CURRICULUM VITAE

John Reginald STRADLING

Consultant Physician and Professor of Respiratory Medicine

Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford Radcliffe Hospitals NHS Trust, Headington, Oxford. Telephone 01865225236, email john.stradling@orh.nhs.uk The Ridings, High Street, Beckley, Oxon. OX3 9UU Telephone 01865351623 H, 07831604811 M DATE OF BIRTH: 31/1/52 Place of birth: London Nationality: British Married, three children. My wife is a principal partner in general practice (Bratby, Kotnis & McBeath, Temple Street Surgery, Oxford). SCHOOLING : St Paul’s, London. Foundation Scholar HOSPITAL where trained: Middlesex Hospital DEGREES and QUALIFICATIONS:

1973: BSc, (1st class honours) London 1976: MB BS, (with honours) London 1976: ECFMG HIGHER QUALIFICATIONS:

1978: MRCP (UK) 1981: MD (London) 1992: FRCP (London) 1999: Chair or Respiratory Medicine (Oxford) STUDENT DISTINCTIONS and PRIZES

1971: 1st year overall prize 1972: 1st physiology prize (Sydney Kaye)

1st biochemistry prize (Cayley) Meyerstein Scholar (1 of 3) 1973: 1st BSc prize (Colin McKenzie) 1973: 1st clinical year prize 1976: Qualified with honours (Pharmacology and Therapeutics) Non medical interests: Music (classical trumpet)

POSTGRADUATE APPOINTMENTS AND EXPERIENCE

1/2/77 - 31/7/77 House Physician Middlesex Hospital F Scadding and S Semple General Medicine 1/8/77 - 31/1/78 House Surgeon Taunton Hospital C Collins and G Lumb General surgery 1/2/78 - 31/7/78 Senior House Officer Hammersmith Hospital C Dollery and J Reid Clinical Pharmacology and General Medicine 1/8/78 - 31/7/79 Senior House Officer Oxford Hospitals J Badenoch, D Hockaday, B Gribbin,

D Lane, L Wollner, S McCarthy On take general medicine with several specialities. 1/8/79 - 28/2/81 Honorary (research) Churchill, Oxford registrar, DJ Lane. Mainly research but locum duties, outpatients and unit meetings. 1/3/81 - 1/1/83 Registrar,Department Hammersmith Hospital of Medicine. GW Poole, JMB Hughes, NB Pride 2/1/83 - 31/10/85 Senior Registrar Oxford Hospitals Respiratory and general medicine. M Benson, DJ Lane, Sir J Badenoch, B Gribbin. 9/9/84-14/9/85 MRC Travelling University of Toronto Research Fellow Professor EA Phillipson 1/11/85-31/3/89 Wellcome Senior University of Oxford Research Fellow and Consultant physician

Current posts

1/4/89- Consultant Respiratory Physician Churchill Chest UnitEmployed by Oxford Radcliffe Hospitals NHS Trust (part time from 2013)

1/10/99- Professor of Respiratory Medicine University of OxfordPersonal honorary chairEmeritus Professor from 2013

SPECIALIST TRAINING (clinical procedures) General medicine

Liver biopsy. Central venous catheterization. Respiratory Pleural biopsies/chest drains Per-cutaneous biopsy of lung lesions under x-ray control, (have radiation certificate). Both flexible (local anaesthesia) and rigid (general anaesthesia) bronchoscopy. Complex lung function testing. Sleep studies for the diagnosis of sleep related respiratory disorders.

MEMBER OF FOLLOWING SOCIETIES

British Thoracic Society British Sleep SocietyEuropean Respiratory Society Sleep Research SocietyEuropean Sleep Research Society

Previous co-chairman of the Sleep and Breathing Disorders working group, SEPCR Previous honorary secretary of the Breathing Club Ex Chairman, British Sleep Society

PUBLICATIONS 1972-1985 1) Mechanisms of urinary concentration and Control of body fluid volume. Tape-slide programmes for University of London, 1972. 2) a) Control of breathing: a programmed text. Stradling JR, McBeath HA, Fournier-Massey GG, Massey DG. Universite de Sherbrooke 1972 b) Mechanics of the respiratory system: a programmed text Massey DG, Stradling JR, McBeath HA, Fournier-Massey GG. Universite de Sherbrooke 1972 c) Pharmacology of the respiratory system: a programmed text. Massey DG, McBeath HA, Stradling JR, Fournier-Massey GG. Universite de Sherbrooke 1973 d) Respiratory immunology: a programmed text Stradling JR, Fournier-Massey GG, Massey DG. University of Hawaii 19753) Hazards of Dextrostix (Letter). Stradling JR. Lancet 1976;2:6904) *Heparin and infusion phlebitis. Stradling JR. BMJ 1978;2:1195-11965) Polycythaemia and nocturnal hypoxaemia (Letter) Stradling JR, Lane DJ. BMJ 1980;1:4046) Apnoea alarms. Description of a new design. Stradling JR. Lancet 1980;1:11977) Sleep apnoea syndrome caused by neurofibromatosis and superior venacaval obstruction. Stradling JR, Huddart S, Arnold AG. Thorax 1981;36:634-635 8) Development of secondary polycythaemia in chronic airways obstruction (Review) Stradling JR, Lane DJ. Thorax 1981;36:321-325 9) Upper airways obstruction as a cause of pulmonary oedema. Stradling JR, Bolton P. Lancet

1982;1:1353-135410) Avoidance of tracheostomy in sleep apnoea syndrome. Stradling JR. BMJ 1982;285:407-40811) *The effects of almitrine on the ventilatory response to hypoxaemia and hypercapnia in normal

subjects. Stradling JR, Barnes P, Pride NB. Clinical Science 1982;63:401-404 12) *The accuracy of the Hewlett-Packard Oximeter below 50% SaO2 Stradling JR. Clin Resp Physiol 1982;18:791-794 13) Obstructive sleep apnoea syndrome (leading article). Stradling JR. BMJ 1982;285:528-53014) *Nocturnal hypoxaemia in chronic obstructive pulmonary disease. Stradling JR, Lane DJ. Clinical Science 1983;64:213-222 15) *Quantitative measurement of intrapulmonary and extrapulmonary right to left shunt in humans and

dogs. Jones HA, Stradling JR, Clark JC, Davies EE, Rozkovec A. Journal of Applied Physiology 1983;54:1434-38

16) *Speed of response and accuracy of two transcutaneous carbon dioxide monitors. Stradling JR, Nicholl CG, Cover D, Hughes JMB. Clin. Resp. Physiol. 1983;19:407-1017) Respiratory Physiology in Labour. Stradling JR. J.Assoc. Chartered Physio. Obs. & Gynae

1983;53:5-718) Warning - snoring can damage your health. Stradling JR. Update 1984;28:557-56419) *The effects of almitrine on pattern of breathing and gas exchange in patients with chronic

obstructive pulmonary disease. Stradling J, Nicholl C, Cover D, Davies E, Hughes J, Pride N. Clinical Science 1984; 66:435-44220) Respiratory Physiology during labour.

Stradling JR. Midwife, Health Visitor and Community Nurse. 1984;20:38-42

21) Pattern of breathing and gas exchange following oral almitrine in patients with chronic obstructive pulmonary disease. Stradling J, Nicholl C, Cover D, Davies E, Hughes J, Pride N. European Journal of Resp Dis 1983;suppl 126;64:255-64

22) Six respiratory cases from the clinics. Stradling JR. Update 1984;29:295-298&631-634 23) *Changes in ventilation and its components in normal subjects during sleep. Stradling JR, Chadwick

GA, Frew AJ. Thorax 1985; 40:364-70 24) *Respiratory inductance plethysmography:calibration techniques, their validation and the effects of

posture. Stradling JR, Chadwick G, Quirk C & Phillips T. Bull Resp Phys Path 1985;21:317-24198625) Sleep related disorders of breathing. Stradling JR.

New chapter for 2nd Edition of the Oxford Text Book of Medicine. March 1987;pages 15.158-61. Rewritten for 3rd edition, 1994.2

26) Breathing Disorders During Sleep, (requested review). Stradling JR, Phillipson EA. Quart J Med 1986;58:3-1827) Hypercapnia during oxygen therapy in chronic airways obstruction. Stradling JR. Thorax

1986;41:897-902.28) Controversies in sleep-related breathing disorders, (requested review). Stradling JR. Lung

1986;164:17-3129) *Respiratory activity of laryngeal muscles in awake and sleeping dogs.

Harding RW, England SJ, Stradling JR, Kozar LF, Phillipson EA. Respiration Physiology 1986;66:315-26

30) *Laryngeal muscle activities during progressive hypercapnia and hypoxia in awake and sleeping dogs.

England SJ, Harding RW, Stradling JR, Phillipson EA. Respiration Physiology 1986;66:327-39198731) *Role of the upper airway in ventilatory control in awake and sleeping dogs.

Stradling J, England S, Harding R, Kozar L, Andrey S, Phillipson EA. J Appl Physiol 1987;62:1167-7

32) *The effect of acute bilateral diaphragm paralysis in awake and sleeping dogs. Stradling JR, Kozar L, Dark J, Kirby T, Andrey S, Phillipson EA. Am Rev Respir Dis 1987;136:633-7

33) Radioactive isotope lung scanning. Stradling JR, McBeath HA. Update March 1, 1987;34:521-52434) Diagnostic Bronchoscopy. P Stradling. Assistant Author (Fibreoptic Bronchoscopy, Chapter 3), J Stradling, 1987 & 199135) Using a peak flow meter in general practice. McBeath HA, Stradling JR. Update 1987;35:1076-8036) *Evaluation of the Ohmeda 3700 pulse oximeter. Warley ARH, Stradling JR, Mitchell J. Thorax 1987;42:892-6 37) Wrist actigraphic assessment of sleep. Stradling JR, Warley ARH, Sharpley A. Sleep Research

1987;16:58638) Obstructive sleep apnoea and lower airways obstruction. Lancet leading article, 1987;ii:774-6198839) Bilateral Diaphragm Paralysis and sleep apnoea without diurnal respiratory failure. Stradling JR, Warley ARH. Thorax 1988;43:75-7 40) *Systemic pulmonary hypertension: pathophysiology and haemodynamic response to vasodilators. Rozkovec A, Stradling J, Shepherd G, MacDermot J, Oakley C, Dollery C. British Heart Journal

1988;59:696-70541) *Abnormal diurnal variation in salt and water excretion in patients with obstructive sleep apnoea. Warley ARH, Stradling JR. Clinical Science 1988;74:183-5 42) *Should Ipratropium Bromide be added to beta-agonists in acute asthma? Higgins R, Stradling JR, Lane DJ. Chest 1988;94:718-72243) *Prevalence of nocturnal hypoxaemia in men with and without hypertension. Warley ARH, Mitchell AH, Stradling JR. QJM 1988;68:637-44 44) *Do sleep studies contribute to the management of patients with severe chronic bronchitis and

emphysema? Connaughton J, Catterall J, Elton R, Stradling J, Douglas N. Amer Rev Respir Dis 1988;138:341-4

45) *Analysis of overnight sleep patterns by automatic detection of movement on video recordings. Stradling JR, Thomas G, Belcher R. J Amb Mon 1988;1:217-22

198946a) Control of breathing. Stradling JR. Chapter for a new textbook of respiratory medicine. Eds Gibson

J, Geddes D, Brewis A. 1989. Rewritten for 2nd edition 1995. 46b) Disorders of the control of breathing. Stradling JR. Chapter for above book.47) *Oximetry versus polysomnography in the diagnosis of sleep disorders. Stradling JR, Warley ARH,

Sharpley A, Apps M, Calverley PMA, Chadwick G, McNicholas W. J. Amb Mon 1989;2:197-20148) *Ventilatory response to a steady state CO2 load and added deadspace in man, awake and asleep.

Warley ARH, Clarke M, Phillips T, Stradling JR. Respir Physiol 1989;75:183-9249) *Reproducibility of home oximetry tracings. Stradling JR, Mitchell J. J Amb Mon 1989;2:203-20850) Oximetry studies alone for sleep and breathing disorders? Stradling JR. Current Medical Literature (RSM) 1989;3:3-851) Sleep apnoea and driving. Stradling JR. Requested leader BMJ 1989;298:904-552) Sleep apnoea and snoring. Stradling JR. In Sleep Disorders, eds. Horne J and Page M, 198953) Sleep apnoea and hypertension. Requested Editorial. Stradling JR. Thorax 1989;44:984-8954) Sleep apnoea. Requested Editorial. Stradling JR. Care of the Critically Ill 1989;5:134-138199055) *The effect of acetazolamide on hypercapnic and eucapnic hypoxic ventilatory responses in normal

subjects. Bashir Y, Kann M, Stradling J. Respir Pharmacol 1990;3:151-56) *Lack of effect of an inspiratory threshold load on plasma ANP levels. Warley ARH, Fontes F, Wilson M, Raine T, Stradling JR. Clin Sci 1990;78:311-1357) Clinical presentation of sleep apnoea. Stradling JR. Eur Respir J 1990;3(suppl 11):548-9s58) *Effect of adenotonsillectomy on nocturnal hypoxaemia, sleep disturbance and symptoms in snoring

children. Stradling JR, Thomas G, Williams P, Warley ARH, Freeland A. Lancet 1990;335:249-253

59) *The relationship between neck circumference, radiographic pharyngeal anatomy, and the obstructive sleep apnoea syndrome. Davies, RJO, Stradling JR. Eur Resp J 1990;3:509-14

60) *Relationship between systemic hypertension and sleep hypoxaemia or snoring: analysis of 748 men drawn from general practice. Stradling JR, Crosby J. BMJ 1990;300:75-78

61) *Do patients with obstructive sleep apnoea have fat necks? Katz I, Stradling J, Slutsky AS, Zamel N, Hoffstein V. Am Rev Respir Dis 1990;141:1228-3162) Treatment of sleep apnoea by vertical gastroplasty. Summers CL, Stradling JR, Badderly M. Brit J Surgery 1990;77:1271-263) Ear involvement in the yellow nail syndrome. Armitage JM, Lane DJ, Stradling JR, Burton M. Chest 1990;98:1534-35199164) *Systolic blood pressure swings reflect inspiratory effort during simulated obstructive sleep apnoea.

Lea S, Ali NJ, Goldman M, Loh L, Fleetham J, Stradling JR. Sleep 90;178-181. Pontenagel Press, 1991.

65) Respiratory Sleep Disorders. Ali NJ, Stradling JR. Medicine International 1991;91:3789-9366) *Periodic movements of the legs during sleep associated with rises in systemic blood pressure. Ali NJ, Davies RJO, Fleetham JA, Stradling JR. Sleep 1991;14:163-567) *Prevalence of obstructive sleep apnoea in 1001 middle-aged men. Stradling JR, Crosby J. Thorax 1991;46:85-9068) *Snoring and daytime sleepiness in 900 men aged 35-65 years. Stradling JR, Crosby J. Thorax 1991;46:807-81069) *Assessment of sleep times and movement arousals from video recordings. Vos PJE, Stradling JR. J Amb Mon 1991;4:35-4270) Prevalence of sleep apnoea in 1001 men aged 35-65 years. Stradling JR, Crosby J. Sleep 90;170-3. Pontenagel press, 1991.71) Systemic hypertension and sleep apnoea. Stradling JR. In: Sleep and Cardiorespiratory Control,

pp 115-122 INSERM/John Libbey, Eurotext 1991.199272) *Prevalence of sleep apnoea in patients over forty years of age with spinal cord lesions. Short DJ, Stradling JR, Williams SJ. J Neurol Neurosurg Psych 1992;55:1032-6 73) *The acute affects of continuous positive airway pressure, and oxygen administration on blood

pressure during obstructive sleep apnoea. Ali NJ, Davies RJO, Fleetham JA, Stradling JR. Chest 1992;101:1526-1532

74) *Neck circumference and other clinical features in the diagnosis of the obstructive sleep apnoea syndrome. Davies RJO, Ali N, Stradling JR. Thorax 1992;47:101-105

75) *Nocturnal hypoxia and arrhythmias in patients with impaired left ventricular function. Cripps T, Rocker G, Stradling JR. British Heart Journal 1992;68:382-38676) An artifact induced by negative pressure ventilation. Goldstein RS, Stradling JR. Chest

1992;101:563-56577) Sleep studies for sleep-related breathing disorders, a consensus report.

Stradling JR. J Sleep Research 1992;1:265-273199378) *The effect of arousals on blood pressure. Davies RJO, Belt P, Ali NJ, Stradling JR. J Appl Physiol 1993;74:1123-113079) *Snoring, sleep disturbance and behaviour in 4-5 year olds. Ali NJ, Pitson D, Stradling JR. Arch Dis Child 1993;68:360-36680) *Systolic blood pressure profiles in the diagnosis of sleep disruption and sleep disordered breathing. Davies RJO, Vardi-Visy K, Clarke M, Stradling JR. Thorax 1993;48:1242-47.81) *Chemoreceptor drives and short sleep-wake cycles during hypoxia: a simulation study. Saunders KB, Stradling JR. Annals of Bio-Medical Engineering 1993;21:465-47482) *Nasal continuous positive airway pressure in chronic heart failure with sleep-disordered breathing. Davies RJO, Harrington KJ, Ormerod JM, Stradling JR. Am Rev Respir Dis 1993;147:630-63483) Acute effects of obstructive sleep apnoea. Davies RJO, Stradling JR. Brit J Anaesthesia

1993;71:725-72984) *Pulse transit time as a measure of respiratory effort. Stradling JR, Brock J, Pitson D. J Amb Mon 1993;6:295-30285) Handbook of sleep-related disorders of breathing.

Stradling JR. 100,000 word, 300 page monograph (OUP). September 1993. Reprinted 1994 & 1997.

86) Obstructive sleep apnoea and blood pressure elevation. What is the relationship?Carlson J, Davies RJO, Ehlenz K, Grunstein R, Hedner J, Podzus T, Sinoway L, Stradling JR, Telakivi T, Zwillich C. Blood Pressure 1993;2:166-182

87) *Identification of sleep disruption and sleep disordered breathing from the systolic blood pressure profile. Davies RJO, Vardi-Visy K, Clarke M, Stradling JR. Thorax 1993;48:1242-124

88) Sleep and recreational drugs. BMJ series on the ABC of sleep (Ed. C Shapiro). BMJ 1993;306:573-576

199489) *Ambulatory blood pressure and left ventricular hypertrophy in untreated obstructive sleep apnoea

and snoring, compared to matched controls, and its response to treatment. Davies RJO, Crosby J, Prothero A, Stradling JR. Clinical Science 1994;86:417-42490) Structure and function of the upper respiratory tract. Stradling JR. New chapter for 3rd edition, Oxford Textbook of Medicine. 1994.91) Upper airway obstruction. Stradling JR. New chapter for 3rd edition, Oxford Textbook of Medicine. 1994.92) *Effect of measuring ambulatory blood pressure on sleep and on blood pressure during sleep. Davies RJO, Jenkins N, Stradling JR. BMJ 1994;308:820-82393) *Non-invasive beat to beat arterial blood pressure during non-REM sleep in obstructive sleep apnoea

and snoring. Davies RJO, Vardi-Visy K, Crosby J, Clarke M, Stradling JR. Thorax 1994;49:335-33994) *Plasma insulin and lipid levels in untreated obstructive sleep apnoea and snoring; their comparison

with matched controls and response to treatment. Davies RJO, Turner R, Crosby J, Stradling JR. J Sleep Res 1994;3:180-185

95) Recent advances in sleep apnoea. Stradling JR. Chapter in Horizons in Medicine (ed. Seymour and Weetman). Royal College of Physician & Blackwell Scientific, 1994.

96) *Changes in pulse transit time and pulse rate as markers of arousal from sleep in normal subjects. Pitson D, Chhina N, Knijn S, van Herwaaden M, Stradling JR. Clinical Science 1994;87:269-273

97) *The natural history of snoring and related behaviour problems between the ages of 4 and 7 years. Ali NJ, Pitson D, Stradling JR. Arch.Dis.Child.1994;49:335-339

199598) *Short and long term outcomes of uvulopalatopharyngoplasty for snoring.

Koay CB, Freeland AP, Stradling JR. Clin Otolaryngol 1995;20:45-4899) Respiratory problems during sleep. Stradling JR, Ali NJ. Medicine 1995;13(9):372-5

100) Epidemiology, definitions and natural history of obstructive sleep apnoea. Requested review for Stradling JR. Thorax 1995;50:683-689

101) Epidemiology and cardiovascular risk of snoring. Invited review for Monaldi Archives for Chest Disease. 1995;50:123-128

102) *Mechanism of pulse transit lengthening during obstructed inspiratory efforts. Pitson D, Chhina N, Knijn S, vanHerwaaden M, Stradling JR. J Amb Mon 1995;8:101-105

103) *Effects of short term high frequency negative pressure ventilation on gas exchange using the Hayek oscillator. Hardinge FM, Davies RJO, Stradling JR. Thorax 1995;50:44-49

104) *Pulse transit time as a measure of respiratory effort in patients with obstructive sleep apnoea.Pitson D, Sandell A, van de Hoot R, Stradling JR. European Respiratory Journal 1995;8:1669-1674.

105) *Use of the Epworth Sleepiness Scale to demonstrate response to treatment with nasal continuous positive airway pressure in patients with obstructive sleep apnoea.Hardinge FM, Pitson DJ, Stradling JR. Respiratory Medicine 1995;89:617-620

1996106) *Sleep disordered breathing: effects of adenotonsillectomy on behaviour and psychological

functioning. Ali NJ, Pitson D, Stradling JR. European Journal of Pediatrics 1996;155:56-62.107) *Effect of short term graded withdrawal of nasal continuous positive airway pressure on systemic

blood pressure in patients with obstructive sleep apnoea.Stradling JR, Partlett J, Davies RJO, Siegwart D, Tarassenko L. Blood Pressure 1996;5:234-240

108) Obstructive sleep apnoea and its effect on the pulmonary circulation. Stradling JR. Chapter for 'The Pulmonary Circulation', edited by Dr A Peacock. 1996.

109) *A new approach to the analysis of the human sleep-wakefulness continuum. Pardey J, Roberts S, Tarassenko L, Stradling JR. Journal of Sleep Research 1996;5:201-210

110) Is it necessary to record sleep? Stradling JR, Davies RJO. Sleep1996;19:S251-S254111) New approaches to monitoring sleep related breathing disorders.

Stradling JR, Davies RJO, Pitson DJ. Sleep 1996;19:S77-S84112) The Epidemiology of Sleep Apnoea. Davies RJO, Stradling JR. Thorax 1996;51(Suppl 2):S65-S701997113) *Automatic nasal continuous positive airway pressure titration in the laboratory, patient outcomes.

Stradling JR, Barbour C, Pitson DJ, Davies RJO. Thorax 1997;52:72-75114) Sleep apnoea and the misuse of evidence based medicine. Stradling JR. Lancet 1997;349:201-202115) Who should receive treatment for sleep apnoea? Bennett LS, Stradling JR. Thorax 1997;52:103-

104116) Practical approach to sleep disordered breathing. Stradling JR.

Chapter in Horizons in Medicine, ed Farthing M, volume 8, 1997; 233-248117) *A shorter form health survey: can the SF-12 replicate results from the SF-36 in longitudinal

studies? Jenkinson C, Layte R, Jenkinson D, Keoghane S, Lawrence K, Petersen S, Stradling J.J Public Health Med 1997;19:179-186

118) Sleep apnoea and hypertension - what a mess. Stradling J, Davies R. Sleep 1997;20:789-793119) *Comparison of three measures of outcome in the evaluation of continuous positive airway pressure

therapy for sleep apnoea. Jenkinson C, Stradling J, Petersen S. J. Sleep Research 1997;6:199-204120) Investigate the causes of sleepiness. Bennett L, Stradling J. Health and Ageing 1997;March;34-37.121) The unacceptable face of evidence-based medicine. Stradling JR, Davies RJO. J Evaluation Clin

Practice 1997;3:99-104122) *A behavioural test to assess daytime sleepiness in obstructive sleep apnoea. Bennett LS, Stradling

JR, Davies RJO. J Sleep Research 1997;6:142-145.1998123) Medical approaches to snoring and sleep apnoea. Stradling JR Trans Med Soc Lond

1997-98;114:17-9124) The role of CPAP in the sleep apnoea syndrome. Bennett L, Stradling JR. Current Medical

Literature (RSM) 1998;1195-102.125) *Mandibular positioning devices for the control of snoring. Stradling JR, Negus T, Smith D,

Langford B. European Respiratory Journal 1998;11:447-450126) *Controlled trial of hypnotherapy for weight loss in patients with obstructive sleep apnoea.

Stradling J, Roberts D, Wilson A, Lovelock F. International Journal of Obesity 1998;28:278-281127) *Sleep fragmentation indices as predictors of daytime sleepiness and CPAP response in

obstructive sleep apnea. Bennett LS, Langford B, Stradling JR, Davies RJO. American Journal of Respiratory and Critical Care Medicine. 1998;158:778-786

128) *Autonomic markers of arousal during sleep in patients undergoing investigation for OSA, their relationship to EEG arousals, respiratory events and subjective sleepiness. Pitson DJ, Stradling JR. Journal of Sleep Research 1998;7:53-60

129) *Value of beat-to-beat blood pressure changes, detected by pulse transit time, in the management of the obstructive sleep apnoea/hypopnoea syndrome. Pitson DJ, Stradling JR. European Respiratory Journal 1998;12:685-692

130) *How should we evaluate health status? A comparison of three methods in patients presenting with obstructive sleep apnoea. Jenkinson C, Stradling J, Petersen S. Quality of Life Research 1998;7:95-100

131) What is an arousal and how should it be quantified? Davies RJO, Bennett LS, Stradling JR. Sleep Reviews1998;1:87-96.

132) Oral appliances for the management of snoring and obstructive sleep apnoea.Bennett LS, Davies, Stradling JR. Thorax 1998;53:S58-S64

133) Sleep apnoea: clinical importance and facilities for investigation and treatment in the UK. Gibson GJ, Douglas NJ, Stradling JR, London DR, Semple SJG. J Royal Coll Phys Lond 1998;32:540-544

1999134) *Variation in the arousal pattern due to obstructive events in obstructive sleep apnoea.

Stradling JR, Pitson DJ, Bennett L, Barbour C, Davies RJO. American Journal of Respiratory and Critical Care Medicine. 1999;159:130-136

135) Investigation of sleep-related breathing disorders. Stradling JR. Chapter in Pulmonary Function Testing: Clinical Applications, eds Hughes and Pride, 1999.

136) Management of sleep apnoea. Bates G, Stradling JR, Davies R. Chapter for Oxford Textbook of Surgery; 1999.

137) *Second by second patterns in cortical electroencephalograph and systolic blood pressure during Cheyne Stokes breathing. Davies RJ, Bennett LS, Barbour C, Tarassenko L, Roberts SJ, Stradling JR. European Journal of Respiratory Medicine 1999;14:940-945

138) *Randomised controlled trial of therapeutic versus sub-therapeutic nCPAP in the treatment of OSA. Jenkinson C, Davies RJO, Mullins R, Stradling JR. Lancet 1999;353:2100-5

139) *Quality of life in obstructive sleep apnea: relationship with sleep fragmentation and daytime sleepiness, and the effects of nCPAP treatment. Benett L, Barbour C, Langford B, Stradling J, Davies R. American Journal of Respiratory and Critical Care Medicine. 1999;159;1884-1890.

2000140) Epidemiology of snoring and sleep apnoea in children. Ali N, Stradling JR. In Sleep and Breathing

in Pediatrics (editor Loughlin G), Lung Biology in Health and Disease series, Marcell Dekker 2000.141) *An evaluation of two methods of scoring the patient generated index in longitudinal studies.

Jenkinson C, Ruta D, Petersen S, Mowatt A, Stradling J. Medical Care 2000; in press.142) *Efficacy and safety of a novel Beclomethasone Dipropionate dry powder inhaler (Clickhaler) for

the treatment of adult asthma. Stradling JR, Pearson MG, Morice AH, Peake MD, Barnes NC. J Asthma 2000;37:183-90.

143) Snoring. Stradling JR. In Oxford Companion to the Body, ed Colin Blakemore: Oxford University Press 2000;37:183-190

144) *Steering simulation performance in patients with obstructive sleep apnoea (OSA) and matched control subjects. Juniper M, Hack MA, George CF, Davies RJO, Stradling JR. European Respiratory Journal 2000;15:590-5

145) *Is more NCPAP better? Stradling JR, Davies RJO. Sleep 2000;23:suppl 4, 150-153146) *Randomised prospective parallel trial of therapeutic versus sub-therapeutic nasal continuous

positive airway pressure on simulated steering performance in patients with obstructive sleep apnoea. Hack M, Davies RJO, Mullins R, Choi SJ, Ramdassingh-Dow S, Jenkinson C, Stradling JR.Thorax 2000;55:224-231

147) *Which aspects of breathing during sleep influence the overnight fall of blood pressure in a community population? Stradling JR, Barbour C, Glennon J, Langford BA, Crosby JH. Thorax 2000;55:393-398.

148) Efficacy of nasal CPAP in the treatment of OSAS is proven. Stradling JR, Davies RJO. American J Resp Crit Care Med 2000;161:1775-8

149) *Which derivative from overnight oximetry best predicts symptomatic response to nCPAP in patients with OSA? Choi S, Bennett LS, Mullins R, Davies RJO, Stradling JR. Respir Med 2000;94(9):895-9

150) *Case control study of 24-hour ambulatory blood pressure in patients with obstructive sleep apnoea

and normal matched control subjects. Davies CWH, Crosby JH, Mullins RL, Barbour C, Davies RJO, Stradling JR. Thorax 2000;55;736-740

151) *Prevalence of sleepiness and its relation to autonomic evidence of arousals and increased inspiratory effort in a community based population of men and women. Stradling JR, Barbour C, Glennon J, Langford BA, Crosby JH. Journal Sleep Research 2000;9:381-388

152) Sleep apnoea and driving. Pepperell J, Stradling JR, Davies RJO. Respiratory Disease in Practice 2000;16:18-21

2001153) *Is (re)titration of nasal continuous positive airway pressure (nCPAP) for obstructive sleep apnoea

(OSA) necessary? Choi S, Mullins R, Crosby JH, Davies RJO, Stradling JR. Sleep Medicine 2001;2:431-435

154) *Long term benefits in self reported health status of nasal continuous positive airway pressure therapy for obstructive sleep apnoea. Jenkinson C, Davies RJ, Mullins R, Stradling JR.QJM 2001;94:95-99

155) *Case control study of cerebrovascular damage defined by magnetic resonance imaging in patients with obstructive sleep apnoea and normal matched control subjects. Davies CWH, Crosby JH, Mullins RL, Traill ZC, Anslow P, Davies RJO, Stradling JR. Sleep 2001; 24:715-720

156) *Comparison of the effects of sleep deprivation, alcohol and obstructive sleep apnoea (OSA) on simulated steering performance. Hack MA, Choi SJ, Vijayapalan P, Davies RJO, Stradling JR. Respiratory Medicine 2001;95:594-601

157) Sleep apnoea and hypertension, proof at last? Stradling JR, Pepperell JCT, Davies RJO. Thorax 2001;56(Suppl 2):ii45-ii49.

2002 158) Cardiovascular complications of sleep apnoea. Stradling JR and Davies RJO. In Breathing

Disorders During Sleep (eds McNicholas and Phillipson): Harcourt Brace 2002, 194-208.159) Simplified diagnostic tests for obstructive sleep apnoea and its variants. Stradling JR, Davies R.

Chapter 16 in Pathogenesis, Diagnosis and Treatment of Seep Apnoea (editor Pack A), Lung Biology in Health and Disease series, Marcell Dekker 2002, 457-94.

160) Sleep studies for sleep apnoea. Pepperell JCT, Davies RJO, Stradling JR. Physiological Measurement 2002; 23:R39-74

161) *In patients on nasal continuous positive airway pressure, can mandibular advancement devices be a satisfactory substitute in the short term? Smith DM, Stradling JR. Thorax 2002;57:305-308.

162) *Evidence for the persistence of upper airway narrowing during sleep, twelve years after adeno-tonsillectomy. Tasker C, Crosby JH, Stradling JR. Arch Dis Child 2002;86:34-37

163) Systemic hypertension and obstructive sleep apnoea. Pepperell JCT, Davies RJO, Stradling JR. Sleep Medicine Reviews 2002;6:157-74

164) *Ambulatory blood pressure following therapeutic and sub-therapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised prospective parallel trial. Pepperell JC, Ramdassingh-Dow S, Crosthwaite N, Mullins R, Jenkinson C, Stradling JR, Davies RJ. Lancet 2002;359:204-10

2003 165) *Effect of Ondansetron on moderate obstructive sleep apnea, a single night, placebo-controlled trial.

Stradling JR, Smith D, Radulovacki M, Carley D. J Sleep Res 2003;12:169-170166) *Endocrine effects of nasal continuous positive airway pressure (NCPAP) in patients with

obstructive sleep apnea, a randomised controlled trial. Meston N, Davies RJO, Mullins R, Jenkinson C, Wass JAH, Stradling JR. J Int Med 2003; 254:447-454

167) *Reduction in excessive daytime sleepiness by Modafinil in patients with myotonic dystrophy. Talbot K, Stradling JR, Crosby J, Hilton-Jones D. Neuromuscular Disorders 2003;13:357-364

168) *A Randomised Prospective Parallel Trial of Adaptive Servo Ventilation versus a Sub-therapeutic Control for Cheyne Stokes Breathing in Chronic Heart Failure. Pepperell JCT, Maskell NA, Langford BA, Stradling JR, Davies RJO, AJRCCM 2003;168:1109-14

169) *Caffeine levels following treatment of obstructive sleep apnoea. Robinson GV, Pepperell JC, Davies RJO, Stradling JR. Thorax. 2003;58:801-2

170) Blood Pressure and Obstructive Sleep Apnoea. Pepperell JCT, Stradling JR, Davies RJO. Resp Dis in Pract 2003;19:16-19

2004172) Obstructive sleep apnoea and its effect on the pulmonary circulation. Stradling JR. Chapter for ‘The

Pulmonary Circulation’, edited by Dr A Peacock (2nd edition), 2004.173) Post mortem diagnosis of fatal obstructive sleep apnoea. Robinson GV, Stradling JR, Davies RJO,

Roberts ISD. Histopathology 2004;45:1-2174) *A novel, simplified approach to starting nasal CPAP therapy in OSA. Stradling JR, Hardinge M,

Smith DM. Respiratory Medicine 2004;98:155-158175) Obstructive Sleep Apnoea and hypertension. Robinson G, Davies RJO and Stradling JR. Thorax

2004;59:1089-1094176) Obstructive Sleep Apnoea, definitions, epidemiology and natural history. Stradling JR and Davies

RJO. Thorax 2004;59:73-78177) *Relative accuracy of algorithm-based prescription of nasal CPAP in OSA. Stradling JR, Hardinge

M, Paxton J, Smith DM. Respiratory Medicine 2004;98:152-154178) Sleep Apnoea does not cause cardiovascular disease. Stradling JR. American Journal of Respiratory

and Critical Care Medicine. 2004;169:148-149179) *Circulating cardiovascular risk factors in obstructive sleep apnoea: data from randomised controlled

trials. Robinson GV, Pepperell JCT, Segal HC, Davies RJO, Stradling JR. Thorax 2004;59:777-782180) Reducing the Cost of Treating Obstructive Sleep Apnea, Good News for Patients. Stradling JR.

American Journal of Respiratory and Critical Care Medicine. 2004;170:1143-42005181) Oxford Handbook of Respiratory Medicine. Chapman S, Robinson G, Stradling J, West S.

Handbook series for OUP. 2005, reprinted 2006. Highly Commended by The Society of Authors and RSM Book Awards 2006.

182) *Platelet function (measured by Platelet Function Analyser-100) and obstructive sleep apnoea. West S, Harrison P, Stradling JR. Journal Sleep Research 2005;14:325-7

183) Pulse oximetry in primary care. Menzies SM, Stradling JR. Update 2005; 15th December.2006184) *A comparison of three ways to start nasal continuous positive airways pressure treatment for

Obstructive Sleep Apnoea. West S, Jones D, Stradling JR. Thorax 2006; 61: 226-231185) *Exhaled nitric oxide as a screening tool for asthma in school children. Prasad A, Langford B,

Stradling JR, Ho LP. Respir Med. 2006;100:167-73.186) *CPAP does not reduce blood pressure in non-sleepy hypertensive OSA patients GV Robinson, DM

Smith, BA Langford, RJO Davies, JR Stradling. ERJ 2006; 27: 1-7187) Sleep apnoea, and overview. West SD and Stradling JR. In Encyclopaedia of Respiratory Medicine

(Eds. Laurent and Shapiro) Elsevier Ltd 2006.188) *Prevalence of Obstructive Sleep Apnoea in men with type 2 diabetes. West SD, Nicoll DJ, and JR

Stradling JR. Thorax 2006;61:945-50189) *Temazepam at high altitude reduces periodic breathing without impairing next-day performance: a

randomised cross-over double blind study. Nickol AH, Leverment J, Richards P, Seal P, Harris GA, Cleland J, Dubowitz G, Collier D, Milledge J, Stradling JR, Morrell MJ. J Sleep Res 2006;15:445-54

190) *Brain natriuretic peptide is unchanged after 4 weeks of continuous positive airway pressure therapy. Pepperell J, Stradling J, Davies R. J Sleep Res 2006;15:463-4

2007191) *The effect of CPAP on insulin resistance and HbA1c in obstructive sleep apnoea and type 2

diabetes. West SD, Nicoll DJ, Wallace TM, Matthews DR, Stradling JR. Thorax 2007;62:969-974192) Obstructive Sleep Apnoea. Craig S, Stradling JR. BMJ learning 2007.193) Sleep Apnoea and high risk patients. Invited BMJ editorial. Stradling JR. 2007;335:313-314194) *Post CPAP sleepiness – a specific syndrome? Stradling JR, Smith D, Crosby J. J Sleep Res

2007;16:436-438195) The role of the nose in the pathogenesis of obstructive sleep apnoea and snoring. Kohler M, Bloch

KE and Stradling JR. Eur Respir J 2007; 30: 1208–12152008196) *CPAP and measures of cardiovascular risk in males with OSAS. Kohler M, Pepperell J, Craig S, Casadei

B, Crosthwaite N, Davies RJO, Stradling JR. ERJ 2008;32:1488-96197) Obstructive Sleep Apnoea. Definition, Pathophysiology and Epidemiology. Chapter for Respiratory

Textbook. Stradling JR, Kohler M. 2008.198) Blood gas interpretation. Chapter for Respiratory Textbook. Stradling JR. 2008.

199) *Predictors of blood pressure fall with CPAP treatment of OSA. Robinson GV, Langford BA, Smith DM, Stradling JR. Thorax 2008;63:855-9

200) Driving and Obstructive Sleep Apnoea. Stradling JR. Requested editorial for Thorax 2008;63:481-3201) *Cost effectiveness and cost-utility using continuous positive airway pressure in the treatment of

severe obstructive sleep apnoea/hypopnoea syndrome in the UK. Guest JF, Helter MT, Morga A, Stradling JR. Thorax 2008;63:860-5

202) *Effects of continuous positive airway pressure on quality of life in patients with moderate to severe obstructive sleep apnea: data from a randomized controlled trial. Siccoli MM, Pepperell JC, Kohler M, Craig SE, Davies RJ, Stradling JR. Sleep 2008;31:1551-8

203) *Endothelial function and arterial stiffness in patients with minimally symptomatic obstructive sleep apnea. Kohler M, Craig S, Nicoll D, Leeson P, Davies RJO, Stradling JR. AJRCCM 2008;178:984-8

204) The use of CPAP in sleep apnoea. Smith D, Stradling J. Brit J Primary Care Nurse 2008;3:32-352009205) The role of the nose in the pathogenesis of obstructive sleep apnea. Kohler M, Bloch K, Stradling

JR. Current Opinion in Otolaryngology and Head & Neck Surgery 2009;17:33-7206) The Road Ahead to Respiratory Health – Experts Chart Future Research Directions. Heffner JE,

Holgate ST, Chung KF, Niederman MS, Daley CL, Jett JR, Stradling JR, Wells A, Light RW, Tapson VF, Hansell DM, Provonost PJ, Lee YCG. Respirology 2009;14:625-36

207) *Continuous positive airway pressure and liver enzymes in obstructive sleep apnea: data from a randomized controlled trial. Kohler M, Pepperell JCT, Davies RJO, Stradling JR. Respiration 2009; 2009;78:141-6

208) *An Economic Analysis of Continuous Positive Airway Pressure (CPAP) for the Treatment of Obstructive Sleep Apnoea-Hypopnoea Syndrome (OSAHS). Ms Helen Weatherly, Centre for Health Economics, University of York, UK. Griffin S, Mc Daid C, Durée K, Davies RJO, Stradling JR, Westwood M, Sculpher M. Int J Technology Assessment Health Care 2009;25:26-43

209) *Circulating cell-derived microparticles in patients with minimally symptomatic obstructive sleep apnoea. Ayers L, Ferry B, Craig S, Nicoll D, Stradling JR, Kohler M. ERJ 2009;33:574-80

210) *The Prevalence of Obstructive Sleep Apnea and its Association with Aortic Dilatation in Marfan’s Syndrome. Kohler M, Blair E, Risby P, Nickol AH, Wordsworth P, Forfar C, Stradling JR. Thorax 2009;64:162-6

211) *The effect of continuous positive airway pressure treatment on physical activity in patients with obstructive sleep apnea: a randomized controlled trial. West et al. Sleep Med. 2009;10:1056-8

212) Oxford Handbook of Respiratory Medicine. 2nd edition 2009. Chapman S, Robinson G, Stradling J, West S. Handbook series for OUP. 1st edition, 2005, reprinted 2006. 1st edition Highly Commended by The Society of Authors and RSM Book Awards, 2006 and 2nd edition Highly Commended in the Internal Medicine category of the 2010 BMA Medical Book Awards.

213) *Effects of continuous positive airway pressure on systemic inflammation in patients with moderate to severe obstructive sleep apnoea: a randomised controlled trial. Kohler M, Ayers L, Pepperell JCT, Packwood KL, Ferry B, Crosthwaite N, Craig S, Siccoli MM, Davies RJO, Stradling JR. Thorax 2009;64:67-73

214) *A systematic review of continuous positive airway pressure for obstructive sleep apnoea-hypopnoea syndrome. McDaid C, Durée KH, Griffin SC, Weatherly HL, Stradling JR, Davies RJO, Sculpher MJ, Westwood ME. Sleep Med Rev. 2009;13:427-436

215) *Cost-effectiveness of Oral Appliances in the treatment of Obstructive Sleep Apnea-Hypopnea. Sadatsafavi M, Marra CA, Ayas NT, Stradling J, Fleetham J. Sleep and Breathing 2009;13(3):241-52

216) Snoring and the role of the GDP: British Society of Dental Sleep Medicine (BSDSM) pre-treatment screening protocol. Stradling J, Dookun R. British Dental Journal 2009;206:307-312

217) *Continuous positive airway pressure treatment for obstructive sleep apnoea reduces resting heart rate: a randomised controlled trial. Craig et al. J Sleep Res 2009;18:329-336

218) Obstructive Sleep Apnoea in Adults. West SD, McBeath HA, Stradling JR. BMJ 2009;338:1165-62010222) *The prevalence of retinopathy in men with type 2 diabetes and obstructive sleep apnoea. West SD,

Groves DC, Lipinski HJ, Nicoll DJ, Mason RH, Scanlon PH, Stradling JR. Diabetic Medicine 2010; 27:423-30

223) Respiratory Case Histories. Nickol A, Davies H, Rahman N, Stanton A, Stradling JR. Series for OUP. 2010.

224) *Augmentation index and central aortic blood pressure in patients with abdominal aortic aneurysm. Ruegg Gion, Mason RH, Hardinge M, Perkins J, Husmann M, Russi E, Bloch K, Stradling JR, Kohler M. J Hypertens. 2010;28:2252-2257

225) *Predictors of long-term compliance with continuous positive airway pressure. Kohler M, Smith D, Tippett V, Stradling JR. Thorax. 2010;65:829-32.

226) Mechanisms of vascular damage in obstructive sleep apnea. Kohler M, Stradling JR. Nature Reviews in Cardiology. 2010;7:677-85

227) Diabetes in obstructive sleep apnoea. Kohler M, West S, Stradling JR. Am J Respir Crit Care Med. 2010;182:286-7

2011228) CPAP therapy: results of randomised controlled trials. SD West, JR Stradling. Chapter, in Sleep Apnea:

Pathogenesis, diagnosis and treatment (Editor: Allan Pack). Nov 2011. 229) *Obstructive sleep apnoea in patients with abdominal aortic aneurysms: highly prevalent and

associated with rapid expansion. Mason RH, Ruegg G, Perkins J, Hardinge M, Amann-Vesti B, Stradling JR and Kohler M. Am J Respir Crit Care Med. 2011;183:668-74

230) *The effect of simulated obstructive apnea and hypopnea on aortic diameter and blood pressure. Stoewhas A, Namdar M, Biaggi P, Russi E, Bloch K, Stradling J, Kohler M. Chest. 2011;140:675-80.

231) Pitfalls of clinical trials on pharmacological treatment for obstructive sleep apnoea – future directions. Kohler M, Stradling JR. Expert Opinion on Investigational Drugs 2011;20:1033-7

232) The role of the dentist in sleep disorders. Stradling J, Dookiun R. Dent Update 2011;38:136233) *The effects of CPAP therapy withdrawal in patients with obstructive sleep apnea: a randomised

controlled trial. Kohler M, Stoewhas A, Ayers L, Senn O, Bloch K, Russi M, Stradling J. Amer J Resp Crit Care Med. 2011;184:1192-9

2012234) *Visual improvement post CPAP therapy in subjects with diabetic clinically significant macular

oedema (CSMO) and obstructive sleep apnoea (OSA): proof of principle study. Mason R, Kirre CA, Groves DC, Lipinski HJ, Jaycock A, Winter BC, Smith L, Bolton A, Rahman N, Swaminathan R, Chong VN, Stradling JR. Respiration 2012;84:275-82

235) *Continuous positive airway pressure (CPAP) improves sleepiness but not vascular risk in patients with minimally symptomatic obstructive sleep apnoea (OSA); the MOSAIC randomised controlled trial. Craig S, Kohler,M, Nicoll D, Bratton DJ, Nunn A, Davies RJO, Stradling JR. Thorax. 2012;67:1090-6

236) *The effects of continuous positive airway pressure therapy withdrawal on cardiac repolarisation: data from a randomised controlled trial. Rossi VA, Stoewhas A-C, Camen G, Steffel J, Bloch KE, Stradling JR, Kohler M. European Heart Journal. 2012;33:2206-12

237) *Snoring and severity of symptomatic and asymptomatic carotid stenosis: a population-based study. Mason RH, Mehta Z, Fonseca AC, Stradling JR, Rothwell PM. Sleep 2012;35:1147-51

238) *High prevalence of sleep disordered breathing in patients with diabetic macular edemaMason RH, West SD, Kiire CA, Groves DC, Lipinski HJ, Jaycock A, Chong V, Stradling JR. Retina 2012;32:1791-8

239) *Atherosclerosis and arterial stiffness in obstructive sleep apnea - a cardiovascular magnetic resonance study. Kylintireas I, Craig S, Nethononda R, Kohler M, Francis J, Choudhury R, Stradling

J, Neubauer S. Atherosclerosis 2012;222:483-9240) Cross Talk proposal: most of the cardiovascular consequences of OSA are due to increased

sympathetic activity. Kohler M, Stradling JR. J Physiol 2012;590:2813-5241) Protocol for diaphragm pacing in patients with respiratory muscle weakness due to motor neurone

disease (DIPALS): a randomised controlled trial. McDermott CJ et al. BMC neurology 2012;12:742013242) *Effects of Obstructive Sleep Apnoea on Heart Rhythm. Rossi V, Stradling J, Kohler M. Eur Resp J

2013; in press (Dec 2012 epub)243) *CPAP improves endothelial function in minimally symptomatic OSA patients: results from a subset

study of the MOSAIC trial. Kohler M, Craig S, Pepperel l JCT, Nicoll D, Bratton D, Leeson P, Stradling JR. Chest 2013; in press

244) *The effects of Provent ™ on moderate-to-severe obstructive sleep apnoea during continuous positive airway pressure therapy withdrawal: a randomised controlled trial. Rossi VA, Winter B, Rahman NM,Yu L-M, Fallon J, Clarenbach CF, Bloch KE, Stradling JR, Kohler M. Thorax 2013; in press

245) Effect of CPAP on stroke risk-factors and stroke. Kohler M and Stradling JR. In Sleep, Stroke and Cardiovascular Disease. Ed Culebras A. Cambridge University Press, 2013.

246) *Leukoaraiosis on MRI in patients with minimally symptomatic obstructive sleep apnoea. Schulz UG, Mason RH, Craig, SE, Howard S, Nicoll DJ, Kohler M, Rothwell PM, Stradling J. Cerebrovascular Disease. 2013;35:363-9

247) *The effects of simulated obstructive sleep apnea and hypopnea on arrhythmic potential in healthy subjects. Carmen G, Clarenbach CF, Stowhas A-C, Rossi VA, Sievi NA, Stradling JR, Kohler M. Eur J Appl Physiol 2013;113:489-96

248) *Elevated levels of endothelial cell-derived microparticles following short term withdrawal of continuous positive airway pressure in patients with obstructive sleep apnea: data from a randomised controlled trial. Ayers L, Stoewhas AC, Ferry B, Stradling J, Kohler M. Respiration 2013;85:486-492

249) *The impact of obstructive sleep apnea on aortic disease in Marfan’s syndrome. Kohler M., Pitcher A., Blair E., Risby P., Senn O., Forfar C., Wordsworth P., Stradling J.R. Respiration 2013; in press (epub Sep 2012)

250) *Elevated levels of endothelial cell-derived microparticles following short-term withdrawal of CPAP in patients with OSA: data from a randomised controlled trial. Ayers L, Stoewhas A-C, Ferry B, Stradling J, Kohler M. Respiration 2013; in press (epub Nov 2012)

251) The Effect of Simulated Obstructive Hypopnea and Apnea on Thoracic Aortic Wall Transmural Pressures. Clarenbach C, Camen G, Sievi N, Wyss C, Stradling J, Kohler M. J Appl Physiol 2013; in press

252) Effect of continuous positive airway pressure on blood pressure in patients with minimally symptomatic obstructive sleep apnoea: a meta-analysis using individual patient data from four randomised controlled trials. Bratton DJ, Stradling JR, Barbe F, Kohler M. BMJ 2013 nearly submitted

253) Effects of CPAP treatment for OSA on visual processing of degraded words. Proudlove K, Manuel A, Hall R, Rieu R, Villarroel M, Stradling J. Respiration 2013;in press.

RESEARCH AND SLEEP CLINIC STAFF.

Current*Dr Maxine Hardinge, part time consultantDr Annabel Nickol, consultant*Debbie Nicoll, research nurse (PhD)Debby Smith, senior nurse*Ari Manuel, research registrarBarbara Winter, research nurseSally Payne, nurseBeverley Langford, nurseLyn Davies, hon. medical engineerRose Wakeford, assistant technical officerAmanda Cooper, assistant technical officer

Past medical staff (registrar and above)*Dr A Warley, research fellowDr G Chadwick, research fellow*Dr R Davies, Wellcome Junior Research Fellow and Senior RegistrarGill Thomas, research sister*Dr Nabeel Ali, research fellowAnne Sharpley, technician (part-time)*Maxine Hardinge, research registrar*Dr Lesley Bennett, research fellowJoanna Partlet, research sister, part time*Dr Melissa Hack, research fellowGlynn Rees, asthma research charge nurse/networks managerDr Claire Tasker, clinical assistant*Dr Justin Pepperell, research registrar*Dr Grace Robinson, research registrar*Dr Sophie West, research registrarDr Malcolm Kohler, research registrarDr Max Massimiliano, research registrar*Dr Sonya Craig, research registrar*Dr Rebecca Mason, research registrar

*Supervisor or co-supervisor of their PhD/MD

Visiting Staff to the sleep unit (>1 month and excluding medical/other students)Dr P Vos (Nijmegen, Netherlands, 3 months)Dr J Fleetham (Vancouver, Canada, 6 months)Dr F Fontes (San Salvador, Brazil, 1 year)Dr K Vardi-Visy (Budapest, Hungary, 2 years)Dr Hercules Tsangaris (Athens, 2½ months)Dr S Twaddell (Australia, 2½ months)Dr Soo Jeon Choi (Korea, 1 year)Professor Fleetham (2nd sabbatical, 1 year)Dr Leslie Olsen (Australia, 6 months)Dr Biliana Pencic (Serbia, 1 month)Mr David Jones (New Zealand, 1 year)Dr Jorge Avila (Argentina, several 2 month visits)Dr Malcolm Kohler (Zurich, 2 years)Dr Massimiliano Siccoli (Zurich, 1 year)

RESEARCH GRANTS

Edith Walsh grant for research into Cardio-respiratory medicine (BMA), £1000, for 1983.

MRC travelling fellowship for 1984, awarded November 1983. For a year's study in Toronto with Professor Phillipson on the control of respiratory muscles during the different phases of sleep. Oxford Regional Health Authority 'Off Service' year award for 1984. NHS locally organised research scheme. Funding for an ear lobe oximeter for studies on the prevalence and cause of nocturnal hypoxaemia in chronic neuromuscular disorders, £5000, 1984. Wellcome Senior Research Fellow from November 1985. With project grant, £250,000 over 5 years. Project grant (Wellcome Trust) for investigations into sleep disorders in children. August 1987. £25,000 over 2 years.

Extension of above grant for two further years until November 1991. £34,000. British Lung Foundation Research Fellowship for Dr. N. Ali until August 1991. £43,000.

British Lung Foundation equipment grant July 1989. £3,500.

Extension of Wellcome Senior Research Fellowship (3 yrs) with project grant, to 1994, £75,000.

Wellcome grant for one year’s salary for a research officer, Jan 1992

Oxford University A+B award for research, February 1992, 5 years in the first instance, renewed for another 5

Private medical charity, RM10 multiparameter recorder, £3000.

Wellcome grant for new analysis of the waking EEG in sleep deprivation, 2 years to March 1995, £50,000.

Devilbiss research award for 2 RM50 sleep recorders, £15,000, 1995.

British Lung Foundation grant for work on a new ambulatory technique for the diagnosis of sleep apnoea, £41,000. 2 years, August 1993-5.

Wellcome grant for a study on the "epidemiology of daytime sleepiness due to increases in upper airways resistance during sleep", £64450 over 3 years to December 1998

Wellcome Grant (with Dr R Davies) for a study on autonomic and neural net (EEG) analysis of sleep disturbance and its consequences, £70000 over 3½ years to January 1999.

Local Trust Funds research awards, ventilator for sleep studies, £7000, 1996.

Anglia and Oxford Regional Health Authority (with Crispin Jenkinson) for a randomised parallel controlled double blind trial of CPAP versus placebo in the treatment of sleep apnoea, £40,000 over 2 years to December 1998.Extension to continue with steering performance as outcome measure (£12,000), to December 1999.

British Lung Foundation grant for investigating the effects of OSA on driving, £34,000, 1½ years to December 1999.

Local Trust Funds research awards. £9350. Lacuna infarct prevalence in OSA and controls, 2000.

Local Trust Funds research awards. £5000. BNP levels in patients with heart failure, effect of CPAP.

Resmed grant to look at control of Cheyne Stokes respiration (with Dr Davies), $100,000 over 2 years to July 2001.

Cephalon Research grant, £40,000, sleepiness in myotonic dystrophy, 2 years to September 2002.

Local Trust Funds research awards (jointly with Dr Davies), fellowship for Dr Grace Robinson. £60,000, 2002.

Oxford Radcliffe Trust Funds, donations of £300,000+ for various sleep related research projects (1998 onwards).

British Heart Foundation Grant, blood pressure response to nCPAP in OSA, £36,000 to March 2004.

Research Grant from charitable arm of the Masons. Prevalence of OSA in males with diabetes, £35,000 awarded 2003.

Joint award (Dr Davies) from Cephalon for studies on fMRI in sleepiness and effect of Modafinil, £80,000, 2003.

Diabetes UK, £120,000, association between diabetes and OSA, 2 years, 2004-2006

British Heart Foundation, £174,000. Long term consequences of Sleep Apnoea, 2005-2008

Oxford Health services research committee, £60,000. Fellowship for Dr Sonia Craig to join the MOSAIC project 2006-2007

Cephalon UK, £55,000. Unrestricted research grant, long term consequences of Sleep Apnoea 2005

Resmed UK, £96,000. Cost of CPAP machines for BHF study into long term consequences of Sleep Apnoea 2005-2008

Oxford Health Services research committee, £5663 and £7000 to purchase software and equipment for flow mediated dilation measurements, and pulse wave analysis equipment, as part of the MOSAIC project 2006

Oxford Health Services research committee, £7000 to pay for measurements of inflammatory markers in stored blood samples, 2007.

ResMed UK, £15,000 towards MOSAIC study 2008

Oxford Hospitals Service Charity, £3,700 for study of Cheyne Stokes in a heart failure population (with Dr Bhattacharya)

ResMed International, £30,000 towards a study on retinopathy in patients with OSA and diabetes.

British Heart Foundation, £28,000 for further work relating to MOSAIC study, 2009

Oxford Health Services Research committee, £30,000 further extension to fellowship for Dr Sonia Craig

* Health Technology Assessment, collaboration with Mary Morrell (Brompton) and others, PREDICT, 2009-13, £1,300,000

Oxford Health services research committee, £44,000. Fellowship for Dr Rebecca Mason to work on OSA and diabetic retinopathy/AAA 2009-20010

ResMed Foundation $75,000 for a study on retinopathy in patients with OSA and diabetes 2009-2010

*OHSRC/NOHF fellowship for Dr Ari Manuel. Causes of ventilatory failure in Obese subjects. £76,000 2011-12Continued with BRC funding 2012-2014

*Resmed Foundation $760,000 with Sophie West for RCT of CPAP for diabetic retinopathy in OSA. 2012-1015

*BHF Project Grant no. PG/12/80/29891 Oxidative stress and obstructive sleep apnoea; effect of withdrawing continuous positive airway pressure therapy. £60,594 2013-2014

* currently active grants

RESEARCH RELATED ACTIVITIES

My main areas of research have been sleep and breathing disorders. As a consequence of 30 years in this area I have built up a national and international reputation. I am regularly asked to talk both at national and international meetings, contribute chapters to international textbooks, and write reviews for mainstream journals. For example in 1996 I was asked to talk at the American Thoracic Society, Lyon, Nassau and University of Virginia (I also had to turn down two other requests), in 1997 I was asked to talk at two international meetings in London and Edinburgh, and in 1998 I talked in Hong Kong, Chicago, Brazil, Argentina and Grenoble. In 1999 I was invited to talk at the American Thoracic Society (San Diego), American Society of Professional Sleep Societies (keynote speaker, Orlando), International ENT society (Cambridge) and European Respiratory Society (Madrid). Over 2000 and 2001 I was invited to talk at international meetings in Sydney, Vancouver, Florence Switzerland, Bordeaux, San Francisco and Bologna, with other invitations to Toronto, Melbourne Seattle and Las Vegas that I was unable to accept. In addition there were many national meetings (both in the respiratory and ENT world) to which I have been invited to contribute. In 2002 I was an invited speaker at international meetings in Atlanta, Zurich, Iceland, and was an RCP college lecture in Belfast. In 2003 I was invited to speak in the UK, Denmark and Finland and have had to turn down other such invites in the US. I again talked on the RCP advanced Medicine course for 2003. I have been invited to talk at international conferences in 2004, 2005 and 2006 but have turned most down due to work commitments. I did a meet the professor session and chaired at the American Thoracic Society meeting in May 2006. I was asked top do three presentations at the ATS in 2007 and two at the ATS in 2008. Also asked to give presentations to the Irish sleep society and Medical College of Sri Lankar in 2008. Invited presentations to the ATS 2009, and visiting professor University of Sydney 2009. Invited presentations at ATS, 2010, 2011, 2012, 2013.

WORKING PARTIES/CONSULTANCIES I was extensively involved with an EEC-directed working group on standardisation of investigative techniques for sleep disorders. This required eight meetings in Europe during 1990-1992 and I took on the responsibility to report on the pulmonology aspects of investigating sleep disorders. This involved assembling 14 European experts for four 2-day meetings and writing a report on current practices and future recommendations, published in December 1992. This has also led to cooperative research with a Dutch group on vastly improved ways to analyse the EEG. With four other members of the British Thoracic Society (and at the request of council) we prepared a submission document outlining the case for funding of sleep and breathing disorders by the NHS. I also sat on a Royal College of Physicians working party on Obstructive Sleep Apnoea, that reported October 1993 and re-reported on in 1997. I also took part in a consensus group in Sweden on cardiovascular consequences of sleep apnoea, publishing August 1993. I was also involved with two American Thoracic Society expert working groups in 1998. I sat on a committee for the DOH on specialist respiratory services (2001/2). I am on the committee of the Scottish Intercollegiate Guidelines Network looking at the management of sleep apnoea in adults (2000-03). I am part of the BTS peer review process, visiting other centres to provide feedback. I am on the BTS working party for sleep apnoea and responsible for designing training courses for staff entering the field, and latterly the sleep advisory group for the BTS. I have been involved with NICE on a CPAP appraisal, the 16 week wait pathway for sleep, and the RCP map of medicine project. I have been involved in several recent initiatives related to drowsy drivers, one parliamentary with Meg Munn MP. Since 2013 I have been a consultant to ResMed UK.

COURSES One week course on Management in the NHS at the King's Fund Centre, September 1989. Twelve day (spread out) management course for consultants in management at Templeton College, Oxford, 1992. “Educating consultants”. Two day course on improving educating techniques for junior staff and students. GCP for research trials 2009

REVIEWING I was a sub editor for Journal of Sleep Research (7 years). I served 3 year stints as sub editor for three other journals, Clinical Science, Physiological Measurement and Journal of Ambulatory Monitoring. I regularly review for Thorax, American Journal of Respiratory and Critical Care Medicine, and European Journal of Respiratory Medicine: occasional reviewer for BMJ, Lancet, Respiratory Medicine, Sleep, and Int J Obesity. I also review for the NHS R&D Coordinating Centre for Health Technology Assessment, Wellcome Trust.

COURSES/CONFERENCES ORGANISED1986; two day course on sleep and breathing disorders.1991; three day annual conference of the British Sleep Society1993; one day conference on sleep apnoea for British Association for Lung Research.1993; one day course on setting up a sleep clinic for the British Thoracic Society, repeated November 1993. 1993, 4, 5, 6, 7, 8, 9, 2000, 1, 2, 3, 4, 5, 6, 7, 9, 10, 11, 12, 13; annual conference for patients with OSA1996, 99, 02, 05, 08, 11 & 14; three day Worcester College conference on developments in sleep apnoea and hypoventilation

2006, 07, 08, 11; Two day conference for technicians/nurses/doctors on running a sleep service2010, 11, 12, 13, 14; One or two day symposia on sleep apnoea with Zurich University

NHS RESPONSIBILITIESPart time (from 2013) NHS consultant, Oxford Centre for Respiratory Medicine, Churchill hospital, Oxford Radcliffe Trust. 6 bed sleep laboratory, 34 studies/wk, 30 new patients/wk, 12-16 patients a week onto CPAP, >8000 patients on CPAP.Previous clinical director for the Sleep Unit for 28 years, previous director of chest unit for 10 years.Previous member of contract negotiation group, now on new technology advisory group and medical devices group.Previous member of Oxford priorities forum, representing the ORH and the new technology advisory group.Previous equipment manager for Medicine Centre. To 2011.Co-opted member of Hospital Trust Funds committee.Chairman of Oxford Health Services Research Committee for last 10 years. Now ordinary committee member.

AWARDSHospital doctor of the year award 2002BTS Silver Jubilee Award – Innovation in providing sleep services 2007Ludwig Engel Visiting Professor, University of Sydney, 2009ARTP award for services to respiratory medicine, 2010Swiss Society for Pneumonology, 2011, best overall prize for a spoken presentation (MOSAIC trial), and best overall prize for a poster (CPAP withdrawal protocol).American Academy of Sleep Medicine. 2012, Annual ‘William C. Dement Academic Achievement Award’, for members of the sleep field who have displayed exceptional initiative and progress in areas of academic research.