Date: 2012-04-04 Last day for submission of tender: 2012-05-24

Validity of tender: 2012-09-30

Ref no: LiU-2012-00501 Procurement procedure: Open procedure

INVITATION TO TENDER

Core facility, Faculty of Health Sciences at Linköpings universitet, Sweden wishes to procure an ultra-high resolution mass

spectrometry system.

You are hereby invited to submit a tender according to the conditions stated in these contract documents.

Linköpings universitetCore facility

SE-581 83 Linköping

1. ADMINISTRATIVE REGULATIONS

1.1. GENERAL INFORMATION

Linköpings universitet (LiU) intends to buy new equipment with a possible trade in of a QSTAR-Pulsar mass spectrometer (from the year 2000) to support research projects based on LC-tandem mass spectrometry within the Core Facility, Faculty of Health Sciences, LiU. LiU intends to move up to the latest generation ultra-high resolution mass spectrometry system with highest analytical power. Emphasis will be put on flexible solutions for a wide range of proteomics applications in Life Sciences and Medicine and on novel technologies allowing top-down proteomics.

1.1.1. Scope

The mass spectrometry laboratory of the Core Facility infrastructure serves advanced research projects at the Faculty of Health Sciences, the Institute of Technology of Linköping University and Linköping University Hospital. This facility has been established for the use of expensive equipment required in a wide range of applications in Life Sciences and Medicine. The equipment will be acquired using investments from the County Council of Östergötland and The Knut and Alice Wallenberg Foundation, which 12 years ago financed acquisition of the largest mass spectrometer in the facility. In order to maintain the ability of the infrastructure in achieving the scientific aims and its long-term significance for the research areas we now want to obtain an instrument of the new generation - an ultra-high resolution mass spectrometry system with novel technologies allowing top-down proteomics, biomarker discoveries and metabolic studies. The ultra-high resolution mass spectrometry system will be used for analyses of: multiple post-translational modifications of proteins; histone code and insulin signaling in type 2 diabetes; protein folding, misfolding and synthetic organic chemistry; sensing communication between bacteria, epithelial cells and immune cells; regulation of survival and differentiation of hematopoietic stem cells and leukemia-initiating cells; biomarker discovery; environmental proteomics and metabolomics.

1.2. CONTRACTING ENTITY

Linköpings universitetCore FacilitySE-581 83 LinköpingSweden

1.2.1. Contact person

Questions concerning this procurement should be addressed to:

Erland Ljunggren, upphandling@liu.se .

If the tenderer wishes clarification of any aspects of the Contract documents, questions must be submitted in writing directly to the contact person for this procurement, no later than the 18th of May 2012. Questions after this date will not be answered. Enquiries will be answered and published at http://www.liu.se/upphandlingar/ . The tenderer is solely responsible for obtaining complete documentation.

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1.2.2. Additions/amendments

Complementary additions/amendments if any to the contract documents will be announced at http://www.liu.se/upphandlingar.

1.3. CONTRACT DOCUMENTS

1.3.1. List of documents

The contract documents consist of the following documents and appendices: This document - administrative regulations, qualifications of the tenderer, technical

specifications, public contract (draft), appendix 1, ALOS 05 E, appendix 2, declaration of truthfulness, appendix 3.

The tenderer is solely responsible for obtaining complete documentation.

1.3.2. Disposition of the contract documentsThe administrative regulations contain requirements about formality and administration and also describe how the qualification of the tenderer as well as the evaluation of the tender is performed. The technical specifications contain specific requirements concerning the product. The commercial conditions stipulate requirements for the public contract.

1.4. PROCUREMENT PROCEDUREThis is a open procurement procedure, in accordance with the Swedish law of public procurements (SFS 2007:1091).

1.5. THE TENDER – FORMAL REQUIREMENTS

1.5.1. Validity of the tenderThe tender is valid provided that it is: signed by an authorized representative of the tendering company, submitted no later than 24th of May 2012 . The tenderer is solely responsible for the timely arrival of the tender. A tender that arrives later than stipulated, will not be considered, valid until 30th of September 2012, which explicitly must be confirmed in the tender.

1.5.2. Formality of the tenderFormal requirements for the tenders are as follows: written in the Swedish or English language, submitted in a closed envelope/package marked with “ANBUD/TENDER” and

reference LiU-2012-00501. Please note that tenders submitted by delivery firms will need the envelope / outer packaging to bear the tender number also,

submitted as hard copies (one (1) original and two (2) complete copies) as well as (1) complete electronic version (on USB memory stick or CD/DVD media) in MS Word *.docx format or equivalent format.

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Tenders submitted by fax or e-mail will not be accepted, since confidentiality cannot be guaranteed.

1.5.3. Submission of tenderThe tender can either be sent by regular or courier mail or be delivered personally at the address below:

Visiting and express delivery address: Mailing address:Linköpings universitet Linköpings universitetRegistrator, Building Origo RegistratorSE-58183 Linköping, Sweden SE-58183 Linköping, Sweden

Office hours are Monday – Friday 09.00 – 15.00. There is a small mailbox (width: 27, 5 cm, height: 3, 5 cm) outside the Origo building were tenders can be delivered. Keep in mind that tenders are submitted at the risk of the tenderer, and to ensure that the tender is timely submitted, office hours must be strictly adhered to.

The contact person will send a notice of delivery upon opening of the received tenders.

1.5.4. Disposition of the tenderTo ensure equal treatment and to facilitate assessment of tenders, the tenderer is requested to follow the order and numbering of this document.

If no statement is made concerning a specific requirement, the contracting entity is entitled to interpret this as the requirement is not fulfilled.

1.6. EVALUATION PROCESSBefore the evaluation process starts, the formal requirements are checked in accordance with 1.5. If any of those are not fulfilled, the tender in question may not be taken into consideration.

1.6.1. Qualification of the tendererThe requirements in chapter 2 are to ascertain that the tenderer has the necessary technical ability and capacity to fulfill the obligations concerning this public procurement. To qualify, these requirements have to be fulfilled.

1.6.2. ExaminationThereafter the requirements indicated as “must” in sections 3 and 4, will be checked. Only tenders that fulfill all these requirements will be evaluated further.

1.6.3. Evaluation

The examination of tenders will be made choosing the economically most advantageous tender based on the criteria given below in order of importance:

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Criteria Weight

1. Function and performance of the whole LC/MS/MS system. 50-60 %

2. Versatility of system control, data acquisition and data processing. 20-25 %

3. Price and swiftness of technical support, service and delivery time. 10-12,5 %

4. Equipment price. 10-12,5 %

Final weight for each criterion will be determined within the stated span at the time of evaluation. The percentage intervals chosen for this procurement will be described in the evaluation and the accompanying PM that is sent out together with our decision.

The tenders will be evaluated regarding fulfillment of the “should” and “specify”- requirements, and given points in accordance within the intervals stated at each requirement in the “Technical specifications” chapter 3, the “Price and swiftness of technical support, service and delivery time” chapter 4 and the “Equipment price and payment terms” chapter 5. The number of evaluation points awarded for each item will be based on the quality of the equipment and the standard of the customer service.

Criterion 1: Function and performance of the whole LC/MS/MS system

Once the basic points are set all tenders will receive a mark between 0 and 50 for the criterion, based on the formula below for criterion 1. Criterion 1 sections: 3.2.1.-3.2.7.

50sumpoint maximum The

points of sum achieved s tender'The

Criterion 2: Versatility of system control, data acquisition and data processing

Once the basic points are set all tenders will receive a mark between 0 and 50 for the criterion, based on the formula below for criterion 2. Criterion 2 sections: 3.3.1-3.3.6.

50sumpoint maximum The

points of sum achieved s tender'The

Criterion 3: Price and swiftness of technical support, service and delivery time

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Once the basic points are set all tenders will receive a mark between 0 and 50 for the criterion, based on the formula below for criterion 3. Criterion 3 sections: 4.1-4.8

50sumpoint maximum The

points of sum achieved s tender'The

Criterion 4: Equipment price, trade in and payment terms

Tenders will be ranked with regard to the lowest total price offered. NOTE! 4.7.“Service II” costs are not included in the total price. Criterion 4 sections: 5.1-5.5

50price totals tender'The

price offeredLowest

1.6.4. Final resultThe sum of the weighted marks will be the final total mark:

(points criterion 1 x weight) + (points criterion 2 x weight) + (points criterion 3 x weight) + (points criterion 4 x weight) = final total mark

This final total mark corresponds to the economically most advantageous tender.

1.7. COMMERCIAL SECRECY

In accordance with the Public Access to Information and Secrecy Act (SFS 2009:400 Offentlighets- och sekretesslag) all data pertaining to a procurement matter is subject to secrecy until an agreement has been entered into or procurement has otherwise been concluded.

Any data mentioned may be subject to secrecy even after the aforementioned time. Note, however that only in exceptional cases are data and prices pertinent to the evaluation of the tender considered to be of such nature that they may be held secret for commercial reasons. With respect to commercial secrecy for the protection of a tenderer’s data, the requirement is that the data in question refers to the tenderer’s business- or service conditions and that there is a specific reason to presume that the tenderer will suffer damage if the data is disclosed.

If a tenderer considers that the data submitted in connection with this procurement matter fulfills the aforementioned requirements for commercial secrecy, the tenderer must submit a request for commercial secrecy, in writing; specifying the data in question as well as the damage the tenderer would suffer if the data were disclosed.

The decision whether or not the data submitted by the tenderer fulfills the requirements for commercial secrecy will be made by the Contracting Entity.

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1.8. NOTIFICATION OF DECISION

Prior to signing the public contract, notification of the contracting entity´s decision in this procurement matter will be sent in writing to all tendering parties.

An appeal for reconsideration of this decision may be made to the Administrative Court in Linköping. Such an appeal has to be sent within 10 days from receipt of the decision.

Address: Förvaltningsrätten , Box 406, SE-581 04 Linköping, SwedenE-mail: forvaltningsrattenilinkoping@dom.se

1.9. AGREEMENT

Please note that there is no legally binding agreement until a public contract is signed by both parties.

2. QUALIFICATION OF TENDERER To ensure that the tenderer is suitable as a supplier for the specified procurement, the requirements below must be fulfilled.

2.1. LEGAL POSITION

According to the Swedish law of public procurement (LOU) the tenderer may not:

be in bankruptcy or liquidation proceedings, or be under compulsory administration or subject to composition or have ceased making payments until further notice or be subject to trade prohibition. be subject to filing for bankruptcy, compulsory liquidation, compulsory administration, composition or other similar proceedings. have been found guilty of unprofessional conduct according to final and conclusive judgment. have been found guilty of serious wrongdoings in professional conduct. have failed to fulfill liabilities concerning taxes and social fees.

Furthermore, checks are made that:

the tenderer is registered in companies’ register, commercial register or similar register. the tenderer is registered for reporting and payment of taxes, withheld preliminary tax and employer fees.

The tenderer must confirm that there are no grounds for exclusion according to the above, through provision of the documents mentioned below:

Tenderer located abroad The following national official documents must be enclosed with the tender:1) certificate of enrolment in a professional trade register,2) certificate that the tenderer has fulfilled obligations relating to the payment of social security contributions,

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3) certificate that the tenderer has fulfilled obligations relating to the payment of taxes

Swedish tenderer Registreringsbevis from Bolagsverket must be enclosed. The purchaser will check with Skatteverket regarding payment of taxes and social security contributions.

All tenderer Appendix 3, “Tender form/Declaration of truthfulness” must also be signed and enclosed with the tender.

The information must not be older than 3 months from last day for submission of tender.

2.2. SUBCONTRACTORS

If the tenderer intends to engage subcontractors to perform certain parts or services, these shall be stated, and specified in the tender. Documents, as presented in section 2.1, must be appended for each subcontractor.

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3. TECHNICAL SPECIFICATIONS

3.1. GENERAL DESCRIPTION OF THE EQUIPMENT

LiU intends to buy a new equipment with a trade in of the QSTAR-Pulsar mass spectrometer (from the year 2000) to support research projects based on LC-tandem mass spectrometry within the Core Facility, Faculty of Health Sciences, Linköping University. LiU intends to move up to the latest generation ultra-high resolution mass spectrometry system with highest analytical power. Emphasis will be put on flexible solutions for a wide range of proteomics applications in Life Sciences and Medicine and on novel technologies allowing top-down proteomics.

NOTE!: The points given for each “should”, and “specify” request show the maximum points attainable for that item upon evaluation of the tender. The maximum number of points will only be given to requests that are better than the criteria asked for , accompanied with an adequate description or specification that will allow the evaluators to judge the technical solution (if applicable).

3.2. FUNCTION AND PERFORMANCE OF THE WHOLE LC/MS/MS SYSTEM.Below follows system specific requests corresponding to evaluation criteria 1 in section1.6.3.

3.2.1. Functional assessmentFulfilledYes No

Each company participating in the tender will receive two samples: one containing peptide mixture for the bottom-up proteomics analyses and the other with a protein of about 10 kDa for top-down protein sequencing. Evaluation of the instruments according to the criteria 1 and 2 in section 1.6.3. will be done on the basis of the proteomics data obtained after analyses of these samples.

NOTE! The analysis data must be reported in the tender (extended 10 days from the mandatory 40 day period for open procurements), in order to get your samples use the contact stated in section 1.2.1.Specify analysis data (0 – 30p):     

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3.2.2. A fully functional system

FulfilledYes No

All components and peripherals in terms of hardware and software, with associated licenses, necessary to achieve the level of integration and technical specifications stated in the tender, must be included in the offer. The equipment must be optimized for automated LC/MS/MS with high-quality performance.

3.2.3. Ion spray

FulfilledYes No

The equipment must be an ultra-high resolution mass spectrometer equipped with ion spray that must allow stable flow rates of 0.1-10 µl/min (microliters/min).

3.2.4. Mass accuracy, resolution and acquisition RATE

FulfilledYes No

The instrument must deliver mass accuracy below 1 ppm, at least 50000 resolution at up to 20Hz acquisition rate and high sensitivity analysis.

3.2.5. Electron transfer dissociation (ETD) technique

The instrument must perform peptide and protein sequence analyses using the electron transfer dissociation (ETD) technique that preserves and identifies multiple post-translational protein modifications. Sensitivity, resolution and mass accuracy should be specified for the instrument in different experimental modes.Specify sensitivity, resolution and mass accuracy in different experimental modes (0 – 20p):     

3.2.6. Mapping of complex peptide modificationsFulfilledYes No

The instrument must perform high quality MS/MS analyses allowing mapping of complex peptide modifications.

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3.2.7. Integration into a dedicated LC-MS/MS systemFulfilledYes No

The instrument must be integrated into a dedicated LC-MS/MS system at the Core Facility The integration can be made in two different ways the first option is preferred:

1) the tenderer provides nano-LC system together with the mass spectrometer.

or

2) the mass spectrometer should be coupled to the HPLC system (Agilent 1100/1200) complemented with a static splitter to reduce a solvent flow rate to 5-9 µl/min (microliters/min), which has already been acquired by the Core Facility.

A maximum of 20 points will only be awarded to tenders that offer option 1.Specify integration option (0 – 20p):     

3.3. VERSATILITY OF SYSTEM CONTROL, DATA ACQUISITION AND DATA PROCESSING.Below follows system specific requests corresponding to evaluation criteria 2 in section1.6.3.

3.3.1. System software control IFulfilledYes No

The entire LC/MS/MS system (including autosampler, LC, diode-array and mass spectrometer) must be controlled and operated by single computer software.

3.3.2. System software control IIFulfilledYes No

A provided computer for system control and data acquisition must provide complete automated control of autosampler, LC, ion path optics, interface electronics, polarity switching, as well as gas supplies to mass spectrometer and ion sources.

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3.3.3. Software upgradesFulfilledYes No

New or upgraded versions of the softwares must be free of charge during the warranty period. The policy regarding the costs and installation of new or upgraded versions of the softwares after the warranty time must be included in the description of the service commitments.

3.3.4. Data processing software I

Data processing software should have capacity for searches based on mass and fragmentation spectra, should have fragmentation interpretation tools and make automated quantitative data processing and reporting. The software should have a complete set of automated processing tools including de novo sequencing and sequence tag generation, protein, peptide reconstruction and peptide mapping algorithm. It should make fast database searches for protein ID. It should allow identification of novel modifications and amino acid substitutions. The software should perform MS BLAST searching for protein identification from highly modified proteins.

NOTE! If possible include a demo version/full version/instructional video of the software so the user-friendliness and tools can be assessed/verified.Specify the data processing software ( 0 – 20p):      

3.3.5. Data processing software II

Licenses for the data analysis software should be provided for several different PCs belonging to the users of Core Facility.Specify number of licenses for the analysis software included ( 0 – 5p):      

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3.3.6. Data processing software IIIFulfilledYes No

Upgrading to newer versions of software must be provided free of charge at least during the warranty period for the instrument. Specify if any version upgrades of the software is included free of charge after the warranty period.Specify possible extension of version upgrades in years ( 0 – 5p):      

4. Price and swiftness of technical support, service and delivery time.Below follows system specific requests corresponding to evaluation criteria 3 in section1.6.3.

4.1. DELIVERY SCHEDULE AND INSTALLATION

FulfilledYes No

Time for complete delivery must be stated in weeks. If delivery time is stated in intervals, the longest delivery time will be evaluated. Complete delivery includes installation, set up of operation, completed acceptance tests, and scheduling of training at Linköping University.Specify time for delivery (0-5):     

4.2. SITE REQUIREMENTS

FulfilledYes No

The tender must specify any special requirements of the installation site (in addition to 230 or 400 V AC outlets) to make it suitable for delivery and installation.Specify:     

4.3. INSTALLATION TEST AND FINAL ACCEPTANCE TEST

FulfilledYes No

Upon installation representatives of the Contractor and Core facility, LiU must together test that system performance is in accordance with specifications given in the tender (Installation test).

If the installation test is approved there will be a test period of one (1)

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month with follow-up tests by Core facility (Acceptance test). The Acceptance test period will start immediately after the training specified in the tender has been completed see section 4.5.

If the Acceptance test shows that the delivered equipment is working according to specifications given in the tender, the equipment will be approved and accepted by LiU.

If the tests show that the delivered equipment does not fulfill the tender performance specifications including software faults, the Contractor can perform necessary adjustments/repair followed by another Acceptance test period of one (1) month.

4.4. TRANSFER OF KNOWLEDGE AND TRAINING ON THE EQUIPMENT

On-site training of personnel in the Core Facility must be provided after the system installation and must be included in the price (section 5.1.).Specify how you plan to provide us with this.Specify (0 – 10p):     

4.5. WARRANTY AND FULL SERVICE

1FulfilledYes No

Proposals must state what level of warranty is offered for manufacture and workmanship of the system and the duration of this. At least one year warranty and full service for the purchased equipment must be included in the price (section 5.1.) from the day when the whole LC/MS/MS system is accepted by the Core Facility.Specify numbers of years of warranty (0 – 10p):     

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4.6. SERVICE I

FulfilledYes No

Service levels for the purchased system, as well as organization responsible for the service and its experience must be well documented. Information about the methods and time limits for repair must be provided.Specify offered service (0 – 10p):      

4.7. SERVICE II

FulfilledYes No

Contact information including telephone, fax, e-mail and name of contact person responsible for the provided service must be stated in the tender. Costs for spare parts and service contracts after the end of the first year warranty (extra years of warranty added as a response in 4.5. does not need to be specified) and full service contract must be specified for a period of total 4 years after the first year that must be included in the price.

NOTE! The service contract costs for the additional 4 years are not to be covered by the 4 100 000 SEK price limit.Specify contact information and costs for service options (0-10p):      

4.8. DOCUMENTATION

FulfilledYes No

A detailed documentation in English of all delivered equipment, its operation, maintenance and service as well as trouble-shooting schemes must be included and supplied upon delivery (documentation available in both paper and electronic formats is accepted).

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5. Equipment price and payment terms.Below follows system specific requests corresponding to evaluation criteria 4 in section1.6.3.

5.1. PRICE

FulfilledYes No

Price must be clearly specified, given in SEK, excluding Swedish VAT. The total contract price must be given as DAP (INCOTERMS 2010), which includes transportation and insurance costs to the site of installation on-site Core facility. The price includes installation, set up of the system, system testing and training of personnel. One year of warranty and full service must be included. A detailed description of what is included in the price must be given. All payments must be against invoice 30 days net.

The price limit is 4 100 000 SEK, excluding Swedish VAT.Specify the price:     

5.2. TRADE IN

FulfilledYes No

Tenders should accept a trade in of the QSTAR-Pulsar mass spectrometer (from the year 2000). This equipment is to be removed from Core facility when the new system arrives. The tender should specify the price reduction that this trade in generates. The price limit is 4 100 000 SEK, excluding Swedish VAT, minus the price reduction of the trade in.Specify the price reduction of the trade-in:     

5.3. PAYMENT TERMS I

FulfilledYes No

The tender must include the total contract price, given as DAP (INCOTERMS 2010) on-site Core Facility incl. freight, transport and insurance costs, installation, setting the system into operation, testing, documentation, training (including travelling costs) and warranty.

5.4. PAYMENT TERMS II

FulfilledYes No

Propose a payment schedule for the contract which will be subject to final agreement with the purchaser. The schedule must include at least 20 % to be paid following approved final acceptance test.Specify proposed payment schedule:     

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5.5. DRAFT CONTRACT

FulfilledYes No

The included commercial conditions (Appendix 1, Public Contract) are presumed to form the basis for an agreement between the parties.Comments:     

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