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Daniel Jensen Moore, M.D., Ph.D. Business Address: 2200 Children’s Way 11136 DOT Nashville, TN 37232 Business Phone: 615-322-7427 Fax: 615-343-5845 E-mail: daniel.moore@vanderbilt.edu Date of Birth: January 13, 1974 Personal Data: Home Address: 508 Trace Creek Dr Nashville, TN, 37221 Home Phone: 615-948-6721 Marital Status: Married (wife: Paige; Children: Julia (2006) and Alexander (2011)) Education and Postgraduate Training: Harvard University 1992-1996 AB, summa cum laude in Biochemical Sciences University of Pennsylvania 1996-2004 Ph.D. May, 2003 Dissertation Advisor: Ali Naji, M.D., Ph.D. Title: Aberrant T Cell Activation in the NOD Mouse: A Critical Role for APCs in Autoimmune Disease M.D. May, 2004 Vanderbilt University/Vanderbilt Children’s Hospital Pediatric Intern 2004-2005 Pediatric Resident 2005-2007 Fellow (Clinical and Research), Pediatric Endocrinology 2007-2010 Fellow (Research), Microbiology and Immunology 2008-2010 (Mentor: Jacek Hawiger, MD, PhD)

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Academic Positions: Instructor in Pediatrics, Vanderbilt University 2010-2012 Assistant Professor of Pediatrics, Vanderbilt 2012-pres Assistant Professor of Pathology, Microbiology, and Immunology 2012-pres Licensure and Certifications: TN #43186 Diplomate of the American Board of Pediatrics 10/28/2008-pres American Board of Pediatrics, Pediatric Endocrinology 11/17/2011-pres Professional Memberships: Lawson Wilkins Pediatric Endocrine Society Education Council Endocrine Society Endocrine Fellows Foundation (past member) American Academy of Pediatrics, Fellow Newman Society Society for Clinical and Translational Science Society for Biomedical Diabetes Research American Society of Transplantation American Association of Immunologists (member 00230425) Cell Transplant Society International Xenotransplantation Association International Islet and Pancreas Transplant Association Society for Pediatric Research Professional Activities: University Service (Vanderbilt)

Institutional Review Board, ad-hoc committee member 2005-pres Pediatric Residency Applicant Interviewer 2006-pres TrialNet Advisory Board, 2007-pres Webmaster, Pediatric Endocrinology and Diabetes 2007-pres Pediatric Endocrinology Fellowship Selection Committee 2008-pres House Staff Advisory Council, 2009-2010 VAPR Faculty Advisory Council, 2015-pres

Other Service TrialNet Industry Relations Committee (international) 2014-pres Teaching and Mentoring Experience: Harvard University

After School Science Instructor, K-3, Cambridge Public Schools, Fall 1994 Teaching Fellow, Chem E1, Professor James Davis, Fall 1994

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Award Peer Tutor, 1994-1996 University of Pennsylvania

Graduate Associate, Spruce College House 1998-2002 Teaching Assistant Bio 404, Professor Mike Cancro Fall1999-Spring 2000 Teaching Assistant Bio 221, Instructor Jean Scholz, Fall 2000 Chemistry Mentoring Coordinator, Spring 2001-2002 Director, Penn Mentoring Program, June 2002-June 2003 Academic Tutor, Spruce College House, June 2002-June 2003 Instructor, Biology 45: Readings on Nerve Growth Factor, Spring 2002 Instructor, Biology 45: Readings on the Philadelphia Chromosome, Spring 2003 Instructor, Biology 45: Readings on Autoimmunity and Molecular Mimicry, Spring 2004 WATU (Writing Across the University) Preceptor, 2004 (I created the concept for the Biology 45 course as well as its curriculum. The course exposed undergraduates to reading and writing scientific literature. Students learned critical analysis of journal articles, how to perform peer review, and wrote a small grant. The course satisfied the college writing requirement and was listed in the honors curriculum)

Vanderbilt University MSTP Career Day, Session Leader on Residencies. 2007. 2009 Resident Advisor, Vivien Thomas (MSTP) Advising College, 2007-2011 MSTP Orientation, Choosing a Lab, 2009-2010 Course Director, M&IM 3283 (Graduate Course in Cellular and Molecular Immunology) Fall 2012 Instructor, M&IM 3283 (Graduate Course in Cellular and Molecular Immunology; 10 contact hours yearly), Fall 2013/2014 Career Day for 2nd Year Pediatric Residents (Physician Scientist Track) Fall 2012 Small Group Leader, Microbial Topics (VMS1), Spring 2013 Career Day for MSTP Students, Panel Discussant Fall 2013 Course Director, Pediatric Endocrine Conference (1.25CME credits) 2007-8, 2012-pres Preceptor, Careers in Medicine Elective, 2008-pres Preceptor, Amos Christie Scholars Program, 2009-pres Advisor, Garrod Society (Pediatric Resident Research Society), 2009-pres Pediatric Endocrine Fellowship Development Committee, 2010-pres Faculty Advisor (Advising College Leader, Goodpasture College), MSTP Program, 2011-pres Associate Director, Fellowship Program in Pediatric Endocrinology 2012-pres Course Creator/Director, Pediatric Diabetes in the Clinical and Research Settings (VMS3 Elective) 2012-pres Instructor, Foundations in Immunology (5 contact hours), Spring 2015 Other National Mentoring Experience Mentor, Lawson Wilkins Pediatric Endocrine Society

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Trainees: Daniela Buscariollo, VUMC Emphasis Project, 2008-2012 Selected to DRTC Summer Research Training Program (2008) Pamela Krajewski, APS/SPR Summer Program, Summer 2010

Selected to DRTC Summer Research Training Program (2010) Winner, Pediatric Academic Societies SPR Travel Award (2011)

Analise Thomas, VUMC Emphasis Project, 2011-2013

Selected to DRTC Summer Research Training Program (2011) Recipient of Darlene Batey Hoffman Scholarship (2011) Winner, Starr Medical Student Research Award from the Association of Women Surgeons (2012) Third Place, American College of Surgeons Oral Competition (out of >200 applicants) (2012)

E-beth Ockermann, University of TN Medical Student, Summer 2013 Selected to NIDDK Summer Research Program at Vanderbilt

Winner, Medical Student Research Award, Pediatric Research Day, LeBonheur Children’s Hospital (2013)

Danielle Curran, Vanderbilt Undergraduate, 2011-2014 Blair Stocks, MSTP Dissertation Student, July 2012-pres Recipient of Thomas Huggins Winn Memorial Scholarship (2013)

Winner, SPR/PAS Student Research Prize (2014) Young Innovator Award, American Society of Transplantation (2015) Young Investigator Award, American Association of Immunologists Winner, Elliot Newman Prize (top research by Vanderbilt student/resident) (2015)

Chris Wilson, IGP Dissertation Student, May 2012-pres

Selected to Howard Hughes Medical Institute, Certificate Program in Molecular Medicine (2012-2015)

Selected to CBMS Training Grant (2012-2014) Winner, Immunology of Diabetes Society Travel Award (2015) Recipient NIH NRSA F31DK107321, “Targeting B lymphocyte Signaling to

Reprogram Autoimmunity in Type 1 Diabetes” Recipient of SMART Award Best Poster Award, CPMM Retreat 2015

Karishma Datye, Pediatric Endocrine Fellow, June 2013-pres Selected to PES Spring Retreat (2014)

Recipient of Endocrine Fellows Foundation Diabetes, Obesity, and Metabolism Research Grant, “Assessing Barriers to Adherence in Adolescents with T1D”

Stephen Owen, Vanderbilt Summer Diabetes Research Program, Summer 2014

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Clemson Undergraduate Student, one of two students selected to VSDRC within the Vanderbilt Summer Science Academy (VSSA) Winner, SPR Student Research Award (2015)

Courtney Altschuler, USC Keck School of Medicine Student, Summer 2014 Selected to Vanderbilt Diabetes Center Summer Research Training Program (2014) Allison Pollock, Fellow at University of Wisconsin, 2014-pres Mentor through Pediatric Endocrine Society Research Council Selected to PES Spring Retreat (2015) David Meehan, Vanderbilt Summer Diabetes Research Program, Summer 2015

Univ. of Tennessee Undergraduate Student, one of two students selected to VSDRC within the Vanderbilt Summer Science Academy (VSSA)

Trainees (Pediatric Endocrine Fellowship) Jessica Lilley (Present, Assistant Professor, Univ. of Mississippi), 2010-2013 Justin Gregory (Present, Instructor, Vanderbilt), 2011-2014 Yaa Kumah-Crystal (Present, Instructor, Vanderbilt), 2011-2014 Melissa Garganta, 2013-pres Karishma Datye, 2013-pres Jamie Felton, 2014-pres Selorm Adzaku, 2015-pres Scholarship Oversight Committees Joann Romano-Keeler, Fellow in Neonatology (PI: Hendrik Weitkmap) 2010-pres Jessica Mouledoux, Fellow in Pediatric Cardiology (PI: William Walsh) 2011-2014 Ashley Wilhelm, Post-doctoral Fellow (PI: Amy Major) 2012-pres Karishma Datye, Fellow in Pediatric Endocrinology (PI: Sarah Jaser/Dan Moore) 2014-pres Co-Advisor for MSCI thesis

Jamie Felton (chair of SOC), Fellow in Pediatric Endocrinology (PI: Tom Thomas) 2015-pres

Dissertation Committees Yin Guo (PI: Ed Sherwood) 2012-pres

Blair Stocks (PI: Dan Moore) 2013-pres Chris Wilson (PI: Dan Moore) 2013-pres Jillian Rhoads, Chair (PI: Amy Major) 2013-pres Judy Brown (PI: Terry Dermody) 2015-pres Journal Review: Diabetes

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Journal of Immunology American Journal of Transplantation Annals of the New York Academy of Science Medical Hypotheses Current Medicinal Chemistry Pediatric Diabetes Journal of Translational Medicine Endocrinology Pediatrics Journal of Virology Transplantation Immunology BMC Medicine Journal of Diabetes and Its Complications Journal of Clinical Endocrinology and Metabolism Journal of Clinical Immunology PLOS One American Journal of Bioethics ISME Journal Gut Microbes Minerva Pediatrics FASEB Journal Protein Purification-Principles and Trends AJP-Endocrinology and Metabolism World Journal of Gastroenterology Diabetes Metabolism/Research and Reviews Pediatric Research Grant and Other Review Diabetes UK Small Grants Program Consortium Proposal Review Regular Grants Reviewer American Association for the Advancement of Science Indo-US Science and Technology Forum Review Research Competitiveness Program, Reviewer King Abdulaziz City for Science and Technology (KACST), Reviewer American Diabetes Association ADA-GSK Microbiome Awards Early Career Review (ECR) Program, NIH CSR Pediatric Academic Societies Meeting

Workshop Reviewer Research Council UK, Biotechnology and Biological Sciences Research Council Ad hoc reviewer Vanderbilt Diabetes Center, Pilot and Feasibility Reviewer Immune and Prevention Training Award Review Panel, JDRF

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Honors and Awards: National Merit Scholar 1992 John Harvard Scholarship Recipient 1992-1996 Harvard University Class of 1956 Memorial Scholarship 1993-1996 Phi Beta Kappa, Harvard University 1996 Summa Cum Laude, Harvard University 1996 Endocrine Society Medical Student Achievement Award 2003 David Karzon Award (Vanderbilt Dept. of Pediatrics Resident Research Award) 2007 Joe Strayhorn Award (Best Pediatric Grand Rounds) 2007 Lawson Wilkins Pediatric Endocrine Society Presidential Poster Selection 2007 Society for Pediatric Research House Officer Research Award 2007 Karolinska Award 2008 Genentech Clinical Scholars Travel Award 2009 NIH Pediatric Loan Repayment Program 2009-pres Eli Lilly Travel Award 2009, 2010 Vanderbilt Scholar in Diabetes 2009 TN Med Association Top Poster 2010 Elliott V. Newman Prize 2010 Alice and Henry Hooker Diabetes Research Scholar 2010 Focus on the Cure Award (JDRF Middle TN) 2012 Invited Lectures: Vanderbilt Dept. of Pediatrics Grand Rounds. Jan, 2007. “Taming Autoimmune Diabetes with a New Class of Magic Bullets”. Vanderbilt Dept. of Rheumatology Grand Rounds. March, 2007. “B Lymphocytes: Friends or Foes in T cell Tolerance”. Vanderbilt Dept. of Pediatrics Grand Rounds. August, 2007. “Will the Shots Ever End? An Update on Clinical Trials for Type 1 Diabetes”. Cincinnati Children’s Hospital. November, 2009. “B Lymphocytes at the Intersection of Inflammation and Immune Tolerance”. Diabetes Update presented by Vanderbilt Diabetes Center. August 2010. “Diabetes 101”.

Einstein Medical College. November 2010. “The Pivotal Role of B Lymphocytes in Immune Tolerance Decisions.”

University of Alabama at Birmingham. UAB Diabetes Day. May 2011. “Targeting the Nuclear Import Shuttle Resolves Insulitis and Arrests Type 1 Diabetes”.

University of Massachusetts. Diabetes Seminar. June 2011. “The Role of B Lymphocytes in Immune Regulation and Dysregulation”.

University of Alabama at Birmingham. Diabetes Center Seminar. July 2011. “Unlocking the Potential of B Lymphocytes For Immune Regulation in Type 1 Diabetes”.

Indiana University-Purdue University. Herman Wells Pediatric Seminar Series. Sept 2011. “Unlocking the Potential of B Lymphocytes For Immune Regulation in Type 1

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Diabetes” Diabetes Update presented by Vanderbilt Diabetes Center. Sept 2011. “Diabetes 101”.

Univesity of Massachussetts Diabetes Seminar. May 2012. “Identifying Regulatory Cell Insufficiency in Type 1 Diabetes”.

Endocrinology Grand Rounds. Vanderbilt University. May 2012. “Frontiers in Type 1 Diabetes Immunology

JDRF Middle TN Annual Conference. June 2012 “A Journey on the Path of Type 1 Diabetes”.

SouthEastern Lipid Research Conference. Sept 2012. “Overexpression of CD36 in the Murine Model of Type 1 Diabetes”.

Pediatric Academic Societies. May 2013. Worskshop Leader. “A Practical Guide towards Developing Your Laboratory’s Human Microbiome Studies”. [Worskhop approved as part of the Core Curriculum requirements for Pediatric Fellowship Subspecialty Training] Southern Pediatric Endocrine Society, October 2013. “Career Development in Academic Medicine” Diabetes Family Day, Vanderbilt University, November 2013. “A Superheroes Guide to Diabetes Research” Pediatric Emergency Department Conference. Vanderbilt University, May 2014. “DKA Management” Diabetes Update Keynote Speaker. Sept 2014. “Fundamentals of Diabetes Management Today and Tomorrow”. HHMI Bench-to-bedside Symposium Keynote. Sept 2014. “Diabetes Yesterday, Today, and Tomorrow”. Resident Board Review Series. Sept 2014. “Basics of Type 1 Diabetes”.

University of Utah. Visiting Professor. Dec 2014. Pediatric Research Conference “A Family-Centered Approach to Understanding the Immunology of T1D”

University of Utah. Visiting Professor. Dec 2014. Immunology Research Conference “Harnessing Regulatory Lymphocytes For Islet Protection in T1D”.

Human Growth Foundation Education Conference. April 2015. “Diabetes Mellitus in Children” Media Coverage

Sept. 11, 2013, News Channel 5. “Feature on T1D TrialNet Oral Insulin Study” November 2013, Featured Guest on Rx for Healthy Lifestyles. “T1D TrialNet at Vanderbilt”-Shown on RFD-TV with distribution to 40 million homes. October 2014, JDRF Interview. “Defining the Early Stages of Type 1 diabetes”. http://vimeo.com/111213628

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Advocacy Work Expert Testimony to TN State Legislature on ADA “Safe in Schools” Bill resulting in passage of bill in 2014 Grant Awards Juvenile Diabetes Research Foundation Summer Research Fellowship 1994 Howard Hughes Medical Institute Fellowship, First alternate 1998 American Diabetes Association Physician Scientist Training Grant 1998-2001 Medical Scientist Training Program Grant 1997-2004 NIH Ruth L. Kirschstein NRSA Fellowship (1F32DK083161-01) 2008-2011 PI:Moore (mentors: Jacek Hawiger and James W. Thomas) Title: Intracellular Targeting of Proinflammatory Pathways to Ameliorate Type 1 Diabetes Source: NIH Amount: 158, 937 Endocrine Fellows Foundation Research Grant 2008-2009 PI: Moore Source: Endocrine Fellows Foundation Amount: 7500 Vanderbilt Physician Scientist Development Program 2010-2011 Title: Harnessing B Lymphocytes as Antigen Specific Regulators of Islet Tolerance PI:Moore (mentors: Jacek Hawiger and James W. Thomas) Source: Vanderbilt Amount: 75,000/yr Vanderbilt Diabetes Center Pilot and Feasibility Grant 2011-2013 Title: The Microbial Ecology of Immune Tolerance in Type 1 Diabetes PI: Moore Amount: 40,000/yr NIH Career Development Award (1K08DK090146-01) 2011-2014 PI:Moore (mentors: Jacek Hawiger and James W. Thomas) Title: Harnessing B Lymphocytes as Antigen Specific Regulators of Islet Tolerance Source: NIH Turner Hazinski Scholar Award 2011-2013 PI: Moore Title: Unlocking the Regulatory Potential of B lymphocytes To Restore Immune Tolerance in T1D Amount: 75,000/yr

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NIH Small Grant Program (1R03DK097410) 2012-2014 PI:Moore Title: Restoration of Immune Tolerance in Type 1 Diabetes Source: NIH Amount: 50,000/yr (direct costs) Leona B and Harry M Helmsley Trust 2014-2015 Breakthrough Therapeutics Initiative PI:Moore Title: A Targeted Approach to Measure and Deplete Autoreactive Lymphocytes in T1D Amount: 100,000 (total costs) Strategic Research Agreement (3-SRA-2014-40-Q-R) 2014-2017 PI:Guoqiang Gu (Role: Co-investigator) Title: Excretable short RNAs and glucuronides in stressed beta cells and diabetes Source: JDRF Amount: 225,000/yr (direct costs) Career Development Award (5-CDA-2014-209-A-N) 2014-2019 PI:Moore Title: Mapping a Cure By Defining the B Lymphocyte Signaling Network Source: JDRF Amount: 135,000/yr (direct costs) Strategic Research Agreement (3-SRA-2014-102-M-B) 2015-2018 PI: Jack Virostko (Role: Co-investigator) Title: Quantitative MRI of the Pancreas in Type 1 Diabetes Source: JDRF Amount: 200,000/yr (total costs) NIH Ruth L. Kirschstein NRSA Fellowship (1F31DK107321-01A1) 2015-2018 PI: Christopher Wilson Role: Sponsor Title: Targeting B Lymphocyte Signaling to Reprogram Autoimmunity in Type 1 Diabetes Source: NIH Amount: 83.520 Patents 1. US Patent 20,130,089,528. Jacek Hawiger, Robert Collins, Daniel J Moore, Jozef Zienkiewicz, RuthAnn Veach. Compositions and methods for preserving insulin-producing cells and insulin production and treating diabetes. 4/11/2013. Publications and Presentations: Journal Articles

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Original Articles 1. Hideki Shimada, Sharon Germana, Kai C. Sonntag, Papia Banerjee, Daniel Moore,

David H. Sachs, and Christian LeGuern. 1999. MHC class II alpha/beta heterodimeric cell surface molecules expressed from a single proviral genome. Human Gene Therapy 10:2397.

2. Hooman Noorchashm, Daniel J. Moore, Yien K. Lieu, Negin Noorchashm, Alexander Schlachterman, Howard K. Song, Clyde F. Barker, and Ali Naji. 1999. Contribution of the innate immune system to autoimmune diabetes: a role for the CR1/CR2 complement receptors. Cellular Immunology 195:75.

3. Hooman Noorchashm, Daniel J. Moore, Lauren E. Noto, Negin Noorchashm, Amy J. Reed, Alison L. Reed, Howard K. Song, Reza Mozaffari, Anthony M. Jevnikar, Clyde F. Barker, and Ali Naji. 2000. Impaired CD4 T Cell Activation Due to Reliance Upon B Cell-Mediated Costimulation in Nonobese Diabetic (NOD) Mice. J Immunol 165:4685.

4. J. Brad Kline, Daniel J. Moore, and Charles V. Clevenger. 2001. Activation and association of the Tec tyrosine kinase with the human prolactin receptor: mapping of a Tec/Vav1-receptor binding site. Molecular Endocrinology 15:832.

5. Siri A. Greeley, Daniel J. Moore, Hooman Noorchashm, Lauren E. Noto, Susan Y. Rostami, Alexander Schlachterman, Howard K. Song, Birgitte Koeberlein, Ckyde F. Barker, and Ali Naji. 2001. Impaired activation of islet-reactive cd4 t cells in pancreatic lymph nodes of b cell-deficient nonobese diabetic mice. J Immunol 167:4351

6. Ergun Velidedeoglu, Beth Jarrett, Major K. Lee, Daniel Moore, Xiaolun Huang, Shaoping Deng, M.M. Lian, Andrew Caton, and James F. Markmann. 2002. Transgenic T cell persist in an adoptive transfer model of mouse liver transplantation tolerance. Transplantation Proceedings 34:3342-3344.

7. Jose Trani, Daniel J. Moore, Beth Jarrett, JosephW. Markmann, Major K. Lee, M. Lian, Brian Tran, Andrew J. Caton, and James F. Markmann. 2003. Evidence for both clonal deletion and induction of CD25+ immunoregulatory T cells in acquired central transplantation tolerance. J. Immunol 170: 279.

8. Siri Atma W. Greeley, Makoto Katsumata, Liping Yu, George S. Eisenbarth, Daniel J. Moore, Heidi Goodarzi, Clyde F. Barker, Ali Naji, and Hooman Noorchashm. 2002. Elimination of maternally transmitted autoantibodies prevents diabetes in non-obese diabetic mice. Nature Medicine 8: 399. [article listed as must read by Faculty of 1000].

9. Howard K. Song, Hooman Noorchashm, Tina H. Lin, Daniel J. Moore, Siri A. Greeley, Andrew J. Caton, and Ali Naji. 2003. Specialized CC-chemokine secretion by Th1 cells in destructive autoimmune myocarditis. J Autoimmun. Dec; 21(4):295-303.

10. Major K. Lee IV, Xiaolun Huang, Beth P. Jarrett, Daniel J. Moore, Niraj M. Desai, Moh Moh Lian, Joseph W. Markmann, Shaoping Deng, Adam Frank, Ergun Velidedeoglu, Andrew Caton, and James F. Markmann. 2003. Vulnerability of allografts to rejection by class II restricted T cell receptor transgenic mice. Transplantation 75(8): 1415-1422.

11. Major K. Lee IV, Daniel J. Moore (joint first authorship), Beth P. Jarrett, Moh

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Moh Lian, Shaoping Deng, Xiaolun Huang, Joseph W. Markmann, Andrew J. Caton, and James F. Markmann. 2004. Promotion of allograft survival by CD4+CD25+ regulatory T cells: evidence for in vivo inhibition of effector cell proliferation. J Immunol. Jun 1;172(11):6539-44.

12. Daniel J. Moore, Xiaolun Huang, Moh Moh Lian, James F. Markmann, and Shaoping Deng. 2004. Resistance to anti-CD45RB induced tolerance in NOD mice: mechanisms involved. Transplantation International. Jun;17(5):261-9.

13. Daniel J. Moore, Hooman Noorchashm, Tina H. Lin, Siri A. Greeley, and Ali Naji. 2005. NOD B lymphocytes are insufficient to incite T-cell mediate anti-islet autoimmunity. Diabetes 54(7) 2019-2025. [article listed as recommended by Faculty of 1000]

14. Greg Wilde, Daniel J. Moore, and Richard Bellah. 2005. Posttransplantation lymphoproliferative disorder in pediatric recipients of solid organ transplants. Am. Jr. Roentgenol. 185(5): 1335-41.

15. Shaoping Deng, Daniel J. Moore, Xiaolun Huang, Mohammad Mohiuddin, Major K. Lee IV, Ergun Velidedeoglu, Moh-Moh Lian, Meredith Chiaccio, Samsher Sonawane, Anton Orlin, Haiying Chen, Andrew Caton, Robert Zhong, and James F. Markmann. 2006. Antibody-induced transplantation tolerance that is dependent on thymus-derived regulatory T cells. J Immunol. Mar 1;176(5), 2799-807.

16. Major K. Lee IV, Daniel J. Moore, Meredith Chiaccio, Moh Moh Lian, Shaoping Deng, Mohammad Mohiuddin, Xiaolun Huang, Birgitte Koeberlein, A, Zakheim, Paige Porrett, Clyde Barker, Andrew J. Caton, and James F. Markmann. 2006. T-reg mediated suppression of the allograft response in the draining lymph node. Transplantation. 81(7): 1063-66.

17. Shaoping Deng, Daniel J. Moore (joint first authorship), Xiaolun Huang, Moh-Moh Lian, Mohammad Mohiuddin, Ergun Velededeoglu, Major K. Lee IV, Samsher Sonawane, James Kim, Jing Wang, Mark Shlomchik, Andrew Caton, and James F. Markmann. 2007. Cutting Edge: transplant tolerance induced by anti-CD45RB requires B lymphocytes. J, Immunol. May 15;178(10):6028-32.

18. Xiaolun Huang, Daniel J. Moore (joint first authorship), Muhammad Mohuiddin, Moh-Moh Lian, James Kim, Samsher Sonawane, Jing Wang, Yi Gu, Heidi Yeh, James F. Markmann, and Shaoping Deng. 2008. Rapid Communication: Inhibition of ICAM-1/LFA-1 interactions prevents B cell dependent anti-CD45RB induced tolerance. Transplantation, March 15; 85(5): 675-80.

19. Paige M. Porrett, Major K. Lee IV, Moh Moh Lian, Jing Wang, Andrew J. Caton, Shaoping Deng, James F. Markmann and Daniel J. Moore. 2008. A direct comparison of rejection by CD8 and CD4 T cells in a transgenic model of allotransplantation. Archivum Immunologiae et Therapiae Experimentalis. June 15; 56(3): 193-200.

20. Daniel J. Moore. 2009. Accounting for chance in the calculus of autoimmune disease. Medical Hypotheses. Feb. 74(2): 289-93.

21. Peggy L. Kendall, Daniel J. Moore, Chrys Hulbert, Kristin Hoek, Wasif Kahn, and James W. Thomas. 2009. Reduced diabetes in Btk deficient nonobese diabetic mice and restoration of diabetes by provision of an anti-insulin IgH transgene. J. Immunol, Nov 15; 183(10): 6403-12.

22. James I. Kim, Major K. Lee IV, Daniel J. Moore, Samsher B. Sonawane, Patrick E

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Duff, Matthew R O’Connor, Heidi Yeh, Moh Moh Lian, Shaoping Deng, Andrew J. Caton, and James F. Markmann. 2009. Regulatory T cell counter-regulation by innate immunity is a barrier to transplantation tolerance. American Journal of Transplantation. Oct 21. 9(12): 2736-44.

23. Samsher B. Sonawane, James I. Kim, Major K. Lee, Seoung-Hoon Lee, Patrick E. Duff, Daniel J. Moore, Moh-Moh Lian, Shaoping Deng,, Yongwon Choi, Heidi Yeh, Andrew J. Caton, James F. Markmann. 2009. GITR blockade facilitates T-reg mediated allograft survival. Transplantation. Nov 27; 88(10):1169-77.

24. Gaoping Zhao, Daniel J. Moore, KM Lee, James I. Kim, Patrick E. Duff, Mathew R. O'Connor, T. Hirohashi, J. Lei, M. Yang, James F. Markmann, and Shaoping Deng. 2010. An unexpected counter-regulatory role of Il-10 in B lymphocyte-mediated transplantation tolerance. American Journal of Transplantation. Feb 25. 10(4): 796-801

25. Daniel J. Moore, Jozef Zienkiewicz, Peggy L. Kendall, Danya Liu, Xueyan Liu, Ruth A. Veach, Robert D. Collins, and Jacek Hawiger. 2010. In Vivo Islet Protection by a Nuclear Import Inhibitor in a Mouse Model of Type 1 Diabetes. PLOS One. Oct 6;5(10):e13235. [article listed as recommended by Faculty of 1000]

26. Gaoping Zhao, Daniel J. Moore, James I. Kim, Kang Mi Lee, Matthew R. O’Connor, Patrick E. Duff, Maozhu Yang, Ji Lei, James F. Markmann, Shaoping Deng. 2011. Inhibition of Transplantation Tolerance by Immune Senescence is Reversed by Endocrine Modulation. Science Translational Medicine. Jun 15;3(87).

27. Orban T, Bundy B, Becker DJ, Dimeglio LA, Gitelman SE, Goland R, Gottlieb PA, Greenbaum CJ, Marks JB, Monzavi R, Moran A, Raskin P, Rodriguez H, Russell WE, Schatz D, Wherrett D, Wilson DM, Krischer JP, Skyler JS; the Type 1 Diabetes TrialNet Abatacept Study Group (*Member of the Study Group). 2011. Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial. Lancet. Jun 28.

28. Jörn-Hendrik Weitkamp, Tatsuki Koyama, Michael T. Rock, Hernan Correa, Jeremy A. Goettel, Pranathi Matta, Kyra Oswald-Richter, Michael J. Rosen, Brian G. Engelhardt, Daniel J. Moore, D. Brent Polk. 2012. Diminished mucosal regulatory (FOXP3+) / effector (CD4+, CD8+) T cell ratios as evidence for disrupted immune regulation in necrotizing enterocolitis. Gut. Jan;62(1):73-82

29. Brian G. Engelhardt, Shubhada M Jagasia, James E. Crowe, Jr., Michelle L. Griffith, Bipin N. Savani, Adetola A. Kassim, Pengcheng Lu, Jörn-Hendrik Weitkamp, Daniel J. Moore, Sandra M. Yoder, Michael T. Rock, Madan Jagasia. 2012. Predicting post-transplant diabetes mellitus by regulatory T cell phenotype: Implications for metabolic intervention to modulate alloreactivity, Blood. Mar 8;119(10):2417-21.

30. Qing Lin, Yan Liu, Daniel J. Moore, Sydney K. Elizer, Jacek Hawiger, and H. Earl Ruley. 2012. Cutting Edge: The “Death” Adaptor CRADD/RAIDD Targets BCL10 and Suppresses Agonist-Induced Cytokine Expression in T Lymphocytes. J. Immunol, Mar 15;188(6):2493-7.

31. Yu L, Boulware DC, Beam CA, Hutton JC, Wenzlau JM, Greenbaum CJ, Bingley PJ, Krischer JP, Sosenko JM, Skyler JS, Eisenbarth GS, Mahon JL; Type 1 Diabetes TrialNet Study Group (member of study group). 2012. Zinc

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transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies. Diabetes Care. Jun;35(6):1213-8.

32. Daniela L. Buscariollo, Mario A. Davidson, Margo S. Black, William E. Russell, Russell Rothman, and Daniel J. Moore. 2012. “Factors that influence parental attitudes toward enrollment in Type 1 diabetes trials”. PLOS One. Aug;(8):e44341.

33. Jack Virostko, Aramandla Radhika, Greg Poffenberger, Adrienne N. Dula, Daniel J. Moore, Alvin C. Powers. 2013. Bioluminescence Imaging Reveals Dynamics of Beta Cell Loss in the Non-obese Diabetic (NOD) Mouse Model. PLOS One. Mar;8(3): e57784.

34. Yan Liu, Amy S. Major, Jozef Zienkiewicz, Curtis Gabriel, Ruth Ann Veach, Daniel J. Moore, Robert Collins, and Jacek Hawiger. 2013. Nuclear Transport Modulation Reduces Hypercholesterolemia, Atherosclerosis, and Fatty Liver. Journal of the American Heart Association. Apr 5;2(2):e000093.

35. Diabetes Research in Children Network (DirecNet) and Type 1 diabetes TrialNet Study Groups (member of both study groups). 2013. The effects of inpatient hybrid closed-loop therapy initiated within 1 week of Type 1 diabetes diagnosis. Diabetes Technol Ther. Apr 9.

36. Jay M. Sosenko, Jay S. Skyler, Jerry P. Palmer, Jeffrey P. Krischer, Liping Yu, Jeffrey Mahon, Craig A. Beam, David C. Boulware, Lisa Rafkin, Desmond Schatz, George Eisenbarth, the Type 1 Diabetes TrialNet (member of study group) and the Diabetes Prevention Trial–Type 1 Study Groups. 2013. The Prediction of Type 1 Diabetes by Multiple Autoantibody Levels and Their Incorporation Into an Autoantibody Risk Score in Relatives of Type 1 Diabetic Patients. Diabetes Care. July 17; 36(9): 2615-2620.

37. Jay M. Sosenko, Jay S. Skyler, Craig A. Beam, Jeffrey P. Krischer, Carla J. Greenbaum, Jeffrey Mahon, Lisa E. Rafkin, Della Matheson, Kevan C. Herold, Jerry P. Palmer, The Diabetes Type 1 TrialNet (member of study group) and Diabetes Prevention Trial-Type 1 Study Groups. 2013. Acceleration of the Loss of the First-Phase Insulin Response during the Progression to Type 1 Diabetes in Diabetes Prevention Trial-Type 1 Participants. Diabetes Dec;62(12):4179-83..

38. Bruce Buckingham, Roy W. Beck, Katrina J. Ruedy, Peiyao Cheng, Craig Kollman, Stuart A. Weinzimer, Linda A. DiMeglio, Andrew A. Bremer, Robert Slover, William V. Tamborlane, Diabetes Research in Children Network (DirecNet) and Type 1 Diabetes TrialNet Study Groups (member of both study groups). 2013. Effectiveness of Early Intensive Therapy on β-Cell Preservation in Type 1 Diabetes. Diabetes Care. Dec;36(12): 4030-5.

39. Jessica H. Mouledoux (fellow trainee), Erin L. Albers, Zengqi Lu, Benjamin R. Saville, Daniel J. Moore, Debra A. Dodd. 2013. Clinical Predictors of Autoimmune and Severe Atopic Disease in Pediatric Heart Transplant Recipients. Pediatric Transplantation, Mar;18(2): 197-203.

40. Tihamer Orban T, Brian Bundy, Dorothy J Becker, Linda A Dimeglio, Steven E Gitelman, Robin Goland, Peter A Gottlieb, Carla J Greenbaum, Jennifer B Marks, Roshanak Monzavi, Antoinette Moran, Mark Peakman, Philip Raskin, William E Russell, Des Schatz, Diane K Wherrett, Darrell m Wilson, Jeffrey Krischer, Jay Skyler, The Type 1 Diabetes TrialNet Abatacept Study Group (member of

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study group). 2014. Co-Stimulation Modulation with Abatacept in Patients with Recent-Onset Type 1 Diabetes: Follow-Up One Year After Cessation of Treatment. Diabetes Care. Apr;37(4):1069-75.

41. Joann Romano-Keeler, Daniel J. Moore, Robert Brucker, Christopher Fonnesbeck, Hernan Correa, Harold Lovvorn, Chunlin Wang, Seth Bordenstein, Yi Wei Tang, Alfred George, Jöern-Hendrik Weitkamp. 2014. Early life establishment of site-specific microbial communities in the gut. Gut Microbes, Mar; 5(2): 192-201.

42. Gaoping Zhao, Daniel J. Moore, James I. Kim, Kang Mi Lee, Matthew O'Connor, Maozhu Yang, Andrew F. Marshall, Ji Lei, Christian Schuetz, James F. Markmann, and Shaoping Deng. 2014. Induction of Species-Specific Tolerance to Human Islet Xenografts by anti-CD45RB. Xenotransplantation, Nov-Dec;21(6):567-73.

43. Jörn-Hendrik Weitkamp, Michael Rosen, Zhao Zhiguo, Tatsuki Koyama, Timothy L. Denning, Zhiguo Zhao, Michael T. Rock, Daniel J. Moore, Pranathi Matta, Patricia W. Denning. 2014. Small intestinal intraepithelial TCRgd lymphocytes protect against severe necrotizing enterocolitis. Plos One, Jun 6; 9(6):e99042.

44. Sydney K. Elizer, Andrew F. Marshall, and Daniel J. Moore. 2014. Dysregulation of T Lymphocyte Proliferative Responses in Autoimmunity. PLOS One, Aug 29;9(8):e10634.

45. Antonio DiGiandomenico, Ruth Ann Veach, Jozef Zienkiewicz, Daniel J. Moore,

Lukasz S. Wylezinski, Martha A. Hutchens,

and Jacek Hawiger. 2014. The

Genomic Storm Induced by Bacterial Endotoxin is Calmed by a Nuclear Transport Modifier that Attenuates Localized and Systemic Inflammation. PLOS One, Oct 20;9(10):e110183

46. Jay Sosenko, Jay Skyler, Linda DiMeglio, Craig A. Beam, Jeff Krischer, Carla Greenbaum, David Boulware, Lisa E Rafkin, Della Matheson, Kevan Herold, John Mahon, Jerry P. Palmer; Type 1 Diabetes TrialNet Study Group (member of study group); Diabetes Prevention Trial-Type 1 Study Group. A new approach for diagnosing type 1 diabetes in autoantibody-positive individuals based on prediction and natural history. Diabetes Care. 2015 Feb;38(2):271-6.

47. Christopher S. Wilson (graduate student), Sydney K. Elizer, Andrew F. Marshall, Blair T. Stocks (MSTP student), and Daniel J. Moore. 2014. The Regulation of B Lymphocyte Responses to TLR Ligation During Diabetes Prevention. J. Diabetes, in press.

48. Sosenko JM, Skyler JS, Beam CA, Boulware D, Mahon JL, Krischer JP, Greenbaum CJ, Rafkin LE, Matheson D, Herold KC, Palmer JP; Type 1 Diabetes TrialNet Study Group (member of study group) and Diabetes Prevention Trial–Type 1 Study Groups. 2015. The development and utility of a novel scale that quantifies progression toward type 1 diabetes over 6 months. Diabetes Care. 2015 May;38(5):940-2.

49. James L. Wynn, Philip O. Scumpia, Blair Stocks (MSTP Student), Joann Romano-Keeler (Faculty Advisee), Mhd Wael Alrifai, Jin-Hua Liu, Annette S. Kim, Catherine E. Alford, Pranthi Matta, Jörn-Hendrik Weitkamp, and Daniel J. Moore. 2015. Neonatal CD71+ erythroid cells do not modify murine sepsis mortality. Journal of Immunology, in press. [Highlighted “In this Issue” of the JI, August 2015]

50. Blair. T. Stocks (MSTP Student), Ashley J. Wilhelm, Christopher S. Wilson

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(graduate student), Andrew F. Marshall, Nicole E. Putnam (graduate student), Amy S. Major, and Daniel J. Moore. 2015. Lupus Prone Mice Resist Immune Regulation and Transplant Tolerance Induction. American Journal of Transplantation, in press.

51. Moh-Moh Lian, Adam Frank, Lingling Wei, Daniel J. Moore, Doris A. Stoffers, James F. Markmann, and Shaoping Deng. 2015. Insulin Therapy Potentiates the Effect of a Single Transcription Factor to Induce Beta Cell Neogenesis and Diabetes Reversal". Gene Therapy, under review.

52. Joann Romano-Keeler, Chunlin Wang, Robert M. Brucker, Daniel J. Moore, Christopher Fonnesbeck, Shufang Meng, Hernan Correa, Harold N. Lovvorn, III, Yi-Wei Tang, Lora Hooper, Seth Bordenstein, Alfred L. George, Jr., and Jörn-Hendrik Weitkamp. 2015. Staphylococcus Dysbiosis in Surgical Necrotizing Enterocolitis, in revision with PLOS One.

53. Blair T. Stocks (MSTP Student), Christopher S. Wilson (graduate student), Andrew F. Marshall, Nicole E. Putnam (graduate student), and Daniel J. Moore. 2015. Regulation of Immunity and Islet Injury by Ly49+ Regulatory CD8 T cells in Type 1 Diabetes. In revision with Diabetes.

54. Joann Romano-Keeler, Joseph Zackular, Daniel J. Moore, Robert M. Brucker, Christopher Hooper, Shufang Meng, Naoko Brown, Simon Mallal, Seth R. Bordenstein, David M. Aronoff, John Jeffrey Reese, and Jörn-Hendrik Weitkamp. 2015. Dynamic acquisition of the fetal microbiota during normal pregnancy. In review with ISME Journal.

55. James L. Wynn, Chris S. Wilson (graduate student), Philip O. Scumpia, Jin-Hua Liu, Jacek Hawiger, Hector R. Wong, Patrick Lahni, John T. Benjamin, Erin J. Plosa, Jörn Hendrik Weitkamp, Edward R. Sherwood, Lyle L. Moldawer, Ricardo Ungaro, Henry V. Baker, M. Cecilia Lopez, Steven J. McElroy, and Daniel J. Moore. 2015. Targeting a novel IL-18/IL-17 axis reduces mortality in neonatal sepsis, in preparation for Immunity.

56. Blair T Stocks (MSTP Student), Analise Thomas (Medical Student), Sydney Elizer, Yuantee Zhu (MSTP Student), Andrew F. Marshall, and Daniel J. Moore. 2015. Disruption of Hematopoietic Stem Cell Mobilization Prevents Transplantation Tolerance, in preparation for Amer. J. of Transplantation.

57. Andrew F. Marshall, Sydney K. Elizer, Blair T. Stocks (MSTP Student), Pamela Krajewski (Medical Student), Christopher S. Wilson (PhD Student), and Daniel J. Moore. 2015. GARP Identifies Regulatory Cell Insufficiency in Type 1 Diabetes, in preparation for Diabetes.

Review Articles (peer-reviewed) 1. Major K. Lee, Daniel J. Moore, and James F. Markmann. 2003. CD25+ regulatory

T cells in transplantation tolerance. Frontiers in Bioscience. 8, s968-981. 2. Daniel J. Moore, James F. Markmann, and Shaoping Deng. 2006. Avenues for

immunomodulation and graft protection by gene therapy in transplantation. Transplant International. Jun; 19(6):435-45.

3. Daniel J. Moore, James I. Kim, Samsher Sonawane, Heidi Yeh, Shaoping Deng, Major K. Lee IV, and James F. Markmann. 2007. Progress toward

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antibody-induced transplantation tolerance. Critical Reviews in Immunology. 27(2):167-218.

4. Xiaolun Huang, Daniel J. Moore (joint first authorship), Robert Ketchum, Craig S. Nunemaker, Boris Kovatchev, Anthony McCall, and Kenneth L. Brayman. 2008. Resolving the Conundrum of Islet Transplantation by Linking Metabolic Dysregulation, Inflammation, and Immune Regulation. Endocrine Reviews. Aug 4; 29(5): 603-30.

5. Daniel J. Moore, Justin M. Gregory, Yaa A. Crystal-Kumah, and Jill H. Simmons. 2009. Mitigating risk for micro- and macro-vascular complications in the adolescent with diabetes. Vascular Health and Risk Management. Nov 23;5:1015-31.

6. Justin M. Gregory, Jessica S. Lilley, Amanda A. Misfeldt, Daniela Buscariollo, William E. Russell, and Daniel J. Moore. 2010. Incorporating type 1 diabetes prevention into clinical practice. Clinical Diabetes. 28(2): 61-70.

7. Justin M. Gregory and Daniel J. Moore. 2011. Can Technological Solutions for Diabetes Replace Islet Cell Function? Organogenesis 7(1): 32-41.

8. Joann Romano-Keeler, Jorn-Hendrik Weitkamp, and Daniel J. Moore. 2012. Properties of the Intestinal Microbiome Effecting the Development and Treatment of Diabetes. Current Opinion in Endocrinology and Diabetes, Apr;19(2):73-80.

9. Heidi Yeh, Daniel J. Moore, James F. Markmann, and James I. Kim. 2013. Mechanisms of regulatory T cell counter-regulation by innate immunity. Transplantation Reviews. Apr;27(2):61-4.

10. Justin Gregory, Daniel J. Moore, and Jill H. Simmons. 2013. Type 1 Diabetes Mellitus. Pediatrics in Review. May;34(5):203-15

11. Karishma A. Datye, Daniel J. Moore, William E. Russell, and Sarah S. Jaser. 2015. A Review of Adolescent Adherence in Type 1 Diabetes and the Untapped Potential of Diabetes Providers to Improve Outcomes. Current Diabetes Reports. 15(8)

Case Reports 1. Daniel J. Moore, Bryce A. Nelson, Bradley J. VanSickle, and Revi P. Mathew.

2009. The Houssay phenomenon in a pediatric patient with Type 2 diabetes. EndoTrends. 16 (1): 1-4.

2. Revi P. Mathew and Daniel J. Moore. 2011. Auto-immune Alternating Hypo- and Hyper-thyroidism in Children. Clinical Pediatrics. June 23.

3. Ashley H. Shoemaker, Jozek Zienkiewicz, and Daniel J. Moore. 2012. Clinical assessment of HNF1A and GCK variants and identification of a novel mutation causing MODY2. 2012. Diabetes Res Clin Pract. Feb 15.

Abstracts from National Meetings 1. Daniel J. Moore, Tina H. Lin, Hooman Noorchashm, Siri Atma W. Greeley,

Lauren E. Noto, Clyde F. Barker, Ali Naji. Shared T Cell Dysfunction in Multiple Models of Autoimmunity. Diabetes, Supplement 2, Vol. 50, 2001.

2. Howard K. Song, Tina H. Lin, Hooman Noorchashm, Siri A. Greeley, Daniel J. Moore, Andrew J. Caton, and Clyde F. Barker. 1999. Specialized CC-chemokine secretion by heart-specific CD4+T cells contributes to their pathogenic potential in

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a novel model of autoimmune myocarditis. Circulation 100:3238. 3. J. Bradford Kline, Daniel J. Moore, and Charles V. Clevenger. 2000. Activation

and association of the Tec tyrosine kinase with the human prolactin receptor: Mapping of a Tec/Vav-receptor binding site. Molecular Biology of the Cell 11:1747

4. Jose L. Trani, Joseph W. Markmann, Alexander Schlachterman, Daniel J. Moore, Bryan J. Tran, Ines C. Lin, James F. Markmann. CD25+ CD4+ T Cells Are Induced in Acquired Central Tolerance. American Journal of Transplantation, Supplement 1, Vol 1. 2001.

5. Shaoping Deng, Haiying Chen, Daniel Moore, Z. Xing, James Markmann, and Robert Zhong. 2001. IL-4 cytokine gene transfer promotes anti-CD45RB induced long- term survival of islet xenografts. Xenotransplantation 8:551.

6. Shaoping Deng, Daniel Moore, Haiying Chen, Moh-moh Lian, Ergun Velidedeoglu, Robert Zhong, and James Markmann. 2001. Anti-CD45RB therapy prevents islet xenograft rejection by inhibition of indirect pathway and B cell activation. Xenotransplantation 8:25.

7. Shaoping Deng, Daniel J. Moore, Xiaolun Huang, Moh-Moh Lian, Haiying Chen, Robert Zhong, and James F. Markmann. Recipient B lymphocytes are required for anti-CD45RB induced tolerance to allografts. 2002. American Journal of Transplantation, Supp. 3, Vol. 2.

8. Xiaolun Huang, Beth Jarrett, Daniel J. Moore, Haiying Chen, Robert Zhong, Shaoping Deng, and James F. Markmann. Anti-CD45RB therapy prevents cardiac graft rejection in TCR-transgenic mice by induction of non-deletional peripheral tolerance. 2002. American Journal of Transplantation, Supplement 3, Vol. 2.

9. Shaoping Deng, Daniel J. Moore, Haiying Chen, Robert Zhong, and James F. Markmann. The effect and mechanism of anti-CD45RB induced tolerance to islet xenografts. 2002 American Journal of Transplantation, Supp. 3, Vol. 2.

10. Major Lee, Daniel J. Moore, Beth Jarrett, Xiaolun Huang, Joseph W. Markmann, Andrew J. Caton, and James F. Markmann. In vivo function of regulatory T cell (CD4+,CD25+) in a transgenic allograft model. 2002. American Journal of Transplantation, Supp. 3, Vol. 2.

11. Daniel J. Moore, Xiaolun Huang, Haiying Chen, Robert Zhong, James F. Markmann, and Shaoping Deng. NOD mice are resistant to anti-CD45RB induced tolerance. 2002 American Journal of Transplantation, Supp. 3, Vol. 2.

12. Beth Jarrett, Jose Trani, Daniel J. Moore, Bryan Tran, Moh Moh Lian, Major Lee, Joseph Markmann, Andrew Caton, and James Markmann. Regulatory T cell involvement in induced transplantation tolerance. 2002. American Journal of Transplantation, Supp. 3, Vol. 2.

13. Joseph W. Markmann, Jing Wang, Andrew E. Gelman, Daniel Moore, Susan M. Lerner, Jose L. Trani, C. Burke, Steven M. Raper, and James F. Markmann. Autoantigen Gene Transfer to Prevent Autoimmune Diabetes. Penn Diabetes Symposium 2002

14. Daniel J. Moore and Ali Naji. 2002. Promotion of Tolerance in the Presence of NOD B Cells: A Role for B Cell-APC Synergy. Diabetes, Supplement 2, Vol. 51.

15. Xiaolun Huang, Daniel J. Moore, Moh-Moh Lian, Haiying Chen, Robert Zhong, James Markmann and Shaoping Deng. 2003. Thymus dependent regulatory T cells mediate transplantation tolerance induced by Anti-CD45RB. American Journal of

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Transplantation, Supplement 5, Vol 3. 16. Major K. Lee IV, Daniel J. Moore , Xiaolun Huang, Meredith Chiaccio, Shaoping

Deng, Andrew J. Caton, and James F. Markmann. 2003. CD4+CD25+ T cell function in a transgenic allograft model. American Journal of Transplantation, Supplement 5, Vol 3.

17. Muhammad Mohiuddin, Shaoping Deng, Daniel J. Moore, Xiaolun Huang, Ergun Velidedeoglu, Moh Moh Lian, Yong Suk Bae, Major K. Lee IV, Meredith Chiaccio, Haiying Chen, and James F. Markmann. 2003. Mechanism of anti-CD45RB induced tolerance: functionally active B lymphocytes persist indefinitely in B cell reconstituted mu KO mice made tolerant to allograft with B cell reconstitution and anti-CD45 treatment. Basic Science Symposium: Transplantation Tolerance in the Real World

18. Xiaolun Huang, Daniel J. Moore, Major K. Lee IV, Moh Moh Lian, Meredith Chiaccio, Haiying Chen, Robert Zhong, Shaoping Deng, and James F. Markmann. 2003. Anti-CD45RB therapy induces thymus-dependent central tolerance in a TCR transgenic mouse transplant model. Basic Science Symposium: Transplantation Tolerance in the Real World.

19. Daniel J. Moore, Xiaolun Huang, Muhammad Mohiuddin, Ergun Velidedeoglu, Major K. Lee IV, Moh Moh Lian, Meredith Chiaccio, Haiying Chen, Robert Zhong, James Markmann, and Shaoping Deng. 2003. B cells function as a critical link in anti-CD45RB induced central tolerance. Basic Science Symposium: Transplantation Tolerance in the Real World.

20. Major K. Lee IV, Daniel J. Moore, Beth P. Jarrett, Meredith Chiaccio, Moh Moh Lian, Joseph W. Markmann, Shaoping Deng, Xiaolun Huang, Muhammad Mohiuddin, Andrew J. Caton, and James F. Markmann. 2003. “Danger” signals regulate CD4+CD25+ T cells. Basic Science Symposium: Transplantation Tolerance in the Real World.

21. Major K. Lee IV, Daniel J. Moore, Meredith L. Chiaccio, Moh Moh Lian, Shaoping Deng, Xiaolun Huang, Muhammad Mohiuddin, Andrew J. Caton, Clyde F. Barker, James F. Markmann. 2004. T-reg mediated suppression of the allograft response in the draining lymph node. American Journal of Transplantation, Vol. 4, Supplement 8.

22. Daniel J. Moore, Xiaolun Huang, Muhammad M. Mohiuddin, Major K. Lee, Meredith Chiaccio, Haiying Chen, Moh-Moh Lian, Robert Zhong, James F. Markmann, Shaoping Deng. 2004. Comparative analysis of tolerance induction in NOD and NOR mice reveals a role for APC function in anti-CD45RB induced tolerance. American Journal of Transplantation, Vol. 4, Supplement 8.

23. Adam M. Frank, Yong Suk Bae, Moh Moh Lian, Thavachenthan Thambi-Pillai, Daniel Moore, Hooman Noorchashm, James F. Markmann, Shaoping Deng. 2004. Survival advantatge of discordant xenografts in diabetic BDC2.5/NOD mice. American Journal of Transplantation, Vol. 4, Supplement 8.

24. Muhammad M. Mohiuddin, Daniel J. Moore, Xiaolun Huang, Ergun Velidedeoglu, Moh M. Lian, Major K. Lee, Yong Suk Bae, Adam M. Frank, Meredith Chiaccio, Haiying Chen, James F. Markmann, Shaoping Deng. 2004. The role of B cells in tolerance induced by anti-CD45RB. American Journal of Transplantation, Vol. 4, Supplement 8.

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25. Daniel J. Moore, Beth P. Jarrett, Xiaolun Huang, Joseph W. Markmann, Major K. Lee IV, Moh Moh Lian, Meredith Chiaccio, Shaoping Deng, Andrew J. Caton, James F. Markmann. 2004. Induction of T-regs by intrathymic inoculation of antigen bearing splenocytes. American Journal of Transplantation, Vol. 4, Supplement 8.

26. Shaoping Deng, Mohammed Mohuiddin, Xiaolun Huang, Daniel J. Moore, Ergun Velidedeoglu, Moh Moh Lian, Major K. Lee IV, Haiying Chen, Robert Zhong, and James F. Markmann 2004. The role of B cells in anti-CD45RB induced transplantation tolerance. Transplantation. 78(2) Supplement 1:536-537.

27. Xiaolun Huang, Daniel J. Moore, Moh-Moh Lian, Haiying Chen, Major K. Lee, Thav Thambi-Pillai, Shaoping Deng, and James F. Markmann. 2005. Inhibition of ICAM-1, LFA-1 interaction prevents allograft tolerance induced by anti-CD45RB. Journal of the American College of Surgeons. 199 (3), S95-S96.

28. Paige Porrett, Major K. Lee, Daniel J. Moore, Moh-Moh Lian, Andrew Caton, and James F. Markmann. 2005. In vivo regulation of CD4 and CD8 T cells. American Journal of Transplantation. Vol.5. Supplement 11, pg 497.

29. Xiaolun Huang, Daniel J. Moore, Major K. Lee, Mohammad Mohiuddin, Ergun Velidedeoglu, Moh-Moh Lian, Shaoping Deng, and James F. Markmann. 2005. Signaling through GITR abrogates anti-CD45RB induced transplantation tolerance. American Journal of Transplantation. Vol.5. Supplement 11, pg 362.

30. Paige Porrett, Major K. Lee IV, Daniel J. Moore, Moh Moh Lian, Meredith Chiaccio, Birgitte Koeberlein, Andrew J. Caton, and James F. Markmann. 2005. T-regs inhibit effector T cell accumulation to prolong allograft survival Journal of the American College of Surgeons 201 (3): S90

31. Shaoping Deng, Xiaolun Huang, Daniel J. Moore, Mohammad Mohiuddin, Samsher Sonawane, James Kim, Moh-Moh Lian, Mark Schlomchik, and James Markmann. 2006. Interaction through co-stimulatory molecules but not antibody is required for B cell-dependent anti-CD45RB induced transplant tolerance. American Journal of Transplantation. Vol 6. Supplement 2: 308.

32. Daniel J. Moore, Josef Zienkiewicz, Peggy L. Kendall, Robert D. Collins, and Jacek Hawiger. 2007. Prevention of autoimmune diabetes by a nuclear import modulator. Pediatric Academic Societies/Lawson Wilkins Pediatric Endocrine Society Meeting. Winner SPR House Officer Research Prize/LWPES Presidential Poster Selection

33. Daniel J. Moore, Josef Zienkiewicz, Peggy L. Kendall, Antonio Digiandomenico, Danya Liu, Robert D. Collins, and Jacek Hawiger. 2007. Suppression of type 1 diabetes by nuclear import modulation. American Diabetes Association.

34. Daniela Buscariollo, Mario A. Davidson, Russell Rothman, William E. Russell, and Daniel J. Moore. 2009. Identification of factors that influence parental attitudes toward clinical research for type 1 diabetes. Hormone Research. Vol 72: 327-327

35. Analise B. Thomas, Sydney K. Elizer, and Daniel J. Moore. 2011. The Role of Hematopoietic Progenitor Cells in Immune Tolerance, Association of Women Surgeons/American College of Surgeons Joint Conference. Winner Starr Research Prize.

36. Gaoping Zhao, Daniel J. Moore, James I. Kim, Kang Mi Lee, Matthew R. O’Connor, Patrick E. Duff, Maozhu Yang, Ji Lei, James F. Markmann, Shaoping

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Deng. 2011. Endocrine Modulation Reverses Immune Senesscence and Restores Susceptibility to Transplantaiton Tolerance. American Journal of Transplantation. Vol 11: 437.

37. Pamela Krajewski, Sydney K. Elizer, Robert Dorrell, Jacek Hawiger, and Daniel J. Moore. 2011. Identifying Regulatory Cell Insufficiency in Type 1 Diabetes. Pediatric Academic Societies

38. Fang Yan, Lihong Wang, Ning Lu, Andrew F. Marshall, Daniel J. Moore, Liping Liu, D. Brent Polk. 2013. Tu1977 Colonization of Conventional Mice With Lactobacillus rhamnosus GG (LGG) Promotes Development of Protective Immune Responses. Gastroenterology 144 (5), S-895.

39. Gaoping Zhao, Daniel J. Moore, James Kim, Heidi Yeh, Kang Mi Lee, Matthew O'Connor, Maozhu Yang, Andrew Marshall, Lingling Wei, Christian Schuetz, Ji Lei, James Markmann, Shaoping Deng. 2013. Induction of species-specific tolerance to human islet xenografts by anti-CD45RB. Xenotransplantation. 20(5): 352-3.

40. Sarah Coggins, Daniel J. Moore, Danyvid Olivares-Villagomez, James Wynn, Joann Romano-Keeler, Pranathi Matta, Naoko Brown, Andrew Marshall, Akhil Maheshwair, Jeff Reese, and Jorn-Hendrik Weitkamp. 2014. Smad7 Drives Intestinal Immune Dysregulation after Chorioamnionitis. Pediatric Academic Societies, Vancouver, Canada.

41. James L. Wynn, Daniel J. Moore, Jin-Hua Liu, and Jacek Hawiger. 2014. IL-18 Increases Mortality in a Murine Model of Polymicrobial Sepsis. Pediatric Academic Societies, Vancouver, Canada.

42. Blair T Stocks, Chris S Wilson, Andrew F Marshall, and Daniel J Moore. 2014. Anti-CD3 Therapy Rescues Regulatory CD8 T Cell Deficiency in Type 1 Diabetes. Pediatric Academic Societies, Vancouver, Canada. Winner, SPR Student Research Award.

43. Hannah S. Steinberg, Daniel J. Moore, and Peggy L. Kendall. B Lymphocyte Signaling Governs Microbiome Selection and Type 1 Diabetes. 2014. The Microbiome in Diabetes Meeting.

44. Blair Stocks and Daniel J. Moore. 2015. CD8 T Regulatory Cells Attenuate Alloantibody Production and are Essential for Tolerance Induction to Islet Allografts. Cutting Edge of Transplantation Meeting. (Winner, AST Young Innovator Award)

45. Joann Romano-Keeler, Joseph Zackular, Daniel Moore, Christopher Hooper, Shufang Meng, Naoko Brown, John J Reese, and Joern-Hendrik Weitkamp. 2015 Fetal inheritance of the maternal microbiota prior to birth. Pediatric Academic Societes, San Diego, CA.

46. Melissa Garganta, Elaine Cochran, and Daniel J. Moore. 2015. Decreased Bone Mineral Density in a Child with a Novel Mutation of the Insulin Receptor (Rabson-Mendenhall Syndrome). Pediatric Academic Societes, San Diego, CA.

47. Stephen Owen, Preeti Chhabra, Christopher Wilson, Andrew Marshall, Rachel Bonami, Greg Poffenberger, Kenneth L. Brayman, and Daniel J. Moore. 2015. Innate human polyclonal IgM’s activate CD4 Tregs to prevent Type 1 diabetes. Pediatric Academic Societes, San Diego, CA. Winner, SPR Student Research Award

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48. Preeti Chhabra, Stephen Owen, Andrew F. Marshall, Christopher S. Wilson, Daniel T. Bowers, Linda Langman, Gregory L. Poffenberger, Rachel H. Bonami, Peter I. Lobo, Daniel J. Moore, and Kenneth L. Brayman. 2015. Deciphering the Mechanism of Islet Protective Immunity by Naturally-occurring Polyclonal IgM Immunotherapy. ADA Scientific Sessions.

49. Hannah E. Steinberg, Daniel J. Moore, and Peggy L. Kendall. 2015. B Lymphocyte Signaling Governs Microbiome Selection and Type 1 Diabetes. Immunology of Diabetes Society, Munich, Germany.

50. Chris S. Wilson, Blair T. Stocks, Andrew F. Marshall, James W. Thomas, Jonathan Irish, and Daniel J. Moore. 2015. Imatinib Therapy Targets B lymphocytes to Reverse Type 1 Diabetes. Immunology of Diabetes Society, Munich, Germany. (Winner, IDS Travel Award)

51. Blair T. Stocks, Christopher S. Wilson, Andrew F. Marshall, and Daniel J. Moore. 2015. IL-15 Immunotherapy Rescues Regulatory CD8 T Cell Deficiency in Type 1 Diabetes. Immunology of Diabetes Society, Munich, Germany.

52. Liping Liu, Yang Wang, Daniel J Moore, Andrew F Marshall, Sari Acra, D Brent Polk, Xiubao Ren, Fang Yan. 2015. Probiotic-Derived protein stimulates IgA production through regulation of APRIL and BAFF in Intestinal Epithelial Cells. Gastroenterology 148 (4), S-197.

53. William G. McMaster, Mohamed A. Saleh, Hana A. Itani, Allison E. Norlander, Cornelia M. Weyand, Meena Madhur, Daniel J. Moore, and David Harrison. 2015. Hypertension leads to end organ inflammation in humanized mice. Journal of the American Society of Hypertension 9 (4), e124.

54. James L. Wynn, Chris Wilson, Jacek Hawiger, Phil O. Scumpia, Jin-Hua Liu, Hector Wong, Patrick Lahni, John T. Benjamin, Erin Plosa, Jorn-Hendrik Weitkamp, Edward Sherwood, Lyle Moldawer, Richard Ungaro, Henry Baker, M. Lopez, Steven McElroy, and Daniel J. Moore. 2015. Il-18 Increases Murine Neonatal Sepsis Mortality via IL-17A. Shock 43 (6), 89-90.

Platform Presentations at Scientific Meetings 1. Shared T Cell Dysfunction in Multiple Models of Autoimmunity. 2001. American

Diabetes Association Scientific Sessions, San Antonio, Texas. 2. NOD mice are resistant to anti-CD45RB induced tolerance. 2002. American

Society of Transplant Surgeons/American Transplant Congress, Washington, DC. 3. Promotion of Tolerance in the Presence of NOD B Cells: A Role for B Cell-APC

Synergy. 2002. American Diabetes Association Scientific Sessions, Philadelphia, PA.

4. B cells function as a critical link in anti-CD45RB induced central tolerance. 2003. Transplantation Society Symposium, Keystone, CO.

5. Anti-CD45RB therapy induces thymus-dependent central tolerance in a TCR transgenic mouse transplant model. 2003. Transplantation Society Symposium, Keystone, CO.

6. Induction of T-regs by intrathymic inoculation of antigen bearing splenocytes. 2004. American Society of Transplant Surgeons/American Transplant Congress, Boston, MA.

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7. Comparative analysis of tolerance induction in NOD and NOR mice reveals a role for APC function in anti-CD45RB induced tolerance. 2004. American Society of Transplant Surgeons/American Transplant Congress, Boston, MA.

8. Prevention of autoimmune diabetes by a nuclear import modulator. 2007. Pediatric Academic Societies/ Lawson Wilkins Pediatric Endocrine Society Meeting, Toronto, CA.

9. Suppression of autoimmune diabetes by targeting nuclear import of pro-inflammatory transcription factors. 2007. American Diabetes Association Scientific Sessions, Chicago, IL.

10. Identifying Regulatory Cell Insufficiency in Type 1 Diabetes. 2011 Pediatric Academic Societies, Denver, CO. (Presentation by medical student Pamela Krajewski, SPR Travel Award Winner).

11. Disrupted Hematopoietic Stem Cell Mobilization Prevents Transplantation Tolerance. American College of Surgeons, Chicago, IL, 2012. (Presentation by medical student Analise Thomas, Winner 3rd Prize Basic Science Competition)

12. Anti-CD3 Therapy Rescues Regulatory CD8 T Cell Deficiency in Type 1 Diabetes. Pediatric Academic Societies, Vancouver, Canada, 2014. (Presentation by MSTP dissertation student Blair Stocks, Winner of SPR Student Research Prize).

13. CD8 T Regulatory Cells Attenuate Alloantibody Production and are Essential for Tolerance Induction to Islet Allografts. 2015. Cutting Edge of Transplantation Meeting. (Presentation by MSTP student Blair Stocks, Young Innovator Award Winner).

14. Imatinib Therapy Targets B lymphocytes to Reverse Type 1 Diabetes. 2015. (Presentation by IGP dissertation student Chris Wilson at the Immunology of Diabetes Society, Munich, Germany, IDS Travel Award Winner).

15. Innate human polyclonal IgM’s activate CD4 Tregs to prevent Type 1 diabetes. 2015. (Presentation by undergraduate student Stephen Owen at Pediatric Academic Societies, San Diego, CA) (Winner, SPR Student Research Award)