Dandruff Formation

Hygeaphos A.S. in Action

Scalp flaking, itching & redness

Increased:- pro-inflammatory fatty acids- inflammatory cytokines (IL-8)

Lipase of Malassezia furfur decomposes sebum

Reduced oils

Reduction of skin barrier (K10)

Restores skin barrier (K10)

Hygeaphos A.S.

Dandruff and flaking

Reduced:- pro-inflammatory fatty acids- inflammatory cytokines (IL-8)

Reduced DHT

Controls itch and redness

Controls dandruff and flaking

Itching and redness

Testosterone activated by 5 alpha-reductase produces DHT (dihydrotestosterone).Elevated levels of DHT result in increased sebum production.

DHT(dihydrotestosterone)

IL-8(interleukin 8)-25% -32%

400x

400x

Control

Treated with Hygeaphos A.S.48 hour incubation period

Increased production of K-10 (Keratin 10)

EffectivenessIn vitro testing - keratinocytes

Ex vivo testingSkin fragments -- immunofluorescence

Scalp oilSebumeter®-20% Dandruff

Corneofix®-61.3%

Instrumental analysis

• 2 groups; 33 volunteer test subjects; men & women aged 18 to 65

• Hygeaphos A.S. vs. zinc pyrithione

• Equivalent results and statisitics

No dandruff / mild dandruff

98.9%

No erythema

96.9%

No oily scalp

84.4%

No itch / mild itch

84.4%

Clinical evaluation - dermatologist

Test subject responses

No dandruff / mild dandruff93.8%

No dandruff / mild dandruff noticeable on clothing

90.6%

No itch / mild itch90.7% No erythema87.5%

Softer hair34.4% Would purchase product93.8%

In vivo testing

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INNOVATIVE dandruff FIGHTING

Xylitol (and) Sodium Phosphate (and) Water

INCI Name

• Water-soluble

• Emulsions: add during last phase of production (up to 45°C) dissolved in water (1:3)

• Aqueous systems (shampoos, tonics, spray deodorants): dissolve during aqueous phase or make an aqueous solution (1:3) and add during final phase of production

• Proper pH use: 6.0 – 7.0

Formulation Guide

3%

Effective Usage Level

Anti-dandruff shampoos and hair treatments

Application

• Reduces scalp flaking, itching and redness

• Reduces excess scalp oils

• Restores and improves skin barrier

Benefits

Sodium Laureth Sulfate 27%

Cocamidopropyl Betaine 30%

Sensactive C-30

21.50

14.00

2.35

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Phase AWater q.s.to 100.00

Uniquat-7 0.50

Chemysoap S 3R 0.30

Phase BGlycerin 3.00

Phase CWater 10.00

Hygeaphos A.S. 3.00

Phase DCitric acid q.s pH = 6.0 – 7.0

Phase EPreservative q.s.

Phase FLauryl Glucoside 2.00

PEG-120 Methyl Glucose Dioleate 0.10

Suggested Formulation

Manufacturing Process

Anti-dandruff shampoo

1. Heat and stir the components of phase A until

complete melting of Chemysoap S 3R.

2. Add the components of phase B in the indicated

order. Stir.

3. Add the previously prepared phase C. Stir.

4. Add phase D for pH adjustment.

5. Add phase E. Stir.

6. Add phase F for viscosity adjustment. Stir.

Clear formulation

Blends easily

(% p/p)