cytotoxicity - science€¦ · leica tcs sp8 sted 3x is based on the modular platform leica tcs...
TRANSCRIPT
cytotoxicity
lid handling
apoptosis
touchscreen
GPCR
compactfootprint
cell viability
cellprotection
high definitionpipetting
epigenetics
integratedanalysis
controlledenvironment
teach-free
highproductivity
cellsignaling
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Wednesday, October 22, 201412 noon Eastern, 9 a.m. Paciˇc, 5 p.m. UK, 6 p.m. Central Europe
Register Now!webinar.sciencemag.org
Speakers
Jefrey Engelman, M.D., Ph.D.Harvard Medical SchoolBoston,MA
Michael B. Yafe, M.D., Ph.D.Massachusetts Institute ofTechnologyCambridge, MA
During the webinar, viewers will:ï Gain an understanding of the speciˇc molecules and pathways that are the
targets for rationally designed therapies
ï Learn about efforts to overcome resistance to the ˇrst FDA-approved therapy
targeting a hyperactive kinase
ï Review mechanisms by which tumor cells resist inhibitors that target cell
survival and growth pathways
ï Hear how the rewiring of cell death pathways can sensitize cells to traditional
chemotherapy agents
ï Have their questions answered live by the expert panel.
This webinar is the ˇrst in a series focusing on the pathways that allow for cancerdevelopment and progression, the emerging research in identifying and target-ing these pathways, and the innovations in the development of cancer treatmentoptions. Recent advances in our understanding of cancer have revealed thatthe disease cannot be understood through simple analysis of genetic mutationswithin cancerous cells. Instead, tumors should be considered complex tissuesin which the cancer cells evolve and communicate with the surrounding cellularmicroenvironment to promote their own survival and dissemination. Althoughtherapies against speciˇc signaling proteins or pathways have been remarkablysuccessful at treating certain cancers, the tumors frequently develop resistance,leading to even more aggressive forms of the disease.
This webinar will focus on how rewiring of signaling pathways in response todrug treatment contributes to resistance and how this knowledge can be lever-aged to develop more effective treatment strategies.
Michael W. Deininger, M.D., Ph.D.University of UtahSalt Lake City, UT
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1638 26 SEPTEMBER 2014 • VOL 345 ISSUE 6204 sciencemag.org/products SCIENCE
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