date prepared august 28, 2015...date prepared august 28, 2015 name gregory m. miller ph.d. office...

Date Prepared August 28, 2015

Name Gregory M. Miller Ph.D.

Office Address Northeastern University

Bouve College of Health Sciences

Department of Pharmaceutical Sciences and Center for Drug Discovery

Mugar Hall Room 338

360 Huntington Ave., Boston, MA 02115

Home Address 21 Curtiss Circle, Sudbury, MA 01772

Work Phone (617)-373-6985

Cell Phone (508) 930-8027

Work Email [email protected]

Work FAX (617)-373-6985

Place of Birth Bronx, New York

Education

1986 B.A. Psychology Ithaca College, NY

1991 M.A. Psychology-

Neuropsychology

Queens College, City University of

New York

1993 Ph.D. Biomedical Sciences Mount Sinai School of Medicine, City

University of New York

Postdoctoral Training

09/93-01/94 Research Fellow

in Medicine, Division

of Endocrinology and

Metabolism

Neuroendocrinology

and Neurobiology of

Reproduction

Mount Sinai School

of Medicine,

New York, NY

01/94-01/97

Research Fellow in

Medicine,

Neuroendocrine Unit

Neuroendocrinology

and Pituitary Tumor

Biology

Massachusetts

General Hospital and

HMS, Boston, MA

01/10 Responsible Conduct of Research (RCR) HMS, Boston, MA

03/13 PRIM&R, Public Responsibility in Medicine Baltimore, MD

and Research; IACUC 101 Training and

IACUC Research Animal Oversight

mailto:[email protected]

2

Faculty Academic Appointments

01/97-05/97 Instructor Medicine Harvard Medical School

05/97-12/04 Instructor Psychiatry Harvard Medical School

01/05- 07/12

07/12- 08/14

Assistant Professor

Associate Professor

Psychiatry

Psychiatry

Harvard Medical School


08/14 – Associate Professor Pharmaceutical Sciences Northeastern University

08/14 – Associate Scientist Center for Drug Discovery Northeastern University

08/14- 06/16 Visiting Assoc. Prof. Psychiatry Harvard Medical School

Appointments at Hospitals/Affiliated Institution

1/95 – 5/97 Assistant in

Biochemistry

Neuroendocrine Unit,

Medicine

Massachusetts General Hospital,

Boston, Massachusetts

9/14 – 6/16 Visiting Scientist Dept. of Psychiatry Beth Israel Deaconess Medical Center

Major Administrative Leadership Positions

1997-2005 Division Manager

Division of Neurochemistry

New England Primate Research

Center, Harvard Medical School

2006-2008 Acting Chair, Division of Neurochemistry New England Primate Research


2006-2014 Director, Primate Genetics Core New England Primate Research


2007-2011 Director of Research and Compliance

Mouse Behavioral Laboratory



2012-2014 Director, Summer Undergraduate and

Summer Veterinary Training Programs



Professional Service – Academic

2009 Member, Renovation Committee New England Primate Research


2010/2011

Chair, Search Committee - Genetics Faculty New England Primate Research


2012 Member, Animal Records Information

Technology Team



3

Professional Service – Academic, cont.

2013 Appointed - NEPRC IACUC New England Primate Research


2015 Honors Education Inquiry Group Northeastern University

2015 Graduate Student Committee

Department of Pharmaceutical Sciences

Northeastern University

2015 Department Chair Search Committee



2015 Ph.D. Qualifying Exams



2015 Ph.D. Thesis Proposal Defenses



2015 Faculty Mentor for NU Masters Students



2015 Capstone Project Supervisor



Professional Service, National and International

2007-2014 Genomic Banking Consortium National Center for Research Resources

2007-2014 Genetics Consortium National Center for Research Resources

2008-2009 Member, Publications Committee College on Problem of Drug Addiction

2009-2012 Chair, Publications Committee College on Problem of Drug Addiction

2012-2016 Board Member, Board of Directors College on Problem of Drug Addiction

2012-2014 Nominations Committee College on Problem of Drug Addiction

2014- Senior Oversight, Pub. Committee College on Problem of Drug Addiction

Membership in Professional Societies

1992- Society for Neuroscience Member

2001- College on Problems of Drug Dependence Member

2005- Research Society on Alcoholism Member

2006- International Society of Psychiatric Genetics Member

2007- American Society for Pharmacology and Experimental Therapeutics Member

2013- Public Responsibility in Medicine and Research (PRIM&R) Member

4

Grant/Center Review Activities

2007 Grant Reviewer

October, 2007

Neurological Foundation of New

Zealand

2007-2008 The Mount Sinai Center for Personalized

Medicine Review Panel

Andrea and Charles Bronfman

Philanthropies, New York, NY

October, 2007 Center Reviewer

June, 2008 Center Reviewer

2008 Grant Reviewer

February, 2008

National Science Foundation, The

Hague, the Netherlands

2008 Grant Reviewer Netherlands Genomic Initiative

May, 2008 Ad hoc Reviewer

2008-2010 Grant Reviewer NSF

September, 2008 Ad hoc Reviewer

October, 2009 Ad hoc Reviewer

September, 2010 Ad hoc Reviewer

2009 B/START study Section NIDA/ NIH

March, 2009 Ad hoc Reviewer

2010 ZDA1 GXM-A (09) 1

March, 2010

NIDA/ NIH

Ad hoc Reviewer

2011 INIA WEST NIAAA/NIH

May, 2011 Reviewer

2011 INIA STRESS NIAAA/NIH

June, 2011 Reviewer

2011 ZAA1 GG (21) Ad hoc Reviewer

July, 2011 NIAAA/NIH

2012 Grant Reviewer Health Research Council of

February, 2012 New Zealand

2012 Harvard Catalyst Harvard Medical School

April, 2012 Reviewer

2013 ZRG1 NMB-A (02) S CSR

NIH Study Section

May/June, 2013

2013 Grant Reviewer The Leverhulme Trust

Visiting Professorship Grant London, UK

2014 ZRG1 MDCN-B(05) CSR

NIH Study Section

2015 ZRG1 MDCN-B(05) CSR

NIH Study Section

5

Editorial Activities (2007-)

2007, 2010, 2011 BMC Genomics

2007 American Journal of Primatology

2007, 2008, 2010 Molecular Psychiatry

2007 PNAS

2008 Archives of General Psychiatry

2008, 2009 Bioorganic and Medicinal Chemistry

2008 Journal of Molecular Biology

2008 Pharmacological Review

2008 BMC Neuroscience

2009 Journal of Lipid Research

2009 Molecular Pharmacology

2009 Biochemical Pharmacology

2010 Neuropharmacology

2010 Psychoneuroendocrinology

2010 Journal of Neural Transmission

2010 Human Genetics

2011 Schizophrenia Research

2011 Neuroscience & Biobehavioral Reviews

2011 Journal of Neuroimmune Pharmacology

2011 Psychopharmacology

2012, 2015 Neuropsychopharmacology

2012 Chemical Biology & Drug Design

2012 Progress in Neuro-Psychopharmacology & Biological Psychiatry

2012 Genes, Brain and Behavior

2012 Journal of Neurochemistry

2012 Journal of Medical Primatology

2012 Synapse

2013 Translational Developmental Psychiatry

2013 Pharmacogenetics and Genomics

2014 Journal of Pharmacology and Experimental Therapeutics

2014 International Journal of Neuropsychopharmacology

2014 Physiology and Behavior

2015 Scientific Reports/Nature Publishing Group

6

Other Editorial Roles

2009 Issue Editor, Genetic Tools for

Understanding the Primate Genome

Methods

2009-2012 Editor, News and Views Section Drug and Alcohol

Dependence

Awarded NIH Grants

1991-1994 Endocrinology Training Grant

NIDDK/ T32DK07645

Graduate Trainee

Terry Davies, MD (PI)

1994-1995 Endocrine Training Grant

NIDDK/ P32DK07028

Postdoctoral Trainee

Anne Klibanski, MD (PI)

1996-1997 Somatostatin Receptors in Pituitary Tumors

NIDDK/ NRSA F32DK09281

PI

1997-2006 Evaluation of novel cocaine medications

NIDA/R01 11558

Co-I; PI Bertha K. Madras

1998-2008 Molecular probes for cocaine recognition sites

NIDA/ R01 06303 (Merit Award to Bertha K. Madras)

Co-I (1998-2006); PI Bertha K. Madras

Managing PI (2006-2008; $731,859)

To explore neurochemistry of psychostimulant drugs of abuse and

therapeutics that target the brain monoamine transporters.

2004-2014 P51OD011103

(NEPRC Base grant)

NIH/OD/ORIP

Core Scientist; Jeffrey Flier PI

New England Primate Research Center Base Grant

Institutional support

2004-2010 Trace amine receptors in nonhuman primates

NIDA/ R01 016606

PI ($1,160,534)

To explore a newly-identified receptor family in primate brain.

7

Awarded NIH Grants, cont.

2006-2009 A monkey model of human mu-opioid receptor physiogenetics

NIDA/ R21 021180

PI ($457,399)

To explore comparable functionality of rhesus and human opioid receptor

polymorphisms.

2007-2010 Alcohol abuse pharmacogenomics: building naturalistic rhesus monkey

models

NIAAA/ R21 016194

PI ($443,823)

To assess novel polymorphisms and explore genotype/phenotype relationships

in rhesus monkeys related to human alcoholism.

2007-2010 Methamphetamine effects via Trace Amine Associated Receptor 1

NIDA/R21 022323

PI ($472,788)

To assess Trace Amine Associated Receptor 1 functionality with regard to mechanisms

of methamphetamine action in brain.

2008-2011 Neurogenetics of serotonin regulation: building naturalistic rhesus monkey

Models

NIMH/ R21 077995

PI ($429,413)

To assess neurogenetic effects of polymorphisms in serotonergic genes.

2009-2011 TAAR1 polymorphisms in rhesus monkeys

NIDA/ R03 025802

PI ($173,500)

To identify and characterize Trace Amine Associated Receptor 1 genetic

variants in rhesus monkeys and humans.

2009-2010 Alcohol abuse pharmacogenomics: building naturalistic rhesus monkey

Models

NIAAA/ R21 Supplement 016194-02S1

PI ($111,749)

To continue the productive research assessing novel polymorphisms and

exploring genotype/phenotype relationships in rhesus monkeys related to

human alcoholism.

https://commons.era.nih.gov/commons/genericStatus.do?actionRole=nonPI&applID=7941634&uhf-token=rlwIpAPFi%2Bq6rmgWq0tXKx9Uqno%3D

8

Awarded NIH Grants, cont.

2009 Methamphetamine Effects via Trace Amine Associated Receptor 1

NIDA/ R21 Supplement 022323-02S1

PI ($11,267)

To fund a summer student, Kate Sullivan, to work on a project using Trace

Amine Associated Receptor 1 Knockout Mice.

2009-2014 Drug Abuse-related Neurobiology and Genetic Variance Modeled in

Rhesus Monkeys

NIDA/ K02 025697

PI ($615,275)

Independent Scientist Award (for salary support/career development)

2009-2014 Opioid Receptor Polymorphisms and Nonhuman Primate Models of Alcohol

Abuse

NIAAA/ R01 016828

Co-I; Donna Platt PI ($2.060,315)

To assess a novel polymorphism and explore naltrexone pharmacogenomics

in rhesus monkeys related to human alcoholism.

*This grant succeeds R21 021180 (GMM-PI)

2012-2014 Naltrexone and AIDS progression

NIDA/ 1R21DA034420

PI ($437,500.00)

To investigate Low Dose Naltrexone as a novel therapeutic intervention for

HIV using previously SIV-infected rhesus macaques.

2010-2015 Epigenetic Regulation of Serotonin: Relevance to HIV and Methamphetamine

Abuse

NIDA/ R21 030177 (3 yr RFP)

PI ($947,744 )

To investigate epigenetic mechanisms of serotonergic genes in normal and

SIV-infected rhesus monkeys.

2010-2015

Functional genetic evolution of human brain behavior

NIAAA/ 5R01AA19688

Co-I; Eric Vallender PI ($1,956,412)

To investigate functional polymorphisms in rhesus monkeys

9

Competitive Institutional Awards

2005-2007 NEPRC New Lab Start-up Package/ Promotion to Assistant Professor

New England Primate Research Center, Harvard Medical School

PI (two years of salary plus $50,000/year for two years)

To establish an independent laboratory at NEPRC.

2007-2009 Naturalistic modeling of alcoholism genotype/ phenotype relationships and

naltrexone pharmacogenomics in rhesus monkeys

NEPRC Pilot Project (competitive)

PI ($80,000 Direct Cost)

To establish a pharmacogenomic preclinical platform using rhesus monkeys

for medications development for alcoholism.

2009-2011 Development of a cognitive biomarker for alcoholism

NEPRC Pilot Project (competitive)

Originator, Co-I; Donna Platt PI ($100,000 Direct Cost)

Identify biomarkers of cognitive function in genetically-characterized alcohol-

drinking rhesus monkeys prior to and after alcohol exposure.

2010-2011 A marmoset model of methamphetamine-induced cognitive, motor and

neurological effects

NEPRC Pilot Project (competitive) PI ($40,000 Direct Cost)

To investigate behavioral effects of methamphetamine mediated by Trace

Amine Associated Receptor 1.

2015- Unrestricted Faculty Research Funds

PI ($187,000)

These funds were gifted to me from Harvard University and were transferred

to Northeastern University for my professional use.

Funding of Student Mentees

2006 Irene and Eric Simon Brain Research Foundation Summer

Fellowship to fund Liz Calder, undergraduate student

“A monkey model of mu-opioid receptor physiogenetics”

2007-2012 Supervision and training of one undergraduate summer student each year funded

through the Department of Psychology University of Massachusetts, Amherst MA

2009 NIH R21 Supplement 022323-02S1

Funding for Kate Sullivan, undergraduate student

“Methamphetamine Effects via Trace Amine Associated Receptor 1”

10

Funding of Student Mentees, cont.

2011 College on Problems of Drug Dependence Travel Award

NIDA Mini-convention - Frontiers in Addiction Research

Kiran Akila, foreign student from India

2015 Northeastern University Provost Undergraduate Research and Creative Endeavors

Award to fund Paige Dickson, undergraduate student

“Elucidation of the chemically-induced methamphetamine immune response and

its potential mediation by a receptor target, Trace Amine Associated Receptor 1"

Addiction Sciences Lab, Miller PI, Northeastern University ($2,625)

2015 Northeastern University

Undergraduate Honors Program Early Research Assistantship, Inaugural.

Only faculty member awarded two awards

Selected students: Nina L Tamashunas, Kevin S Freeman

Addiction Sciences Lab, Miller PI, Northeastern University ($1000 each)

2015 Northeastern University Scholars Independent Research Fellowships (SIRFs)

To fund two Honors Scholars Students under my mentorship

Jared Ontko and Cindy Wu

"Central and microbiomic circadian disruptions during finals week: How

biological clocks in the gut and brain interact to effect cognitive performance

during diet change and sleep deprivation.” ($10,000)

2015 Northeastern University Scholars Independent Research Fellowships (SIRFs)

To fund two Honors Scholars Students under my mentorship

Kristen Brown and Christine Boutros

"Exploring co-use of marijuana and alcohol (“crossfading”): order effects of

marijuana constituents on ethanol self-administration in a mouse model."

($10,000)

2015 Northeastern University

Undergraduate Honors Program Early Research Assistantship, Summer 2015.

Two awards

Selected students: Nicholas Mortillaro, Lauren Abbott($1000 each)

2015 Nu Rho Psi Undergraduate Research Grant – 1 of 2 National Awards -

Kristen Brown, Sophomore, Honors Scholars Undergraduate, Behavioral

Neuroscience; and Christine Boutros, Sophomore, Honors Scholars Undergraduate,

Behavioral Neuroscience

"Exploring co-use of marijuana and alcohol (“crossfading”): order effects of

marijuana constituents on ethanol self-administration in a mouse model"

($400)

11

Unfunded and/or In Submission NIH Grants

2014 2R01DA011558-10A1 (MPI)

Novel psychostimulant drugs of abuse: behavior, biology, pathology.

Miller PI; Madras PI

Impact Score: 44, Percentile Score: 46.0

2014 1R21DA036708-01

Immunological actions of methamphetamine via trace amine associated receptor 1

Miller-PI

Impact Score: 58

2014 1R01AA021189-01A1

Trace amine associated receptor 1 in alcohol behaviors and treatments

Miller-PI

Impact Score: 49

2014 TAAR1-Cannabinoid Receptor Signaling Interactions in Drug Abuse

R21 submission 10/16/14 not discussed

Resubmitted 5/15

2015 Alternative REST Splicing and Neural Gene Expression

R21 submission 2/19/15 not discussed

2015 Alternative Splicing of REST in Neuroepigenetics

R01 submission 6/3/15

Teaching and Training

Teaching of Students in Courses

1988, 1989 Psychology 101

Undergraduate

City University of New York

1998 Substance Abuse: Addictive Process

ABS PS 521 M.O.

4th year medical students


2014 PHSC6300 11556 Pharmaceutical Science

Seminar SEC 01 - Fall 2014

Graduate


12

Teaching of Students in Courses, cont.


Research SEC 05 - Fall 2014

Graduate



Seminar SEC 01 - Spring 2015

Graduate



Research SEC 03 - Spring 2015

Graduate


2015 PMCL6261 36820 Pharmacology 2 SEC 01 -

Spring 2015

Graduate


2015 PHSC4502 50013 Pharmacology/Med

Chemistry 2 SEC 01 - Summer Full 2015

Undergraduate


2015 PHSC 4501 – Pharmacology/Medicinal

Chemistry 1 SEC 01 – Fall 2015

Undergraduate


Teaching of Students (Assistantships, Lecture Series)

1991-1992 Neuroendocrinology

Arthur M. Fishberg Center for

Neurobiology

Mount Sinai School of Medicine, New York,

NY

2003, 2005 Cell Biology of Addiction

Cold Spring Harbor

Course Assistant

2008 Beth Israel Deaconess Medical

Center Psychiatry Residents

training in Neuroscience

Department of Psychiatry

Residents

Initiated and organized NEPRC tour and lecture

series presented by NEPRC Neuroscience

faculty. Presented 1 lecture: Comparable

Functional Polymorphisms in Rhesus Monkey

and Human Neuropsychiatric Genes

https://blackboard.neu.edu/webapps/blackboard/execute/launcher?type=Course&id=_2428806_1&url=








13

Teaching in Continuing Medical Education Courses

1997 Neurobiology of Addiction Boston, MA

CME: Treating the Addictions

Cambridge Health Alliance and Department of

Psychiatry, Harvard Medical School

2008 The Neurobiology and Genetic Susceptibility of

Addiction

Boston, MA

CME: Treating the Addictions.

Cambridge Health Alliance and Department of

Psychiatry, Harvard Medical School

Ratings by 661 Attendees (mean):

Teaching ability: 3.56/4

Level of Knowledge: 3.84/4

The objective was met: 3.55/4

New Concepts Learned: 3.56/4

Training and Mentorship in Research

Mentoring of Postdoctoral Research Associates

From 1996-2005, I had the opportunity to mentor postdoctoral research associates working under my

supervisory assignment:

1996-1997 Mentoring of an Endocrinology Resident:

Joseph Pinzone, MD

Neuroendocrine Unit, MGH

Daily mentorship, 1 year

1997-1998 Mentoring and training of an Assistant Professor:

Larry Gracz, PhD

Division of Neurochemistry, NEPRC

Daily mentorship, two

consecutive summers

1997-2005 Mentoring of Postdoctoral Fellows:

Richard De La Graza, PhD

Martin Goulet, PhD

Jeffrey Brown, PhD

Servet Yatin, PhD

Danqing Xiao, PhD

Christopher Vericco, PhD

Amy Jassen, PhD

Over 8 years in the

Division of

Neurochemistry and

Instructor in Psychiatry, I

mentored seven

postdoctoral fellows; daily

mentorship. All seven

have co-published

manuscripts with me.

14

Mentoring of Postdoctoral Research Associates, cont.

Mentored postdoctoral research associates funded under my NIH grants:

2005-2013 Guo-lin Chen, Ph.D.

Research Assistant Professor, Department of Pharmaceutical science and Center

for Drug Discovery, Northeastern University

Instructor in Psychiatry (promoted 12/13) Division of Neuroscience, NEPRC,

HMS; Postdoctoral Fellow, Miller Lab, NEPRC 2005-2013

15 publications in my lab/ 10 are first authorship

Co-I and major contributor; R21 DA030177 Epigenetic Regulation of Serotonin:

Relevance to HIV and Methamphetamine Abuse, 6/10-2/14

Winner of Best Paper in Neuroscience at NEPRC - 2012 Winner of the 3rdt

Annual Roger T. Kelleher Award for Excellence in Neuroscience and Behavior

for: Chen G-L and Miller GM. Advances in Tryptophan Hydroxylase-2 Gene

Expression Regulation: New Insights into Serotonin-Stress Interaction and

Clinical Implications. American Journal of Medical Genetics Part B:

Neuropsychiatric Genetics. Mar;159B(2):2012, 152-71.

2005-2012 Zhihua Xie, Ph.D.

Independent Consultant, Biobanking Strategies

Research Associate, Division of Neuroscience, NEPRC

Postdoctoral Fellow, Miller Lab, NEPRC 2005-2009

11 publications in my lab/ 7 are first authorship

Best paper in Neuroscience at NEPRC: 2010 Winner of the 1st Annual Roger T.

Kelleher Award for Excellence in Neuroscience and Behavior for: Xie Z and

Miller GM. A Receptor Mechanism for Methamphetamine Action in Dopamine

Transporter Regulation in Brain. J. Pharmacol. Exp. Ther. 2009;330(1):316-25.

2006-2009

Eric J. Vallender, Ph.D.

Associate Professor, University of Mississippi Medical Center, 2015

Assistant Professor in Psychiatry 2012, Division of Neuroscience, NEPRC, HMS

Postdoctoral Fellow, Miller Lab, NEPRC 2005-2009

Instructor, Miller Lab, NEPRC 2009-2012

Promotion to Assistant Professor 6/12, Harvard Medical School

>20 publications 2005-2013; Awarded NRSA MH082507, Modeling the

Neurogenetics of Serotonin Regulation Awarded R01 AA019688 Functional

Genetic Evolution of Human Brain and Behavior, 8/10-7/15

Vallender-PI; Miller Co-I

Selected as an NEPRC “Super-Instructor” following a national search and given an

extensive laboratory start-up package

15

Mentoring of Postdoctoral Research Associates, cont.

2009-2010 Spencer Lynn, Ph.D.

Research Assistant Professor,

Northeastern University, Dept. Psychology

1 publication in my lab

Awarded R01 MH093394-01 The Utility of Threat Detection in Generalized Social

Anxiety Disorder: Score 14, percentile 6.0

Mentoring of Post-Bachelorette Research Technicians

Reflects my strong commitment to the academic advancement of post-bachelorette young adults who

were hired as research technicians in my lab.

Jacob Bendor, PhD Postdoctoral Fellow, UCSF Neurology

Trained at Rockefeller University with Paul Greengard

Summer student in my lab 2001 and 2002; Research Technician I in my lab 2003 and 2004

Publication: Miller GM, Bendor J, Tiefenbacher S, Yang H, Novak M, Madras BK. A Mu-opioid

receptor single nucleotide polymorphism in rhesus monkey: Association with stress response and

aggression. Molecular Psychiatry 2004; 9(1):99-108.

Sara Hakim Graduate Student, The Albert Einstein College of Medicine

Summer student in my lab 2005 and 2006; Research Technician I in my lab 2007 and 2008

Publications: Chen GL, Novak MA, Hakim S, Xie Z, Miller GM. Tryptophan hydroxylase-2 gene

polymorphisms in rhesus monkeys: association with hypothalamic-pituitary-adrenal axis function

and in vitro gene expression. Molecular Psychiatry, 2006;11(10):914-28; Vallender EJ, Priddy CM,

Hakim S, Yang H, Chen G-L, Miller GM. Functional variation in the 3’ UTR of the serotonin

transporter in human and rhesus macaque. Genes, Brain and Behavior 2008;7(6):690-7.

Cassandra Priddy Graduate Student, Carnegie Mellon University

Research Technician I 2006-2007; Research Technician II 2007-2008

Publications: Vallender EJ, Priddy CM, Chen G-L, Miller GM. Human Expression Variation in the

mu Opioid Receptor is Paralleled in the Rhesus Macaque. Behavior Genetics, 2008;38(4):390-395;

Vallender EJ, Priddy CM, Hakim S, Yang H, Chen G-L, Miller GM. Functional variation in the 3’

UTR of the serotonin transporter in human and rhesus macaque. Genes, Brain and Behavior

2008;7(6):690-7.

Caroline Sweeney Graduate Student University of Massachusetts

Research Technician 2011-2013

Lisa Ogawa Graduate student, Yale University

Research Technician 2012-2014

Publication: Large-scale polymorphism discovery in macaque G-protein coupled receptors. BMC

Genomics. 2013 Oct 11;14:703.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16847459&query_hl=1&itool=pubmed_docsum

http://carnegie-mellon.academia.edu/

http://www.ncbi.nlm.nih.gov/pubmed/24119066

16

Mentoring of Undergraduate Students

1997-2005 Supervision and training of undergraduate summer

students in the Division of Neurochemistry

New England Primate Research Center Summer

Undergraduate Training Program (SUTP)

Over 8 years, I supervised

2-4 students per summer.

2005-2013 Supervision and training of undergraduate summer

students in my lab

New England Primate Research Center Summer

Undergraduate Training Program (SUTP)

>30 undergraduate

summer students trained in

my lab over this period,

averaging 6-7/summer

2014-2015 Originated a research mentorship program for undergraduate students

Program overview: I initiated a “skunkworks” educational program on my own initiative and time,

born out of my interest in recruiting students into biomedical research. Students were first taken

through EH&S training and introduced to how to search the biomedical literature and use library

resources. After studying and commenting on three review papers that I had written on one of the

receptors that we study, students were granted access to a community database of electronic folders

containing scientific literature by topic – centered on the concepts they were introduced to in the

reviews - as a guide to help them develop their interests. Students were invited to add relevant

literature to any folder, or to create their own folder. Students were assisted in gravitating towards an

interest focus and in partnering with others who share a similar interest. The process created several

“think tanks” where collaborative ideas got generated, fostered by Journal Club-like meetings in the

evenings in Snell library, which students attended and participated in voluntarily. In doing so students

built enthusiasm, comradery and a team mentality. Throughout this process, students followed a

“graphic syllabus” that I created which instructs on how one goes about getting involved in scientific

research of highest impact and meaning. Concurrent with these activities, students were introduced to

working in the lab. Each student learned basic cell culture and many learned basic molecular biology

skills. In addition to learning the specific laboratory techniques, students were exposed to a spectrum

of knowledge and skills related to productive lab work, research methods, data presentation, ethics and

personal integrity. Most notably, students learned how to work collaboratively together, developed

laboratory skills and were introduced to issues related to the use of animal models in biomedical

research.

Outcomes:

Students fulfilled all EH&S requirements

Students were mentored in hypothesis generation and study design

Students were taught laboratory techniques and methodologies

Students were introduced to Research Ethics and a related mandate - a focus on animal research

ethics was used to teach skills related to defending personal opinions with facts

Students ran journal clubs at night that introduced the structure of the scientific manuscript and

the research grant, as well as manuscript reviews related to their proposed projects

Students recruited others into their team who were interested in the topic they were covering

Students developed a long-term mentor/mentee relationship

See “Funding of Student Mentees” above.

See graphic syllabus

http://www.northeastern.edu/bouve/assets/uploads/2014/10/Graphic-Syllabus-for-students.pdf



17

Local, Regional, National and International Invited Scientific Presentations

Presentation within my local institution

2000 Molecular Approaches to Attention Deficit Hyperactivity Disorder

NEPRC Summer Internship Program

New England Primate Research Center, Southborough, MA

2002 Genes and Drug Addiction



2002 Point mutations of the human dopamine transporter reveal differential binding of an

amine and a nonamine ligand

Neuroscience Seminar Series

McLean Hospital, Belmont, MA

2003 Genetic Diversity of Drug Targets in the Brain



2004 Genetic Variations and Phenotypic Associations Common to Rhesus Monkeys and

Humans

New Faculty Search Seminar


2005 Rhesus Monkey Models in Neurobiology, Neuropsychiatry and AIDS

Boston University-NEPRC symposium


2005 Naturalistic Modeling of Human Functional Polymorphisms in Rhesus Monkeys

Research Symposium


2008 What are the Roles of Trace Amine-Associated Receptor 1 in Primates?

Division of Behavioral Biology, NEPRC


2008 Trace Amine Receptor 1 in Brain Monoaminergic Systems

Division of Comparative Pathology


2008 Trace Amine Associated Receptor 1 in Brain Monoaminergic Systems



18

2008 The Neurobiology and Genetic Susceptibility of Addiction



2008 Comparable Functional Polymorphisms in Rhesus Monkey and Human

Neuropsychiatric Genes

The Behavioral Genetics Laboratory


2011 Drug addiction research at the New England Primate Research Center

Division of Primate Resources Animal Care Staff


2011 The Biogenic Amine/Amphetamine Receptor TAAR1: What’s It Doing in Brain

Monoaminergic Systems?



2013

Models of polygenetic psychiatric and addictive disorders

Grand Rounds

Center for Addiction Medicine

Massachusetts General Hospital, Boston, MA

Regional

2008 Trace Amine-Associated Receptor 1 in Brain Monoaminergic Systems

Invited Speaker, Boston University Medical School, Boston, MA

2009 The Neurobiology and Genetic Susceptibility of Addiction

Invited Speaker

Summer Undergraduate Research Fellowship (SURF) Program Seminar Series

The Massachusetts College of Pharmacy and Health Sciences, Boston, MA

2010 The Role of TAAR1 in Monoamine Transporter Regulation and Methamphetamine

Action

Invited Speaker, Center for Drug Discovery Annual Symposium

Northeastern University, Boston, MA

2013 Trace Amine Associated Receptor 1 in the Monoamine System and its Role in

Modulating the Effects of Drugs of Abuse

Invited Speaker, Department of Pharmaceutical Sciences

Bouvé College of Health Sciences


2014 TAAR1 and Drugs of Abuse

Invited Speaker, Center for Drug Discovery Annual Symposium


19

National

1999 Point mutations in the human dopamine transporter reveal differential binding of

an amine and a non-amine ligand

Oral presentation/ selected abstract

Society for Neuroscience Annual Meeting, Miami Beach, Florida

2000 Single Nucleotide Polymorphisms Distinguish Multiple Dopamine Transporter

Alleles in Primates: Implications for Association With ADHD and Other

Neuropsychiatric Disorders


Society for Neuroscience Annual Meeting, New Orleans, Louisiana

2001 Genetic Diversity of Drug Targets in the Brain: Relevance to Drug Response?,


College on Problems of Drug Dependence Annual Meeting, Scottsdale, Arizona.

2001

Single Nucleotide Polymorphisms Distinguish Multiple Dopamine Transporter

Alleles in Primates

Cold Spring Harbor Laboratory

Cold Spring Harbor, NY

2002 Cloning of rhesus monkey TAR-1, a novel GPCR for “trace” amines


Society for Neuroscience Annual Meeting, Orlando, Florida

2003 A Mu-opioid Receptor Single Nucleotide Polymorphism in Rhesus Monkey:

Association With Stress Response And Aggression


Society for Neuroscience Annual Meeting, New Orleans, Louisiana

2003 Genetic Variations And Phenotypic Associations Common To Rhesus Monkeys

And Humans

Invited Presentations

Cell Biology of Addiction Course

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

2006 Rhesus monkey Trace Amine Receptor 1

Invited Presentation

Lundbeck Research USA Inc., Mahwah, NJ

2006

Neurobiology and Physiogenetics of Neuropsychiatric


NCRR Workshops on the Rhesus Monkey Genome, NIH, Bethesda, MD

2006

Trace amine receptor 1 in Brain Monoaminergic Systems


Eli Lilly, Indianapolis, IN

20

2007 Using non-human primates to model the genetics of human neuropsychiatric

Disorders


NCRR Workshops on the Rhesus Monkey Genome, NIH, Bethesda, MD

2008

Developing Non-Human Primate Genetic Models of Human Neuropsychiatric and

Addictive Disease


Society for Neuroscience Annual Meeting, Washington, DC

2008 Session 314.Stress, depression and monoamines

Session Chair

Society for Neuroscience Annual Meeting, Washington, DC

2008 What are the Roles of Trace Amine Associated Receptor 1 in Primates?

Session Organizer and Invited Presentation

The 41st Winter Conference on Brain Research, Snowbird, UT

2008 Trace Amine-Associated Receptor 1 in Brain Monoaminergic Systems

Selected by the Department of Physiology & Pharmacology Graduate Students as

the annual invited speaker

Oregon Health & Science University

Portland, OR

2008 Monkey Genes Come in Human Flavors: Translational Models of Human

Neuropsychiatric and Substance Abuse Disorders in Rhesus Monkeys

Invited by the APA Committee on Animal Research and Ethics

The 116th Annual Meeting of the American Psychological Association

Boston, MA

2009 Non-Human Primate Genetic Models of Human Neuropsychiatric and Addictive

Disease. The Behavioral Genetics of Co-Morbidity: More Than Just

Overlapping Phenotypes

Invited NIDA-sponsored Presentation

The 42st Winter Conference on Brain Research

Copper Mountain, CO

2009 Trace Amine-Associated Receptor 1 (TAAR1) as a Monoaminergic Modulator


Oregon National Primate Research Center, Beaverton, OR

2010 Oral Communications Session 16. Transmitting Information on Serotonin

Session Chair

College on Problems of Drug Dependence Annual Meeting

Scottsdale, Arizona.

21

2011

Advancing the Rhesus Monkey Model for Opioid Research: Discovery of a Novel

Nonsynonymous Variant in the Kappa Opioid Receptor Gene



Hollywood, Florida

2011 Oral Communications 2 Genetics: Code Read

Session Chair


Hollywood, Florida

2011 The Biogenic Amine/Amphetamine Receptor TAAR1: What’s It Doing in Brain

Monoaminergic Systems?


Department of Physiology

Emory School of Medicine, Atlanta, GA

2013 Trace Amine Associated Receptor 1 in the Monoamine System and its Role in

Modulating the Effects of Drugs of Abuse.


Dept. Integrative Physiology and Neuroscience

College of Veterinary Medicine

Washington State University, Pullman, WA

2013

Studies on Trace Amine Associated Receptor 1


TMED - Translational Medicine & Early Development

Sunovion Pharmaceuticals Inc.

Marlborough, MA

2013 Trace amine-associated receptor 1 is a methamphetamine receptor that

differentially controls DAT and NET internalization


Symposium XIII: New Tools Provide New Insights Into Methamphetamine’s

Actions


San Diego, CA

2013 Trace amine associated receptor 1 modulation of the rewarding and

immunological effects of drugs of abuse supports its relevance as a therapeutic

target.

Invited Speaker

Session Chair

Panel Session 1. Kicking Over the Traces

Noncatecholic Biogenic Amines and Their Receptors

American College of Neuropsychopharmacology

52nd Annual Meeting

Hollywood, Florida

22

2015 TAAR1 And Drugs of Abuse

Invited Plenary Symposium Speaker: 'TAAR1: from chemistry to behavior and its

implications in drug abuse'

Brain, Biology and Chemistry: Translational Research in Addiction

UT Health Science Center

,March 14-15, 2015

San Antonio, TX

2015 Trace Amine Associated Receptor 1 is Implicated in the Central and

Immunological Effects of Drugs of Abuse

Invited Symposium Speaker

American Society for Pharmacology and Experimental Therapeutics Annual

Meeting

Session Chair: EMERGING ROLES OF TRACE AMINE ASSOCIATED

RECEPTOR 1 (TAAR1) IN DRUG ABUSE AND MENTAL DISORDERS

Boston Convention & Exhibition Center

March 29, 2015

Boston, MA

International

2002 Genetic Diversity of Drug Targets in the Brain: Similarities Between Human and

Rhesus Monkey m-Opioid Receptor Variants


College on Problems of Drug Dependence

Quebec City

Quebec, Canada

2005 Rhesus monkeys as naturalistic models for deciphering genotype/phenotype

relationships relevant to human neuropsychiatric disorders

Invited Session Speaker

The 2nd International Conference on Primate Genomics & Human Disease

Seattle, Washington.

2008 Comparable functional polymorphisms in rhesus monkeys and human

neuropsychiatric genes


The 3nd International Conference on Primate Genomics & Human Disease

Seattle, Washington.

2010 Translational Genetic and Pharmacogenomic Modeling of Human

Neuropsychiatric and Drug Addiction Phenotypes

Program Committee Member and Invited Session Speaker

The 4th International Conference on Primate Genomics & Human Disease

Seattle, WA

23

2010 Session 3. Primate Genomics and AIDS

Session Chair


Seattle, WA

2010 The TAAR1 Receptor Orchestrates Trace Amine, Common Biogenic Amine and

Psychostimulant effects in Brain Monoaminergic Systems


The 14th Biennial International Amine Oxidase Workshop

Edmonton, Alberta, Canada

2011 Exploiting the Parallel Functional Polymorphisms and Pharmacogenomic

Responsivity Between Rhesus Monkeys and Humans for Drug Discovery:

A New Avenue for Preclinical Modeling to Advance Personalized Medicine for

Psychiatric and Addictive Disease.

Target Meeting 1st World Drug Discovery Online Conference

http://www.targetmeeting.com

2012 Session 2. Genomic and Primate Models of Health and Disease

Session Chair


Houston, TX

2012 A Systematic Phenotyping Strategy to Transform the Use of Rhesus Monkeys in

Biomedical Research



Houston, TX

2012 Trace Amine Associated Receptor 1 is a Catecholamine Receptor that

Differentially Controls DAT and NET Internalization


Theme B. Catecholamine Transporter Genetics

The Tenth International Catecholamine Symposium

Pacific Grove, California

2013 Trace Amine Associated Receptor 1 (TAAR1) Signaling Differentially Regulates

Dopamine and Norepinephrine Transporter Internalization

Invited Symposium Speaker

Session: Anatomy and physiology of dopamine systems

Topic: New Mechanisms by Which Trace Amine-Associated Receptors Modulate

Dopamine Neuron Activity

Dopamine 2013

Alghero, Italy

24

Education of Patients and Service to the Community

Activities

2010- 2013 Member, Executive Committee

2013- Member, Board of Directors

Community Connections Outreach on Substance Abuse

Sudbury, Massachusetts

2012 Organizer, “What were you thinking?”

Presentation of the teen brain

Lincoln Sudbury Regional High School

Sudbury, Massachusetts

2015 Invited Speaker

Nu Rho Psi National Honor Society in Neuroscience

Northeastern University Chapter

2015 Invited Speaker

Science Café

Franklin High School Biology Department

Franklin, Massachusetts

25

Scholarship

Peer reviewed publications in print or other media

1. Gibson MJ, Miller GM, Silverman A-J. Pulsatile luteinizing hormone secretion in normal

female mice and hypogonadal female mice with preoptic area implants. Endocrinology

1991;128:965-71.

2. Wu TJ, Segal AZ, Miller GM, Gibson MJ, Silverman A-J. FOS expression in gonadotropin-

releasing hormone neurons: enhancement by steroid treatment and mating. Endocrinology

1992;131:2045-50.

3. Silverman A-J, Roberts JL, Dong KW, Miller GM, Gibson MJ. Intrahypothalamic injection of

a cell line secreting gonadotropin-releasing hormone results in cellular differentiation and reversal

of hypogonadism in mutant mice. Proceedings of the National Academy of Sciences (USA)

1992;89:10668-72. PMCID: PMC50402

4. Miller GM, Silverman A-J, Roberts JL, Dong KW, Gibson MJ. Functional assessment of

intrahypothalamic implants of immortalized gonadotropin-releasing hormone secreting cells in

female hypogonadal mice. Cell Transplantation 1993;2(3):251-7.

5. Miller GM, Gibson MJ. Opioidergic modulation of N-methyl-D,L-aspartic acid (NMA)-

stimulated LH release in young adult but not older male mice. Neuroendocrinology 1994;59:277-

84.

6. Miller GM, Silverman A-J, Gibson MJ. Neuromodulation of transplanted GnRH neurons in

male and female hypogonadal mice with preoptic area brain grafts. Biology of Reproduction

1995;52:572-83.

7. Miller GM, Alexander JM, Bikkal HA, Katznelson L, Zervas NT, Klibanski A. Somatostatin

receptor subtype gene expression in pituitary adenomas. Journal of Clinical Endocrinology and

Metabolism 1995;80:1386-92.

8. Miller GM, Alexander JM, Klibanski A. Gonadotropin-releasing hormone mRNA expression

in gonadotroph tumors and normal human pituitary. Journal of Clinical Endocrinology and

Metabolism 1996;81:80-3.

9. Gibson MJ, Wu TJ, Miller GM, Silverman A-J. What nature's knockout teaches us about GnRH

Activity: Hypogonadal mice and neuronal grafts. Hormones and Behavior 1997;31(3):212-220.

10. Madras BK, Miller GM, Meltzer PC, Brownell A-L, Fischman AJ. Molecular and regional

targets of cocaine in primate brain: liberation from prosaic views. Addiction Biology 2000;5:351-

9.

11 Miller GM, De La Garza R, Novak MA, Madras BK. Single nucleotide polymorphisms

distinguish multiple dopamine transporter alleles in primates: Implications for association with

attention deficit hyperactivity disorder and other neuropsychiatric disorders. Molecular Psychiatry

2001;6:50-8.

26

12 Miller GM, Yatin SM, De La Garza R, Goulet M, Madras BK. Cloning of dopamine,

norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity.

Molecular Brain Reserach 2001;87(1):124-43.

13 Goulet M, Miller GM, Bendor J, Liu S, Meltzer PC, Madras BK. Non-amines, drugs without

an amine nitrogen, potently block serotonin transport: novel antidepressant candidates? Synapse

2001;42:129-40.

14 Miller GM, Madras BK. Polymorphisms in the 3’-untranslated region of human and monkey

dopamine transporter genes affect reporter gene expression. Molecular Psychiatry 2002;7(1):44-

55.

15 Madras BK, Miller GM, Fischman AJ. The dopamine transporter: Relevance to attention

deficit hyperactivity disorder (ADHD). Behavioral Brain Research 2002;130(1-2):57-63.

16 Yatin SM, Miller GM, Norton C, Madras BK. Dopamine transporter-dependent and –

independent c-fos induction by dopamine transporter substrates and inhibitors. Synapse

2002;45(1):52-65.

17 Madras BK, Fahey MA, Miller GM, De La Garza R, Spealman RD, Meltzer PC, George SR,

O’Dowd BF, Bonad AA, Livni E, Fischman AJ. Non-amine based dopamine transporter (reuptake)

inhibitors retain properties of amine-based progenitors. European Journal of Pharmacology

2003;479:41-51

18 Miller GM, Bendor J, Tiefenbacher S, Yang H, Novak M, Madras BK. A Mu-opioid receptor

single nucleotide polymorphism in rhesus monkey: Association with stress response and

aggression. Molecular Psychiatry 2004;9(1):99-108.

19 Madras BK, Miller GM, Yatin SM. Dopamine and norepinephrine transporter-dependent

immediate early gene production in vitro: new insights into psychostimulant-induced presynaptic

neuroadaptation. Journal of Neuroscience Methods 2005;143(1):69-78.

20 Madras BK, Miller GM, Fischman AJ. The Dopamine Transporter and Attention Deficit

Hyperactivity Disorder (ADHD). Biological Psychiatry 2005;57(11):1397-1409.

21 Jassen AK, Brown JM, Panas HN, Miller GM, Xiao D, Madras BK. Variants of the primate

vesicular monoamine transporter-2. Molecular Brain Research 2005;139(2):251-7.

22 Yatin SM, Miller GM, Madras BK. Dopamine and norepinephrine transporter-dependent c-

Fos production in vitro: relevance to neuroadaptation. Journal of Neuroscience Methods

2005;143(1):69-78. 23. Miller GM, Verrico CD, Jassen A, Konar M, Yang H, Panas H, Bahn M, Johnson R and

Madras BK. Primate trace amine receptor 1 modulation by the dopamine transporter. Journal of

Pharmacology and Experimental Therapeutics 2005;313(3):983-994.

27

24. Xiao D, Miller GM, Jassen AK, Westmoreland SV, Pauley D, Madras BK. Ephrin/Eph

Receptor Expression in Brain of Adult Nonhuman Primates: Implications for Neuroadaption.

Molecular Brain Research, 2006;1067(1):67-77.

25. Jassen AK, Yang H, Miller GM, Calder E, Madras BK. Receptor regulation of axon guidance

molecule gene expression. Molecular Pharmacology 2006;70(1):71-7.

26. Kumar, R, Orsoni1 S, Norman1 L, Tirado1 G, Verma1 AS, Staprans S, Miller G, Buch SJ,

Kumar A. Morphine Addiction Causes Pronounced Virus Replication in Cerebral Compartment

and Accelerated Onset of AIDS in SIV/SHIV-infected Indian Rhesus Macaques. Virology

2006;354(1):192-206.

27. Chen GL, Novak MA, Hakim S, Xie Z, Miller GM. Tryptophan hydroxylase-2 gene

polymorphisms in rhesus monkeys: association with hypothalamic-pituitary-adrenal axis function

and in vitro gene expression. Molecular Psychiatry 2006;11(10):914-28.

28. Madras BK, Xie Z, Lin Z, Jassen AJ, Panas H, Lynch L, Johnson RS, Livni E, Spencer TJ,

Bonab AA, Miller GM, Fischman AJ. Modafinil Occupies Dopamine and Norepinephrine

Transporters in vivo and Modulates the Transporters and Trace Amine Activity in vitro. Journal

of Pharmacology and Experimental Therapeutics 2006;319(2):561-9.

29. Newman RM, Hall L, Connole M, Chen G-l, Sato S, Yuste E, Diehl W, Hunter E, Kaur A,

Miller GM and Johnson WE. Balancing selection and the evolution of functional polymorphism

in old world monkey trim5alpha. Proceeding of the National Academy of Science (USA),

2006;103(50):19134-9. PMCID: PMC1679755

30. Verrico CD, Miller GM, Madras BK. MDMA (Ecstasy) and Human Dopamine,

Norepinephrine and Serotonin Transporters: Implications for MDMA-Induced Neurotoxicity and

Treatment. Psychopharmacology 2007;189(4):489-503.

31. Xie, Z, Westmoreland S, Bahn ME, Chen G-L, Yang H, Vallender E, Yao WD, Madras BK,

Miller GM. Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by

monoamine transporters and attenuation by the D2 autoreceptor in vitro. Journal of Pharmacology

and Experimental Therapeutics 2007;321(1):116-27.

32. Xie Z and Miller GM. Trace Amine-Associated Receptor 1 is a Modulator of the Dopamine

Transporter. Journal of Pharmacology and Experimental Therapeutics 2007;321(1):128-36.

33. Zhang JP, Vinuela A, Neely MH, Grant SG, Miller GM, Isacson O, Caron MG, Yao WD.

Inhibition of the Dopamine D1 Receptor Signaling by PSD-95. Journal of Biological Chemistry.

2007;282(21):15778-89. PMCID: PMC2649122

34. Chen GL and Miller GM. Rhesus Monkey Tryptophan Hydroxylase-2 Coding Region

Haplotypes Affect mRNA Stability. Neuroscience 2008;155(2):485-91. PMCID: PMC2644555

35. Chen G-L, Vallender EJ, Miller GM. Functional Characterization of the Human TPH2 5'

Regulatory Region: Untranslated Region and Polymorphisms Modulate Gene Expression In Vitro.

Human Genetics 2008;122(6):645-57. PMCID: PMC2734478

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16847459&query_hl=1&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Madras+BK%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Xie+Z%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Lin+Z%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Jassen+AJ%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Panas+H%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Lynch+L%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Johnson+RS%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Livni+E%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Spencer+TJ%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Bonab+AA%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Miller+GM%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Fischman+AJ%22%5BAuthor%5D

28

36. Lee AS, Gutierrez-Arcelus M, Perry GH, Vallender EJ, Johnson WE, Miller GM, Korbel JO

and Lee C. Analysis of copy number variation in the rhesus macaque genome identifies candidate

loci for evolutionary and human disease studies. Human Molecular Genetics 2008; 17(8):1127-36.

37. Xie Z and Miller GM. -Phenylethylamine Alters Monoamine Transporter Function via Trace

Amine-Associated Receptor 1: Implication for Modulatory Roles of Trace Amines in Brain.

Journal of Pharmacology and Experimental Therapeutics 2008;325(2):617-628.

38. Xie Z, Westmoreland SV, Miller GM. Modulation of Monoamine Transporters by Common

Biogenic Amines via Trace Amine-Associated Receptor 1 and Monoamine Autoreceptors in

HEK293 Cells and Brain Synaptosomes. Journal of Pharmacology and Experimental Therapeutics

2008;325(2):629-640.

39. Vallender EJ, Priddy CM, Chen G-L, Miller GM. Human Expression Variation in the mu

Opioid Receptor is Paralleled in the Rhesus Macaque. Behavior Genetics 2008;38(4):390-395.

40. Vallender EJ, Priddy CM, Hakim S, Yang H, Chen G-L, Miller GM. Functional variation in

the 3’ UTR of the serotonin transporter in human and rhesus macaque. Genes, Brain and Behavior

2008;7(6):690-7.

41. Xie Z, Vallender EJ, Yu N, Kirstein S, Yang H, Bahn M, Westmoreland SV, Miller GM.

Cloning, expression and functional analysis of rhesus monkey trace amine-associated receptor 6:

Evidence for lack of monoaminergic association. Journal of Neuroscience Research

2008;86(15):3435-46. PMCID: PMC2644554

42. Verrico CD, Lynch L, Fahey MA, Fryer A-K, Miller GM and Madras BK. MDMA-induced

impairment in primates: antagonism by a selective norepinephrine or serotonin, but not by a

dopamine/norepinephrine transport inhibitor. Journal of Psychopharmacology 2008;22(2):187-

202.

43. Vallender EJ, Lynch L, Novak MA, Miller GM. Polymorphisms in the 3' UTR of the serotonin

transporter are associated with cognitive flexibility in rhesus macaques. American Journal of

Medical Genetics Part B: Neuropsychiatric Genetics 2009;150B(4):467-75. PMCID:

PMC2702718

44. Chen GL and Miller GM. 5'-Untranslated Region of the Tryptophan hydroxylase-2 Gene

Harbors an Asymmetric Bidirectional Promoter but not Internal Ribosome Entry Site in vitro.

Gene 2009;435(1-2):53-62. PMCID: PMC2670360

45. Xie Z and Miller GM. A Receptor Mechanism for Methamphetamine Action in Dopamine

Transporter Regulation in Brain. Journal of Pharmacology and Experimental Therapeutics

2009;330(1):316-25. PMCID: PMC2700171

46. Ferguson B, Capitanio J, Folks T, Hotchkiss C, Johnson Z, Kean L, Kubisch HM, Lank S,

Lyons L, Miller GM, Nylander J, O'Connor D, Vallender EJ, Wiseman R. Resource brief: the

National Non-Human Primate DNA Bank. Methods. 2009;49(1):3-4. PMCID: PMC3172814

http://www.ncbi.nlm.nih.gov/pubmed/19706346?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

http://www.ncbi.nlm.nih.gov/pubmed/19706346?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

29

47. Kanthaswamy S, Capitanio JP, Dubay CJ, Ferguson B, Folks T, Ha JC, Hotchkiss CE,

Johnson ZP, Katze MG, Kean LS, Kubisch HM, Lank S, Lyons LA, Miller GM, Nylander J,

O’Connor DH, Palermo RE, Smith DG, Vallender EJ, Wiseman RW, Rogers J. Resources for

Genetic Management and Genomics Research on Non-Human Primates at the National Primate

Research Centers (NPRCs). Journal of Medical Primatology 2009;38 Suppl 1:17-23.

48. Xie Z and Miller GM. Trace amine-associated receptor 1 as a monoaminergic modulator in

brain. Biochemical Pharmacology 2009 78(9);1095-04. Review. PMCID: PMC2748138

49. Chen GL, Novak MA, Meyer JS, Kelly BJ, Vallender EJ, Miller GM. The Effect of Rearing

Experience and TPH2 Genotype on HPA Axis Function and Aggression in Rhesus Monkeys: a

Retrospective Analysis. Hormones and Behavior 2010;57(2):184-91. PMCID: PMC2815197

50. Vallender EJ, Ruedi-Bettschen D, Miller GM*, Platt DM. A pharmacogenetic model of

naltrexone-induced attenuation of alcohol consumption in rhesus monkeys. Drug and Alcohol

Dependence 2010;109(1-3):252-6. PMCID: PMC2875311 *Corresponding author

51. Vallender EJ, Xie Z, Westmoreland SV, Miller GM. Functional evolution of the trace amine

associated receptors in mammals and the loss of TAAR1 in dogs. BMC Evolutionary Biology

2010;10:51. PMCID: PMC2838891

52. Chen GL, Novak MA, Meyer JS, Kelly BJ, Vallender EJ, Miller GM. TPH2 5'- and 3'-

Regulatory Polymorphisms Are Differentially Associated with HPA Axis Function and Self-

Injurious Behavior in Rhesus Monkeys. Genes, Brain and Behavior 2010;9(3):335-347. PMCID:

PMC2990963

53. *Panas H, *Lynch L, Vallender E, Xie Z, Chen GL, Lynn S, Scanlan T and Miller GM.

Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like

psychostimulants in trace amine associated receptor 1 knockout mice. Journal of Neuroscience

Research 2010;88(9):1962-9. PMC Journal - In Process *Shared first-authorship; both are Research Assistant III’s in my lab.

54. Miller GM. The Emerging Role of Trace Amine Associated Receptor 1 in the Functional

Regulation of Monoamine Transporters and Dopaminergic Activity. Journal of Neurochemistry

2011;116(2):164-76. PMCID: PMC3005101 Review, contains new data not published elsewhere.

55. Karmacharya R, Lynn SK, Demarco S, Ortiz A, Wang X, Lundy MY, Xie Z,

Cohen BM, Miller GM, Buttner EA. Behavioral effects of clozapine: Involvement of trace

amine pathways in C. elegans and M. musculus. Brain Research 2011, Jun 1;1393:91-9. PMCID:

PMC3107707

56. Westmoreland SV, Annamalai L, Lentz MR, Ratai EM, Assaf B, Boisvert K, Huynh T,

Vallender EJ, Miller GM, Madras BK, Gonzalez RG. Growth associated protein-43 and Ephrin

B3 Induction in the Brain of Adult SIV-infected Rhesus Macaques. Journal of Neurovirology.

2011. In press. PMC Journal - In Process

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Chen%20GL%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Novak%20MA%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Meyer%20JS%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Kelly%20BJ%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Vallender%20EJ%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Miller%20GM%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Chen%20GL%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Novak%20MA%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Meyer%20JS%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Kelly%20BJ%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Vallender%20EJ%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Miller%20GM%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract

30

57. Lewin AH, Miller GM, Gilmour B. Trace amine-associated receptor 1 is a stereoselective

binding site for compounds in the amphetamine class. Bioorganic & Medicinal Chemistry Dec

1;19(23):7044-8, 2011. PMCID: PMC3236098

58. Achat-Mendes C, Lynch LJ, Sullivan KA, Vallender EJ, Miller GM. Augmentation of

methamphetamine-induced behaviors in transgenic mice lacking the trace amine-associated

receptor 1. Pharmacol Biochem Behav. Apr;101(2):201-207, 2012. PMCID: PMC3288391

59. Chen G-L and Miller GM. Advances in Tryptophan Hydroxylase-2 Gene Expression

Regulation: New Insights into Serotonin-Stress Interaction and Clinical Implications. American

Journal of Medical Genetics Part B: Neuropsychiatric Genetics. Mar;159B(2):152-171, 2012

PMC Journal - In Process

60. Miller GM. Avenues for the Development of Therapeutics That Target Trace Amine

Associated Receptor 1 (TAAR1). Journal of Medicinal Chemistry, Mar 8;55(5):1809-1814,

2012. PMCID: PMC3618978

61. Panas MW, Xie Z, Panas HN, Hoener MC, Vallender EJ, Miller GM. Trace Amine

Associated Receptor 1 Signaling in Activated Lymphocytes. Journal of Neuroimmune

Pharmacology Dec;7(4):866-76, 2012 PMC Journal - In Process

62. Chen GL, Miller GM. Tryptophan Hydroxylase-2: An Emerging Therapeutic Target for

Stress Disorders. Biochem Pharmacol. 2013 Feb 19 [Epub ahead of print], In press.

63. Chen GL, Miller GM. Extensive Alternative Splicing of the Repressor Element Silencing

Transcription Factor Linked to Cancer. PLOSOne 2013 Apr 16;8(4):e62217. PMCID:

PMC3628349

64. Lynch J*, Sullivan KA*, Vallender EJ, Rowlett JK, Platt DM, Miller GM. Trace Amine

Associated Receptor 1 Modulates Behavioral Effects of Ethanol. Substance Abuse: Research and

Treatment. 2013, Jun 4;7:117-126. PMC Journal - In Process * both are Research Assistant III’s in my lab.

65. Vallender EJ and Miller GM. Non-Human Primate Models in the Genomic Era: A Paradigm

Shift. Institute for Laboratory Animal Research Journal 2013 54: 154-165.

66. Dharmendra B Goswami DB, Ogawa LM, Ward JM, Miller GM, Vallender EJ. Large-scale

polymorphism discovery in macaque G-protein coupled receptors. BMC Genomics 2013,

14:703. PMC Journal - In Process

67. Cho JA, Zhang X, Miller GM, Lencer WI, Nery FC. 4-phenylbutyrate attenuates the ER Stress

Response and Decreases Cyclic AMP Accumulation in DYT1 Dystonia Cell Models. PLOSOne

2014, Nov 7;9(11):e110086

68. Yasuda K, Oh K, Ren B, Tickle TL, Franzosa EA., Wachtman LM., Miller AD,

Westmoreland SV, Mansfield KG, Vallender EJ, Miller GM, Rowlett JK., Gevers D,

Huttenhower C. Morgan XC. Biogeography of the intestinal mucosal and lumenal microbiome in

the rhesus macaque. In press. Cell Host and Microbe 2015, 17(3):385-91.

http://www.sciencedirect.com/science/journal/09680896






31

Non-peer reviewed scientific or medical publications/materials in print or other media

1. Madras B, Miller GM, De La Garza R, Dougherty DD, Bonab AA, Spencer TJ, Rauch SL,

Fischman AJ. Brain Imaging of the dopamine transporter in ADHD. 6th International World

Congress for Biomedical.Sciences 2000;113. PMC Journal - In Process

2. Gibson MJ, Saitoh Y, Miller GM, Silverman A-J. Functional GnRH neuronal transplants in the

hypogonadal mouse. In: Crowley WF Jr, Conn PM, editors. Modes of Action of GnRH and GnRH

analogs. New York, New York: Springer-Verlag, 1992:144-57.

3. Miller GM, Zhang X, Klibanski A. Pituitary tumors: future perspectives. In: Kovacs, K. editors.

Diagnosis and management of pituitary tumors. Totowa, New Jersey: Humana Press Inc., 2001,

pgs 462-6.

4. Miller GM and Madras BK. Genetic Variations and Phenotypic Associations Common to

Rhesus Monkeys and Humans. In: SA Wolfe-Coote, editor. The Laboratory Primate. Tygerberg,

South Africa: Medical Research Council of South Africa, Elsevier Publishing Inc., 2005.

5. Ferguson B, Miller GM. Genetic tools for understanding the primate genome. Methods

2009;49(1):1-2. Editorial.

Thesis

1. Miller GM. Neuromodulation of luteinizing hormone secretion in the mouse [dissertation]. New

York (NY): City Univ. New York, 1993.

date prepared august 28, 2015...date prepared august 28, 2015 name gregory m. miller ph.d. office...

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