day 1 am (june 29 (mon)) program › document › program_en.pdf · s4-5 interaction and cross-talk...

Day 1 AM (June 29 (Mon))

Track 1

Invited Lecture June 29 (Mon) 9:30 - 10:30Track 1

Chair: Akihiko HIROSE (National Institute of Health Sciences)

IL International advances in tiered assessment for combined exposures: Incorporating novel assessment methods ○ Mary E. MEEK

McLaughlin Centre, University of Ottawa, Canada

Special Lecture 1 June 29 (Mon) 10:40 - 11:10Track 1


SL1 The objective of Stockholm Convention and the procedure of designating POPs○ Masaru KITANO

Akikusagakuen Junior College

Special Lecture 2 June 29 (Mon) 11:20 - 12:20Track 1


SL2 PFAS: Emerging, But Not New○ Christopher P. WEIS

National Institute of Environmental Health Sciences/NIEHS, USA

Track 2

Symposium 1 June 29 (Mon) 9:30 - 11:30Track 2

New insight for Developmental and Reproductive ToxicologyChairs: Tadahiro SHINOZAWA ( Global Drug Safety Research and Evaluation, Research, Takeda Pharmaceutical

Company Limited)

Masao HORIMOTO (Faculty of Risk and Crisis Management, Chiba Institute of Science)

Introduction S1-1※ Future perspective of evaluation for developmental and reproductive

toxicity of human pharmaceuticals○ Masao HORIMOTO

Faculty of Risk and Crisis Management, Chiba Institute of Science

The abstract which has 「※」 after program number can NOT be watched on the web after the conference.

Pro

gram

(J

une

29

, AM

)

S1-2 A trial of in vitro spermatogenesis using castrated bovine testis○ Kenshiro HARA

Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University

S1-3 Early prenatal diagnosis and fetal medicine ○ Tomoyuki ICHIDA, Kenji HISHIKAWA, Kazuya OONUMA, Takanori FUKUDA, Takeshi KUSAKA, Yutaka KOHATA, Hiromi INOUE

Shonan Kamakura General Hospital

S1-4※ A novel in vitro approach for embryo-fetal risk assessment using human iPS cells○ Maya KIMURA, Akimitsu MIYAWAKI, Yuko IZUMI, Kiyoshi MATSUMOTO, Tadahiro SHINOZAWA

Takeda Pharmaceutical Company Limited

Track 3


Evolution of new computational toxicology for pharmaceutical: System construction under ontologyChairs: Hajime KOJIMA (National Institute of Health Sciences)

Hiroshi YAMADA ( Toxicogenomics Informatics Project, National Institutes of Biomedical Innovation, Health and Nutrition)

Introduction S2-1 Systematization of computational toxicology for decision making in

drug discovery and development○ Ikuo HORII

Pfizer

S2-2 Tentative○ Yasushi OKUNO

Department of Biomedical Data Intelligence, Graduate School of Medicine, Kyoto University

S2-3※ Safety assessment based on the mechanism of toxicity from the viewpoint of pharmacokinetics: Current and future prospects of computer systems○ Masato KITAJIMA

Next Generation Social Solutions Unit, Fujitsu Kyushu Systems Limited

S2-4 Deployment of ontological intellection to computational toxicology○ Yuki YAMAGATA

Toxicogenomics Informatics Project, National Institutes of Biomedical Innovation, Health and Nutrition

Discussion Conclusion

Program

(J

une 29

, AM

)

Track 4


Current understanding of clinical and non-clinical toxicology of cancer immunotherapyChairs: Kazushige MAKI (Pharmaceuticals and Medical Devices Agency)

Takanori IKEDA (MSD K.K.)

S3-1 Nonclinical studies on CRS risk with cancer immunotherapy○ Masayuki MISHIMA

Chugai Pharmaceutical

S3-2 Preclinical safety evaluation of cancer immunotherapy products at PMDA○ Mizuho NONAKA

Pharmaceuticals and Medical Devices Agency

S3-3 Current understanding of clinical and non-clinical toxicology of cancer immunotherapy○ Rodney PRELL

Genentech, USA

Track 5


Cutting edge researches of sulfur metabolisms in molecular toxicologyChairs: Takaaki AKAIKE (Tohoku University Graduate School of Medicine)

Tomohiro SAWA (Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University)

Introduction S4-1 Defense mechanism and energy metabolism depending on reactive

sulfur species○ Hozumi MOTOHASHI

Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University

S4-2 Regulation of electrophilic stress by reactive sulfur species○ Hideshi IHARA

Department of Biological Science, Graduate School of Science, Osaka Prefecture University

S4-3 Innateinflammationregulationbyreactivesulfurspecies○ Tomohiro SAWA

Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University

S4-4 Discoveryofpolysulfidepoolsinhumanbiologicalfluidsandtheirphysiological functions○ Yu ISHIMA, Mayumi IKEDA, Tatsuhiro ISHIDA

Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University

Pro

gram

(J

une

29

, AM

)

S4-5 Interaction and cross-talk of selenium and sulfur metabolism: discrimination and control in vivo○ Yoshiro SAITO

Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University

Track 6


JPS - JSOT Joint Symposium: Current status and future perspectives on neurotoxicity testing for chemical compoundsChairs: Kouichi YOSHINARI (University of Shizuoka)

Yaichiro KOTAKE (Graduate School of Biomedical and Health Sciences, Hiroshima University )

S5-1 Evaluation of in vivo neurotoxicity by analysis on aberrations in hippocampal neurogenesis○ Makoto SHIBUTANI

Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology

S5-2 Developmental neurotoxicity evaluation using hippocampal slices obtained from rat pups at lactation period○ Susumu UENO

Department of Occupational Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan

S5-3※ Development of new safety testing method using human iPSC technology○ Yasunari KANDA

Division of Pharmacology, National Institute of Health Sciences

S5-4※ In vitro toxicity assessment based on a function of hiPSC-derived neurons and AI○ Ikuro SUZUKI

Department of Electronics, Tohoku Institute of Technology

Track7

Candidates for the Excellent Presentation Award (Oral) 1 June 29 (Mon) 9:30 - 10:24Track 7

Chairs: Hitomi FUJISHIRO ( Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University)

Saori MATSUO (Chugai Pharmaceutical Co., Ltd.)

Pharmaceutical drugs (chemicals)P-1E Novelmechanismsbywhichthemoleculartargetdruggefitinib

suppresses cancer cell invasion ○ Yuto SEKIGUCHI, Yusuke HIRATA, Takuya NOGUCHI, Atsushi MATSUZAWA

Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.

Program

(J

une 29

, AM

)

Regenerative medicine and cell therapyP-2E Development of safety assessment system using primate model for

practicaluseofgeneticallymodifiedTcells○ Hidemi MOCHIZUKI1, 2, Kengo SAKAMOTO1, Hirokazu MOROKAWA2, 3, Miyuki TANAKA2, 3, Shoji SAITO2, 3, Shigeki YAGYU2, 4, Yozo NAKAZAWA2, 3, Akihito SHIMOI1, 2

1Ina Research Inc., 2Center for Advanced Research of Gene & Cell Therapy, Shinshu University, 3Department of Pediatrics, Shinshu University School of Medicine, 4Department of Pediatrics, Kyoto Prefectural University of Medicine

MetalsP-8E Mechanism involved in the induction of OSM expression by

methylmercury in microglia○ Takayuki HOSHI1, 2, Takashi TOYAMA1, Akira NAGANUMA1, Yoshiro SAITO1, Gi-Wook HWANG1, 2

1Graduate School of Pharmaceutical Sciences, Tohoku University, 2Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University

P-16E※ Enhanced cytotoxicity and altered biglycan synthesis in vascular endothelial cells by cadmium through induction of CHSY1 expression○ Takato HARA1, Shogo MATSUURA1, Keita AIKAWA1, Shuta ONIZAWA1, Mai YOSHIDA1, Toshiyuki KAJI2, Chika YAMAMOTO1

1Faculty of Pharmaceutical Sciences, Toho University, 2Faculty of Pharmaceutical Sciences, Tokyo University of Science

Chairs: Hiroshi SATOH (Iwate University)

Koji UEDA (Faculty of Pharmacy, Meijo University)

Foods, food additives, and food contaminantsP-18E TheeffectsofCYPinhibitorsandinducersonpharmacokineticsand

toxicity of substance responsible for “Gin-nan food poisoning” (4′-O-Methylpyridoxine : MPN)○ Mika ISHIKAWA, Eri OKIMOTO, Maaya SASAKI, Ryota KONNO, Eri NAKATA, Daisuke KOBAYASHI, Teruki YOSHIMURA, Keiji WADA

School of Pharmaceutical Sciences, Health Sciences University of Hokkaido

P-19E Possible involvement of chromosome aberrations and DNA damages in acetamide-induced hepatocarcinogenesis in rats○ Kenji NAKAMURA1, 2, Yuji ISHII1, Aki KIJIMA1, Shinji TAKASU1, Takehiko NOHMI1, 2, Makoto SHIBUTANI2, Kumiko OGAWA1

1Division of Pathology, National Institute of Health Sciences, 2Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology

NanomaterialsP-22E Silver nanoparticles upregulate amyloid precursor protein in

SH-SY5Y cells○ Kazuma HIGASHISAKA1, 2, Junpei KASAHARA2, Miyuki SAKURAI2, Asato TOYODA2, Shun-ichi ETO2, Hirofumi TSUJINO2, Kazuya NAGANO2, Yasuo TSUTSUMI2, 3

1Graduate School of Medicine, Osaka University, 2Graduate School of Pharmaceutical Sciences, Osaka University, 3Global Center for Medical Engineering and Informatics, Osaka Univ.

Pro

gram

(J

une

29

, AM

)

Chairs: Kaoru SATO (Div Pharmacol, NIHS)

Tsutomu TAKAHASHI ( Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences)

Nervous systemP-28E※ DeletionofNrf2enhancessusceptibilitytoneurotoxiceffectsof

acrylamide in mice○ Frederick Adams EKUBAN1, Cai ZONG1, Madoka TAKIKAWA1, Kouta MORIKAWA1, Toshihiro SAKURAI1, Sahoko ICHIHARA2, Ken ITOH3, Masayuki YAMAMOTO4, Seiichiroh OHSAKO5, Gaku ICHIHARA1

1Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2Jichi Medical University, 3Hirosaki University, 4Tohoku University, 5The University of Tokyo

P-29E※ Neurite retraction in bioaminergic neurons induced by exposure to conditioned medium from acrylamide-treated microglial cells○ Harue SATO1, Cai ZONG1, Sho IWAMA1, Benoit SCHNEIDER2, Makoto URUSHITANI3, Gaku ICHIHARA1

1Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2University of Paris, Inserm UMR-S1124, Paris, France, 3Department of Neurology, Shiga University of Medical Science


Chairs: Katsuhiro MIYAJIMA (Tokyo University of Agriculture, Faculty of Applied Biosciences)

Masashi SEKIMOTO (School of Life and Environmental Science, Azabu University)

LiverP-36E Exploring for new biomarkers using liver organoids derived from

nonalcoholic steatohepatitis (NASH) model mice ○ Megumi YAMANAKA1, Elbadawy MOHAMED1, Kimika HAYASHI1, Yuta GOTO1, Ryouichi TSUNEDOMI2, Shoichi HAZAMA2, 3, Hiroaki NAGANO2, Toshinori YOSHIDA4, Makoto SHIBUTANI4, Ryo ICHIKAWA4, Junta NAKAHARA4, Tsutomu OMATSU5, Tetsuya MIZUTANI5, Yukie KATAYAMA5, Yuta SHINOHARA6, Masahiro KANEDA7, Hideyuki YAMAWAKI8, Tatsuya USUI1, Kazuaki SASAKI1

1Lab. Vet Pharm., Dept Vet Med., Tokyo Agri&Tech Univ., 2Dept. Gastro-Breast & Endocrine Surgery, Grad. Sch. Med, Yamaguchi Univ., 3Dept.Translational Res. & Develop. Develop. Therap. against Cancer., Sch. Med, Yamaguchi Univ., 4Lab. Vet Pathol., Dept Vet. Med., Tokyo Agri&Tech Univ., 5Res & Edu Ctr., Dept Vet Med., Tokyo Agri&Tech Univ., 6Pet Health & Food Division, Iuskura Industry, 7Lab. Vet Anatomy., Dept Vet Med., Tokyo Agri&Tech Univ., 8Lab. Vet Pharm., Dept Vet Med., Kitasato Univ.

P-37E Characterization of transgenic mice expressing human NPC1L1, an exacerbation factor of steatosis, in hepatocytes as an NAFLD model animal○ Yu TOYODA1, Tappei TAKADA1, Masakazu UMEZAWA2, Yoshihide YAMANASHI1, Ken TAKEDA3, Hiroshi SUZUKI1

1Department of Pharmacy, The University of Tokyo Hospital, 2Department of Materials Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 3Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University

Program

(J

une 29

, AM

)

P-42E AnovelmechanismofhypoglycemiceffectofadopamineD2receptoragonist Bromocriptine○ Takaya KUTSUKAKE1, Tomoyuki KISHIDA1, Ryohei YOKOI1, Shinji SOUMA2

1Toxicology, Safety Research Lab. Kissei Pharmaceutical Co., Ltd , 2Safety Research Lab. Kissei Pharmaceutical Co., Ltd

CarcinogenicityP-43E TheinfluenceofPXRactivationonlivercarcinogenesisinmice

○ Ryota SHIZU1, Mai ISHIMURA1, Sumihito NOBUSAWA2, Takuomi HOSAKA1, Takamitsu SASAKI1, Satoru KAKIZAKI2, Kouichi YOSHINARI1

1Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 2Gunma University Graduate School of Medicine

Chairs: Kazuhiro HOSOI (Santen Pharmaceutical Co., Ltd.)

Yoshiko OKAI (Takeda Pharmaceutical Company Limited)

Sensory organP-48E Results and challenges in subretinal injection in rats, rabbits,

and cynomolgus monkeys○ Megumi SAKATA, Koji KABAYAMA, Tomoaki ARAKI, Hideshi TSUSAKI

Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories (SNBL), Ltd.

Cardio vascular systemP-49E Cardiovascular evaluation in rabbits: a preliminary study toward

application to safety evaluation of ophthalmic drugs○ Miki MASATSUGU, Ikuyo ATSUMI, Yoshinori YAMAGIWA, Masaaki KURATA

Central Research Laboratories, Research & Development Division, Senju Pharmaceutical Co., Ltd.

P-50E※ Improvement of human iPSC-derived cardiomyocyte treated with subchronic electrical stimulation for evaluating the cardiotox risk○ Kaoru MORIMURA1, 3, Ayako KAMEI1, 3, Maiko OMORI1, Katsuyuki KAZUSA2, 3, Aya UEKI4

1FUJIFILM Corporation Bio Science & Engineering Laboratory, 2Astellas Pharma Inc. Drug Safety Research Laboratories, 3Consortium for Safety Assessment using Human iPS cells (CSAHi) Heart team, 4PERSOL TEMPSTAFF CO., LTD. Research and Development Tsukuba Office

Pro

gram

(J

une

29

, AM

)

Day 1 PM (June 29 (Mon))

Track 1

Workshop 1 June 29 (Mon) 14:20 - 16:20Track 1

Study on regulatory requirements for ensuring the quality and safety of the next generation typed medium molecular peptide medicine Chairs: Yoshiro SAITO (National Institute of Health Sciences)

Hideo FUKUI (Non Clinical Safety Research, Axcelead Drug Discovery Partners, Inc.)

W1-1 Preclinical safety evaluation for peptide pharmaceuticals at PMDA○ Misaki NAOTA, Kazushige MAKI


W1-2 Nonclinical toxicological evaluation for non-natural peptide therapeutics○ Hideo FUKUI

Non Clinical Safety Research, Axcelead Drug Discovery Partners, Inc.

W1-3 Points to consider in toxicological assessment for medium sized peptide drugs and impurities○ Masayuki MISHIMA

Chugai Pharmaceutical

W1-4※ Consideration for non-clinical assessment related to ADME of peptide containingnon-natural/modifiedresidues○ Teruyasu YOSHIMASA1, 2

1Japan Pharmaceutical Manufacturers Association, 2DMPK Research Labolatory, Kyorin Pharmaceutical Company Limited

W1-5※ Perspective on non-clinical evaluation of peptide drugs containing non-natural/modifiedstructures○ Yoshiro SAITO, Yosuke DEMIZU

National Institute of Health Sciences


Novel in silico/in vitro/in vivo assessment of toxicity considering drug metabolism and pharmacokinetics in humans, and the future perspectivesChairs: Seigo SANOH (Graduate School of Biomedical and Health Sciences, Hiroshima University)

Shuichi SEKINE (Shiseido Co. Ltd. Global Innovation Center)

Introduction ○ Seigo SANOH

Graduate School of Biomedical and Health Sciences, Hiroshima University


Program

(J

une 29

, PM

)

S6-1※ Current status and problems of in silico toxicity prediction based on computational toxicology○ Yoshihiro UESAWA

Meiji Pharmaceutical University, Department of Medical Molecular Informatics

S6-2※ Virtual hepatic concentrations of industrial chemicals extrapolated using pharmacokinetic models for predicting liver toxicity○ Hiroshi YAMAZAKI

Showa Pharmaceutical University

S6-3※ Mechanism-based integrated in vitro assay systems for the prediction of drug-induced liver injury○ Kousei ITO

Graduate School of Pharmaceutical Sciences, Chiba University

S6-4※ Applicationfordrugdiscoveryusingmammalianartificialchromosomes○ Yasuhiro KAZUKI

Chromosome Engineering Research Center, Tottori University

S6-5※ Assessment of drug-induced hepatotoxicity considering drug metabolism and pharmacokinetics by hepatocyte spheroids and chimeric mice with humanized liver○ Seigo SANOH


S6-6※ Evaluation and application of drug-induced toxicity using experimental animals○ Tsuyoshi YOKOI

Department of Drug Safety Sciences, Nagoya University Graduate School of Medicine

Conclusion ○ Shuichi SEKINE

Shiseido Co. Ltd. Global Innovation Center

Track 2


Genome editing technology and its safetyChair: Ryuichi ONO ( Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research (CBSR),

National Institute of Health Sciences (NIHS))

Introduction

Pro

gram

(J

une

29

, PM

)

S7-1 Development of gene therapy using genome editing technologies○ Naoto HIRAMATSU1, Eriko UCHIDA2, Naoto INUKAI1, Kenichi IWAI1, Takeshi WATANABE1, Hideyoshi KAWASAKI4, Kotaro TAMURA4, Eiji YOSHIMI4, Norihiko TAKAHASHI5, Tatsuya IHARA6, Kazunori FUJIMOTO7, Akihito YAMASHITA8, Takashi ONO6, Kan TAKAGI9, Ryuichi ONO2, Yuki NAITO3, Takao INOUE2

1Takeda Pharmaceutical Company Limited, 2National Institute of Health Sciences, 3Database Center for Life Science (DBCLS), 4Astellas Pharma Inc., 5Otsuka Pharmaceutical Co., Ltd., 6Ono Pharmaceutical Company Limited, 7Daiichi Sankyo Company Limited, 8Sumitomo Dainippon Pharma Co., Ltd., 9Mitsubishi Tanabe Pharma Corporation

S7-2 On-target risk and horizontal gene transfer in genome editing○ Ryuichi ONO

Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research (CBSR), National Institute of Health Sciences (NIHS)

S7-3 TheriskandbenefitofCRISPR/Cas9mediatedgenomeeditinginmice○ Masahito IKAWA1, 2

1Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, 2Laboratory of Reproductive System Biology, The Institute of Medical Science, The University of Tokyo

S7-4※ Evolutionofsequence-specificanti-silencingsystemsinArabidopsis○ Tetsuji KAKUTANI

The University of Tokyo

S7-5※ Evolution of skin stratum corner barrier function○ Takeshi MATSUI

Laboratory for Skin Homeostasis, RIKEN Center for Integrative Medical Sciences (IMS)


Track 3


Safety assessment strategy for anti-cancer drug-induced pulmonary toxicityChairs: Katsuyoshi CHIBA (Medicinal Safety Research Laboratories, DAIICHI SANKYO CO., LTD.)

Terufumi KATO (Kanagawa Cancer Center)

Introduction ○ Katsuyoshi CHIBA

Medicinal Safety Research Laboratories, DAIICHI SANKYO CO., LTD.

S8-1 Tentative○ Terufumi KATO

Kanagawa Cancer Center

S8-2 Radiological and pathological patterns of drug-induced lung injury○ Tomohisa BABA, Tamiko TAKEMURA, Tae IWASAWA, Takashi OGURA

Kanagawa Cardiovascular & Respiratory Center

Program

(J

une 29

, PM

)

S8-3 Pathological features and issues in preclinical lung injury models○ Kenji ADACHI

Research Division, Chugai Pharmaceutical Co., Ltd.

S8-4 Nonclinical safety assessment of trastuzumab deruxtecan (T-DXd;DS-8201),aHER2targetingantibody-drugconjugate○ Kazuyoshi KUMAGAI

Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd.

Discussion


Proposals of brand-new evaluation methods for ensuring the safety of pharmaceuticals, foods and cosmetics in humans from young researchersChairs: Kazuya NAGANO (Graduate School of Pharmaceutical Sciences, Osaka University)

Kazuya MAEDA (Graduate School of Pharmceutical Sciences, The University of Tokyo)

Introduction S9-1 Understandingofunrecognizedeffectsoflowmolecularweight

compounds by a decomposition analysis○ Tadahaya MIZUNO, Katsuhisa MORITA, Shumpei NEMOTO, Hiroyuki KUSUHARA

Molecular Pharmacokinetics, Pharmaceutical Sciences, The University of Tokyo

S9-2 Quantitative prediction of drug pharmacokinetics, pharmacological and toxicologicaleffectsusingmathematicalmodeling○ Kota TOSHIMOTO1, 2

1Sugiyama Laboratory, RIKEN, 2Analysis and Pharmacokinetics Research Labs, Drug Discovery Research, Astellas Pharma Inc.

S9-3 Current situation and problems about Good Manufacturing Practice (GMP) of health foods○ Takaaki TAGUCHI, Hiroshi AKIYAMA

Division of Foods, Natural Institute of Health Sciences

S9-4 Evaluation of safety assessments in cosmetics using non-animal testing○ Hanae KOBAYASHI

Shiseido Global Innovation Center

S9-5※ Development and evaluation of single particle ICP-MS analysis to reveal the distribution of nanoparticles in the body○ Kazuya NAGANO1, Takuya ISHIZAKA1, Ikkei TASAKI1, Hong TAO1, Hirofumi TSUJINO1, Kazuma HIGASHISAKA1, 2, Yasuo TSUTSUMI1, 3

1Graduate School of Pharmaceutical Sciences, Osaka University, 2Graduate School of Medicine, Osaka University, 3Global Center for Medical Engineering and Informatics, Osaka University

Conclusion

Pro

gram

(J

une

29

, PM

)

Track 4


JSCT-JSOT Joint Symposium: Marine toxins revisited 2.0Chairs: Manabu SUGITA (Emergency and Critical Care Medicine, Juntendo University Nerima Hospital)

Satoshi KITAJIMA ( Division of Cellular & Molecular Toxicology, Center for Biological Safety & Research, National Institute of Health Sciences )

S10-1 Evaluationofcentralnervoussystemeffectsoftetrodotoxinbymodernization of acute toxicity test○ Yuhji TAQUAHASHI1, Kentaro TANEMURA2, Ken-ichi AISAKI1, Satoshi KITAJIMA1

1Division of Cellular and Molecular Toxicology, Center for Biological Safety & Research, National Institute of Health Sciences, 2Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University

S10-2 Neurobehavioral toxicity of adult male mice induced by disturbance of neuronal signals at developmental period ~The mouse model of brain disease by marine poison part2~ ○ Kentaro TANEMURA1, Takahiro SASAKI1, Hirokatsu SAITO2, Yuhji TAQUAHASHI2, Satoshi KITAJIMA2, Jun KANNO3

1Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University, 2Division of Cellular and Molecular Toxicology, BSRC, National Institute of Health Sciences, 3National Institute of Health Sciences

S10-3 Clinicalcharacteristicsofjellyfishandstonefish“Oni-Daruma-Okoze”stings in Japan○ Joji TOMIOKA1, Toru HIFUMI2, Norio OTANI2, Nobuaki NAKAYA3, Takeshi KITAMOTO4, Yutaka KONDO5, Kentaro KOBAYASHI6, Yoshimune FUKUCHI7

1Yonemori Emergency Service, Yonemori Hospital, 2Department of Emergency and Critical Care medicine, St. Luke's International Hospital, 3Saitama Medical University Hospital, 4Department of internal medicine and psychiatry, Hasegawa Hospital, 5Department of Emergency and Critical Care Medicine, Juntendo University Urayasu Hospital, 6Department of Emergency Medicine and Critical Care, Center Hospital of National Center for Global Health and Medicine, 7Okinawa Prefectural Institute of Health and Environment

S10-4 Cyanotoxin microcystin-LR induces novel EMT-like changes to OATP1B3-expressing cells○ Masaharu KOMATSU, Shota TAKUMI

Division of Food and Chemical Biology, Faculty of Fisheries, Kagoshima University

Discussion

Program

(J

une 29

, PM

)


Seminar for researchers leading toward a new era: making toxicology greatefurtherbygroundbreakingworkfromotherresearchfieldsChairs: Mayumi ISHIZUKA (Laboratory of Toxicology, Faculty of Veterinary Medicine, Hokkaido University)

Yuhji TAQUAHASHI ( Division of Cellular and Molecular Toxicology, Center for Biological Safety & Research, National Institute of Health Sciences)

Introduction S11-1 Analysisofdrugsinhairinthefieldofforensicscience

○ Noriaki SHIMA Forensic Science Laboratory, Osaka Prefectural Police Headquarters

S11-2※ Development of the printed electrochemical biosensors for non-invasive physiological analysis○ Kuniaki NAGAMINE, Hiroyuki MATSUI, Shizuo TOKITO

Graduate School of Organic Materials Science, Yamagata University

S11-3 Toxic substance as a defensive tool of plants and its detection in insects○ Mamiko OZAKI

Department of Biology, Graduate School of Science, Kobe University

S11-4 Disease diagnosis based on the analysis of volatile metabolites○ Seung-Woo LEE

Department of Chemical Processes & Environment, The University of Kitakyushu

Conclusion

Track 5


Advance in risk assessment research for food by using new evaluation methodologiesChairs: Akihiko HIROSE (National Institute of Health Sciences)

Atsushi ONO ( Laboratory of Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University)

Introduction ○ Akihiko HIROSE


S12-1 in silico method for risk assessment of chemicals in food with trace levels○ Atsushi ONO

Laboratory of Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

Pro

gram

(J

une

29

, PM

)

S12-2 Novelapproachesforfoodsafetyriskassessment-EffortofILSIJapan○ Tomohiro KAWAGUCHI

ILSI Japan

S12-3 A new direction toward dose response analysis employing benchmark dose (BMD) method○ Hiroshi NISHIURA

Hokkaido University Graduate School of Medicine

Discussion


The 3Rs of animal welfare in nonclinical safety studies in JapanChairs: Mamoru MUTAI (LSI Medience Corporation)

Fumio SAGAMI (The Liaison Committee for Laboratory Animal Scientists)

S13-1 An overview of the Three Rs in assessing the safety of pharmaceuticals○ Hajime KOJIMA

Division of Risk Assessment, Center for Biological Safety and Research, National Institute of Health Sciences

S13-2 Approach of reduction in drug discovery research○ Toshihiko WATANABE

Chugai Pharmaceutical Co., Ltd.

S13-3 Putting“Refinement”intopractice○ Shigiko TAKEI

Ina Research Inc.

S13-4 Effortsforsocialconsensusonanimalstudiesinlifesciences○ Takehiko BANDO

Liaison Committee for Laboratory Animal Scientists

Track 6


ToxicologicalsignificanceofbiogenicnanoparticlesChairs: Yasumitsu OGRA ( Laboratory of Toxicology and Environmental Health, Graduate School of Pharmaceutical

Sciences, Chiba University)

Takafumi HIRATA (Geochemical Research Center, The University of Tokyo)

Introduction ○ Yasumitsu OGRA

Laboratory of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University

S14-1 Simultaneous imaging of nanoparticles and dissolved ions in biological tissue samples using laser ablation-plasma mass spectrometry○ Takafumi HIRATA, Shuji YAMASHITA, Masaki NAKAZATO

Geochemical Research Center, The University of Tokyo

Program

(J

une 29

, PM

)

S14-2 Mechanisms of formation of biogenic chalcogen nanoparticles in bacteria○ Hisaaki MIHARA

College of Life Sciences, Ritsumeikan University

S14-3 Formation of biogenic nanoparticles in unicellular alga○ Akiko HOKURA

Department of Applied Chemistry, School of Engineering, Tokyo Denki University

S14-4 Biogenic nanoparticles in animals and plants○ Yasumitsu OGRA


Conclusion ○ Yasumitsu OGRA


Track7


Chairs: Kazuhiro CHIHARA (Preclinical Research Unit, Sumitomo Dainippon Pharma Co., Ltd.)

Hideko SONE (Yokohama University of Pharmacy)

Reproductive and developmental toxicologyP-53E Effectofdevelopmentalexposuretoethanolonhippocampal

neurogenesis in rats○ Yasunori TAKAHASHI1, 2, Risako YAMASHITA1, Satomi KIKUCHI1, 2, Hiromu OKANO1, 2, Kazumi TAKASHIMA1, 2, Mio KOBAYASHI1, Toshinori YOSHIDA1, 2, Makoto SHIBUTANI1, 2

1Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 2Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology

P-54E Amelioratingeffectofα-glycosylisoquercitrinonbraininjurycausedbyLPS-induceddevelopmentalneuroinflammationinrats○ Hiromu OKANO1, 2, Yasunori TAKAHASHI1, 2, Kazumi TAKASHIMA1, 2, Satomi KIKUCHI1, 2, Risako YAMASHITA1, Mihoko KOYANAGI3, Shin-mo HAYASHI2, Toshinori YOSHIDA1, 2, Makoto SHIBUTANI1, 2

1LVP, TUAT, 2CDVS, TUAT, 3San-Ei Gen F.F.I., Inc.

P-55E※ Role of Death associated protein-like 1 (Dapl1) in steroidogenesis: study using Dapl1-null mice○ Hongbin CHEN1, Hiroe SANO1, Ren-shi LI2, Yukiko HATTORI1, Tomoki TAKEDA1, 3, Yoshitaka TANAKA1, Yuji ISHII1

1Graduate School of Pharmaceutical Sciences, Kyushu University , 2China Pharmaceutical University, 3Japan Bioassay Research Center

Pro

gram

(J

une

29

, PM

)

Chairs: Shuichi HAMADA (BoZo Research Center)

Shigeharu MUTO (Mitsubishi Tanabe Pharma Corporation)

Genetic toxicologyP-56E Investigation of in vivo comet assay in rabbit corneal epithelial cells

with single ophthalmic administration of genotoxic compounds○ Haruna TAHARA, Yoshinori YAMAGIWA, Miki MASATSUGU, Gen SUZUKI, Ikuyo ATSUMI, Yu HARANOSONO, Masaaki KURATA

Senju Pharmaceutical Co., Ltd. Research & Development Division

P-57E LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases○ Taiki ABE1, Ikumi UMEKI1, Shin-ichiro KANNO2, Shin-ichi INOUE1, Tetsuya NIIHORI1, Yoko AOKI1

1Department of Medical Genetics, Tohoku University School of Medicine, 2Division of Dynamic Proteome, Institute of Development, Aging, and Cancer, Tohoku University

Behavioral toxicologyP-59E Early-life exposure to low levels of permethrin exerts impairments in

learningandmemorywiththeeffectsonneuronalandglialpopulationin adult male mice○ Hirokatsu SAITO1, Kenshiro HARA2, Takashi TOMINAGA3, Kinichi NAKASHIMA4, Satoshi KITAJIMA1, Jun KANNO5, Kentaro TANEMURA2

1Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences, 2Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University, 3Laboratory for Neural Circuit Systems, Institute of Neuroscience, Tokushima Bunri University, 4Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, 5National Institute of Health Sciences


Chairs: Takumi OHISHI (Bozo Research Center Inc.)

Kiyomitsu NEMOTO (Fac. Pharm. Sci., Toho-Univ.)

ImmunotoxicologyP-60E※ IdentificationofthedogorthologueofhumanMAS-relatedGprotein

coupledreceptorX2(MRGPRX2)essentialfordrug-induced pseudo-allergic reactions○ Eri HAMAMURA, Junya MATSUSHITA, Satoshi TAMAI, Takuma IGUCHI, Noriyo NIINO, Kazuyoshi KUMAGAI, Shinobu HAKAMATA, Yoshimi TSUCHIYA, Kazuhiko MORI


P-61E Involvement of immune tolerance systems in the onset of HLA allele-specificdrug-inducedimmunotoxicity○ Shigeki AOKI, Saki KUWAHARA, Takeshi SUSUKIDA, Kousei ITO

Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University

Program

(J

une 29

, PM

)

Mechanisms of toxicityP-69E※ Characterization of human UDP-glucuronosyltransferase 1A7:

the role of Trp208 and surrounding residues○ Ryota TSUTSUMI1, Yuu MIYAUCHI1, Natsuki EGOSHI1, Peter I. MACKENZIE2, Yoshitaka TANAKA1, Yuji ISHII1

1Graduate School of Pharmaceutical Sciences, Kyushu University, 2Clinical Pharmacology, College of Medicine and Public Health, Flinders University

Cellular responseP-72E Development of novel strategies for cancer therapy by using the

inducer of the atypical cell death parthanatos○ Mayuka YAMADA, Yusuke HIRATA, Takuya NOGUCHI, Atsushi MATSUZAWA


Chairs: Hitoshi NARAOKA (Stem Cell Evaluation Technology Research Assosiation/Astellas Pharma)

Takeshi TOYODA (Division of Pathology, National Institute of Health Sciences)

BiomarkersP-77E Prediction of drug-induced convulsion by using heart rate variability in

monkeys○ Kazuhiro KUGA1, Shoya NAGATA2, Chikao NAKAYAMA3, Harushige OZAKI1, Koichi FUJIWARA2

1Takeda Pharmaceutical Company Limited, 2Nagoya University, 3Kyoto University

P-79E Detection of drug-induced vasculitis using in vivo MRI○ Yuta FUJII1, Yuka YOSHINO1, Yasuaki UEMATSU1, Aya NAKAE2, Junichiro ENMI2, Yoshichika YOSHIOKA2, Izuru MIYAWAKI1

1Preclinical Reserch Unit, Sumitomo Dainippon Pharma Co., Ltd. , 2Graduate School of Frontier Biosciences, Osaka University

P-80E※ IdentificationofmicroRNAsassociatedwithcleftpalate○ Hiroki YOSHIOKA, Aimin LI, Zhonming ZHAO, Junichi IWATA

The University of Texas Health Science at Houston

Pro

gram

(J

une

29

, PM

)


Chairs: Yumi AKAHORI (Chemicals Evaluation and Research Institute (CERI), Japan)

Tomoki FUKUYAMA (Laboratory of Veterinary Pharmacology, Azabu University)

Toxicity-testing methodsP-81E Establishment of 2.5D organoid culture model using 3D bladder cancer

organoid ○ Kimika HAYASHI1, Amira ABUGOMAA1, 2, Mohamed ELBADAWY1, 3, Megumi YAMANAKA1, Yuta GOTO1, Takashi MORI4, 5, Tsuyoshi UCHIDE6, Daigo AZAKAMI7, Ryuji FUKUSHIMA8, Toshinori YOSHIDA9, Makoto SHIBUTANI9, Risako YAMASHITA9, Hideyuki YAMAWAKI10, Yuta SHINOHARA1, 11, Masahiro KANEDA12, Tatsuya USUI1, Kazuaki SASAKI1

1Laboratory of Veterinary Pharmacology, Department of Veterinary, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 2Faculty of Veterinary Medicine, Mansoura University, 3Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 4Laboratory of Veterinary Clinical Oncology, Faculty of Applied Biological Sciences, Gifu University, 5Center for Highly Advanced Integration of Nano and Life Sciences, Gifu University, 6Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 7Department of Veterinary Clinical Oncology, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 8Animal Medical Center, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 9Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 10Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, 11Pet Health & Food Division, Iskara Industry CO., LTD, 12Laboratory of Veterinary Anatomy, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology,

P-83E Optimization of assessment method for drug induced contractile response in human induced pluripotent stem cell-derived cardiac cell sheet-tissue○ Eriko KATO1, Yuto HINATA2, Yuki KAGAWA2, Hirotsugu KUBO2, Tomohiko TANIGUCHI3, Takashi YOSHINAGA3, Atsushi BABA1, Yuji IKEGAYA1, Kohei SAWADA1

1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2Ogino Memorial Laboratory, Nihon Kohden Corporation, 3Advanced Biosignal Safety Assessment, Eisai Co., Ltd.

Alternatives to mammalian modelsP-85E A novel strategy combining Kao ITS and read-across to determine the

skin sensitization potency of cosmetic ingredients○ Kanako NAKAYAMA1, Anne GRANITZNY2, Sabrina FRITZ2, Anne FUCHS2, Masaaki MIYAZAWA1, Hitoshi SAKAGUCHI1

1Kao Corporation, Safety Science Research, 2Safety & Toxicology, Kao Germany GmbH

P-87E Integrated approaches to testing and assessment to assess photosensitization potential ~Establishment of photo-DPRA~○ Toshiyuki OHTAKE, Hayato NISHIDA, Morihiko HIROTA, Hirokazu KOUZUKI


Program

(J

une 29

, PM

)

Chairs: Atsushi ONO ( Laboratory of Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University)

Yuji ISHII (National Institute of Health Sciences)

Alternatives to mammalian modelsP-88E Application to prediction for respiratory sensitization using in chemico

Amino acid Derivative Reactivity Assay (ADRA) having developed for skin sensitization○ Sayaka WANIBUCHI, Yusuke YAMAMOTO, Toshihiko KASAHARA, Yasuhiro KATSUOKA, Masaharu FUJITA

Safety Evaluation Center, Ecology&Quality Management Division, ES G Division, Kanagawa, Japan

P-89E Examination of an internal threshold of toxicological concern (iTTC) for cosmetic use in the systemic toxicity assessment○ Takumi NUKAGA, Shuichi SEKINE, Tomoka HISAKI, Koki YOSHIDA, Takeshi HARIYA, Hirokazu KOZUKI

Safety and Analytics Center, SHISEIDO Global Inovation Center

P-90E Validation studies of IATA based read-across for developing alternative method of systemic toxicity○ Shota NAKAGAWA, Maiko OKAMOTO, Keita YOSHIHARA, Yuuko NUKADA, Osamu MORITA

Kao Corporation, Safety Science Research

P-91E ZebrafishembryodevelopmentaltoxicitytestusingICHS5referencecompounds -Investigation of the cause of false negative judgment by measuring the concentration in the embryo-○ Tasuku NAWAJI1, 2, Kaho MURAKAMI1, Takashi KURAKU1, Takeshi MATSUURA1, Masanori SEKI1, Hiroki TERAOKA2

1Chemicals Evaluation and Research Institute, Japan, 2School of Veterinary Medicine, Rakuno Gakuen University

Pro

gram

(J

une

29

, PM

)

Day 2 AM (June 30 (Tue))

Track 1

Workshop 2 June 30 (Tue) 9:00 - 11:30Track 1

CaseStudiesandRecentTopicsinTargetProfilingforDrugSafetyChairs: Akinobu OKADA (Research Planning & Administration, Astellas Pharma inc.)

Hisaharu YAMADA (Senior Specialists' Office, Pharmaceutical Product, Taisho Pharmaceutical Co., Ltd.)

Introduction ○ Hisaharu YAMADA

Senior Specialists' Office, Pharmaceutical Product, Taisho Pharmaceutical Co., Ltd.

W2-1 Approach to mitigate on-target toxicity using knock out animals and in vitro assay system at exploratory phase○ Ryo WATANABE

Medicinal Safety Research Laboratories, Daiichi Sankyo Co., LTD.

W2-2 Targetprofilingoftoxicologicalfindingsinsmallmoleculardrugdevelopments○ Kyotaka MUTA

Toxicology Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc.

W2-3※ Case studies of target-mediated toxicity in antibody drug discovery○ Sho AKAI

Translational Research Division, Chugai Pharmaceutical Co., Ltd.

W2-4 Practiceofoff-targetanalysisofnucleicaciddrugsandgenomeeditingdrugs○ Ko OMURA

Advanced Safety Technology, Drug Safety Research Labs., Astellas Pharma Inc.

Conclusion ○ Akinobu OKADA

Research Planning & Administration, Astellas Pharma inc.

Track 2

Educational Lecture June 30 (Tue) 9:00 - 10:00Track 2

Chair: Yasushi YAMAZOE (Tohoku University/National Institute of Health Sciences)

EL Cellular adaptation in toxicology○ Curtis D. KLAASSEN

Department of Pharmacology and Toxicology, University of Kansas, USA


Program

(J

une 30

, AM

)

Special Panel Discussion June 30 (Tue) 10:10 - 11:10Track 2

Cross-talk between adduct exposome and epigenomeChair: Takashi UEHARA ( Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry,

and Pharmaceutical Sciences, Okayama University)

PD-1※ A modeling of restricted exposome for chemicals with protein-modifying capability○ Yoshito KUMAGAI

Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba

PD-2※ Epigeneticregulationviaproteinmodificationbyenvironmentalelectrophiles○ Takashi UEHARA

Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University

PD-3※ Newdevelopmentsonlysineacylmodificationresearch-Possibilityoflysine adduct exposome by food constituent carboxylic acids-○ Akihiro ITO

Laboratory of Cell Signaling, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science

Special Lecture 3 June 30 (Tue) 11:20 - 12:20Track 2

JSOT-KSOT Exchange Promotion ProgramChair: Yoshito KUMAGAI (Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba)

SL3※ Elucidation of novel molecular mechanisms involved in the reduction of methylmercury toxicity by using metabolomic analysis○ Gi-Wook HWANG

Laboratory of Environmental and Health Sciences, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University

Track 3

Symposium 15 June 30 (Tue) 9:00 - 10:00Track 3

Safetyasessmentforregenerativemedicine:Influenceofgenomeediting Chairs: Hideo FUKUI (Non Clinical Safety Research, Axcelead Drug Discovery Partners, Inc.)

Kazushige MAKI (Pharmaceuticals and Medical Devices Agency)

S15-1 Currentissuesonreflectionpaperforgenomeeditinggenetherapy○ Teruhide YAMAGUCHI1, 2

1Kanazawa Institute of Technology, 2Nihon Pharmaceutical University

Pro

gram

(J

une

30

, AM

)

S15-2 Preclinical consideration for gene-edited cellular products at PMDA○ Kazushige MAKI


Special Lecture 4 June 30 (Tue) 10:10 - 11:10Track 3

Chair: Ikuo HORII (Pfizer)

SL4※ Preclinical safety assessments of gene therapy products○ Michael W. BOLT1, Joseph T. BRADY1, Laurence O. WHITELEY1, K. Nasir KHAN2

1Pfizer, Drug Safety Research and Development, Cambridge, MA, USA, 2Pfizer, Drug Safety Research and Development, Groton, CT, USA

Track 4


Reproductive and developmental toxicity and placental functionChairs: Kazuhiro SHIMOMURA (Vaccine Research Laboratories, DAIICHI SANKYO CO., LTD.)

Satoshi FURUKAWA ( Toxicology & Environmental Science Department, Biological Research Laboratories, Nissan Chemical Corporation)

Introduction ○ Kazuhiro SHIMOMURA

Vaccine Research Laboratories, DAIICHI SANKYO CO., LTD.

S16-1 Chemical-induced histopathological changes of rat placenta○ Satoshi FURUKAWA

Toxicology & Environmental Science Department, Biological Research Laboratories, Nissan Chemical Corporation

S16-2 Placental barrier: Drug transfer mechanism and its species diferences○ Masatoshi TOMI, Saki NOGUCHI, Tomohiro NISHIMURA

Division of Pharmaceutics, Faculty of Pharmacy, Keio University

S16-3 Immunotoxicityintheplacenta:Theroleofinflammasomeonpregnancy complications○ Koumei SHIRASUNA

Tokyo University of Agriculture

S16-4※ Reproductive and developmental toxicity in a humanized-transgenic mouse with human placental endocrine function○ Tsuyoshi NAKANISHI

Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University

Program

(J

une 30

, AM

)

Track 5


Forefront of in silico exposure analysis: Human and EnvironmentChairs: Hiroshi HONDA (Kao Corporation)

Hiroshi YAMAZAKI (Showa Pharmaceutical University)

W3-1※ Introduction and a new development of environmental exposure analysis models○ Hiroshi HONDA

Kao Corporation

W3-2 Current status and future view of marine plastic pollution research○ Atsuhiko ISOBE

Research Institute for Applied Mechanics, Kyushu University

W3-3※ Physiologically-Based Pharmacokinetic (PBPK) modeling in toxicology○ Hiroshi YAMAZAKI

Showa Pharmaceutical University

W3-4 A new strategy of pharmacokinetic analysis - Complete integration of top-down and bottom-up approaches -○ Akihiro HISAKA

Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University

W3-5 DruMAP: an integrated analysis platform for drug metabolism and pharmacokinetics○ Kenji MIZUGUCHI1, 2

1Artificial Intelligence Center for Health and Biomedical Research (ArCHER), National Institutes of Biomedical Innovation, Health and Nutrition, 2Institute for Protein Research, Osaka University

Discussion

Track 6


Challenges and countermeasures towards globalization of the assessment procedures of developmental neurotoxicity induced by low dose/low concentration chemical exposureChairs: Jun KANNO (National Institute of Health Sciences)

Kentaro TANEMURA ( Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University)

Introduction ○ Jun KANNO


Pro

gram

(J

une

30

, AM

)

S17-1 Mechanistic background of the developmental neurotoxicity testing methods and the international trends of the testing strategies○ Jun KANNO


S17-2 Emotional/cognitive behavioral toxicity induced by exposure of low dosed chemical substances during developmental stage ~Approach to the improvement of global assessment methods for neurodevelopmental toxicology~○ Kentaro TANEMURA1, Hirokatsu SAITO2, Yusuke FURUKAWA3, Ken-ichi AISAKI2, Satoshi KITAJIMA2, Jun KANNO3

1Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University, 2Division of Cellular and Molecular Toxicology, BSRC, National Institute of Health Sciences, 3National Institute of Health Sciences

S17-3 VSD imaging method to assess the vulnerability of neural circuit function○ Takashi TOMINAGA, Yoko TOMINAGA

Institute of Neuroscience, Tokushima Bunri University

S17-4 Percellome Project on Sick-Building-Syndrome level inhalation for the prediction of neurobehavioral toxicity due to several indoor volatile organic compounds○ Satoshi KITAJIMA1, Kentaro TANEMURA2, Jun KANNO3

1Division of Cellular & Molecular Toxicology, Center for Biological Safety & Research, National Institute of Health Sciences, 2Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University, 3National Institute of Health Sciences

S17-5 Potential application of postnatal and adult neurogenesis in the olfactory bulb to test developmental neurotoxicity○ Itaru IMAYOSHI

Laboratory of Brain Development and Regeneration, The Graduate School of Biostudies, Kyoto University

S17-6 Cerebellar granule cell development and evaluation of drug exposureSatoshi MIYASHITA, ○ Mikio HOSHINO

Nat'l Inst of Neurology and Psychiatry (NCNP)


○ Jun KANNO National Institute of Health Sciences

Program

(J

une 30

, AM

)

Track 7


Expectations for revised GMP ministerial ordinance to prevent cross-contamination at pharmaceutical manufacturing sitesChairs: Ichiro TSUNENARI (Nippon Boehringer Ingelheim Co.,Ltd.)

Shinichiro MATSUNAGA (Takeda Pharmaceutical Company Limited)

Introduction W4-1 GMP requirements for preventing cross-contamination based on the

toxicological evaluation○ Morihiko TAKEDA

Pharma Solutions Co., Ltd.

W4-2 Perspectives on setting PDEs in the US and Europe○ Robert G SUSSMAN

SafeBridge Consultants, Inc., USA

Panel Discussion Kiyohiro HASHIMOTO (Takeda Pharmaceutical Co., Ltd.), Chairs and Speakers

Conclusion

Pro

gram

(J

une

30

, AM

)

Day 2 PM (June 30 (Tue))

Track 1

Award Lecture June 30 (Tue) 14:30 - 16:35Track 1

The JSOT AwardChair: Mamoru MUTAI (LSI Medience Corporation)

AWL1 Research on development of in vivo rapid screening tools for detection of developmental neurotoxicity and prediction of carcinogenicity○ Makoto SHIBUTANI

Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology

The Tetsuo Satoh AwardChair: Akira NAGANUMA (Tohoku University)

AWL2 Practice of basic education for personnel engaged in toxicity studies and its introduction to The Japanese Society of Toxicology and establishmentofaqualificationsystem:Expansionoftheintegratedrisk assessment○ Mamoru NOMURA

Ina Research Inc.

The JSOT Young Scientist Award 1Chair: Naohito KAWASAKI (Laboratory of Public Health, Faculty of Pharmacy, Kindai University)

AWL3 Evaluation of the removal capability of toxic substances from the water environment and the prevention of disease○ Fumihiko OGATA

Faculty of Pharmacy, Kindai University

The JSOT Young Scientist Award 2Chair: Isao HOZUMI (Laboratory of Medical Therapeutics and Molecular Therapeutics, Gifu Pharmaceutical University)

AWL4 Study on the mechanisms of toxicity in the next generation due to fetal exposure to chemicals○ Hisaka KURITA

Laboratory of Medical Therapeutics and Molecular Therapeutics, Gifu Pharmaceutical University

The JSOT Young Scientist Award 3Chair: Yaichiro KOTAKE (Graduate School of Biomedical and Health Sciences, Hiroshima University )

AWL5 Endocrine-disruptingeffectsofbisphenolA(BPA)anditsrelatedcompounds: Studies focusing on the interactions between bisphenols andestrogenreceptorβ(ERβ)○ Masayo HIRAO-SUZUKI

Faculty of Pharmaceutical Sciences, Hiroshima International University (HIU)


Program

(J

une 30

, PM

)

Track 2


New challenges for drug safety evaluation using the in vivo imaging technologyChairs: Izuru MIYAWAKI (Preclinical Research Unit, Risearch Division, Sumitomo Dainippon Pharma Co., Ltd.)

Ken-ichiro NAN-YA (Toxicological Research Laboratories, Translational Research Unit, Kyowa Kirin Co., Ltd.)

W5-1 Introduction○ Izuru MIYAWAKI

Preclinical Research Unit, Risearch Division, Sumitomo Dainippon Pharma Co., Ltd.

W5-2 In vivo evaluation of biological function and pathology in liver and kidney by nuclear medicine imaging (PET and SPECT)○ Nozomi TAKAI

Biomarker R&D Department, Shionogi & Co., Ltd.

W5-3 Challenge for evaluating systemic toxicity using imaging modality -ApplicationofMRIforprofilingskeletalmuscleinjury-○ Katsuyuki KAZUSA

Drug Safety Research Laboratories, Astellas Pharma Inc.

W5-4 Evaluation of rodent toxicity using MRI: fatty liver and vasculitis○ Yuta FUJII1, Yuka YOSHINO1, Yasuaki UEMATSU1, Aya NAKAE2, Junichiro ENMI2, Yoshichika YOSHIOKA2, Izuru MIYAWAKI1


W5-5 Application of CT and MRI for safety evaluation in large animal○ Shota FUKAKUSA, Yosuke NUMATA, Hideshi TSUSAKI

Shin Nippon Biomedical Laboratories, Ltd.

Discussion

Track 3


Have DILI risks been avoided by various in vitro screening studies performed during the early stage of the drug development ? Chairs: Hideo FUKUI (Non Clinical Safety Research, Axcelead Drug Discovery Partners, Inc.)

Kazuhiko MORI (Daiichi Sankyo Co., Ltd. Medicinal safety research laboratories)

S18-1 Case study: Retrospective study of fasiglifam - Is in vitro screening study a strong tool to avoid DILI risk?○ Hideo FUKUI

Non Clinical Safety Research, Axcelead Drug Discovery Partners, Inc.

Pro

gram

(J

une

30

, PM

)

S18-2※ Invitroriskprofilingofdrug-inducedliverinjury(DILI)inexploratorystages of drug development and retrospective evaluation of the drugs○ Mahoko ASAYAMA1, Masamitsu ANDO2, Jun HASEGAWA1

1Safety Research Laboratories, Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2Discovery Technology Laboratories, Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation

S18-3 Prediction of drug-induced liver injury (DILI) using in vitro evaluation systems at early preclinical stage in drug development○ Kazunori FUJIMOTO


S18-4※ Retrospective analysis of the in vitro screening process for detecting DILI liability using Takeda legacy compounds○ Makoto MIYAMOTO1, Yuichiro AMANO1, Hisashi ANAYAMA1, Yvonne P DRAGAN2

1Drug Safety Research and Evaluation, Takeda Pharmaceutical Company Limited, 2Drug Safety Research and Evaluation, Takeda Pharmaceuticals International, Inc.

S18-5※ Evaluation of idiosyncratic drug-induced liver injury based on human in vitro systems○ Toru USUI

Sumitomo Dainippon Pharma Co.,LTD.

Track 4


Approches to elucidate the mechanisms involved in the methylmercury toxicityChairs: Toshiyuki KAJI ( Department of Environmental Health, Faculty of Pharmaceutical Sciences,

Tokyo University of Science)

Gi-Wook HWANG ( Laboratory of Environmental and Health Sciences, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University)

Introduction ○ Toshiyuki KAJI

Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science

S19-1※ Methylmercury toxicity and autophagy○ Masako KIYONO, Ryosuke NAKAMURA, Yuka OHSHIRO, Shimpei URAGUCHI, Yasukazu TAKANEZAWA

Department of Public Health, School of Pharmacy, Kitasato University

S19-2※ The mechanism of methylmercury-induced peripheral neurotoxicity in rat○ Yo SHINODA1, Yuta YAMADA1, Yayoi TSUNEOKA1, Tsutomu TAKAHASHI1, Eiko YOSHIDA2, Toshiyuki KAJI2, Yasuyuki FUJIWARA1

1Department of Environmental Hearth, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 2Department of Environmental Hearth, Faculty of Pharmaceutical Sciences, Tokyo University of Science

Program

(J

une 30

, PM

)

S19-3 Methylmercury-inducedneuronalhyperactivationandsite-specificneurodegeneration○ Masatake FUJIMURA1, Fusako USUKI2

1National Institute for Minamata Disease, 2Joint Research Center for Human Retrovirus Infection

S19-4※ Reactive sulfur species to regulate methylmercury toxicity○ Yoshito KUMAGAI


S19-5※ Novel signaling pathway related to methylmercury toxicity○ Gi-Wook HWANG1, 2

1Graduate School of Pharmaceutical Sciences, Tohoku University, 2Laboratory of Environmental and Health Sciences, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University

Conclusion ○ Gi-Wook HWANG

Laboratory of Environmental and Health Sciences, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University

Track 5


Frontiers of Cardiotoxicology Using iPS-derived CardiomyocytesChairs: Motohiro NISHIDA (Kyushu University, Graduate School of Pharmaceutical Sciences)

Yasunari KANDA (Division of Pharmacology, National Istitute of Health Sciences)

Introduction S20-1※ Development of cardiovascular toxicity testing for anti-cancer agents

using human iPS cell technology○ Yasunari KANDA

Division of Pharmacology, National Istitute of Health Sciences

S20-2※ Cell-to-cell variations of human iPS-derived cardiomyocytes○ Junko KUROKAWA, Momoka NAKAGAWA, Gen IGARASHI, Masahiko YAMAGUCHI, Kazuho SAKAMOTO

Department of Bio-Informational Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka

S20-3※ Cardiotoxicity risk assessment using in silico model of iPS cell-derived cardiomyocyte○ Takashi ASHIHARA

Department of Medical Informatics and Biomedical Engineering, Shiga University of Medical Science

S20-4※ Establishment of pathological models using iPS cell-derived cardiomyocytes and their application to drug discovery and toxicity tests○ Yoshinori YOSHIDA

Center for iPS Cell Research and Applicaiton, Kyoto University

Conclusion

Pro

gram

(J

une

30

, PM

)

Track 6


Accuracy control in application of Epigenetics analysis and AI to ToxicOmicsChairs: Masatoshi HAGIWARA ( Department of Anatomy and Developmental Biology, Graduate School of Medicine,

Kyoto University)

Jun KANNO (National Institute of Health Sciences)

S21-1※ Comprehensive evaluation of pseudo exonic splicing mutations for drug development○ Masatoshi HAGIWARA

Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University

S21-2 Towards an optimal dose of AI in biomedicine and healthcare○ Samik GHOSH, Takeshi HASE, Ayako YACHIE, Sucheendra Kumar PALANIAPPAN

The Systems Biology Institute, Japan

S21-3 Knowledge extraction from omics data by analytical tools and its quality control○ Yayoi NATSUME

National Institutes of Biomedical Innovation, Health and Nutrition

S21-4 AccuracycontrolofPercellomeToxicogenomicsdataanditsinfluenceon the data analysis○ Jun KANNO1, Satoshi KITAJIMA2, Ken-ichi AISAKI2, Ryuichi ONO2

1National Institute of Health Sciences, 2Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences

S21-5※ Genome-widechangesinhistonemodificationbyrepeatedadministration of chemicals○ Ryuichi ONO, Ken-ichi AISAKI, Satoshi KITAJIMA, Jun KANNO

National Institute of Health Sciences (NIHS)

Track7

Oral Session 1 June 30 (Tue) 14:30 - 15:18Track 7

Chairs: Daigo SUMI (Faculty of Pharmaceutical Sciences, Tokushima Bunri University)

Yasuhiro SHINKAI (Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba)

Metals / Environmental pollutantsO-1 Cadmium renal toxicity through the decrease in ATP level induced by

the suppression of gene expression of GLUT4○ Jin-Yong LEE, Maki TOKUMOTO, Masahiko SATOH

Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University

Program

(J

une 30

, PM

)

O-2 Intracellular demethylation of methylmercury to inorganic mercury by MerB induces autophagy○ Yasukazu TAKANEZAWA1, Ryousuke NAKAMURA1, Yuka OHSHIRO1, Shimpei URAGUCHI1, Tatsumi ADACHI2, Masako KIYONO1

1Department of Public Health, School of Pharmacy, Kitasato University, 2Faculty of Pharmacy, Chiba Institute of Science

Food additivesO-3 Molecular mechanisms and pathological consequences of the

pro-senescenceeffectsoftrans-fatty acids○ Yusuke HIRATA, Aya INOUE, Ryo ASHIDA, Takuya NOGUCHI, Atsushi MATSUZAWA


General toxicologyO-4 Development of a wearable pulse oximeter device measuring SpO2,

heart rate and respiratory rate from conscious and unrestrained rats○ Yusuke OKUBO1, Umihiro KAMOTO2, Yuhji TAQUAHASHI1, Satoshi KITAJIMA1, Hiroki OTA3

1Division of Cellular and Molecular Toxicology, Biological Safety and Research Center, National Institute of Health Sciences, 2Department of Mechanical Engineering, Yokohama National University, 3Graduate School of System Integration, Yokohama National University

Oral Session 2 June 30 (Tue) 16:00 - 17:00Track 7

Chairs: Makiko KUWAGATA (National Institute of Health Sciences)

Satoshi FURUKAWA ( Toxicology & Environmental Science Department, Biological Research Laboratories, Nissan Chemical Corporation)

Endocrine disruptorsO-5 Establishment of reporter assay yeast strain for detecting ligands of

Daphnia magna juvenile hormone receptor via upstream E-box and E-box-like elements of the Vrille gene○ Sayoko ITO-HARASHIMA1, Masahiro OGAWA1, 2, Takahiro KYOYA2, Megumi TERADA2, Masanobu KAWANISHI1, Takashi YAGI1

1Department of Biological Science, Graduate School of Science, Osaka Prefecture University, 2Life Science Research Institute, Kumiai Chemical Industry Co. Ltd.

O-6 Role of reactive oxygen species in cholangiocarcinoma induced by exposure to 1,2-dichloropropane in humans○ Abigail EKUBAN1, Cai ZONG1, Sahoko ICHIHARA2, Seiichiroh OHSAKO3, Gaku ICHIHARA1

1Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan, 2Jichi Medical University School of Medicine, Shimotsuke, Japan, 3Laboratory of Environmental Health Sciences, Faculty of Medicine, The University of Tokyo, Japan

Reproductive and developmental toxicologyO-7 Establishment of External Genitalia tissue slice culture system:

Application as an evaluation system for anti-androgenic action○ Kentaro SUZUKI, Alvin ACEBEDO, Mellissa ALCANTARA, Daiki KAJIOKA, Mizuki KAJIMOTO, Gen YAMADA

Institute of Advanced Medicine, Wakayama Medical University (WMU)

Pro

gram

(J

une

30

, PM

)

O-8 By changing the antineoplastic drug doxorubicin to its liposomal formulation, fetal toxicity is reduced○ Satoshi KITAOKA, Wataru OCHIAI

Department of Pharmacokinetics, School of Pharmaceutical Sciences, Hoshi University

ImmunotoxicologyO-9 Biased polarization of immature thymic T cells during

dexamethasone-induced thymic involutionNurhanani RAZALI, Hirofumi HOHJOH, Kimie NAKAGAWA, ○ Hiroshi HASEGAWA

Laboratory of Hygienic Sciences, Kobe Pharmaceutical University

Program

(J

une 30

, PM

)

Day 3 AM (July 1 (Wed))

Track 1

Symposium 22 July 1 (Wed) 9:00 - 11:30Track 1

MEASURE: A Multisite Collaborative Study on Tumorigenicity Assessment of Cell Therapy Products —Final Report—Chairs: Yoji SATO (Division of Cell-Based Therapeutic Products, National Institute of Health Sciences)

Hiroto BANDO (Pharmaceutical Products Division, FUJIFILM Corporation)

Introduction S22-1 Introduction of MEASURE (Multisite Evaluation study on Analytical

methods for non-clinical Safety assessment of hUman-derived REgenerative Medical Products)and its collaboration with global stakeholders○ Yoji SATO

Division of Cell-Based Therapeutic Products, National Institute of Health Sciences

S22-2 MEASURE: In vivo study for detection of tumorigenic cells contained in cell therapy products ○ Naoko TANAKA

Evaluation Center, TERUMO CORPORATION

S22-3 MEASURE: In vitro studyfordetectionofresidualundifferentiatedpluripotent stem cells: (1) Droplet Digital PCR Assay (ddPCR)○ Akihiko AZUMA

Bio Science & Engineering Laboratory, FUJIFILM Corporation

S22-4 MEASURE: In vitro studyfordetectionofresidualundifferentiatedpluripotentstemcells:(2)HighlyEfficientCultureAssay○ Takeshi WATANABE

Drug Safety Research and Evaluation, Takeda Pharmaceutical Company Limited

S22-5 MEASURE: In vitro detection of transformed cells - Cellular immortality testing -○ Norihiko SHIRAISHI

R&D Planning Department, R&D Division, Kyowa Kirin Co., Ltd.

S22-6 MEASURE: In vitro study for detection of transformed cells: (2) Digital Soft Agar Colony Formation (DSACF) Assay○ Kiyoko BANDO

Sumitomo Dainippon Pharma Co., Ltd.

S22-7※ MEASURE: Non-Clinical Study for Biodistribution Evaluation in Cell Therapy Products○ Yoshiteru KAMIYAMA

Analysis & Pharmacokinetics Research Labs., Astellas Pharma Inc.

Conclusion


Pro

gram

(J

uly

1, A

M)

Track 2


JSOT-SOT Exchange Promotion ProgramChairs: George DASTON (Victor Mills Society Research Fellow, Procter & Gamble Company, USA)

Akihiko HIROSE (National Institute of Health Sciences)

S23-1 Predicting toxicity using computation and biotechnology○ George P DASTON

Procter & Gamble, USA

S23-2 How "big" should the data be to make an impact in toxicology? Learnings from disaster research○ Ivan RUSYN

Texas A&M University, USA

S23-3 Current and future application of PERCELLOME database as a part of big data to toxicological research○ Ken-ichi AISAKI1, Takeshi HASE2, Satoshi KITAJIMA1, Ryuichi ONO1, Hiroaki KITANO2, Jun KANNO3

1Division of Cellular and Molecular Toxicology, BSRC, National Institute of Health Sciences, 2The Systems Biology Institute, 3National Institute of Health Sciences

S23-4 Tohoku Medical Megabank Project for future medicine and toxicology○ Masayuki YAMAMOTO1, 2

1Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2Tohoku Medical Megabank Organization, Tohoku University

Track 3


Drug Safety research integrating engineering approachChairs: Seiichi ISHIDA (National Institute of Health Sciences)

Tadahiro SHINOZAWA ( Global Drug Safety Research and Evaluation, Research, Takeda Pharmaceutical Company Limited)

Introduction S24-1 Application of cryoEM technology to safety

○ Kazuko YONEMORI Drug Safety Research and Evaluation, Research, Takeda Pharmaceutical Company Limited

S24-2 Development of an organ-on-a-chip that mimics retinal diseases○ Hirokazu KAJI1, 2

1Graduate School of Engineering, Tohoku University, 2Graduate School of Biomedical Engineering, Tohoku University

Program

(J

uly 1, A

M)

S24-3※ A new approach for studying steatohepatitis in humans with pluripotent stem cell-derived liver organoid system and biophysical analysis of fibrosis○ Yosuke YONEYAMA1, Takanori TAKEBE1, 2, 3

1Institute of Research, Tokyo Medical and Dental University, 2Division of Gastroenterology, Hepatology and Nutrition, Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3The Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center

S24-4※ Micromachine · MEMS for biochemical analysis○ Satoshi KONISHI

Ritsumeikan University

Track 4


On the Cutting-edge technology of Liquid Biopsy for Toxicology ReserchChairs: Mayumi ISHIZUKA (Laboratory of Toxicology, Faculty of Veterinary Medicine, Hokkaido University)

Yuhji TAQUAHASHI ( Division of Cellular and Molecular Toxicology, Center for Biological Safety & Research, National Institute of Health Sciences)

Introduction ○ Mayumi ISHIZUKA

Laboratory of Toxicology, Faculty of Veterinary Medicine, Hokkaido University

S25-1 Clinical implementation of liquid biopsy in solid cancer○ Kazuto NISHIO, Kazuko SAKAI

Department of Genome Biology, Kindai University Faculty of Medicine

S25-2 Nanobiodevices, AI, and quantum technology for liquid biopsy○ Yoshinobu BABA1, 2

1Department of Biomolecular Engineering, Nagoya University, 2Institute of Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology

S25-3※ Salivary biomarkers in point-of-care testing○ Masaki YAMAGUCHI

Graduate School of Medicine, Science, and Technology, Shinshu University

S25-4 Development of novel SPE spin column using monolithic silica for analysis of drugs from biological sample○ Shigenori OTA, Yuko YUI, Tsutomu SATO

GL Sciences Inc.

Conclusion ○ Yuhji TAQUAHASHI

Division of Cellular and Molecular Toxicology, Center for Biological Safety & Research, National Institute of Health Sciences

Pro

gram

(J

uly

1, A

M)

Track 5


JSTP-JSOT Joint Symposium: Topics from the Society of Toxicological Pathology:ToxicologicPathologyfortheEvaluationofDiversifiedModalitiesChairs: Kosei INUI (Ishihara Sangyo Kiasha, Ltd.)

Kumiko OGAWA (Pathology, National Institute of Health Sciences)

S26-1 Role of pathology in toxicology assessment○ Hiroshi ONODERA


S26-2※ Common histopathologic lesions in oligonucleotide therapeutics○ Shunji NAKATSUJI

Pathology Services, Altasciences Preclinical Seattle

S26-3※ Pathological points to consider for development of antibody therapeutics○ Atsuhiko KATO

Chugai Pharmaceutical Co., Ltd., Research Div.

S26-4※ Current status and issues of the safety evaluation in human cell derived tissue-engineered medical products○ Hiroaki MAGOTANI

Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.

Discussion

Track 6

Special Lecture 5 July 1 (Wed) 9:00 - 9:45Track 6

Chair: Akira NAGANUMA (Tohoku University)

SL5 Toxicology in human populations○ Chiho WATANABE

National Institute for Environmental Studies

Program

(J

uly 1, A

M)

Workshop 6 July 1 (Wed) 10:00 - 12:00Track 6

Signal Toxicology of Heavy MetalsChairs: Toshiyuki KAJI ( Department of Environmental Health, Faculty of Pharmaceutical Sciences,

Tokyo University of Science)

Chika YAMAMOTO (Faculty of Pharmaceutical Sciences, Toho University)

Introduction ○ Toshiyuki KAJI

Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science

W6-1 Concept of the Signal Toxicity and its expansion to the metal toxicology○ Jun KANNO


W6-2 Signal transduction pathways associated with protection against environmental electrophiles and its regulation by reactive sulfur species○ Yasuhiro SHINKAI, Yoshito KUMAGAI


W6-3※ Signal toxicology of organotin via decreased activity of transcription factor ○ Yaichiro KOTAKE


W6-4※ Mechanism of MeHg-evoked neuronal toxicity via ER stress○ Takashi UEHARA

Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University

W6-5 Intracellular glucose metabolic pathway involved in arsenite toxicity○ Tsutomu TAKAHASHI1, 2, Gi-Wook HWANG2, Akira NAGANUMA2, Yasuyuki FUJIWARA1

1Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 2Graduate School of Pharmaceutical Sciences, Tohoku University

Conclusion ○ Chika YAMAMOTO

Faculty of Pharmaceutical Sciences, Toho University

Pro

gram

(J

uly

1, A

M)

Track 7

Oral Session 3 July 1 (Wed) 9:00 - 10:12Track 7

Chairs: Masahiro TOHKIN (Graduate School of Pharmaceutical Sciences, Nagoya City Universi)

Fumiyo SAITO ( Division of Veterinary Medicine, Faculty of Veterinary Medicine, Okayama University of Science (OUS))

Mechanisms of toxicityO-10 Analysis of Japanese and US adverse event report databases favor drug

interaction between cyclophosphamide and voriconazole by inhibition of CYP2B6○ Yukihiro SHIBATA, Hiromi SATO, Akihiro HISAKA

Laboratory of Clinical Pharmacology and Pharmacometrics, Graduate School of Medical and Pharmaceutical Sciences, Chiba University

O-11※ InflammatoryboweldiseaseobservedintheAhr-nullmicewithananalysis of epigenome in genome-wide○ Seiichiroh OHSAKO1, Soto SUZUKI2, Kentaro YADA2, Satoshi UEHA3, Ming-Chen CHEN1, 3, Haru OGIWARA3, Kouji MATSUSHIMA3, Gaku ICHIHARA2

1Laboratory of Environmental Health Sciences, Graduate School of Medicine, The University of Tokyo, 2Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 3Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences, Tokyo University of Science

O-12 The therapeutic potential of Tpl2 inhibition on diabetic vasculopathy throughtheblockageoftheinflammasomecomplex○ Meei-Ling SHEU

Institute of Biomedical Sciences, College of Life Sciences, National Chung Hsing University, Taichung, Taiwan

Chairs: Takashi TOYAMA (Graduate School of Pharmaceutical Sciences, Tohoku University)

Tsuyoshi NAKANISHI ( Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University)

Mechanisms of toxicityO-13 RoleofTMX2onmaintainingnucleocytoplasmicgradientofRan

GTPase under oxidative stress conditions○ Ami OGURO1, Yasuhiro ISHIHARA1, Takeshi YAMAZAKI1, Susumu IMAOKA2

1Graduate School of Integrated Sciences for Life, Hiroshima University, 2Department of Biomedical Chemistry, School of Science and Technology Kwansei Gakuin University

O-14 EffectsofchlorogenicacidonglucosemetabolismviaHIF-1alphaandNrf2○ Akihito MIYATA, Rika SAKUMA, Susumu IMAOKA

Department of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University

O-15※ Reversetoxicologyforidentifyingnovel,safe,andeffectivevaccineadjuvants○ Takuo MIZUKAMI1, Haruka MOMOSE1, Eita SASAKI1, Keiko FURUHATA1, Hideki KUSUNOKI1, Hideki ASANUMA2, Isao HAMAGUCHI1

1Department of Safety Research on Blood and Biologicals, National Institute of Infectious Diseases, 2Influenza Research Center, National Institute of Infectious Diseases

Program

(J

uly 1, A

M)

Oral Session 4 July 1 (Wed) 10:40 - 12:04Track 7

Chairs: Takao ASHIKAGA (National Institute of Health Sciences Division of Risk Assessment)

Toshiko TANAKA-KAGAWA (Yokohama University of Pharmacy)

Analytical methodO-16 Elemental analysis of single cell using ICP mass spectrometry

○ Yu-ki TANAKA1, Risako IIDA1, Tetsuo KUBOTA2, Michiko YAMANAKA2, Naoki SUGIYAMA2, Yasumitsu OGRA1

1Graduate School of Pharmaceutical Sciences, Chiba University , 2Agilent Technologies

Alternatives to mammalian modelsO-17 High-throughput cardiotoxicity screening system for Onco-Cardiology

Kayoko YAMADA1, 2, Riho MASUKAWA1, 2, Itsuko KURODA1, 2, Yuka MIZUTANI1, 2, Takako FURUICHI1, 2, ○ Toshio TANAKA1, 2

1Department of Systems Pharmacology, Mie University Graduate School of Medicine, 2Mie University Medical Zebrafish Research Center

O-18 Development of AI-based prediction system for mutagenicity○ Mika YAMAMOTO1, Takeshi SATO1, Naoko OTANI1, Hideyoshi FUJI2

1Drug Safety Research Lab., Astellas Pharma Inc., 2Advanced Informatics and Analytics, Astellas Pharma Inc.

Chairs: Kohei MATSUSHITA (Division of Pathology, National Institute of Health Sciences)

Kouichi YOSHINARI (Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka)

AOP (adverse outcome pathway)O-19 Development of Adverse Outcome Pathway (AOP) related to cancer

malignancy via Wnt/beta-catenin signaling in OECD○ Shihori TANABE1, Kazuhiko AOYAGI2, Sabina QUADER3, Horacio CABRAL4, Ryuichi ONO5, Akihiko HIROSE1, Hiroshi YOKOZAKI6, Hiroki SASAKI7

1Div. Risk Assessment, Biol. Safety Res. Center, Natl. Inst. Health Sci., 2Dept. Clin. Genomics, Natl. Cancer Center Res. Inst., 3iCONM, 4Grad. Sch. Engineer., Tokyo Univ., 5Div. Cel. Mol. Toxicol., Biol. Safety Res. Center, Natl. Inst. Health Sci., 6Grad. Sch. Med., Kobe Univ., 7Dept. Transl. Oncol., Natl. Cancer Center Res. Inst.

O-20 Study of structure-activity relationship of AhR ligand using toxicological information○ Hideko SONE, Masahiro MIKI

Yokohama University of Pharmacy

EpidemiologyO-21 Healtheffectsof1-bromopropaneonmaleworkers

○ Masaru MIZUKI1, 2, Ryuta ABE3, Hirokazu TOUBOU1, Kouhei HASEGAWA1, 4, Teruomi TSUKAHARA1, 2, Tetsuo NOMIYAMA1, 2

1Department of Preventive Medicine and Public Health, Shinshu University School of Medicine., 2Department of Occupational Medicine, Shinshu University School of Medicine., 3Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine., 4Shinshu University Center for Health Safety and Environmental Management

Risk assessmentO-22 Environmental risk assessment: The ongoing update of CTD module 1.6

guideline in the European Union○ R. Arno WESS1, Stefan HöGER1, Toshihide HAYASHI2

1Innovative Environmental Services (IES) Ltd, 2Ina Research Inc.

Pro

gram

(J

uly

1, A

M)

Day 3 PM (July 1 (Wed))

Track 1


Challenge to digitize non-clinical study data to construct new toxicological study evaluation technologyChairs: Mutsumi SUZUKI (Non-clinical Evaluation Committee, The Japan Pharmaceutical Manufactures Association (JPMA))

Osamu FUEKI (Pharmaceuticals and Medical Devices Agency)

S27-1 Overview/Current issues surrounding SEND○ Mutsumi SUZUKI

Non-clinical Evaluation Committee, The Japan Pharmaceutical Manufactures Association (JPMA)

S27-2 The current status of SEND in the US and the challenges in SEND implementation○ Audrey A WALKER

Charles River Laboratories, Canada

S27-3 Proposed usage of SEND for PMDA in toxicity data review to ensure human safety of IND and NDA○ Satoshi TSUNODA


S27-4 Standardizationonnonclinicaldata~Pointstoconsiderforeffectivedata accumulation for data utilization~○ Gen SATO

SEND Task Force, Non-Clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceutical Manufacturers Association (JPMA)

S27-5 Using SEND datasets to enable large-scale data analytic approaches for preclinical toxicology data○ Tamio FUKUSHIMA

Drug Safety Evaluation, Shionogi Co & Ltd.

Discussion


Program

(J

uly 1, P

M)

Track 2


Highway to Clinical Prediction through Microphysiological Systems: the Junction of Toxicology, DMPK and BiotechnologyChairs: Seiichi ISHIDA (National Institute of Health Sciences)

Tetsuro ARAKI (Asahi Kasei Pharma Corporation)

S28-1※ Organ toxicity evaluation using Microphysiological Systems (MPS)○ Seiichi ISHIDA


S28-2 Fabrication of tissue models by cell accumulation and sedimentary culture technologies○ Michiya MATSUSAKI1, Kaoru SATO2

1Graduate School of Engineering, Osaka University, 2National Institute of Healthcare Sciences

S28-3 Kidney microphysiological system (MPS) for nephrotoxicity assays○ Hiroshi KIMURA

Tokai University

S28-4 Gut-liver interaction in drug metabolism observed in microphysiological system○ Hiroshi ARAKAWA, Takumi KAWANISHI, Yukio KATO

Department of Molecular Pharmacotherapeutics, Faculty of Pharmacy, Kanazawa University

S28-5 OverviewofAMED-MPSproject;User-drivenMicrophysiologicalSystem(MPS) development○ Hitoshi NARAOKA

Stem Cell Evaluation Technology Research Association

Track 3


Toxico-epigenomics learned from a viewpoint of developmental biology and congenital anomalyChairs: Kinichi NAKASHIMA (Graduate School of Medical Sciences, Kyushu Univeristy)

Satoshi KITAJIMA ( Division of Cellular & Molecular Toxicology, Center for Biological Safety & Research, National Institute of Health Sciences )

S29-1 FatespecificationofneuralstemcellsregulatedbyMeCP2throughmiRNA processing○ Kinichi NAKASHIMA

Graduate School of Medical Sciences, Kyushu University

Pro

gram

(J

uly

1, P

M)

S29-2 Epigenetic changes in the genome during early vertebrate development○ Hiroyuki TAKEDA

Department of Biological Sciences, Graduate School of Science, University of Tokyo

S29-3 Epigenomechangesintheoffspringaffectedbythefetalandneonatalenvironment and their remnants○ Kenichiro HATA

Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development

S29-4 Drug development and safety evaluation of epigenetic drugs○ Kenji TAKI, Ikuo HORII

Drug Safety R&D, Pfizer R&D Japan

S29-5 EV-associated miRNAs and liquid biopsy○ Ryuichi ONO

Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research (CBSR), National Institute of Health Sciences (NIHS)

Discussion

Track 4


New Tides of Redox Toxicology: A Discussion of the Present and Future with Young ResearchersChairs: Keiko TAGUCHI (Department of Medical Biochemistry, Graduate School of Medicine, Tohoku University)

Yasuhiro SHINKAI (Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba)

Introduction ○ Yasuhiro SHINKAI


S30-1 ALIS (aggresome-like induced structures) as an oxidative stress barometer○ Takuya NOGUCHI, Atsushi MATSUZAWA


S30-2 Redoxadductome:acomprehensiveanalysisofproteinmodificationsby electrophiles○ Takahiro SHIBATA1, 2

1Graduate School of Bioagricultural Sciences, Nagoya University, 2Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University

S30-3※ Keap1-Nrf2 system and liver toxicology ○ Keiko TAGUCHI, Masayuki YAMAMOTO

Department of Medical Biochemistry, Graduate School of Medicine, Tohoku University

S30-4 Redox regulation by sulfane sulfur and phase zero reaction of environmental electrophiles○ Yasuhiro SHINKAI, Yoshito KUMAGAI


Program

(J

uly 1, P

M)

S30-5 Protective role of reactive sulfur species under electrophilic stress○ Takamitsu UNOKI1, Masahiro AKIYAMA2, Yasuhiro SHINKAI2, Yoshito KUMAGAI2, Masatake FUJIMURA1

1Department of Basic Medical Sciences, National Institute for Minamata Disease, 2Faculty of Medicine, University of Tsukuba

Conclusion ○ Keiko TAGUCHI

Department of Medical Biochemistry, Graduate School of Medicine, Tohoku University

Track 5


Active career of toxicologists : Expectations of what outsiders see through toxicologistsChairs: Yukinori AMANO (JSOT Science and Publicity Commitee, Kowa Company. Ltd.)

Jihei NISHIMURA (Pharmaceuticals and Medical Devices Agency)

W7-1 Introduction○ Yukinori AMANO1, 2

1JSOT Science and Publicity Commitee, 2Kowa Company. Ltd.

W7-2 Toxicologists x Real World Evidence = ?? (from the perspective of pharmacovigilance)○ Motonobu SAKAGUCHI

Global Patient Safety Evaluation Japan, Takeda Development Center Japan, Takeda Pharmaceutical Company

W7-3 Expectation from an investigator of early clinical trials○ Yuji KUMAGAI

Kitasato Clinical Research Center

W7-4 Message from a hospital pharmacist○ Hirotaka KANZAKI1, Kazuhiko YAMAJI1, Takao KIMURA3, Yasutomo HASHIZUME3, Eriko TSUTSUMI3, Makoto YAMAMOTO3, Kyoko OGAWA3, Seitaro TAHARA3, Tetsuya TAKISHITA3, Shigeki NISHIHARA2, Toshiaki SENDO2

1Division of Medical Innovation and Sciences, Department of Pharmacy, Okayama University Hospital, 2Department of Pharmacy, Okayama University Hospital, 3KIMURA Information Technology Co., Ltd

W7-5 How can patients contribute to rare disease research and orphan drug development? -Current status of rare disease patients in Japan ○ Yukiko NISHIMURA, Kunihiro NISHIMURA, Shun EMOTO

NPO ASrid

Pro

gram

(J

uly

1, P

M)

Track 6


Advances of in vivo mutagenesis studies: detection and risk evaluationChairs: Yasunobu AOKI ( Center for Health and Environmental Risk Research Center, National Institute for Environmental

Studies)

Kenichi MASUMURA (Division of Genetics and Mutagenesis, National Institute of Health Sciences)

S31-1 Contribution of reporter gene transgenic rodents to toxicology ○ Takashi UMEMURA1, 2

1Faculty of Animal Health Technology, Yamazaki University of Animal Health Technology, 2Division of Pathology, National Institute of Health Sciences

S31-2 Mutagenicity in germ cells and detection of de novo mutations in the offspring○ Kenichi MASUMURA

Division of Genetics and Mutagenesis, National Institute of Health Sciences

S31-3 Current status and future prospects of non-biased mutation analyses by using next generation sequencing technology○ Yukari TOTSUKA

National Cancer Center Research Institute

S31-4 Environmental monitoring by using living organisms: Detection of mutagenesis induced by exposure of environmental chemical mixture by using transgenic rodent in vivo assay○ Yasunobu AOKI

Center for Health and Environmental Risk Research Center, National Institute for Environmental Studies

S31-5※ Evaluation of genome instability and safety of cell therapy products○ Yoji SATO

Division of Cell-Based Therapeutic Products, National Institute of Health Sciences

Program

(J

uly 1, P

M)

Track 7


Theapplicationandintegrationofnovelsafetystrategiestoinfluencebetter decision-making in early drug discoveryChairs: Satoko KAKIUCHI-KIYOTA (Safety Assessment, Genentech, USA)

Russell NAVEN (Preclinical Safety Assessment, Vertex Pharmaceuticals, USA)

Introduction W8-1 Utility of genetically engineered rodent models during drug discovery:

case studies to support target safety assessment and mechanistic investigation○ Satoko KAKIUCHI-KIYOTA

Safety Assessment, Genentech, USA

W8-2※ Safety by design: Lessons learned from applying safety screening strategies during the design stage of small molecule drug discovery○ Russell NAVEN

Preclinical Safety Assessment, Vertex Pharmaceuticals, USA

W8-3※ An investigative approach to address systemic toxicity issues and mechanisms in early safety assessment○ Jumpei KIYOKAWA

Research Division, Chugai Pharmaceutical Co., Ltd.

W8-4 Harnessingthepotentialofartificialintelligenceinsafetyassessment○ Alex N CAYLEY

Lhasa Limited, Leeds, UK

Q&A and Panel Discussion

Pro

gram

(J

uly

1, P

M)

Day 1~3 (June29 (Mon) ~ July1 (Wed)) e-Poster(Poster Session)

Pharmaceutical drugs (chemicals)P-1E Novelmechanismsbywhichthemoleculartargetdruggefitinib

suppresses cancer cell invasion ○ Yuto SEKIGUCHI, Yusuke HIRATA, Takuya NOGUCHI, Atsushi MATSUZAWA


Regenerative medicine and cell therapyP-2E Development of safety assessment system using primate model for

practicaluseofgeneticallymodifiedTcells○ Hidemi MOCHIZUKI1, 2, Kengo SAKAMOTO1, Hirokazu MOROKAWA2, 3, Miyuki TANAKA2, 3, Shoji SAITO2, 3, Shigeki YAGYU2, 4, Yozo NAKAZAWA2, 3, Akihito SHIMOI1, 2

1Ina Research Inc., 2Center for Advanced Research of Gene & Cell Therapy, Shinshu University, 3Department of Pediatrics, Shinshu University School of Medicine, 4Department of Pediatrics, Kyoto Prefectural University of Medicine

Agricultural chemicalsP-3S Biomonitoring of a propetamphos metabolite in human urine using gas

chromatography-mass spectrometry○ Nayan Chandra MOHANTO1, Hirotaka SATO1, Yuki ITO1, Jun UEYAMA2, Kyoko MINATO1, Naoko OYA1, 3, Mio MIYAKE1, Karin NOMASA1, Masahiro GOTOH1, Isao SAITO4, Eiji SHIBATA5, Michihiro KAMIJIMA1

1Dept. of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences, Japan, 2Dept. of Pathological Laboratory Sciences, Nagoya University Graduate School of Medicine, Japan, 3Research Fellow of Japan Society for the Promotion of Science, Japan, 4Food Safety and Quality Research Center, Tokai COOP Federation, Japan, 5Dept. of Health and Psychosocial Medicine, Aichi Medical University School of Medicine, Japan

P-4S Signal toxicity caused by nicotinic acetylcholine receptor agonist and development of detection method using two-photon microscope○ Anri HIRAI1, Shouta SUGIO2, Yoshinori IKENAKA1, Nimako COLLINS1, Shouta M.M NAKAYAMA1, Nobuhiko HOSHI3, Hiroaki WAKE2, 4, Mayumi ISHIZUKA1

1Laboratory of Toxicology, School/Faculty of Veterinary Medicine, Hokkaido University, 2Division of System Neuroscience, Graduate School of Medicine, Kobe University, 3Animal Molecular Morphology & Histophysiology, Division of Animal Science, Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University, 4Anatomy and Cell Biology, Graduate School of Medicine, Nagoya University

P-5S Chronic glyphosate exposure elicits neuronal cell death and microglia activation in developing rat cerebellum○ Ken FUTAGAMI1, Thomas Kwong Soon TIONG1, Christine Li Mei LEE1, Yong Lin HUANG2, Yoko NOMURA2, Yasunari KANDA3, Sachiko YOSHIDA1

1Toyohashi University of Technology, 2Queens College, the City University of New York, USA, 3National Institute of Health Sciences


Program

(e-P

oster)

P-6S Potentiation of developmental malformation and neurotoxicity of neonicotinoid insecticide, Acetamiprid○ Christine Li Mei LEE1, Rie MATSUFUSA1, Thomas Kwong Soon TIONG1, Johnny Ademir LOPEZ2, Yoko NOMURA2, Yasunari KANDA3, Sachiko YOSHIDA1

1Toyohashi University of Technology, 2Queens College, the City University of New York, USA, 3National Institute of Health Sciences

MetalsP-7S※ Mechanisms of cisplatin-induced chronotoxicity in mice

○ Sarah TOMINAGA1, Hiroki YOSHIOKA1, 2, Mayuko SAKANASHI1, Tohru MAEDA1, Masae YOSHIKAWA1, Sang Jun PARK3, Nobuhiko MIURA4

1Department of Pharmacy, College of Pharmacy, Kinjo Gakuin University, 2The University of Texas Health Science at Houston, USA, 3College of Living Environment, Kinjo Gakuin University, 4Department of Pharmacy, College of Pharmacy, Yokohama University of Pharmacy

P-8E Mechanism involved in the induction of OSM expression by methylmercury in microglia○ Takayuki HOSHI1, 2, Takashi TOYAMA1, Akira NAGANUMA1, Yoshiro SAITO1, Gi-Wook HWANG1, 2

1Graduate School of Pharmaceutical Sciences, Tohoku University, 2Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University

P-9S Contributionofendoplasmicreticulumstresstosite-specificneuropathy by methylmercury ○ Hideki HIRAOKA1, Takao IWAWAKI2, Yoshito KUMAGAI3, Masatake FUJIMURA4, Takashi UEHARA1

1Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Science, Okayama University, 2Division of Cell Medicine, Department of Life Science, Medical Research Institute, Kanazawa Medical University, 3Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba, 4Toxicologic Pathology Section, Department of Basic Medical Science, National Institute for Minamata Disease

P-10S Impairments of multisensory modality due to methylmercury exposure - behavioral analysis of rat○ Yuta YAMADA1, Yo SHINODA1, Eiko YOSHIDA2, Toshiyuki KAJI2, Yasuyuki FUJIWARA1

1Department of Environmental Hearth, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 2Department of Environmental Hearth, Faculty of Pharmaceutical Sciences, Tokyo University of Science

P-11S Effectofsodiumarseniteonthebloodcoagulation-fibrinolyticsystemin cultured vascular endothelial cells and macrophage-like THP-1 cells○ Tsuyoshi NAKANO1, Yumi ARAKI1, Tsutomu TAKAHASHI1, Chika YAMAMOTO2, Toshiyuki KAJI3, Yasuyuki FUJIWARA1

1Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 2Department of Environmental Health, Faculty of Pharmaceutical Sciences, Toho University, 3Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science

P-12S Prolonged exposure to diphenylarsinic acid induced aberrant activation of cultured normal human cerebellar astrocytes: Phosphorylation of MAP kinases, upregulation of transcription factors and oxidative stress response factors, and secretion of glutathione○ Shoto SASAKI1, Takamasa TSUZUKI2, Kazunori YUKAWA2, Takayuki NEGISHI2

1Department of Physiology, Graduate School of Pharmacy, Meijo University, 2Department of Physiology, Faculty of Pharmacy, Meijo University

Pro

gram

(e

-Pos

ter)

P-13S Transporters LAT-1 and MRP-2 as a key factor of methylmercury cytotoxicityspecificinratdorsalrootganglioncellsinculture○ Kazuhiro AOKI1, Eiko YOSHIDA1, Yo SHINODA2, Yasuyuki FUJIWARA2, Toshiyuki KAJI1

1Department of Environmental Health, Faculty of Pharmaceutical Science, Tokyo University of Science, 2Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

P-14S TheroleofTNF-αinmethylmercury-inducedneurotoxicity○ Fumika KATAMI1, Eiko YOSHIDA1, Yo SHINODA2, Yasuyuki FUJIWARA2, Toshiyuki KAJI1

1Department of Environmental Health, Faculty of Pharmaceutical Science, Tokyo University of Science, 2Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy & Life Science

P-15S Cadmium-induced ABCB1 transporter expression in renal proximal tubular cells○ Chikage MORI, Jin-Yong LEE, Maki TOKUMOTO, Masahiko SATOH

Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University

P-16E※ Enhanced cytotoxicity and altered biglycan synthesis in vascular endothelial cells by cadmium through induction of CHSY1 expression○ Takato HARA1, Shogo MATSUURA1, Keita AIKAWA1, Shuta ONIZAWA1, Mai YOSHIDA1, Toshiyuki KAJI2, Chika YAMAMOTO1


Foods, food additives, and food contaminantsP-17S trans-Fatty acids promote DNA damage-induced apoptosis via the

mitochondrial JNK-Sab-ROS axis○ Aya INOUE, Yusuke HIRATA, Takuya NOGUCHI, Atsushi MATSUZAWA


P-18E TheeffectsofCYPinhibitorsandinducersonpharmacokineticsandtoxicity of substance responsible for “Gin-nan food poisoning” (4′-O-Methylpyridoxine : MPN)○ Mika ISHIKAWA, Eri OKIMOTO, Maaya SASAKI, Ryota KONNO, Eri NAKATA, Daisuke KOBAYASHI, Teruki YOSHIMURA, Keiji WADA

School of Pharmaceutical Sciences, Health Sciences University of Hokkaido

P-19E Possible involvement of chromosome aberrations and DNA damages in acetamide-induced hepatocarcinogenesis in rats○ Kenji NAKAMURA1, 2, Yuji ISHII1, Aki KIJIMA1, Shinji TAKASU1, Takehiko NOHMI1, 2, Makoto SHIBUTANI2, Kumiko OGAWA1


Environmental pollutantsP-20S TetrabromobisphenolA(TBBPA),abrominatedflameretardant,causes

depression-like behavior in mice○ Ryohei A. FUKUZAWA, Akira A. NAKAJIMA

Faculty of Agriculture and Life Science, Hirosaki University

Program

(e-P

oster)

P-21S※ The role of decreased prolactin by dioxin in nursing behavior and maternallactationsuppressioninfemaleoffspring○ Ming YUAN1, Tomoki TAKEDA1, 3, Takeshi MATSUSHITA2, Waka IZUMOTO1, Misaki FUJII1, Yoshitaka TANAKA1, Yuji ISHII1

1Graduate School of Pharmaceutical Sciences, Kyushu University, 2Faculty of Pharmaceutical Sciences, Kyusyu University, 3Japan Bioassay Research Center

NanomaterialsP-22E Silver nanoparticles upregulate amyloid precursor protein in

SH-SY5Y cells○ Kazuma HIGASHISAKA1, 2, Junpei KASAHARA2, Miyuki SAKURAI2, Asato TOYODA2, Shun-ichi ETO2, Hirofumi TSUJINO2, Kazuya NAGANO2, Yasuo TSUTSUMI2, 3

1Graduate School of Medicine, Osaka University, 2Graduate School of Pharmaceutical Sciences, Osaka University, 3Global Center for Medical Engineering and Informatics, Osaka Univ.

P-23S Hazardidentificationandexploringofcrossreactivitytriggeredbyamorphous silica nanoparticles via acquired immunity○ Shun-ichi ETO1, 2, 3, Kazuma HIGASHISAKA1, 4, Kenta SATO1, Aoi KOSHIDA1, Mao OGURA1, Hirofumi TSUJINO1, Kazuya NAGANO1, 2, 5, Yasuo TSUTSUMI1, 6

1Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 2JSPS Research Fellowship for Young Scientist (DC1), 3Interdisciplinary Program for Biomedical Science, Osaka University, 4Department of Legal Medicine, Graduate School of Medicine, Osaka University, 5Department of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 6Global Center for Medical Engineering and Informatics, Osaka University

P-24S Theeffectofsilvernanoparticlesonforskolin-inducedBeWosyncytialization○ Yuji SAKAHASHI1, Kazuma HIGASHISAKA1, 2, Ryo ISAKA1, Nanan ISHIDA1, Kotoe KIYOMOTO1, Shintaro YAMAGUCHI1, Go KITAHARA1, Hirofumi TSUJINO1, Kazuya NAGANO1, 3, Yasuo TSUTSUMI1, 4

1Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 2Department of Legal Medicine, Graduate School of Medicine, Osaka University, 3Department of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 4Global Center for Medical Engineering and Informatics, Osaka University

P-25S Cellular response of human lymphatic endothelial cells to carbon nanomaterials○ Makoto IZUMIYA1, 2, Mahoko SANO1, 2, Katsuya UEDA1, 3, Kosuke KONISHI1, 2, Haruka ISHIDA1, 3, Kaoru AOKI4, Naoto SAITO1, Hisao HANIU1, 2, 3

1Biomedical Research Institute, 2Graduate School of Science and Engineering, Shinshu University, 3Graduate School of Medical Science and Engineering, Shinshu University, 4Department of Health, Medical School, Shinshu University

Nervous systemP-26S AMPA receptor activation in the substantia nigra aggravates Parkinson’s

syndrome in aged rats via nigral intracellular Zn2+ dysregulation○ Misa KATAHIRA, Nana SAEKI, Ryusuke NISHIO, Azusa TAKEUCHI, Hiroki MORIOKA, Haruna TAMANO, Atsushi TAKEDA

Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka

Pro

gram

(e

-Pos

ter)

P-27S Ninjin-yoei-to, a Kampo medicine, prevents hippocampal neurodegenerationbyamyloidβ1-42-induced Zn2+ toxicity○ Haruna TOKORO, Ryo FURUHATA, Aoi SHIOYA, Daichi MURAKAMI, Haruna TAMANO, Atsushi TAKEDA

Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka

P-28E※ DeletionofNrf2enhancessusceptibilitytoneurotoxiceffectsofacrylamide in mice○ Frederick Adams EKUBAN1, Cai ZONG1, Madoka TAKIKAWA1, Kouta MORIKAWA1, Toshihiro SAKURAI1, Sahoko ICHIHARA2, Ken ITOH3, Masayuki YAMAMOTO4, Seiichiroh OHSAKO5, Gaku ICHIHARA1

1Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2Jichi Medical University, 3Hirosaki University, 4Tohoku University, 5The University of Tokyo

P-29E※ Neurite retraction in bioaminergic neurons induced by exposure to conditioned medium from acrylamide-treated microglial cells○ Harue SATO1, Cai ZONG1, Sho IWAMA1, Benoit SCHNEIDER2, Makoto URUSHITANI3, Gaku ICHIHARA1

1Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2University of Paris, Inserm UMR-S1124, Paris, France, 3Department of Neurology, Shiga University of Medical Science

P-30S Effectsofairborneparticleexposureontheprognosisofexperimentalischemic stroke○ Miki TANAKA1, Kouichi ITOH2, Yasuhiro ISHIHARA1, Yu NABETANI3

1Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, 2Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 3Department of Applied Chemistry, Miyazaki University

P-31S※ Propagation measurement between brain regions in acute brain slice using CMOS-MEA○ Shuhei NOJI1, Yuri KATO2, Aoi ODAWARA1, Naoki MATSUDA1, Tadayuki TAURA2, Yusuke OIKE2, Ikuro SUZUKI1

1Department of Electronics, Tohoku Institute of Technology, 2Sony Semiconductor Solutions Corporation

P-32S※ Comparison of the dose-dependent changes in cultured neural network activities to convulsants administration with drug concentration in rat CSF during seizures○ Remi YOKOI1, 2, Yuto ISHIBASI1, Naoki MATSUDA1, Kenichi KINOSHITA3, Ai OKAMURA3, Takafumi SHIRAKAWA3, Ikuro SUZUKI1

1Tohoku Institute of Technology, 2Japan Society for the Promotion Science, 3 Drug Safety Research Lab., Astellas Pharma Inc.

P-33S Seizure risk assessment using an in vitro MEA system for compounds whose seizure risk is not suggested based on their pharmacological action○ Yuto ISHIBASHI1, Ai OKAMURA2, Remi YOKOI1, Kenichi KINOSHITA2, Takafumi SHIRAKAWA2, Ikuro SUZUKI1

1Graduate School of Engineering, Tohoku Institute of Technology, 2Drug Safety Research Lab., Drug Discovery Research, Astellas Inc.

P-35S※ Detection of the astrocyte oscillation and oscillation-based drug responses using MEA○ Naoki MATSUDA, Yuto ISHIBASHI, Aoi ODAWARA, Ikuro SUZUKI

Tohoku Institute of Technology, Graduate School of Engineering

Program

(e-P

oster)

LiverP-36E Exploring for new biomarkers using liver organoids derived from

nonalcoholic steatohepatitis (NASH) model mice ○ Megumi YAMANAKA1, Elbadawy MOHAMED1, Kimika HAYASHI1, Yuta GOTO1, Ryouichi TSUNEDOMI2, Shoichi HAZAMA2, 3, Hiroaki NAGANO2, Toshinori YOSHIDA4, Makoto SHIBUTANI4, Ryo ICHIKAWA4, Junta NAKAHARA4, Tsutomu OMATSU5, Tetsuya MIZUTANI5, Yukie KATAYAMA5, Yuta SHINOHARA6, Masahiro KANEDA7, Hideyuki YAMAWAKI8, Tatsuya USUI1, Kazuaki SASAKI1

1Lab. Vet Pharm., Dept Vet Med., Tokyo Agri&Tech Univ., 2Dept. Gastro-Breast & Endocrine Surgery, Grad. Sch. Med, Yamaguchi Univ., 3Dept.Translational Res. & Develop. Therap. against Cancer., Sch. Med, Yamaguchi Univ., 4Lab. Vet Pathol., Dept Vet. Med., Tokyo Agri&Tech Univ., 5Res & Edu Ctr., Dept Vet Med., Tokyo Agri&Tech Univ., 6Pet Health & Food Division, Iuskura Industry, 7Lab. Vet Anatomy., Dept Vet Med., Tokyo Agri&Tech Univ., 8Lab. Vet Pharm., Dept Vet Med., Kitasato Univ.

P-37E Characterization of transgenic mice expressing human NPC1L1, an exacerbation factor of steatosis, in hepatocytes as an NAFLD model animal○ Yu TOYODA1, Tappei TAKADA1, Masakazu UMEZAWA2, Yoshihide YAMANASHI1, Ken TAKEDA3, Hiroshi SUZUKI1

1Department of Pharmacy, The University of Tokyo Hospital, 2Department of Materials Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 3Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University

P-38S HepatocarcinogenesiswithNASHinmicefedacholine-deficient,methionine-lowered,aminoacid-defined,highfatdiet(CDAA-HF-T(-))○ Akari ABE1, Noriko KEMURIYAMA2, Kinuko UNO3, Ayana SHIMAI2, Fumika HAGA2, Ayane YAMAGUCHI1, Megumi YUKI4, Syuji OGAWA3, Ryuhei SANO3, Atsushi WATANABE3, Katsuhiro MIYAJIMA1, 2, 3, Dai NAKAE1, 2, 3

1Dept. Nutr. Sci. Food Safety, Grad. Sch. Agricul., Tokyo Univ. Agricul., 2Dept. Nutr. Sci. Food Safety, Facul. Appl. Biosci., Tokyo Univ. Agricul., 3Dept. Food Nutr. Sci., Grad. Sch. Agricul., Tokyo Univ. Agricul., 4New Histo Science Laboratory Co., Ltd.

P-39S Analysis of chemical and structural features and use of ATC classificationinpredictiveevaluationofdrug-inducedliverinjury○ Yuki SHIMIZU1, Eri YONEKAWA1, Hirokazu YAMAZAKI1, Takamitsu SASAKI1, Michiko WATANABE1, Ryota SHIZU1, Takuomi HOSAKA1, Jun-ichi TAKESHITA2, Kouichi YOSHINARI1

1Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 2Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology

P-40S Diclofenac exacerbates lipid accumulation in liver by impairing mitochondrial function○ Tomoyuki SATO, Akinori TAKEMURA, Kousei ITO

Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University

P-41S※ The involvement of ryanodine receptors in halothane-induced liver injury in mice○ Ru JIA, Shingo ODA, Tsuyoshi YOKOI

Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, Nagoya, Japan

Pro

gram

(e

-Pos

ter)

P-42E AnovelmechanismofhypoglycemiceffectofadopamineD2receptoragonist Bromocriptine○ Takaya KUTSUKAKE1, Tomoyuki KISHIDA1, Ryohei YOKOI1, Shinji SOUMA2

1Toxicology, Safety Research Lab. Kissei Pharmaceutical Co., Ltd , 2Safety Research Lab. Kissei Pharmaceutical Co., Ltd

P-43E TheinfluenceofPXRactivationonlivercarcinogenesisinmice○ Ryota SHIZU1, Mai ISHIMURA1, Sumihito NOBUSAWA2, Takuomi HOSAKA1, Takamitsu SASAKI1, Satoru KAKIZAKI2, Kouichi YOSHINARI1

1Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 2Gunma University Graduate School of Medicine

KidneyP-44S AnalysisofthemechanismofproximaltubuleS3region-specific

cytotoxicity to cisplatin○ Hiroki TAGUCHI, Hiroki NAKASONE, Hitomi FUJISHIRO, Daigo SUMI, Seiichiro HIMENO

Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University

P-45S Effectofhighfatdietonkidneyindb/dbandKK-Aymice○ Ayane YAMAGUCHI1, Katsuhiro MIYAJIMA1, 2, 3, Kinuko UNO2, Miki SUGIMOTO5, Fuko KUROKI5, Mei NISHIDA5, Tomoki OGOU5, Noriko KEMURIYAMA3, Masami SHINOHARA4, Dai NAKAE1, 2, 3, Takeshi OHTA5

1Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture, 2Department of Food and Nutrition Science, Graduate School of Agriculture, Tokyo University of Agriculture, 3Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Tokyo University of Agriculture, 4Tokyo Animal & Diet Dept. CLEA Japan, Inc., 5Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University

SkinP-46S Molecular mechanisms of sebaceous gland dysfunctions by

vemurafenib,aBRAFinhibitor,indifferentiatedhamstersebocytesinvitro○ Toshikazu KOIWAI, Hiroaki SAKAUE, Takashi SATO

Department of Biochemistry Tokyo University of Pharmacy and Life Sciences

P-47S Effectsofpersonalcareproductsonatopicdermatitis○ Saori TAN1, Akiko HONDA1, 2, Natsuko MIYASAKA2, Michitaka TANAKA2, Shin TAMURA1, Hitoshi OKANO1, Zaoshi WANG1, Megumi NAGAO2, Kayo UEDA1, 2, Hirohisa TAKANO1, 2

1Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, 2Kyoto University Graduate School of Global Environmental Studies

Sensory organP-48E Results and challenges in subretinal injection in rats, rabbits,

and cynomolgus monkeys○ Megumi SAKATA, Koji KABAYAMA, Tomoaki ARAKI, Hideshi TSUSAKI


Program

(e-P

oster)

Cardio vascular systemP-49E Cardiovascular evaluation in rabbits: a preliminary study toward

application to safety evaluation of ophthalmic drugs○ Miki MASATSUGU, Ikuyo ATSUMI, Yoshinori YAMAGIWA, Masaaki KURATA

Central Research Laboratories, Research & Development Division, Senju Pharmaceutical Co., Ltd.

P-50E※ Improvement of human iPSC-derived cardiomyocyte treated with subchronic electrical stimulation for evaluating the cardiotox risk○ Kaoru MORIMURA1, 3, Ayako KAMEI1, 3, Maiko OMORI1, Katsuyuki KAZUSA2, 3, Aya UEKI4

1FUJIFILM Corporation Bio Science & Engineering Laboratory, 2Astellas Pharma Inc. Drug Safety Research Laboratories, 3Consortium for Safety Assessment using Human iPS cells (CSAHi) Heart team, 4PERSOL TEMPSTAFF CO., LTD. Research and Development Tsukuba Office

Reproductive and developmental toxicologyP-51S Influencesofdiazepamexposureduringpregnancyonneural

development○ Misaki KUWAHARA, Satoshi KITAOKA, Yuya KOYAMA, Reo KAINUMA, Keita NEGISHI, Wataru OCHIAI


P-52S Analysis of expression and localization of drug metabolizing enzyme cytochrome P450 2C during mouse liver development○ Yuya KOYAMA, Satoshi KITAOKA, Misaki KUWAHARA, Misa TACHIBANA, Wataru OCHIAI


P-53E Effectofdevelopmentalexposuretoethanolonhippocampalneurogenesis in rats○ Yasunori TAKAHASHI1, 2, Risako YAMASHITA1, Satomi KIKUCHI1, 2, Hiromu OKANO1, 2, Kazumi TAKASHIMA1, 2, Mio KOBAYASHI1, Toshinori YOSHIDA1, 2, Makoto SHIBUTANI1, 2


P-54E Amelioratingeffectofα-glycosylisoquercitrinonbraininjurycausedbyLPS-induceddevelopmentalneuroinflammationinrats○ Hiromu OKANO1, 2, Yasunori TAKAHASHI1, 2, Kazumi TAKASHIMA1, 2, Satomi KIKUCHI1, 2, Risako YAMASHITA1, Mihoko KOYANAGI3, Shin-mo HAYASHI2, Toshinori YOSHIDA1, 2, Makoto SHIBUTANI1, 2

1LVP, TUAT, 2CDVS, TUAT, 3San-Ei Gen F.F.I., Inc.

P-55E※ Role of Death associated protein-like 1 (Dapl1) in steroidogenesis: study using Dapl1-null mice○ Hongbin CHEN1, Hiroe SANO1, Ren-shi LI2, Yukiko HATTORI1, Tomoki TAKEDA1, 3, Yoshitaka TANAKA1, Yuji ISHII1

1Graduate School of Pharmaceutical Sciences, Kyushu University , 2China Pharmaceutical University, 3Japan Bioassay Research Center

Pro

gram

(e

-Pos

ter)

Genetic toxicologyP-56E Investigation of in vivo comet assay in rabbit corneal epithelial cells

with single ophthalmic administration of genotoxic compounds○ Haruna TAHARA, Yoshinori YAMAGIWA, Miki MASATSUGU, Gen SUZUKI, Ikuyo ATSUMI, Yu HARANOSONO, Masaaki KURATA

Senju Pharmaceutical Co., Ltd. Research & Development Division

P-57E LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases○ Taiki ABE1, Ikumi UMEKI1, Shin-ichiro KANNO2, Shin-ichi INOUE1, Tetsuya NIIHORI1, Yoko AOKI1

1Department of Medical Genetics, Tohoku University School of Medicine, 2Division of Dynamic Proteome, Institute of Development, Aging, and Cancer, Tohoku University

CarcinogenicityP-58S Alkaline pH enhances DNA toxicity of 1,2-Dichloropropane

○ Yusuke KIMURA1, Cai ZONG1, Seiichiroh OSAKO2, Gaku ICHIHARA1

1Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2Laboratory of Environmental health Sciences, Faculty of Medicine, The University of Tokyo

Behavioral toxicologyP-59E Early-life exposure to low levels of permethrin exerts impairments in

learningandmemorywiththeeffectsonneuronalandglialpopulationin adult male mice○ Hirokatsu SAITO1, Kenshiro HARA2, Takashi TOMINAGA3, Kinichi NAKASHIMA4, Satoshi KITAJIMA1, Jun KANNO5, Kentaro TANEMURA2

1Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences, 2Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University, 3Laboratory for Neural Circuit Systems, Institute of Neuroscience, Tokushima Bunri University, 4Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, 5National Institute of Health Sciences

ImmunotoxicologyP-60E※ IdentificationofthedogorthologueofhumanMAS-relatedGprotein

coupledreceptorX2(MRGPRX2)essentialfordrug-induced pseudo-allergic reactions○ Eri HAMAMURA, Junya MATSUSHITA, Satoshi TAMAI, Takuma IGUCHI, Noriyo NIINO, Kazuyoshi KUMAGAI, Shinobu HAKAMATA, Yoshimi TSUCHIYA, Kazuhiko MORI


P-61E Involvement of immune tolerance systems in the onset of HLA allele-specificdrug-inducedimmunotoxicity○ Shigeki AOKI, Saki KUWAHARA, Takeshi SUSUKIDA, Kousei ITO


P-62S InvestigationofHLAallotype-specificskintoxicitybyabacavirusingHLA transgenic mice○ Yushiro YAMADA, Shigeki AOKI, Sota FUJIMORI, Kousei ITO


Program

(e-P

oster)

P-63S Influenceofexposuretoinorganicarseniccompoundsonallergicasthma development○ Yuri OGATA1, Naoki IWASITA1, 2, Keigo KURATA3, Yoshiichi TAKAGI4, Tomoki FUKUYAMA1

1 Azabu University Faculty of Veterinary Medicine, Pharmcology Laboratory, 2Bioalchemis, 3ITEA Inc. Institute of Tokyo Environmental Allergy, 4Japan SLC, Inc.

P-64S Characterization of thymic involution induced by organotin compounds○ Erina SHIRAISHI1, Kyohei TAKANO1, Daisuke MATSUMARU1, Akiko IDO1, Hisamitsu NAGASE1, 2, Tsuyoshi NAKANISHI1

1Faculty of Pharmacy, Gifu Pharmaceutical University, 2Gifu University of Medical Science

CytotoxicityP-65S Construction of a comprehensive mitochondrial toxicity assessment

system using galactose medium and loading mitochondrial ROS○ Yugo IKEYAMA, Tomoyuki SATO, Akinori TAKEMURA, Shuichi SEKINE, Kousei ITO

The Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University

Oxidative stressP-66S※ Induction of oxidative stress by iron exposure in Hep3B cells as a

β-Thalassemiamodel○ Amanda Putri ELVANDARI, Rika SAKUMA, Susumu IMAOKA


P-67S AnalysisofeffectsofchemicalsonDrosophila melanogaster○ Yuma NAGAI, Rintaro FUJIWARA, Katsunori FUJIO, Kyosuke YOSHIDA, Binh Duy TRAN, Kaeko KAMEI

Department of Functional Chemistry, Kyoto Institute of Technology

Mechanisms of toxicityP-68S Elucidation of the mechanisms of renal toxicity caused by antibacterial

cephems○ Tomohiro KAGI, Yuto SEKIGUCHI, Yusuke HIRATA, Takuya NOGUCHI, Atsushi MATSUZAWA


P-69E※ Characterization of human UDP-glucuronosyltransferase 1A7: the role of Trp208 and surrounding residues○ Ryota TSUTSUMI1, Yuu MIYAUCHI1, Natsuki EGOSHI1, Peter I. MACKENZIE2, Yoshitaka TANAKA1, Yuji ISHII1

1Graduate School of Pharmaceutical Sciences, Kyushu University, 2Clinical Pharmacology, College of Medicine and Public Health, Flinders University

P-70S Individual variations in expression of genes related to airway hyperresponsiveness in human trachea and lung○ Ayano KONDO1, Nozomi AKIYAMA1, Natsumi CHO1, Nobuhiko MIURA1, Ikuo KAWAMURA1, Yoko MORI2, Moeko NAGAI2, Takashi ISOBE1, Susumu OHKAWARA1, Nobumitsu HANIOKA1, Hideto JINNO2, Toshiko TANAKA-KAGAWA1

1Faculty of Pharmaceutical Sciences, Yokohama University of Pharmacy, 2Faculty of Pharmacy, Meijo University

Pro

gram

(e

-Pos

ter)

Cellular responseP-71S Oxysterol-activatednuclearreceptorLXR-alphaandLXR-betaregulate

each other’s expression in normal renal-derived cells and normal hepatocyte-derived cells○ Kouta SUGIZAKI, Sana FUJIKAWA, Saki OKAWA, Tomofumi FUJINO, Makio HAYAKAWA

Department of Hygiene and Health Sciences, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

P-72E Development of novel strategies for cancer therapy by using the inducer of the atypical cell death parthanatos○ Mayuka YAMADA, Yusuke HIRATA, Takuya NOGUCHI, Atsushi MATSUZAWA


P-73S Functional roles of TRAF2 in cisplatin-induced apoptosis○ Tatsuya SHIMADA, Mei TSUCHIDA, Takumi YOKOSAWA, Yusuke HIRATA, Takuya NOGUCHI, Atsushi MATSUZAWA


P-74S Intracellular signal pathway involved in the regulation of reactive sulfur species-producingenzymeexpressionbytransforminggrowthfactor-β1 in cultured vascular endothelial cells○ Musubu TAKAHASHI1, Tomoya FUJIE2, Akane TAKAHASHI1, Chika YAMAMOTO2, Toshiyuki KAJI1

1Department of Environmental Health, Faculty of Pharmaceutical Science, Tokyo University of Science, 2Department of Environmental Health, Faculty of Pharmaceutical Science, Toho University

Molecular toxicologyP-75S InterspeciesdifferenceinactivationofTRPA1byferulicacidanalogues

○ Yoko MORI1, Moeko NAGAI1, Susumu OHKAWARA2, Takashi ISOBE2, Akira AOKI1, Yoshinori OKAMOTO1, Nobumitsu HANIOKA2, Toshiko TANAKA-KAGAWA2, Hideto JINNO1

1Department of Pharmacy, Meijo University, 2Yokohama University of Pharmacy

Gene regulationP-76S Role of aryl-hydrocarbon receptor in malignant transformation of human

epidermal growth factor receptor 2-overexpressing breast cancer○ Nao SAITO1, Naoya YAMASHITA1, 2, Yuichiro KANNO1, Masakuni DEGAWA1, 3, Kiyomitsu NEMOTO1

1Fac. Pharm. Sci., Toho-Univ., 2Fac. Pharm. Sci., Doshisha Women's College of Liberal Arts, 3Sch. of Pharm. Sci., Univ. of Shizuoka

BiomarkersP-77E Prediction of drug-induced convulsion by using heart rate variability in

monkeys○ Kazuhiro KUGA1, Shoya NAGATA2, Chikao NAKAYAMA3, Harushige OZAKI1, Koichi FUJIWARA2

1Takeda Pharmaceutical Company Limited, 2Nagoya University, 3Kyoto University

Program

(e-P

oster)

P-78S※ Investigation of the Responsiveness to Liver Injury in hL-FABP Tg mice○ Kinuko UNO1, Katsuhiro MIYAJIMA1, 2, 3, Kanjiro RYU2, Keiichi OHATA4, Noriko KEMURIYAMA3, Dai NAKAE1, 2, 3

1Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture, 2Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture, 3Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, 4L-FABP Business Department, CMIC Holdings CO., Ltd.

P-79E Detection of drug-induced vasculitis using in vivo MRI○ Yuta FUJII1, Yuka YOSHINO1, Yasuaki UEMATSU1, Aya NAKAE2, Junichiro ENMI2, Yoshichika YOSHIOKA2, Izuru MIYAWAKI1


P-80E※ IdentificationofmicroRNAsassociatedwithcleftpalate○ Hiroki YOSHIOKA, Aimin LI, Zhonming ZHAO, Junichi IWATA

The University of Texas Health Science at Houston

Toxicity-testing methodsP-81E Establishment of 2.5D organoid culture model using 3D bladder cancer

organoid ○ Kimika HAYASHI1, Amira ABUGOMAA1, 2, Mohamed ELBADAWY1, 3, Megumi YAMANAKA1, Yuta GOTO1, Takashi MORI4, 5, Tsuyoshi UCHIDE6, Daigo AZAKAMI7, Ryuji FUKUSHIMA8, Toshinori YOSHIDA9, Makoto SHIBUTANI9, Risako YAMASHITA9, Hideyuki YAMAWAKI10, Yuta SHINOHARA1, 11, Masahiro KANEDA12, Tatsuya USUI1, Kazuaki SASAKI1

1Laboratory of Veterinary Pharmacology, Department of Veterinary, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 2Faculty of Veterinary Medicine, Mansoura University, 3Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 4Laboratory of Veterinary Clinical Oncology, Faculty of Applied Biological Sciences, Gifu University, 5Center for Highly Advanced Integration of Nano and Life Sciences, Gifu University, 6Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 7Department of Veterinary Clinical Oncology, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 8Animal Medical Center, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 9Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 10Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, 11Pet Health & Food Division, Iskara Industry CO., LTD, 12Laboratory of Veterinary Anatomy, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology

P-82S Toxicologicaleffectsinadultmaleratsoftwo-hitexposuretotris(1,3-dichloro-2-propyl) phosphate (TDCIPP) at neonatal and adult stages ○ Takahiro AKIMOTO 1, Shohei KOBAYASHI1, 2, Shoichi ISOBE1, Taichi HATAKEYAMA1, 2, Ryo OHTA3, Rie YANAGISAWA4, Eiko KOIKE4, Noriyuki SUZUKI4, Maiko KAWAGUCHI1

1School of Agriculture, Meiji University, 2OSRI, Meiji University, 3Hatano Research Institute, 4Center for Health and Environmental Risk Research, National Institute for Environmental Studies

P-83E Optimization of assessment method for drug induced contractile response in human induced pluripotent stem cell-derived cardiac cell sheet-tissue○ Eriko KATO1, Yuto HINATA2, Yuki KAGAWA2, Hirotsugu KUBO2, Tomohiko TANIGUCHI3, Takashi YOSHINAGA3, Atsushi BABA1, Yuji IKEGAYA1, Kohei SAWADA1

1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2Ogino Memorial Laboratory, Nihon Kohden Corporation, 3Advanced Biosignal Safety Assessment, Eisai Co., Ltd.

Pro

gram

(e

-Pos

ter)

P-84S Similarity between the responses to antibacterial drugs in human iPSC-derivedneuronsandtheclassificationofantibacterialdrugencephalopathy in clinical○ Kazutoshi OGAWA, Yuto ISHIBASHI, Ikuro SUZUKI

Department of Electronics, Tohoku Institute of Technology

Alternatives to mammalian modelsP-85E A novel strategy combining Kao ITS and read-across to determine the

skin sensitization potency of cosmetic ingredients○ Kanako NAKAYAMA1, Anne GRANITZNY2, Sabrina FRITZ2, Anne FUCHS2, Masaaki MIYAZAWA1, Hitoshi SAKAGUCHI1

1Kao Corporation, Safety Science Research, 2Safety & Toxicology, Kao Germany GmbH

P-86S※ Development of in silico model for skin sensitization based on IATA (Integrated Approach on Testing and Assessment) approach○ Masaharu SUZUKI1, Kaori AMBE1, Masahiro TOHKIN1, Takashi YAMADA2, Takao ASHIKAGA2

1Regulatory Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, 2National Institute of Health Sciences Division of Risk Assessment

P-87E Integrated approaches to testing and assessment to assess photosensitization potential ~Establishment of photo-DPRA~○ Toshiyuki OHTAKE, Hayato NISHIDA, Morihiko HIROTA, Hirokazu KOUZUKI


P-88E Application to prediction for respiratory sensitization using in chemico Amino acid Derivative Reactivity Assay (ADRA) having developed for skin sensitization○ Sayaka WANIBUCHI, Yusuke YAMAMOTO, Toshihiko KASAHARA, Yasuhiro KATSUOKA, Masaharu FUJITA

Safety Evaluation Center, Ecology&Quality Management Division, ES G Division, Kanagawa, Japan

P-89E Examination of an internal threshold of toxicological concern (iTTC) for cosmetic use in the systemic toxicity assessment○ Takumi NUKAGA, Shuichi SEKINE, Tomoka HISAKI, Koki YOSHIDA, Takeshi HARIYA, Hirokazu KOZUKI

Safety and Analytics Center, SHISEIDO Global Inovation Center

P-90E Validation studies of IATA based read-across for developing alternative method of systemic toxicity○ Shota NAKAGAWA, Maiko OKAMOTO, Keita YOSHIHARA, Yuuko NUKADA, Osamu MORITA

Kao Corporation, Safety Science Research

P-91E ZebrafishembryodevelopmentaltoxicitytestusingICHS5referencecompounds -Investigation of the cause of false negative judgment by measuring the concentration in the embryo-○ Tasuku NAWAJI1, 2, Kaho MURAKAMI1, Takashi KURAKU1, Takeshi MATSUURA1, Masanori SEKI1, Hiroki TERAOKA2

1Chemicals Evaluation and Research Institute, Japan, 2School of Veterinary Medicine, Rakuno Gakuen University

Program

(e-P

oster)

P-92S Evaluation of the percutaneous toxicity of folpet using a 3-dimentional reconstructed humen epidermis model○ Kenta SHISHIDO1, Noriko KEMURIYAMA2, Hina MANDOKORO1, Ayako OGAWA3, Syuji OGAWA 2, Akari ABE1, Ayane YAMAGUCHI1, Kinuko UNO2, Katsuhiro MIYAJIMA1, 2, Dai NAKAE1, 2

1Department of Nutritional Science and Food Safety, Graduate School Agriculture, Tokyo University of Agriculture, 2Department of Food and Nutritional Science, Graduate School of Agriculture Tokyo University of Agriculture, 3Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences ,Tokyo University of Agriculture

Animal modelP-93S Investigation of CDAA and HF diet on liver and adipose tissue in SDT

fatty rats, obese type 2 dibetic animals○ Kouhei MANDAI1, Katsuhiro MIYAJIMA1, 2, 3, Ayane YAMAGUCHI1, Atsuya YAMAMOTO3, Nanami MACHIDA3, Maho MORITA3, Kenshiro IWAMOTO3, Noriko KEMURIYAMA3, Masami SHINOHARA4, Takeshi OHTA5, Dai NAKAE1, 2, 3

1Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture, 2Department of Food and Nutrition Science, Graduate School of Agriculture, Tokyo University of Agriculture, 3Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Tokyo University of Agriculture, 4Tokyo Animal & Diet Dept. CLEA Japan, Inc., 5Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University

Information technology, AI, and big dataP-94S※ In silico prediction of the inhibition activity of drug-metabolizing

enzymes in rat○ Riku TOHNO1, Mizuki NAKAMORI1, Kaori AMBE1, Masahiro TOHKIN1, Takamitsu SASAKI2, Kouichi YOSHINARI2

1Regulatory Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, 2School of Pharmaceutical Sciences, University of Shizuoka

P-95S The evaluation of repeated-dose toxicity based on a read-across method using molecular descriptors : a trial of 2-step approach○ Yoshihiro TOCHIKUBO1, Yoko KITSUNAI1, jun-ichi TAKESHITA2, Michiko WATANABE1, Takamitsu SASAKI1, Takuomi HOSAKA1, Ryota SHIZU1, Kouichi YOSHINARI1

1Department of Molecular Toxicology, School of Pharmaceutical Science, University of Shizuoka, 2Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan

P-96S※ Development of a prediction method for drug-induced liver injury by machine learning using large-scale adverse drug reaction data○ Waki TAKADA, Kaori AMBE, Masahiro TOHKIN

Regulatory Science, Graduate School of Pharmaceutical Sciences, Nagoya City University

P-97S QSAR modeling and characterization of drugs inducing liver cancer based on mutagenicity and molecular initiating event of AOPs○ Kota KUROSAKI, Yuhei MASHIYAMA, Shunichi SASAKI, Yasunari MATSUZAKA, Junko NAGAI, Yoshihiro UESAWA

Department of Medical Molecular Informatics, Meiji Pharmaceutical University

Pro

gram

(e

-Pos

ter)

Pharmaceutical drugs (chemicals)P-98 DoxorubicinhydrochloridecausedCardiactoxicitytozebrafish

embryos○ Xiaoyu YIN1, Yuxin DI1, Wuliji AO2, Liang XU3, Baoquan ZHAO4, Jiang DENG5, Jingfeng YANG1, Wu DONG1

1Inner Mongolia Key Laboratory of Toxicant Monitoring and Toxicant and Toxicology, Collage of Animal Science and Technology, Inner Mongolia University for Nationalities, 2College of Mongolian Medicine and Pharmacy /Inner Mongolia Research Institute of Traditional Mongolian Medicine Engineerling Technology, 3College of Chemistry and Chemical Engineering, Inner Mongolia University for the Nationalities, 4State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, 5Key Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical University

P-99 Suppressive mechanism of cold compress on cytotoxicity induced by mitomycin C○ Masaki TAKAISHI1, Megumi SASAKI1, Tatsuru HIRAGA1, Kana SATO1, Toshiaki TAKEDA2, Satoshi ASANO1

1Department of Pharmaceutical Sciences, International University of Health and Welfare, 2Faculty of Nursing, Iwate Prefectural University

P-100 Small-scale panel comprising diverse gene family targets to evaluate compound promiscuity○ Tomoya SAMESHIMA, Tomoya YUKAWA, Yoshihiko HIROZANE, Masato YOSHIKAWA, Taisuke KATOH, Hideto HARA, Takatoshi YOGO, Ikuo MIYAHISA, Teruaki OKUDA, Makoto MIYAMOTO, Russell NAVEN

Research, Takeda Pharmaceutical Company Limited

P-101 Developmentofaworkflowincorporating in silico approaches to assessthechronictoxiceffectsofpharmaceuticalsonalgae○ Masayuki KURIMOTO1, Takashi YAMADA1, Hiroshi YAMAMOTO2, Akihiko HIROSE1

1Division of risk assessment, National Institute of Health Sciences, 2Center for Health and Environmental Risk Research, National Institute for Environmental Studies

Regenerative medicine and cell therapyP-102 Tumorigenicity assessment of HeLa cells in nude rats

○ Taiki SUGIYAMA, Takamasa NUMANO, Hitomi HIGUCHI, Mayumi KAWABE, Hiroto MIYATA, Yukinori MERA

DIMS Institute of Medical Science, Inc.

Agricultural chemicalsP-104※ Organophosphate agent action at the brain endocannabinoid-

hydrolyzing enzymes leading to an ADHD-like behavior in adolescent male rats○ Yuki ITO1, Motohiro TOMIZAWA2, Kazutaka SUZUKI1, Yuichi SHIRAKAWA1, Hiromasa ONO1, Keishi ADACHI1, Himiko SUZUKI1, Kenji SHIMOMURA2, Toshitaka NABESHIMA3, Michihiro KAMIJIMA1

1Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences, 2Department of Chemistry, Faculty of Life Sciences, Tokyo University of Agriculture, 3Advanced Diagnostic System Research Laboratory, Fujita Health University

Program

(e-P

oster)

P-105 Assessmentofadversehealtheffectoftheherbicideglyphosateanditsformulations○ Junko KIMURA-KURODA

Environmental Neuroscience Information Center

P-106 Developmental immunotoxicity test of dinotefuran administered to mice in drinking water○ Aya SAIGA, Yukie TADA, Mari NAKAMURA, Motoki HOJO, Kiyomi IKUSHIMA, Ai MAENO, Katsuhiro YUZAWA, Yoshikazu KUBO, Hiroshi ANDO, Akemichi NAGASAWA, Kazuyoshi TANAKA, Toshinari SUZUKI, Akiko INOMATA, Takako MORIYASU

Tokyo Metropolitan Institute of Public Health

P-107 Neurotoxicity assessment using microelectrode array recordings in human iPSC-derived neurons○ Shigeru YAMADA1, 2, Kazunobu TSUNEMOTO1, Yasunari KANDA1

1Division of Pharmacology, National Institute of Health Sciences, 2Pharmacological Evaluation Institute of Japan

MetalsP-108 The modeling of metal exposome specialized for electrophilic metals

○ Masahiro AKIYAMA, Hiroto YAMAKAWA, Yoshito KUMAGAI Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba

P-109 Protective role of a lipocalin family protein C8 gamma against heavy metal toxicity: Characterization of the binding mode between C8 gamma and heavy metals○ Katsuya YAMAMOTO1, Iori TSUBAKIHARA1, Akiko IDO1, Hisamitsu NAGASE1, 2, Daisuke MATSUMARU1, Tsuyoshi NAKANISHI1

1Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 2School of Health Science, Gifu University of Medical Science

P-110 EffectofCr(III)onpreventionofinsulinresistanceinHepG2cells○ Kazuhiko NISHIMURA, Suzuka IITAKA, Hiroshi NAKAGAWA

Course of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University

P-111 Oleanolic acid-3-glucoside, a synthetic oleanane-type saponin, ameliorates methylmercury-induced neurotoxicity in vivo○ Ryosuke NAKAMURA1, Takashi IWAI2, Tatsuya SHIRAHATA3, Naruki KONISHI3, Yasukazu TAKANEZAWA1, Yuka OHSHIRO1, Shimpei URAGUCHI1, Mitsuo TANABE2, Yoshinori KOBAYASHI3, Masako KIYONO1

1Department of Public Health, School of Pharmacy, Kitasato University, 2Laboratory of Pharmacology, School of Pharmacy, Kitasato University, 3Department of Pharmacognosy, School of Pharmacy, Kitasato University

P-112 AmechanisminvolvedinmethylmercuryinducedTNF-αexpressioninmicroglia○ Takashi TOYAMA1, Takayuki HOSHI1, 2, Yoshiro SAITO1, Akira NAGANUMA1, Gi-Wook HWANG1, 2

1Graduate School of Pharmaceutical Sciences, Tohoku University, 2Tohoku Medical and Pharmaceutical University

Pro

gram

(e

-Pos

ter)

P-113 Relationship between blood erythropoietin and renal erythropoietin induction in rats exposed to cadmium○ Hyogo HORIGUCHI1, Etsuko OGUMA1, Yukiko YASUOKA2, Yuki OMORI1, Katsumasa KAWAHARA2, 3, Hiroshi NONOGUCHI4

1Department of Hygiene, Kitasato University School of Medicine, 2Department of Physiology, Kitasato University School of Medicine, 3Department of Health and Nutrition, Sendai Shirayuri Women’s College, 4Department of Internal Medicine, and Education and Research Center, Kitasato University Medical Center

P-114※ Uranium localization and tissue alteration in developing kidney○ Shino TAKEDA1, Akihiro UEHARA1, Masakazu OIKAWA1, Chiya NUMAKO2, Yasuko TERADA3, Izumi TANAKA1, Hiroshi ISHIHARA1

1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 2Graduate School of Science, Chiba University, 3Japan Synchrotron Radiation Research Institute

P-115 Structure-activity relationships for a zinc complex that exhibits cytotoxicity in vascular endothelial cells○ Tomoya FUJIE1, Taro YAMAMOTO1, Chika YAMAMOTO1, Toshiyuki KAJI2


Industrial chemicalsP-116 Whole body autoradiography in rats after percutaneous administration

of [14C]2-chloroaniline○ Yukie YANAGIBA, Tatsushi TOYOOKA, Rui-Sheng WANG, Shigeki KODA

National Institute of Occupational Safety and Health

P-117 Gene expression and histopathological analyses in the urinary bladder of rats treated with aromatic amines with similar structure to o-toluidine○ Takeshi TOYODA1, Takanori YAMADA1, 2, Kohei MATSUSHITA1, Tomomi MORIKAWA1, Kumiko OGAWA1


P-118※ Effectsof4-or5-methyl-2-mercaptobenzimidazoleonCYPactivityinprimary cultured rat hepatocytes○ Atsuko MIYAJIMA1, Yukie KURODA2, Kazue SAKEMI-HOSHIKAWA2, Momoko SUNOUCHI2, Katsuyoshi MITSUNAGA3, Tomohiko IRIE2, Yasuo OHNO2, 4, Makoto USAMI2, 5

1Division of Medical Devices, National Institute of Health Sciences, 2Division of Pharmacology, National Institute of Health Sciences, 3School of Pharmaceutical Sciences, Toho University, 4Kihara Memorial Yokohama Foundation for the Advancement of Life Sciences, 5Graduate School of Veterinary Medicine, Azabu University

Foods, food additives, and food contaminantsP-119 Preparation of mycotoxin-derived metabolites using yeast expressing

drug-metabolizing enzymes○ Miharu FUJII1, 2, Miyu NISHIKAWA1, 4, Takahiro IEKO3, Jumpei FUJIKI3, Hidetomo IWANO3, Shinichi IKUSHIRO4, Toshiyuki SAKAKI5

1TOPU BIO RESEARCH Co.,Ltd, 2KOKANDO Co.,Ltd, 3Department of Veterinary Medicine, School of Veterinary Medicine, Rakuno Gakuen University, 4Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5Department of Pharmaceutical Engineering, Faculty of Engineering, Toyama Prefectural University

Program

(e-P

oster)

P-120 The relationship between acrylamide-induced DNA adducts and, mutagenicity and carcinogenesity○ Yuji ISHII1, Shinji TAKASU1, Kenji NAKAMURA1, Aki KIJIMA1, Kumiko OGAWA1, Takashi UMEMURA1, 2

1Division of Pathology, National Institute of Health Sciences, 2Faculty of Animal Health Technology, Yamazaki University of Animal Health Technology

Environmental pollutantsP-121 Biomonitoring PAHs pollution in the coastal sediments of the Bohai

Bay, China ○ Wenjing DONG1, Binrong BAI1, Jingli MU2, Desheng PEI3, Na ZHENG4, Lingtian XIE5, Jingfeng YANG1, Wu DONG1

1Collage of Animal Science and Technology, Inner Mongolia University for Nationalities, 2Institute of Oceanography, Minjiang University, China, 3Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, China, 4College of Environment and Resources, Jilin University, China, 5SCNU Environmental Research Institute, South China Normal University, China

P-122 Theeffectsofcigarettesmokeexposureonbleomycin-inducedlunginjury in rats○ Min-Seok KIM1, Young-Jun SHIN1, Yong-Hyun KIM1, YongJae KIM1, Seon-Hee BAE1, Gyu-Hwan BAE1, Young-Ji AN1, Kyung-Chul CHOI2, Sung-Moo LEE2, Ryeo‐Eun GO2

1Inhalation Toxicology Research Group, Jeonbuk Branch Institute, Korea institute of Toxicology, 2Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea

P-123 Structure-specificcharacterizationofparametersusedinPhysiologically Based Pharmacokinetic (PBPK) modeling of environmental chemicals○ Kikuo YOSHIDA1, Yuriko MEISEKI1, Saori MATSUMOTO1, Seiichi ISHIDA2, Takashi YAMADA1

1Division of Risk Assessment, National Institute of Health Sciences, 2Division of Pharmacology, National Institute of Health Sciences

P-124 Additive or synergistic activation of Keap1/Nrf2 pathway and enhancement of toxicity by combined exposure to environmental electrophilesHanako AOKI2, ○ Yumi ABIKO1, 2, Yusuke ONOSE2, Yoshito KUMAGAI1, 2

1Faculty of Medicine, University of Tsukuba, 2Graduate School of Comprehensive Human Sciences, University of Tsukuba

P-125 IdentificationofthecellsexpressingTNFreceptor3inmousebrain, and its role on methylmercury- induced neuronal damage○ Yohei TSUNODA1, 2, Takashi TOYAMA1, Akira NAGANUMA1, Yoshiro SAITO1, Gi-Wook HWANG1, 2

1Graduate School of Pharmaceutical Sciences & Faculty of Pharmaceutical Sciences, Tohoku University, 2Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University

P-126 EffectsofUVc-irradiatednylonpowdersonalgaecellsPseudokirchneriella subcapitata○ Satomi Mizukami MURATA1, Suntae LEE1, Yuji SUZUKI1, Shouta ABE2, Hiromasa YAMASHITA1

1Public Works Research Institute, 2entex Inc

Pro

gram

(e

-Pos

ter)

P-127 VisualizationofhormonelikeactivitiesinwaterusinggenemodifiedDaphnia magnaYasuhiko KATO, Ayano NODA, Nikko ADHITAMA, ○ Hajime WATANABE

Department of Biotechnology, Osaka University

Endocrine disruptorsP-128 Detection of juvenile hormone-like compounds using yeast reporter

assay for juvenile hormone receptor of Daphnia magna○ Masahiro OGAWA1, 2, Sayoko ITO-HARASHIMA2, Kenta KITAZUMI1, Takahiro KYOYA1, Megumi TERADA1, Masanobu KAWANISHI2, Takashi YAGI2

1Life Science Research Institute, Kumiai Chemical Industry Co., Ltd., 2Department of Biological Science, Graduate School of Science, Osaka Prefecture University

NanomaterialsP-129 Evaluation of metal nanoparticles in serum of rats treated with ITO

nanoparticles by Single Particle (SP)-ICP-MS○ Kyoko KOBAYASHI1, Akiyo TANAKA2, Nagisa MATSUMURA2, Chady STEPHAN3

1PerkinElmer Japan Co., Ltd.,, 2Graduate School of Medical Sciences, Kyushu University, 3PerkinElmer Inc.

P-130※ Chronic toxicity study of multi-walled carbon nanotubes (MWCNT) in rats by repeated intratracheal instillations: a progress report at 1 year○ Ai MAENO1, Motoki HOJO1, Yoshimitsu SAKAMOTO1, Katsuhiro YUZAWA1, Yuko HASEGAWA1, Yoshikazu KUBO1, Akemichi NAGASAWA1, Hiroshi ANDO1, Kazuyoshi TANAKA1, Fujifumi KAIHOKO1, Kiyomi IKUSHIMA1, Yukio YAMAMOTO1, Toshinari SUZUKI1, Akiko INOMATA1, Takako MORIYASU1, Yuhji TAQUAHASHI2, Satoshi YOKOTA2, Norihiro KOBAYASHI2, Akihiko HIROSE2, Dai NAKAE3

1Tokyo Metropolitan Institute of Public Health, 2National Institute of Health Sciences , 3Tokyo University of Agriculture

P-131※ Identificationofachemicalthatrepressesmultiwallcarbonnanotube-stimulatedIL-1βproduction○ Tomoko NISHIMAKI-MOGAMI, Hongyan CUI, Keisuke SOGA, Norimasa TAMEHIRO, Reiko ADACHI, Akiko HACHISUKA, Akihiko HIROSE, Kazunari KONDO


P-132 Assessmentofthepulmonarytoxicpotentialofcellulosenanofibers○ Katsuhide FUJITA, Sawae OBARA, Junko MARU, Shigehisa ENDOH

Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology

P-133※ The role of Ca2+ signaling from lysosomes in the toxic mechanism for titanate nanosheets○ Yasumitsu NISHIMURA1, Daisuke YOSHIOKA2, Naoko KUMAGAI-TAKEI1, Suni LEE1, Kei YOSHITOME1, Tatsuo ITO1, Takemi OTSUKI1

1Department of Hygiene, Kawasaki Medical School, 2Department of Natural Sciences

Program

(e-P

oster)

Nervous systemP-134 An attempt to establish the evaluation system for drug-induced epilepsy

by applying microelectrode array recording -activity report from CSAHi Neuro group○ Takafumi SHIRAKAWA1, 2, Norimasa MIYAMOTO1, 3, Yuto ISHIBASHI1, 4, Kaoru SATO1, 5, Nobuo AIKAWA1, 6, Atsuko OJIMA1, 3, 7, Aoi ODAWARA1, 4, Hiromi KASHIWAZAKI1, 8, Takashi KOYAMA1, 8, Hiroyuki ABE1, 9, Daisuke SAJI1, 9, Maya TAMURA1, 10, Masami KATO1, 11, Akiko PAWLAK1, 11, Daiki SHIMATO1, 11, Wigyon SHIN1, 12, Kaoru MORIMURA1, 12, Ikuro SUZUKI1, 4

1Consortium for Safety Assessment using Human iPS Cells (CSAHi), 2Astellas Pharma Inc., 3Eisai Co., Ltd., 4Tohoku Institute of Technology, 5Laboratory of Neuropharmacology, Division of Pharmacology, National Institute of Health Sciences, 6Kyowa Kirin Co.,Ltd., 7TechnoPro, Inc. TechnoPro R&D, Company, 8Otsuka Pharmaceutical Co.,Ltd., 9NISSEI BILIS CO., LTD., 10Axcelead Drug Discovery Partners Inc., 11Nihon Bioresearch Inc., 12FUJIFILM Corporation

P-135※ In vitro model for axonal injury and functional recovery in microengineered human iPSC-derived neuronal networks○ Waka LIN1, Shusaku SHIOMOTO1, Koichi MURAMATSU1, Kohei SAWADA2

1Biomedical Research Department, Healthcare Business Group, RICOH Company, Ltd., 2Social Cooperation Program of Evolutional Chemical Safety Assessment System, Graduate School of Pharmaceutical Sciences, The University of Tokyo

P-136 Trials for simple neuronal Ca-transient analysis using human iPS cell-derivedneuronstoassessthetoxiceffectsoncentralnervoussystem○ Takuya KONDO1, 2, Shohei KANIE1, Kazuhiko BESSHI1

1TAIHO PHARMACEUTICAL CO., LTD., 2Consortium for Safety Assessment using Human iPS Cells (CSAHi)

P-137※ Comparison and utility of animal species for convulsion risk assessment○ Motohiro SHIOTANI1, Yuki SEKI1, Misato TAKANO1, Hiroki ISHIHARA3, Sanae MAEDA2, Tomohiko TANIGUCHI2, Masaki MIKAMOTO4, Yoshitane NOZAKI4, Norimasa MIYAMOTO2, Takashi YOSHINAGA2, Shoji ASAKURA1

1Global Drug Safety, Eisai Co., Ltd., 2Advanced Biosignal Safety Assessment, Eisai Co., Ltd., 3Tsukuba Discovery Reliability Assurance, Eisai Co., Ltd., 4DMPK Tsukuba, Eisai Co., Ltd.

P-138 Tissue clearing by RAP system is available for immunohistochemistry○ Hiromi SAKATA1, Maimi UCHISHIBA2, Tsuyoshi TSUKADA1, Daisuke SAKAI4, Hiroki SHIMADA1, 3, Hiroki SHOJI4, Toshihisa HATTA1

1Department of Anatomy, Kanazawa Medical University, 2Hidaka Hospital, 3Department of Medical Science, Kanazawa Medical University, 4Department of Biology, Kanazawa Medical University

P-139 High-throughput drebrin immunocytochemical analysis using a confocal quantitative image cytometer for detecting NMDA receptor activation of cultured rat hippocampal neurons○ Shogo MASE1, 2, Yuko SEKINO1, Tomoaki SHIRAO2, Toshinari MITSUOKA1

1Endowed Laboratory of Human Cell-Based Drug Discovery, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine

P-140※ Responses to convulsants in human cerebral cortical organoidsAoi ODAWARA, Naoki MATSUDA, Yuto ISHIBASHI, Remi YOKOI, ○ Ikuro SUZUKI

Tohoku Institute of Technology

Pro

gram

(e

-Pos

ter)

LiverP-141 Possibility of drug-drug interactions resulted from enzyme inhibition of

Juzen-taiho-to in dogs○ Yuta SHINOHARA1, 2, Tatsuya USUI1, Kazuaki SASAKI1

1Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 2Pet Health & Food Division, Iskara Industry CO., LTD

P-142 Physicochemicalandinvitroprofilingofcompoundswithhepatotoxicityobserved in clinical studies○ Masamitsu ANDO1, Yumi HASHINO1, Takahiro GOTO2, Manami MIYAKE3, Chinami ARUGA1, Tomomi TANIGUCHI1

1 Discovery Technology Laboratories, Mitsubishi Tanabe Pharma Corporation, 2DMPK Research Laboratories, Mitsubishi Tanabe Pharma Corporation, 3Safety Research Laboratories, Mitsubishi Tanabe Pharma Corporation

P-143※ Predictive and mechanistic in vitro assays for identifying DILI potential in early phase of drug development○ Hiroshi KOHARA1, Piyush BAJAJ2, Tomoya YUKAWA2, Hideto HARA1, Kousuke HARADA1, Kazumasa MIYAMOTO1, Shigeru IGAKI1, Matthew WAGONER2, Russell NAVEN3, Makoto MIYAMOTO1, Tadahiro SHINOZAWA1

1Takeda Pharmaceutical Company Limited, 2Takeda Pharmaceutical Company Limited. Cambridge, 3Takeda Pharmaceutical Company Limited. California

P-144 Comprehensive gene expression analysis of non-obese-type of non-alcoholic steatohepatitis and simple steatosis in mice○ Noriko KEMURIYAMA1, Akari ABE2, Sumire HIDAKA1, Ikumi SADATOME1, Kinuko UNO3, Hina MANDOKORO2, Ayane YAMAGUCHI2, Syuji OGAWA3, Atsushi WATANABE3, Megumi YUKI1, 4, Katsuhiro MIYAJIMA1, 2, 3, Dai NAKAE1, 2, 3

1Dept. Nutr. Sci. Food Safety, Facul. Biosci., Tokyo Univ. Agricul., 2Dept. Nutr. Sci. Food Safety, Grad. Sch. Agricul., Tokyo Univ. Agricul., 3Dept. Food Nutr. Sci., Grad. Sch. Agricul., Tokyo Univ. Agricul., 4New Histo Science Labratory Co., Ltd.

KidneyP-145※ Protection of L-carnitine in autophagy-mediated cell apoptosis through

ROS/pERK1/2-dependent pathway in PFOS-treated RTC cells○ Shu-Hui JUAN1, Yen-Ting CHEN1, Tsui-Ling KO2, Hsiu-Chu CHOU3

1Department of Physiology, Taipei Medical University, 2School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, Taiwan, 3Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

P-146 Ultrasonographic measurement of the renal resistive index in the cynomolgus monkey (Macaca fascicularis) under conscious and ketamine-immobilized conditions○ Hiroya KONNO


Program

(e-P

oster)

P-147 Comprehensive expression analysis of mRNA and microRNA for investigation of compensatory mechanisms in the rat kidney after unilateral nephrectomy○ Kohei MATSUSHITA1, Takeshi TOYODA1, Takanori YAMADA1, 2, Tomomi MORIKAWA1, Kumiko OGAWA1


SkinP-148 Quantifiedmethodforassessmentofdryskinanditch

- Atopic dermatitis induced by diet and mite antigen in hairless mice -○ Manami NAGAYAMA, Ayaka YAMAGUCHI, Ryota YAGI, Kumiko KITTA, Atsuko ICHIKAWA, Junichi FUCHIKAMI, Yasuki AKIE

CMIC Pharma Science Co., Ltd.

Sensory organP-149 Nonclinical safety assessment of ophthalmic pharmaceuticals: Survey

of disclosed common technical documents for drugs approved in Japan○ Masayuki TOMOHIRO

INERS Nonclinical Eye Research Service

P-150 ThespeciesdifferenceofreactivitytoTRPchannelagonistsinstillation○ Masato TADAKI, Yoshihiko ESAKI, Takahisa NOTO, Hidetoshi MANO

Pharmaceutics & Pharamacology Department, Global R&D, Santen Pharmaceutical Co., Ltd.

P-151※ Influenceofexposuretolowfrequencynoiseonbalanceinmice○ Nobutaka OHGAMI, Kazunori HASHIMOTO, Akira TAZAKI, Masashi KATO

Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine

P-152 Development of an intratympanic dosing method for evaluation of ototoxicity in guinea pigs○ Tetsuya YOSHIKAWA, Minoru MISHIMA, Hideki NISHI, Mitsumi TAURA, Mie UCHIMURA, Takaharu NAGAOKA, Hideshi TSUSAKI


Respiratory systemP-153 Development of an in vitro test for respiratory sensitization using a

co-culture system of human bronchial epithelium and antigen-presenting cellsKunitaka YOSHIDA1, ○ Shinkichi ISHIKAWA1, Tsuneo HASHIZUME1, Takao ASHIKAGA2

1Scientific Product Assessment Center, R&D Group, Japan Tobacco Inc., 2Division of Risk Assessment, National Institute of Health Sciences

P-154 Proliferation of pulmonary endocrine cell in rats after a long-term intratracheal instillation of multi-wall carbon nanotube (MWCNT)○ Yoshimitsu SAKAMOTO1, Motoki HOJO1, Ai MAENO1, Toshinari SUZUKI1, Akiko INOMATA1, Takako MORIYASU1, Akihiko HIROSE2, Dai NAKAE3

1Tokyo,Metropol. Inst.Pub.Health, 2Natl. Inst. Health Sci., 3Tokyo Univ. Agricul.

Pro

gram

(e

-Pos

ter)

Cardio vascular systemP-155 Evaluation using heart rate-corrected blood pressure

○ Akihito ITO, Tomoko NAGAO, Masashi YAMAMOTO, Hironobu IKEDA, Takeshi IIDAKA, Hiroshi SAKONJO

NISSEI BILIS Co. Ltd.

P-156 Drug responses of AscleStem® Cardiomyocytes derived from nomal humaniPScellsdifferentiatedby3Dembryoidbodyformationprotocol○ Nobuhiro MORIMOTO, Kenji YOSHIMOCHI, Koji HASHIDA, Yugo OKAZAKI, Motoshi SHIMOTSUMA

Nacalai Tesque, Inc.

P-157 Development of cardiotoxicity assessment method for molecularly targeted drugs in mice -From the viewpoint of cardio-oncology-○ Fumiyuki NAKANE1, Maki TAKAHASHI1, Hiroyuki SAITO1, Ayano SUEOKA1, Kumiko KITTA1, Miyuki TAKAO1, Atsuko ICHIKAWA1, Suguru HANARI2, Eiji TAKAHARA2, Yasuki AKIE1, Atsushi SUGIYAMA3

1CMIC Pharma Science Co.,Ltd. CMIC Bioresearch Center, 2CMIC Pharma Science Co., Ltd. Kobe Laboratory, 3Department of Pharmacology, Faculty of Medicine, Toho University

P-158 Development of contractility assessment using engineered heart tissue○ Daiju YAMAZAKI


P-159※ Usability of blood pressure, heart rare, body temperature, and electrocardiogram of miniature pig using emka TECHNOLOGIES telemetry system○ Hironobu IKEDA, Masashi YAMAMOTO, Tomoko NAGAO, Akihito ITO, Takeshi IIDAKA

NISSEI BILIS Co., Ltd., Shiga Laboratory

P-160 Functional improvement of contractile force properties of human iPS cell-derived cardiac cell sheets by continuous stimulation for several days○ Tomohiko TANIGUCHI1, Yuto HINATA2, Yuki KAGAWA2, Eriko KATO3, Atsushi BABA3, Hirotsugu KUBO2, Takashi YOSHINAGA1, Kohei SAWADA3

1Advanced Biosignal Safety Assessment, Eisai Co., Ltd., 2Ogino Memorial Laboratory, Nihon Kohden Corporation, 3Graduate School of Pharmaceutical Sciences, The University of Tokyo

P-161 Evaluation of autonomic nervous function and QT prolongation using Heart rate variability (HRV) in cynomolgus monkey○ Hiroyuki SAITO, Tadashi KAKOI, Chihiro YAMADA, Kiyotaka HOSHIAI, Yasuki AKIE

CMIC Pharma Science Co., Ltd. CMIC Bioresearch Center

Reproductive systemP-162※ EffectsofexcessivevitaminAonhepaticandtesticulartoxicityinmice

○ Satoshi YOKOTA1, Takuya SHIRAHATA2, Nao SEKINE2, Shigeru OSHIO2

1Division of Cellular & Molecular Toxicology, Center for Biological Safety & Research, National Institute of Health Sciences, 2Department of Hygiene Chemistry, Ohu University School of Pharmaceutical Sciences

Program

(e-P

oster)

P-163 Induction of testicular dysfunction by circadian rhythm dysregulation○ Nobuhiko MIURA1, Katsumi OHTANI2, Satoshi YOKOTA3, Hiroki YOSHIOKA4, 5

1Yokohama University of Pharmacy, 2National Institute of Occupational Safety and Health Japan, 3National Institute of Health Sciences, 4College of Pharmacy, Kinjo Gakuin University, 5The university of Texas Health Science at Houston

Endocrine systemP-164 In vitro non-radioactive uptake assay development of human NIS

over-expressed HEK293 cell lineImola Eszter JUHASZ2, ○ Nora SZILVASY1, Beata Martonne TOTH1, Zsuzsanna GABORIK1, Peter KOVACS1, Eszter Patakine ILLES1

1R&D, SOLVO Biotechnology Inc., 2Service Support, SOLVO Biotechnology Inc.

P-165 The change of fetal thyroid hormone level caused by increased metabolism of thyroid hormone in maternal liver○ Mariko SHIMADA, Satoko DOI, Kenta MINAMI, Takafumi YAMAGUCHI, Tokuo SUKATA

Environmental Health Science Laboratory, SUMITOMO CHEMICAL Co., Ltd.

Other organs or systemP-166 Skeletal muscle lesions in rats following 4-week repeated orally

administration of zinc pyrithione○ Yukari NISHIMURA, Fumika AKIZAWA, Koji DOGISHI, Takayasu MOROKI, Satoshi KONDO, Yuki INOUE

Otsuka Pharmaceutical Co., Ltd. Tokushima Research Institute, Nonclinical Research Center, Department of Drug Safety Research

P-167 Optimal dispersion of submicron-sized silica quartz for in vivo toxicity studies○ Kenichi KOBAYASHI, Hisayo KUBOTA, Yukie YANAGIBA, Katsumi OHTANI, Maromu YAMADA, Mitsutoshi TAKAYA

National Institute of Occupational Safety and Health, Japan

General toxicologyP-168 Sub-chronic oral toxicity assessment of TGT Primaage in wistar rats

○ Manish V. PATEL1, Kunjan SHAH1, Sudhkar JADHAV1, Liliya KONG2

1Jai Research Foundation, 2The Mitomasa Sdn Bhd

P-169 Protectiveeffectofsulforaphaneagainstacrylamide-inducedneuropathy in adult mice○ Chand Basha DAVULJIGARI, Adams Frederick EKUBAN, Cai ZONG, Kouta MORIKAWA, Gaku ICHIHARA

Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan

P-170 Evaluation of vehicles for poorly soluble compounds in rat oral dose toxicity study○ Keigo IKEDA, Yasuhiro SASAKI, Kumiyo OKADA, Hiroshi INADA, Izuru MIYAWAKI

Sumitomo Dainippon Pharma Co., Ltd

Pro

gram

(e

-Pos

ter)

P-171 Thresholds of biomarkers for skipping histopathological examination of the liver in mice○ Miharu SOEDA, Yutaka TONOMURA, Yuki NISHIKAWA, Yoko KITSUNAI, Takashi KOTERA, Shizuka KONISHI, Shino KUMABE, Tatsunobu MATSUI, Yuki NUMAKURA, Kentaro OKAMOTO, Hiroshi SHIBAYAMA, Makoto UEDA, Keiichiro SATO, Yasuhiro YAMASHITA

Pharmacokinetics and Safety Assessment Dept. Discovery Research Labs.

P-172 Relationship between body weight and hematological and biochemical parameters in cynomolgus monkeys○ Kazuaki TAKAHASHI, Junko SATO, Dai YAMAMOTO, Norio HIKE, Tatsumi TAKAKI, Hiroyuki ISHII, Takayuki OKAMURA, Seiji OTAKE

LSI Medience Corporation

P-173 Effectsofhemodilutionbasedonestrogendominanceonhematologicalresults in rats treated with Mifepristone○ Ikuro TAKAKURA, Tomoyuki KISHIDA, Shohei KOBAYASHI, Masaoki KAJINO, Takaya KUTSUKAKE, Yoshimasa MARUYAMA, Tetsuaki TAKAHASHI, Chizuru NISHIYAMA, Yamato MIYAJIMA, Ryohei YOKOI, Shinji SOMA

Toxicology, Safety Research Laboratory, Kissei Pharmaceutical Co., Ltd.

P-174 Effectsofinhalationalanestheticssevofluraneonhematologicalandblood biochemical examination in rats○ Ayahito KIMURA, Hitomi MATSUDA, Shoko KOSUGI, Shotaro HORI, Takeshi IIDAKA

NISSEI BILIS Co., Ltd.

P-175 Usefulness of a temperature-sensing microchip compared with traditional rectal thermometers in monkeys and dogs○ Haruka NISHIYA1, Hiroshi MIZUNO2, Katsuya ENJOJI1, Kenichi NORITAKE1

1Drug Safety & Animal Care Technology Unit, Tsukuba R&D Supporting Division, Sunplanet Co., Ltd., 2Advanced Biosignal Safety Assessment, BA CFU, Medicine Development Center, Eisai Co., Ltd.

Reproductive and developmental toxicologyP-176 CombinedeffectsofmaternalexposuretofungicidesinF1-generation

mice: Fixed-dose study of thiabendazole○ Toyohito TANAKA1, Toshinari SUZUKI1, Akiko INOMATA2, Takako MORIYASU2

1Division of Toxicology, Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health, 2Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health

P-177 Placental transfer of 125iodinatedhumanizedimmunoglobulinG2Δainthe cynomolgus monkey○ Yuji ISOBE1, Natasha R. CATLIN2, Denise M. O'HARA3, Mengmeng WANG3, Minlei ZHANG3, Christopher J. BOWMAN2

1DSRD-Tokyo, Drug Safety Research & Development, Pfizer R&D Japan, 2Pfizer Inc., Groton, CT, USA, 3Pfizer Inc., Andorver, MA, USA

Program

(e-P

oster)

P-178 Intrauterine hypo-perfusion model for reproductive and developmental toxicology○ Atsuto ONODA1, 2, 3, Yuma KITASE1, 4, Masahiro TSUJI5, Kazuto UEDA1, Masahiro HAYAKAWA1, Yoshiaki SATO1

1Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, 2Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University, 3Research Fellow of Japan Society for the Promotion of Science, 4Johns Hopkins University, 5Faculty of Home Economics, Kyoto Women’s University

P-179 Chemical and structural properties of substances with developmental neurotoxicity riskTakaho ASAI1, ○ Kouichi YOSHINARI1, Takamitsu SASAKI1, Takuomi HOSAKA1, Ryota SHIZU1, Yasunari KANDA2

1Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 2Division of Pharmacology, National Institute of Health Sciences

P-180※ CRISPR/Cas9-mediated genome editing of mouse zygotes induces diverse on-target unintentional mutations○ Toshime IGARASHI, Yukuto YASUHIKO, Ryuichi ONO, Erika TACHIHARA, Yu TAKAHASHI, Makiko KUWAGATA, Satoshi KITAJIMA

Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences

P-181 Development and characterization of a new database on reproductive and developmental toxicity of chemicals○ Minoru MIURA1, Masayuki KURIMOTO1, Tomoko KAWAMURA1, Kazuo USHIDA1, Kaoru INOUE1, Takashi YAMADA1, Makiko KUWAGATA2, Akihiko HIROSE1

1National Institute of Health Sciences, Division of Risk Assessment, 2National Institute of Health Sciences, Division of Cellular and Molecular Toxicology

P-182 Developmental toxicity study of immunosuppressive drug, azathioprine inrats:Effectsofasingletreatmentduringtheorganogenesis○ Yoshiki BAN, Miku IINO, Aya KANNO, Yuuki MIYAZAKI, Masao HORIMOTO

Department of Animal Risk Management, Chiba Institute of Science

P-183 Developmentalexposureeffectofaluminumchlorideonhippocampalneurogenesis in rats○ Satomi KIKUCHI1, 2, Hiromu OKANO1, 2, Yasunori TAKAHASHI1, 2, Kazumi TAKASHIMA1, 2, Risako YAMASHITA1, Mio KOBAYASHI1, Toshinori YOSHIDA1, 2, Makoto SHIBUTANI1, 2


P-184 Developmentalexposureeffectofleadacetateonhippocampalneurogenesis in rats○ Risako YAMASHITA1, Yasunori TAKAHASHI1, 2, Satomi KIKUCHI1, 2, Hiromu OKANO1, 2, Kazumi TAKASHIMA1, 2, Mio KOBAYASHI1, Toshinori YOSHIDA1, 2, Makoto SHIBUTANI1, 2


Pro

gram

(e

-Pos

ter)

Genetic toxicologyP-185※ The N7-glycidamideadductof2′-deoxyguanosineonthetemplate

strand induces DNA replication inhibition and mutagenesis in human cells○ Jun-ichi AKAGI1, Masayuki YOKOI2, Young-Man CHO1, Shigenori IWAI3, Fumio HANAOKA4, 5, Kaoru SUGASAWA2, Kumiko OGAWA1

1Div. Pathol., Natl. Inst. Health Sci., 2Biosignal Res. Ctr., Kobe Univ., 3Div. Chem., Grad. Sch. Eng. Sci., Osaka Univ., 4Dept. Life Sci., Fac. Sci., Gakushuin Univ., 5Natl. Inst. Genet.

P-186 Study on DNA damage property of 4-Chloro-o-toluidine and its underlying mechanism○ Hiroki KASHIWAGI, Tatsushi TOYOOKA, Rui-Sheng WANG, Shigeki KODA

National Institute of Occupational Safety and Health, Japan

P-187 γH2AXanalysisforassessmentofthegenotoxicityofrespirablecrystallin silica○ Tatsushi TOYOOKA1, Jingbo ZHANG2, Yonggang QI1, 3, Maromu YAMADA1, Rui-Sheng WANG1, Shigeki KODA1

1National Institute of Occupational Safety and Health, 2Shanghai Pulmonary Hospital, 3Kitasato University

CarcinogenicityP-188 Promotioneffectsofacetoaceto-ο-toluidideonN-butyl-N-(4-

hydroxybutyl)nitrosamine-induced bladder carcinogenesis in rats○ Min GI1, 2, Nao YUKIMATSU2, Shugo SUZUKI2, Anna KAKEHASHI2, Hideki WANIBUCHI2

1Department of Environmental Risk Assessment, Osaka City University Graduate School of Medicine, 2Department of Molecular Pathology, Osaka City University Graduate School of Medicine

P-189 Mode of action and human relevance for Amisulbrom-induced rodent liver tumors○ Seigo HAYASHI, Kei KUSAKARI, Masayuki KIMURA, Chisato HAYAKAWA, Yusuke KURODA, Kazuya TAKEUCHI, Satoshi FURUKAWA

Toxicology and Environmental Science Department, Nissan Chemical Corporation

P-190 Carcinogenic susceptibility comparative study on rasH2 mice produced by two breeding facilities○ Ryo INOUE, Masahiko YASUDA, Eiko NISHINAKA, Chiyoko NISHIME, Hideyuki HAGA, Misa MOCHIZUKI, Kenji KAWAI, Koji URANO

Central Institute for Experimental Animals

Behavioral toxicologyP-191※ Meta-analysis in neurobehavioral toxicology (No 6): Current status of

neurotoxicity evaluation of pesticides (insecticides) in Japan○ Hiroaki TAKAHASHI1, Masahito WATANABE1, Yukiko FUETA1, 2, Naoto NITTA1, Yoshimasa HAMADA1

1Independent Collegium for Regulatory Science, 2Univ. Occup. & Environ. Health, School of Health Scis.

Program

(e-P

oster)

CytotoxicityP-192※ InhibitoryeffectsofAntrodiacinnamomeaextractonproliferationand

metastasis of endometrial cancer cells○ Tsui Ling KO1, Tzu Hsien CHANG2, Ya Ling CHEN3, Hsia Fen HSU2, Chi Chang CHANG1, 3, Jer Yiing HOUNG2, 4

1School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, Taiwan, 2Department of Nutrition, College of Medicine, I-Shou University, Kaohsiung, Taiwan, 3Department of Obstetrics & Gynecology, E-Da Dachang Hospital, Kaohsiung, Taiwan, 4Department of Chemical Engineering, I-Shou University, Kaohsiung, Taiwan

P-193 The factors involved in increasing arsenite sensitivity in SRSF5 siRNA knockdown HaCaT cells○ Daigo SUMI, Ai TAKASE, Rio FUJINAGA, Seiichiro HIMENO

Faculty of Pharmaceutical Sciences, Tokushima Bunri University

P-194 Erythropoietin promotes the proliferation of Human Leukemia U937 cells○ Haruna TANAKA, Kazuhiko NISHIMURA, Hiroshi NAKAGAWA

Laboratory of Toxicology, Course of Veterinary Science, Department of Life and Environmental Science, Osaka Prefecture University

P-195 Evaluation of the predictive performance for in vivo toxicity with high content analysis data○ Yoko KITSUNAI, Yutaka TONOMURA, Takashi HORIUCHI, Takashi KOTERA, Shizuka KONISHI, Shino KUMABE, Yuki NUMAKURA, Makoto UEDA, Keiichiro SATO, Yasuhiro YAMASHITA

Pharmacokinetics and Safety Assessment Dept., Discovery Research Labs., Nippon Shinyaku Co., Ltd.

P-196 Analysis of cytotoxic mechanism of Amiloride in HepG2 cells○ Shizuka HARA, Kazuhiko NISHIMURA, Hiroshi NAKAGAWA


P-197※ Machine learning of high content analysis data to predict drug-induced liver injury○ Yosuke SANUKI1, Tetsuro ARAKI2, Satoru KAWAKAMI1, Osamu NAKAZONO1

1Lab. for Safety Assessment & ADME, Pharmaceuticals Research Center, Asahi-kasei Pharma Corporation, 2Lab. for Drug Discovery, Pharmaceuticals Research Center, Asahi-kasei Pharma Corporation

P-198 Evaluationoftheeffectsofpolystyreneparticlesonautophagypathwayand exosome secretion in Caco-2 cells○ Hiroshi NAKAGAWA, Kazuhiko NISHIMURA

Laboratory of Toxicology, Course of Veterinary Science, Graduate School of Life and Environmental Biosciences, Osaka Prefecture University

P-199 Effectsofautophagyinductionbylowconcentrationofarsenateonsurvival and erythropoietin production in HepG2 cells○ Reo INOUE, Kazuya OGAWA, Naoki KIRIYAMA, Kazuhiko NISIMURA, Hiroshi NAKAGAWA


Pro

gram

(e

-Pos

ter)

Oxidative stressP-200※ Regulation of the glucose metabolic enzymes by oxidative stress

response factor Nrf2○ Rika SAKUMA, Syunsuke KOFUJI, Susumu IMAOKA


InflammationP-201※ Atriplex nummularia extract suppresses RANKL-activated

osteoclastogenesis○ Tsui Ling KO1, Han Chun KUO2, 3, Jyh Ferng YANG2, Chi Chang CHANG1, 4, Shih Wei WANG1, 2, 3, Jer Yiing HOUNG2, 5

1School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, Taiwan, 2Department of Chemical Engineering, I-Shou University, Kaohsiung, Taiwan, 3Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, E-DA Hospital, Kaohsiung, Taiwan, 4Department of Obstetrics & Gynecology, E-Da Dachang Hospital, Kaohsiung, Taiwan, 5Department of Nutrition, I-Shou University, Kaohsiung, Taiwan

Mechanisms of toxicityP-202 Up-regulationmechanismsoffattyacid2-hydroxylase(FA2H)byΔ9-

tetrahydrocannabinol:EvidenceforthePPARαandPPARβ/δinteractionin MDA-MB-231 cells○ Masayo HIRAO1, Shuso TAKEDA1, 2, Narumi SUGIHARA2, Masufumi TAKIGUCHI1, Masahiro OHARA3

1Faculty of Pharmaceutical Sciences, Hiroshima International University (HIU), 2Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, 3Department of Breast Surgery, JA Hiroshima General Hospital

P-203 Phenotypic characterization of targeted knockdown of Cyclin-dependent kinases in the intestinal epithelial cells○ Satoko Hashida NONAKA1, Masanori HIZUE1, Shuyan LU2, Tae SUNG2, Wenyue HU2, Brad HIRAKAWA2, Marina AMARO2, Bart JESSEN2

1Drug Safety Research & Development, Pfizer R&D Japan, 2Worldwide Research and Development, Pfizer Inc., La Jolla, CA

P-204 Identificationofsulfotransferaseisoformsinvolvedinthesulfationofthe reduced form of vitamin K3

○ Takahito NISHIYAMA, Mayu KIKUCHI, Mizuki TSUBOI, Yuuhei YOSHIDA, Tomokazu OHNUMA, Kenichiro OGURA, Akira HIRATSUKA

Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

P-205 Possible therapeutic agents for diphenylarsinic acid-induced aberrant activation of rat cerebellar astrocytes: heavy metal ion chelating agents○ Takayuki NEGISHI, Shoto SASAKI, Shuya WAKASUGI, Ayumi TAKAGI, Tomoka SHIBATA, Takamasa TSUZUKI, Kazunori YUKAWA

Department of Physiology, Faculty of Pharmacy, Meijo University

Cellular responseP-206 Melanin mediated storage of molybdenum

○ Kazunori HASHIMOTO, Akira TAZAKI, Nobutaka OHGAMI, Masashi KATO Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine

Program

(e-P

oster)

Molecular toxicologyP-207 The binding mode of organotins to peroxisome proliferator activated

receptor(PPAR)inthecartilaginousfishLeucoraja erinacea○ Youhei HIROMORI1, Youichirou ISHI2, Daisuke MATSUMARU2, Akiko IDO2, Hisamitsu NAGASE2, 3, L. Filipe C. CASTRO4, Tsuyoshi NAKANISHI2

1Fac. of Pharm. Sci., SUMS, 2Gifu Pharm. Univ., 3School of Health Sci., Gifu Univ. of Med. Sci., 4CIMAR., Porto Univ.

P-208 Superoxide dismutase 1 attenuates reactive quinoneimine formation from mefenamic acid in the human liver○ Tatsuki FUKAMI1, 2, Takuo OGISO1, Zhongzhe CHENG1, Keigo KONISHI1, Masataka NAKANO1, 2, Miki NAKAJIMA1, 2

1Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, 2WPI Nano Life Science Institute, Kanazawa University

P-209 Identificationofhumanacyl-CoAsynthetaseisoformcatalyzingCoAconjugation for propionic acid-class NSAIDs and evaluation of protein binding abilities of conjugate metabolitesMiki NAKAJIMA1, 2, Hiroki HASHIZUME1, Kanji MISHIMA1, Hiroshi ARAKAWA1, Masataka NAKANO1, 2, ○ Tatsuki FUKAMI1, 2

1Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, 2WPI Nano Life Science Institute, Kanazawa University

Gene regulationP-210 Roleofinflammatorycytokinesintheregulationofhepaticcytochrome

P450 expressions after cecal ligation and puncture-induced sepsis○ Takashi ASHINO1, Yuki NAKAMURA1, Hirokazu OHTAKI2, Yoichiro IWAKURA3, Satoshi NUMAZAWA1

1Division of Toxicology, Showa University School of Pharmacy, 2Department of Anatomy, Showa University School of Medicine, 3Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science

P-211 The regulation mechanism of pharmacokinetic factors by androgen receptor in the liver○ Yuichiro KANNO1, Nao SAITO1, Masakuni DEGAWA2, Kiyomitsu NEMOTO1

1Faculty of Pharmaceutical Sciences, Toho University., 2School of Pharmaceutical Sciences, University of Shizuoka

EpigeneticsP-212※ Gene expression changes of epigenetic-related genes and

spermatogenesis-related gene in the testes of F1 male mice gestationally exposed to arsenic○ Takehiro SUZUKI, Keiko NOHARA

Center for Health and Environmental Risk Research, National Institute for Environmental Studies

P-213 CpGsite-specificregulationinmousemetallothionein-1geneexpressionShoko OGUSHI, ○ Tomoki KIMURA

Faculty of Science and Engineering, Setsunan University

Pro

gram

(e

-Pos

ter)

OmicsP-214 Identificationofmetabolicbiomarkersinratplasmaforpredictionof

hepatotoxicity localization○ Akira HORINOUCHI1, 3, Atsushi ONO2, Yoshinobu IGARASHI3, Noriyuki NAKATSU3, Yuki YAMAGATA3, Hiroshi YAMADA3

1Spera Pharma, Inc., 2Faculty of Pharmaceutical Sciences, Okayama University, 3National Institutes of Biomedical Innovation, Health and Nutrition

P-215 Development of transcriptomic maps of preclinical species for assessment of target expression and distribution○ Tetsuki KATO1, Matthew MARTIN2, Dennis J PELLETIER2, Mark M GOSINK2, Petra H KOZA-TAYLOR2, Kim P KOWSZ2, Ingrid D PARDO2, William MOUNTS2, Jon C COOK2, Nagappan MATHIALAGAN2

1Drug Safety R&D, Pfizer R&D Japan, 2Pfizer Inc

P-216 An analytical framework using multilayer mass spectral similarity network to detect unknown compounds for toxicological analysis○ Eisuke HAYAKAWA1, Hiroshi WATANABE1, Kazunari KONDO2

1Okinawa Institute of Science and Technology Graduate University , 2National Institute of Health Sciences

BiomarkersP-217 Association between telomere length in human umbilical cord tissue

and serum polychlorinated biphenyl (PCB) concentration○ Tomoko TAKAHASHI1, Hiromi TANABE1, Akifumi EGUCHI1, Masahiro WATANABE1, Kenichi SAKURAI1, Chisato MORI1, 2

1Center for Preventive Medical Sciences, Chiba University, 2Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University

P-218※ An in vitro coculture system of human PBMCs with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury○ Shingo ODA1, Yuka UCHIDA1, Michael D. ALEO2, Petra H. KOZA-TAYLOR2, Masanori HIZUE3, Lisa D. MARROQUIN2, Jessica WHRITENOUR2, Eri UCHIDA3, Tsuyoshi YOKOI1

1Department of Drug Safety Sciences, Nagoya University Graduate School of Medicine, 2Drug Safety Research and Development, Pfizer Inc, Groton, CT, 3Drug Safety Research and Development, Pfizer Inc, Tokyo, Japan

P-219※ Investigation of pathophysiological roles of miR-218a-5p in cholestatic liver injury in ratsYuka HIRABUKI, Shingo ODA, Taiki TAKEUCHI, Takumi KAGAWA, ○ Tsuyoshi YOKOI

Department of Drug Safety Sciences, Nagoya University Graduate School of Medicine

P-220 Detection of renal tubular damage by monitoring urinary Liver-type Fatty Acid-Binding Protein (L-FABP) and novel nephrotoxicity biomarkers in adenine-induced Chronic Kidney Disease (CKD) model in rats○ Yoshiyuki SUZUKI1, 3, Atsuko ICHIKAWA1, Miyuki TAKAO1, Takayuki KUBOTA1, Genta IKEDA1, Kumiko KITTA1, Hiroyuki KOMATSU1, Takeshi SUGAYA2, Yasuki AKIE1, Takahiko MITSUI3, Masayuki TAKEDA3

1CMIC Pharma Science Co., Ltd., 2CMIC HOLDINGS Co., Ltd., 3University of Yamanashi, Faculty of Medicine, Department of Urology

Program

(e-P

oster)

Toxicity-testing methodsP-221※ Development of culture conditions for repeated dose toxicity test and

cholestasis toxicity testShinichiro HORIUCHI, Yukie KURODA, Ryuuya FUJII, Su-Ryang KIM, ○ Seiichi ISHIDA


P-222 ApplicationofrapidiPSCdifferentiationtoneurotoxicityassays○ Rie YAMOTO1, Tetsuya TANAKA2, Toshihiko HOSOYA1

1Drug Discovery Business Department, Healthcare Business Group, RICOH COMPANY, Ltd., 2Elixirgen Scientific, Inc.

P-223 Transportable human neuron plates○ Shinnosuke KOSHIZUKA, Tomoaki NAKAYAMA, Tatsuya SAMESHIMA, Tomofumi KITAZAWA, Momoko SHIONOIRI, Tomoyuki ARATANI, Toshihiko HOSOYA

Drug Discovery Business Department, Healthcare Business Group, RICOH COMPANY, Ltd.

P-224 Comparison of acute inhalation toxicity of sulfuric acid between intratracheal instillation and whole-body inhalation○ Kazuya TAKEUCHI1, Yusuke KURODA1, Takamasa NUMANO2, Masayuki KIMURA1, Seigo HAYASHI1, Satoshi FURUKAWA1

1Nissan Chemical Corporation, 2DIMS Institute of Medical Science, Inc.

P-225 Effectsofilluminanceandobservationclockhouronmioticresponseinrats○ Shintaro WADA, Tatsunobu MATSUI, Yuki NISHIKAWA, Shizuka KONISHI, Taeko KUROSAKA, Makoto UEDA, Keiichiro SATO, Yasuhiro YAMASHITA

Pharmacokinetics and Safety Assessment Dept., Discovery Research Labs., Nippon Shinyaku Co., Ltd.

P-226 GelatinfiberscaffoldisastrongtoolforevaluationofdrugresponseiniPSC derived cardiomyocytes○ Toshiki SAOTOME1, 2, Atsushi BABA1, Naoki SHIMADA2, Toshiaki ENDO3, Yuji IKEGAYA1, Kohei SAWADA1

1Grad. Sch. Pharmaceut. Sci., Univ. Tokyo, 2Research & Development Center, The Japan Wool Textile Co., Ltd., 3Life Innovation Business HQ, Yokogawa Electric Corp.

P-227 Development of an assay for drug-induced steatosis using fresh human hepatocytes(PXB-cells®)○ Mikaru YAMAO1, Mutsumi INAMATSU1, Keishi KISOH1, Yuko OGAWA1, Chihiro YAMASAKI1, Yuji ISHIDA1, 2, Chise TATENO1, 2

1 PhoenixBio Co., Ltd., 2Research Center for Hepatology and Gastroenterology, Hiroshima University

P-228 Examinationoffixingmethodforvaginalsmearspecimeninrodent○ Tadashi ITOH, Tetsuya YAMADA, Shinsuke SUZUKI, Takaomi SOGA, Kota SUGIMOTO, Junko SUZUKI, Makoto WATANABE, Yasuaki ISODA, Katsumi ENDO, Yoji MIWA, Takahiko NAGASE

Nihon Bioresearch Inc.

Pro

gram

(e

-Pos

ter)

P-229 Effectsofmicrosamplingontoxicokineticparametersincomparisonto conventional method, and investigation of alternate blood sampling route of microsampling on the anemic conditions in rats○ Fumika AKIZAWA1, Satoshi KONDO1, Yuya HIDOH2, Hiraku HAGITA2, Noriyuki KOYAMA2, Yuki INOUE1

1Otsuka Pharmaceutical Co., Ltd. Tokushima Research Institute, Nonclinical Research Center, Department of Drug Safety Research, 2Otsuka Pharmaceutical Co., Ltd. Tokushima Research Institute, Nonclinical Research Center, Department of Drug Metabolism and Pharmacokinetics

P-230 Effectofbloodmicrosamplingmethodonevaluationofanon-clinicalsafety study in rats –Oral gavage administration of phenacetin for 4 weeks–○ Harumi KITAURA, Hitoshi KANDORI, Kenta DANBAYASHI, Hirohiko OHTSUKA

Axcelead Drug Discovery Partners, Inc.

P-231 From hERG-centric to multiple ion channel current assessment -Development of high throughput multiple ion channel screening-○ Masafumi DOI, Tomoko SASAKI, Masako SAKAI

Discovery Pharmacokinetics Research Group, Pharmaceutical & ADMET Research Department, DAIICHI SANKYO RD NOVARE CO., LTD.

P-232※ Potential issues of learning and memory (LM) test methods in juvenile rat toxicity studies (JAS) for pediatric drug development○ Hiroshi MINESHIMA1, 2, Ryuichi KATAGIRI1, 3, Terutaka KODAMA1, 4, Toshihisa KODAMA1, 5, Takashi KOTERA1, 6, Mutsumi SUZUKI1, 7, Kazuko SUGIMOTO1, 8, Kiyoshi MATSUMOTO1, 9, Toshinobu YAMAMOTO1, 10, Masakatsu YAMAMOTO1, 11

1Non-Clinical Evaluation Subcommittee, Drug Evaluation Committee, Japan Pharmaceutical Manufacturers Association, 2Drug Safety Research, Nonclinical Research Center, Otsuka Pharmaceutical Co., Ltd., 3Translational Research Division, Chugai Pharmaceutical Co., Ltd., 4Toxicology and Pharmacokinetics Research Development, Research Institute, EA Pharma Co., Ltd., 5Pre-Clinical Development, Clinical Platforms & Science, Japan Development, GlaxoSmithKline K.K., 6Pharmacokinetics and Safety Assessment Dept., Discovery Research Labs., Nippon Shinyaku Co., Ltd., 7Translational Research Unit, R&D Division, Kyowa Kirin Co., Ltd., 8 Preclinical, Japan Regulatory Affairs, Medicines Developmental Unit Japan, Eli Lilly Japan K.K., 9Drug Safety Research and Evaluation, Research, Takeda Pharmaceutical Company Limited, 10Safety Research Laboratories, Sohyaku Innovation Research Division, Mitsubishi Tanabe Pharma Corporation, 11Nonclinical Development, Regulatory Affairs, MSD K.K.

P-233 Effectofnose-onlyinhalationexposureonestrouscycleinfemalerats○ Takashi HIRASHIMA, Kiyoshi WAKO, Yukari SATO, Seiji OOTAKE

Kashima Safety Assessment Department A, Nonclinical Research Center, Drug Development Service Segment, LSI Medience Corporation

P-234 Toxicity evaluation by high-content analysis of 3D cultured primary human hepatocytes○ Toshimasa ITO, Kazuhiro FUJIMOTO, Ryo FUJINO, Masato KOBAYASHI, Miki FUJISHIMA, Tsutomu NEGAMA

Pharmaceutical Sciences Division, Business Management Unit, SEKISUI MEDICAL CO., LTD.

P-235※ Measurement of axonal conduction velocity in in vitro peripheral neurons using CMOS-MEASayuri TAKAHASHI1, Yuri KATO2, Aoi ODAWARA1, Naoki MATSUDA1, Tadayuki TAURA2, Yusuke OIKE2, ○ Ikuro SUZUKI1

1Tohoku Institute of Technology, 2Sony Semiconductor Solutions Corporation

Program

(e-P

oster)

Analytical methodP-236 Rapidandsimultaneousquantificationofestrogensutilizingahigh-

resolution mass spectrometer○ Yoshinori OKAMOTO, Yoko MORI, Akira AOKI, Hideto JINNO

Faculty of Pharmacy, Meijo University

ToxicokineticsP-237※ Questionnaire survey on the status of use and awareness of

microsampling in pharmaceutical companies and future issues○ Kazuhiro TANIYAMA, Kousuke IIJIMA, Sayaka ITO, Takashige OKAYAMA, Manabu NISHIZAWA, Masayo HASHIMOTO, Suguru HATANAKA, Kazuyoshi YOSHII, Seiji TANAKA, Shin-ichi MIURA

Non-Clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceutical Manufacturers Association

Toxicologic pathologyP-238 INHAND: International Harmonization of Nomenclature and Diagnostic

Criteria for Lesions - an update - 2020○ Shimmo HAYASHI1, CM KEENAN2, A BRADLEY3, DG GOODMAN4, Takanori HARADA5, R HERBERT6, Hijiri IWATA7, M JACOBSEN8, R KELLNER9, B MAHLER6, E MESECK10, T NOLTE11, S RITTINGHAUSEN9, J VAHLE12, Katsuhiko YOSHIZAWA13

1Tokyo University of Agriculture and Technology, 2CM Keenan ToxPath Consulting, 3Charles River, 4Independent Consultant, 5The Institute of Environmental Toxicology , 6NIEHS, 7LunaPath LLC, 8Astra Zeneca, 9Fraunhofer ITEM, 10Novartis, 11Boehringer Ingelheim, 12Eli Lilly, 13Mukogawa Women University

Alternatives to mammalian modelsP-240 Investigation of analytical method focusing on a multivariate analysis

for a seizure risk assessment using in vitro MEA systems○ Ai OKAMURA1, Takayoshi MATSUBARA2, Remi YOKOI3, Kenichi KINOSHITA1, Takafumi SHIRAKAWA1, Ikuro SUZUKI3

1Drug Safety Research Lab, Drug Discovery Research, Astellas Pharma Inc., 2PerkinElmer Japan Co., Ltd., 3Department of Electronics, Tohoku Institute of Technology

P-241 Human iPS cell-based signaling reporter system for prediction of chemical teratogenicity○ Seiya KANNO1, Yusuke OKUBO2, Satoshi KITAJIMA2, Junji FUKUDA1

1Chemistry and Life Science, Faculty of Engineering, Yokohama National University, 2National Institute of Health Sciences

P-242※ Sigesbeckia Orientalis extract ameliorates diabetic nephropathy○ Hsiu Chu CHOU1, Chung Ming CHEN2, Tsui Ling KO3, Jer Yiing HOUNG4, Shu Hui JUAN5

1Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC., 2Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC., 3School of Medicine, I-Shou University, Kaohsiung, Taiwan, ROC., 4Department of Nutrition, Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, Taiwan, ROC., 5Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC.

Pro

gram

(e

-Pos

ter)

Animal modelP-243 Usefulness of anti-tumor evaluation model combining rasH2 gene

modifiedmousewithtwo-stagecarcinogenesismodel○ Teruaki HAGIWARA, Hiroto MIYATA, Yuuko DOI, Mayuko SUGURO, Norio IMAI, Yukinori MERA

DIMS Institute of Medical Science,Inc.

P-244 Pharmacokinetics/dynamics analysis of anticoagulant rodenticides with Egyptian fruit bats (Rousettus aegyptiacus)○ Kazuki TAKEDA1, Kosuke MANAGO2, Shouta M.M. NAKAYAMA2, Yusuke K. KAWAI3, Yoshinori IKENAKA2, 4, Mayumi ISHIZUKA2

1Institute of Innovative Research, Tokyo Institute of Technology, 2Graduate School of Veterinary Medicine, Hokkaido University, 3Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, 4Water Research Group, North-West University

Hypersensitive subjectsP-245 Sustainable approach to identify hazardous chemicals in the Oil and

Gas company○ Masao FUKUMURA, Salmaan Hussain INAYAT HUSSAIN

Product Stewardship & Toxicology, GHSSE, PETRONAS

Risk assessment and communicationP-246 InfluenceofanewEUGuidelineonEnvironmentalRiskAssessmentof

Pharmaceuticals in Japan○ Masamichi KAMINISHI1, 2, Sayaka ODAGIRI1, Daphne F. DE ROODE3, Hiroyuki MINAMI1

1Charles River Laboratories Japan, Inc., 2Showa University School of Medicine, 3Charles River Laboratories Den Bosch BV

P-247 Availability of a risk-based approach in process-based QA inspection in GLP studies○ Hayao OKAMURA1, 2, Takashi IKEDA1, 3, Sachiyo OZAWA1, 4, Naomi MATSUTANI1, 5, Ayami FUKUDA1, 6, Toshiaki NAMBA1, 7, Hiroyuki YAMANE1, 8, Isao WATANABE1, 9, Masuhiro TSUDA1, 10, Satoshi FUTAKAWA1, 11, Shinichi SUZUMURA1, 12

1JSQA GLP Division, Study Group 1, Subgroup 1, Team D, 2Kaken Pharmaceutical Co.,LTD., 3ASKA Pharmaceutical Co.,Ltd., 4Biosafety Research Center Inc., 5EA Pharma Co.,Ltd., 6Eisai Co.,Ltd., 7Ono Pharmaceutical Co.,Ltd., 8Chemicals Evaluation and Research Institue, Japan, 9Kowa Company, Ltd., 10TAIHO Pharmaceutical Co.,Ltd., 11RIBOMIC Inc., 12Maruho Co.,Ltd.

P-248 Gaps for GLP data management in Japan to data integrity guidance○ Yoshito OKABAYASHI1, Naofumi HAGIWARA2, Shigeru JOHKI3, Asami TAKAYAMA4, Kinue TAKEDA4, Fumi CHO4, Hidemitsu MATSUNAGA5, Ryo OHTA6, Fuminori KONDO7, Rie OHNO8, Yasunaga KAWASHIMA9, Misae ITO10, Yoko HIRAYAMA11, Takuya NAKAMA12

1Shionogi & Co., Ltd., 2Asahi Kasei Pharma Corporation, 3Astellas Pharma Inc., 4LSI Medience Corporation, 5Otsuka Pharmaceutical Factory, Inc., 6Food and Drug Safety Center, 7Sumitomo Chemical Co., Ltd., 8Taisho Pharmaceutical Co., Ltd., 9Takeda Pharmaceutical Co., Ltd., 10Chugai Pharmaceutical Co., Ltd., 11NIPPON SHINYAKU CO., LTD, 12FUJIFILM Toyama Chemical Co., Ltd.

Program

(e-P

oster)

P-249 Development to toxicity assessment method of nanomaterials using multivariate analysis○ Akiko OHNO1, Masatoshi WATANABE2, Akihiko HIROSE1

1Division of Risk Assessment, National Institute of Health Sciences, 2Graduate School of Medicine, Mie University

P-250 Estimation of human medicine concentrations in the rivers using watershed model○ Tadashi UCHINO, Norihiro KOBAYASHI, Yoshiaki IKARASHI

Division of Environmental Chemistry, National Institute of Health Sciences

P-251 Human health and environmental risk assessment of chemicals in daily use -Safety assessment of alkyl amidopropyl betaine in consideration of using consumer product-○ Kenta ITE, Kiyoko NARUSE, Yuichi ITO, Mitsuo HANADA, Masayuki YAMENE, Osamu MORITA

Kao Corporation

P-252 Application of read-across in screening assessment of general chemicals : Collection and selection of candidates for analogue substances○ Yoshiro YOSHIZAKI, Kazuo USHIDA, Kaoru KAI, Mariko MATSUMOTO, Kaoru INOUE, Takashi YAMADA, Akihiko HIROSE

Division of Risk Assessment, National Institute of Health Science

P-253 Application of read-across in screening assessment of general chemicals : A case of Nonan-1-ol (C9H20O)○ Kazuo USHIDA, Kaoru KAI, Yoshiro YOSHIZAKI, Mariko MATSUMOTO, Kaoru INOUE, Takashi YAMADA, Akihiko HIROSE

Division of Risk Assessment, National Institute of Health Science

P-254 Proposal for concentrations of drinking-water contaminants to protect human health under transient emergency situations○ Mariko MATSUMOTO, Yoshiyuki SHIGETA, Tomoko KAWAMURA, Kaoru INOUE, Takashi YAMADA, Akihiko HIROSE

Division of Risk Assessment, Center for Biological Safety and Research, National Institute of Health Sciences

P-255 Mutagenicity assessment of inorganic substances permitted by thepositivelistforfoodpackaging;Focusingnanosizedinorganicsubstances○ Takako ISO1, Mariko MATSUMOTO1, Hiroshi SUZUKI1, Kei-ichi SUGIYAMA2, Masamitsu HONMA2, Akihiko HIROSE1

1Division of Risk Assessment, National Institute of Health Sciences, 2Division of Genetics and Mutagenesis, National Institute of Health Sciences

Information technology, AI, and big dataP-256 The future of GLP brought about by new IT technologies

○ Ryo OKUMURA Japan Society of Quality Assurance (JSQA)

Pro

gram

(e

-Pos

ter)

P-257 Introduction to the Community for Non-clinical Data Utilization and Visualization(CNUV)andSpotfireSENDViewer(SSV)○ Misa MATSUMURA1, 2, Junji TAKAGI1, 3, Masanori KUZUMOTO1, 2, Naoki TORITSUKA1, 4, Naotaka OISHI1, 5, Tomoaki TOCHITANI1, 6, Tomoya ONOZATO1, 7, Kana NOZATO1, 3, Yuko TANAKA1, 8, Koichiro HORI1, 8

1The Community for Non-clinical Data Utilization and Visualization (CNUV) team, 2SHIONOGI & CO., LTD., 3CAC Croit Corporation, 4Eisai Co., Ltd., 5PerkinElmer Japan Co., Ltd., 6Sumitomo Dainippon Pharma Co., Ltd., 7KISSEI PHARMACEUTICAL CO., LTD., 8JAPAN TOBACCO INC.

P-258※ Quality assurance of SEND data: Preparation of correspondence table betweentheitemsinthefinalreportandvariablesinSENDdata○ Takashi TANAHARU, Mikio NAKAJIMA, Gen SATO, Masakatsu YAMAMOTO, Yuki INOUE, Keita KOBAYASHI, Akinori KIYA, Mayumi WATANABE, Izumi MATSUMOTO, Takafumi YAMAGUCHI, Hitomi HAYASHI, Yoshihisa NAKANO, Keiko MOTOYAMA, Mutsumi SUZUKI

SEND Task Force, Non-clinical Evaluation Expert Committee, Japan Pharmaceuticals Manufacturers Association

P-259※ QualitativeanalysisofactualSENDdatasets(2ndreport); Survey results on data domains○ Mayumi WATANABE, Izumi MATSUMOTO, Gen SATO, Mikio NAKAJIMA, Masakatsu YAMAMOTO, Yuki INOUE, Keita KOBAYASHI, Takashi TANAHARU, Akinori KIYA, Takafumi YAMAGUCHI, Hitomi HAYASHI, Yoshihisa NAKANO, Keiko MOTOYAMA, Mutsumi SUZUKI

SEND Task Force, Non-clinical Evaluation Expert Committee, Japan Pharmaceuticals Manufacturers Association

P-260 Points to be considered toward future SEND implementation of genotoxicity study data○ Naoki TORITSUKA1, 2, Konomi IINO1, 3, Norio IMAI1, 4, Koshirou KATOKU1, 5, Yoshifumi KANEKO1, 6, Terukazu KITAHARA1, 7, Yuta SAKAKIBARA1, 8, Gen SATO1, 2, Sayaka TAKAMI1, 9, Hiroyuki NITTA1, 10, Koichi HASHIGUCHI1, 11, Taishi MIYASHITA1, 12

1CDISC Japan User Group (CJUG) SEND team, 2Eisai Co., Ltd., 3Ina Research Inc., 4DIMS Institute of Medical Science Inc., 5LSI Medience Corporation, 6KYORIN Pharmaceutical Co., Ltd., 7Instem Japan K.K., 8Kyowa Kirin Co., Ltd., 9Nihon Bioresearch Inc., 10Ono Pharmaceutical Co., Ltd., 11Shin Nippon Biomedical Laboratories, Ltd., 12KAKEN Pharmaceutical Co., LTD.

P-261 Encouragement for involvement of toxicologists in improving the quality of SEND data and how to use the CJUG SEND check list○ Dai YAMAMOTO1, 2, Yoshifumi KANEKO1, 3, Junya MORITA1, 4, Koji AKIBA1, 5, Takashi UOTA1, 6, Terukazu KITAHARA1, 7, Koichi SATO1, 8, Koichi SUWA1, 9, Matsuki TSUCHIYA1, 10, Atsushi HAMADA1, 11, Yoshinori FUJIMURA10, Shinichi HORIKAWA1, 12, Yasuhiro MASUZAKI1, 11, Misa MATSUMURA1, 13, Takayuki YASUDA1, 6, Yuta SAKAKIBARA1, 14

1CDISC Japan User Group (CJUG) SEND team, 2LSI Medience Corporation, 3KYORIN Pharmaceutical Co., Ltd., 4Taisho Pharmaceutical, Co., Ltd., 5Mitsui E&S Systems Research Inc., 6CAC Croit Corporation, 7Instem Japan K.K., 8Takumi Information Technology Inc., 9BoZo Research Center Inc., 10FUJITSU LIMITED, 11Japan Tobacco Inc., 12Ina Research Inc., 13SHIONOGI & CO., LTD., 14Kyowa Kirin Co., Ltd.

Program

(e-P

oster)

P-262 AnewperspectiveonefficientSENDdatacreationusingdefine-XMLfile○ Akito SAKAMOTO1, 2, Yoshifumi KANEKO1, 3, Yuta SAKAKIBARA1, 4, Koichi SATO1, 5, Atsushi HAMADA1, 6, Yasuhiro MASUZAKI1, 6, Taishi MIYASHITA1, 7, Shizuka MIYATA1, 8, Akihito YAMASHITA1, 9, Takayuki YASUDA1, 10

1CDISC Japan User Group (CJUG) SEND team, 2LSI Medience Corporation, 3KYORIN Pharmaceutical Co., Ltd., 4Kyowa Kirin Co., Ltd., 5Takumi Information Technology Inc., 6Japan Tobacco Inc., 7KAKEN PHARMACEUTICAL CO., LTD., 8FUJITSU LIMITED, 9Sumitomo Dainippon Pharma Co., Ltd., 10CAC Croit Corporation

P-263 Challenge and case examples (based on the feedback from FDA SENDIG v3.1 FFU Pilot) in creation of SENDIG v3.1 datasets for safety pharmacology studies○ Yasue SAKAGUCHI1, Shin-ichi HORIKAWA1, Konomi IINO1, Tadashi USHIMARU1, Hirofumi HATAKEYAMA1, Shin-ichi SATO1, Takayuki ANZAI2

1Ina Research Inc., 2Showa University School of Medicine

P-264 Suggestions in visualizing multiple studies using SEND○ Takashi UOTA1, 2, Yoshifumi KANEKO1, 3, Terukazu KITAHARA1, 4, Yuta SAKAKIBARA1, 5, Gen SATO1, 6, Koichi SATO1, 7, Takashi TANAHARU1, 8, Atsushi HAMADA1, 9, Yasuhiro MASUZAKI1, 9

1CDISC Japan User Group (CJUG) SEND team, 2CAC Croit Corporation, 3KYORIN Pharmaceutical Co., Ltd, 4Instem Japan, 5Kyowa Kirin Co., Ltd., 6Eisai Co., Ltd., 7Takumi Information Technology Inc., 8Bristol-Myers Squibb K.K., 9Japan Tobacco Inc.

P-265 Discussion of points to consider in creating nSDRG of SEND datasets○ Hitoshi WATANABE1, 2, Miho IMAWAKA1, 3, Koshirou KATOKU1, 4, Yoshifumi KANEKO1, 5, Akinori KIYA1, 6, Yuta SAKAKIBARA1, 7, Sayaka TAKAMI1, 8, Koichi HASHIGUCHI1, 9, Atsushi HAMADA1, 10, Tamio FUKUSHIMA1, 6, Izumi MATSUMOTO1, 2

1CDISC Japan User Group (CJUG) SEND team, nSDRG subteam, 2Sumitomo Dainippon Pharma Co., Ltd., 3Axcelead Drug Discovery Partners, Inc., 4LSI Medience Corporation, 5KYORIN Pharmaceutical Co., Ltd., 6Shionogi Pharma Co., Ltd., 7Kyowa Kirin Co., Ltd., 8Nihon Bioresearch Inc., 9SHIN NIPPON BIOMEDICAL LABORATORIES, LTD., 10Japan Tobacco Inc.

P-266 Translational drug safety with chemotargets CLARITY○ Atsushi MIDORIKAWA1, Ricard Garcia SERNA2, Montserrat CASES2, Joaquim OLIVéS2, Nikita REMEZ2, Elisabet Gregori PUIGJANé2, Jordi MESTRES2

1World Fusion Co., Ltd., 2Chemotargets, S.L.

P-267 A novel deep learning-based prediction modeling approach using molecular image in the activation of progesterone receptor○ Yasunari MATSUZAKA, Shunichi SASAKI, Yoshihiro UESAWA

Department of Medical Molecular Informatics, Meiji Pharmaceutical University

AOP (adverse outcome pathway)P-268 Accessing Marketed Drug Information to Inform PreClinical Safety

○ Takahiro OHYAMA, Pooja JAIN, Thomas VARGUES, Misato SAITO, Olivier BARBERAN

Elsevier Japan

Pro

gram

(e

-Pos

ter)

OrganoidP-269 Investigation for in vitro gastrointestinal toxicity evaluation of

anticancer drugs using intestinal organoids culture system○ Daichi NAGAI, Kimiko FUCHIGAMI, Yuuji OKUDA, Eiji ICHIMURA

Toxicology Team, Pharmaceutical Research Laboratories, Nippon Kayaku Co., Ltd.

Program

(e-P

oster)

day 1 am (june 29 (mon)) program › document › program_en.pdf · s4-5 interaction and cross-talk...

Documents