1

Ahmed A. Heikal

Department of Chemistry and Biochemistry Office: SSB 253C

Swenson College of Science and Engineering Office Phone: (218) 726-7036

University of Minnesota Duluth Fax: (218) 726-7394

1039 University Drive E-mail: aaheikal@d.umn.edu

Duluth, MN 55812-3011 Lab: http://www.d.umn.edu/chemistry/research/Heikal-Lab/

EDUCATION

California Institute of Technology* Applied Physics Ph.D. 1995

Tanta University, Tanta, Egypt Physics MS 1986

Tanta University, Tanta, Egypt Physics BS 1980

* Thesis Title: “Ultrafast Molecular Dynamics in Complexed Trans-Stilbene”

Thesis Advisor: Professor Ahmed Zewail (Nobel Laureate in Chemistry, 1999)

ACADEMIC POSITIONS

2012-Present Professor, Department of Chemistry and Biochemistry, University of Minnesota

Duluth, Duluth, MN

2009-2012 Associate Professor, Department of Chemistry and Biochemistry, University of

Minnesota Duluth, Duluth, MN

2003-2009 Associate Professor, Department of Bioengineering, Pennsylvania State

University, State College, PA

2000-2003 Research Associate, School of Applied & Engineering Physics, Cornell

University, Ithaca, NY.

1997-2000 Postdoctoral Associate, School of Applied & Engineering Physics, Cornell

University, Ithaca, NY.

1995-1997 Research Fellow, Department of Chemistry, California Institute of Technology /

Jet Propulsion Laboratory, Pasadena, CA.

1988-1995 Graduate Research Assistant, Department of Chemistry, California Institute of

Technology, Pasadena, CA.

PROFESSIONAL AFFILIATIONS

– The American Chemical Society (ACS), 1996 - present

– Biophysical Society, 1997 - present

– The American Society of Biochemistry & Molecular Biology (ASBMB), 2009 - present

– The American Society for Cell Biology (ASCB), 2003 – 2010

– Biomedical Engineering Society (BMES), 2006 - 2010

– The Optical Society of America (OSA), 1997 - 2010

– The International Society for Optical Engineering (SPIE), 2000 - 2010

– The American Physical Society (APS), 2003 - 2004

INVITED REVIEW

[1] Heikal, A.A. Intracellular coenzymes as natural biomarkers for metabolic activities and

mitochondrial anomalies. Biomarkers in Medicine, 4(2): 241-263 (2010).

2

INVITED BOOK CHAPTERS

[1] Heikal, A.A. “A Multiparametric Fluorescence Approach for Biomembrane Studies.” In,

“Advances in Planar Lipid Bilayers and Liposomes”, Editor: Iglic A, Volume 13,

Elsevier, Inc.; p. 169-197 (May 2011).

[2] Heikal, A.A. “A Multiparametric Imaging of Cellular Coenzymes for Monitoring Metabolic

and Mitochondrial Activities.” In, “Reviews in Fluorescence 2010”, Editor: Chris D.

Geddes, Springer Science + Business Media, LLC, DOI 10.1007/978-1-4419-9828-6_10

(2012).

PEER-REVIEW PUBLICATIONS

[1] Solntsev P.V., K.L. Spurgin, J.R. Sabin, A.A. Heikal, V.N. Nemykin. 2012. Photoinduced

charge transfer in short-distance ferrocenylsubphthalocyanine dyads. Inorg. Chem.,

51(12):6537-6547.

[2] Yu, Q. and A.A. Heikal. Two-photon autofluorescence dynamics imaging reveals sensitivity

of intracellular NADH concentration and conformation to cell physiology at the single-

cell level. Journal of Photochemistry and Photobiology (B): Biology, 95: 46–57 (2009);

Press Release.

[3] Ariola, F.S., Z. Li, C. Cornejo, R. Bittman, and A.A. Heikal. Membrane fluidity and lipid

order in ternary giant unilamellar vesicles using a new Bodipy-cholesterol derivative.

Biophysical Journal, April Issue, 96(7), 2696–2708 (2009).

[4] Yu, Q., M. Proia, and A.A. Heikal. Integrated biophotonics approach for noninvasive and

multiscale studies of biomolecular and cellular biophysics. J. Biomed. Optics;

July/August Issue, 13(4):0413151-14, (2008).

[5] Larson, D.R., H. Ow, H.D. Vishwasrao, A.A. Heikal, U. Wiesner, and W.W. Webb. Silica

nanoparticle architecture determines radiative properties of encapsulated fluorophores.

Chem. Mater., 20:2677-2684 (2008).

[6] Davey, A.M., K. Krise. E.D. Sheets, and A.A. Heikal. Molecular perspective of antigen-

mediated mast cell signaling. J. Biol. Chem., 283:7117-7127 (2008); Press Release.

[7] Davey, A.M., R.P. Walvick, Y. Liu, A.A. Heikal, and E.D. Sheets. Membrane order and

molecular dynamics associated with IgE receptor crosslinking in mast cells. Biophys. J.,

92:343-355 (2007).

[8] Ariola, F.S., D.J. Mudaliar, R.P. Walvick, and A.A. Heikal. Dynamics imaging of lipid

phases and lipid-marker interactions in model biomembranes. Phys. Chem. Chem. Phys.,

8:4517-4529 (2006).

[9] Liu, Y., H.-R. Kim, and A.A. Heikal. Structural basis of fluorescence fluctuation dynamics

of green fluorescent proteins in acidic environments. J. Phys. Chem. B, 110:24138-24146

(2006).

[10] Shi, K., A.A. Heikal, and Z. Liu. A single-shot approach for measuring two-photon action

cross-section of fluorescent markers. Optics Express, 14:8722-8727 (2006).

[11] Korlach, J., D.W. Baird, A.A. Heikal, K.R. Gee, G.R. Hoffman, and W.W. Webb.

Spontaneous nucleotide exchange in low molecular weight GTPases by fluorescently

3

labeled -phosphate-linked GTP analogs. Proc. Natl. Acad. Sci. USA, 101:2800-2805

(2004).

[12] Vishwasrao, H.D., A.A. Heikal, K.A. Kasischke, and W.W. Webb. Conformational

dependence of intracellular NADH on metabolic state revealed by associated

fluorescence anisotropy. J. Biol. Chem., 280:25119-25126 (2005); Press Release, Issue

Cover and Paper of the Week.

[13] Hess, S.T., A.A. Heikal, and W.W. Webb. Fluorescence photoconversion kinetics in novel

green fluorescent protein pH sensors (pHluorins). J. Phys. Chem. B, 108:10138-10148

(2004); Issue Cover.

[14] Hess, S.T., E.D. Sheets, A. Wagenknecht-Wiesner, and A.A. Heikal. Quantitative analysis

of the fluorescence properties of intrinsically fluorescent proteins in living cells. Biophys.

J., 85:2566-2580 (2003).

[15] Huang, S., A.A. Heikal, and W.W. Webb. Two-photon fluorescence spectroscopy and

microscopy on NAD(P)H and flavoprotein, Biophys. J., 82:2811-2825 (2002).

[16] Hess, S.T., S. Huang, A.A. Heikal, and W.W. Webb. Biological and chemical applications

of fluorescence correlation spectroscopy: a review. Biochem. 41:697-705 (2002).

[17] Heikal, A.A., S.T. Hess, and W.W. Webb. Multiphoton spectroscopy and excited state

dynamics of enhanced green fluorescent protein (EGFP): acid-base specificity. Chem.

Phys., 274:37-55 (2001).

[18] Kuebler, S.M., M. Rumi, T. Watanabe, K. Braun, B.H. Cumpston, A.A. Heikal, L.L.

Erskine, S. Thayumanavan, S. Barlow, S.R. Marder, J.W. Perry. Optimizing two-photon

initiators and exposure conditions for three-dimensional lithographic microfabrication. J.

Photopoly. Sci. Tech., 14(4):657-668 (2001).

[19] Rumi, M., J.E. Ehrlich, A.A. Heikal, J.W. Perry, S. Barlow, Z. Hu, D. McCord-Maughon,

T.C. Parker, H. Roeckel, S. Thayumanavan, S.R. Marder, D. Beljonne, and J.-L. Bredas.

Structure-property relationships for two-photon absorbing chromophores: bis-donor

diphenylpolyene and bis(styryl)benzene derivatives. J. Am. Chem. Soc., 122(39):9500-

9510 (2000).

[20] Heikal, A.A., S.T. Hess, G.S. Baird, R.Y. Tsien, and W.W. Webb. Molecular spectroscopy

and dynamics of intrinsically fluorescent proteins: coral red (dsRed) and yellow (Citrine).

Proc. Natl. Acad. Sci. USA, 97:11996-12001 (2000).

[21] Schwille, P., S. Kummer, A.A. Heikal, W.E. Moerner, and W.W. Webb. Fluorescence

correlation spectroscopy reveals fast optical excitation-driven intramolecular dynamics of

yellow fluorescent proteins. Proc. Natl. Acad. Sci. USA, 97:151-156 (2000).

[22] Cumpston, B.H., S.P. Ananthavel, S. Barlow, D.L. Dyer, J.E. Ehrlich, L.L. Erskine, A.A.

Heikal, S.M. Kuebler, I.-Y.S. Lee, D. McCord-Maughon, J. Qin, H. Rockel, M. Rumi,

X.-L. Wu, S.R. Marder, and J.W. Perry. Two-photon polymerization initiators for three-

dimensional optical data storage and microfabrication. Nature, 398:51-54 (1999).

[23] Albota, M., D. Beljonne, J.-L. Bredas, J.E. Ehrlich, J-Y. Fu, A.A. Heikal, S.T. Hess, T.

Kogej, M.D. Levin, S.R. Marder, D. McCord-Maughon, J.W. Perry, H. Rockel, M. Rumi,

4

G. Subramaniam, W.W. Webb, X.-L. Wu, and C. Xu. Design of organic molecules with

large two-photon absorption cross sections. Science, 281:1653-1656 (1998).

[24] Heikal, A.A., J.S. Baskin, L. Banares, and A.H. Zewail. Structural effects on the

isomerization dynamics of trans-stilbenes: IVR, microcanonical reaction rates, and the

nature of the transition state. J. Phys. Chem. A, 101:572-590 (1997).

[25] Heikal, A.A., S.H. Chong, J.S. Baskin, and A.H. Zewail. Microscopic friction and solvation

in barrier crossing: isomerization of stilbene in size-selected hexane clusters. Chem. Phys.

Lett., 242:380-389 (1995).

[26] Kim, S.K., J.J. Breen, D.M. Willberg, L.W. Peng, A.A. Heikal, J.A. Syage, and A.H.

Zewail. Solvation ultrafast dynamics of reactions. 8. Acid-base reactions in finite-sized

clusters of naphthol in ammonia, water, and piperidine. J. Phys. Chem., 99:7421-7435

(1995).

[27] Lienau, C., A.A. Heikal, and A.H. Zewail. Picosecond dynamics of hexane-solvated trans-

stilbene. Chem. Phys., 175:171-191 (1993).

[28] Banares, L., A.A. Heikal, and A.H. Zewail. Ultrafast dynamics of isomerization reactions:

structural effects in stilbene(s). J. Phys. Chem., 96:4127-4130 (1992).

[29] Heikal, A.A., L. Banares, D.H. Semmes, and A.H. Zewail. Real-time dynamics of

vibrational predissociation in anthracene-argonn (n = 1, 2, 3). Chem. Phys., 156:231-250

(1991).

[30] Breen, J.J., L.W. Peng, D.M. Willberg, A. Heikal, P. Cong, and A.H. Zewail. Real-time

probing of reactions in clusters. J. Chem. Phys., 92:805-807 (1990).

PAPERS PUBLISHED IN BOOKS BASED ON CONFERENCE PROCEEDINGS

[1] Liu, Y. F.S. Ariola, H.-R. Kim, Q. Yu, R. Walvick, and A.A. Heikal. Two-photon excited-

state and conformation dynamics of NADH binding with dehydrogenases. Femtochemistry

and Femtobiology, VII, William Castlemann (Editor), Elsevier B.V. Ltd. 396-401 (2006).

[2] Walvick, R.P., D.J. Mudaliar, and A.A. Heikal. Quantitative analysis of biomolecular

concentration in living cells with high spatial resolution. Institute of Electrical and

Electronics Engineers (IEEE), pp 37 (2005).

[3] Cumpston, B.H., S.P. Ananthavel, S. Barlow, D.L. Dyer, J.E. Ehrlich, L.L. Erskine, A.A.

Heikal, S.M. Kuebler, I.-Y.S. Lee, D. McCord-Maughon, J. Qin, H. Rockel, M. Rumi, X.-L.

Wu, S.R. Marder, and J.W. Perry. Two-photon polymerization initiators for three-

dimensional optical data storage and microfabrication. Multiphoton Excitation Microscopy,

Editors: B.J. Thompson, SPIE Optical Engineering Press, 175:212-215 (2003).

[4] Albota, M., D. Beljonne, J.-L. Bredas, J.E. Ehrlich, J.-Y. Fu, A.A. Heikal, S.E. Hess, T.

Kogej, M.D. Levin, S.R. Marder, D. McCord-Maughon, J.W. Perry, H. Rocket, M. Rumi, G.

Subramaniam, W.W. Webb, X.-L. Wu, and C. Xu. Design of organic molecules with large

two-photon absorption cross sections. Multiphoton Excitation Microscopy, Editors: B.J.

Thompson, SPIE Optical Engineering Press, 175:507-510 (2003).

[5] Heikal, A.A., S.T. Hess, E.D. Sheets, and W.W. Webb. Mutation-photophysics relationship

in intrinsically fluorescent proteins. Femtochemistry and Femtobiology: Ultrafast Dynamics

5

in Molecular Science, Editors: A. Douhal and J. Santamaria, World Scientific, Singapore, pp

774-781 (2002).

[6] Heikal, A.A. and W.W. Webb. Multiphoton fluorescence microscopy for functional imaging

of biomolecules. Nonlinear Optics: Materials, Fundamentals and Applications (NLO), Bio-

Chemical Nonlinear Optics (ThA4-1): 321-323 (2002).

INVITED TALKS

Heikal, A.A. Single-molecule studies of Bodipy-FTY720, an immune suppressor, in cultured

C3H10T1/2 cells. The 9th Annual Advanced Imaging Techniques Workshop, University

of California-Berkeley, Berkeley, CA, January 18-20, 2012.

Heikal, A.A. Associated anisotropy of cellular NAD(P)H for quantitative biochemistry in living

cells: Experiment versus simulation. The Fifth Annual Exploration of Advanced TCSPC

Techniques, Bethesda, MD, November 10-11, 2011.

Heikal, A.A. Specialized lipid domains and IgE receptor signaling. Department of Physics,

University of Minnesota, Minneapolis, MN, October 25, 2011.

Heikal, A.A. Snapshots of specialized lipid domains in model and functional biomembranes.

Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE, March 30, 2011.

Heikal, A.A. Specialized lipid domains: From model systems to functional biomembranes.

Department of Chemistry, Gustavus Adolphus College, St. Peter, MN, March 11, 2011.

Heikal, A.A. Cellular autofluorescence: Opportunities and challenges. 8th Advanced Imaging

Methods, University of California Berkeley, Berkeley, CA, January 19 - 21, 2011.

Heikal, A.A. Multiparameteric micro-spectroscopy of genetically GFP-encoded MHC I during

antigen processing in fibroblast cells. 4th

Boston Workshop on Advanced TCSPC

Techniques, Boston, MA, October 11 - 12, 2010.

Heikal, A.A. Intracellular coenzymes as natural biomarkers for metabolic and mitochondrial

activities, Advanced Imaging Methods in Cell Biology and Neuroscience Symposium,

Creighton University, Omaha, Nebraska, April 30, 2010.

Heikal, A.A. Single-molecule studies of MHC class I proteins in fibroblast cells, Symposium: 5th

Making Single Molecule Fluorescence Lifetime Measurements Simple, Brookhaven

National Laboratory, April 26-28, 2010.

Heikal, A.A. Intracellular coenzymes as natural biomarkers for metabolism and mitochondrial

anomalies, Department of Biology, UMD, Duluth, MN, March 5th

, 2010.

Heikal, A.A. Fluorescence dynamics perspective of MHC class I proteins in fibroblast cells,

Department of Chemistry, University of North Dakota – Grand Forks, ND, February 05,

2010.

Heikal, A.A. Single-molecule diffusion and conformation studies of MHC class I proteins in

fibroblast cells, Department of Physics, North Dakota State University – Fargo, ND,

February 04, 2010.

Heikal, A.A. Fluorescence dynamics imaging of MHC class I proteins in mouse fibroblast cells,

7th

Advanced Imaging Methods – Berkeley, CA, January 20-22, 2010.

Heikal, A.A. MHC class I proteins in mouse fibroblast cells: a fluorescence dynamics

perspective, Department of Chemistry and Biochemistry, University of Minnesota –

Duluth, November 13, 2009.

6

Heikal, A.A. Structural heterogeneity of GFP-tagged, major histocompatibility complex class I

protein in mouse fibroblast cells. 3rd Boston Workshop on Advanced TCSPC Techniques,

Boston, MA, October 15 - 17, 2009.

Heikal, A.A. Examining cell pathophysiology using intracellular coenzymes: A nonlinear micro-

spectroscopy approach. Department of Physics, College of Pharmacy, University of

Minnesota, Duluth, MN, November 25, 2008.

Heikal, A.A. Cellular Autofluorescence: Towards quantitative biochemistry of energy

metabolism and redox state of living cells. Biophysics Colloquium, Cornell University,

Ithaca, NY, November 5, 2008.

Heikal, A.A. Molecular dynamics perspective of membrane domains: From model systems to

IgE receptor signaling in RBL Cells. Developmental Resource for Biophysical Imaging

Opto-Electronics, School of Applied and Engineering Physics, Cornell University, Ithaca,

NY, November 5, 2008.

Heikal, A.A. Molecular dynamics perspective of membrane domains: from model systems to

IgE receptor signaling in RBL mast cells. University of Pennsylvania, Department of

Chemistry, Philadelphia, PA, October 16, 2008.

Heikal, A.A. Cellular autofluorescence: towards quantitative biochemistry of energy metabolism

and redox state of living cells. 2nd

Boston Workshop on Advanced TCSPC Techniques,

Boston, MA, September 22-23, 2008.

Heikal, A.A. Fluorescence dynamics perspective of membrane domains: from model systems to

IgE receptor signaling in RBL mast cells. 2nd

Boston Workshop on Advanced TCSPC

Techniques, Boston, MA, September 22-23, 2008.

Heikal, A.A. Fluorescence dynamics Imaging of lipid domains in synthetic and natural

membranes. Department of Chemistry, Center for Biophysics and Computational

Biology, University of Illinois at Urbana-Champaign, Urbana, IL, September 3, 2008.

Heikal, A.A. Fluorescence dynamics imaging of biomembranes: IgE receptor signaling in RBL

cells. Department of Chemistry and Biochemistry, Queens College, CUNY, Flushing,

NY, May 5, 2008.

Heikal, A.A. Fluorescence dynamics imaging of biomembranes: IgE receptor signaling in RBL

cells. Department of Chemistry, Michigan State University, East Lansing, MI, March 27,

2008.

Heikal, A.A. Fluorescence dynamics imaging of biomembranes: IgE receptor signaling in RBL

cells. Department of Molecular Physiology & Biological Physics, University of Virginia,

Charlottesville, VA, March 24, 2008.

Heikal, A.A. Cellular autofluorescence: towards quantitative biochemistry and cell pathology.

Department of Biological Engineering, Massachusetts Institute of Technology,

Cambridge, MA, February 18, 2008.

Heikal, A.A. Intermolecular interactions in biomembranes: from engineered mimics to living

cells. Center of Optical Technology, Lehigh University, Bethlehem, PA, October 8, 2007.

Heikal, A.A. Short-range dynamics imaging of lipid phases in synthetic and natural

biomembranes. The American Chemical Society National Meeting, San Francisco, CA,

September 11, 2006.

7

Heikal, A.A. Navigating cellular biocomplexity with molecular sensitivity: energy metabolism.

Center of Optical Technology, Lehigh University, Bethlehem, PA, September 28, 2006.

Heikal, A.A. Quantitative analysis of energy metabolism using intrinsic coenzymes. Department

of Physics, University of Maine, Orono, ME, November 11, 2005.

Heikal, A.A. Quantitative analysis of energy metabolism using intrinsic biomolecules.

Department of Physics, University of Maine, Orono, ME, November 11, 2005.

Heikal, A.A. Nanoscale functional imaging of mitochondria in living cells. Department of

Biology, Pennsylvania State University, University Park, PA, April 26, 2005.

Heikal, A.A. Monitoring metabolic activities in living cells using native biomolecules.

Department of Biochemistry and Molecular Biology, Pennsylvania State University,

University Park, PA, April 4, 2005.

Heikal, A.A. Fluorescence characterization of internally labeled DNA with fluorescently tagged

nucleotides. Biocomplexity IV: Regenerative Biology and Medicine, Indiana University,

Bloomington, IN, May 17, 2003.

Heikal, A.A. Multiphoton fluorescence snapshots of energy metabolism and protein dynamics.

Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA,

February 20, 2003.

Heikal, A.A. Multiphoton fluorescence snapshots of energy metabolism and protein dynamics.

Department of Physics, Vanderbilt University, Nashville, TN, February 11, 2003.

Heikal, A.A. Multiphoton fluorescence snapshots of energy metabolism and protein dynamics.

Biomedical Group, University of Massachusetts Medical School, Worcester, MA,

January 30, 2003.

Heikal, A.A. Multiphoton fluorescence snapshots of energy metabolism and protein dynamics.

Department of Bioengineering, Pennsylvania State University, University Park, PA,

January 17, 2003.

Heikal, A.A. Multiphoton fluorescence snapshots of energy metabolism and protein dynamics.

Department of Physics, Indiana University, Bloomington, IN, December 2, 2002.

Heikal, A.A. Multiphoton fluorescence snapshots of energy metabolism and protein dynamics.

Department of Physics, The College of Optics and Photonics (CREOL), University of

Central Florida, Orlando, FL, November 7, 2002.

PAPERS (ABSTRACTS) PRESENTED AT PROFESSIONAL CONFERENCES

International:

– Wickramasinghe, D., J.Bartusek, and A.A. Heikal. 2011. “Single molecule studies of Bodipy-

FTY720 immune suppressor in biomembranes.” The 17th International Workshop on

Single Molecule Spectroscopy and Ultra Sensitive Analysis in the Life Sciences, Berlin,

Germany, September 7 – 9.

– Welty, R., J. Bentley, D. Wickramasinghe, and A.A. Heikal. 2011. “Multiscale dynamics of

single molecules in biomimetic crowding,” The 12th Conference on Methods and

Applications of Fluorescence (MAF-12), Strasbourg, France, September 11 – 14.

8

– Walvick, R.P., D.J. Mudaliar, and A.A. Heikal. 2005. Accurate estimate of biomolecular

concentration in living cells as high spatial resolution. The International Biophysics

Congress, Montpellier, France, August 26-September 1.

– Mudaliar, D.J., R.P. Walvick, and A.A. Heikal. 2005. Lipid-phase specificity of rotational

diffusion and molecular orientation in biomembranes. The International Biophysics

Congress, Montpellier, France, August 26-September 1.

– Heikal, A.A., S.T. Hess, E.D. Sheets, and W.W. Webb. 2001. Color carnival by marine life:

understanding the molecular dynamics and spectroscopy of intrinsically fluorescent

proteins. Vth

Femtochemistry Conference, Toledo, Spain, September 2.

– Hess, S.T., A.A. Heikal, and W.W. Webb. 2000. Comparative single molecule photophysics of

green fluorescent proteins: mutation effects. The 6th

International Workshop on Single

Molecule Detection and Ultrasensitive Analysis of Life Sciences, Berlin-Adlershof,

Germany, September 27.

– Heikal, A.A., P. Schwille, S.T. Hess, and W.W. Webb. 1999. pH- and excitation wavelength-

dependence of one- and two-photon fluorescence spectroscopy and dynamics of

enhanced green fluorescent protein (EGFP). 2nd

International Symposium on GFP, San

Diego, CA, May 22.

National:

– Dhanushka Wickramasinghe, Robert Bittman, and Ahmed A. Heikal. 2011. Partitioning and

single-molecule diffusion dynamics of Bodipy-FTY720 in biomembranes. 55th Annual

Biophysical Society Meeting, Baltimore, MD (March 5-9).

– Porter, J.J., R. Reed, T. Fisher, and A.A. Heikal. 2009. Molecular crowding effects on

multiscale diffusion as a function of the hydrodynamic volume of both the solute and

solvent molecules. The 53rd

Biophysical Society Meeting, Boston, MA, February 28 –

March 4.

– Ariola, F.S., and A.A. Heikal. 2009. Examining the role of lipid variations and proteins on

membrane biophysics: synthetic versus natural membrane vesicles. The 53rd

Biophysical

Society Meeting, Boston, MA, February 28 – March 4.

– Yu, Q., and A.A. Heikal. 2009. Noninvasive Approach for quantitative analysis of energy

metabolism and mitochondrial anomalies in living cells. The 53rd

Biophysical Society

Meeting, Boston, MA, February 28 – March 4.

– Sheets, E.D., and A.A. Heikal. 2009. Membrane nanodomains facilitate immunoreceptor

signaling. The Biomedical Engineering Society Annual Meeting, Pittsburgh, PA, October

7 – 10.

– Yu, Q., A.T. Lutes, and A.A. Heikal. 2008. Cellular autofluorescence: towards quantitative

biochemistry associated with cell pathology and respiratory state activities. 2008 BMES

Annual Fall Meeting, St. Louis, MO, October 2-4.

– Yu, Q., A. Lutes, and A.A. Heikal. 2008. Two-Photon autofluorescence dynamics for

quantitative cell pathology and respiratory state activities. Frontiers in Optics

(FiO)/Laser Science XXIV (LS) Conference, Rochester, NY, October 19-23.

9

– Ariola, F.S. and A.A. Heikal. 2008. Membrane fluidity and lipid order in synthetic and natural

membrane vesicles. 2008 BMES Annual Fall Meeting, St. Louis, MO, October 2-4.

– Davey, A.M., K. Krise, E.D. Sheets, and A.A. Heikal. 2008. Comparative studies of

physiological and non-physiological crosslinking of IgE receptor in RBL mast cells. 2008

BMES Annual Fall Meeting, St. Louis, MO, October 2-4.

– Yu, Q., R. Walvick, and A.A. Heikal. 2008. Fluorescence-based biochemistry on intrinsic

cofactors in human breast normal and cancerous cells. 52st Annual Biophysical Society

Meeting (Session: Oxidative Phosphorylation), Long Beach, CA, February 2-6.

– Lutes, A.T., Q. Yu and A.A. Heikal. 2008. Fluorescence dynamics and concentration imaging

of intrinsic flavin at the single cell level. 52st Annual Biophysical Society Meeting

(Session: Oxidative Phosphorylation), Long Beach, CA, February 2-6.

– Sheets, E.D., A.M. Davey, K.M. Krise, and A.A. Heikal. 2008. Imaging membrane dynamics

participating in immunoreceptor signaling. 52st Annual Biophysical Society Meeting

(Session: Motions of Cell Surface Molecules), Long Beach, CA, February 2-6.

– Davey, A.M., K.M. Krise, A.A. Heikal, and E.D. Sheets. 2008. Dynamics imaging of

membrane nanostructural changes associated with antigen-mediated IgE receptor

signaling in mast cells. 52st Annual Biophysical Society Meeting (Session: Lipids and

Signaling on Membrane Surfaces), Long Beach, CA, February 2-6.

– Davey A.M., K.M. Krise, A.A. Heikal, and E.D. Sheets. 2007. Molecular perspective of

antigen-mediated IgE receptor signaling in mast cells. 47th

Annual American Society for

Cell Biology Meeting, Washington, DC, December 1-5.

– Ariola, A.S., M. Kyoung., E.D. Sheets, M. Edidin, and A.A. Heikal. 2007. Lateral

heterogeneity and diffusion patterns of major histocompatibility complex (MHC) class I

proteins in membrane blebs. 47th

Annual American Society for Cell Biology Meeting,

Washington, DC, December 1-5.

– Heikal, A.A. 2007. Molecular dynamics perspective of cellular autofluorescence: from single-

cell to neural network in brain slices. 47th

Annual American Society for Cell Biology

Meeting, Washington, DC, December 1-5.

– Yu, Q., M. Proia, and A.A. Heikal. 2007. Integrated Biophotonics Approach for Quantitative,

Multiscale Biophysics of Biological Systems. 47th

Annual American Society for Cell

Biology Meeting, Washington, DC, December 1-5.

– Yu, Q., M. Proia, and A.A. Heikal. 2007. Integrated biophotonics approach for quantitative and

multiscale analysis of biological systems. Biomedical Engineering Society Meeting, Los

Angeles, CA, Sept. 26-30.

– Heikal, A.A. 2007. Molecular dynamics perspective of cellular autofluorescence: From a single

cell to brain slices. Biomedical Engineering Society Meeting, Los Angeles, CA, Sept. 26-

30.

– Heikal, A.A. 2007. Fluorescence dynamics imaging of IgE receptor signaling in RBL mast

cells. Biomedical Engineering Society Meeting, Los Angeles, CA, Sept. 26-30.

10

– Ariola, F.S., and A.A. Heikal. 2007. Integrative biomedical imaging of lipid analogue

interactions in engineered lipid bilayers. Biomedical Engineering Society Annual Fall

Meeting, Los Angeles, CA, Sept. 26-30.

– Proia, M.A., S.R. Arumugam, S.J. Benkovic, and A.A. Heikal. 2007. Single-molecule studies

of forked DNA binding with helicase loading protein (gp59). American Chemical Society

234th National Meeting, Boston, MA, August 19-23.

– Ariola, F.S., D.J. Mudaliar, R.P. Walvick, and A.A. Heikal. 2007. Ultrafast dynamics imaging

of lipid analogue interactions in giant unilamellar vesicles. American Chemical Society

234th

National Meeting, Boston, MA, August 19-23.

– Shi, K., A.A. Heikal, and Z. Liu. 2007. Single-shot two-photon action cross section

measurement. Conference on Lasers and Electro-Optics, Baltimore, MD, May 6 – 11.

– Davey, A.M., E.D. Sheets, and A.A. Heikal. 2007. Correlating membrane nanostructure with

IgE receptor crosslinking in mast cells: An ultrafast dynamics approach. 51st Annual

Biophysical Society Meeting, Baltimore, MD, March 3-7.

– Heetderks, J.J., F.S. Ariola, P.S. Weiss, and A.A. Heikal. 2007. Quantitative analysis of lipid-

marker and domain-domain interactions using ultrafast spectroscopy of carbocyanine

dyes in binary-phase giant unilamellar vesicles. 51st Annual Biophysical Society Meeting,

Baltimore, MD, March 3-7.

– Ariola, F.S., D.J. Mudaliar, R.P. Walvick, and A.A. Heikal. 2007. Examining lipid-marker

interactions in model membranes using ultrafast dynamics imaging. 51st Annual

Biophysical Society Meeting, 51st Annual Biophysical Society Meeting, Baltimore, MD,

March 3-7.

– Yu, Q., R.P. Walvick, F.S. Ariola, Y. Liu, and A.A. Heikal. 2007. Molecular dynamics

imaging of intrinsic NAD(P)H in breast normal and cancer cells at the single cell level.

51st Biophysics Society Meeting, Baltimore, MD, March 3-7.

– Yu, Q., M. Proia, and A.A. Heikal. 2007. Integrated biophotonics approach for non-invasive

and quantitative analysis of multiscale biological systems. 51st Biophysics Society

Meeting, Baltimore, MD, March 3-7.

– Davey, A.M., E.D. Sheets, and A.A. Heikal. 2006. Correlating membrane nanostructure with

IgE receptor crosslinking in mast cells: an ultrafast dynamics approach. The American

Society for Cell Biology, San Diego, December 9-13.

– Davey, A.M., Y. Liu, A.A. Heikal, and E.D. Sheets. 2006. Visualizing and probing molecular

order and dynamics of lipid rafts in mast cells. 232nd

ACS National Meeting, San

Francisco, CA, September 9-14.

– Yu, Q., and A.A. Heikal. 2006. Non-invasive dynamics assay of quantitative analysis of

cellular mitochondria. The Biomedical Engineering Society Meeting, Chicago, IL,

October 11-14.

– Yu, Q., V. Aravamuthan, F. Ariola, Y. Liu, and A.A. Heikal. 2006. Dynamics imaging of

intrinsic NAD(P)H in breast cancer cells as a biosensor of cellular physiology. The

Biomedical Engineering Society Meeting, Chicago, IL, October 11-14.

11

– Muthukrishnan, G., Y. Liu, A.A. Heikal, and W.O. Hancock. 2006. Single molecule

fluorescence measurements uncover differences between Kinesin-1 and Kinesin-2

motors. The Biomedical Engineering Society Meeting, Chicago, IL, October 11-14.

– Heikal, A.A. 2006. Short-range dynamics imaging of lipid phases in synthetic and natural

biomembranes. The American Chemical Society Meeting, San Francisco, CA, September

9-14; Invited Talk.

– Sheets, E.D., A.M. Davey, R.P. Walvick, and A.A. Heikal. 2006. Visualizing and probing

molecular order and dynamics of lipid rafts in mast cells. The American Chemical Society

Meeting, San Francisco, CA, September 9-14.

– Sheets, E.D., A.M. Davey, and A.A. Heikal. 2006. Visualizing and probing molecular

nanostructure in living mast cells. 38th

Middle Atlantic Regional ACS Meeting, The

Analytical Chemistry of Cellular Interactions with Biomaterial Surfaces, Hershey, PA.

June 4-7.

– Sheets, E.D., A.M. Davey, and A.A. Heikal. 2006. Correlating membrane nanostructure and

signaling activity in living mast cells using dynamics imaging. FASEB Summer Research

Conference, Molecular Biophysics of Cellular Membranes, Saxtons River, VT, July 1-6.

– Davey, A.M., Y. Liu, A.A. Heikal, and E.D. Sheets. 2006. Visualizing and probing the order

and molecular dynamics of lipid rafts in mast cells. Frontiers in Live Cell Imaging,

Bethesda, MD, April 19-21.

– Zhang, Y. D.J. Mudaliar, A.A. Heikal, and W.O. Hancock. 2006. Comparison of Kinesin-2 and

Kinesin-1 processivity and microtubule affinity. Biophysical Society Annual Meeting,

Salt Lake City, UT, February 18-22.

– Davey, A.M., K. Vats, A.A. Heikal, and E.D. Sheets. 2006. Visualizing and probing the order

and molecular dynamics of lipid rafts. Biophysical Society Annual Meeting, Salt Lake

City, UT, February 18-22.

– Mudaliar, D.J., R.P. Walvick, A.A. Heikal. 2005. Short-range dynamics of lipid domains in

model biomembranes. The American Society for Cell Biology Conference, San Francisco,

CA, December 10-14.

– Walvick, R.P. and A.A. Heikal. 2005. Quantitative analysis of energy metabolism pathways in

breast cancer cells using native NAD(P)H. The American Society for Cell Biology

Conference, San Francisco, CA, December 10-14.

– Heikal, A.A., J. Korlach, D.W. Baird, G.R. Hoffmann, K. Gee, R.A. Cerione, and W.W. Webb.

2004. Structural aspects of phosphate tagged GTP analogs for G proteins studies. 50th

Anniversary Meeting of the Gordon Conference on Isotopes in Biological and Chemical

Sciences, Ventura, CA, February 15-20.

– Heikal, A.A., H. Vishwasrao, K.A. Kasischke, and W.W. Webb. 2003. Conformational

changes of native NADH associated with neural energy metabolism in hippocampal

slices. 43rd

Meeting of the American Society for Cell Biology, San Francisco, CA, Dec

13-17.

12

– Sheets, E.D., S.T. Hess, A. Wagenknecht-Wiesner, and A.A. Heikal. 2003. Quantitative

analysis of the rotational flexibility of Lyn-B protein in living RBL mast cells. 43rd

Meeting of the American Society for Cell Biology, San Francisco, CA, Dec 13-17.

– Mudaliar, D.J., R.P. Walvick, and A.A. Heikal. 2005. Lipid-order fluctuation in model

membranes at high spatio-temporal resolution. The 49th

-Biophysical Society Meeting,

Long Beach, CA, February 12-16.

– Zhang, Y., D.J. Mudaliar, A.A. Heikal, and W.O. Hancock. 2005. Microtubule-binding affinity

and structural studies of EGFP-tagged KIF3A/B motors. The 49th

-Biophysical Society

Meeting, Long Beach, CA, February 12-16.

– Rivera, W.M., H.-R. Kim*, and A.A. Heikal. 2004. Endogenous flavin and NADH

fluorescence as a probe for energy metabolism. Annual Biomedical Research Conference

for Minority Students, Dallas, TX, November 10-13.

– Korlach, J., B. Baird, A.A. Heikal, K.R. Gee, G.R. Hoffman, and W.W. Webb. 2003.

Spontaneous nucleotide exchange of fluorescently labeled -phosphate linked GTP

analogs in low molecular weight GTPases. 43rd

Meeting of the American Society for Cell

Biology, San Francisco, CA, Dec 13-17.

– Vishwasrao, H.D., A.A. Heikal, K.A. Kasischke, and W.W. Webb. 2003. Two-photon time and

wavelength resolved spectroscopy probes conformational changes of intrinsic NADH

associated with neural energy metabolism. 33rd

Annual Meeting of Society for

Neuroscience, New Orleans, LA, November 8-12.

– Kasischke, K.A., H.D. Vishwasrao, P.J. Fisher, A.A. Heikal, W.R. Zipfel, and W.W. Webb.

2003. Two-photon NADH imaging resolves functions of astrocytes and neurons in

metabolic recovery during focal neural activity. 33rd

Annual Meeting of Society for

Neuroscience, New Orleans, LA, November 8-12.

– Heikal, A.A., H. Vishwasrao, K. Kasischke, and W.W.Webb. 2003. Metabolic activity effects

on the excited state dynamics of native NADH in brain slices. Frontiers in Optics and

Laser Sciences XIX, Tucson, AZ, October 5-9.

– Heikal, A.A., and W.W. Webb. 2002. Multiphoton fluorescence microscopy in biology. SPIE-

The International Society for Optical Engineering, Nonlinear Spectroscopy, Seattle, WA,

USA, July 08.

– Kasischke, K., H. Vishwasrao, A.A. Heikal, and W.W. Webb. 2002. Two-photon redox

fluorimetry: a new functional imaging technique for visualizing of energy metabolism in

brain tissue. The Biophysical Society Meeting, San Francisco, CA, February 23-27.

– Vishwasrao, H., A.A. Heikal, K. Kasischke, and W.W. Webb. 2002. Probing cellular redox

state with time resolved multiphoton spectroscopy. The Biophysical Society Meeting, San

Francisco, CA, February 23-27.

– Hess, S.T., A.A. Heikal, and W.W. Webb. 2002. Effects of mutations on photophysics of

intrinsically fluorescent proteins. The Biophysical Society Meeting, San Francisco, CA,

February 23-27.

13

– Heikal, A.A., S. Huang, M. Halik, S.R. Marder, W. Wenseleers, J.W. Perry, and W.W. Webb.

2002. Newly designed two-photon fluorescence markers for biological applications. The

Biophysical Society Meeting, San Francisco, CA, February 23-27.

– Hess, S.T., A.A. Heikal, and W.W. Webb. 2001. Advantageous molecular photophysical

fluorescence properties of DsRed and Citrine. The Biophysical Society Meeting, Boston,

MA, February 17-21.

– Heikal, A.A., J. Korlach, and W.W. Webb. 2001. Time-resolved fluorescence and anisotropy

of free and DNA-bound fluorescently labeled nucleotides. The Biophysical Society

Meeting, Boston, MA, February 17-21.

– Heikal, A.A., S.T. Hess, and W.W. Webb. 2000. Comparative ultrafast molecular dynamics of

selected green fluorescent proteins. American Chemical Society, 220th

PHYS-553,

Washington DC, August 21-25.

– Heikal, A.A., J. Korlach, and W.W. Webb. 2000. Time-resolved fluorescence and anisotropy

of free and DNA-bound fluorescently labeled nucleotides. American Chemical Society,

220th

PHYS-553, Washington DC, August 21-25.

– Heikal, A.A., S.T. Hess, P. Schwille, and W.W. Webb. 2000. Ultrafast molecular dynamics of

selected green fluorescent protein mutants. The Biophysical Society Meeting. New

Orleans, LA, February 12-16.

– Hess, S.T., A.A. Heikal, and W. W. Webb. 2000. Reversible light-induced proton transfer

reaction in ecliptic green fluorescent protein. The Biophysical Society Meeting, New

Orleans, LA, February 12-16.

– Huang, S., A.A. Heikal, and W.W. Webb. 2000. Multiphoton fluorescence spectroscopy of

LipDH, FAD, and NAD(P)H. The Biophysical Society Meeting, New Orleans, LA,

February 12-16.

– Huang, S., A.A. Heikal, and W.W. Webb. 2000. Multiphoton spectroscopy and microscopy of

NAD(P)H and flavin fluorescence. The American Society for Biochemistry and

Molecular Biology Meeting, New Orleans, LA, February 12-16.

Regional:

– Welty, R., J. Bentley, D. Wickramasinghe, and A.A. Heikal. 2011. "Diffusion dynamics of

single molecules confined in biomimetic crowded environment", Joint ACS Midwest

/Great Lakes Regional Meeting, St. Louis, MO, October 19-22.

– Jillian Bartusek and Ahmed A. Heikal§. 2011. Partitioning, stoichiometry, and diffusion

dynamics of FTY720 (an immune modulator) in Triton X-100 micelles. The Minnesota

Academy of Science Annual Meeting, Winchell Undergraduate Research Symposium,

Northfield, MN, April 16. “Best of Session Poster Presentation” Award. §

– Walvick, R.P. and A.A. Heikal. 2005. Quantitative analysis of biomolecular concentration in

living cells with high spatial resolution. The Institute of Electrical and Electronic

Engineers Conference, Hoboken, NJ, April 1-5.

14

– Kim, H.-R., R.P. Walvick, W.M. Rivera, Y. Liu, and A.A. Heikal. 2005. Rotational

complexity of enzyme-cofactor binding under equilibrium conditions. Femtochemistry

VII Conference, Washington, DC, July 17-22.

Heikal, A.A., S. Huang, M. Halik, S.R. Marder, W. Wenseleers, J.W. Perry, and W.W. Webb.

2001. Fluorescence spectroscopy, dynamics and imaging of designed two-photon

fluorescent markers in Triton X-100 micelles and RBL cells. Opto Northeast and

Imaging 2001: Biomedical Optics and Imaging Session, Rochester, NY, April 10.

Local:

– Alfveby, J. and A.A. Heikal. 2011. Electroformation of giant unilamellar vesicles for

intermolecular interactions studies in lipid bilayer sssemblies. SURP Poster Fair,

University of Minnesota Duluth, Duluth, MN, August 11.

– Bartusek, J., D. Wickramasinghe, and A.A. Heikal. 2011. Oxidative stress affects both

mitochondrial morphology and activities in C3H10T1/2 Cells. SURP Poster Fair,

University of Minnesota Duluth, Duluth, MN, August 11.

– Velasquez, M.S., and A.A. Heikal. 2011. Analysis of cholesterol and lipid interactions in a

Triton X-100 micelles using dual-color fluorescence cross-correlation spectroscopy.

SURP Poster Fair, University of Minnesota Duluth, Duluth, MN, August 11.

– Steltz, P., D. Wickramasinghe, and A.A. Heikal. 2010. Biophysical studies of the Golgi

apparatus and endoplasmic reticulum in living cells using single-molecule imaging.

SURP Poster Fair, University of Minnesota Duluth, Duluth, MN, August 12.

POSTDOCTORAL ASSOCIATE ADVISED

Dr. Yuexin Liu, Department of Bioengineering, Pennsylvania State University, August 2005 -

August 2006

PH.D. STUDENTS ADVISED

Qianru Yu, Ph.D. Degree, Department of Bioengineering, Pennsylvania State University, 2005 -

2009

Angel Davey, Ph.D. Degree, Department of Chemistry, Pennsylvania State University, 2002 -

2008

Florly Ariola, Ph.D. Candidate (incomplete), Department of Bioengineering, Pennsylvania State

University, 2005 - 2008

M.S. STUDENTS ADVISED

Dhanushka Wickramasinghe, M.S. Current MS degree candidate, Department of Chemistry and

Biochemistry, University of Minnesota Duluth, 2009 – present (Plan A)

Robb Welty, Department of Chemistry and Biochemistry, University of Minnesota Duluth,

Current M.S. degree candidate, 2011 - present

John Alfveby, Department of Chemistry and Biochemistry, University of Minnesota Duluth,

Current M.S. degree candidate, 2012 - present

15

Qianru Yu, M.S., Department of Bioengineering, Pennsylvania State University, 2005 - 2008

Andrew Lutes, M.S., Department of Bioengineering, Pennsylvania State University, 2006 - 2008

Deepti Mudaliar, M.S., Department of Bioengineering, Pennsylvania State University, 2003 -

2005

Ronn Walvick, M.S., Department of Bioengineering, Pennsylvania State University, 2003 - 2005

UNDERGRADUATE RESEARCH STUDENTS ADVISED

Urji Yusuf, Department of Chemistry and Biochemistry, University of Minnesota Duluth:

FA2012 - Present

Jillian Bartusek, Department of Chemistry and Biochemistry, University of Minnesota Duluth:

Chem 3194, SURP-2011, UROP (FA 2010, SP 2011, SU 2011, FA 2011)

John Alfveby, Department of Chemistry and Biochemistry, University of Minnesota Duluth:

Chem 3194, SURP-2011 (grant) (SP2011, SU 2011, FA 2011)

Monica S. Velasquez, Department of Chemistry and Biochemistry, College of St. Scholastica,

Duluth, MN, SURP-2011 (grant) (SU 2011, FA 2011)

Randi Timerman Department of Chemistry and Biochemistry, University of Minnesota Duluth:

(Chem 3194: Fall 2011 - Present)

Travis Fransen Department of Chemistry and Biochemistry, University of Minnesota Duluth:

(Chem 3194: Fall 2011 - Present)

Brett Tuominen, Department of Chemistry and Biochemistry, University of Minnesota Duluth:

Chem 3194, UROP (F2010, S2011)

Peter Steltz, Department of Chemistry and Biochemistry, University of Minnesota Duluth: Chem

3194, 2010-SURP (FA 2009, SP 2010, SU 2010)

Robb Welty, Department of Chemistry and Biochemistry, University of Minnesota Duluth:

Chem 3194 (FA 2009, SP 2010, SP 2011, SU 2011)

Jacob Bentley, Department of Chemistry and Biochemistry, University of Minnesota Duluth:

Chem 3194 (FA 2010, SP 2011, FA 2011)

Christine Cornejo, Department of Bioengineering, Schreyer Honors College, Pennsylvania State

University, University Park, PA (FA 2007, SP 2008, FA 2008, SU 2009, SP 2009)

(NSF/REU: SU 2008)

Alice Lee, Department of Bioengineering, Schreyer Honors College, Pennsylvania State

University, University Park, PA (SP 2009).

Joseph Porter, Department of Chemistry and Biochemistry, Juniata College, Huntingdon, PA

(SU 2008)

Ricardo Ayala, Department of Chemistry, University of Puert Rico, Port Rico (SU 2007 and SU

2008), Biomaterials & Bionanotechnology Summer Institute, BBSI; Pennsylvania State

University)

Chieh-Hsin Kuan, Department of Bioengineering, Pennsylvania State University, University

Park, PA (FA 2005, SP 2006, SU 2006)

16

Yamine Noza, Department of Chemistry, University of Virginia, (SU 2006), Biomaterials &

Bionanotechnology Summer Institute, BBSI; Penn State University

Hye-Ryong Kim, Department of Chemistry, University of Rochester, Rochester, NY (SU 2004,

SU 2005), Biomaterials & Bionanotechnology Summer Institute, BBSI; Pennsylvania

State University

Chandandeep Kaur, University of California Irvine, Irvine, CA ( SU 2005), Summer Research

Opportunity Program, SROP, Pennsylvania State University

Andra Colbert, McNair Scholarship, Pennsylvania State University, University Park, PA (SU

2004)

Wilnelia M. Rivera, Department of Chemistry, University of Puert Rico, Port Rico (SU 2004),

Summer Research Opportunity Program, SROP, Pennsylvania State University

Vasuda Ramachandran, Department of Electrical Engineering, Pennsylvania State University,

University Park, PA (SU 2004, FA 2004, SP 2005)

TEACHING

Courses Taught:

CHEM 5624: Advanced Physical Chemistry I (Spring; graduates), 2010 - present

IBS 5010: Biochemistry and Molecular Biology (course director, co-Instructor, Spring;

graduates), 2011 - present

PHAR 6161: Drug Delivery I (co-Instructor; Fall; professionals), 2009 - present

PHAR 6164: Biopharmaceutics (Facilitator; Fall, professionals), 2009 - present

BIOE 423: Biotrasport II: Chemical Reaction Kinetics (Spring, undergraduates), 2003 - 2009

BIOE 597C: Biophysics of Molecular Assemblies (Fall, graduates), 2007 - 2008

BIOE 520: Advanced Biophotonics in Life Sciences (Fall, graduates), 2004 – 2009

BIOE 100S: First-Year Seminar in Bioengineering (Fall, undergraduates), 2005

Physics and laboratory instructor, Department of Physics, Tanta University, Egypt (1980 - 1988)

SERVICE

National Committee Work:

– Member: NIH/Enabling Bioanalytical and Imaging Technologies (EBIT) Study Section,

San Antonio, TX (October 10-11, 2012).

– Referee: Students Travel Awards applications, The 56th Annual Meeting of the

Biophysical Society (San Diego, CA, Feb. 25-29, 2012).

– Referee for a scientific proposal submitted to the American Association for the

Advancement of Science (AAAS); entitled: “Probing the Effect of Lipid-Protein

Interactions on the Dynamics of Biological Self-assembly”; March 2011.

– Reviewer for a chapter 12 in a book, entitled “Physical Models of Biological Systems”

(Author: Philip Nelson), which will published by WH Freeman and Co; May 2011.

17

– Referee: Students Travel Awards applications, The 55th Annual Meeting of the

Biophysical Society (Baltimore, Maryland, March 5-9, 2011).

– Track Chair, Biomedical Imaging and Optics track, which consists of ten (10) sub-tracks

(sessions), of the Biomedical Engineering Society (BMES) conference (Pittsburgh,

PA, October 7-10, 2009).

– Referee: Students Travel Awards applications, The 54th Annual Meeting of the

Biophysical Society (San Francisco, CA, Feb. 20-24, 2010).

– Session Chair: “Nonlinear and Optical Coherent Tomography Imaging” at the

Biomedical Engineering Society (BMES) conference (Pittsburgh, PA, October 7-10,

2009).

– Session chair: “Tissue, Small Animal, and In Vivo Diagnostic Imaging”, Biomedical

Engineering Society (BMES), Pittsburg, PA (October 7-10, 2009). [Substituting for a

colleague who was sick]

– Session Chair: “Fluorescence Spectroscopy” at the 53rd Annual Meeting of Biophysical

Society (Boston, MA, February 28 - March 4, 2009).

– Reviewer for a book proposal, entitled “Autofluorescence: Time-Resolved Imaging of

NADH”, which was submitted to CRC Press | Chapman & Hall | Garland Science |

Routledge; November 2009.

– Poster Judge: the Student Research Achievement Award (SRAA), Membrane Biophysics

Subgroup, The 53rd

Biophysical Society Meeting, Boston, MA, March 1, 2009.

– Referee: Students Travel Awards applications, The 53rd

Biophysical Society Meeting,

Boston, MA, March 1, 2009.

– Member, Education Committee of the Biophysical Society (2008 – 2011).

– Member, Student Affairs Committee of the Biomedical Engineering Society, BMES,

(2006 – 2010).

– Member of the Review Panel for NSF SBIR/STTR proposals, Optical Biosensors/

Bioinstrumentation panel (August 2009).

– Co-leader of the Biophotonics Section in the Center of Optical Technology (NSF-funded

center, Lehigh/Penn State) (2005 – 2009).

– Member of the NIH Review Panel for P41 Research Center Proposal (site visit, 2009)

– Referee for scientific research proposal submitted for the Natural Sciences and

Engineering Research Council of Canada (2009).

– Election judge for the Bioenergetics subgroup of the Biophysical Society (2006 –

present).

– Session Chair: “Cholesterol-Dependent Lateral Heterogeneities” at ACS conference

(Physical Chemical Foundations of Biological Membrane Phenomena) (San

Francisco, CA, September 10-14, 2006).

– Session Chair: “Protein Dynamics and Photobiology” at the Femtochemistry VII

conference (Washington DC, July 17-21, 2005).

18

– Organizer and Session Chair, session on cancer research at the Penn State Cross-Over

Conference (October 2005).

– Referee for Peer-Review Scientific Journals:

Biophysical Journal (2003 – present)

Chemical Physics Letters (2003 – present)

Journal of Physical Chemistry B (2003 – present)

Journal of Photochemistry and Photobiology (2007 – present)

ACS Nano (2007 – 2009)

Physical Chemistry Chemical Physics (2008 – present)

Proceedings of the National Academy of Science, USA (2000)

The Royal Society of Chemistry Journal (2007 – present)

BioMed Central/BMC Evolutionary Biology (2009 – present)

Soft Matter, (2009 – present),

Analyst (2009 – present)

Biochimica et Biophysica Acta (2009 – present)

Journal of Current Medicinal Chemistry (2009 – present)

Nature Protocols (2009 – present)

Optics Letters (2003 – present)

Optics Review (2003 – present)

Optics Express (2004 – present)

University of Minnesota – Duluth (2009 – present):

– Co-Chair: Unit Change Team, Swenson College of Science and Engineering

– Member: Integrated Strategic Advisory Team, ISAT (2011-12)

– Moderator: Pharm.D. IV Paper Seminars, Phar 6182, Spring Semester 2010,

College of Pharmacy, University of Minnesota-Duluth, Duluth, MN, January,

2010 – present.

– Participant: Curricular Revision Retreat, College of Pharmacy, University of

Minnesota, Twin Cities, MN, January 13, 2010.

– With the help of Sue Johnson, Terry Guggenbuehl, I helped creating a weekly

seminar list to be distributed among all faculty and graduate students to enhance

seminar attendance. This UMD weekly seminar list was also posted on a

dedicated web site (http://www.d.umn.edu/ilsc/index.html).

– With the help of Dr. George Tachte, Dr. Lester Drewes, and others, I spearheaded

an effort to establish the Interdisciplinary Life Science Consortium (ILSC) in

order to enhance further the interdisciplinary research culture here at UMD.

http://www.grad.umn.edu/oii/Groups/current/IDLifeSciences.html

– Member: Graduate Teaching Assistant Microteaching Session, 2011 – present

– Member: UMD Integrated Biosciences (IBS) Graduate Program, helped with IBS 5101

(Biochemistry and Molecular Biology) as instructor (in a small part) and course

director, 2011 – present

– Facilitator: Graduate Teaching Assistants Microteaching, Session: September 01, 2011

19

– Project Judge: The NE MN Regional Science Fair, University of Minnesota Duluth,

Duluth, MN, February 5th, 2011.

– Reviewer: Undergraduate Research Opportunity Program (UROP) Proposals, University

of Minnesota Duluth, Duluth, MN, 2010 - 2011.

– Orientation Advisor: Freshman advising for incoming students, two sessions in 2011

– Participant: Graduate Students Orientation, lecturing on “Research Conduct and Ethics”,

August, 2011

– Advisor: Graduate Students Orientation, Physical Chemistry students, Department of

Chemistry and Biochemistry, UMD, 2010 - present

– Advisor: Chemistry-Biochemistry Club (CBC) Club, Department of Chemistry and

Biochemistry, UMD, Fall 2011 – Present

– Director: Committee of UMD Summer Undergraduate Research Program (SURP),

Department of Chemistry and Biochemistry, UMD, 2011 – present

– Member: Committee of UMD Summer Undergraduate Research Program (SURP),

Department of Chemistry and Biochemistry, UMD, 2009 – 2010

– Member: Graduate Admission Committee, Department of Chemistry and Biochemistry,

UMD, 2009 - Present

– Reporter: Faculty meeting minutes, Department of Chemistry and Biochemistry, UMD,

2009 – SU 2011

University of Minnesota (2009 – present):

– Member: Social Concerns Committee, Faculty Senate, (2009 – 2013)

– Member: Reviewing Panel for AHC Seed Grant Proposals, (August, 2010)

Pennsylvania State University (2003 – 2009):

Ph.D. Committees: Serving as a committee member on twenty two (22) Ph.D. students

from five departments throughout Penn State.

Bioengineering Department Service: Candidacy Exam Development Committee, Graduate

Student Admission Committee, Curriculum Committee (Chem.E. Option),

Biothermodynamics Course Development.

College of Engineering Service: Member of the reviewing committee for the Grace

Woodward Proposals (2006 – 2007). Member of the Faculty Selection Committee for

the Schreyer Honors College (2009).

University Service: Biophotonics Committee, Materials Research Institute (2006); Co-

leader for Biophotonics Thrust at the Center of Optical Technology, NSF-Supported

Training Program (Lehigh/Penn State): 2005 – 2009; Member of the Advisory Board

for the Center for Quantitative Cell Analysis, Huck Institutes of the Life Sciences:

2005 – 2009; Member of the internal reviewing committee of NSF (IGERT) pre-

proposals, College of Engineering representative (February 14, 2007); Faculty

Selection Committee, Schreyer Honors College (2009).

OUTREACH AND CIVIC ENGAGEMENT

20

(1) Ahmed A. Heikal. “Egypt at a Crossroad: A Personal Perspective of a Culture, History, and

Future”. Public Lecture, The Royal D. Alworth, Jr. Institute for International Studies,

October 05, 2011.

(2) Ahmed A. Heikal. “The America That I Know”. Op-Ed, Duluth News Tribune, Opinion,

September 06, 2011.

(3) Ahmed A. Heikal. “Protestors must reinvent a moderate, tolerant Egypt”. Op-Ed, Duluth

News Tribune, Opinion, June 29, 2011.

(4) "Project Judge" at the NE MN Regional Science Fair (February 5th, 2011), University of

Minnesota Duluth, Duluth, MN.

(5)"Project Judge" at the Lakeview Christian Academy Science Fair (January 17th, 2011),

Lakeview Christian Academy, Duluth, MN.

(6) "Project Judge" at the State Science and Engineering Fair (March 27, 2010), Minnesota

Academy of Science, Crowne Plaza Hotel, St. Paul, MN.

(7) Ahmed A. Heikal. “Let there be light: how we use lasers to learn about life, health and

diseases.” BioDays: Public Lecture. Pennsylvania State University, University Park, PA,

April 4, 2007.

(8) In collaboration with Dr. Erin Sheets and 4-H club, Dr. Heikal has created and presented a

scientific exhibit for kids at Meadville County Fair (August 23, 2005, 2006, 2007, 2008).

This science exhibit was featured in Erie Times-News, Page 7A, Wednesday, August 20,

2008.