d bp is sensitive to da kinetics for illustration, consider da spikes of constant area
DESCRIPTION
D BP is Sensitive to DA Kinetics For illustration, Consider DA spikes of Constant Area. DA Conc. (nM). DA Conc (nM). D BP. D BP varies with timing of the DA response. (the impulse response is time-varying). Yoder, Wang, & Morris (2004) J Nuc Med, 45(5) 903-911. raclopride. DA. - PowerPoint PPT PresentationTRANSCRIPT
1 Yoder, Wang, & Morris (2004) J Nuc Med, 45(5) 903-911.
BP is Sensitive to DA Kinetics
For illustration, Consider DA spikes of Constant Area
DA
Co
nc
. (n
M)
BP varies with timing of the DA response.(the impulse response is time-varying)
DA
Co
nc
(nM
)
BP
2
Did we discover this?
Endres CJ, Carson RE. (1998) Assessment of dynamic neurotransmitter changes with bolus or infusion delivery of neuroreceptor ligands. J Cereb Blood Flow Metab 18:1196-1210
they said…
0
d0
dt
K
)t(DA1
k
'Bk
dt)t(F
)t(F
BP
11
BP1
BPV
DA
off
maxon
RAC
RAC
11
1
(1)
DAraclopride
3
0
0
)(1
'
)(
)(11
1
max
11
1
dt
KtDA
kBk
dttF
tF
BPBP
BPV
DA
off
on
RAC
RAC
d
The free tracer is the “shutter” of the “dopamine-camera”
Free
11C-raclopride
FRAC(t)
The picture (BP) is “weighted” by the scenes when the shutter is open widest.
DA
time
Free
dopamine, DA(t)