in cancer cells. Current Drug Targets, 7: 345-354, 2006.

177. Veluri, R., Singh, R.P., Liu, Z., Thompson, J.A., Agarwal, R. and Agarwal, C.: Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Carcinogenesis, Advance Access published online on February 10th, 2006. Carcinogenesis, 27: 1445-1453, 2006.

178. Singh, R. P. and Agarwal, R.: Prostate cancer prevention by silibinin – bench to bedside. Mol. Carcinogenesis, 45: 436-442, 2006.

179. Singh, R.P., Dhanalakshmi, S., Mohan, S., Agarwal, C. and Agarwal, R.: Silibinin inhibits UVB- and EGF-induced mitogenic and cell survival signaling involving AP-1 and NF-κB in mouse epidermal JB6 cells. Mol. Cancer Therapeutics, 5: 1145-1153, 2006.

180. Kaur, M., Agarwal, R. and Agarwal, C.: Grape Seed Extract induces anoikis and caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: possible role of ATM-p53 activation. Mol. Cancer Therapeutics, 5: 1265-1274, 2006.

181. Dwivedi, C., Valluri, H.B., Guan, X. and Agarwal, R.: Chemopreventive effects of α-santalol on UVB-induced skin cancer development. Carcinogenesis, Advance Access published online on May 4th, 2006. Carcinogenesis, 27: 1917-1922, 2006.

182. Singh, R.P., Deep, G., Chittezhath, M., Kaur, M., Dwyer-Nield, L.D., Malkinson, A.M. and Agarwal, R.: Effect of silibinin on the growth and progression of primary lung tumors in mice. J. Natl. Cancer Inst., 98: 845-855, 2006.

183. Tyagi, A., Singh, R. P., Agarwal, C. and Agarwal, R.: Silibinin activates p53-caspase-2 pathway and causes caspase-mediated cleavage of cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: an evidence for a regulatory loop between p53 and caspase-2. Carcinogenesis, Advance Access published online on June 15th, 2006. Carcinogenesis, 27: 2269-2280, 2006.

184. Gu, M., Singh, R.P., Dhanalakshmi, S., Mohan, S. and Agarwal, R.: Differential effect of silibinin on E2F transcription factors and associated biological events in chronically ultraviolet B exposed skin versus tumors in SKH1 hairless mice. Mol. Cancer Therapeutics. 5: 2121-2129, 2006.

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185. Singh, R. P. and Agarwal, R.: Mechanisms of action of novel agents for prostate cancer chemoprevention. Endocrine-Related Cancer, 13: 751-778, 2006.

186. Agarwal, R., Agarwal, C., Ichikawa, H., Singh, R.P. and Aggarwal, B.B.: Anticancer Potential of Silymarin: From Bench to Bedside and Back. Anticancer Res., 26: 4457-4498, 2006.

187. Kaur, M., Singh, R.P., Gu, M., Agarwal, R. and Agarwal, C.: Grape Seed Extract Inhibits in Vitro and in Vivo Growth of Human Colorectal Carcinoma Cells. Clin Cancer Res., 12: 6194-6202, 2006. This publication has had an AACR press release entitled “Grape seed extract halts cell cycle, checking growth of colorectal tumors in mice” dated October 18th, 2006. Also featured on Forbes and Rocky Mountain Newspaper.

188. Agarwal, C., Tyagi, A. and Agarwal, R.: Gallic acid causes inactivating phosphorylation of cdc25A/C-cdc2 via ATM-Chk2 activation, leading to cell cycle arrest, and induces apoptosis in human prostate carcinoma DU145 cells. Mol. Cancer Therapeutics, 5: 3294-3302, 2006.

189. Flaig, T.W., Su, L.-J., Harrison, G., Agarwal, R. and Glodé, L.M.: Silibinin synergizes with mitoxantrone to inhibit cell growth and induce apoptosis in human prostate cancer cells. Int. J. Cancer, 120: 2028-2033, 2007.

190. Flaig, T.W., Gustafson, D.L., Su, L.-J., Zirrolli, J., Crighton, F., Harrison, G., Pierson, A. S., Agarwal, R. and Glodé, L.M.: A Phase I and Pharmacokinetic Study of Silybin-Phytosome in prostate cancer patients. Investigational New Drugs, 25: 139-146, 2007.

191. Kaur, M. and Agarwal, R.: Silymarin and epithelial cancer chemoprevention: how close we are to bedside? Toxicol. Appl. Pharmacol., 224: 350-359, 2007.

192. Kaur, M. and Agarwal, R.: Transcription Factors: Molecular Targets for Prostate Cancer Intervention by Phytochemicals. Current Cancer Drug Targets, 7: 355-367, 2007.

193. Singh, R.P. and Agarwal, R.: Inducible Nitric Oxide Synthase-Vascular Endothelial Growth Factor Axis: A Potential Target to Inhibit Tumor Angiogenesis by Dietary Agents. Current Cancer Drug Targets, 7: 475-483, 2007.

194. Gu, M., Singh, R.P., Dhanalakshmi, S., Agarwal, C. and Agarwal, R.: Silibinin Inhibits Inflammatory and Angiogenic Attributes in Photocarcinogenesis in SKH-1 Hairless Mice. Cancer Res., 67: 3483-3491, 2007.

195. Agarwal, C., Tyagi, A., Kaur, M. and Agarwal, R.: Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells. Carcinogenesis, 28: 1463-1470, 2007.

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196. Agarwal, C., Veluri, R., Kaur, M., Chou, S.-C., Thompson, J.A. and Agarwal, R.: Fractionation of high molecular weight tannins in grape seed extract and identification of procyanidin B2-3,3’-di-O-gallate as a major active constituent causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Carcinogenesis, 28: 1478-1484, 2007.

197. Deep, G., Oberlies, N.H., Kroll, D.J. and Agarwal, R.: Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells. Carcinogenesis, 28: 1533-1542, 2007.

198. Raina, K., Singh, R.P., Agarwal, R. and Agarwal, C.: Oral Grape Seed Extract Inhibits Prostate Tumor Growth and Progression in TRAMP Mice. Cancer Research, 67: 5976-5982, 2007.

199. Deep, G. and Agarwal, R.: Chemopreventive Efficacy of Silymarin in Skin and Prostate Cancer. Integrative Cancer Therapies, 6: 130-145, 2007.

200. Raina, K. and Agarwal, R.: Combinatorial Strategies for Cancer Eradication by Silibinin and Cytotoxic Agents: Efficacy and Mechanisms. Acta Pharmacologica Sinica, 28: 1466-1475, 2007.

201. Velmurugan, B., Agarwal, R. and Singh, R.P.: Role of Bioactive Natural Compounds in Cancer Control. Phytopharmacology and Therapeutic Values III of the Series Recent Progress in Medicinal Plants, Vol. 21, 383-412, 2007.

202. Roy, S., Kaur, M., Agarwal, C., Tecklenburg, M., Sclafani, R.A. and Agarwal, R.: P21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells. Mol. Cancer Therapeutics, 6: 2696-2707, 2007.

203. Tyagi, A., Raina, K., Singh, R.P., Gu, M., Agarwal, C., Harrison, G., Glodé, L.M. and Agarwal, R.: Chemopreventive Effects of Silymarin and Silibinin on N-Butyl-N-(4-hydroxybutyl) Nitrosamine-induced Urinary Bladder Carcinogenesis in Male ICR Mice. Mol. Cancer Therapeutics, 6: 3248-3255, 2007.

204. Raina, K., Blouin, M.J., Singh, R.P., Majeed, N., Deep, G., Varghese, L., Glodé, L.M., Greenberg, N.M., Hwang, D., Cohen, P., Pollak, M.N. and Agarwal, R.: Dietary Feeding of Silibinin Inhibits Prostate Tumor Growth and Progression in Transgenic Adenocarcinoma of the Mouse Prostate Model. Cancer Research, 67: 11083-11091, 2007.

205. Singh, R.P., Deep, G., Blouin, M.J., Pollak, M.N. and Agarwal, R.: Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft. Carcinogenesis, 28: 2567-2574, 2007.

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206. Graf, T.N., Wani, M.C., Agarwal, R., Kroll, D.J. and Oberlies, N.H.: Gram-scale purification of flavonolignan diastereoisomers from Silybum marianum (milk thistle) in support of preclinical in vivo studies for prostate cancer chemoprevention. Planta Medica, Adv. Access Published Online October 18th, 2007.

207. Singh, R.P., Tyagi, A., Sharma, G., Mohan, S. and Agarwal, R.: Oral Silibinin Inhibits In Vivo Human Bladder Tumor Xenograft Growth Involving Down-Regulation of Survivin. Clin. Cancer Res., 14: 300-308, 2008.

208. Anwar, A., Gu, M., Brady, S., Qamar, L., Behbakht, K., Shellman, G.Y., Agarwal, R., Norris, D.A., Horwitz, L.D. and Fujita. M.: Photoprotective Effects of Bucillamine against UV-Induced skin Damage in a SKH-1 Hairless Mouse Model. Photochemistry Photobiology, In Press, 2008.

209. Deep, G., Oberlies, N.H., Kroll, D.J. and Agarwal, R.: Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells. Int. J. Cancer, In Press, 2008.

210. Singh, R.P., Gu, M. and Agarwal, R.: Silibinin Inhibits Colorectal Cancer Growth by Inhibiting Tumor Cell Proliferation and Angiogenesis. Cancer Res., In Press, 2008.

211. Raina, K., Rajamanickam, S., Singh, R.P. and Agarwal, R.: Chemopreventive Efficacy of Inositol Hexaphosphate against Prostate Tumor Growth and Progression in TRAMP Mice. Clin. Cancer Res., In Press, 2008.

212. Raina, K., Rajamanickam, S., Deep, G., Singh, M., Agarwal, R. and Agarwal, C.: Chemopreventive Effects of Oral Gallic Acid Feeding on Tumor Growth and Progression in TRAMP Mice. Mol. Cancer Therapeutics, Accepted pending minor revisions, 2008.

213. Singh, R.P. and Agarwal, R.: Cosmeceutical Benefits of Silibinin. Clinics in Dermatology. In Press, 2008.

214. Kaur, M., Agarwal, R. and Agarwal, C.: Grape Seed Extract – a write up. Cancer Enzyclopedia. In Press, 2008.

215. Tyagi, A., Sharma, Y., Agarwal, C. and Agarwal, R.: Silibinin Impairs Constitutively Active TGF-EGFR Autocrine Loop in Advanced Human Prostate Carcinoma Cells. Pharmaceutical Research, In Press, 2008.

216. Deep, G., Oberlies, N.H., Kroll, D.J. and Agarwal, R.: Isosilybin B causes Androgen Receptor Degradation in Human Prostate Carcinoma LNCaP and 22Rv1 Cells via PI3K-Akt-Mdm2-Mediated Pathway. Oncogene, In Press, 2008.

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217. Ramasamy, K. and Agarwal, R.: Multitargeted therapy of cancer by silymarin. Submitted, 2008.

218. Kaur, M., Deep, G. and Agarwal, R.: Silibinin in skin health: Efficacy and mechanism of action. In Blair, R.M. and Tabor, A. Eds. "Nutritional Cosmetics: Beauty from Within" to be published by William Andrew Publishing, In Press, 2008.

219. Chittezhath, M., Deep, G., Singh, R.P., Agarwal, C. and Agarwal, R.: Silibinin inhibits cytokine-induced STATs, MAPKs, NF-κB and AP-1 activation, and down-regulates HIF-1 and iNOS in human lung epithelial carcinoma A549 cells. Submitted, 2008

220. Singh, R.P., Raina, K., Sharma, G. and Agarwal, R.: Silibinin Alters Angiogenesis and Epithelial-Mesenchymal-Transition to Suppress Prostate Tumor Progression and Metastasis in Mice. Submitted, 2008.

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BOOK CHAPTERS1. Agarwal, R. and Mukhtar, H.: Cutaneous chemical carcinogenesis. In

Pharmacology of the Skin, Mukhtar, H. (ed), CRC Press, pp. 371-387, 1991.

2. Mukhtar, H., Agarwal, R. and Bickers, D.R.: Cutaneous metabolism of xenobiotics and steroid hormones. In Pharmacology of the Skin, Mukhtar, H. (ed), CRC Press, pp. 89-109, 1991.

3. Raza, H., Agarwal, R. and Mukhtar, H.: Cutaneous glutathione S-transferases. In Pharmacology of the Skin, Mukhtar, H. (ed), CRC Press, pp. 131-137, 1991.

4. Athar, M., Agarwal, R., Bickers, D.R. and Mukhtar, H.: Role of reactive oxygen species in skin. In Pharmacology of the Skin, Mukhtar, H. (ed), CRC Press, pp. 269-279, 1991.

5. Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Cancer chemoprevention by green tea polyphenols. Proceedings of the International Symposium on Tea Sciences, Yaminishi, T. and Tomita, I. (eds), pp. 12-16, 1992.

6. Mukhtar, H. and Agarwal, R.: Cytochrome P-450-dependent metabolism of drugs and carcinogens in skin. In Health Risk Assessment: Dermal and Inhalation Exposure and Absorption of Toxicants, Wang, R.G.M., Knaak, J.B. and Maibach, H.I. (eds), CRC Press, pp. 47-61, 1992.

7. Agarwal, R. and Mukhtar, H.: Chemical carcinogenesis in skin: causation, mechanism and role of oncogenes. In Health Risk Assessment: Dermal and Inhalation Exposure and Absorption of Toxicants, Wang, R.G.M., Knaak, J.B. and Maibach, H.I. (eds), CRC Press, pp. 291-305, 1992.

8. Agarwal, R. and Mukhtar, H.: Oxidative stress in skin chemical carcinogenesis. In Oxidative Stress in Dermatology, Fuchs, J. and Packer, L. (eds), Marcel Dekker, Inc., pp. 207-241, 1993.

9. Mukhtar, H., Agarwal, R. and Katiyar, S.K.: Anticarcinogenic and antiinflammatory effects of green tea in murine skin, Proceedings of the 2nd International Symposium on Green Tea, Seoul, Korea, pp. 33-55, 1993.

10. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Introduction: Sources, occurrence, nomenclature and carcinogenicity of polycyclic aromatic hydrocarbons. In Handbook of Chromatography: Liquid chromatography of polycyclic aromatic hydrocarbons, Rathore, H.S. (ed), CRC Press, pp. 1-17, 1993.

11. Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Cancer chemoprevention by green tea components. In Advances in Experimental Medicine and Biology: Diet and Cancer:

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Markers, Prevention and Treatment, Jacobs, M.M. (ed), Plenum Press, Volume 354, pp. 121-132, 1993.

12. Mukhtar, H., Mercurio, M.G. and Agarwal, R.: Murine skin carcinogenesis: Relevance to humans. In Skin Cancer: Mechanism and Human Relevance, Mukhtar, H. (ed), CRC Press, pp. 3-8, 1994.

13. Agarwal, R., Khan, S.G. and Mukhtar, H.: Ras p21 post-translational processing: An overview and studies in skin cancer. In Skin Cancer: Mechanism and Human Relevance, Mukhtar, H. (ed), CRC Press, pp. 293-304, 1994.

14. Agarwal, R., Katiyar, S.K. and Mukhtar, H.: Skin cancer chemoprevention by naturally occurring polyphenols. In Skin Cancer: Mechanism and Human Relevance, Mukhtar, H. (ed), CRC Press, pp. 391-399, 1994.

15. Agarwal, R. and Mukhtar, H.: Cancer chemoprevention by polyphenols in green tea and artichoke. In Advances in Experimental Medicine and Biology: Dietary Phytochemicals in Cancer Prevention and Treatment, Plenum Press, Volume 401, pp. 35-50, 1996.

16. Lahiri, M., Mukhtar, H. and Agarwal, R.: Reactive intermediates and skin cancer. In Carcinogenicity: Testing, Predicting, and Interpreting Chemical Effects. Kitchin, K.T. (Ed), Marcel Dekker, Inc., 679-714, 1999.

17. Singh, R.P. and Agarwal, R.: SENCAR mouse skin tumorigenesis model. In Tumor Models in Cancer Research. Teicher, B.A. (Ed), The Humana Press Inc, Totowa, NJ, 2001, pp. 359-380.

CONFERENCES/SEMINARS/SYMPOSIUMS1. Agarwal, R., Satsangi, R.K., Shukla, M.K., and Chaudhary, C.: Synthesis and CNS

activity of 4-aryl-1-(p-(3’,4’,5’-tri-substituted benzamido)-benzoyl)-piperazines. Paper presented at XIII Annual Meeting of Indian Pharmacological Society (India) September 1980.

2. Agarwal, R., Satsangi, R.K., and Shukla, M.K.: Synthesis and CNS activity of 3-(4-(1’-piperazinamido-4- aryl(methyl)- anilinomethyl)- benzoxazolin- 2-ones/ thiones. Paper presented at Convention of Chemists (India), December, 1980.

3. Agarwal, R.: Chemistry and CNS activity of 1-(4-methyl coumarin-7yl)-oxyacetyl-3-methyl-4-(substituted phenyl) hydrazono/azo-pyrazolin-5-ones. Paper presented at Convention of Chemists (India), December, 1981.

4. Chaudhary, C., Agarwal, R., and Misra, V.S.: Synthesis of 1-(4-morpholino-phenyl)-2-aryl-4-(3,4-disubstituted benzylidene)-imidazolin-5-ones as CNS active agents. Paper presented at Convention of Chemists (India), December, 1981.

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5. Singh, C., Agarwal, R., and Misra, V.S.: Synthesis of 1-(p-substituted phenyl)-2-oxo-3(o-chlorophenoxy)-4-(2-arylindol-3yl)-azetidines. Paper presented at Convention of Chemists (India), December, 1981.

6. Agarwal, R., Kumar, S., and Mehrotra, N.K.: Fractionation of Jute Batching Oil for identifying tumour inducing components. Paper presented at IIIrd Annual Convention of Indian Association for Cancer Research, March, 1984.

7. Agarwal, R., Gupta, K.P., Kumar, S., and Mehrotra, N.K.: Ability of fresh and used industrial crude oil to induce AHH in mo:use epidermis. Paper presented at IVth Annual Conference of Society of Toxicology (India), November, 1984.

8. Mohan, R.R., Agarwal, R., and Misra, V.S.: Synthesis of some newer quinazolines as pharmacologically active agents. Paper presented at 72nd session of Indian Science Congress Association, January, 1985.

9. Mohan, R.R., Agarwal, C., Agarwal, R., and Misra, V.S.: Indophenazines: A new class of CNS and anti-inflammatory agents. Paper presented at National Symposium of Newer Trends in Synthetic Heterocyclic Chemistry, February, 1985.

10. Agarwal, R., Kumar, S., Shukla, Y., and Mehrotra, N.K.: A study of tumour initiating potential of JBO fractions in mouse skin. Paper presented at IVth Annual Convention of Indian Association for Cancer Research, February, 1985.

11. Agarwal, R., Shukla, Y., Kumar, S., and Mehrotra, N.K.: Carcinogenic effect of JBO-P and its fractions over mouse skin. Paper presented at Vth Annual Conference of Society of Toxicology (India), November, 1985.

12. Agarwal, R., Kumar, S., Antony, M., and Mehrotra, N.K.: Chemical and biochemical basis of tumour promoting ability of JBO. Paper presented at Vth Annual Conference of Society of Toxicology (India), November, 1985.

13. Agarwal, R., Bhargava, S.K., Kidwai, M.M., Mehrotra, N.K., and Lal, M.M.: Estimation of BaP in ambient air of different areas of Lucknow city. Paper presented at National Symposium of chemical carcinogenesis and carcinogens in the environment. December, 1985.

14. Agarwal, R., and Kumar, S.: Protein quality of some vigna unguiculata samples growing in Manipur. Paper presented at Annual Conference of India Council of Chemists, December, 1987.

15. Agarwal, R., Shukla, Y., Kumar, S., and Mehrotra, N.K.: Tumour initiating potential of JBO-P and its fractions over mouse skin. Paper presented at Vllth Annual Convention of Indian Association for Cancer Research, February, 1988.

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16. Agarwal, R., and Burke, M.: Nucleotide and temperature-induced changes in the flexibility between SH1 (cys-707) and cys-522 in myosin subfragment 1 probed by crosslinking. FASEB J., 4, A1214, 1990.

17. Agarwal, R., Raza, H., and Mukhtar, H.: Lipoxygenase catalyzed metabolism of the skin carcinogen BaP in rodent and human epidermis. J. Invest. Dermatol., 94, 502, 1990.

18. Mukhtar, H., Athar, M., Agarwal, R., Elmets, C.A., and Bickers, D.R.: Chloroaluminum phthalocyanine tetrasulfonate (ALPCTS) photodynamic therapy (PDT) of cutaneous tumors. Photochem. Photobiol., 51 (Suppl), 74S, 1990.

19.Agarwal, R. and Mukhtar, H.: Lipoxygenase catalyzed metabolism of benzo(a)pyrene and benzo(a)pyrene-7,8-diol in human skin. Toxicologist, 11, 346, 1991.

20. Mukhtar, H., Agarwal, R., Raza, H. and Bickers, D.R.: Glutathione S-transferase-dependent conjugation of leukotriene A4 to leukotriene C4 in rodent and human skin. FASEB J., 5, A1205, 1991.

21. Agarwal, R., Tafel, J. and Mukhtar, H.: Role of singlet oxygen in in vivo and in vitro photodestruction of microsomal membranes by chloroaluminum phthalocyanine tetrasulfonate. FASEB J., 5, A1563, 1991.

22. Zaidi, S.I.A., Agarwal, R., Rihter, B.D., Kenney, M.E., Oleinick, N.L. and Mukhtar, H.: Photoenhancement of lipid peroxidation in human erythrocyte membranes by new silicon phthalocyanines. FASEB J., 5, A1563, 1991.

23. Agarwal, R., Elmets, C.A., Bickers, D.R. and Mukhtar, H.: Photodynamic therapy of ultraviolet B radiation-induced murine skin tumors by photofrin-II and chloroaluminum phthalocyanine tetrasulfonate. J. Invest. Dermatol., 96, 589 1991.

24. Zaidi, S.I.A., Evans, B.N., Raza, H., Agarwal, R., Ahmad, H., Awasthi, Y.C. and Mukhtar, H.: Altered expression of glutathione S-transferase isozymes in murine and human skin tumors. J. Invest. Dermatol., 96, 599, 1991.

25. Mukhtar, H., Agarwal, R., Wang, Z.Y. and Bickers, D.R.: Antimutagenic and anti-tumorigenic activities of nordihydroguaiaretic acid. Proc. Amer. Assoc. Cancer Res., 32, 147, 1991.

26. Agarwal, R. and Mukhtar, H.: Metabolism of benzo(a)pyrene and benzo(a)pyrene 7,8-dihydrodiol catalyzed by human rodent epidermal lipoxygenase. Proc. Amer. Assoc. Cancer Res., 32, 117, 1991.

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27. Mukhtar, H., Zaidi, S.I.A., Agarwal, R., Eichler, G., Rihter, B., Kenney, M.E., Clay, M.D., Oleinick, N.L. and Bickers, D.R.: Photodynamic effects of silicon phthalocyanine in Chinese hamster V79 cells and human erythrocyte membranes. Photochem. Photobiol., 53, 93S, 1991.

28. Burke, M. and Agarwal, R.: Substructure of myosin subfragment 1 by photocross-linking. Location of the cross-link formed in the presence of MgADP from SH1 to the 50-kDa domain. Proc. 15th Int. Congress of Biochem., Jerusalem, Israel, August, 1991, p 163.

29. Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Protection against skin tumor promotion in SENCAR mice by green tea polyphenols. 2nd Annual Meeting Am. Inst. Cancer Res., Washington, DC, October, 1991.

30. Agarwal, R., Jugert, F.K., Merk, H.F., Bickers, D.R. and Mukhtar, H.: Multiple cytochrome P-450 isozymes in murine skin: induction by pyridine. FASEB J., 6, A1567, 1992.

31. Jugert, F.K., Agarwal, R., Merk, H.F., Bickers, D.R. and Mukhtar, H.: Induction of multiple cytochrome P-450 isoenzymes in murine skin by dexamethasone. FASEB J., 6, A1567, 1992.

32. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of tumor promoter-caused induction of epidermal ornithine decarboxylase (ODC) and skin tumor promotion in SENCAR mice by green tea polyphenols. FASEB J., 6, A1495, 1992.

33. Agarwal, R., Katiyar, S.K., Zaidi, S.I.A. and Mukhtar, H.: Inhibition of tumor promoter-caused epidermal ornithine decarboxylase induction by polyphenolic fraction isolated from green tea. Proc. Amer. Assoc. Cancer Res., 33:168, 1992.

34. Katiyar, S.K., Agarwal, R., Wang, Z.Y. and Mukhtar, H.: Protection against 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in SENCAR mice by polyphenolic fraction from green tea. Proc. Amer. Assoc. Cancer Res., 33:168, 1992.

35. Zaidi, S.I.A., Agarwal, R. and Mukhtar, H.: Expression of glutathione S-transferases in murine and human skin tumors. Proc. Amer. Assoc. Cancer Res., 33:11, 1992.

36. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of tumor promotion in murine skin by green tea polyphenols. J. Invest. Derm., 98, 663, 1992.

37. Jugert, F.K., Agarwal, R., Merk, H.F., Bickers, D.R. and Mukhtar, H.: Evidence for the occurrence of multiple cytochrome P-450 isozymes in murine skin: induction by dexamethasone. J. Invest. Derm., 98, 652, 1992.

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38. Zaidi, S.I.A., Agarwal, R., Bickers, D.R. and Mukhtar, H.: Mechanism of photodynamic effects of chloroaluminum phthalocyanine. J. Invest. Derm., 98, 657, 1992.

39. Agarwal, R., Jugert, F.K., Merk, H.F., Bickers, D.R. and Mukhtar, H.: Induction of cytochrome P-450 isozymes 1A, 2B and 3A in murine skin by pyridine. J. Invest. Derm., 98, 652, 1992.

40. Agarwal, R., Raza, H., Bickers, D.R. and Mukhtar, H.: Biotransformation of leukotriene A4 to leukotriene C4 by affinity purified glutathione s-transferase from rat skin. Skin Pharmacol., 5, 193, 1992.

41. Jugert, F.K., Agarwal, R., Frankenberg, S., Junginger, H., Bickers, D.R., Mukhtar, H. and Merk, H.F.: Multiple inducible cytochrome p450 isozymes in human epidermal keratinocytes. Skin Pharmacol., 5, 197, 1992.

42. Jugert, F.K., Agarwal, R., Bickers, D.R., Merk, H.F. and Mukhtar, H.: Induction of cytochrome P450 subfamilies 1A, 2B, 2E and 3A in murine skin by dexamethasone. Skin Pharmacol., 5, 198, 1992.

43. Katiyar, S.K., Agarwal, R., Wood, G.S. and Mukhtar, H.: Skin cancer chemoprevention by green tea polyphenols. Skin Pharmacol., 5, 198, 1992.

44. Studer, J.A., Jugert, F.K., Fleming, T.E., Elmets, C.A., Bik, D.P., Agarwal, R. and Mukhtar, H.: Cytochrome P4501A1-dependent metabolism of skin carcinogen benzo(a)pyrene in human langerhans cells. Skin Pharmacol., 5, 205, 1992.

45. Zaidi, S.I.A., Agarwal, R., Bickers, D.R. and Mukhtar, H.: Photodynamic therapy of murine skin tumors. Skin Pharmacol., 5, 207, 1992.

46. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of skin tumor promotion by green tea polyphenols: mechanistic studies. Environmental Skin Cancer: Mechanisms, Models and Human Relevance, 1992.

47. Khan, S.G., Bickers, D.R., Mukhtar, H. and Agarwal, R.: Farnesyltransferase activity and Ha-ras p21 processing during skin tumorigenesis. Environmental Skin Cancer: Mechanisms, Models and Human Relevance, 1992.

48. Zaidi, S.I.A., Agarwal, R., Bickers, D.R. and Mukhtar, H.: First and second generation photosensitizer-based photodynamic therapy of murine skin tumors. Environmental Skin Cancer: Mechanisms, Models and Human Relevance, 1992.

49. Jugert, F.K., Agarwal, R., Mukhtar, H. and Merk, H.F.: Induction of cytochrome P450 subfamilies 1A, 2B, 2E and 3A in murine skin by dexamethasone. 13 th European Workshop on Drug Metabolism, European Soc. Biochem. Pharmacol., 1992.

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50. Studer, J.A., Agarwal, R., Jugert, F.K., Fleming, T.E., Mukhtar, H. and Elmets, C.A.: Cytochrome P4501A1-dependent metabolism of the skin carcinogen benzo(a)pyrene in human langerhans cells. Central Regional Meeting, Soc. Invest. Dermatol., 1992.

51. Agarwal, R., Khan, S.G., Bickers, D.R. and Mukhtar, H.: Processing of overexpressed Ha-ras oncoprotein p21 in chemical carcinogen-induced tumors in SENCAR mouse skin. J. Invest. Dermatol., 100:601, 1993.

52. Katiyar, S.K., Agarwal, R., Bickers, D.R. and Mukhtar, H.: Chemopreventive effects of green tea against stage I and stage II tumor promotion and malignant conversion in SENCAR mouse skin. J. Invest. Dermatol., 100:603, 1993.

53. Mukhtar, H., Katiyar, S.K., Agarwal, R. and Bickers, D.R.: Inhibition of ultraviolet B radiation-induced inflammatory responses in SKH-1 hairless mice by a polyphenolic fraction isolated from green tea. J. Invest. Dermatol., 100:600, 1993.

54. Khan, S.G., Bickers, D.R., Mukhtar, H. and Agarwal, R.: Farnesylation of Ha-ras p21 in ultraviolet B radiation-induced tumors in SKH-1 hairless mice. J. Invest. Dermatol., 100:599, 1993.

55. Agarwal, R., Khan, S.G. and Mukhtar, H.: Ha-ras processing during cutaneous chemical carcinogenesis. Proc. Am. Assoc. Cancer Res., 34:526, 1993.

56. Khan, S.G., Mukhtar, H. and Agarwal, R.: Farnesyltransferase activity in ultraviolet B (UVB)-induced skin tumors in SKH-1 hairless mice. Proc. Am. Assoc. Cancer Res., 34:526, 1993.

57. Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Protection against diethylnitrosamine (DEN) and benzo()pyrene (BP)-induced forestomach and lung tumorigenesis in A/J mice by green tea. Proc. Am. Assoc. Cancer Res., 34:555, 1993.

58. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Protection against malignant conversion of mouse skin papillomas to carcinomas by green tea polyphenols. Proc. Am. Assoc. Cancer Res., 34:555, 1993.

59. Agarwal, R., Katiyar, S.K., Khan, S.G. and Mukhtar, H.: Inhibition of ultraviolet B radiation (UVB)-induced changes in the skin of SKH-1 hairless mice by green tea polyphenols. Photochem. Photobiol., 57:24S, 1993.

60. Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Protection against tumor promoter-induced inflammation in murine skin by green tea polyphenols. 2nd Tricontinental Meeting of JSID, SID and ESDR, Japan, 1992. J. Invest. Dermatol., 101:393, 1993.

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61. Agarwal, R., Khan, S.G. and Mukhtar, H.: Ras p21 farnesylation in ultraviolet radiation-induced tumors in murine skin. 2nd Tricontinental Meeting of JSID, SID and ESDR, Japan, 1992. J. Invest. Dermatol., 101:394, 1993.

62. Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Protective effects of green tea against 12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B radiation-induced inflammation in murine skin. Skin Pharmacol., Abstracts:11, 1993.

63. Agarwal, R., Khan, S.G. and Mukhtar, H.: Ras protein p21 processing in ultraviolet B radiation-induced tumorigenesis in the skin of SKH-1 hairless mice. Skin Pharmacol., Abstracts:1, 1993.

64. Khan, S.G., Saxena, R., Mukhtar, H. and Agarwal, R.: ras p21 processing modulates protein kinase C (PKC) isozymes and ornithine decarboxylase (ODC) transcripts: possible role in tumor growth. Proc. Am. Assoc. Cancer Res., 35:616, 1994.

65. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Protection against diethylnitrosamine (DEN)- and benzo(a)pyrene (BP)-induced forestomach and pulmonary neoplasia in A/J mice by limited oral intubation of green tea polyphenols. Proc. Am. Assoc. Cancer Res., 35:626, 1994.

66. Agarwal, R., Katiyar, S.K., Lundgren, D.W. and Mukhtar, H.: Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity and mRNA in SENCAR mice by silymarin. Proc. Am. Assoc. Cancer Res., 35:626, 1994.

67. Khan, S.G., Saxena, R., Bickers, D.R., Mukhtar, H. and Agarwal, R.: Ras p21 post-translational processing with membrane localization modulates expression and activation of protein kinase c isozyme , II and : Evidence for a role in tumor growth. J. Invest. Dermatol., 102:548, 1994.

68. Jugert, F.K., Agarwal, R., Mukhtar, H., Bickers, D.R. and Merk, H.F.: Dexamethasone and cyclosporin A inducible cytochrome P450 3A in murine and human skin. J. Invest. Dermatol., 102:647, 1994.

69. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of lipid peroxidation in mouse epidermal microsomes by epicatechin derivatives from green tea. J. Invest. Dermatol., 102:652, 1994.

70. Agarwal, R., Katiyar, S.K. and Mukhtar, H.: Inhibitory effect of silymarin, an anti-hepatotoxic flavonoid, on tumor promoter-induced epidermal ornithine decarboxylase activity and mRNA in SENCAR mice. J. Invest. Dermatol., 102:653, 1994.

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71. Dummer, R., Siddiqui, J., Khan, S.G., Haffner, A.C., Rupp, C., Bickers, D.R., Agarwal, R. and Mukhtar, H.: Human basal cell carcinomas frequently express the gene for farnesyltransferase beta subunit. J. Invest. Dermatol., 102:653, 1994.

72. Dummer, R., Siddiqui, J., Khan, S.G., Haffner, A.C., Rupp, C., Bickers, D.R.,

Agarwal, R. and Mukhtar, H.: Increased farnesylprotein transferase activity in human basal cell carcinomas is associated with beta FTase subunit expression. J. Invest. Dermatol., 103:411, 1994.

73. Mukhtar, H., Agarwal, R. and Katiyar, S.K.: Inhibition of mouse skin tumor promotion by ethanol extract of ginger root. Proc. Am. Assoc. Cancer Res., 36:594, 1995.

74. Katiyar, S.K., Agarwal, R., Korman, N.J., Rupp, C.O. and Mukhtar, H.: Inhibition of tumor promoter-caused induction of interleukin-1 (IL-1)-alpha, tumor necrosis factor (TNF)-alpha, and ornithine decarboxylase (ODC) gene expression in SENCAR mouse skin by tea polyphenols. Proc. Am. Assoc. Cancer Res., 36:594, 1995.

75. Agarwal, R., Katiyar, S.K. and Mukhtar, H.: Protection against tumor promotion in mouse skin by silymarin. Proc. Am. Assoc. Cancer Res., 36:593, 1995.

76. Mohan, R.R., Khan, S.G., Agarwal, R. and Mukhtar, H.: Testosterone induces ornithine decarboxylase (ODC) activity and mRNA expression in human prostate carcinoma cell line LNCaP: inhibition by green tea. Proc. Am. Assoc. Cancer Res., 36:274, 1995.

77. Khan, S.G., Dummer, R., Siddiqui, J., Agarwal, R. and Mukhtar, H.: Farnesyltransferase (FTase) activity and gene expression of its and subunits in human skin basal cell carcinomas (BCCs). Proc. Am. Assoc. Cancer Res., 36:527, 1995.

78. Mukhtar, H., Agarwal, R., Korman, N.J., Rupp, C.O. and Katiyar, S.K.: Inhibition of tumor promoter-caused induction of epidermal interleukin-1-alpha, tumor necrosis factor-alpha, and ornithine decarboxylase mRNA expression in SENCAR mouse by green tea polyphenols. J. Invest. Dermatol., 104:575, 1995.

79. Katiyar, S.K., Elmets, C.A., Agarwal, R. and Mukhtar, H.: Protection against ultraviolet B radiation-induced local and systemic suppression of contact hypersensitivity in mice by green tea polyphenols. J. Invest. Dermatol., 104:690, 1995.

80. Agarwal, R., Katiyar, S.K. and Mukhtar, H.: Protective effects of silymarin against ultraviolet B radiation-induced tumorigenesis in SKH-1 hairless mouse skin. J. Invest. Dermatol., 104:635, 1995.

51


81. Mohan, R.R., Katiyar, S.K., Mukhtar, H. and Agarwal, R.: Protective effects of retinoic acid against tumor promotion and progression in low- and high-risk protocols of mouse skin carcinogenesis. J. Invest. Dermatol., 104:574, 1995.

82. Agarwal, R., Katiyar, S.K. and Mukhtar, H.: Protection against photocarcinogenesis in SKH-1 hairless mice by silymarin. Photochem. Photobiol., 61s:14s, 1995.

83. Mukhtar, H., Korman, N.J., Mohan, R.R., Jawed, S., Zaim, M.T. and Agarwal, R.: Phthalocyanine-photodynamic therapy of murine skin tumors: Apoptosis is an early event during tumor shrinkage. Photochem. Photobiol., 61s:41s, 1995.

84. Katiyar, S.K., Elmets, C.A., Agarwal, R. and Mukhtar, H.: Polyphenols from green tea inhibit UVB-caused immune suppression and IL-1 mRNA expression in C3H/HeN mouse skin. Presented at Photocarcinogenesis: Mechanisms, Models and Human Health Implications, October 1995, Washington, D.C. Photodermatol. Photoimmunol. Photomed., 11:234, 1995.

85. Agarwal, R., Katiyar, S.K. and Mukhtar, H.: Protection against photocarcinogenesis by silymarin. Presented at Photocarcinogenesis: Mechanisms, Models and Human Health Implications, October 1995, Washington, D.C. Photodermatol. Photoimmunol. Photomed., 11:233, 1995.

86. Mohan, R.R., Khan, S.G., Katiyar, S.K., Wood, G.S., Bickers, D.R., Mukhtar, H. and Agarwal, R.: Ras oncogene mutations are rare event in ultraviolet B radiation-induced tumorigenesis in mouse skin. Presented at Photocarcinogenesis: Mechanisms, Models and Human Health Implications, October 1995, Washington, D.C. Photodermatol. Photoimmunol. Photomed., 11:230, 1995.

87. Lahiri, M., Agarwal, R. and Mukhtar, H.: 32P postlabelling detection of photoproducts in the epidermis of SKH-1 hairless mice exposed to ultraviolet B radiation. Presented at Photocarcinogenesis: Mechanisms, Models and Human Health Implications, October 1995, Washington, D.C. Photodermatol. Photoimmunol. Photomed., 11:226, 1995.

88. Agarwal, R., Lahiri, M., Mohan, R.R. and Mukhtar, H.: Stage specific anti-tumor promoting potential of silymarin in mouse skin. Proc. Am. Assoc. Cancer Res., 37:278, 1996.

89. Mukhtar, H., Mohan, R.R., Bostwick, D.G., Amini, S.G. and Agarwal, R.: Significantly higher ornithine decarboxylase (ODC) activity in human prostate cancer than in normal tissue. Proc. Am. Assoc. Cancer Res., 37:244, 1996.

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90. Singh, S.V., Mohan, R.R., Agarwal, R., Benson, P.J., Rudy, M.A., Hu, X., Xia, H., Mack, L.M., Mukhtar, H., Gupta, V., Katoh, A. and Zaren, H.A.: Inhibition of H-ras oncogene transformed tumor cell growth in vivo by diallyl disulfide is associated with inhibition of HMG-Co A reductase activity and ras p21 membrane localization. Proc. Am. Assoc. Cancer Res., 37:391, 1996.

91. Agarwal, R., Lahiri, M., Mohan, R.R. and Mukhtar, H.: Anti-tumor promoting potential of silymarin against both phorbol and nonphorbol ester type tumor promoter-caused promotion in SENCAR mouse skin. J. Invest. Dermatol., 106:856, 1996.

92. Lahiri, M., Agarwal, R. and Mukhtar, H.: 32P postlabelling assay: a sensitive tool for detection of ultraviolet B radiation-induced DNA lesions. J. Invest. Dermatol., 106:857, 1996.

93. Katiyar, S.K., Mukhtar, H. and Agarwal, R.: Exceptionally high preventive activity of silymarin against photocarcinogenesis in mouse skin. Experimental Skin Carcinogenesis Conference, Smithville, TX, October, 1996.

94. Lahiri, M., Agarwal, R. and Mukhtar, H.: Beta-naphthoflavone and 22,3,7,8-tetrachlorobenzo-p-dioxin inducible cytochrome P450 1B1 in mouse epidermis. Soc. Toxicol., 1997.

95. Agarwal, R., Mohan, R.R., Khan, S.G. and Mukhtar, H.: Bifonazole, an anti-fungal imidazole, inhibits HMG-CoA reductase followed by ras p21 farnesylation leading to a selective growth inhibition of ras transformed cells. Proc. Am. Assoc. Cancer Res., 38:96, 1997.

96. Zi, X., Feyes, D.K., Mukhtar, H. and Agarwal, R.: Anti-carcinogenic effect of a polyphenolic antioxidant silymarin in breast cancer cells MDA-MB468: a p53-independent induction of WAF1/Cip1/p21 and G1 arrest. Proc. Am. Assoc. Cancer Res., 38:217, 1997.

97. Gali, H., Ahmad, N., Jawed, S., Mukhtar, H. and Agarwal, R.: Inhibition of epidermal growth factor receptor (EGFr) tyrosine kinase activity by silymarin, a polyphenolic antioxidant and potent cancer chemopreventive agent. Proc. Am. Assoc. Cancer Res., 38:263, 1997.

98. Ahmad, N., Feyes, D.K., Agarwal, R. and Mukhtar, H.: P53-independent induction of WAF1/Cip1/p21 regulates the cell cycle mediated apoptosis during photodynamic therapy in human epidermoid carcinoma cells A431. Proc. Am. Assoc. Cancer Res., 38:377, 1997.

99. Mukhtar, H., Ahmad, N., Feyes, D.K. and Agarwal, R.: Green tea polyphenols induce apoptosis and alter the progression of cell cycle in human epidermoid carcinoma cells A431. Proc. Am. Assoc. Cancer Res., 38:580, 1997.

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100. Agarwal, R., Ahmad, N., Javed, S. and Mukhtar, H.: Silymarin, a polyphenolic antioxidant, exerts its anti-tumor promoting effect by inhibiting epidermal growth factor receptor tyrosine kinase activity. J. Invest. Dermatol., 108:547, 1997.

101. Zi, X., Steele, J.D., Mukhtar, H. and Agarwal, R.: Complete preventive effect of silymarin against okadaic acid-caused tumor promotion in mouse skin. J. Invest. Dermatol., 108:600, 1997.

102. Mukhtar, H., Ahmad, N., Feyes, D.K. and Agarwal, R.: Cell cycle arrest and induction of apoptosis in human epidermoid carcinoma cells A431 by green tea polyphenols. J. Invest. Dermatol., 108:600, 1997.

103. Ahmad, N., Feyes, D.K., Agarwal, R. and Mukhtar, H.: Photodynamic therapy results in WAF1/CIP1/P21-mediated cell cycle arrest in G1-phase followed by apoptosis in human squamous carcinoma cells (A431). J. Invest. Dermatol., 108:667, 1997.

104. Ahmad, N., Feyes, D.K., Agarwal, R. and Mukhtar, H.: WAF1/CIP1/P21 mediates G1 arrest in cell cycle and apoptosis by photodynamic therapy (PDT). Photochem. Photobiol., 65s:58s, 1997.

105. Zi, X. and Agarwal, R.: Anti-proliferative and apoptotic effects of a potent cancer preventive agent silymarin are mediated via distinct signals involving respectively ERK and JNK pathways. Proc. Am. Assoc. Cancer Res., 39:291, 1998.

106. Agarwal, R. and Zi, X.: Silymarin decreases prostate specific antigen (PSA) expression concomitant with inhibition of cell growth, induction of neuroendocrine differentiation and perturbations in cell cycle in human prostate carcinoma cells LNCaP. Proc. Am. Assoc. Cancer Res., 39:320, 1998.

107. Ahmad, N., Agarwal, R. and Mukhtar, H.: Involvement of pRb/p105 and E2F during photodynamic therapy mediated G0/G1-phase arrest of human epidermoid carcinoma cells A431. Proc. Am. Assoc. Cancer Res., 39:378, 1998.

108. Agarwal, R.: Skin cancer chemoprevention by a flavonoid antioxidant silymarin. Experimental Skin Carcinogenesis: Third International Meeting, Bastrop, TX, November, 1998.

109. Agarwal, R.: Prostate Cancer Prevention by an antioxidant silymarin. International Conference on Diet and Prevention of Cancer, Tampere, Finland, June, 1999.

110. Zhao, J., Wang, Z.Y and Agarwal, R.: Biodistribution and sulfate- and glucuronidate-conjugate formation of a skin cancer chemopreventive agent silymarin in mice. Proc. Am. Assoc. Cancer Res., 40:258, 1999.

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111. Bhatia, N., Zi, X. and Agarwal, R.: Enhanced polyphenolic nature of flavonoid antioxidants plays detrimental role in the activation of survival factor Akt and apoptosis in prostate cancer DU145 cells: a comparison of silymarin, genistein and EGCG. Proc. Am. Assoc. Cancer Res., 40:533, 1999.

112. Chen, L, Zi, X. and Agarwal, R.: Differential impairment of signaling pathways by skin cancer chemopreventive agents silymarin, quercetin and EGCG: a structure activity response. Proc. Am. Assoc. Cancer Res., 40:533-534, 1999.

113. Zi, X. and Agarwal, R.: Ligand-induced receptor tyrosine kinase endocytosis in prostate cancer cells. Proc. Am. Assoc. Cancer Res., 40:614, 1999.

114. Jiang, W., Zhu, Z., Bhatia, N., Agarwal, R. and Thompson, H.J.: Corticosterone treatment of mouse mammary hyperplasia cells TM10 selectively induces G1 arrest via induction of CDKIs and decrease in both CDKs and cyclin D1. Proc. Am. Assoc. Cancer Res., 40:617, 1999.

115. Zi, X. and Agarwal, R.: Impairment of erbB1-mediated endocytosis signaling by phytic acid: a novel strategy for the secondary prevention of prostate cancer. Proc. Am. Assoc. Cancer Res., 40:654, 1999.

116. Agarwal, R.: Cell signaling, regulators of cell cycle and apoptosis as molecular targets for prostate cancer intervention by dietary agents. Proc. Signal Transduction Pathways and Regulation of Gene Expression as Therapeutic Targets, Luxembourg, January, 2000.

117. Jiang, C., Agarwal, R. and Lu, J.: Silymarin, a flavonoid phytochemical, inhibts key angiogenic attributes of vascular endothelial cells. Proc. Am. Assoc. Cancer Res., 41:847, 2000.

118. Agarwal, C., Zhao, J. and Agarwal, R.: Grape seed polyphenols inhibit breast carcinoma MDA-MB468 cell growth by inhibiting MAPKs, and inducing G1 arrest and differentiation. Proc. Am. Assoc. Cancer Res., 41:532-533, 2000.

119. Bhatia, N. and Agarwal, R.: Hydrogen peroxide-mediated pro-oxidant activity of epigallocatechin-3 gallate in human prostate carcinoma DU145 cells: effect on cell growth and viability, and MAP kinases. Proc. Am. Assoc. Cancer Res., 41:533, 2000.

120. Bhatia, N., Sharma, Y., Zhao, J. and Agarwal, R.: Therapeutic efficacy of a cancer preventive agent, silymarin: involvement of anti-proliferative and cell deletion effects via inhibition of mitogenic signaling. Proc. Am. Assoc. Cancer Res., 41:663, 2000.

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121. Sharma, Y. and Agarwal, R.: A flavonoid antioxidant silibinin inhibits TGF expression and its bining to erbB1 resulting in impairment of ligand/receptor autocrine loop in human prostate carcinoma cells. Proc. Am. Assoc. Cancer Res., 41:846, 2000.

122. Zhao, J., Slaga, T.J. and Agarwal, R.: Inhibition of phorbol ester-caused oxidative stress and inflammatory responses by a polyphenolic fraction from coffee. Proc. Am. Assoc. Cancer Res., 41:846, 2000.

After Joining DOPS, SOP, UCHSC123. Singh, R.P., Agarwal, C. and Agarwal, R.: Novel anti-carcinogenic function of

inositol hexaphosphate in human prostate carcinoma DU145 cells: modulation of cell-cycle regulators, growth inhibition, and induction of G1 arrest. Proc. Am. Assoc. Cancer Res., 42:461, 2001.

124. Tyagi, A., Agarwal, C. and Agarwal, R.: Silibinin induces growth inhibition and G1 arrest via induction of CDKIs and decrease in CDKs leading to hypophosphorylation of Rb/p107 in prostate carcinoma DU145 cells. Proc. Am. Assoc. Cancer Res., 42:462, 2001.

125. Agarwal, C., Singh, R.P., Tyagi, A.K. and Agarwal, R.: Anti-carcinogenic effect of grape seed extract against prostate cancer. Proc. Am. Assoc. Cancer Res., 42:462, 2001.

126. Tyagi, A., Agarwal, C., Chan, D.C. and Agarwal, R.: Strong synergistic efficacy of silibinin and doxorubicin combination against human prostate carcinoma DU145 cells. Proc. Am. Assoc. Cancer Res., 42:462, 2001.

127. Agarwal, R.: Silymarin and prostate cancer: epigenetic events as molecular targets. 1st Int. Conf. on Mechanisms of Action of Nutraceuticals, October, 2001.

128. Agarwal, C., Dhanalakshmi, S. and Agarwal, R.: Anti-proliferative and apoptotic effects of sililbinin in human colon cancer HT29 cells: Alterations in cell cycle progression via CDKI induction concomitant with a decrease in kinase activity of CDKs and associated cyclins. Proc. Am. Assoc. Cancer Res., 43:125, 2002.

129. Singh, R.P., Dhanalakshmi, S., Tyagi, A.K., Chan, D.C.F., Agarwal, C. and Agarwal R.: Dietary feeding of silibinin inhibits advanced human prostate carcinoma growth in athymic nude mice, and increases plasma IGFBP-3 levels. Proc. Am. Assoc. Cancer Res., 43:166, 2002.

130. Dhanalakshmi, S., Agarwal, P., Glode, L.M. and Agarwal, R.: Silibinin sensitizes DU145 prostate carcinoma cells to cisplatin- and carboplatin-induced growth inhibition and apoptotic cell death. Proc. Am. Assoc. Cancer Res., 43:584, 2002.

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131. Tyagi, A.K., Agarwal, R. and Agarwal, C.: Procyanidin B3, isolated from grape seed extract, induces strong growth inhibition and apoptotic death of human prostrate carcinoma DU145 cells. Proc. Am. Assoc. Cancer Res., 43:641, 2002.

132. Tyagi, A., Agarwal, R. and Agarwal, C.: Grape seed extract inhibits the activation of both constitutive and EGF-induced MAPK-Elk1-AP1 signaling pathway in human prostrate carcinoma DU145 cells. Proc. Am. Assoc. Cancer Res., 43:642, 2002.

133. Agarwal, C., Singh, R.P. and Agarwal, R.: Grape seed extract-induced apoptotic death of prostate carcinoma DU145 cells: Involvement of caspases activation via cytochrome C release. Proc. Am. Assoc. Cancer Res., 43:642, 2002.

134. Dhanalakshmi, S., Singh, R.P., Agarwal, C. and Agarwal, R.: Silibinin inhibits constitutive and TNF-induced activation of NF-B and sensitizes human prostate carcinoma DU145 cells to TNF-induced apoptosis. Proc. Am. Assoc. Cancer Res., 43:642, 2002.

135. Lu, J., Wang, Z., Tyagi, A. and Agarwal, R.: Lack of preventive effect of dietary silymarin on 1-methyl-1-nitrosourea-induced rat mammary carcinogenesis: Is organ site specificity implied? Proc. Am. Assoc. Cancer Res., 43:823, 2002.

136. Agarwal, R.: Modulation of cell cycle regulators in prostate cancer prevention by silibinin. The Cell Cycle as a Target in Chemoprevention and Cancer Therapy Conference, 3rd International Conference, Austin, TX, October 2002.

137. Qi, L., Singh, R, Harrison, G.S., Agarwal, R. and Glode, L.M.: The EGF receptor is necessary and sufficient to mediate silibinin mediated cytotoxicity in transfected 9L glioma cells. ASCO Molecular Therapeutics Symposium, San Diego, CA, November 8-10, 2002.

138. Kim, N.-C., Graf, T. N., Oberlies, N. H., Wani, M. C., Wall, M. E., Agarwal, C., Agarwal, R. and Kroll, D. J.: Selective activity of pure flavonolignans from milk thistle (Silibum marianum) against human prostate carcinoma cell lines. Proc. Am. Assoc. Cancer Res., 44:105, 2003.

139. Singh, R.P., Sharma, G., Mallikarjuna, G. U., Dhanalakshmi, S., Agarwal, C. and Agarwal, R.: Inositol hexaphosphate inhibits advanced human prostate tumor growth and angiogenesis in athymic nude mice. Proc. Am. Assoc. Cancer Res., 44:200, 2003.

140. Agarwal, C., Dhanalakshmi, S., Singh, R. P. and Agarwal, R.: Antiangiogenic effect of grape seed extract in human prostate cancer xenograft in athymic nude mice. Proc. Am. Assoc. Cancer Res., 44:221, 2003.

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141. Tyagi, A. K., Singh, R. P., Agarwal, C., Shroyer, K., Glode, L. M. and Agarwal, R.: Silibinin down-regulates survivin mRNA and protein expression accompanied by G2-M arrest and apoptosis in human bladder transitional-cell papilloma RT4 cells. Proc. Am. Assoc. Cancer Res., 44:223, 2003.

142. Agarwal, R.: Silibinin and prostate cancer-targeting EGFR. Proc. 21st Annual Meeting, Mountain West Society of Toxicology – Toxicology and Natural Products. September 2003, Breckenridge, CO.

143. Roy, S., Agarwal, C., Dhanalakshmi, S. and Agarwal, R.: Antiproliferative effect of inositol hexaphosphate on rat prostate cancer cells. Proc. 21st Annual Meeting, Mountain West Society of Toxicology – Toxicology and Natural Products. September 2003, Breckenridge, CO.

144. Agarwal, R.: Molecular mechanism of silibinin efficacy in prostate cancer. 8th World Congress on Advances in Oncology, October 2003, Crete, Greece.

145. Majeed, N., Blouin, M.-J., Agarwal, R., Greenberg, N. and Pollak, M.: Oral feeding of silibinin reduces in vivo prostate cancer incidence and circulating IGF-1 in the TRAMP transgenic model. Proc. Second Annual AACR International Conference on Cancer Prevention Research: Frontiers in Cancer Prevention Research, A183, October 2003, Phoenix, AZ, Cancer Epidemiol. Biomarkers Prev., 12 :1297S-1298S, 2003.

146. Singh, R.P. and Agarwal, R.: Silibinin inhibits growth and causes apoptotic death of endothelial cells via modulation of survivin and mitochondrial apoptosis. AACR Special Conference on Angiogenesis, October 2003, Chicago, IL.

147. Kaur, M., Agarwal, C., Singh, R.P., Dwivedi, C., Guan, X. and Agarwal, R.: Alpha-santalol induces apoptotic cell death in human epidermoid carcinoma A431 cells. Proc. Am. Assoc. Cancer Res., 45:167, 2004.

148. Singh, R.P., Agrawal, P., Yim, D. and Agarwal, R.: Growth inhibitory and apoptotic effects of linarin, linarin acetate and acacetin on human prostate carcinoma cells. Proc. Am. Assoc. Cancer Res., 45:171, 2004.

149. Dhanalakshmi, S., Mohan, S., Singh, R.P., Mallikarjuna, G.U. and Agarwal, R.: Silibinin enhances UVB-induced apoptosis in human epidermoid carcinoma A431 cells via proapoptotic mitochondrial proteins and caspases activation. Proc. Am. Assoc. Cancer Res., 45:315, 2004.

150. Dhanalakshmi, S., Agarwal, C. and Agarwal, R.: Silibinin enhances UVB-induced MAPK/Erk1/2 activation, p53-ser 15 phosphorylation and accumulation in mouse epidermal JB6 cells: Possible role in protection against photocarcinogenesis. Proc. Am. Assoc. Cancer Res., 45:318-319, 2004.

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151. Singh, R.P., Mallikarjuna, G.U., Sharma, G., Dhanalakshmi, S., Tyagi, A., Chan, D., Agarwal, C. and Agarwal, R.: Silibinin reduces toxicity and enhances therapeutic efficacy of doxorubicin in lung cancer. Proc. Am. Assoc. Cancer Res., 45:460, 2004.

152. Mallikarjuna, G.U., Dhanalakshmi, S., Singh, R.P., Agarwal, C. and Agarwal, R.: Protective effects of silibinin against photocarcinogenesis in SKH-1 hairless mice. Proc. Am. Assoc. Cancer Res., 45:513, 2004.

153. Yim, D.S., Singh, R.P., Lee, S.Y., Agarwal, C. and Agarwal, R.: A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma DU145 cells. Proc. Am. Assoc. Cancer Res., 45:689, 2004.

154. Tyagi, A., Agarwal, C., Glode, L.M. and Agarwal, R.: Silibinin efficacy in human bladder transitional cell carcinoma: modulation of cell cycle and apoptosis cascades. Proc. Am. Assoc. Cancer Res., 45:730, 2004.

155. Agarwal, C. and Agarwal, R.: Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma LNCaP cells. Proc. Am. Assoc. Cancer Res., 45:902-903, 2004.

156. Dhanalakshmi, S., Mallikarjuna, G.U., Singh, R.P. and Agarwal, R.: Silibinin inhibits ultraviolet B-caused skin damage via up-regulation of p53 and p21/cip1 in SKH-1 hairless mice. Proc. Am. Assoc. Cancer Res., 45:932-933, 2004 (Mini-symposia).

157. Singh, R.P., Sharma, G., Dhanalakshmi, S., Glode, L.M. and Agarwal, R.: Silibinin inhibits human bladder transitional-cell papilloma RT4 tumor xenograft growth in athymic nude mice. Proc. Am. Assoc. Cancer Res., 45:1269-1270, 2004.

158. Agarwal, R.: Prostate Cancer Chemoprevention by Silibinin. Proceedings - Dietary Factors and Cancer Prevention: Current Premises and Future Promises, Rochester, MN, September 23-25, 2004.

159. Agarwal, R.: Prostate Cancer Prevention by IP6: Targeting Cell Cycle Regulation” Proceedings - IP6 and Cell Signaling in Fighting Cancer: From Laboratory to Clinic Symposium held at the 7th International Conference of Anticancer Research, Corfu, Greece, October 25-30, 2004.

160. Agarwal, R., Su, L.-J., Flaig, T., Harrison, G.S., Gustafson, D. and Glode, L.M.: A phase I clinical study of silibinin in patients with prosate cancer. Prostate Cancer Foundation (CapCure), October 2004.

161. Agarwal, C., Dhanalakshmi, S. and Agarwal, R.: Silibinin inhibits TNF-induced NF-B activation via IKK-IB pathway in human colon carcinoma cells: possible implications in colorectal cancer prevention and intervention. Proceedings 24th Annual Convention of IACR, New Delhi, India, February 9-12, 2005.

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162. Agarwal, R.: IP6 prevents prostate cancer by modulating cell cycle regulators. Proceedings 24th Annual Convention of IACR, New Delhi, India, February 9-12, 2005.

163. Kaur, M., Agarwal, R. and Agarwal, C.: Grape Seed Extract induces apoptosis in human prostate carcinoma LNCaP cells: possible roles of anoikis, and mitogen-activated protein kinases and caspases activation. Proc. Am. Assoc. Cancer Res., 46:365, 2005.

164. Agarwal, R., Mallikarjuna, Gu., Dhanalakshmi, S., Mohan, S. and Singh, R.P.: Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated proliferation and apoptosis in SKH-1 mouse skin: implications for the prevention of photocarcinogenesis. Proc. Am. Assoc. Cancer Res., 46:575, 2005.

165. Roy, S., Kaur, M., Agarwal, C., Singh, R.P. and Agarwal, R.: Role of cyclin-dependent kinase inhibitors p21 and p27 in silibinin-induced G1 arrest in DU145 prostate cancer cells. Proc. Am. Assoc. Cancer Res., 46:575, 2005.

166. Tyagi, A., Agarwal, C. and Agarwal, R.: Silibinin induces apoptosis in human bladder transitional cell papilloma RT4 cells by activating p53 and Chk2 in an ATM-dependent manner and cleavage of Bid. Proc. Am. Assoc. Cancer Res., 46:575-576, 2005.

167. Deep, G., Singh, R.P., Agarwal, C., Kroll, D.J. and Agarwal, R.: Distinct efficacy of silibinin in causing G1 and G2-M arrests via cyclins-CDK-CDK inhibitors and Chk2-Cdc25C-Cdc2-cyclin B1 circuitries in human prostate cancer PC3 cells - comparison with crude form silymarin. Proc. Am. Assoc. Cancer Res., 46:576, 2005.

168. Mohan, S., Dhanalakshmi, S., Singh, R.P., Agarwal, C. and Agarwal, R.: Silibinin inhibits UVB- and EGF-induced mitogenic MAPK-AP1 and cell survival Akt-NF-kB signaling in mouse epidermal JB6 cells: Possible role in protection against skin tumor promotion. Proc. Am. Assoc. Cancer Res., 46:576, 2005.

169. Singh, R.P., Varghese, L., Dhanalakshmi, S. and Agarwal, R.: In vitro as well as in vivo anticancer efficacy of silibinin against human pancreatic cancer BxPC-3 and Panc-1 cells. Proc. Am. Assoc. Cancer Res., 46:579-580, 2005.

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170. Mallikarjuna, G.U., Dhanalakshmi, S., Mohan, S., Singh, R.P. and Agarwal, R.: Protective efficacy and associated mechanisms of silibinin against UVB-induced skin tumorigenesis in SKH-1 hairless mice. Proc. Am. Assoc. Cancer Res., 46:1016, 2005.

171. Agarwal, C., Veluri, R., Thompson, J.A. and Agarwal, R.: Biofractionation of GSE: Identification of gallic acid as one of the major active constituents causing growth inhibition, S phase arrest and apoptotic death of DU145 human prostate carcinoma cells. Proc. Am. Assoc. Cancer Res., 46:1227, 2005.

172. Varghese, L., Agarwal, C., Tyagi, A. and Agarwal, R.: Silibinin induces cell cycle arrest in human hepatocellular carcinoma HepG2 and Hep3B cells by modulating cyclin-cyclin dependant kinase-cyclin dependant kinase inhibitor levels and activity. Proc. Am. Assoc. Cancer Res., 46:1231-1232, 2005.

173. Chitterzhath, M., Singh, R.P., Agarwal, C. and Agarwal, R.: Silibinin inhibits cytokines-induced STATs, MAPKs and NF-B activation and down regulates HIF-1 and iNOS in human lung epithelial A549 cells: Possible role in angioprevention of lung tumorigenesis. Proc. Am. Assoc. Cancer Res., 46:1232, 2005.

174. Flaig, T., Agarwal, R., Su, L.J., Harrison, G.S., Gustafson, D. and Glode, L.M.: A phase I study of silibinin in hormone refractory prostate cancer. J. Clin. Oncol. 23:427s, 2005.

175. Veluri, R., Agarwal, R., Thompson, J.A. and Agarwal, C.: LC/MS identification of gallic acid and procyanidins from grape seeds with anti-cancer activity in DU145 human prostate carcinoma cells. Proc. Annual Meeting of the Amer. Chem. Soc., 2005.

176. Agarwal, R.: Prostate cancer prevention by silibinin – bench to bedside. Proceedings: Targeting Carcinogenesis, Rochester, MN, October 6 th to 7th, 2005.

177. Agarwal, R.: Modulation of cell cycle regulators in prostate cancer prevention by silibinin. Proceedings, 3rd Joint Meeting of the Society for Free Radical Research Australia and Japan, Gold Coast, December 2-5, 2005, page 44.

178. Agarwal, C., Dhanalakshmi, S. and Agarwal, R.: Silibinin inhibits NF-kB activation via IKKalpha-IkBalpha in human colorectal carcinoma cells. Proceedings, 3rd Joint Meeting of the Society for Free Radical Research Australia and Japan, Gold Coast, December 2-5, 2005, page 128.

179. Flaig, T., Su, L.J., Harrison, G., Agarwal, R. and Glodé, L.M.: Silibinin synergizes with mitoxantrone to decrease cell viability in prostate cancer cells. ASCO, 2006.

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180. Kaur, M., Agarwal, R. and Agarwal, C.: Grape seed extract induces cell cycle arrest via up-regulation of p21Waf1 and down-regulation of cyclins-cyclin dependent kinases, and causes apoptotic death of human colorectal carcinoma LoVo, HT29 and SW480 cells. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.

181. Raina, K., Katiyar, S., Agarwal, C. and Agarwal, R.: Silibinin inhibits ligand-induced EGFR and Akt phosphorylation, and causes cell cycle arrest and apoptosis in human colorectal carcinoma SW480 cells. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.

182. Singh, R. P., Sharma, G. and Agarwal, R.: Silibinin consumption inhibits prostate tumor growth in transgenic adenocarcinoma of mouse prostate (TRAMP) mice. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.

183. Gu, M., Dhanalakshmi, S., Singh, R.P., Agarwal, C. and Agarwal, R.: Silibinin inhibits UVB-induced skin tumorigenesis by down-regulating STAT3 and NF-κB activation. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.

184. Roy, S. and Agarwal, R.: Protective effect of silibinin against ultraviolet B radiation-induced apoptosis in mouse epidermal JB6 cells involves prolonged p53 serine15 phosphorylation. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.

185. Deep, G., Oberlies, N.H., Kroll, D.J. and Agarwal, R.: Isosilybin B causes androgen receptor degradation via PI3K-Akt-Mdm2 pathway leading to a decrease in prostate specific antigen and cell cycle arrest in LNCaP human prostate carcinoma cells. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.

186. Gu, M., Dhanalakshmi, S., Singh, R.P., Agarwal, C. and Agarwal, R.: Inositol hexaphosphate down-regulates both constitutive and ligand-induced mitogenic and cell survival signaling, and causes caspase-mediated apoptotic death of human prostate carcinoma PC3 cells. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.

187. Tyagi, A., Tyagi, A., Chan, D., Agarwal, C. and Agarwal, R.: Grape seed extract sensitizes human breast carcinoma cells to chemotherapy agents-induced growth inhibition and apoptotic death via cytochrome c release and caspase activation pathway. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.

188. Agarwal, C., Tyagi, A. and Agarwal, R.: Gallic acid, the major active constituent in grape seed extract, causes S phase arrest via activation of ATM-Chk1/2-Cdc25A/C-Cdc2 pathway, and leads to caspase-mediated apoptotic death of human prostate carcinoma DU145 cells. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.

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189. Agarwal, R.: Skin Cancer Prevention by Silibinin. International Conference: Frontiers of Pharmacology and Toxicology, Chicago, IL, August 29 th, 2006. Chemico-Biological Intercations, 161: S26, 192-193, 2006.

190. Graf, T.N., Kroll, D.J., Agarwal R., Wani, M.C. and Oberlies, N.H.: Preparation of large-scale samples of the major bioactive constituents in milk thistle (Silybum marianum (L.) Gaertn.) for preclinical investigations of prostate cancer chemoprevention and treatment. 2006 AACR International Conference on Frontiers in Cancer Prevention Research, Boston, MA.

191. Pappa, A., Milikowsky, J.M., Agarwal, R., Wani, M.C., Oberlies, N.H. and Kroll, D.J.: Flavonolignans from extracts of milk thistle (Silybum marianum) suppress biomarkers of prostate oncogenesis and colon carcinoma cell proliferation independently of p53 or p21. 2006 AACR International Conference on Frontiers in Cancer Prevention Research, Boston, MA.

192. Agarwal, R.: Molecular mechanism of prostate cancer prevention by a dietary nutrient inositol hexaphosphate. Proc. of The 3rd APOCP Conference “Empowering Cancer Prevention in the Asian Pacific”, Bangkok, Thailand, November 3-5, 2006.

193. Agarwal, R.: Prostate cancer prevention by silibinin: how close we are to bedside? International Radiation Oncology Conference Special Session on Cancer Chemoprevention, Varanasi, India, Abstract #180, November 20-22, 2006.

194. Agarwal, C. and Agarwal, R.: Grape seed extract inhibits human colorectal carcinoma growth by inducing Cip1/p21, cell cycle arrest and apoptosis. International Radiation Oncology Conference Special Session on Cancer Chemoprevention, Varanasi, India, Abstract #179, November 20-22, 2006.

195. Agarwal, R.: Prostate cancer prevention by flavonoid silibinin. 4th Bio/Molecular Informatics Center International Symposium entitled “Flavonoids: old subjects but new challenges” held at Konkuk University, Seoul, Korea; February 7, 2007.

196. Agarwal, R.: Molecular mechanism of prostate cancer prevention by a dietary nutrient inositol hexaphosphate” at Natural Products, Diets and Cancer Prevention Session of the American Chemical Society Natioanl Meeting, Chicago, IL. March 25th, 2007.

197. Tewari-Singh, N., Rana, S., Gu, M., Agarwal, C., Day, B.J., White, C.W. and Agarwal, R.: Biological and Molecular markers for CEES-induced skin injury in JB6 cells. 1st Annual CounterACT Network Research Symposium, April 25-27, 2007, Arlington VA.

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198. Rana, S., Tewari-Singh, N., Gu, M., White, C.W. and Agarwal, R.: In Vivo studies to develop CEES-induced skin toxicity models. 1st Annual CounterACT Network Research Symposium, April 25-27, 2007, Arlington VA.

199. Agarwal, C., Veluri, R., Kaur, M., Chou, S.-C., Thompson, J.A. and Agarwal, R.: Fractionation of high molecular weight tannins in grape seed extract and identification of procyanidin B2-3,3’-di-O-gallate as a major active constituent causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Mini-symposium Preclinical Prevention Studies 1: Novel Agents. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

200. Raina, K., Singh, R. P., Agarwal, R. and Agarwal, C.: Chemoprevention of prostate cancer by grape seed extract in a transgenic mouse model. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

201. Agarwal, R., Agarwal, C. and Tyagi, A.: Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

202. Tyagi, A., Singh, R.P., Agarwal, C., Harrison, G., Glode, M.L. and Agarwal, R.: Chemopreventive effect of silibinin and silymarin on n-butyl-n-(4hydroxybutyl) nitrosamine-induced urinary bladder carcinogenesis in male ICR mice. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

203. Singh, R.P., Deep, G. and Agarwal, R.: Dietary feeding of silibinin inhibits PC-3 tumor xenograft growth via ERK1/2 activation and an increase in Cip1/p21 and Kip1/p27 expression. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

204. Deep, G., Oberlies, N.H., Kroll, D.J. and Agarwal, R.: Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

205. Gu, M., Singh, R. P. and Agarwal, R.: Silibinin inhibits in vivo growth of colorectal cancer by inhibiting tumor cell proliferation and angiogenesis in athymic nude mice. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

206. Kaur, M., Agarwal, R. and Agarwal, C.: Gallic acid, a major active constituent of grape seed extract, induces apoptotic death via the activation of p38 MAPK pathway in human prostate carcinoma DU145 cells. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

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207. Dwyer-Nield, L.D., Singh, R.P., Tyagi, A., Malkinson, A.M. and Agarwal, R.: Therapeutic efficacy of silibinin on chemically-induced mouse lung tumors. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

208. Roy, S. and Agarwal, R.: Silibinin inhibits apoptosis, reduces DNA lesions and modulates cell cycle events in a p53-dependent manner in ultraviolet B-irradiated mouse epidermal JB6 cells. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

209. Balaiya, V., Singh, R.P., Tyagi, A. and Agarwal, R.: Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

210. Mateen, S., Tyagi, A. and Agarwal, R.: Anti Cancer Efficacy of Silibinin and Erlotinib in human Non-small-cell lung cancer cells. 25th Annual Meeting of the Mountain West Society of Toxicology, Breckenridge, CO, September, 2007.

211. Roy, S. and Agarwal, R.: Silibinin protects against UVB-induced damage by regulating cell cycle events, DNA repair and apoptosis in a P53- and GADD45-dependent manner. 25th Annual Meeting of the Mountain West Society of Toxicology, Breckenridge, CO, September, 2007.

212. Agarwal, R.: Recent advances in mechanism of cancer chemoprevention by grape seed extract. 12th World Congress on Advances in Oncology and 10th International Symposium on Molecular Medicine: Bioactive Food Components, Alternative Medicine and Cancer Chemoprevention: Recent Advances. Crete, Greece, October, 2007.

213. Agarwal, R.: Lung cancer chemoprevention by silibinin. 9th International Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis. Jeju Island, S. Korea, December 1-5, 2007.

214. Agarwal, R.: Chemoprevention of Prostate Cancer by Silibinin: Bench to Bedside. 18th All India Congress of Zoology and SCIAZE, University of Lucknow, Lucknow, India, December 7-9, 2007.

215. Agarwal, R.: Silibinin and Angioprevention – an upcoming strategy. 2nd International Symposium on Translational Research on Natural Products and Cancer. Lonavala, Mumbai, India, December 9-12, 2007.

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