decei'iber 1970 ii - nasa · decei'iber 1970. part ii . ... 4. blood pressure response to...

FINAL REPORT DECEI'IBER 1970

PART II

A Study of the Role of Extravascular Dehydration in the Production of Cardiovascular Deconditioning by Simulated Weightlessness (Bedrest)

NASA CONTRACT T-68099(G)

Principal Investigator - Kenneth 11. Hyatt, M.D.

Co-Investigators - William 14. Smith, M.D. John 11. Vogel, M.D. Robert TP. Sullivan, M.D. William R. Vetrer, M.D. Burton E. Calder, M.D. Byron J. Bohnn, M.D. Victor 14 lHaughton, M.D.

Reproduced by -

NATIONAL TECHNICAL INFORMATION SERVICE

U S Department of Commerce

Springfield VA 22151

Medical Department U.S. Public Health Service Hospital

San Francisco, California

7373 2(Th (PA E~ y (COD)

(NASA CR OR TMX OR AD NUMBER) (CATEG RY)

https://ntrs.nasa.gov/search.jsp?R=19710007228 2018-07-08T17:08:04+00:00Z

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CONTENTS - PART II

1AISLES

i. General Data

2. Heart Rate Response to 700 Tilt and Recovery

3, Response to 700 Tilt - Group Means for Heart Rate

4. Blood Pressure Response to 700 Tilt and Recovery'

5. Pulse Pressure Response to 70G Tilt and Recovery

Tilt Group Means for Pulse Pressure6. Response to 700

7. Litb Volume Increase During 700 Tilt and Recovery

8. Heart Rate Response to Exercise and Recovery

9. Response to Exercise - Group Means for Heart Rate

- Heart Rat10. Response to Exercise Paired "t" Test Analysis

Response to Exercise

- Heart Rate Recovery11. Response to Exercise Group Means

Following 100 Watt Exercise

12. Respons& to Exercise Paired "t" Test Analysis.

Oxygen Consumption13, Response to Exercise

14. Response to Exercise - Group Means for Oxygen Consumption

15. Response to Exercise Minute Ventilation

- Group Means for Minute Ventilation16. Response to Exercise

- Pre-Bedre17. Response to Exercise Paired "t" Test Analysis

vs. Recovery

18. Response to Exercise - Ventilatory Equivalent

19. Response to Exercise - Group Means for Ventilatory Equivaloit

20. Derived Maximal Oxygen Uptake (ml/min)

21. Derived Maximal Oxygen Uptake (ml/kg x min)

22. Pulmonary Function

23, Urine Chemistry Summary

24. Urine Nitrogen Summary

25. Average Daily Sodium Excretion By Week of Study

26 Average Daily Potassium Excretion By Week of Study

27. Average Daily Chloride Excretion By Week of Study

28. Average Daily Calcium Excretion By Week of Study

29. Average Daily Nitrogen Excretion By Week of Study

30. Paired "t" Test Analysis, Urine Electrolyte and Nitrogen Excretion

31. Diet Analysis

32. Average Daily Stool Calcium By Week of Study

33. Average Daily Calcium Balance By Week of Study

34. Aldosterone Excretion Summary

35. AverageDaily Aldosterone Excretion By Week of Study

36. Aldosterone Excretion Paired "t" Test Analysis

37. Fluid Balance Summary

38. Average Daily Fluid Balance By Week of Study

39. Paired "t" Test Analysis - Flutd Balance

40. Body Fluid Compartments

41. Body Fluid Compartments and Weight - Group Means

42.. Body Fluid Compartments and Weight - Paired "t" Test Analysis

43. Response to 700 Tilt and Plasma Volume Alteration -Individual Results

44. Response to 700 Tilt and Plasma Volume Alteration - Group Means and Paired "t" Test Analysis

45. Alterations in Serum Proteins During 700 Tilt

3

46. Serum Chemistries

47. Urine Osmolality

48. Osmotic and Free Water Clearance

49. Bematology Data

FIGURES

1. Alterations in Fluid Balance, Sodium and Aldosterone Excretion

2, Alterations in Body Fluid Compartments and Weight

4

TA1BLI

GENERAL DATA

Subject Age ' Height.

(inches) Weight (kg) Smoking (per day)

Cl RI R8 RI5

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21

23 29 27 24 25 25 21 24 29 27 23 22 24 23 26 22 29 24 25 26 22

67 69 70 72 70 67.5 69 70.5 69 69.5 68 67.5 70 72 70 70 65.5 69.5 68 67.5 67

64.480 64.880 64.995 72.480 58.330 62.390 60.255. 82.560 68.700 85.420 68.300 64.176 69.288 70.784 82.250 66.640 54.850 70.550 64.960 79,260 66.520

64.880 64.350 66.165 72.110 58.130 62.130 60.415 82.470 67.970 85.460 67.965 64.556 69.108 70.729 81.620 65.940 55.250 70.150 64.260 78.980 65.860

64.540 63.395 67.065 70.710 57.270 60.590 60.490 82.860 67.300 86.370 67.860 64.821 68.423 70.074 80.500 65.320 55.420 68.740 64.630 78.240 66.960

64.445 63.7A0 67.980 71.680 57.250 60.570 60.640 83.100 66.840 86.870 67.755 64.971 69.018 69.894 80.150 64.470 55.420 69.250 64.720 78.350 67.020

65.520 64.530 67.825 71.380 57.420 60.550 60.680 82.860 66.240 86.870 67.550 64.916 68.993 69.379

64.420 55.520 69.950 64.550 77.950 67.350

Cigars 4-5 Cigars 5 Gigs. I pk. Cigs. 1 pk. Cigs. 1 pk, Cigs. 1 pk. Gigs. 2 pk. Gigs. 1 pk. Cigars .2-3 None Gigs. .5 pk. Gigs. .5 pk. Gigs. .5 pk. Gigs. 1 pk. Cigs. I pk. Rare Gigs. Ipk. Cigs. 1 pl.~ Gigs. 1 pk, Gigs. I pk. None

U 22 23 24

25 24 25

72 67 68

83.730 73.360 74.120

82.320 73.670 73.720

80.530 71.060 73.420

81.170 72.450 73.430

80.460 72.930 74.250

Gigs. Cigs. Cigs.

I pk. 1 pk. 1 pk.

TABLE 2

}EART RATE RESPONSE TO 700 TILT AND RECOVERY

Subject. Day of Study Terminal Time Tilt Time (min) Recovery Time (min)

Baseline 5 10 15 Terminal 1 5 10

C14 59 92 90 93 90 55 52 55 R 1 85 90 105 110 125 90 70 70

1 R 3 R 8

78 66

100 105

105 124

105 125

110 120

60 60

65 70

70 72

R15 68 90 90 100 90 55 60 55

014 55" 82 90 90 * 55 60

2R R i

3 62 60

95 100

100 110

100 100

100 96

60 60

62 58

60 58

R 8 58 86 90 95 100 55 54 58' R15 57 85 .90 92 100 60 58 62

C14 71 103 120 115 135 75 62 62

3 R 1 R 3

83 65

106 90

!137 103

143 103

148 105

100 68

95 60

87 62

R 8 RI5

60 76

85 100

80 112

100 100

105 116

65 85

70 70

60 66

014 53 70 100 80 80 45 50 50 R 1 11 75 90 100 90 70 65 70

4 R 3 78 85 80 85 85 70 70 75 R 8 73 90 95 95 95 60 60 50 RI5 62 75 75 75 75 55 50 55

TABLE2

1EART RATE RESPONSE TO 700 TILT AND RECOVERY

Subject Day of Study Terminal Time Tilt Time (min) Recovery Time (min) (min)


C14 59 85 87 100 95 62 62 56 R 1 13.5 64 87 95 - ..0 50 54 60

5R 3 59 82 87 90 93 62 60 56 R 8 75 90 95 105 100 65 60 70 RI5 14.5 64 100 106 - 50 70 60 60

C14 55 105 90 95 95 50 50 55 R I 13 66 106 110 112 50 58 60

5R 3 66 96 95 100 106 50 58 60 R 8 72 100 105 100 110 65 60 60 RI5 57 100 ,87 112 110 42 45 50

C14 51 75 60 60 45 40 55 55 R 1 53 80 80 100 75 50 50 55

7R 3 62 84 88 90 90 50 -47 52 RI5 51 80 80 80 75 50 50 55

C14 90 110 -20 125 125 100 95 90 R i 100 120 130 140 145 115 110 100

8 R 3. 90 115 10 125 120 90 90 90 R 8 83 100 102 105 110 86 80 78 RI 92 110 120 120 It0 90 90 85

-ci

TABLE 2

EART RATE RESPONSE TO 700 TILT AND RECOVERY

Subject Day of Study Terminal Time Tilt Time (min) Recovery Time (min) (min)


C14 72 85 85 85 80 80 60 65 R 1 83 100 100 100 100 90 80 80

9 R 3 71 80 80 78 75 70 60 68 R 8 72 85 85 80 85 70 70 65 R15 71 100 86 80 80 70 .65 60

C14 90. 100 105 110 120 100 85 85 R i 72 85 100 120 100 70 70 so

10 R 3 88 100 102 106 102 82 80 85 R 8 79 95 95 100 95 70 70 75 RI5 82 85 90 95 100 70 60 65

C14 64 82 92 90 95 50 60 62 R i 10.5 69 98 100 61 64 63

11 R 3 65 84 92 92 90 64 66 62 R 8 60 80 85 80 90 60 60 60 RI5 68 80 85 80 85 45 50 50

C14 68 90 108 99 94 68 60 57 R i 74 110 126 130 130 84 82 75

12 R 3 71 112 96 106 120 74 76 69 R 8 72 95 90 90 100 60 55 70 R15 73 85 100 95 115 60 60 60

TABLE 2

HEART RATE RESPONSE TO 700 TILT AND RECOVER)

Subject Day of Study Terminal Time (min)

Tilt Time (min) Recovery'Time (min)

Baseiine 5 10 15 Terminal 1 5 10

13

C14 R I R 3 R 8 RI5

61 71 80 73 70

90 108 95 90 90

108 115 85 90 90

104 120 100 80

100

106 120 105 85 90

58 68 75 60 55

64 80 70 60 50

66 75 70 70 50

C14 R i

53 65

70 105

85 10

100 130

90 135

45 55

54 60

58 75

14 R 3 R 8 RI5

63 63 68

90 100 90

80 95 90

110 95 105

135 115 110

60 50 45

50 55 50

60. 55 50

15R

C14

i R

64

60 66

69

78 75

68

75 72

70 78 72

70 86 78

58 64 64

68 60 55

64 64 68

R8

16

014 R I R 3 R 8 R15

58 60 65 55 57

75 90 85

100 80

70' 95 90 80 90

90 105 90 100 105

75 115 100 85

100

50 55-55 50 55

50 65 .55 50 50

-55-65 65 55

.55

TABLE 2

'JEART RATE RESPONSE TO 700 TILT AND RECOVERY

Subject Day of Study Terminal Time Tilt T-ime (min) Recovery Time (min) (min) I


C14 56. 67 70 64 76 56 63 56 R 1 8.5 52 81 83 42 45 50

17 R 3 56 72 82 78 85 58 54 59 R 8 55 69 69 70 71 49 49. 47 RI5 45 60 60 70 66 43 44 44

C14 68 83 78 77 89 55 52 56 R 1 69 92 111 101 117 68 69 65

18 R 3 .60, 70 102 80 91 51 50 55 R 8 53 79 77 85 80 44 45 43 R15 68 82 -98 .89 89 "46 43 48

C14 55 86 95 104 110 59 65 65 R 1' 63 100 110 115 120 60 80 80

19 R 3 58 80 82 85 105 50 55 55 52 50 60H,:R 8 68 95 100 95 105

R15 70 110 110 115 125 55 63 70

C14 59 90 100 90 102 62 65 60 R i 70 120 125 130 112 110 75 68

20 R 3 71 90 86 83 85 60 50 .50 R 8 68 100 90 90 95 80 65 65 R15 66 95 110 120 120 50 55 55

TABLE 2

HEART RATE RESPONSE TO 700 TILT AND RECOVERY

Subject'. Day of Study Terminal Time Tilt Time (min) Recovery Time (min) (min)

eline 5 10 15 Terminal 1 5 10

C14 56. 95 97 100 95 55 55 60 20 R I 53 85 85 95 95 55 50 50R 8 55 75 1-85 50 50 5580 00

RI5 53 80 80 85 80 50 50 50

014 68 92 92 105 100 60 70 65 R i 73 95 100 105 115 70 70 80R 8 75 90 95 105 105 70 .70 .70

RI5' 63 75 85 80 90 65 60 60

014 53 60 '60 60 55 50 50 50 R i 63 80 80 80 80 55 55 60

23 R 3 70 80 90 95 90 60 65 65. R 8- 60 .75 75 75 80 50 55 55 RI5 60 80 80 80 80 55 -55 '60

014 65 80 80 "75 85 55 55 -60 R 1 73 105 110 100 125 90 70 70

24 R 3 80 100 100 100 115 65 70 80 RI5 80 85 110 105 110 65 65 75

TABLE 3

RESPONSE TO 700 TILT GROUP MEANS FOR HEART RATE

Day.-of Supine - Tilt Time (min) Recovery Time (min' Study Rest

5 10 15 Terminal 1 5 10

C14 62 86 91 93 93 61 61 61

Ri 69 97 106 113 110 68 69 70

R 3 69 90 92 95 99 64. 62 64

R 8 67 90 90 93 97 61 60 62

RI5 -66 82 92 94 .96 58 56 58

12

TABLE 4 BLOOD PRESSURE RESPONSE TO 700 TILT AND RECOVERY

(mmHg5

Subject Day of Study Terminal-T-ime TiltTime'(min) Recovery Time (mini)

./Baseline 5 10 15 Terminal 1 5 10

C14 114/66 122/90 120/90 116/94 118/96 116/68 110/74 112/70 R i 118/78 130/100 130/98- 124/100 130/100 126/86 120/80 120/84

R 3 118/72 124/102 130/98 '126/100 134/108 120/70 124/84 124/80

R 8 112/70 114/76 112/84 114/88 110/88 118/78 112/72 114/80

RI5 4I14/64 116/90 120/94- 120/96" 120/100 124/78 118/74 120/72

C14 108/70 98/76 96/74 92/80 76/60 112/70 116/80 112/80

R i 106/72 108/80 110/90 96/88 106/90 110/80 108/84 104/80

2 R 3 106/68 104/90 11Q/84 110/90 96/80 116/80 110/78 108/72

R 8 100/62 94/70 102/76 98/74 94/82 106/70 102/70 96/68

RI5- 100/68 100/84 '102/80 104/80 110/86 112/74 100/70 104/60

c14 126/80 136/98 134/104 '110/100 §0/84 130/96 134/90 130/86

R i 120/88 142/100 140/100 130/96 114/90 130/100 130/90 130/88

3R 3 114/72 126/84 124/88 118/88 120/88 120/84 120/76 116/80

R 8 122/76 130/96 120/90 134/94 120/94 124/80 120/80 124/80

R15. 104/70 112/90 104/80 130/84 120/86 122/86 116/84 116/80

C14 98/68 100/87 104/80 110/78 110/86 96/68 100/62 100/62

R 1 11 108/70 116/94 110/84 74/70 102/64 112/80 112/76 4 R 3 102/66 116/76 122/82 120/80 122/86 110/80 104/70 106/72

R 8 106/64 114/90 112/80 114/90 110/80 108/60 108/65 106/70

RI5 104/64 114/88 114/80 120/80 118/86 104/70 104/72 112/72

TABLE 4 BLOOD PRESSURE RE-SPONSE TO 700 TILT AND RECOVERY

Subject Day of Study. "TerminalTime Tilt Time (min) Recovery Time (mih)'

.-Baseline 5 10 15 Terminal 1 5 10

C14 134/80 .140/100 128/96 130/100 134/106 134/90 138/88 132/80. .R 1 13.5 120/78 122/100 130/98 0 140/80 126/80 124/86

5R 3 126/74 128/96 134/100 144/100 138/100 134/88 130/80 124/80 R 8 120/90 128/108 136/98 120/102 130/110 132/84 .120/80 124/86 RIb 14.5 128/74 120/94 126/100 . 0 130/84 .120/84 118/76

014 92/56 90/60 98/68 90/70 100/72 100/58 98/60 92/58 R 1 13 94/64 98/76 100/74 72/60 100/62 90/58 98/58

6 R 3 104/60 106/80 102/78 100/78 104/76 106/66 -106/60 106/64 R 8 94/58 92/66 90/70 96/74 86/64 92/60 100/58 98/60 R15 98/56 94/70 94/70 84/64 70/62 82/58 92/56 92/68

c14 94/60 90/80 90/70 88/70 72/60 84/54 90/64 90/64 R I 100/64' 96/80 102/76 94/80 90/80 94/60 98/64 '.96/62

7 R 3 98/68 102/78 94/80 94/80 96/80 100/64 100/64 96/64 R 8 94/54 90/74, 94/72 90/74 86/72 94/60 94/60 96/60 R15 90/56 90/70 90/74 96/74 90/74 90/56 94/56 88/50

C14 126/62 138/94 126/92 126/96 130/102 124/88 132/90 130/92 *R 1 130/84 150196 146/98 144/100 142/100 126/90 122/84 122/84

8 R 3 130/78 134/76 144/82 140/86 138/90 132/78 124/76 122/72 R 8 120/70 118/90 126/80 128/80 124/88 120/78 -124/70 120/70 RI5 128/68 130/80 136/80 122/80 120/80 116/60 110/78 118/70

TABLE 4 BLOOD PRESSURERESPONSE TO 700 TILT AND RECOVERY

(mmHg)

Subject fDay of Study Terminal Time Tilt Time (min) Recovery Time (min).

' 5 10 15 Terminal, 5 10:Baseline

014 138/76 136/90 124/84 114/84 112/80 130/80 126/84 130/80 R i 116/70 130/88 112/82' 118/84 116/84 112/88 112/80 118/70

9R 3 114/80 106/82 110/82 104/78 104/82 106/70 108/72 104/62 R 8 120/74 108/90 102/92 110/98 112/94 106/72 108/80 100/78 RI5 --118/80 114/88 110/88 100/84 108/80 100/70 . 96/76 96/70

014 134/90 130/100 133/104 140/104 142/106 130/90 126/90 128/90 R 1 120/74 132/92 140/90 136/102 138/96 116/80 118/80 120/80

10 R 3 120/82 136/104 140/100 136/100 130/110 122/90 120/84 114/84.R 8 118/70 120/90 130/88 130/98 126/94 130/80 120/80 120/70 RI5 118/70 128/90 140/96 128/100 130/100 124/78 120/80 122/70

C14 110/60 104/80 104/74 104/74 102/74 110/60 104/58 1O8/70 R 1 10.5 110/50 . 110/80 76/60 70/64 90/60., 118/80 114/70

11 R 3 110/68 114/78 118/86 110/78 112/84 98/66 108/62 108/70 R 8 104/62 102/80 108/70 104/80 110/80 102/60 126/66 106/68 R15 104/58 104/74 104/78 106/78 108/70 110/60 102/66 --110/68

014 110/76 134/92 130/86 138/90 144/90 120/80 110/74 112/80 Ri 114/70 134/104 130/96 138/100 140/82 122/76 106/70 116/78

12 R 3 104/68 120/88 122/84 130/88 126/92 118/68 110/68 104/68 R 8 100/70 104/92 114/80 116/94 112/88 110/80 106/70 •108/64 R15 112/70 120/88 124/90 130/90 124/86 106/70 112/78 110/68

TABLE 4 BLOOD PRESSURE RESPONSE TO 700 TILT AND RECOVERY(mmHg)

Subject Day of Study'. Terminal Time Tilt Time (min) Recovery Tim& (min)

Baseline 5 10 15 Terminal 1 5 10.

'C14 ,98/58 106/60 92/60 94/68 96/60 112/70 100/62 '96/60 R 1 110/60 122/80 ' 120/84 114/74 110/78 120/78 114/74 '.116/80

13 R 3 110/48 116/78 122/74 128/78 120/70 114/50 100/50 98/60 R 8 104/60 108/68 104/80 ' 116/78 100/80- 104/60 110/64 106/60 R15 106/50 116/78 118/70 116/76 ' 112/78 108/58 102/58 100/60

C14 104/48 104/54 92/58' 104/62 92/70 120/56 110/50 '.110/60 R I 114/64 110/80 114.90 110/98 120/88 148/80 124/74 120/80

14 R 3 128/60 ' 112/78 112/78 116/80 120/80 124/62 112/60 .114/64 R 8 106/50 108/80 94/76 104/80 106/76 118/60 114/60 112/80' R15 90/58 90/72 90/70 98/86 118/80 100/64 104/6d 90/62

014 110/68 118/72 i04/70 104/70 100/68 104/60 104/66 96/64 R i 104/64 112/72 106/60' 106/70 120/72 112/60 -108/60 112/60

15 R 3 95/50, 106/72 110/70 128/76 112/72 100/58 104/60 94/60. R 8 92/58 106/60 106/70 108/80 112/76 96/60 -102/6d 92/60 R15

C14 104/60 92/60 104/60 104/60 94/60 112/70 110/60 112/70 R 1 110/76 102/78 108/96 104/76 116/84 112/76 108/74'106/74

16 R 3 -102/70 100/72 100/70 104/74 100/72 114/78' 116/74 11t/70 R 8 98/56 90/70 92/68 90/68 94/68 100/60 110/70 98/60 R15 90/68 90/70 100/64 84/68 92/70 102/70 98/7d,' 98/68

TABLE 4 BLOOD -PRESSURE RESPONSE TO 700

(mmng) TILT AND RECOVERY

Subject

17

18

19

20

' Day of Study

C14 Rt 1 R 3 R 8 Ri5

C14 R I R.3 R 8 R15

014 R I R 3 R 8 Ri5

014 R1 R 3 R 8 R15

Terminal Time

8.5'

.Baseline

110/68-120/80 .120/80 114/70 114/68

100/64 128/60 124/70 116/56 116/60

116/80 *.

104/62 94/58

104/60 104/66

138/92 120/70 114/70 118/60 118/68

/ Tilt Time (min)

5 10 15

102/80 104/80 120/84 132/95 134/88 126/96 126/90 i30/90 130/90 134/96 120/84 126/90. 130/82

100/80 98/80 112/76 130/100 122/104 134/84 124/84 140/86 120/90 124/90 116/76 120/96 114/90 120/76 112/84

116/92 120/90 118/94 117/84 124/90 130/78 110/80 110/80 110/80 100/76 96/84 110/78 118/70 110/70 90/78

142/98 130/90 136/96 120/94 130/80 120/88 126/74 110/76 124/74 110/84 122/84 120/86 120/82 120/78 114/82

Terminal

120/84 0

120/90 116/94 130/90

100/88 130/96 120/90 106/86 110/74

ioo/90 130/90 108/80 98/74 80/70

130/100 80/66

128/84 120/84 120/88

Reco'very :PIe (miny

1 '5 10

114/74 114/78 108/86 98/60 118/74, 128/72

122/74 120/74 120/76 114/70. '116/70 114/80 116/80 116/76 116/76

100/58 110/60 110/70 130/88 128/84 130/80 128/66 118/68 118/66 116/60 120/60, 124/64 120/62 "114/64 114/74

106/80 118/80 120/70 116/70 104/70 104/70 110/58 104/64 96/60 98/72 1i2/68 98/64

104/68 100/70 100/70

130/100 134/84: 132/80 120/80 120/80 120/70 130/68 130/64 116/60 130/70 132/70 122/70 130/78 128/78 120/74

-CI

TABLE 4 BLOOD PRESSURE RESPONSE TO 700 TILT AND RECOVERY

(mmHg)

Subject Day of Study Terminal.Time ,Tilt Time (min) Recovery Time (min).

aseline 5 10 15 Terminal 1 5 10

C14 100/55 110/70 108/70 98/80 100/76 116/65 114/60 110/60

21' R i 108/70 96/70 94/66 108/70 100/76 110/60 i0/58 104/58 R 8 100/50 102/64 94/60 96/78 104/70 108/58 104/56 110/58 R15 104/68 100/68 108/70 96/70 96/74 110/60 108/58 94/58

C14 110/70 100/84 90/84 114/88 110/98 115/80 120/80 115/68

22 R 1116/84 112/90 100/94 108/98 94/88 108/90 106/88 110/80 R 8 112/64 90/89 76/70 92/88 86/80 106/68 110/76 110/70 R15 104/64 100/84 102/78 88/74 98/76 110/56 102/64 104/64

014 108/60 106/78 110/78 110/70 100/60 110/56 110/64 110/60 R i i00/70 '102/72 100/70 98/78 98/70 108/68 100/60 98/70

23 R 3 116/68 124/74 110/80 118/78 124/78 110/60 106/66, 106/64 R 8 120/64 110/80 104/72 114/74. 110/76 114/70 114/78 110/70 Ri5 98/60 110/70 112/68 100/68 108/76 106/58 100/60 100/60

014 110/60 104/76 98/70 100/78 110/84 .108/56 118/64,----If8/60

R i 120/60 130/86 120/80 110/86 120/90 -124/70 128/80 . 120/7824 R 3 116/60 110/80 124/78 120/80 110/84 118/70 104160 104/60 R15 120/64 128/80 126/90 124/86 108/88 124/78 110/10 108/68

TABLE 5 PULSE PRESSURE RESPONSE TO 700 TILT AND RECOVERY

(mmHg)

Subject Day of Study Terminal Time Tilt Time (min) Recovery Time (mil)

-- se,'i-ne 5 10 15 Tetminal 1 5 10

48 32 30 22 22 48 36 42C14 R i 40 30 32 24' 30' 40 40 36

26 50 40' 441 R 3 46 22 32 26 R 8 42 38 28 26 22 40 40 34.

46 48Ri5 50 26 26 24 20 44

42 "32C14 38 22 22 12 16 36 34 28 20 8 16 30' 24 24Ri

2 R 3 38 14 26 20 16 36 32 36 38 24 26 24 12 36 32 28a 8

16 22 24 24 38 30 44R15 32

34 44 44C14 46 38 30 10 6 R I 32 42 40 34 24 30 40 42

3' R 3 42 42 36 30 32 36 44 36

R 8 46 34 30 40 26 44 40 44 24 46 34 36 32 36RI5 34 22

C14 30 [3 2) 32 20 M R i 11 38 22 26 4 J8 32 36

4 R3 36 40 40 40 36 30 34' 34 R 8 42 24 32 24 30 48 40 36 R15 40 26 34 40 32 .34' 32 40


Subject Day of Study Terminal Time Tilt Time (min) Recovery Time (min)

FBaseline 5 10 i Terminal" 1 5 10

t314 54 40 32 .30 28 44 50 52 R I 13.5 42 22 32 0 60 46 38

5 R 3 52 32 34 44 38 46 50 44 R 8 30 20 38 18 20 48 40 38 R15 54 26 26 0 '46 36 42

C14 36 30 30 20 28 42 38 34 * 1 13 30 22 26 12 38 32 40

6 R 3 44 26 24 22 28 40 46 42 * 8 36 26 20 22 22 32 42 38 R15 42 24 24 20 8 24 36 24

C14 34 10 20 18 12 30 26 26 R i 36 16 26 14 10 34 34 34

7 R 3 30 24 14 14 16 36 36 32 R 8 40 16.. 22 16 14 34 34 36 R15 34 20 16 22 16 34 38 38

C14 64 44 34 30 28 36 42 38 R 1 46 54 48 44 42 36 38 38 R 3 52 58 62 54 48 54 48' 50 R 8 50 28 46 48 36 42 54 50 RI5 60 50 56 42 40 56 32 48

TABLE 5 .' PULSE PRESSURE.RESPONSE TO 700 TILT AND RECOVERY

Subject .Day of Study Terminal Time . Tilt Time (min) Recovery Time (min),

-Zase~l~ine 5 10- 15 -Terminal 1 5 10

C14 62 46 40 30 32 50 42 50 R 1 46 42 30 34 32 24 32 48

9R 3 34 24 28 26 22 36 36 42 R 8 46 18 10 12 18 34 28 22 R15 38 26 22 16 28 30 20 26

C14 44 30 28 '36 36 40 36 38 R i 46 40 50, 34 42 36 38 40

.10 R 3 38 32 40 30 40 32 36 30 R 8 48 30 42 32 32 50 '40 50 Ri5. 48 38 44 28 30 46 40 52

C14 50 24 30 30 28 50 46 38 R i 60 20 16 6 30 38 44

11 R 3 42 36 32 32 28 32 46 38 R 8 42 22 38 24 30 42 40 38 R15 46 30 26 28 38 50 36 42

014 34 42 44 48 54 40 36 32 RI 44 30 34 38 58 46 36 38

12 R 3 36 '32 38 42 34 50 42 36 R 8 30 12 34 22 24 30 36 44 R15 42 32 34 40 38 36 34 42

TABLE 5 PULSK'PRESSURE RESPONSE TO 700 TILT AND RECOVERY

(mmHg)

Subject Day of Study Terminal Time Tilt Time (min) Recovery Time (m3&

• e 1a0-0- 15 Terminal 1 5 10

13

C14 R I R 3 R 8 R15

40 50 62 44 56

46 42, 38 40 38

32 36 48 24 48

26 40 50 38 40

36 32 50 20 34

42 42-64 44 50

38 40 50 46 44

36, 36 38 46 40

14

C14 R I R 3 R 8 R15

56 50 '68 56 32

50 30 34 28 18

34 24 34 18 20

42 12 36 24 12

22 32 40 30 38

64 68 62 58 36

54 50 52 54 44

50 40 50 32 28

15

c14 R i K 3 R 8

42 40 45 34

46 40 34 46

34 46 40 36

34 36 50 28

32 48 .40 36

44 52 42 36

44 48 44 42

32 .52 34 32-

R15

16

c14 R 1 R 3 R 8 R15

44 .32 32 42 22

32 34 28 20 20

'44 24 30 24 36

44 22 30 22 16

34 28 28 26 22

42 32

,36 40 32

50 36 42-40 28

42 '34 '44 38 30


(mmHg).'

Subject Day of Study.' Terminal Time Tilt Time (min) Recovery Time (min)

Base14ne 5 10 15' 'Terminal 1 5 10

C14 42 22 24 36 36 40 36 22 R 1 TIE. 40 37 0 38' 44 56

-17 R 3 40 46 30 36 30 48 46 44 R 8 44 40 40 38 22 44 46 34, RI5 46 36 36 48 40 36 40 40

C14 36 20 18 36 12 42 50 40 R i 68 30 18 50 34 42 44 50

18 R 3 54 40 54 30 30 62 50 52 R 8 70 34 40 24 '20 56 60 60 R15 56 24 44 28 36 58 50 40

C14 36 24 30 24 20 26 38 50 R 1 42 33 34 52 40 46 34 .34'

19 R 3 36 30 30 30 '28 52 40 36 R 8 44 24' 12 32 24 26 44 34 R15 38 48 40 12 10 36 30 30

C14 46 44 40 40 30 30 50 52 R 1 50 26 50 32 14 40 40 50

.20 R 3 44 52 34 50 44 62 .66 56 R 8 58 26 38 34 36 60 62' 52 R15 50 38 42 30 32 52 50 46

TABLE 5 PULSE PRESSURE RESPONSE TO 700 TILT MD RECOVERY

(mmHg)



014 45 40 38 18 24 51 54 50 21 R 1 38 26 28 38 24 50 42 46

R 8RI5 6036 3832 3438 1826 3422 5050 4850 5238

C14 40 16 6 26 12 35 40 47 22 R 1

R 3 32 48

22 6

1 6

10 4

6 6

18 38

18 34

30 40

R15 40 16 24 14 22 54 38 40

C14 48 28 32 40 40 54 46 50 R 1 30 30 30 20 28 40 40 28

23 R 3 48 50 30 40 46 50 40 42 R 8 56 30 32 40 34 44 36 .40 R15 38 40 44 32 32 48 4.0 40

C14 50 28 28 22 26 52 54 58 24 R 1R 3 6056 4430 4046 2440 30

26 5448

4844

4244

R15 56 48 36 38 20 46 40 40

TABLE 6

RESPONSE TO 700 TILT GROUP MEANS FOR PULSE PRESSURE

Day of Study Tilt Time (min) Recovery Time (min)


C14 44 31 30 29 26 41 42 41

R 1 42 31 30 29 24 40 38 39

R 3 44 32 33 33 31 45 43 41

R 8 45 28 28 27 25 42 42 39

RI5 42 30 33 28 26 42 37 38

25

TABLE 7

LIMB VOLUME q -INCREASE DURING ?0o (m/O00 1I)

TILT AND RECOVERY

Subject 'Day of Study Terminal Time Tilt Time (min) Recovery Time: (min) :(min)

5 10 15 Terminal 1 5 .10G

C14 4.8 5.8 6.2 6.8 0.4 0.6 0.4 R I 5,0 6.0 6.82 7.4 0,8 0 0.4 R 3 .2.4 2.8 3.2 3.6 -0,2 -

R 8 .B 6.5 7.1 - *O.5 -

R15 5.8 7.2 8.2 8.8 -

c14 7.5 9.8 10.4 - 4.0 3.2 R I 5.0 6.0 7.0 7.8 4.0 3.3 2.5

2 R 3 7.3 7.8 9.0 9.8' 5.6 4.8 4.8 R 8 4°6 6.2 7.5 8.6 5.0 4.7 4.6 R15 5.6 7.2 8.3 10.0 4.2 - 2.6

C14 4.8 6.5 7.8 8.0 3.8 1.8 1.8 R I 3.8 5.3 5.9 6.5 5.5 3.8 -

:3 R 3 3,3 4.5' 5.5 6.0 2.8 2.5 2.3 R 8 4.2. 5.2 5.8 6.2 4.0 3.8 -3;6 RI5 2.3 2.8 3.0 3.5 2.5- 2.5 -

C14 7.6 9.0 10.4 11.8 3.2 3.0 3.0 R 1 1I 4,8 6.6 - 7.0 5,2 4.2 4.0

4 R 3 7.6 8,2 8,6 9.0 3°8 3.4 2,8 R 8 3.4 4.4 4.8 5,6 1.4 1.2 -I5 . 6.4 8.4 9.4 10,6 2.8 3,6 3.2

TABLE 7

LIM VOLUME INCREASE DURING 700 TILT AND RECOVERY (ml/lO ml),

Subject Day of Study Terminal Time TilTime.(mn) Recovery Time(min).:(min)

5 10 15 Terminal 1 5 10

C14 3.8 5.3 5.8 6.3 -1.0 -1.0 -1.0 R 1 13.5 4.8 6.3 - 6.5 3.0 2.0 1.8

5R 3 5.3 6.3 7.8 2.0 1.5 1.3. R 8 4,0. 5.6 6.8 7.6 2.2 2.0 -

RI5 14.5 3.8 5.3 6.0 0 0 - .3

014 5.0 5.8 6.6 7.0 4.0 3.6 3.6 R 1 13 2.3 3.3 - 3.8 1.5 .8 1.0

6 R 3 2.8 3.6 4.3 5.0 2.0 1.8 1.8 R 8 2.8 3.4 4.0 4.6 1.2 1.2 1.2 RI5 3.5 4.3 5.0 5.4 0 - .3 0

014 6.0 7.0 7.8 8.2 1.8 0.8 1.0 R 1 4.2 5.8 6.6 7.0 2.6 2.2 2.1

7- R 3 5.0 5.8 6.5 6.7 2.3 '1.3 .9 R8 R15 4.8 5.4 5.9 6.6 1.7 1.6 1.7

014 3.0 4.0 5.3 6.0 2.3 1.3 Lo Ri 5.8 5.8 6.4 7.2 1.0 0

8 R 3 .5.4 6.4 6.6 7.2 2.8 2.2 2.2 R 8 5.0 6.1 6.5 7.0 1.5 1.5 1.5 R15 .4.8 5.8 6.6 6.6 1.8 0.8 1.2

TABIE 7

LIM VOLUME INCREASE DURING 790 TILT AND RECOVERY (ml/lq mA


5 10 15 Terminal 1 5 10

C14 4.6 5.8 7.0 8.8 2.2 1.8 1.8 R 1 3.8 5.0 6.0 6.4 - - 1.6

10 R 3 5.0 6.5 7.3 8.0 3.0 2.5 2.0 R 8 4.2 5.4 6.6 7.8 1o8 1.6 1.6 RI5 4.6 6.0 6.6 7.0 1.2 0.6 0.8

014 5.5 6.8 6.8 7.9 0.1 - .1 .1 R i 10.5 4.8 6.0 6.0 1.0 0 0

11 R 3 6.8 8.0 9.0 10.0 1.3 1.0 015 R 8 4.4 5.6 6.4 7.2 1.0 0.8 0.6 RI5 5.6 6.6 7.4 8.0 0.4 0.4

C14 11.0 12.0 13.0 13.7 2.0 1.0 .4 Ri 4.8 6.3 7,0 7.5 1.0 0 0

12 R 3 6.3 8.0 9.0 9°8 5.0 3.8 3.0 R 8 4.8 5.8 6,6 7.6 3.0 Z.2 2.2 RI5 6°4 8.0 8.6 9,01 1.6 0.8

c14 7.8 9.9 10.0 11.0 0.5 0.3 0.3 R I 4°4 5.3 6.0 6.8 0.8 0 -0.3

13 R 3 4°4 5°8 6.6 - 2.2 2.0 1.4 R 8 4.6 5.6 6°8 7.6 3,0 2,6 2.0 R15 6°0 7.0 8.2 9.2 0.8 0.2 0.2

TABLE 7

LIMB VOLUME INCREASE DURING 700 TILT AND RECOVERY (m/OO 'pl>

Subject Day of Study Terminal -Time<mit)

Tilt Time (min) Recovery Time (min)

5 10 15 Terminal 1 5 iO

C14 4.8 5.8 6.6 7;2 1.2 1.2 R i 2.6 3.6 4.4 5.0 2.4 0

14 R 3 4.0 5.8 - - 3.2 2.4 1.8 * 8 4.6 6.0 6°8 7.6 0.8 0.8 0.6 R15 5.0 6,2 7.0 7.6 2,0 1.6 1.6

C14 6.0 7.3 7.8 8.8 3.0 2.5 2.5 R i 5.0 6.5 7.3 8.1 4.5 3.5 3.8

15 R 3 6.0 6.3 6.9 7.8 3.8 3.8 3.3 R8

C14 6.2 7.6 8.2 9.2 3.6 3.0 2.4 R 1. 6.6 7.8 - 2.0 1.6 1.6

16 R 3 5.4 7.2 8.2 9.6 2.8 2.0 2.4 R 8 4.2 5.8 7.2 8.4 1.8 1.0 1.0 R15 4.4 5.4 6.4 6.8 1.0 0.4 0.6

C14 9.2 11.1 11.9 13.2 1.6"- -0.5 1I. R i 8.5 5.2 8.6 2.0 1.2 1.0

17 R 3 6.2 8.2 9.2 10.0 5.0 4°6 3.0 R 8 5.6 9.0 9.4 10.4 5.2 5.2 5.6 R15 10.0 10.6 11.8 12.0 3.0 2.4 2.2

TAKLE 7

LINE VOLUM INCREASE DURING 700 TILT AND RECOVERY (ml/lO0 ml>

Subject Day of Study' Terminar Time Tilt.Tme (min) Recovery Time (min)

5 1.0 15 Terminal 1 5 10

18

C14 R i R 3 R 8 R15

7.1 5.2 7.6' 6.0 9.4

8.1 7.4 9.4 7.4

11.4

9.0 9.0

11.0 8.6

12.0

9.7 10.0 12.2 9.6

12.8

3.2 2.0 5.0 3.0 4.4

2.4 0.5 4.4 2.7 4.2

2.9 1.2 4.2 2.4 4.4

19

C14 R I R 3 R 8 R15 014

5.5 3.4 4.4 3.6 3.8 7.0

6.8 4.8 5.4 3.0 4.8 9;4

8.0 5.6 6.6 6.0 5.2

10,2

8.8 6.4 7.2 6.8 5.8

10,8

3.5 3.4 4.0 2.0 1.4 2.6

2.Q 2.6 3.2 1.4 0 2.4

2.8 2.8

.3.2. 1.2 0 2.6

20 R I R 3 R 8 R15

5.0 4.6 5.6 5.4

6.6 5.8 7.4 6.6

8.4 7.2 8.8 8.2

9.6 8.2

10.0 8.4

6.0 3.6 4.0 4.0

4.4 3.4 3.8 3.4

5.0 3.4 3.8 3.2

21

C14 R i R 8 R15

5.8 3.8 1.4 3.0

6.8 5.0 2.6 4.0

7.4 5.8 3°6 5.0

8.4 6.4 4.4 5.8

1.2 1.8 2.2 2.8

0.4 1.2 1.8 2.8

0.6 1.2 1.4 2.6

TABLE 7

LIMB VOLUME INCREASE DURING 70c TILT.AND RECOVERY (ml/100 ml)

.Subject Day of Study Terminal Time s,(mixr)

TilP.Time (min) Recovery Time (min)

5 10 15 Terminal 1 5 10

22

014 R i R 8

10.8 5.2 3.4

12.4 7.6 5.2

14.4 9.0 6.8

15.0 10.2 8.0

2.6' 4.0 3.2

0.8 1.6 2.4

0 1.4 2.4

RI5 6o0 8.0 9.6 11.0 0 0 0

C14 7.4 8,8 9°2 10.8 3.8 2.6 2.4

23 R R 3

4.6 6.4

6.2 8.0

7.2 9.2

8°0 10.4

3.0 4.4

1.6 3.8

1.8 3.6

R 8 6.8 8.0 9°2 10.4 4.0 3.2 .3.2 R15 7.6 9.0 10.6 11.2 4.6 4.4 4.2

014 9.6 11.6 12.8 13.8 2.8 2.2 142

24 R i R 3

7.2 5.4

9.4 7.6,

10.8 9.0

12.4 10.0

3.4 2.0

2.6 1.2

2°2 0.8

R15 5°0 6.2 7.2 8.2 1.0 0.4 0.2

TABLE 8

EART-ItATE-RESPONSE TO EXERCISE AND RECOVERY

*Exetcfse Level Recovery Time (min)

Subject. Day of Study Rest 50W 75W 100W 1 2 3 4 5 10

C14 55 99 121 134 '108 103 87 84 85 73 R 1 70 110 135. 155 130 115 105 100 100' 90 R 3. 70 105. 130 153 130 110 110 105 100 90 R 8 72 105. .131 160 130 125 115 110 105 100 RI5 70 110 135 150 110 105 110 110 90 90

C14 57 86 94 121 100 90 85 82 80 80 R 1 60 102 . 120 140 105 100 100 100 94 88

2 R 3 58 93 114 138 .98 100 98 94 90 90 R 8 60 90 104 131 90 88 80 76 72 75 RI5 64 95 107 125 100 85 88 85 75 70

C14 66 120 120 154 138 120 100 100 100 100 R 1 '87 133 156 175 150 142 133 120 120 120

3 R 3 60 109 135 158 125 110 100 99 90 88 R 8 65 110 135 150 130 115 115 105 100 90 RI5 70 113 134 157 140 120 104 100 100 100

C14 60 85 93 '115 95 85 80 75 75 75 R 1 68 98 113 140 120 110 100 100 95 90

.4 -R 3 75 100 120 140 118 110 100 100 100 -80 R 8 65 100 110 133 110 110 100 95 90 85 R15 55 93 103 123 105 90 90 85 80 75

C14 62 109 131 161 135 118 112 106 106 95 R I 62 113 147 165. 142 132 125 120 112 110

5R 3 66 I1 .128 154 125 116 110 105 104 87 R 8 70 .115 125 160 130 . 120 105 105 105 90

'RI5 68 115 137 154 131 118 114 108 102 100

TABLE 8

HEART RATE RESPONSE TO EXERCISE AND RECOVERY

Exercise Level Recovery Time. (min)

Subject Day of Study Rest 50W 75W 100W 1 2 3 4 5 10

C14 60 100 120 155 100 95 95 90 90 90 R 1 62 109 159. 185 106 85 87 85 '80 86. R. 3 62 116 143 172 137 115 106 100 I00 95 R 8 65 115 138 .173 .135 120 115 110 110 95 R15 52 100 123 158 114 104 "- 98 98 87 82

014 55 100 135 173 130 120 100 105 95 85 R 1 55 103 140 170 160 150 130 110 115 100

7 R 3 54 101 163 168 140 125 120 105 98 84 R15 50 95 120 155 140 115 100 105 90 90

014 100 125 140 160 140 120 120 '115 110 100 R,1 100 128 138 165 140 125 120 115 120 115

8R 3 85 115 130 130 1.10 100 85 90 100 100 R 8 72 106' 122 144 120 110 110 110 110 100 R15 85 120 143 155 140 130 120 120- 120 105

C14 75 125 148 168 140 120 120 120 110 100 R 1 80 110 155 175 150 140' 130 130 120 1i0

9 l 3 68 119 150 171 140 .130.' 120 115 112 100 R 8 75 . 108 133 165 125 120 120 110 100 90 R15 75 105 130 148 125 115 i10 105 100 95

C14 90' 123 153 165 155 140 130 120 120 110 R 1 80 '118 125 160 140 125 115 105 105 100

10 R 3 70 i15 140 162 130 120 i15 108 110 98 R 8 80 145 160 188 170 155 140 140 140 135 R15 75 110 125 153 120 115 110 100 100 95

TABLE 8

HEART RATE RESPONSE TO EXERCISE AND RECOVERY

Exercise Level Recovery Time (min)

Subject. Day of Study Rest 50W 75W 10OW 1 2 3 4 5 "10

C14 65 S9 103 134 R 1 65 100 124 150

1 R 3 64 105 118 144 110 102 100, 104 100 90 R 8 60 95 120 155 106 it0 i00 95 95 90

RI5 50 88 105 133 115 .00 100 .90 90 80

C14 60 92 111 138 102 88 86 79 72 70 R 1 65 104 130 1S2 118 100 96 100 86 85

12' R 3 73 108 133 163 110 100 96 94 96 88

R 8 50 95 120 155 100 100 95 90 80 90

R15 60 105 135 155 105 100 85 90 95 85

C14 64 91 108 134 10 100 95 92 92 94

R 1 7.0 98 118 150 130 128 113 10 108 100 100 120 145 115 100 95 95 .95 9013 .R 3 70

R 8 75 100 118 '138 110 105 95 95 95 88 RI5 60 90 108 130 110 .95 95 90 80 80

C14 58 98 112 130 105 85 85 80 80 70

R 1 55 105 120 150 130 120 110 100 95 85

.14 R 3 60 110 118 143 110 100 85 90 80 75

R 8 60 98 113 130 100 80 75 75 75 70

R15 60' 93 110 133 100 80 80 80 80 75

C14 64 86 110 125 86 85 72 75 74 67

R I 75 91 104 129 101 95 94 88 83, 73

R 3 72 106 125 139 100 90 96 90 87 - 90.

TABLE 8

HEART-RATE,RESPONSE TO EXERCISE AND RECOVERY

Exercise Level Recovery Time (min)

Subject 'Day of Study ' Rest 50W 75W 100W 125W. 15M 1 2 3 4 5 10

C14 50 78 90 105 80 70 70 60 70 70 R i 65 100 110 140 110 90 85 80 90 80

16 R 3 70 90 108. 130 80 75 75 75 80. 75 R 8 65 90 113 125 100 80 80 75 75 75 R15 55 85 103 123 90 75 75 75 75 80

C14 60 98 125 160 108 97 99 96' 96. 94 R 1 56 80 117

17 R *80 105 130 156 102 98 94 92 92 §1 R 8 48 99 120 149 106 97 85 88 82 77 RI5 43 90 110 145 108 98 88 88 84 82

C14 54 133 168 180 2 ' 150 132 115 110 .107 100 .Ri 55 136 155 .1632 116 110 103 100 96' 94

18 R 3 56. 135 167 1803 150 130 111 97 97 97 R 8 47 130 165 1631 141 122 108 104 '-99 80 R15 80 138 168 1852 156 137 130 122 ,121 109

C14 62' 103 132 160 195' 2201 160 150 140 130 124 114 R 1 80 108 148 180 195 150 140 125 120 120---115

19 R 3 72 95 130 163 185 2002 160 140 125 117 115 ' 105 R 8 60 105 133 168 185 2002 165 140 125 125 .115 110 RI5 65 95 130 160 188 2003 165 140 130 125 120 120

C14. 60 90 110 150 1661 138 118 115 91 96 77 R 1 65 10,6 120 155 180 3 1'35 130 115 115 110 '105

20 R 3 50 95 115 138 1602 125 112 '105 96 .90 82 R 8 60 100 120 145 173 13Q 120 120 112 107 100 RI5 60 98 115 148 170 140 120 120 115 110 90

TABIR 8

HEART RATEFRESPONSE TO EXERCISE AND RECOVERY

,Exercise,'Level Recovery Time (min)

Subject' Day of Study Rest !00W 125W 150W 175W 1 2 3 4 5 10

C14 55 148 1602 125 108 98 110 94 94 21R IR 8 5050 140140 1401

-1652 D10120 90

110 8595 75

90 8590

8085

RI5 55" 133 1603 120 115 95 85 85 85

C14 65 125 153 173 180 140 135 120 115 110 110

22 R 1 R 8

95 70

131 133

165 160

1751 145 135

120 120

115 "115

115 .119

115 1.10

110 110

R15 70 125 153 130 120 120 115 125 115

014 56 108 140 1602 120 100 90 80 80 75 R 1 55 143. 178 150 130 120 110 110 100

23 R 3 75 143 180 155 140 120 115 105 100 R 8 55. 120 155 1753 145 120 100 100 100 85 RI5 60 130 155 1703 150 125 115. 105 100 100

014 65. 135 168 178 140 120 110 110 110 100 24 R 1R 8 9085 160145 175173 75150. 85125 80130 80125 95125 105120

Ri5 70 133 163 135 130 120 110 115 105

C03

TABLE 9

RESPONSE TO EXERCISE GROUP MEANS FOR HEART RATE

Exercise Level

Day of Study Baseline 50W 100W.

C14 Mean 66 .'101 117 141.

SE ±8 ± 9 ±12 ±11

R1I Mean 71 109 132 157

SE ±7 ±6 ±10 ±8

150R 3 Mean 68 107 128

SE ±4 ±5 -7 ±8

R 8 Mean 67 .105 124 151

SE ±5 ± 8 ± 8 ±11

143R1 Mean 64 102 121

SE ±6 ±6 ±8 ±8

TABLE 10

RESPONSE TO EXERCISE PAIRED "t" TEST ANALYSIS

HEART RATE RESPONSE TO EXERCISE (P)

Day of Study

Day of Study Exercise Level R1 R3 R8 R15

Baseline <.05 <.6 <.8 <.6

<.9<.01 <.I <.3

75W <.01 <.o01 <.I <.4

100W <.005 <.05 <.02 <.6

4 50W

Baseline <.4 <.2 <.01

R I 50W <.4 <.3 <.001

75W <.2 <.I <.005

100W <.05 <.I <.005

38

TABLE 11 RESPONSE TO EXERCISE

GROUP MEANS MEART RATE RECOVERY FOLL ING 100 WATT EXERCISE

Day of Study

.1 2

Recovery Time (min)

3 4 5 10

C14 Mean SE

116 ±14

103

±+12

97

ti-

93

±11

92

±10

87

±9

RRI Mean

SE

129

±16

116

±11

109

-9

105

±8

102

8

97

±8

R 3 Mean SE

118 ±10

107 ± 8

100 ± 8

98 6

97

6

89

±5

R 8 Mean SE

119

±13

110 .

±12

103

±11

100

ill

97

±11

91

±10

R1 Mean SE

115 ±9

102 ±10

98 -9.

96

±8

91

±8

87

±7

,39

TABLE 12

HEART RATE

RESPONSE TO EXERCISE PAIRED "t" TEST ANALYSIL

RECOVERY FOLLUINc 100 WATT EXERCISE

Day of Study Time (min)

1

2

RI

<.005

<.005

Day of Study

R3 R8

<.8 <.5

<.4 <.o05

R15

<.7

<.9

C14 3 <.01

<.005

<.6

<.3

<2

<<

<.8

<.4

5

10

<.o01

<.005

<.2

<.5

<.2

<3

<.9

<.9

1

2

<.05

<.I

<.I

<.4

<.001

<.01

R 3

4

.5

10

<.05

<.05

<.2

<.025

<.3

<.4

<.4

<.3

<.o01

<.02

<.o:05

<.001

40

TABLE 13

RESPONSE TO EXERCISE:OXYGEN CONSUMPTION (ml/min),

Subject Day of Study, Baseline 50W

C14 229 880 R 1 245 860 R 3 237 812 'R 8 231 870 RI5 241 919

C14 203 832 R 1 225 890

2 R 3 183 765 R 8 222 760 R15 .239 795

014 198 876 R 1 194 928

3 R 3 235 911 R 8 230 924 RI5 228 812

C14 267 905 R 1- 252 985

4 R 3 220 863 R 8 219 870 R15 247 901'

75W 100W

1212 1548 1250 .1544 1168 1345 1096 1620 1337 1599

1065 1440 1066 1440 1140 1489 1069 1474 1090 1440

1108 1505 1320 1565 1255 1645 1254 1610 1191 1517

1243 1629 1190 1520 1217 1537 1165 1649 1274 1677

TABLE 13

RESPONSE TO EXERCISE:OXYGEN CONSUMPTION (m1/m$ ).

Subject Day bfStudy Baseline 50W

C14 281 982 R 1 228 936

5 R 3 213 919 R 8 196 966 RI5 212 895

C14 227 835 R 1 198 874

6 R 3 181 794 R 8 165 797 RI5 157 808

C14 191 1024 R 1 236 934

8 R 3 271 935 R 8 210 843 R15 226 842

C14 240 1027 R 1 226 1005

9 R 3 116 1003 R 8 186 990 R15 150 1007

75W

1360 1299 1223 1194 1200

1148 1331 1268 1112 .,988

1241 1135 1196 1090 1268

1409 1393 1432 1252 1307

100W

1808 1560 1503 1548 1361

1627 1668 1825 1573 1750

1451 1393 1149 1448 1567

1771 1716 1800 1654 1755

RESPONSE-TO

Subject Day of Study

10'

C14 R 1 11 3 R 8 R15

11.

C14 R 1 R 3 R 8 RI5

12

C14 R 1 R 3 R 8 R15

13

C14 .R 1 R 3 R 8 RI5

TABLE 13

EXERCISE:OXYGEN CONSUMPTION

Baseline 50W

198 MS 204 922 211 878 227 1048 201 940

236 937 224 914 239 987 176 880 200 910

200 880 198 1000 203 881 202 889 193 883

209 876 228 860 236 917 256 908 228 872

75W 10VI

1200 1150 1204 1232 1239

1552 1605 1560 1659 1566

1229 1279 1299 1415 1216

1679 1581 1726 1765 1596

1190 1258 1281 1500 1205

1448 1529 1545 1607 1526

1153 1154 1041 1263 1234

1552 1627 1696 1614 1552

TABLE 13

RESPONSE TO EXERCISE:OXYGEN CONSUMPTION (ml/min),

Subject Day of Study Baseline 50W 75W 100W

c14 274 804 1226 1570 R 1 301 872 1136 1586

14 R 3 259 936 1211 1750 R 8 .252 746 1249 1672 RI5 293 925 1325 1817

C14 235 859 1172 1452 R 1 .206 853 1141 1510

" 16 R 3 238 874 1249 1648

R 8 183 896 1136 1527 RI5 172 822 1159 1497

C14 221 883 1127 1594 R 1 206 854 1195 1578

'19 R 3 205 806 1213 1596 R 8 199' 848 123& 1699 RI5 196 822 1152 1561

014 265 941 1210 1736 R 1 264 904 1257 1696

20 R 3 1274 909 1243 1743 R 8 1267 906 1224 1699 RI5 276 888 1214 1627

TABLE 13

RESPONSE TO EXERCISE : OXYGEN CONSUMPTION (ml/min)


C14 135 699 1163 1639

R 1 138 846 1125 7 R 3 191 782 1198 1494

R 8 174 829 1104 1794 152 788 1126 1510RI5

1564014 221 966 R 1 247 914 1112 1459

15 R 3 198 851 1223 1493

R 8 208 921 1189 1582

255 856 1241 1796014 R 1 155 863 1250

197 869 1258 159817 R 3 168 846 1215 1670R 8

1193 1760RI5 170 766

Data used only in calculation of Maximal Oxygen Uptake.

TABLE 13

RESPONSE TO EXERCISE : OXYGEN CONSUMPTION

(rl/min)

Subject Day of Study Baseline 100W

C14 284 1550 R 1 277 1554

18 R 3 222 1594 R 8 224 1600 RI5 253 1586

014 205 1244 R 1 209 1552 R 8 202 1523

Ri5 180 1478

C14 287 1614 190 166022 R 1

R 8 203 1323 R15 208 1570

C14 264 1648 R 1 250 1638

23 K 3 288 1624 R 8 232 1563 Ri5 298 1557

C14 262 1583 R 1 257 1681 R 3 257 1501

RI5 247 1527

125W 150W

2183 2613 2027 2249 2109 2540 2151 2435 2156 2453

2267

1924

1877

2134 2579 2205 2028 2083 2495

2171 2352 2325 2175 2545 2209 2482

2143 '2659

2252

2020

Data used only in c Iculation of Maximal Oxygen Uptake.

TABLE 14

RESPONSE TO EXERCISE GROUP MEANS FOR OXYGEN CONSUMPTION

(ml/min)

Exercise Level

Day of Study Baseline 50W 75W 100W

1206 1585C-14 Mean 230 902

SE ±16 ±35 246 ±62

R 1 Mean 227 912 1222 1570

SE ±15 ±27 248 ±45

220 886 1227 1597R 3 Mean

SE ±21 ±36 ±44 ±94

Mean 214 884 .1218 1614R 8 SE ±16- ±42 ± 61 ± 45

R1 Mean 216 878 1212 1590

SE ±21 ±31 247 ±63

47

RESPONSE

Subject Day of'Study

014 R 1 RR 3 R 8 RI5

2

c14 R 1 R 3 R 8 RI5

3

C14 R 1 R 3 R 8

R15

4

C14 R 1 R 3 R 8 R15

TABLE 15

TO EXERCISE:MINUTE (m1/min

Baseline

6031 7305 6936 6895 6740

"7124 9230 6286 8273 9313

6012 6173 7415 7201 9542

7561 8579 6351 6800 6319

VENTILATION

50W

22209 21819 20861 22253 24139

21662 28595 18569 20257 23414

20434 24160 22100 21782 21922

18812 27033 20187 19620 20190

75W I00W

30475 43160 33242 43973 31306 40606 29625 48303 38103 47399

27671 41454 33140 49678 30463 51817 29057 43473 31220 45601

28452 38878 37785 44650. 32103 49858 31289 45506 35760 50613

23722 33108 31503 41721 30975 41532 28133 45317 30426 40901

TABLE 15

RESPONSE TO EXERCISE:NINUTE VENTILATION


C14 R 1

5 R 3 R 8 R15

C14 R 1

6 R 3 R 8 R15

C14 R 1

8 R 3 R 8 R1b

C14 R 1

9 R 3 R 8 R15

(ml/min)r

Baseline

11921 8406 6972 6315 6706

10725' 7997 6490 5977 5215

4364 5457 6350 4843 5144

5913 6646 3299 4534 3630

50W

25618 24339 21854 23238 22422

31363 32782 29665 26825. 25367

20217 20860 20009 17733 19084

21104 22388 20222 18236 17040

75W 100W

38211 33953 30760 29376 30475

53472 45703 40490 40587. 42336

37541 54648 45340 40507 39132

63709 74432 87419 70444 82948

25790 26897 26039 23825 27389

37087 34674 23587 33318 38740

27960 30586 30120 23274 25476

41530 40014 39925 34154 36894

TABLE 15

RESPONSE TO EXERCISE:IfNUTE (ml/min.

Subject Day of.-Study Baseline

10

C14 R 1 R 3 R 8 R15

5002 4506 4932 5429 4127

11

C14 R 1 R 3 R 8 R15

6418 6244 6457 4884 5298

12

C14 'R 1 R 3 R 8 RI5

5345 5148 5706 5833 57.i2

13

C14 R 1 R 3 R 8 RI5

4423 5180 5322 5766 5109

CA C

VENTILATION

50W

18264 20009 17561 24125 19216

24095 22977 25369 22954 21569

20218 20507 20153 19511 21464

17845 20121 21751 20470 19407

75W

24126 25261, 25757 25331 26005

30229 34128 36223 41013 31326

26568 25783 30834 35934 28630

24941 27605 25433 29234 29452

100W

33586 41722 37748 40113 38930

42531 46354 49475 55110 46026

24765 32048 37702 38742 37086

38032 44561 44798 41864 40445

TABLE 15

RESPONSE TO EXERCISE:VMINUTE VENTILATION (mh/mt\

Subject Day of Sjudy Baseline 50W

14 8369 17702 R 1 11327 21533 R 3 8041 2291814 R 8 8097 20009 RI5 10010 22251

C14 6138 19370 R 1 6081 20967

16 R 3 6364 21003 R 8 4896 22413 RI5 4528 17676

014 8470 21362 R 1 7684 23371

7421 2133019 R 3 R 8 7073 22657 R15 8128 22118

014 7607 24096 R 1 7499 21757

20 R 3 8440 21579 R 8 8595 22150 RI5 8692 21611

75W 100W

26967 35240 26428 42668 32497 48535 29163 42195 31818 44271

27211 34248 27247 37180 29291 42218 27814 55381 22726 31995

30929 42342 33739 48718 33912 46116 33588 51991 31860 47433

30174 46130 30893 44775 28988 43395 29851 45457 30175 42801

TABLE 15 *

RESPONSE TO EXERCISE : MINUTE VENTILATION (mi/min)


014 6918 21499 33703 57805 R 1 6874 24329 35336

7 R 3 6598 20931 36476 58184 R 8 5350 22529 32022 63244 R15 5452 21859 34949 51041

014 6155 21781 22539 R 1 8597 24268 28631 38081R 3 5227 19440 26968 33868

R 8 5889 21073 27780 37181

014 11525 26181 39416 64304 R 1 4676 21651 39292

17 R 3 5622 25283 39273 54809 R 8 5359 23593 36180 57902 RI5 7097 20788 37361 62031

TABLE 15

RESPONSE TO EXERCISE : I (ml/min)

UTE VENTILATION

Subject Day of Study. Baseline 100W 125W 150W

21

014

R 1 R 8 R15

6690 7756 6725 6321

40069 56932 57878 51602

86864

88038 82718

22

C14 R 1 R 8

R15

7787 4075 3951

4412

32224 32907 20389

28915

45075 52383 52219

58212

65425

91996

23

C14 R 1 R 3 R 8 R15

9051 7277 9063 8002 9404

48373 51116 46526 48417 45338

70092 86097 73937 72327 72500

96455 99910

24

C14 R 1 R 8

RI5

7912 7300 6995

7229

42725 55436 42341

46116

62726

78641 67900

89187

Data not used.

TABLE 16

RESPONSE TO EXERCISE GROUP IAANS FOR MINUTE VENTILATION

(L/min)

Exercise Level

Day of Study

C14 Mean SE

R I Mean

SE

f 3 Mean SE

R 8 Mean SE

Mean

SE

Baseline

6.96

±1.13

7.09

± .95

6.42 + .66

6.31

± .70

6.58

±1.15

50W

21.52'

±1.86

23,32

±1.86

21.57 ±1.48

21.52

±1.24

21o18

±1.21

75W .100

28.81

±2.22

41.20

±4.28

32.05

.±3.76

44.55

±4.94

31.25 ±2.52

45.33

±6.95

30.44

±2.73

44.50

±4.87

30.62

±2.32

44.65

±6.01.

TABLE 17

RESPONSE TO EXERCISE PAIRED "t" TEST ANALYSIS PRE-BEDREST vs RECOVERY

Oxygen Consumption Minute Ventilation

Exercise Recovery Day Recovery Day Level 1 3 8 15 1 3 8 15

Baseline <.7 <.5 <.2 <.3 <.8 <.3 <.3 <.6

50W <.5 <.4 <.4 <.2 <.025 <.9 <.9 <.7

75W <.5 <.4 <.8 <.8 <.02. <.02 <.2 <.2

100W <.5 <.8 <.3 <.9 <.025 <.2 <.1 <.1

TABLE 18'

RESPONSE TO EXERCISE VENTILATORY EQUIVALENT

Liters/lO0 ml 02,


C14 .R 1 RR 3 R 8 R15

2.63 2.98 2.93 2.99 2.80

2.52 2.54 2.57 2.56 2.63

2.51 2.66 2.68 2.70 2.85

2.79 2.85 3.02 2.98 2.96

2

C14 .R 1 R 3 R 8 R15

3.51 4.10 3.44 3.73 3.90

2.60 3.21 2.43 2.67 2.94

2.60 3.11 2.67 2.72 2.86

2.88 3.45 3,48 2.95 3.17

3

c14 R i R 3 R 8 R15

3.04 3.18 3.16 3.13 4.18

2.33 2.60 2.43 2.36 2.70

2.57 2.86 2.56 2.50 3.00

2'.58 2.85 3.03 2.83 3.34

4

C14 R 1 R 3 R 8 R15

2.83 3.40 2.89 3.11 2.56

2.08 2.74 2.34 2.26 2.24

1.91 2.65 2,55 2.41 2.39

2.03 2.74 2.70 2.75 2.44

TABLE 18

RESPONSE Td EXERCISE VENTILATORY EQUIVALENT

Liters/100 ml 02

Subject Day of Study ..Baseline 50W 75W 10OW

5

'C14 R 1 R,3 R 8 RI5

4.24 3.69 3,27 3.22 3.17

2.61 2.60 2.38 2.41 2.51

2.81 2.61 2.52 2.46 2.54

2.96 2,93 2.69 2.62 3.11

6

C14 R 1 R 3 R 8 R14

4.72 4.04 3;59 3.62 3.32

3.76 3.75 3.74 3.37 3.14

3.27 4.11 3.58 3.64 3.95

3.92 4.46 4.79 4.48 4.74

8

C14 R 1 R 3 R 8 R15

2.28 2,31 2.34 2.30 2.27

1.97 2.23 2.14 2.10 2.27

2.08 2.37 2.18 2.19 2.16

2.56 2.49 2.05 2.31 2.47

9

C14 R 1 R 3 R 8 R15

2.46 2.94 2,84 2.44 2.42

2.05 2.23 2.02 1.84 1,69

1.98 2.20 2.10 1.86 1.95

2.35 2.33 2.22 2.06 210

CAi ",

TABLE 18

RESPONSE TO EXERCISE

VENTILATORY EQUIVALENT

Liters/100 ml 02

Subject Day of Study Baseline 50W 75W I9OW

C14 2,53 2.06 2.01 2.16 R 1 2.21 2.17 2.20 2.60

10 ,R 3 2.34 2.00 2.14 2.42 K 8 2.39 2.30 2.06 2.42 RI5 2.05 2.04 2.10 2.49

C14 2.72 2.57 2.46 2.53 K 1 2.79 2.51 2.67 2.93

11 R 3 2.70 2,57 2.79 2q87 R 8 2.77 2.61 2.90 3.12 R15 2.65 2.37 2.58 2.88

C14 2.68 2.30 2,23 2.40

R i 2.60 2.05 2.05 2.10 12 R 3 2.81 2.29 2.41 2.44

R 8 2.64 2.19 2.40 2.41 R15 2.96 2.43 2.38 2.43

C14 2.11 2.04 2.16 2.45 R 1 2.27 2.34 2.39 2.74

13 R 3 2.25 2°37 2.44 2.64 R 8 2,25 2,25 2.31 2.59 R15 2,24 2,23 2.39 2,56

TABLE 18

RESPONSE TO EXERCISE VENTI LATORY EQUIVALENT

Liters/tO0 ml 02


C14 3.05 2.20 2.20 2.24 R 1 3.76 2.47 2.33 2.69

14 ,R 3 3.10 2.45 2.68 2.77 R 8 3.21 2.68 2.33 2.52 R15

014 2.61 2.25 2.32 2.36 R 1 2.95 2,46 2,39 2.46

16 R 3 2.68 2.40 2.35 2,56 R 8 2,67 2.51 2.45 2.32 RI5 2.63 2.15 1.96 2.14

C14 3.83 2.42 2.74 2.66 R 1 3.73 2.74 2.82 3.09

19 R 3 3.62 2.65 2.80 2.89 R 8 3.55 2.67 2,72 3.06 RI5 4.15 2,69 2.77 3.04

C14 2.87 2.56 2.49 2o66 R 1 2°84 2.41 2,46 2.64

20 R.3 3.08 2.37 2.33 2.49 R 8 3.22 2.44 2.44 2.68 R15 3.15 2.43 2,49 2.63

TABLE 19

GROUP RESPONSE TO EXERCISE

MEANS FOR VENTILATORY EQUIVALENT Liters/100 ml 02

Day of Study Baseline 50W 75W 100W

C14 Mean SE

3.00

±.36

2.39

±.21

2.40

±.19

2.59

±.23

R 1 Mean

SE

3.11

±.30

2.56

±.21

2.62

±.26

2.83

L.28

R Mean SE

2.94

±.21

2.44

±.19

2.55

i.19

2.81

±.34

R 8 Mean SE

2.95

±.21

2.45

±.17

2.51

±.21

2.76

-.30

RI5 Mean SE

2.97 ±.30

2.43

-19 2.54

E.26

2.83

±.36

60

TABLE- 20

DERIVED MAXIMAL OXYGEN UPTkKE

Subject rta

1

.2

3

4

5

6

2235

2684

1916

3363

2104

2013

7

8

9

10

11

12

13

14

1730

2085

1946

1780

2780

2262

2512

2458

15

16

2889

3153

17

18

19

-20

21.

22

23

24

2098

2487

1814

2267

2394

2851

3108

2546

Mean 2395

SE (95%) ±192

p

(ml/min)

Day of Study

RI R3

1934 1801

2021 -2199

1669 1931

2357 2416

-1750 1946,

1618 1872

1680 1536

1823 2199

1852 1947

2034 1809

2143 2422

2044 1920

2209 2337

1958 2345

2812. Z285

2294 2903

2557 2141 .

2471 2430

1712 2046

2077 2401

2147

2891

2336 2331

2087 2362

2103 2163

±144 ±133

< 001 <.005

R8 RI5

1929

2379

2034

2628

1951

1659

20&5

2011

1523.

2326

2188

2581

2662

2105

2523

1860

2882

1757>

1998

1874

2001

2471

2151

2449

1867

2605

2789

2705

2107

2567

2046

2336

2133

2365

2665

2646

2286

2400

2036

2206

2219

2757

2662

2383

2232 2301

±152 ±143

<.02 <.30

COI

TABLE 21

DERIVED MAXIMAL OXYGEN UPTAKE (ml/kg x min)

Subject Day Of Study

C14 R I R 3 R 8 RI5

1 34.4 30.0 28.0 29.9 32.1 2 41.7 31.9 34.4 37.3 39.1 3 29.0 24.9 28.5 29.9 27.4 4 46.6 33.3 33.8 36.7 40.4 5 36.2 30.6 33.7 34.1 30.6 6 32.3 26.7 30.8 27.4 33.0 7 28.6 27.8 25.3 30.9 8 25.3 22.0 26°4 25.1 24.1 9 28.6 27.5 28.9 30.1 37.3

10 20.8 23,5 20.8 17.5 24.8 11 40.9 31.6 35.3 34.3 36.3 12 35.0 31.5 29.5 33.7 28.8 13 36.3 32.3 33.8 37.4 37.8 14 34.8 27.9 33.4 38.1 40.2 15 30.1 34.9 28.2 16 47.8 35.1 44.8 42.0 41.1 17 38.0 46.1 38.3 38.0 41.2 18 35.5 36.0 34.9 37.1 34.3 19 28.2 26.5 31.5 31.6 31.5 20 28.7 26.5 30.7 29.8 28.3 21 36.3 32.1 31.8 32.9 22 34,6 35.9 29.1 34.3 23 42.2 32.9 32.9 36.8 36.5 24 34.5 284 31.9 32.1

Mean 34.4 30.7 31.6 32.7 33.7

SE (95%) ±2.7 ±2.1 ±2.2 ±2.5 ±2.2

P <.005 <.005 <.025 <0.4

TABLE 22

PULMONARY FUNCTION

Subject

VC

Before Bedrest * F-VI* * * FE- RV TLC

1 1 1~

* DCO 1

1

* VO2 22

After Bedrest * * *

FEV-!2 RV2 TCL 2 22

* DCO 2

5 6, 7 8

11 12 .13 14 15 16 17 18 19 21 22 23 24

5.07 4.36 4.49 5.23 3.89 5.20 5.07 5.40 4.61 5.27 3.39 4.62 5.03 5.16 4.98 4.34 4.97

4.24 3.62 3.90 3.91 3.25 4.37 3.79 3.92 3.81 4.51 3.02 3.96 4.03 3.84 3.45 3.34 3.51

.95 1.00

.94

.74 1.02 1.51 1.86 1.66 1.35

6.02 6.66

4.34 5.46 6.07 6.72 7.09 6.54 6,44

36.1 33.8 36,6 32.2

34,3 48.0 28,2' 44.0

5.08 4.47 4.64 4.99 4,32 5.88 5.28 5.74 5.04 5,17 3.45 4.76 4.85 5.63 4,91 4.90 5.34

4.44 3.70 4.10 3.67 3.80 4,59 4.09 3.79 4.13 4.42 3.00 3.99 3.94 4.08 3.41 3.84 3.69

1.02 1.24

.81

.97 1.74 1.67 1.86 1.66 1.24

6,33 7.02

4.26 5.73 6.72 6.76 7.09 6.54 6.67

34.6 29.5 28.5 28.7

33.2 44.0 27.4 56.9

Mean 4.77 3,79 1.23 6,15 36.65 4.97 3.92 1.36 6.35 35.35

SE (95%) ±.276 ±.191 ±.300 ±,646 ±5.368 ±.297 ±.191 ±.300 ±,669 ±8,560

<.01 <.05 <.20 <.05 <.60

* See Text for Definition

TABLE. 23

URINE CHEMISTRY SUVIMARY Excretion/24-48 Hours

SUBJECT 1

Day of Study Creatinine Sodium Potassium Chloride Calcium (mgm) (meq) (meq) (meq) (meq)

Ic 1708 115.3 45.7 145.6 13.7 20 1553 67.6 54.4 86.5 13.8 3C 1643 81.1 59.2 85,8 14.2

-40 1844 84.5 60.2 98.4 16.1 50 1573 39.0 '46.4 46,6 16.460 2035 38,2 63.3 .52.7 17.6

7-80 3869 147.8 109.5 171.0 31.9 9-100 3634 197.8 98.9 190.3 32.2

l11 1719 130.5 57.2 129,2 14.0 120 1775 83.6 63.2 95.3 12.5

13-140 4057 138.7 129i7 157.8 13.2

1B 1881 168.0 73.9 -149.5 15.3 2B 1995 122.0 65.0 -139.7 J5.6 3B 3295 97.1 65.2 88.5 17.0-

4B 1784 81.7 68.4 95.5 16.4 5B 1582 73.7 64.5 75.1 15.0 6B 2329 75.3 72.5 85.2 21.6

7-8B 3863 197.4 127.5 188.3 35.6 9-10B 3972 209.7 138.1 204.1 41.3

13B 2002 110.5 66.8 101.3 -18.6 14B 1922 97.2 66.4 -104.7 18.3

15-16B 3601 192.3 145.9 178.9 36.2 17-18B 3729 194.8 114.8 189.8 43.3 19-20B 4116 204,3 127.0 203.7 43.1

21B 1920 82,4 66.4 89.7 23.0 22-23B 4148 183.8 157.0 204.7 44.5 24-25B 4154 203.0 145.2 198.7 51.6 26-27B 4024 206.8 130.0 93.0 45.2

28B 1888 lO0O 69.4 101.7 23.4

IR 2001- 52.0 61.3 66.4 17.2

2R 1993 92.4 57.8 73.8 15.03R 1957 55.4 56,2 65.1 16.8 4R 1961 113.5 67,5 106.3 11.7 R 1812 58.1 47.0 76.9 13.06R 1925 84.0 58.1 84.5 12.4

7R 1948 140.5 60.3 133,9. 8.2 8-9K 3908 137.6 113.0 146.2 23.3

10-11R 3864 136.6 122.0 146.1 19.9 12-13R 3741 112.5 99.1 112.3 17.5

14R 1963 88.8 57.8 63.8 10.0

64

TABLE23

URINE CHENI STRY SUNMARY Excretion/24-48 Hours

SUBJECT 2

Day of Study Creatinine- Sodium Potassium Chloride Calcium (mgm) (meq) (meq) (meq) (meq)

1C 1308 83.6 56.7 105.8 14.2 2C 1295 59.9 46.3 82.3 15.6 -3C -1067 50.4- 45.9 495.4 14.0 4C 1577 105.3 54.6 102.0 15.5 -5C 1637 68.3 '57.3 81.1 15.8.

- -60 931 39.2 42.7 74.0 15.2-7-8C 3307 199.6 110.9 198.6 28.3 -

9-IOC 2455. 177.3 103.4 198.7 27.8 11C 1607 107.5 63.4 \i04.9- 14.5 12C 1877 123.8 67.8 114.7 14.5

13-14C 3277 148.2 122.2 163.8 25.1

B 1795 163.0 61.5 149.9 15.8 2B 1765 83.6 59.1 95.5 13.8 3B 1662 102.6 61.1 86.3 15.6 4B 1656 95.9 61.4 163.9 14.9 -5B 1330 84.4 60.7 91.0 14.1 6B 2538 104.1 79.7 99.3 l8.8

7-8B- 3668 224.4 138.9 221.1 34.8: 9-10B 3588 205.1 139.3 153.7 34.7

13B 1757 104.3 72.2 95.8 16.0 14B 1628 -87.5 65.9 88.7 14.6

15-16B 3778 172.6 121.3- 164.4 - 39.7 17-18B .3519 217.3 131.1 230.0 39.1. 19-20B 3442 205.7 129.4 204.3 35.0

21B 1716 55.7 62.9 76.6 16.0 -22-23B o3155 186.7 124.5 181.3 32.9 24-25B 3246 203.1 129.6 195.4 26-27B 3024 213.9 129.3 210.4 31.7

28B 1484 86.6 62.5 78.4 16.0

IR 1297 25.3 32.2 26.5 9.2 2R 1494 79.4 53.0 73.4 12.9 i 3R 2060 71.7 65.4 83.7- 14.1; 4R 1794 174.3 71.7 169.1 14.6 5R 1626 83.6 43.7 92.4 11.0 6R 1689 96.5 58.0 94.4 11.3 7R 1521 83.7 67.5 102.1- 11.0

8-9R 2760 152..8 127.3 -155.8. 20.210-11R 3091 145.8 100.8 160.8 19.0 12-13K 3218 162.7 112.8 183.8 19.3

1317 74.8 44.1 85.7 40.0

TABLE 23

URINE CHEmISTRY SUiIM Excretion/24-48 Hours

SUBJECT 3

Day of Study Creatinihe Sodium Potassium Chloride Calcium (mgm) (meq) (meq) (meq) (meq)

IC 2219 121.8 68.1 116.7 11.4 2C 1775 68.5 59.6 78.6 10.3 3C 1781 48.7 43.6 53.0 9.3 4C 1580 94.9 64.4 105.4 8.5 5C 1369 -73.7 -48.1 93.0 10.2 6C 1293 93.3 49.7 123.4 9.7 7C 1913 -86.5 51.1 93.7 8.3:

8-9C 3110 173.2 112.2 157.0 18.2 10-11C 3721 166.6 120.3 175o0 19.5

12C 1547 99.2 55.6 i04.2 9.7 130 1688 107.0 54.5 106.0 10.7

14-15C 3785 192.9 122.7 :162o8 21.4

IB 1793 136.6 57.9 ,103.8o 11.6 2B 1777 89.7 60,2 91.1 10.0 3B 1246 70.7 46.5 102.4 11.9 4B 1704 78.4 59.3 84.6 10.0 5B 1947 90.6 67.0 91.0 11.3 6B 1802 108.9 62.4 99.4 12.0

7-8B 3562 197.2 112.6 194.9 26.4 9-10B 3016 148.5 109.8 185.3 25.2

13B 1401 78.6 52.0 i00.0 13.5. 14B 1358 65-.9 46.6 86.1 12.9

-15-16B 3722 170.0 114.0 189.0 29.3 17-18B 3493- 189.5 115.5 210.2 30.0 19-20B 3317 174.3 108.0 1-89.2 28.7

21B 1721 80.7 58.8 83.1 13.2 22B 1s18 72.5 49.3 106.3 14.7

23-24B 2932 144.6 92.1 194.2 28.7 25-26B 3507 180.6 118,7 168.1 24.7

27B 1420 64.8 54.0 81o0 12.7 28B 1692 88.9 67.5 89.6 13.4

IR 1586 25.9 47.7 48,6 10.6'

2R 1679 47.6 48.5 49.1 10.4 3R 1935 76.4 68,4 t8.9 10.5 4R 1702 111.2 68.8' 114.2 9.9 5R 1141 64.2 43.0 93.6 9.9 6R 1696 68.3 43.6 78.0 10.5

7-8R 2181 1M8.5 68.7 131.7 13.2 9-10R 3323 217.7 100.2 171.6 17.4 11-12R 2553 198.6 96.3 234.9 16.2

13R 1346 90.0 50.8 115.0 7.6 14R 1653 80.2- 60.8 97.0 7.7

TABLE 23

URINE -CHEMISTRY SUhARY Excretion/24-48 Hours

SUBJECT 4


1C 1846 126,6 63,4 130,8 7.0 2C 2040 53.3 83.1 74.3 4.7 3C 1552 61.8 57.1 82.1 5.7 4C 1990 98.3 70.8 96.9 6.0 50 1252 47.6- 41.3 84.4 4.1 6C 2040 106.5 - 59.1 103.7 5.6

?-8C 3994 221.2 121.0 197.9 11.4 9-10C 3229 162.1 96.4 178.2 13.2

11 1156 82.8" 49.9 1,16.2 6.2 12C 1399 48.5 47.1 .72.1 5.4

13-14c 3318 168.6 117.5 173.5 10.6

1B 1401 150.0 51.9 179.3 9.0 2B 1736 -97.6 55,6 -93.8 6.6 3B 1974 104.5 74.0 -92.4 7.4 4B 1707 78.5 59.4 77.9 7.6 5B 1505 95.6 62.5 111.7 9.7 6B 2046 85.4 71.6 62.7 7.6

7-8B 3517 206.2 127.1 217.1 18.4 9-10B 3558 169.1 120.8 182,4 17.4

11-12B 3047 194.3 111.2 198.1 19.1 13B- 2126 73.2 64.4 88.7 8.7 14B 1500 106.6 61.9 119.3 9.2

15-16B 3379 159.2 127.7 161.3 18,1 17-18B 3808 204.9 140.0 215.6 19.7 19-20B -3995 211.8 134.1 205.4 18.2

21B 1139 73.9 50.9 92.1- _-8.6 22B 1774 93.4 65.0 94,0 8.3

23-24B 3926 172.9 138.6 200.2 18.1 25-26B 4090 208.0 125.1 207.5 17.7

27B 1973 139.5 67.5 137.6 9.7 28B 1459 61.6 57.4 75.3 7.2

IR 1905 18.4 66.1 24.8 -5.1 2R 1870 -24.0 57.1 45.2 6.0 ,' 3R 2110 45.5 53.7 48.8 6.0 4R 1903 61.5 54.1 63.5 4.4 5R '1735 124.5 49.5 117.0 6.7 6R 2051' 129.2 50,1 131.7 5.6 7R 1984 93.6 51.3- 110.0 4.6 8R. 1951 126.4 50.5 115.9 4.8

9-10R 204.2 104.2 189.8 10.8 11-12R 4051 200.0 115.0 207.1 10.6

13R 1372 71.6 40.2 99.3 .5.4

14R 1638 92.6 44.6 105.7 4.7

TABUE 23

URINE CHEMIfSTRY SUMMARY Excretion/24-48 Hours

SUBJECT 5

Day of Study Creatinine Sodium Potassium Chloride Calcium

(mgm) (meq) (meq) (meq) (meq)

1C 1417 140.4 52.1 130.2 9.7 2C 868 134.6 37.6 158.4 9.3 3C 1266 142.9 54.6 165.0 10.2 4C 1141 126.7 65.1 139.0 7.1 5C 1535 125.5 61.2 129.0 8.5 6C 1343 125.1 - 58.0 135.0 9.1

7-8C 2227 268.2 94.6 334.5 20.5 9C 1277 141.2 43.8 122.1 9.8

10C 1254 134.1 59.5 i58.1 9.1 -11-12C. 2956 307.0 127.5 312.2 18.3 13-14C 2688 320.7 121.3 340.3 19.7

IB 1561 171.9 55.5 161.0 11.1 2B 1040 142.1 55.6 189.4 9.9 3B- 1452 168.1 64.8 178.6 11.7 4B 1367 158.4 61.8 158.6 12.0 5B 1600 151.6 72.6 157.5 10.4 6B 1114 132.9 57.2 162.0 11.6

7-8B 2925 311.5 151.5 315.2 22.8 9-10B 3030 308.8 113.3 332.7 25.9

11-12B 3237 348.1 108.1 362.5 26.6 13B 1595 154.9 62.7 158.1 14.6 14B 1446 153.0 65.6 13.9 15B 1720 169.5 66.3 173.3 14.9 16B 1373 143.2 69.3 151.7 11.7

17-18B 2895 291.8 135.1 316.9 27.3. 19-20B 3053 307.2 134.4 328,7 - 28.9 23-24B 2702 328.3 125.6 373.4 30.3 25-26B 3149 316.7 145.7 331.5 .27.7

27B 1609 167.2 75.7 168.7 15.1 28B 1218 147.3 67.1 155.3 11.9

IR 1524 109.7 44.5 119.7 13.8 2R 1351 79.0 37.1 99.1 12.9 3R 1525 187.2 60.4 180.0 13.3, 4R 1494 131.9 53.4 143.1 10.21 5R 1314 168.8 66.7 164.6 10.7 6R 1346 121.5 57.1 142.3 9.0 7R 1313 191.4 66.0 209.0 10.2 8R 1466 130.8 54.3 147.8, 9.3

9-1OR 2494 284.4 121.7 323.8 17.7 11-12R 3062 350.0 146.2 357.2 17.9

13R 1475 170.9 66.8 166.0 8.9 14R 1278 133.6 57.6 153.5 6.9

68

TABLE 23

URINE CHEMn5tY.SUMARY Excretion/24-48 Hours'

SUBJECT 6

Day of Study Creatinine Sodium PotaagpLum Chloride Calcium (mgm) (meq) (ner$ (meq) (meq)

10 20 30

1605 1170 1163

163.1 84.6 112.5

6C 6 46'-7 66 .A

166.2, 96.5 132.5

23.0 14.7 17.6

40 -50-60

754 1171 526

55.9 102.6 56.8

3 ,' 48'7

-2.*

79.9 120.0 19.9

14.8 22.1. 15.

-80 90

10C

1842 1339 1181

216.9 131.4 141.4

8*.7 5,> 5-

286.4 131.5 137.9

41.7 23.5' 19.8

11-120 3105 217.2 222.7 40.513-14C 3203 270.3 i.,7 281.3 39.4

lB 2B 3B

1460 1073 1553

183,3 116.7 174.5

5t.7 6,-,9

184.8 128,8 14179.5

24.7 25.7 26.1

4B 5B

1152 1541

-102.2 146.3

, 144,0 460.2

28.7 29.6

6B 1402 120.9 7.2 i142.3 22.6 7-8B

9-10B 11-12B

13B

2950 3330 3297 1045

292.4 295.8 296.4 116.2

1A>7 It,5 Iz,

336.5 330.9 301,8 125.7

56.9 60.7 62.427.9

14B 1387 143.6 - £C,5 168.7 35.2 15B 16B

1558 1138

167.2 103,4

,4 5A.i

141.3 128.5

31.3 24.3

19-20B 2i-22B

2641 3332

245.1 305.3

1P,,3IS,6

317.6 290.8

61.3 58.7

23-24B

25-26B 27B 28B

3336

3046 1488 1584

298.5

286,5 117.8 129.9

I7,0

1 40,0 7.7

g ,7

326.7

283,6 129.9 164.4

59,.4 '57.2 '25.-S. 26.7

IR 2R

1509 1368

72,2 125.0

f1.2 13.2

81.7 131.7 -

24.0 21.0

3R" 1159 73.4 50.9 '77.1 20.5 4R 5R

1450 1636.

168.3 168.0

b2,0 51.8

171.7 178.6

24.5 20.9

6R 1737 184.8 66.8 182.4 23.1f 7R 1422 120.1 5ft.6 152.7- i9.2 8R

9-10R 11-12R

13R

1472 3323 3483 1142

82.2 288.9 357.4 82.7

8 i6.O j.14.9 45.7

-2 92.7 273.2 314.7 67.1

16.8 37.9 39.2 14.4

1 1369 155.2 0.5 160.1 25.0

69

<TABLE 23

URINE CHEMISTRY SUMiARY Excretion/24-48 Hours

SUBJECT 7

Day of Stud) Creatinine Sodium Potassium (Ingm) (meq) (meq)

1C 1371 115.5 2C 1460 147.3 3 1531 195.9 4C 1213 104.4 5C 1414 155.7 60 1319 83.8 9C 945 156o7 10C 1310 128.7

li-120 3122 339.4 13C 1290 131.4 14C 1580 111.7

1B 1490 172.2

2B 1428 161,0 3B 1081 139.6 4B 1559 159.6 5B 1515 147,4 6B 1474 135.4

7-SB 2807 322.9 9-10B 3143 336.7 II-12B 2987 311.1

.13B 1516 145,9 14B 1519 136.9

15-16B 2522 205.7 17-18B 2890 -319.9 19-20B 2730 293.7 25-26B 3008 274.4

27B 1484 162.7 28B 1419 125.4

IR 1381 76.6 2R 826 106.5 3R 1502 143.8 4R 1587 233.6 5R 1590 172.2 6R 1524 136.2 7R 1621 119.9 8R 1579 152.5

9-IR 2945 320.0 1I12R 2962 272.1

13R 1401 101.0 AR 1472 154.7

1hloride Calcium

(neq) (meq)

123.3 7.0 143.1 9.7 187.8 9.1 122.0 8.5 160.8 9.8 133.0 8.7 171.0 17.0 102.9 8.2 229.1 18.4 144.4 7.9 82,6 7.6

168.6 9.0

157.7 8.2 153.6 9.7 160.5 8.0 152.4 8.1 136.1 9.5 319.9 18.6 328.2 20.0 30-2.2 21.2 153,8 10.8 134,4 10.5

193.5 -24.2 329.2 23.3 258.2 24.5 264,' -23.0

153.4 12"1 137.4 11.4,

84.8 11.2 91.3 8.0

141.5 9.2 213.9 :11.2 159.3 19.9 130.9 . 9.4 143.2 10.3 121.7 8.7 290.3 17.9 294.9 15.6" 102,3 6.3 147.4 8,4

20

TABLE 23

URINE CHEMISTRY SUMMARY Excretion/24-48 Hours

SUBJECT 8


1C 1474 135.0 36.6 169 O 2C 1793 126.1 51.1 143o4 13.2 3C 1851 141.4 48.6 145.9 12.2 4C 1860 159.4 63.1 163.6 12.6 5C .1825 148.8 52.9 138.5 13.5 6C 1810 110.9 - 51.0 120.0 11.5 .9C- 1464 146,6 54.9 135.5 15.7 10C 1576 75.9 53°3 105.3 12.7

11-12C 3032 237.1 91.6 '258.5 24.7 13C 1829 158.2 63.6 158.5 14.2 14C 1594 170.2 56.1 159.1 13.2

1B 1546 176.1 44.0 159.6 15.0 2B i694 177.6 56.1 -186.2 15.0 3B 1865 122.7 156.6 126.9 16.4 4B 2022 180.5 64,2 134.1 20.0 5B 2143 177.6 86.5 176.1 17.4 6B 1969 152,9 50.3 137.1 15.1

7-8B 3504 327.1 192.6 350.8 37.3 9-10B 3873 311.4 115.9 Z96.5 33.7

13B 1771 150.8 60.3 156.6 18.0 14B 1621 127.5 59.8 136.4 18.5

15-16B 3209 325°6 125.0 339.1 31.7 17-18B 3817 331.0 128.6 309.2 40.0 19-20B 3848 -333°6 126.1 310.8 39.7 21-22B 3561 300,2 111.7 303.3 41.2 25-26B 3985 327.4 122.8 312.6 40.0

IR 2081 73.3 57.8 65.0 15.0 2R 1773 68.7 42.1 83.1 14.8 3R 1887 164.0 47.2 163.7 16.4 4R 1920 158.4 56.1 148.6 15.0 5R 2126 145.9 70.8 169.2 14.6 6R 965 62.9 29.7 79.7 13.1 7R .1929 174.0 58.4 183.0 22.7 8R 1774 148.3 51.4 162.2 14.5

9-10R 3239 175.4 86.8 206.4 26.2 11-12R 3808 347°2 106.3 336.7 24.9

13R 2158 110o3 46.0 125.0 9.3[4R 1723 -195.8 - 62.1 165.9. 12.9

--7

TABLE 23

URINE CHEmiSTRY SUIMARY Excretion/24-48 Hours

SUBJECT 9


IC 1713 172.7 62.4 171.8 6.9 20 1708 140.0 60.1 152.5 6.7 3C 1786 136.8 58.0 154.9 7.4 4C 1846 155.9 61.4 165.3 7.0 5C 1886 155.0 60.4 i61.5 7.6 6C 1685 112.5 .47.9 119.4 6.3

7-8C 3448 344.8 104.5 372.6 14.8 9C 1489 167.6 51.6 169.3 6.6

10C 1751 145,6 61.9 162.5 7.1 11-120 3456 305.2 116.6 318.7 14.2

13C 1816 150.4 56.9 162.8 6.8 14C 1734 169.8 56.4 166.5 8.4

IB 1657 181.9 .54.2 168.8 8.6 2B 1613 169.8 60.0 174.7 7.5 3B 1766 176.6 70.1 178.5 8.0 4B 1726 148.8 57.2 152.2 7.3 5B 1736 154.0 53.7 149.8 7.4 6B 1786 146.0 53.1 152.6 9.5:

7-8B 3631 320.5 126.3 319.0 16.0 9-10B 3497 302.4 129.8 312.3 16.2 11-12B 3650 344.2 130.5 354.2 10.0

13B 1696 159.2 59.2 153.3 8.0 14B 1538 139.6 49.8 141.6 7.7

15-16B 3546 337.7 118.0 348.9 16.3 17-18B 3486 337.4 140.2 333.7 16.7 19-20B 3565 347.7 125.5 365.3 -17.0 21-22B 3553 327,8 128.0 333.1 17.2 23-24B 3452 357.1 119.8 360.8 -16.4 25-26B 3536 347.5 118.4 364.3 18.6'

27B 1763 162.7 67.4 165.7 8.1 28B 1782 137.3 68.6 149.2 8.3

IR 1840 117.4 62.9 125.7 8.8 2R 1713 94.3 62.2 111.5 74 3R 1781 146o3 63.0 156.6 7.7.. 4R 1779 153.6 55.3 157.0 6.7 5R 1738 159.6 42.5 170.6 7.5 6R 1431 141.7 39.8 146.9 6.11 7R .1690 216.8 57.0 223,8 7,9 8R 1709 -181.4 56.7 180.1 7.8

9-10R 3462 292.1 120.5 315.7 13.2 11-12R 3434 343.4 102.8 355.1 15.4

13R 1752 202.9 71.7 207.2 '6.1 14R 1771 155.7- 60.3 157.8 6.3

TABLE 22

URINTE CHENISTRY SUfrMA Excretion/24-48 Hours

SUBJECT 10


IC 2240 160.1 76.0 177.6 11.2 3C 2174 152.7 74.0 162.4 11.3 4C 2144 139.2 63.0 155.4 11.9 5C 2128 146.1 61.9 158.8 13.0 6C 2115 167.0 68.3 179.4 13.6

7-8C 4097 327.6 131.6 349.1 27.8 9C 2087 168.7 65.2 173.8 14.8

10C 1595 111.9 54°4 105.8 12.8 11-12C 3911 285.3 149.3 318.1 23.8

13C 2159 144.6 72.3 173.0 12.0 14C 2048 124.3 62.4 129.7 11.4

IB 2129 248.0 74.1 '251.5 16.9 2B 1725 121.3 50.4 137.0 14.0 3B 2096 144.4 73.4 -162.5 15.2 4B 2155 132.7 72.8 153.8 15.4 5B 2136 155.6 62.5 161.8 15.7 6B 1897 153.2 71.0 153.2 14.8

7-8B 4336 306.2 144.8 327.1 33.7 -9-10B 3825 288.6 149.3 296.9 32.5 11-12B 4274 308.8 154.4 343.6 33.4

13B 2185 178.4 79.0 174.8 17.5 14B 1960 123.7 71.6 139.0 17.6

15-16B 4365 320.1 141.1 337.5 35.5 17-18B 4241 324.4 141.1 332.2 35.4 19-203 4184 306.3 157.3 304.2 -36.6 21-22B 3844 297.0 133.0 309.8 34.4 23-24B 4118 353.0 142.2 .351.8 35.4 25-26B 4289 302o1 148.3 317.9 34.4

27B 2054 159.1 71.5 165.4 18.9 28B 2171 141.9 78.2 159.8 17.5

IR 2192 10,0.6 72.0 116.6 13,.5 2R 2031 101.5 67.4 120.7 120 3R 2133 199.0 73.9 200.7 12.9 4R 2184 217.5 72.1 213.1 14.2" 5R 2093 185.7 56.1 184.3 15.6 6R 2062 115.9 52.7 130.3 13'I1. 7R 2301 100.4 72.7 175.8 13.3 8R 2234 146.8 65.1 162.6 12.2

9-10R 4223 334.5 169.9 359.6 24.8 11-12R 4241 275.9 135.9 297.8 24.2

13R 2115 147.7 73.1 168.5 9.7 14R 2153 170.3 67.1 174.1 11.3

TABLE 23

URINE CHEMISTRY SUiMAR) Excretion/24-48 Hours

SUBJECT 11



Ic 1687 138.0 71.5 146.2 12.8 2C 1886 114.0 73.5 112.9 13.4 3C 1795 151.0 81.7 154.7 14.1 4C 1808 157.9 83.0- 156.6 14.1 5C 1780 174.8 93.3 178.2 14.8 6C -1758 126.2 70.9 133.0 14.2

1-8C 3567 341.3 166.8 363.1 27.8 9C 1814 122.6 71.4 131.9 12.7

1OC 1671 142.4 80.3 153.8 -12.6 13C 1705 147.2 66.9 153.4 14.8 14C 1660 134o3 62.1 136.8

IB 1729 211.8 85.1 -195.3 16.9 2B 1732 148.4 77.7 -152.9 16.4 3B 1739 168.0 81.6 168.8 8.5 4B 1747 153.2 77.8 J58o9 18.1 5B 1781 153.2 73.9 152.1 19.3 6B 1758 152.2 80.3 161.6 18.6

-8B 3305 350.2 155.7 333.4 38.0-9-10B 3430 324.3 155.7 316.5 37.8 11-12B 3513 335.4 163.4 324.8 38.6

13B 1908 140.9 75.2 142.7 19.1 14B 1789 153.6 76.1 153.1 19.6

15-16B 3511 .342.6 164.2 330.2 37.7 17-18B 3653 344.8 153.3 336.5 36.9 19-20B 3501 319.3 158.9 307.7 36.2 21-22B 3517 346.3 158.0 325.0 37.7 23-24B 2817 304.9 131.2 264.8 36.5 25-26B 2959 277.8 132.0 256.8 32.9

27B 1676 148.6 76.7 157.0 16.5 28B 1599 159.0 66.8 158.6 16.6

IR 1727 119.2 73.4 121.3 17.6 2R 1792 103.2 73.5 94°5 14,1 3R 1694 177.5 80.8 175.4 151 4R 1618 182.3 71.9 163.1 14.0 5R 1545 178.2 78.0 176.2 -154 6R 1633 169.3 75.2 157.1 14.5 7R 1511 117.5 62.7 118.3 12.2 8R 1564 142.6 65.5 133.5 13.3

9-I0R 2609 269.6 127.6 241.8 26.8 1-12R 3314 338.1 138.1 329.7 27.9

13R 1619 145.7 5903 129.9 12.6 14R 1518 130.4 64.1 122.1 11.3

TABLE 23.

URINE CHENISTRY SUIhRhARY Excretion/24-48 Hours

SUBJECT 12

Day of Study Creatinin Sodium Potassium Chlorid( Calcium (mgm) (meq) (meq) (meq) (meq)

10 1867 148.5 66.9 156.1 11.4 20- 1872 110.5 62-.-5- 122.2 11.4 30 1859 139.6 66.7 145.5 12.6 4C 1821 159.7 57.4 163.8 13.1 50 1781 164.8 56.0 161.7 13.3 6C- 1813 120.2 57i 137.9 13.0

7-80 3412 04.9 i07. 300.4 25.1 90 1718 126.7 53.8 130.2 10.2

100 1677 125.6 '49.4 123.5 11.6 130 1833 179.0 55.3 185.6 14.6 140 1825 128.8 61.8 138.4 -11.5

IB 1618 196.9 -55.2 185.3 13.6 2B 1843 129.8 60.2 147.5 14.0 33 1866 155.5 -66.6 158.3 16.2 4B 1830 152.3 69.0 '158.0 14.9 5B 1893 142.4 59.0 140.0 '15.3 6B 1892 170,5 66.5 176.9 14.9

7-8B 3657 323.1 125.3 336.8 29.7 9-10B 3804 318.8 128.0 325.2 30.3

11-12B 3878 318.3 133.2 318.9 32.1 - 13B 1960 148.9 66.7 160.8 16.0

14B 1885 154.9 62.6 157.3 16.3, 17-18B 3849 318.2 113.6 322.5 33.4 19-20B 3437 296.7 109.6 299.1 33.6 21-22B 3871 312.0 128.3 322.4 33.1 23-24B 3763 326.1 123.7 335.6 33.3 25-26B 3771 266.1 108.9 275.9 31.3

273 1818 158.0 59.2 164.7 17.3 283 1796 137.4 46.8 140.6 16.3

IR 1773 104.0 49.7 119.6 13.9 2R 1847 129.8 53.1 134.3 14.1 3R 1889 142.1 62.9 147.0 14.9 4R 1708 140.5 49.1 145.2 12'9 5R 1430 130.7 41.4 136.6 11. 7 6R 1666 124.4 44.9 132.3 12.-8 .7? 1651 156.6 53.6 159.4. 13.6

- 8R 1689 .113.5 43.0 118.3 12.5 --9-10R 3095 181.0 72.4 189.3- 25.0 11-12R 3588 337.8 97.5 335.7 28.5

13R 1675 124.7 42.6 141.0 10.4 14R 1838 116.2 53.5 120.5 11.0

4a5

TABLE 23

URINE CHEMffSTRY SUMMARY Excretion/24-48 Hours

SUBJECT 13


1C 1796 169.8 50.4- 161.7 8.5 20 1711 200.7 60.6 186.1 8.9 3C 1769 123.7 63.8 138.8. 8.2 -4C 1826 149.4 71.4 156.5 8.5 5C 1672 119.7 -53.4 116.5 7.6: 6C 1820 132.6 68.6- 146.1 9.5

7-8C 3591 292.6 127.7 308.2 19.6 9C 1860 202.1 60.2 191.5 10.5

10C 1781 173.7 63.6 176.9 10.8 11-12C 3612 310.9 123.3 321.1 22.8

13C 1765 138.3 59.7 132.9 8.8 140 1719 152.2 65;0 -155.2 .11.5

IB 1783 131.8 48.5 109.1 10.5 2B 17-38 -174.5 - 77.2 190.9 11.2 3B 1789 171.0 66.5 178.8 11.3 4B 1559 167.1 64.5 161.6 .13.1 -5B 1843 176.1 62.8 175.0 13.2 6B 1731 174.5 62.8 169.5 13.6

-7-8B 3427 330.0 125.7 329.6 263. '9-10B 3924 337.3 129,3 340.3 33.7 (1-12B 3542 326.4 129.6 338.0 29.4 --'.13B 1871 136.7 63.4 135.2 13.9

14B 1804 -185.9 67.6 180.1 14.7 15-16B 3728 255.9 117.8 270.3 22.0 17-18B 3729 372.4 143.6 342.2 26.4 19-20B 3603 265.2 137.3 288.5 26.9" 21-22B 3535 293.5 148.5 299.6 27.0 23-24B 3704 375.3 140.4 364.8 30.1 25-26B 3650 278.8" 150.6 294.0 29.0

27B 1639 176.1 67.0 169.4 14.3 28B 1914 159.5 69.3 168.6 15.0

IR -1566 71.4 41.4 ,95,2 12Z4 2R 1405 47.3 39.2 53.8 7.9-1 3R 1562 77.0 43.8 82.6 10.5 4R 2000 122o9 48.6 125.2 15.6 5R 1915 164.5 66.5 175.2 9.9 6R 1770 201.4 74.0 174.6 11.2 7R 1936 176.0 65.1 177.6 9.8 8R 1772 100.8 34.1 110.3 10.3

9-10R 3622 230.4 95.7 259.1 15.6 11-12R 3677 325.0 113.9 312.8 15.6

13R 1710 111:7 55.4 105.8 5.8 14R 1371 144.4 CL A 120.7 5.3

'76

TABLE 23

URINE CHEMISTRY SUMJMARY Excretion/24-48 Hours

SUBJECT 14

Day of Study Creatinine Sodium Potassium Chloride Calcium (mgm)- (meq) (meq) (meq) (meq)

10 1545 133.1 44.2 126.9 9.3 20 2004 241.2 85.7 217.5 13.4 3C 1742 137.0 67.7 146.2 9.7 4C 2018 156.8 78.4 161.3 10.4 5C 1955 154.5 47.4 134.3 10.9 6C 1838 107.4 54,4 125.2 12.5

7-8G 3663 348.5 138.0 360.5 24.0 9C 2031 187.5 57.7 148.9 13.1 10C 1705 177.4 60.6 173.3 13.9

11-12C 3751 282.5 115.2 271.8 24,9 13C 1859 150.0 53.5 135.0 13.5 14C 1706 150.7 69.4 159M8 10.7

1B 1944 233.2 62.4 i90.4 15.3 2B 1841 183.7 73.8 188.0 12.7 3B 1915 214.0 67.9 203,5 15.5 4B 1839 169.0 63,7 165.7 14.6 5B 1906 206.6 69.9 186.3 15.0 6B 1782 174.8 59,3 168.6 16.7

7-8B 3756 332.8 135,0 S29..2 32.5 9-10B 3937 384.4 136.4 381.6 35.6 11-12B 3775 289.8 136.7 284.1 34.7

13B 1703 117.7 65.1 113.1 14.8 14B 2001 252.1 69.9 244.3 18.9

15-16B 3664 401.5 116.8 366.4 28;4 17-18B 3772 374.4 -169.6 349.5 28.1 19-20B 3740 250.0 137.5 231.1 33.1 21-22B 4116 295.0 149.6 292.9 40.4 23-24B 3943 381.6 140.4 353.7 41.0 25-26B 3887 321.3 151.2 319.3 42.3

27B 1878 171.1 63.1 156.9 19.1 28B 1800 155.1 55.4 140.8 20.2

IR 1952 88.3 72.6 108.6 17.0 2R 1634 97.0 41.2 84.2 12-,8 3R 2048 99.3 56.0 103.8 13.8 4R- 1873 204.3 59.0 167.3 1.8' 5R 2016 201.9 72,4 207.0 12.8 6R 1880 198.4 55.5 173.0 .10.9

7R 1907 147,8 65.9 148.9 12.2 8R 1742 92.0 33,6 75.8 10,4

9-10R 3410 392.4 125.4 365.4 23.1 11-12R 3536 297.2 143.8 311.4 16.9

13R 1806 157.9 79.2 139.1 8.8 14R 11,9 105.4 7305 99°4 9.1

-tAfE 23.

URINE CIEUSTRY SUMMARY Excretion/24-48 Hours

SUBJECT 15

--ay of Study- -Crdatinine Sodium Potassium Chloride. Calcium(mgm) (meq) (meq) (meq) (meq)

1C 1644 192.9 65.0 186.0 10.4 20 1731 113.2 68.9 131.4 9.8 30 1313 118.4 40.7 107.6 9.0 40 1801 119.9 58.4. 423.4 -9.3. 50 1323 111.6 136.4 87.0 7.1

--60 1771 56;4 50.8 71.6 9.8

7-80 2635 205.4 81.4 182.1 16.2 -

90 1582 146.4 59.5 149.1 10.0 10C 1720 131.0 58.2 126.5 10.9

_11-120 2947 218.4 71.7 204.3 20M2 13C 1469 68.6 46.6 75.1 6.5 140 1359 83.2 35.8 81.1 7.3

IB 2007 194.6 55.6 158.8 13.5 2B 1835 191.2 50.3- 187.2 15.8 3B 1824 205.8 65.7 199.4 18.2 4B 1897 174.5 58.2 174.2 15.2 5B 1956 127.1 62.4 128.9 15.2 6B 1946 114.0 62.7 119.2 15.6

- 7-8B- 3797 335.6 118.1 310.8 35.7 9-10B 3701 275.1 121.1 257.0 30.1

11-12B- 3766 .361.5 141.2 352.8 33.3 13B 1952 129.5 59.3 134.1 18.5 14B - 1863 128.3 46.7 126.0 19.2

15-16B - 3733 263.1 123.5 260.1 38.1 17-18B 3760 329.4 .115.3 319.5 :40.1 19-20B 3674 350.0 127.9 335.0 37.6 21;22B 3786 321.9 131.9 15.6 -37.9 23-24B 3877 326.7 149.9 310.8 36.1 25-26B 3808 347.1 121.3 324.1 40.3

27B 1903 136.2 67.2 140.7 18.9 28B 1878 164.4 70.0 160.0 19.8

IR 1388 28.6 40.3 41.9 1026 "2R 1877 44.6 47.6 48.0- 13. , 3R 1689 59.9 34.8 53.2 12.7 4R 1490 -138.0 18.4 86.8 12.0 5R 1522 182.2 37.5 157.9 12.5 6R- 1811 ullO9 64.4- -138.5 10.4 7R 1675 119.3 60.9 118.0 9.9 8R 1449 52.7 27.4 56.9 6.8

9-IR - 3699 155.8 90.2 144.5 17.3

TABLE 23'

URINE CHEMISTRY SUMMARY

Excretion/24-48 Hours

SUBJECT 16



1C 1557 140.6 69.0 148.3 14.0 2C 1692 114.4 63.5 114.2 13.6 3C 1589 114.6 64.4 115.4 11.0 '4C 1661 152.1 73.1 138.9 12.9 -5C 1748 169.3 74.4 161.4 14.0 6C 1647 113.1 62.1. 117.1" 13.1

-7-8C 3073 209.5 122.9 218.9 26.2 9C 1786 187.1 71.1 179.8 17.9

10C 1753 89.1 63.4 94.6 15.0 11-12C 3176 222.8 99.8 208.6 25.3

13C i948 92.7 75.5 i03.8 14.6 140 1485 96.4 59.4 90.2 11.8

IB 2152 283.3 76.8 264.6 18.9 2B 1959 157.5 75.0 156.1- 17.7 3B 1593 115.9 78.7 121.1* 16.3 4B 2286 134.3 87.1 133.0 20.7 5- 1938 126.7 78.5 133.0 20.5 6B 2053 204.1 85.0 193.2 23.5

7-8B 3905 361.2 154.6 343.6 46.6 910B 4066 242.5 156,7 239.3 30.8

-11-12B 4122 323.5 168.8 317.3- 40.6 [3B 1702 133.6 63.6 128.5 22.0 14B 2288 174.4 94.0 175.9 24.9

15-16B 4129 303.7 171.8 297.9 47.917-18B 3985 308.1 170.4 301.9 48.9-19-20B 3978 259.4 164.6 260.6 48.721-22B 3986 328.2 175.5 334.1 47.6' 23-24B 3895 298.7 169.7 284.1 47.6 25-26B 4540 346.7 179.4 338.9 58.8

M7B 1952 154.1 74.7 153.6 24.8 8B 1980 185.2 80.5 177.8 25.5

iR 1714 69.4 64.2 76.1 18.8 2R 1835 140.7 62.1 119.4 18.1 3R 1744 -126.5 55.0 114.7., 17.5: 4R 2072 173,8 60.0 151.5 21.1 5R 1664 144.6 59.1 133.9 14.0 6R .1403 104.1 62.9 112.6- 10.67P 1895 160.6 77.2 148,V 14.3 8R 1773 148,3 79°8 149.9 12.9

9-OR 3209 273.9 115 6 267o9 21.2 .11-12R 3691 366.8 134.0 343.2- 27.5

L3R 1877 164o0 83.8 164.8 13.0 L4R 1822 131.2 67.6 121.8 11.3

79

TABLE 23

URINE CHEISTRY SUNMARY Excretion/24-48 Hours

SUBJECT 17


1C 1558 148.4 71.5 161.8 11.5 2C 1381, 160.4 63.6 161.7 10.8 3C 1349' 174.9 67.6 172.2 11.2 4C 1583 145.1 74.5 157.0 11.8 5C 1467 173.2 73.2 182.1 11,0 60 1498 150.4 68.8 160.3 10.4

7-8C 2840 335.8 154,6 360.7 24.1 9C 1465 162.2 -80.3 170.4 11.3

10C 1447 161.2 75.5 165.0 11.8 11-12C 2731 265.8 140.5 272.1 16.9

13C 1566 163.1 67.2 170.2 13.2 140 1508 172.3 68.3 174.2 11.7

IB 1579 196.2 79.8 201.3 13.3 2B 1682 215.4 80.3 221.7 13.5 3B 1553 193.8 68.6 '192.0 13.6 4B 1553 168.5 79.9 181.2 13,1 5B 1548 146.5 72.5 143.7 12,7 6B 1549 178.7 93.2 i86.1 11.8

7-8B 3241 387.3 157.2 363.7 26,0 9-10B 3254 370.0 164.4 364.8 25.6 11-12B 3318 347.8 173.9 340.3 23.3

13B 1638 128.3 98.7 141.8 12.3 14B 1614 165.3 80.0 170.7 11.7

15-16B 2808 339.4 147.8 326.5 22.5 17-18B 3376 344,2 163.9 351.4 25.1 19-20B 3315 347.6 175.8 353.2 49.3. 21-22B 2985 304.2 134.4 310.1 34.A 23-24B 3351 350.6 169.5 352.3 25.8 25-26B 3316 352.6 158.3 339.3 25.1

27B 1622 184.6 100.7 197.2 13.0 28B 1467 157.7 72.9 162.1 10.8

IR 1335 80,8 67.9 81.4 8.4 2R 1615 132.5 84,5 145.1 9.7 3R 1644 170.3 72.2 166.3 9.3 5R 1675 180.8 70.6 166.8 9.5 6R 1534 166.6 75.6 161.3 10.0 7R 1652 149.7 81.5 153.8 10.01 8R 1651 151.3 - 78.5 152.4 10,6

4'.9--OR 3258 337.1 .144.5 337.6 199.II-.12R 3197. 385.6 147.8 375.8 20.4

13R 1638 134.7 79.2 145.7 10.4 14R 1630 154.7 87.9 166.6 10.5.

,-So

* SUBJECT 18


(mgm) .(meq) (meq) (meq) (meq)

10 1767 164.4 76.6 169.9 5.6 2C 1691 154.8 71.4 160.1 6.2 30 1544 85.2 65.7 89.7 4.8 40 1785 139.2 88.3 150.7 6.1 50 1486 122.9 71.0 124.2 5.8 60 1350 118.9 61.0 126.4 4.6

7-8C 3245 258.8 121.0 276.5 10.2. 90 1905 195.3 86.5 203.3 6.6 1OC 1644 148.2 73.3 144.9 5.7

11-120 3407 307.0 142.2 310.0 10.7 140 1843 142.4 63.7 148.6 6.9

1B 1854 185.2 55.4 189.8 7.4 2B 1780 202.7 79.4 214.7 6.6 3B 1948 186.0 79.5 200.0 7.7 4B 1886 137.4 74.0 144.9 5.3 5B 1737 148.4 87.5 169.6 8.6 6B 1866 160.9 78.9 161.8 7.4

7-8B 3602 356.1 172.9 375.7 15.4 9-10B 3735 301.9 170.3 316.7 15.3 11-12B 3816 337.3 175.1 342.1 16.7

13B 1874 148.7 86.2 156.6 8.9 14B 1812 148.9 81.1 154.0 8.7

15-16B 3762 347.3 177.9 357.1 17.9 17-18B 3773 325.4 167.9 333.1 19.4 19-20B 3707 291.3 162.2 303.3 10.2 21-22B 4158 427.0 189.2 440.3 17.4 -23-24B 3676 236.4 180.4 235.8 20.0 25-26B 3673 239.9 151.4 266.7 22.6

27B 1742 144.6 75.5 151.4 11.4 28B -1891 194.4 84.0 192.4 11.1

IR 1749 78.0 53.8 83.8 11.0 2R 1833 78.4 71.9 98.5 10.4 3R. 1979 125'2 83.2 139.1 11.9 4R 1320 99.4 58.7 103.9 4.9 5R 1822 153.1 84.5 156.3 6.7 6R 1820 166.3 77.0 152.1 7 4 7R 1746 130.4 72.2 139.0 6.6 8R 1487 85.3 49.5 85.8 6.6

9-10R 3308 197.0 126.2 220.8 12.7 11-12R 3398 345.5 161.9 351.9 13.5

13R 1570 112.3 66.4 123.6 6-2 14R 1867 135.4 88.6 146.0 6.9

-St

TABLE 23

URINE CHEMISTRY SUIVMARY Excretion/24-48 Hours

SUBJECT 19


IC 1739 138.5 69.1 149.0 10.6 2C 1745 121.8 77.9 128.2 10.7 3C 1674 144.6 86.5 151.1 10.0 4C 1755 188.1 79.0 184.7 11.7 5C 1755 179.1 83.5 180.3 11.3 6C 1472 174.9 68.1 173.8 10.8

7-8C 3850 379.4 162.2 360.1 27.4 9C 1783 173.5 75.3 175.3 12.0 LOC 1728 91.9 85.5 115.1 9.7

11-12C 3491 345.4 173.7 363.3 22.3 L3C 1751 168.6 81.7 161.4 9.6 14c 1770 183.6 79.7 192.6 10.5

IB 1761 158.6 60.4 159.9 12.5 2B 1741 161.8 69.2 166.9 13.9 3B 1764 181.5 82.4 187.8 14.5 4B 1701 124.3 75.0 140.5 14.4 5B 1683 167.5 68.1 174.0 15.7 6B 1741 154.3 77.0 162.6 16.2-

7-8B 3508 346.3 166.5 35B.9 34.1 9-10B 3515 314.4 161.8 336.8 34.6

1-1-12B 3567 309.7 160.2 319.5 33.9 13B 1784 170.6 87.1 174.6 17.9 14B 1764 148.1 81.6 169.3 18.1

15-163 3456 292.1 174.1 304.6 36.2 17-18B 3455 297.2 160.0 314.5 39.4 19-20B 3541 310.3 172.9 325.4 38,3. 21-22B 3605 286.4 163.9 304.6 39.4 2324B 3555 291.1 155.1 321.4 36.8 25-26B 3576 384.6 149.5 375.9 37.1

27B 1703 175.3 87,0 172.1 19.3 28B 1704 134.4 81.9 144.1 17.6

IR 1710 99.8 81.0 110.0 15.5 2R 1693 96.9 65.4 106.2 13.0 3R 1661 144.9 72.5 148.6 12.1 4R 1682 206.8 71.3 207.4 12.3 5R 1656 175.9 73.5 182.4 10.4 6R .1671 167.9 75.4 182.6 9.3 7R. 1740 117.3 71.8 131.1 7.8 BR 1903 121.1 82.2 123.1 9.6

9-10R 11-12R

3538 3473

327.5 319.2

144.7 132.5

338,8 353.4

16.9 13.4

13R 1727 188.1 71.0 187.6 6.8 L4R 1715 148.7 80.3 154.7 6.3

TABLE 23. N

URINE CHEMISTRY STJIMhIARY Excretion/24-48 Hours

SUBJECT 21

Day of Study Creatinine (mgm)

IC - 1645

20 1385 30 1019 40 -969 50 1578 60 1578

7-8C 2461 90 1674

[0c 1436 11-120 3295

130 1487

1B 1507 2B 1633 3B 1496 6B 1500

7-8B 2740 9-10B 3265 -1-12B 2963

13B 1634 [4B 1604 15B 1560 16B 1557

17-L8B 3327 19-B 3163 21-12B 3238 23- 4B 3471 25-26B 3108

?7B 1625 ?SB 1571

IR 1493 2R 1415 3R 1302 4R 1611 5R 1541 6R 1360 7R 1358 8R 1646

29-IOR 2939 11-12R 2824

13R 1394 4R 1562

Sodium (meq)

170.6 130.9 62.4-96.0 104.7 168.7 272.9 136.7 144.1 338.1 201.4

174.6 198.0 97.6 146.9 275.7 319.0 263.7 153.8 158.6 218.1 92.4

328.5 249.0 292.5 335.5 187.5 180.8 149.3

81.9 102.8 137.7 176.4 200.5 78.3

125.7 133!6

.238.7 219.0 132.3 170.5

Potassium (meq)

80.7 73.7 51.7 51.0 82.1 74.7

118.0 84.8 77.0

165.6 76.0

88.6 89.6 83.2 78.0

136.9 161.7 147.8

- 78.3 85.9 88.4 76.7

181.7 161.4 177.3 179.0 138.3 77.0 75.0

68.5 65.9 57.5 55.2 76.7 56.6 72.8 73.7,

137.3 95.0 52.5 70.5

Chloride (meq)

181.2 142.0 75.3

102.5 119.4 167.2 278.4 144.1 139.6 343.2 189.5

178.6 194.0 113.4 148.5 279.7 320.7 Z76.1 153.5 162.4 201.2 106.6 327.8 277.2 306.6 325.8 204.8 176.6 160.1

92.7 100.6 140.3 171.6 197.9 76.3 137.7 150.2 264.2 220.7 139.8 169.7

Calcium (meq)

8.0 8.4 4.4 5.7 6.1 8.0

13.7 6,5 7.9 17.3 7.6

8.4 7.8 -5.4 7.2

17.9. 17.7 21.510.6 11.4 12.5 9.0

22.5 20.5 21.4 26.4 18.1 12.0 11.6

8.1 7.7 8.7 8.1 7.8 .2'7;26.5

12.3-2 11.9 6.6 6;2

TABLE 23

URINE CHENISTRY SUNMkARY Excretion/24-48 Hours

SUBJECT 22

Day of Study Creatinine Sodidm Potassium Chloride Calcium


10 1393 126.9 28.8 108.2 17.6 2C 1843 100.4 40.2 104.4 15.8 30 1971 117.4 59.5 113.6 16.9 40 1940 142.7 50.7 127.3 17.2 5C 912 74.9 22.1 61.3 10.8 60 1420 110.1 38.3 105.0 15.6

: 7-80 3038 341.3 -89.5 325.6 30.2 90 1748 170.9 43.5 148.9 17.0

lO 1438 97.4 43.9 81.2 10,6 11-I20 3771 279.7 113.1 283.8 35.9

130 1484 157.6 50.0 161.2 14.9 140 1558 94.7 32.5 79.6 16.1

1B 2041 202.1 51.1 179.0 23.7 2B 1787 182.1 55.8 1-79.3 23.7 -3B 1830 139M3 52.1 139.4 22.9 4B 1901 145.9 72.9 139.1 22.1 5B 1890 161.5 62.4 151.5 21.5 6B 1827 156,6 64.3 149.7 20.6-

7-8B 3565 319.1 128.3 303.1 44.5 9-10B 3052 257.1 95.0 216.4 47.0

11-12B 4006 307.3 132.9 286.0 46.3 13B 1754 124.2 48.4 110.1 22,3 14B 1723 178.6 .51.0 166.6 24.7 15B 1940 230.2 70.8 200.0 23.1 16B 1951 142.2 63.7 140.0 22.0

17-18B 399& 302.9 140.4 293.5 43.4 19-20B 3948 244.7 112.5 236.4 46.9 21-22B 3919 314.9 122.3 299.4 47.523-24B 4142 290.8 108.9 283.5 49.5 25-26B 4068.9. 388.6 127.3 381.4 47.3

27B 1970 191.5 66.5 171.8 22.4 28B 1878 147.5 57.5 144.8 21.1

IR 1442 53.1 34.8 51.5 13.22R - 1526 51.8 39.3 64.8 15.0 3R 1880 102.0 51.0 107.4. 19.84R 1546 139.9 49.7 125.1 13.9 5R 1708 163.0 50.5 152.1 17.5: 6R 1134 84.2 27.3 89.9 13.1: 7? 1583 170.7 48.1 162.1" 17.28R 1436 83.4 34.7 71.8 12.2

9-10R 2554 190.1 58.5 168.6 23.9 11-12R 1975 158.4 39.9 130.8 16.7

13R 1185 844 26.0 64.5 8.9 14R 1259 102.6 39.3 101.0 1, a

84

TABLE 23

URINE CHEMISTRY SUMMARY Excretion/24-48 Hours

SUBJECT 23

Day of Study Creatinine Sodium Potassium Chloride Calcium (mgm) (meq) (meq) (meq)' (meq)

1C. 2289 '178.9 73.2 155.1 13.6 2C -2017 104.3 68.6. 110.1 12.6 3C -2078 136.0 69.0 136.2 13.340 1980 160.6 67.8 155.8 -12.9 5C -2085 182.2 75.6 167.7. 13.6

- 6C 2018 101.4 67.6 115.3 13.8 7-80 4076 250.5 137.3 249.0 28.2 . -9C- 1713 155.8 60.3 139.9 12.5 10C 2461 161.9 75.2 157.4 16.5

-1-12C 4195 262.8 144.0 256.3 28.6 :13C 2015 166.0 71.0 146.3 14.8

140 1736 108.9 40.6 91.9 13.3

IB 1930 273.1 49.0 2 0.9 17.8 2B 2089 162.1 69.9 165.1 15.9. 33 2046 181.5 -83.3 175.9 16.0 43 2047 134.5 82.4 134.0 14.9 5B 2075 116.0 82.0 121.9 16.0 .6B -1978 121.6 77.2 124.3 16.6

7-8B 3701 296.3 142.5 289.4 32.1 9-10B 3987 323.6 128.6 297.4 35.2 11-12B 3842 270.5 155.3 289.8 38.3

13B 1999 168.7 71.8 157.8 19.2 14B' 1936 139.7 60.6 139.0 19.7

15-16B 3683 283.7 139.5 283.4 37.5 17-18B 4524 283.5 132.3- 260.2 -39.5 19-20B -3850 281.7 133.7 -262.0 37.4 21-22B 4143 337.4 133.7 316.2 42.0 -23-24B 4004 251.9 138.7 255.8 36.5 25-26B 4i79 272.2 130.0 259.5 40.3

27B 2061 147.4 68.9 135.9 19.1 28B 1965 132.7 61,5 124.5 18.4

IR 2115 121.8 66.2 121.8 21.0 2R 2201 135.2 51.4 120.9 -20.4 3R. 2083 59.5 42.0 62.4 19.2 4R 1723 47.1 47.1 64.7 15.1 5R- 2069 188.5 61.6 176.7 18.7 6R 1879 159.3 48.7 132.6' 15.3

-. 7R .1965 -.187.0 .- 56.6 173.9, 17.4 --8R 2045 125.8 50.8 117.4,. 16.3

'9-10R 4089 400.7 ..... 143.8 379.1' 32.411-12R- 3845 140.2 116.8 138.3. 24.0 " 13R "14R

1949 1990

125.5 136.1

61,4 68.9

123.2 136.7

13.4 9.7

TABLE 23

URINE CHEMISTRY SUMIARY Excretion/24-48Hours

SUBJECT 24

Day of Study Creatinine (mgm)

Sodium (meq)

Potassiumc (meq)

Chloride (meq)

Calcium (meq)

IC 2-3C 4-5C 6-70 8-9C

10-11C 12-13C

14C

2206 4362 4082 4351 4225 4318 4347 2126

158.1 387.2. 267.2 359.5 255.9 338.2 333.1 115.7

77.7 169.0 152.0 162.2 14-L. 152.5 151.4 *60.8

170.9 364.7 271.7 362.6 256.9 336.7 331.5 105.7

14.1 28.6 24.5 28.7 26.4 31.2 31.3 15.4

1B 2B

3-4B 5-6B • 7B 8-9B

10-11B 12-13B

14B 15-16B 17-18B 19-20B

21B 22-23B 24-25B 26-27B

28B

2362 - 2447 4737 4868 2262 4748 4860 4933 2213 4905 4739 4870 2454 4753 4925 4528 2211

252.6 169.4 350.7 263.2 153.6 422.9 298.3 326.1 191.4 390.8 328.7 357.4 172.1 314.1 354.2 313.8 166.9

65.5 75.P 174.6 176.2 74.8 172.6 187.8 171.5 -65.4 180.1 163.1 173.7 86.1 184.6 168.9 156.1 76.0

213.8 183.3 355.5 276.9 144.4 391.1 313.8 320.8 171.9 385.6 334.5 354.8 164.8 315.8 355.5 310.6 144.5

20.0 18.6 37.9 38.3 19.9 38.2 37.1 39.0 17.0 38.1 34.3 36.7 18.6 35.6 37.8 35.3 16.7

IR 2R

3-4R 5-6R

7R 8-9R

10-11R 12-13R

14R

2171 2329 4350 4364 1916 4084 4353 4294 2059

64.1 117.1 262.1 331.5 147.9 259.8 227.7 275.2 169.0

63.4 57.2 117.5 133.0 54.3

122.7 ±24.2 127.3 53.0

89.9 126.0 263.9 313.1 146.2 274.9 240.8 278.0 171.7

15.6 16.7 29.6 30.1 14.2 27.8 29.0 30.7 17.7

86

TABLE 24

-URINE NITROGEN SUhRY (Grams/Collection Period)

Day of Subject Day of Subject Day of Subject Day of Subject Study I Study 2 Study 3 Study 4

-1C 1066 1C 11.81 1C 13.74 1C 13.02 20 11.45 20 12.79 20 11.14 20 12.12 30 11.60 30 12.63 30. 11.16 30 13.28 40 12.37 40 12.76 4C 9.96 40 12.59 50 10.03 50 12.22 50 10.97 50 10.39 60 9.93 60 11.38 60 10.28 60 10.90

7-80 18.48 7-8C 19.58 70 10.74 7-8C 21.48 9,I00 -19.12 9-10C 20.28 8-9C 20.90 9-100 23.52

11C 9.80 11C 11.17 10-11C 23.22 1IC 11.34 12C ".10.22 120 13.26 12C -10.35 120 11.58

13140 21,48 13-140 22.32 -130 11.00 13-140 20.82 14-150 21.22

IB 11,00 1B 11.95 IB 10,g24 IB 8-81 2B 11:62 2B 12.68 2B 10.14 2B 11.21 :3B 13.60 3B 11.94 3B 8.62 3B 11.81 4 -1-1-.4 4B 12.81 -4B 9.71 4B 12.12 75B o4I 5B 9.81 -5B 11.45 5B 9.31 6B f3.61 6B 16.66 6B 11.80 6B 13.23

S-8B 23,10 7-8B 25.94 7-8B 24.50 9-10B 20.74 910B 26.06 9-10B 27.36 9-10B 22.24 11-12B 23.72

13B 13.44 13B .13.66 13B 11.75 13B 12.21 - -14B 13-00 14B 13.06 14B 11.19 14B 11.68 [5-16B 23,74 15-16B 29.30 15-16B 24.36 15-16B 26.12 [7i18B 2482 17-18B 26.82 17-18B 22.54 17-18B L..04 [9=20B 24,56 19-20B 26.42 19-20B 22.38 19-20B 25.52 :21B 1.l88 21B 12.17 21B 8.79 21B 11.37

Z2-23B 23.06 22-23B 25.08 22B 11.50 22B 11.97 '4-25B 25.26 24-25B 24.52 23-24B 22.20 23-24& 2-7.60 Z6-27B 23.64 26-27B 23.62 25-26B 23.30 25-26B 25.08 -28B *11.47 28B 12.00 .27B 11.41 27B 12.72

28B 10.57 28B 10.89

IR 11.54 IR 10.27 -IR 10.85 IR 12.60 2R 18.50 2R 12.54 2R 8.92 2R 13.05 T3R 10.50 3R 13.87 3R 10.84 3R 12:32 4R 11.45 4R 11.16 4R 10.93 4R 11:08 5R 9--68 5R 9.51 .5R 8.91 5R 1E.23 ±6R 10037 6R 9.91 6R 9.85 '6R 9..17 -7R 10.89 7R 9.94 7-8R 14.66 7R - 8.46 8:9R I--H.36 8-9R 19:90 9-10 17.98 8R 9.96

0:.I1R 1-774 10-11R 18.20 -13R. 9.15 9-T0R- 14.92 -2r.I3R 15.14 12-13R 1f66 . 14R 9.36 11-12R 19.08 Z14R -.42 14R 7.81 13R '7.79

14R 6.71

-87

TABLE 24

URINE NITROGEN SUlHARY (Gram/Collection Period)

Day of Subject Day of Subject Day of Subject Day of Subject Study 5 Study 6 Study 7 Study 8

iC . 9.84 IC 12.19 1C 13.03 IC 30 10.53 30 11.49 20 13109 20 13.61 -40 - -916 40 9.21 30 12.96 30 11.03 15C 9.92 50 13.50 40 12.78 40 13.77 60 11.68 60 9.01 50 13.20 50 13.80

7-80 20.36 -7-80 19.42 60 -11.83 60 13.79 '9C 9,72 90 12,52 90 11.92 90 11.95

-,"IOC 8.72 10C 11.23 10C 13.65 10C 12.49 11-12C 21.92 11-120 23.82 11-120 27.58 11-120 25.68 13-140 23T50 13-140 24.62 -130 12.30 ,130 13.86

140 13.41 140 10.58

B 1I.75- B 14.35 IB 14.27 IB 12;99 2B 10.77 2B 14.55 2B 12.86 2B 12.,98 3B 10.69 3B 12.41 3B 13.72 3B 132I0 4- 1f7-2 4B 11.23 4B 14,42 4B -15,51 5B 11.-66 5B 13.62 5B 9.61 5B 8;03 63 1f.92 6B 11.89 6B 14.63 6B 14.47

7-8B 24.20 7-8B 27,62 7-8B 26.72 7-SB 29.02 9-1-0B 22'.92 9-10B 26.46 9-10B 29.36 9-10B 28.24

11-12B 21.64 11-12B 28.24 11-12B 27.76 13B 14.59 13B 11-.39 13B 11.51 13B 13.78 14B 14.13 14B 12-;53

1I-5B12. -14B 15B

15.08 12,56

14B 15416B

14.15 18.18

15-16B 17-18B

24.38 -28.60

17-18B- 22.:68 16B 9.82 17-18B 28.98 19-20B -27.82 19-20B 25,-l 19-20B 29.60 19-20B 29.48 21-22B .28.74 21-22-B 22.44- 21-22B 24.16 25-26B 28.88 25-26B -,3214 23-24B 24.76 23-24B 24.66 27B 14.94 25-26B 23.68 25-26B 25.68 28B 11.75

-27B 12.30 27B 13.39 28B 11.32 28B 14.09

IR 10.57 IR 14.84 IR 13.50 IR 15.00 2R 11.04 2R 14.21 2R 11.61 2R 13.03 3R I0.93- 3R 12.72 .3R 14.35 3R- 13.31 4R 11.09 4R 17.96 4R 13.72 4R 14.35 5 i11,11 6R 15.12 5R 13.13 5R 15.71 6R 5-.65 7R 9.75 6R 13.45 -6R- 14i07 7k 11.56 8R 13.45 7R 10.77 7R 12.13 8R -o9.-63 9-iR 28.82 8R 13.63- 8R 12.-94

9-fOrv 21:l1g. 11-12R '1570 9-10R 26.82 9IOR ;325z14 11-12R !'.I34 13R 10.74 11-12R 24.34 11-12R .25.60

4 3R 92-83 ° , 14R 12.52 -13R 11.64 13R -15;1 3

'14R 11.37 14R 11.64

as4

TABLE 24.

URINE NITROGEN SUNMRY (Gram/Collection Period)

Day of- Subject Day of Subject -Day of Subject Day of Subject Study 9 Study 10 Study 11 Study 12

1C 16.66 10 14.16 1C 16.57 10 14.29 2C 17.70 30 14.53 20 16.94 20 14.88 30 16.29 40 13.74 30 16.57 30 14.44 40 15.67 5C 14.00 40 16.86 40 13.01 5C 15.93 60 .14.73 50 16.65 50 13.42 60 14.97 7-8C 27.44 60 17.05 60 12.98

7-80 -30.92 90 13.55 7-80 33.28 7-80 23.86 -90 13.71 10C 13.06 90 16.50 90 11.88 10C 16.94 11-120 26.00 100 14.59 10C 12.96 -

11-120 29.5-6-- 130 13.72 13C 15.94 130. 13.27 130 14.42 140 11.83 140 15.34 14C 12.96 140 13.05

IB 14.64 IB 14.18 1B 17.81 IB 12.24 - 2B 14.83 2B 13.37 2B 17.34 2B 13.39 3B 15.16 3B 12.90 3B 17.08 3B 13.79 4B 14.-4-5 4B 12.97 4B 16.39 4B 12.95

5B 14.80-0 5B 13.53 5B 16.53 5B 1-3.34 6B 14.75 6B 12.19 6B 16.15 6B 12.64

7-8B 31.14 7-8B 29.24 7-8B 32.94 7-8B 26.14 9-10B 30.50 9-10B 28.78 9-10B 33.04 9-10B 26.28 11-12B 29.94 11-12B 28.80 11-12B 33.62 11-12B Z6.40

13B 15.53 -13B 14.81 13B 17.17 13B 13.37 14B 14.98 14B 12,92 14B 16.80 14B 13.79

15-16B 30.52 15-16B 27.68 15-16B 34.50 17-18B 25.54 17-18B 30.76 17-18B 29.06 17-18B 33.24 19-20B 27.16 19:20B 30.72 19-20B 29.14 19-20B 32.16 21-22B 27.26 21-22B 32.30 21-22B 29.42 21-22B 34.30 23-24B -27.52 23-24B 32.04 23-24B 28.78 23-24B 35.62 25-26B 27.44 25-26B 30.98 25-26B 28.88 25-26B 33.78 27B 13.69

27B 16.30 27B 14.32 27B 16.98 28B 12.88 28B 16.35 28B 14.72 28B 17.14

IR 16.43 IR 16.12 IR 17.42 IR 13.28

2R 16.21 2R 13.12 2R 20.60 2R 12.75 3R 17.18 3R 14.39 3R 19.06 3R 14.54 4R- 17.06 4R 15.00 4R 17.48 4R 12.35 5R 16.28- 5R 13.59 -5R 16.83 -5R 11.77 6R 13:43- 6R 13,06 6R 17.34 6R 11.27 7R 14.n-'-' 7R. 14.08 7R 15.15 YR 12.12 8R 15.43-- 8R 13.62 8R 16.18 - 8R 11.68

9-1 P- 29.48 9-10R 27.08 9-10R 34.84 9-10R 22.62 11-12R -30.24 11-12R 26.50 11-12R 31.24 11-12R -24.14

13R- 14.27- 13R 11.64 13R 15.86 13R :9.78 14R- 13.80- 14R 12.21 14R 13.54 _.14R 11.84

TABLE 24

URINE NITROGEN SUI'n4ARY (Gram/Collection Period)

Day of Subject Day of Subject Day of Subject Day of Subject Study 13, Study 14 Study 15 Study 16

IC 13.35 10 9°57 1C 11.28 1C 14.24 20 12.83 20 12.36 20 11.19 20 16.05 30 '12.73 30 11.81 3C' . 9.11 30 14.45 -40 13.60 40 12,76 40 11.26 4C 15.00 50- 12.60 5G 12.28 50 9.75 50 415.89 60- 13;70 60 11.86 60 11.30 60 -14.05

-W8C 26,34 7-8C 23.72 7-80- 18.80 7-80 27.02 90 12.54 90 12.31 9C 9.76 -9c .16.92

-iOG -.125.3- 00 -11.35 10C 13.45 10C 15.52 11-12C0 25:42 11-120 22.76 11-120 20.32 11-120 25.70

-1-3 12-44 13C 11.12 13C 9.78 130 15.46 i4c I2458 L40 10.77 L4C 10.21 140 12.77

:B13.02 IB 13.56 1B 14.33 1B 17.16 -2B. 12.33 2B. 11.83 2B 13.72 2B 16.29 3B: IT-43-1 3B 13.18 3B 13.04 -3B 15-.07 4B- 11136 4B. 12,09 4B 13.69 .4B, 20.26 5& 121-7 .53 11.57 5B 14.40 -5B 16.79 6B- 10.86 - 6B 11.32 6B 15.51 .6B. 17.74

7-8B -24-92 7-8B 24.72 7-8B 2846 7-8B 35.44 9-10B 25.12 9-10B 24.82 9-10B 29.42 9-10B 35,58 l12hB 25.12-- 11-12B 25.54 11-12B 30.20 11-12B -37.74

137B 13-53 13B 11.13 13B 15.36 13B 15.55 I-1< -12.38'W - 14B 13.31 -14B 14.39 -14B- 20.30

15-16B- 24*52-* 15-16B 24.78 15-16B 26.08 15-16B ,-3a.96 17-18M' C269 17-18B 27;72 17-18B 23.60 17-18B -37.80 19-20B 26.14 19-20B 25.76 19-20B 25.62 19-20B 35.04

-21-22B 26.80 21-22B 27.50 21-22B 26.10 21-22B 35.84 23-24B 26.82 23-24B 26.66 23-24B 29.72 23-24B .34.70 25-26B-- -26.94 25-26B 26.10 25-26B 27.22 25=26B .39.22

27B - 12.33 27B 13.33 27B 14.04 27B 16.39 28B 13.86 28B 12.25 28B 14.68 28B 16.21

IR 10.29 IR 13.53 IR 11.87 iR, 13.77 2R -

3R:-- 9.35 10-30-

2R 3R

12.01 12.39

ZR ..3R

15.57 11.15

2R .43R-

14;88 13.-17

=5--=4R-14-91

-7-5-4R 5R

11.19 10.49

4R 5R

9.77 10.24

_4R :5RK

17.45 13130

6R' l--36 6R 11.2? 6R 12.73 .6R 12.82 7 i6.-6 7R 9.79 7R 10.58 .7R 17;34 8R 1i.-5 8R 9.40 - SR 9 42 t8R 16.66

9-10R,- 20,86 - 9-10R 18.80 9-10R 21.12 9-16R 6.98 l-'.-12 -2-1.18 11-12R 18.80 11-12R 31.40

13R I0.b0 13R 9.59 13R 16.32 14R 8.04 14R -7.10- 14R 16.02

90

TABLE 24

URINE NITROGEN SUMMARY

(Gram/Collection Period)

Day of Subject Day of Subject Day of Subject---Study - 17 Study 18 Study 19

IC 13.60 IC 16.31 IC 16.10 2C 12.42 2C 14.91 2C 16.07 30 12.90 30 15.54 3C 17.93 4C 14.42 4C 16.40 4C 17.54 5C 14.46 5C 13.87 5C 16.48 60 13.23 6C 12.89 6C 14.83-.

.-7-8C 29.72 7-80 27.96 7-8C 36.689C 14.77 9C 16.77 9C 16.72 LOG 14.88 10C 15.36 10c 16.36

11-12C 27.54 11-120 30.72 11-12C 33.46 3C 15,90 14C. 16.26 13C 16.32

L4 15.26 14C 17.44

_IB 14.29 IB f16.95 IB 16.26 .2B 15.14 2B 15.71 2B 15.76 --B 14.73 3B 17.47 33 15.88 4B_ 15.50 43 17.01 43 16.21 .35 15.38 5B 16.73 5B 16.31

__kB 15.21 63 16.59 63 16.52 -7-8B 30.98 7-8B 34.98 7-8B 32.68 9-103 31.72 9-103 .35.74 9-103 33O08 1312B 31.10 11-123 35.22 11-12B 33.36

L3S 16.03 13B 17.13 133 16.50 143 16.51 143 17.20 14B 13.78

15-163- 27.20 15-163 34.80 I1-16B 33.98 17-18B 31.88 17-183 36.92 17-18B 32.26 19 203 32.74 19-20B 36.06 19-20B 31.82 21Z22B 28.44 21-223 40.86 21-22B 30.26 23-243 31.58 23-24B 36.52 23-24B 31.2025-Z263 30.10 25-263 36.44 25-26B 31.78

27B 15.74 273 16.32 273 15.41 28B 14.14. 28B 17.43 28B 15.85

-IR 15.44 IR 16.95 IR 17.27 .2R 16.93 2R 17.56 2R 17.45 ,J)- 15o87 3R 18.33 3R 15.73 -5R 15.86- 4R 12.13 4R 16.44 _6R- 14.48 5R 15.99 5R 14.74 _7R. 14.76 6R 15.82 6R 14.81 .8R_ 15.30 7R 15.09 7R 14.58

9XtC0( 28.20 8R 11.91 8R 16.56 Utl,42R 27.46 9-10R 29.00 9-lOR 31.04

13R 14.52 11-12R 28.24 11-12R 27,64 14R 13.63 13R 13.34 13R 14.40

14R 15.75 14R 15.27

Day of Subject Study 21

iC 2C. 13.17 3C 8.39

-4C 8058 5C 13.14 6C 14.46

7-8C 21.26 -- 9C 13.51 10C 12.99

11:-12C 27.66 13C 13.03

--- 14.09

--1B 13.91 2B 15.11 -3B 13.80 -6B 14.91 iB 27.92

vr 0B 31.14 1.Zl2B 31.30

-13B 14.89 14B 15.73 5-5B 16.02 --. 15.586B

1 -- 31.1218B 19A20B 30.52 21-22B 31.70 2a-24B 33,42 25-26B 27.62 --27B 14.57 C28B 13.88

-IR 13,04 t2R 13.26

-- 13.193R -R 12.88 5R 12.23 -6R 10o59 - 13.37 8R 12.76

-92>OR 22.96 11-12R 20.60

-13R 10.30

14R 10,67

TABLE 24

URINE NITROGEN SUMMARY :Gram/Collection Period)

fa-y .of Subject Study 22

1C 13.35 2C 14.06 3C 15.64 4C 14.30 5C 9.50 6C 12.12

7-8C 21.44 9C 7.81 10C 11.74

11-12C 28.80 13C 11.52 14c 9.73

1B 15.15 2B 15.69 3B 14.40 4B 15.56 5B 15.72

6B 15.48 7-8B 32.02

9-10B 32.50 11-12B 32.90

13B 16.55 14B 15.71 15B 16,00 16B 15.83

17-18B 33.04 19-20B 31,34 21-22B 30.96 23-24-B 32,10 25-26B 30.78

27B 15,79 28B 14,66

IR 12.04 2R 11,68

3R 14.24 4R 11.55 5R 12.84 6R 8,27 7R 11.99 8R 10.70

9-10R 19.78 11-12R 14.86

13R 9°34

-14R 9.39

Da of Subject Study 23

1C 19.24 20 .18.31 3C 18.04 4C 16.75 5C 18003 6C 17.44'

7-8C 33.16 9C 14.31 10C 19.31

. 11-12C 32,78 13C 16.96 14C 13.72

1B 18,02 2B 17.47 '3B 18.51 4B 18.847 5B 19.59 6B 18.27

7-8B 32.40 9-10B 37.12 11-12B 36.42

13B 18.04 14B 17.51

15-16B 31,42' 17-18B 36.60 19-20B 35.24 21-22B 35.78. 23-24B 32,98 25-26B 35.78

27B 16.87

28B 16.17

IR 16.24 2R 18.98

3R 16.84 4R 16,45 5R 17.02 6R 13.58 7R 15.11 8R 14.68

9-IR 28.46 11-12R 27.20

13R 13.28

14R 14.13

TABLE 25

AVERAG DAILY SODIUM EXCRETION BY WEEK OF STUDY (meq/24 hrs)

Subject Ambulant Be'drest gecovery

Week 1 2 Mean 1 2 3 .1 2

.71.40 89.24 80.32 102.38 103.24 96.28 99.'28 85.19 67.96 2 72.40 93.82 83.11 106.60 101.83 93.09 98.63 87.83 76.60 3 83.96 92.38 88.17 96.25 78.35 87.81 78.79 64.72 92.29 4 86.44 81.82 84.13 102.15 92.37 92.84 96.22 71.00 99.28 5 132.78 148.18' 140.48 154.44 160.12 151.98 159.94 141.38 152.84 6 97.76 •124.16 110.96 141.49 142.64 133.70 140.78 130.30 138.10 7 133.82 144.68 139.25 153.83 156.05 136.58 140.68 141.29 142.93 8 136.98 131.37 134.18 164.46 150.66 162.92 159.18 121.05 139.60 9 149.36 158.74 154.05 162.50 157.99 169.56 166.96 147.14 167.95

10 154.86 142.71 148.79 158.37 150.40 157.06 157.82 145.83 153.63 11 147.56 143.47 145.52 165.99 161.33 168.55 151.92 149.60 146.63 12 142.25 142.51 142.38 158.42 157.49 154.18 149.09 132.59 124.70 13 148.89 160.50 154.70 165.71 164.47 148.61 162.35 122.93 130.33 14 157.75 160.34 159.05 192.53 172.91 167.63 168.09 148.14 149.27 16 129.84 113.26 121.55 171.77 150.66 147.90 164.11 131.39 154.89 17 160.04 156.07 158.06 184.68 172.15 169.04 171.09 146.78 166.20 18 130.69 153.72 142.21 171.24 159.26 168.21 146.97 118.69 125.07 19 162.39 164.69 163.53 160.16 159.42 143.97 161.23 - 144.21 157.80 21 124.25 159.46 141.86 150.99 147.56 147,75 142.76 129.04 127%73 22 120.44 138.71 129.58 163.86 146.68 153.92 167.98 109.24 68,i3

Mean 127.19 134.99 151.39 144.28 142.83 144.19 123.42 130.10

SE (95%) 13.73 12.54 13.00 12.79 13.0P 13.08 12.41' 14.02

TABLE 26

AVERAGE DAILY POTASSIUM EXCRETION BY WEEK OF STUDY

(meq/24 hrs)

Subject

Week

Ambulant

2 1

Bedrest

2 3 4

Recovery

1 2

1 2

3 4 5 6 7 8 9

10 11 12 13 14 16 17 18 19 21 22

54.91 51.32

55.01 62.24 53.74 47.29 53.21 50.59 57.52 68.21 79.65 60.02 61.72 63.83 66.85 70.93 70.64 77.89 67.56 40.62

57.71 58.93

58.20 53.09 57.10 60.04 64.48 53.31 56.56 67.09 72.85 54.77 62.24 60.77 61,52 72.73 71.03 82.43 77.07 46.82

56.31 55.13

56.61 57.67 55.42 53.67 58.85 51.95 57.04 67.65 76.25. 57.40 61.98 62,30 64.19 71.83 70.84 80.16 72.32 43.72

67.65 64.76 58.57 62.70 63.35 66.57-64.23 64.89 58.81 68.13 79.18 62.74 63.59 66.36 79.77 78.99" 77.31 73.62 81.57 60.39

67.03 69.43 54.99 60.31 60.82 69.89 68.00 66.49 61.82 75.27 78.32 64.74 64.68 67,94 80.06 85.09 85.59 81.99 77.45 55.92

64.92 64.29 56.65 64.69 67.55 67.07 54.53 62.24 63.99 72.31 79.34 57.47 .67.56 70.96 84.94 79.24 86.09 84.14 85.26 64.08

71.75 63.71 54.55 64.85 69.04 74.57 69.26. 59.57 62.62 72.40 69.39 57.54 71.65 69.27 84.58 81.23 83.70 79.35 79.71 60.19

58.34 55.96 50.67 54.60 55.08 58.68 60.50 51.76 54.73 66.75 73.64 50.67 54.09 60.37 62.93 75.83 71.61 72.99 64.74 42.96

56.00 55.03 48.95 50.68 63.82 62.88 61.04 50.39 58.90 73.06 64.95 44.10 50.50 65.07 68.69 76.84 70.37 73.39 61.29 28.34

Mean 60.69 62.44 68.16 69.79 69.86 69.95 59.85 59.21.

SE

(0 (95%) I 77 4.19 3.5.0 4.33-, 4.69 4.10 4.14 5.44

TABLE 27

Subject

1 2 3 4 5 6 7 . 9

10 11 12 13 '

14 16 17 18 19 21 22

Mean

SE (95%)

Week 1

85.91 91.45 94.88 95.93

146.32 116.94 145.05 146.76 158.87 168.06 151.92 148.25 151.45 156.01 129.30 167.97 137.06 163.91 132.46 111.84

135.02

12,45

AVERAGE DAILY CHLORIDE EXCRETION BY WEEK OF STUDY (meq/24 hrs)

Ambulant Bedrest

2 Mean 1 2 3 4

94.06 89.99 103.99 100.87 94.61 85.50

97.37 94.41 105.27 89.77 96.50 95.10

88.15 91.52 95.71 93.81 95.95 91.34

91.29 93.61 103.80 99.63 96.37 102.13

157.17 151.75 166.43 168.50 161.79 171.54

130.98 123.96 156.87 155.08 146.58 150.00

121.70 133.38 155.60 154.11 130.17 138.92

136.19 141.48 156.55 153.00 158.69 154.75

166.64 162.76 162.34 160.14 173.52 172.38

153.59 160.83 169.08 '159.73 161.28, 164.29

151.53 151.73 165.22 157.71 162.44 142.83 145.61 146.93 162.10 161.55 156.58 154.03

161.72 156.59 164.28 165.52 150.14 163.83

152.76 154.39. 181.04 172.57 156.22 159.61

112.38 120.84 167.61 147.57 146.80 160.22

161.78 164o88 186.86 171.38 169.46 172.30

157.56 147.31 181.28 165.36 173.40 152.38

169.71 166o81 167.36 168.56 156.71 166.58

159.30 145.88 154.90 150.39 152.33 145.82

131.10 121.47 155.71 132.98 145.68 161.62

137.03 153.10 146.41 144.26 145.26

12.75 12.pi 12.85 .12.52 13.23

R6covery

1 2

86.74 66.95 91.69 83.76 75.49 97.79 77.33 102.57 151.15 164.07 139.47 129.72 137.88 136.70' 127.52 142.35 156.06 173.74 163.13 166.27 143.75 136.73 139.25 129.29 126.36 129.84 141.88 141.62 122t45 149.68 145.84 168.35 124.72 132.63 152.66 165.40 131.07 134.97 99.03 76.71

126.67 131.46

12.47 14.65

CA

TABLE 28

AVERAGE DAILY CALCIUM EXCRETION BY WEEK OF STUDY (meq/24 hrs)

Subject Ambulant Bedrest Recovery

Week 1 2 Mean 1 2 3 4 1 2

1 1"5.43 12.57 14.00 16.99 19.23 20.83 23.55 13.49 10.13 2 14.97 13.75 14.36 15.83 16.55 18.56 16.45 12.07 ..9,80 3 9.71 9.97 9.84 11.48 12.98 14.50 13.48 9.80 7.95 4 5.56 5.89 5.73 8.21 9.13 9.27 8.74 5.51 5.22 5 9.20 9.61 9.41 11.20 13.25 13.83 14.21 11.48 8.70 6 18.35 20.61 19.48 26.59 30.69 29.26 28.34 21.92 19.08 7 8.83 9.90 9.37 8.87 10.29 12.01 11.66 9.94 8.16 8 12.61 13.46 13.04 16.84 17.79 18.87 20,20 15.98 12.57 9 7.06 7.25 7.16 8.09 7.15 8.39 8.60 7.44 7.00

10 12.54 12.69 12.62 15.58 16.85 17.82 17.66. 13.53 11.77 11 13.95 13.54 13.75 18.16 19.19 18.54 17.36 14.76 13.12 12 12.51 12.15 12.33 14.85 15.68 16.74 16.43 13.46 12.54 13 8.74 10.63 9.69 12o32 15.01 12.71 14.58 11.08 7.52 14 11.21 12.62 11.92 15.21 17.20 15.69 20.42 13.39 9.80 16 13.15 13.99 13.57 20.17 20.25 24.22 25.81 16.38 12.30 17 11.30 11.03 11.17 13.04' 12.30 16.32 13.16 9.54 10.29 18 5.49 5.87 5.68 7.30 8.21 8.04 10.57 8°44 6.58 19 11.32 11.16 11.24 14.94 17.39 19.11 18.68 11.53 7.62 21 6.83 7.73 7.28 7.59 10.06 10.77 11.28 7.44 6.24 22 15.60 15.69 15'65 22.43 23.23 23.77 23,46 15.73 10.68

Mean 11.22 11.51 14.28 15.62 16.46 16.72 12.15 9.85

SE (95%) 1.65 1.63 2,43 2.62 2.60 2,62 1678 1,49

TABLE 29

AVERAGE DAILY NITROGEN EXCRETION BY WEEK OF STUDY (gm/24 Hrs)


Week 1 2 Mean 2 3 4 1 2

1 10.75. 9.85 10.30 11.89 12.81 12.14 11.92 11.84 8.52 2 11.91 10.97 11.44 12.69 13.41 13.53 12.17 11.03 9.08 3 11.14 10.84 10.99 10.60 11.49 11.15 11.28 9.66 8.76 4 11.86 11.14 11.50 11.08 11.39 12.72 12.61 11.13 8.35 5 10.22 10.58 10.40 11.37 11.51 11.89 11.90 10.28 10.33 6 10.85 11.70 11.28 13.12 13.59 12.81 12.84 14.10 11.60 7 12.82 13.14 12.98 13.27 14.06 12.77 13.89 12.93 12.54 8 13.20 12.43 12.82 13.08 14.29 13.60 15.50 13.94 12.92 9 16.10 14.73 15.42 14.84 15.22 15.45 15.97 15.83 14.75 10 14.15 13.13 13.64 13.39 14.28 14.37 14.49 14.19 13.01 11 16.75 15.80 16.28 16.82 16.73 16.72 17.24 17.70 15.95 12 13.44 12.60 13.02 13.06 13.27 13.27 13.59 12.58 11.44 13 13.14 12.65 12.90 11.93 12.66 13.00 13.34 11.12 10.18 14 11.79 11.45 11.62 12.27 12.45 13.14 13.16 11.52 9.10 15 10.47 10.42 10.44 14.13 14.80 12.62 14.10 11.70 10.18 16 14.74 14.27 14.50 17.29 18.13 18.10 17.78 14.68 15.34. 17 13.70 14.74 14.22 15.11 15.84 15.15 15.11 15.56 14.16 18 14.84 15.52 15.18 16.85 17.54 18.32 18.26, 15.95 14.03 19 16.76 16.95 16.86 16.18 16.15 16.17 15.62 15.86 14.99 21 11.78 12.97 12.38 14.34 15.29 15.58 15.05 12.65 11.04 22 12.81 11.47 12.14 15.43 16.24 15.96 15.54 11.80 9.15 23 17.77 16.24 17.00 18.13 17.90 17.31 174i0 16.32 13.96

Mean 13.23 12.89 13.95 14.50, 14.35 14.47 13.29 11.79

SE (95%) 0.97 0.91 0.92 0.92 0.89 0.99 1.10

Control Weeks

Bedrest Week

Day 1B

Day 2B

TABLE 30

PAIRED "t" TEST ANALYSIS Urine Electrolyte and Nitrogen Excretion

Control Week Bedrest Week

1 2 1 2 3 4

Sodium Potassium Calcium Chloride Nitrogen

<.001 <.001 <.001 <.001 <.005

<.001 <.001 <.001 <.001 <.001

<.001 <.001 <.001 <.005 <.001

<.001 <.001 <.001 <.01 <.001



<.001 <.9 <.001 <.001 <.005

<.001 <.01 <.2 <.01 <.9


<.01 <.I <.005 <.001 <.005

<.9 <.3 <.001 <.2 <.5

Recovery Week

1 2

<.02 <.9 <.1 <.2 <.025 <.001 <.005 <.3 <.4 <.001

<.001 <.005 <.001 <.001 <.001 <.001 <.001 <.01 <.001 <.001

TABLE 30

PAIRED "t" TEST ANALYSIS

Urine Electrolyte and Nitrogen Excretion

Control Week Bedrest Week Recovery Week

1 2 1 2 3 4 1 2

Day IR


<.001 <.001 <.001 *<.001 <.10

<.001 <.6 <.025 <.001 <.02

Day 2R


<.001 <.001 <.00i <.001 <.71

<.001 <.05 <.9 <.001 <.05

TABLE 31.

DIET ANALYSIS (meq/24 Hours)

Subject Day of Study Sodiunm Potassium Calcim(ti

8C 106.5 77.2 49.8 1 8B 117.2 85.0 55.4

22B 110.1 77.6 48.3 8R 110.6 78.6 49.5

80 106.3 74.1 48.6 2. 8B 106.4 73.3 48.8

22B 109.2 73.8 49.0 8R 110.5 74.1 49.5

113.6 77.5 52.0 3 IB 110.2 73.7 45.6

10B 110.6 76.2 52.1 IR 107.0 72.1 48.4

90 107.2 72.5 49.1 4 9B 110.0 77.1 49.4

23B 114.8 77.6 51.4 8R 109.4 76.2 49.6

9C 172.4 79.3 40.2 9B 176.7 82.5 39.1

5 23B 178.6 82.3 47.7 IR 56.9 35.5 48.4 9R 172.6 81.4 45.5

8C 164.6 86.0 45.7 6 8B 165.6 89.9 42.6

22B 161.5 88.7 44.1 8R 166.4 89.8 38.6

7C 170.6 81.0 48.1 7B 170.9 80.3 48.6

21B 165.6 79.0 48.7 7R 167.0 78.7 47.9

8C 178.2 93.7 53.3 9B22B 175.4173.7 94.393.1

52.953.1

8-9R 171.8 90.3 52.2

7C 174.6 74.6 44.0 9 7B 182.8 78.4 44.4

21B 182.8 77.5 43.4 7R 178.2 74.5 43.1

-I-no

TABLE 31

DIET ANALYSIS (meq/24 Iours)

'Subject Day of Study Sodium Potassium Calcium

8G 173.2 92.7 51.7 10 6B 174.7 93.0 48.2

22B 176.3 93,6 49.0 BR 180.1 94.8 47.9

1C 171.9 90.4 50.8 11 7B 172.8 91.0 51.0

21B 173.7 -92.0 56.0 10R 169.4 86.2 52.5

JC 165.2 77.9 54.4 8B22B

167.3168.1

73.374.3

52.053.9

IR 163.4 72.9 53.4

1C 165.3 79.1' 27.5

13 7C 171.2 78.3 30.3 14B 170.5. 77.2 29.9 28B 178.1 79.7 27.8

1C 194.0 81.3 50.8

14 6C13B

-190.6200.2

78.1 77.9

49.8 50.5

27B 186.7 84.1 50.0

1C 166.9 688 33.9

15 13C 173.9 73.6 35.3 13B 169.9 70.0 33.8 27B 174.0 70.4 33.5

10 162.5 95.8 39.5

16 14C 156.0 97.5 40.3 14B 162.5 96.1 41.3 28B 160.1 96.8 39.1

7C 177.6 89.8 48.9

17 7B,17B

181.8 177.9

92.0 88.8

50.4 50.5

IR 176.8 90.8 50.5

60 175.9 92.0 :38.2 6B,

16B 174.7-177.7

91.891,8

35.738.7

28B 167.1 87.7 39.8

TABLE 31

DIET ANALYSIS

(meq124 Hours)

Subject- Day of Study sodium Potassium Calcium

10 169.5 85.5 44.A

19 13C 167.0 86.6 43.0

21B 169.5 83.9 42.1

8R 169.7 85.7 44.9

2B 157.3 91.3 42.7

21 10B 161.9 -90.1 43.4 24B 163.1 92.4 41.8

7R 155.6 .88.9 41.2

IB 168.8 70.3 41.4

OB24B

168.8165.4

71.171.7

41.845.6

6R 163.7 70.3 38.8

7C 164.9 82.0 50.5

23 7B 165.9 82.0 49.0 21B 169.7 80.9 48.3 27B 165.4 78.0 48.3

1C 181.6 100M1 58.4 24 14C 182.7 99.4 49.4

14B 179.9 100.4 60.0

7R 173.4 96.5 58.7

102

TABLE 32

AVERAGE DAILY STOOL CALCIUM BY WEEK OF STUDY (meq/24 hrs)

Week of Study


1 2 1 2 3 4 1 2

1 46.7 38.7 38.6 44.4 38.6 50.6 42.5 44.8

2 32,8 38,0 35.7 38.5 35.9 54.6 45.6 37.0

3 37.9 33.7 29.0 35.8 46.3 47.1 61.4 45.5

4 56.1 36.6 35.3 46.9 48-2 42.7 55.7 47.7

5 38.8 34,5 44.8 48.9 53.2 41.5 57°9 58.9

6 19.4 20.2 21.5 39.6 46.1 48.5 40.2 41.1

7 32.1 20.9 60,2 35.4 35.7 88.2 58.3 35.6

8 33.6 30.9 37.3 43°3 48.1 45.6 44.2 40.8

9 34,5 33,9 37.3 37,4 Z1.2 32,9 44.3 33.1

10 3.6.6 23.9 31,2 30.1 30.4 32.3 42.2 33.3

11 40.3 44.6 45.9 44.5 36.2 46.2 44.4 42.4

12 42.7 42,2 54.6 42.6 43.7 48.8 37.4 40.6

13 23.8 26.3 37.0 23.7 32.6 40.9 28.4 26.5

14 39.0 43.2 46.7 39.3 46,7 47.3 58.3 41.2

16 13.9 28.4 31.8 34.6 30,1 45.9 22.9 27.5

17 28.9 28.9 30.6 54.6 40.2 28,4 47.0 44.1

18 34,2 26.1 25.2 33.8 24.3 24,1 23.9 27.9

19 34.6 36.3 21.3 32,1 31.3 33.1 44.0 35.0

21 44,1 34.8 40.2 38.9 40.0 35.9 38,9 36.7

22 27.5 26.5 29.5 25.5 41.4 35.6 28.5 36.6

Mean 34.9 32.4 36.7 37.0 39.5 43.5 4303 38.8

SE (95%: ±4,5 ±3.4 ±4.7 ±3.6 -±3.5 ±6.2 ±5.3 ±3.6

<.1 <.1 <.1 <.025 <.025 <.025

444,

TABLE 33

OF STUDYAVERAGE DAILY CALCIUi BALANCE BY WEEK (meqI24 hrs)

Week of Study


1 2 i 2 3 4 1 2

1 -11o3 - 0.5 - 4.8 - 7.0 2 8.6 -17.6 - 5,2 4.1

2 1,2 - 2.8 -2,5 - 6J1 5.5 -16.2 - 8.7 2.2

3 1.9 5.8 9.0 0.7 -11,3 -11.1 -21.7 - 4.0

4 5

-11.7 - 3.8

7,5 0.1

6.5 -11.

- 6.0 -180

-12.7 -22.8

- 6.2 -11.5

-11.2 -25,2

- 2.9 -23.4

6 5,0 2,0 - 5,3 -27.5 -32.6 -34.0 -19,3 -17.4

7 7.4 17.5 -21.3 4.0 2,3 -51.6 -19.9 4.5

8 6.7 8,5 2.6 - 7,2 -14.1 -12.9 - 7.3 - 0.5

9 2.1 2.5 - 1.7 - 0,9 - 5.9 2.2 - 8,0 3°6

10 0.1 12,6 2,4 2.2 1.0 - 0.8 - 6.5 4.1

11 - 1o7 - 5.5 -11.5 -11.1 - 2.1 -11.0 - 6.6 - 2.9

12 -1.8 - 1.0 -16.1 - 4.9 - 7.0 -11,8 2.5 0.3

13 - 3.6 - 8,0 -17.8 - 9.8 -16.4 -26.6 -10,6 - 5,1

14 001 - 5.5 -116 - - 6,2 -12.1 -17.4 -21.4 - 0.7

16 13.0 -. 2,3 -11.9 -14,8 -14.2 -31.6 0.8 0,3

17 9.9 10.2 6,5 -16.8 - 6,4 8,5 - 9.5 - 4.3

18 - 1.6 6.1 5.6 - 3.9 5,8 3.4 5.8 3,6

19 - 2.3 - 3.9 7.4 - 5.9 --6,8 - 8.2 -11.9 1.0

21 - 8.6 - 0.2 - 5,5 - 6.7 - 8.5 - 4.9 - 4.0 - 0.6

22 - 1.2 - 0.3 -10.0 - 6,8 -23.3 -17.2 - 2,3 - 5.4

Mean 0.0 2,1 - 4.6 - 7.6 -10.1 -13,8 - 9.5 - 2.6

SE (95%) ± 30 ± 3.1 ± 4.3 ± 3,5 ± 4.3 ± 6.6 ± 4.0 ± 3.2

p <.025 <.001 <.001 <.001 <.001 <.2

104

Th31EZSfl

AIDOSTERONE EXCRETION SIMMARY (pgr/24 Hra)

Ambulant Bodreot Recovery

Sub ct Day of Study 7 8 13 14 1 3 7 8 15 16 21 22 27 1 2 6 11 12

1 2 3 4 5

.6 7 8 9

10 11 12 13 14 15 16 17 18 19 21 22 23 24

11.0 16.0 17.0 23.0 9.0 6.0

13.0 9.0

11.0 11.0 21.0 19.0 5.0 7.0

17.0 17.0 11.0 14.0 21.0 11.0 19.0 25.6 14.6

10.0 14.5 8.5

15.0 7.5 6.5

12.5 6.5

14.0 13.5 22.0 6.5 7.5

13.5 13.5 9.0 9.5

12.5 14.5 6.5 7.0

18.0 14.7

10.0 14.5 8.5

15.0 7.5 6.5

12.5 6.5

14.0 13.5 22.0 6.5 7.5

'13.5 13.5 9.0 9.5

12.5 14.5 6.5 7.0

18.0 19.9

11.0 13.0 13.0 16.0 9.5 5.5

12.0 15.0 7.5 9.5

24.0 7.0

12.0 12.0 13.0 14.0 13.0 11.0 13.0 8.0

14.0 15.1 19.9

11.0 13.0 13.0 16.0 9.5 5.5

18.0 8.0 7.5

11.5 20.0 11.0 7.5

11.0 14.0 10.0 11.5 13.0 13.0 12.0 40.5 14.9 17.1

6.0 11.0 7.0 10.0 9.0 14.0

16.0 23.0 6.0 8.0 6.0 6.0 9.0 9.0 9.0 14.0

14.0 10.0 12.0 14.0 14,0 20.0 7.0 10.0 5.0 14.0

14.0 12.0 19.0 15.0 8.0 14.0 9.0 10.0 7.0 10.0

14.0 11.0 9.0 14.0

15.0 15.0 11.5 20.8 14.9 19.0

11 12.5 15.0 16.5 6.5

10.0 8.5

11.0 12.0 13:5 17.0 6.0

10.5 10.0 19.5 12.0 10.0 7.5

12.5 12.0 14.5 14.9 23.9

11.5 11.5 11.5 12.5 14.5 14.5 15.0 16.5 26.5 26.5 6.5 9.0

10.0 7.0' 8.5 9.5 9.5

11.0 12.5 12.5 12.0 10.0 10.0 13.5 26.0 26.0 17.0 21.5 21.5 6.0

10.5 13.5 13.5 10.0 10.0 10.0 19.5 23.5 23.5 12.0 14.5 14.5 10.0 9.5 9.5 7.5 9.5 9.5

12.5 12.0 12.0 8.0 14.5 10.0 16.0 14.9 14.6 14.7 24.0* 19.6 19.6

13.0 13.5 8.0

6.0 12,5 9.0 9.5 9.5

21.5 10.0 9.5

13.5 20.0 12.0 11.0 9.0

16.5 11.5 13.5 15.7 26.4

13.0 13.5 8.0

27.0

6.0 12.5 9.0 9.5 9.5

21.5 10.0 9.5

13.5 20.0 12.0 11.0 9.0

16.5 11.5 13.5 15.8 26.4

10.5 26.0 6.0 8.0 7.0

13.0 12.0 17.0 28.0 12.0 12.0 8.0

23.0 11.0 10.0 7.0

19.0 10.0 16.0 18.2 26.8

21.0 14.0 30.0

7.0 7.0

17.0 17.0 13.0 20.0 29.0 17.0 20.0 21.0 23.0 14.0 12.0 13.0 26.0 14.0 63.5 26.7 34.6

12.0 11.0 17.0 9.0 16.0 14.0

9.0 11.0 4.0 10.0 7.0 6.0 12.0

12.0 11.0 19.0 8.0 18.0 18,0 30.0 18.0 10.0 6.0 12.0 7.0 14.0 8.0 23.0 29.0 11.0 I1.0 13.0 7.0 14.0 9.0 14.0 15.0 13.0 24.0 33.0 18.0 21.3--14.4 21.8 14.8

11.5 7.5

11.5 11.5 8.0 6.5 6.0 8.5 8.0

24.0 18.0 9.0 6.0

13.0 19.0 7.5 4.5 "8.5

12.0 9.0 7.0

22.7 15.8

8.5 9.5

11.5 11.5 8.0 6.5 6.0 8.5 8.0

24.0 18.0 9.0 6.0

13.0 19.0 7.5 4.5 8.5

12.0 9.0 7.0

22.7 15.8

TABLE 35

AVERAGE DAILY ALDOSTERONE EXCRETION BY WEEK OF STUDY (ugm/24 Ers)

Ambulant Bedrest Recovery

Subject 1 2 Mean 1 2 3 4 1 2

1 10.50 10.67 10.58 9,50 11.50 12.00 13.00 14.67- 10.00 2 15.25 13.50 14.38 9.83 12.50 14.17 13.50 13.33 8.50 3 12.75 11.50 12.13 12.67 15.00 8.00 9.25 -20.00 11.50 4 19.00 15.67 17.33 18.50 16.50 26.50 26.50 9.00 11.50 5 - 8.25 8.83 8.54 6.93 6.50 9.00 6.00 '7.33 8.00 6 -6.25 .5.83 6.04 7.33 10.00 6.50 7.00 .8.00 -6.50 -7 12.75 14.17 13.46 8.83 8.50 10.50 9.75 -11.67 6.00 8 - 7.751 9.83 8.79 11.33 11.00 11.33 11.00 :13.33 -- 8.50

.9 .12.50 9.67 11.08 12.00 12.00 9.83 10.75 13.33 8.00 10 -12.25 11.50 11.88 13.17 13.50 20.50 13.25 18.67--24.00 1i 21.50 -22.00 21.75 17.00 '17.00. 21.50 24.75 25.67 -18.00 12 .12.75 8.17 10.46 7.67 6.00 10.00 11.00 -II°00 9.00 13- ,<6.25 . 9.00 7.63 -9.83 10.50 12.17 10.75 '13.00- .6.0014 10.25- 12.17 11.21 12.00 10.00 11.17 10.75 .14.33 13.00 15 L5.2i''13.50 14.38 17.83 19.50 22.33 21.50 -25.00 1900 16. 13.00 11,00 12.00 11.33 12.00 13.67 11.50 -12.00- .7.50 17 10.25 11.33 10.79 9.67 10.00 10.00 10.50 "10.67 4.50 18 13.25 12,17 12.71 8.17 7.50 9.33 8.00 12-00- 8.50 19 .17..75 13.50 15.63 12.50 12.50 16.50 17.75 .18.33 12.00. 21 .8-75 - 8.83 8.79 11.67 .12.00 10.50 10.75 -17'.00-.9.00" 22. 13.00 .20.50 16.75 14.83 14.50 13.17 14.75 38.17- .7.00. 23 21.80 16.00 18,90 15.73 14.90 15.00 17.00 -20.80. 22,70 24 14.65 18.97 16.81 19.27 24.00 21.87 26.60 23.73 15.80

Mean 12.86 12.54 12.06 12.50 13.72 13.72 "'16.13 11.07

SE. 95% .1.85-.>1.72 1.58 1.80 2,30 2.57 1.3.07 '.2.32

-3-M

TABLE 37

FLUID BALANCE SUI-IhRY (ml/24 Hi-rs>

Subjec

Day of Study 19 20 21 22 23 "24

C i 271 566 121 761 226 136 C 2 442 927 205 1545 630 -' 75 C 3 465 645 880 1075 505 1030 C 4 145 275 515 953 415 755 C 5 105 655 330 1400 435 405 C 6 360 360 - 35 1150 120 390 C 7 460 735 400 880 685 10 C 8 -250 535 230 435 335 495 C 9 166 296 469 1174 671 776 -CIO 710 730 310 1580 110 270 CI 125 515 -175 1090 640 135 C12 185 1170 -160 590 130 220 C13 165 310 - 15 1130 315 340 014 415- 440 1132 1452 990 840

B 1 545 1220 - 15 150 "-425 -415 B 2 486 201 -114 371 -194 211 B 3 505 940 940 710 165 110 B 4 625 985 -475 510 705 190 B 5 435 840 240 225 390 425 B 6 '380 0 630 440 335 295 B 7 210 80 375 430 325 400 B 8 180 1275 275 445 345 -460 B 9 - 545 150 290 430 545 405 BIO 220 60 435 385 140 150 Bit - 60 765 560 545 370 495 B12 335 555 285 680 435 330 B13 220 1340 325 820 200 85 .B14 591 481 515 295 415 170 BI5 90 830 -265 270 240 240 Bi6 565 1215 906 691 850 - 60 B17 75 350 90 455 785 640 B18 230 500 -150 345 505 5 B19 250 610 280 1115 275 150 B20 270 325 575 185 495 335 B21 290 485 485 265 545 294 B22 575 580 - 35 880 441 120 B23 355 690 510 1583 700 715 B24 305 420 -110 1270 745 410 B25 140 790 1140 -360 555 385 B26 60 345 230 225 155 330

"B27 250 315 20 - 35 395 -185 B28 396 574 6 504 125 440

TABLE 37

FLUID BALANCE SUDNARY (ti/24 Hrs)

Subject

Day of Study 19 20 21 22 23 24

R i 907 - 992 787 1227 1140 1400 R 2 665 990 715 1560 371 489 R 3 395 380 180 625 1610 815 R 4 120 110 470 995 1140 460 R 5 335 570 250 890 625 500 R 6 455 740 1130 1205 555 180 R 7 745 579 91 1081 924 335 R 8 705 705 290 1865 1110 865 R 9 570 685 485 835 200 10 RI0 55 240 525 2095 - 18 660 RII 210 505 940 895 790 755 R12 640 595 540 1500 735 855 R13 260 630 780 1440 400 765 R14 455 700 26 1341 856 339

TABLE 37'

FLUID BAIJNCE SUEARY - (ml/24 Hrs)

Subject 'Day of Study 1 2 3 4 5 6 7 8 9

C 1 593 345 -166 -337 530 -295 309 112 387-C 2 582 109 169 212 720 620 408 775 810 C 3 -197 -436 694 - 38 603 -- 153- 60 1060 655 C 4 222 314 29-- -180 770:. 655 510 490 645 C 5 507 - 26 104 457 775 125 240 765 600 C 6 511- 349 99 -148 685 800 610 5 1530 C 7 602 514 1254 52 965 -430 160 455 495 o 8 - 33 -226 354 142 205. 760 330 -545 325 C 9. 342 301 -536 '132 1008 276 m946 1160 667 'CIO 47 -151 24 -168 1289 -478 260 1180 630 Cli - 13 242 2 -385 180 610 35- 525 695 C12 "192 99 80 202 655 65 1080 - 515 560' C13 292 19 414 -103 235 317 -615 715 64-0 C14" 1022 -149 >559 2 762 -480 380 615: 1770.0 655:

B 1- -358 -181 -441 . -803 445 -317 270- '442. 145 B 2]- 34 364 - -106 250 158 - 67 255 593" 402 B 3 227 -241 174 207 1342 -215 - 45 860 475 B 4 123 515 109 -140 335 215 405 433 430 B 5' -782 149 -316 4178 365 -175 305' 275' 745 B 6 237 14 -121 75 422 230 430 705 680 B 7 277 129 201 32 130 -170 90 615"• 365: .-B 8 .512 229 - 84 :327 . 325 255 365.- 50Q 44.0-.: -B 9 132 - 81 544 -200 790 -340 260 700 405 BI0 - 287 389 54 282 345 155 270- 505- 345, 3II- 712 -191 204 152 370 - 55 330 580 425 B12- 202 659 .239 -108 - 321 127 185 300 95: B13.. 97 -246 124 332 355 230 160 105 785 B14 459 629 229 -270 510 -255 762 1612 1154 B15- '612 -354 - 91 - 7 325 360 130 615' 195] B16 1047 -366 - 21 507 443 943 265 1270 620 B17 542 104 - 61 -398 360 292 290 285 350 B18 307 - 61 -106 122 350 -155 440 520 420 B19 332 - 11 149 642 ,490 280 - 440 - 70 240 B20 447 129 -121 -148 235 -1095 135 515 330 B21 610 517 84 83 530 130 150 865 770. B22- .112 114 - 16 252 .510 - 72 50- 630. -255: B23- '232 199 - 99 - 662 15 222 195. 590'" 435 B24 - 98 264 189 -198 245 -170 165 937 310 B25- 362 .154 44 582 400 305 360- -300 100 B26- -482 429 - 183. 602 475 -345 205.. 380. 295 B27 142 139 159 32 345 255 390 -120 920 B28- 375 162 -131 240 145 218 197 377 . '448

TABLE 37

FLUID BAlANCE SUMMARY (ui/24 rs)

Subject

Day of Study 1 2 3 4 5 6 7 8 9

R I 1057 1179 999 832 860 700 1279 905 803 R 2 260 252 434 667 930 455 415 1300 720 R 3 1002 199 244 532 195 840 620 480 993 R 4 285 -243 522 752 785 -735 -110 445 585 R 5- 822 654 289 -128 358 -195 315 -495 515 R 6 914 369 589 292 735 -'95 615 1150 640 R 7' 225 167 1424 432 - 76 360 402 382 147 R 8" 33 -101 -441 260 610 545 430 50 605 .R 9 832 224 179 225 405 480 640 1165 580

RIO 697 349 -201 527 550 -150 20 1210 760 RII 517 489 369 -191 425 - 45 430 995 620 R12 852 464 -213 257 247 -1§5 440 535 240 R13 862 374 314 532 375 935 1032 1170 495 R14 785' 837 117 682 580 -132 290 242 737

-1-1

TABLE. 3'

FLUID BALANCE SUbR (mil/24 lirs)

ARY

'Subject

Dfay ofStady 10 11 12 13 14 15 16. 17 18-

C 1 367 593 684 395 1005 311 911 291 -100 0 2 420 762 920 95 - 10 875 905 105 845 0 3 -410 512 685 -140 755 595 1060 -130 610 -c4 595 477 780 495 320 1030 1070 265 685 C 5 595 272 595 480 750 1300 740 60 - 55 o 6 245 -527 1040 300 1435 1370 1180 225 920 C 7 210 142 445 200 460 900 1355 30 310 o 8 240 137 1085 436 -349 - 1035 1230 100 565 o 9 252 868 1618 -325 1175 831 261 71. 413 CIO 520 52 465 60 245 750 1545 30 30 CI0 610 407 475 235 805 1355 1190 300 750 C12. 165 - 8 230 -125 "555 1065 455 - 610 "980 C13 415 A71 330 375 855 1660 1575 280 1380 C14 '660 559 767 52 807 1615 1309 130 765.

B 1 -350 -268 -135 370 '55 410 -170 10 205. B 2- 542 -267 798 L-158 283 20 568 -404 -464P B 3 440 237 425 -205 450 215 1035 -1-10 -355 B 4 345 307 597 15 - 270 480 495 235 305 B 5 450 297 '615 80 290 830 760 260. 65 B 6 230 252 340 70 530 315 805 70 - 25 B 7 365 72 615 545 350 1045 910. 115 185: B 8 245, 377 365 140 585 385 155 - 80 -170 B 9 475 247 415 135 220 1100 55- - 80 200 B10. 110 252 675 -200 195 1135 I151 221 190 Bilt 130 212 .565- 405 175 -755 325 .410 125 -1I2. 445 477 425 -120 365 925 1160. -160. 95 B13J 270 662 992' 675 960 530 760 3607 125 B141 389 393 .523 -168 -238 1106 426 236.. -319. B15' 260 '332 25 -440 285 1270 290 165 -260: B16 355 187 855 1135 135 170 990 165 680 B17 410 175 510 -290 590 675 -270 155 385 B18 295 577 635 75 535 310 755 85 7135. B19 483 .602 445 155 180 490 720. 430 365 B20. 5 277 - 870 700 1350 570 250 -230 355. B21' 535 722 885 -300 -155 - 15 245 595- -475 322- 432 392 530 630 1305 1135 475 365- -130 323 320 - 33 470 -360 -335 155 250 60 790 B24: 20 1547 500 80 1155 . 1175 1275. 180.. 325 325 470 502 820 - .410 275 205 259 - 90: 85 B26 610 182 725 285 580 270 365 605 540 B27 460 377 512 125 595 720 850 -120 445

.124 380 523 238 .753 336. 546- - 493, - 97

112

TABLE 37

FLUID BALAECE SUlJARY (ml/24 Hrs)

Day of Study 10 1i 12 13 14 "15 16 17 18

R 1 758 " -182 921 1032 1242 1720 1015 655 1345 R 2 1240 1141 670 1165 1080 1220 615 300 765 R 3 -122 - 58 840 1160 855 1860 860 -150 855 R 4 - 15 532 690 -105 630 1535 1215 210 970 R 5 365 232 855 305 615 720 1312 535 55 R 6 555 442 955 - 95 715 1240 1255 220 350 R 7 192 748 551 318 1063 461 571 286 431 R 8 290 607 760 747 1500 1230 1036 305 800 R 9 190 247 1055 440 1255 1200 770 - 10 530 RIO -405 392 1510 1015 350 1275 1455 575 505 RII 477 83 822 - 30 1270 7-80 -185 -375- 145 R12 535 427 375 1280 1650 395 480 -630 R13 438 477 1140 850 1878 555 430 565 R14 397 735 1143 898 1789 1286 86 401

113

TABLE 38

AVERAGE DAILY FLUID BALANCE BY WEEK OF STUDY (ml)


Week 1 2, Mean i 2 3 4 1 2

1 459 264 362 .179 343 557 243 652 645 2 167 63 115 107 198 95 209 368 377 3 312 143 228 49 211 -24 86 643 69 4- 3 83 43 -80 74 114 310 483 327 5 721 579 650 457 431 390 305 541 456 6 233 276 254 -71 17 108 59 400 205 7 328 108 218 244. 333 264 223 505 469 8 523 817 670 561 550 571 356 595 767 9 732 596 664 454 521 418 322 629 577

10 406 409 408 232 295 333 313 425 270 11 469 341 405 166 374 410 478 375 424 12 736 710 723 465 566 478 583 783 927 13 301 101 201 131 124 148 201 540 743 14 674 584 629 318 323 417 618 886 1385 16 1032 1081 1057 782 577 426 573 978 758 17 121 217 169 25 130 174 213 '294 213 18 459 698 579 71 ' 8 131 280 682 331 19 321 217 269 455 290 253 297 517 414 21 345 256 301 226 384 274 252 543 512 22 1109 1064 1087 405 514 475 581 1083 1424

Mean 473 430 259 313 301 325 596 '567

SE (95%) ±135 ±149 ±105 ±85 ±80 ±79 ±97 ±169

TABLE 39

PAIRED "t" TEST ANALYSIS FLUID BALANCE

Control Week Bedrest Week Recovery Week

Control Weeks

1 2 i

<.001

2

<.bi

3

<.01

4

<.02

1

<.005

2

<.10

Bedrest Week 4 <.001 <O001

Day IB <.001 <.001

Day 2B

Day IR

Day 2R

<.02 <.5

<0001

<.001

<.001

<.05

TABLE 40

BODY FLUID COMPARTMENTS

Plasma Red Blood Extracellular Total

Subject Day of Study Volume (L)

Volume (L)

Fluid Volume (L)

Body Water (L)

Weight . (kg)

1C 2.429 1.862 18.52 39.91 64.480

11C 2.996 1.685 13.80 37.42 65.130

2B 1.525 15.46 40.98 65.545

4B 2.613 1.615 16.35 37.51 64.190

143 2.140 1.741 15.88 64.245

21B 2.577 1.798 16.51 64.270

28B 2.796 1.752 15.97 42.Od 64.595

2R 2.479 i.699 14.78 42.37 64.785,

4IR 2.661 1.704 18.28 33.66 64.620

7R 2.802 2.478 15.37 40.11 64.820

14R 2.821 1.789 16.81 40.74 65.460

1C 2.376 1.880 14.14 3P.96 64.880

1IC 2.528 13.23 34.47 64.810

2B 1.524 14.45 38.64 64.185

43 143

2.403 2.137

1,837 1.682

13.77 13.25

37.75 63.730 63.420

2 21B 2.372 1.692 13.16 63.480

28B 1.954 2.620 12.67 34.77 63.565

2R 2.324 1.653 14.86 63.850

4R 2.433 1.545 17.34 37.74 63.825

7R 2.421 1.308 13.31 39.14 63.640

14R 2.493 1.673 13.57 34.89 64.010

TABLE 40

BODY FLUID COMPARTI'ANTS

Subject

3

4

Day of Study

1C IIC 2B 4B 14B 21B 28B 2R 4R 14R

IC liC 2B 4B 14B 21B 28B 9R

15R

Plasma Volume (L)

2.021 2.149 1.965 2.004 1.886 1.916 1.960 2.505 2.263 2.284

2.652 2.727 2.397 2.297 2.507 2.395 2.310 2.840 2.925

Red Blood Volume (L)

1.520 1.737 1.517 1.383 1.484 1.525 2.121 1.201 1.321

2.016

1.956 2.006 1.860

1.603 1.648

Extracellular Fluid Volume

(t)

16.55 14.41 15.50 16.05 12.97 15.53 14.68 16.06 16.53 15.86

18.31 18.21 18.44 17.60 17.45 16.4.9 17.82 18.70 17.52

Total Body Water

(L)

36.85

37.02 37.30 34.80 34.8. 36.77 35.83 35.6L 37.12

46.22 41.14 48.88 41.35 42.03 42.64 44.68-43.42 49.96

Weight (kg)

64.995 65. 885

66.175 66.855 66.605 67.325 67.715 67.243 67.745

72.480 72.170 72.280 71.620 71.430 70.820 70.710 71.745 71.380

*4

TABLE 40


Plasma Red Blood Extracellular Total Subject Day of Study Volume Volume Fluid Volume Body Water Weight

(L) (L) (L) (L) (kg)

2C 2.040 1.783 14253 36.42 58.220 10C 1.850 1.852 13.37 35.88 58.340 2B 2.081 1.803 35.40 58.140

16B 2.574 1.738 15.30 34.78 58.010 28B 1.976 1.708 14.17 27.78 57.520 7R 1.939 1.658 13.95 34.28 57.650

14R 2.402 1.761 14.28 36,38 57.210

2C 2.054 1.746 16.5 39.52 62.025

10C 2.461 1.722 15.6 38.72 62.070 2B 2.232 1.755 40.72 61. 710

16B 2.513 1.708 15.0 39.61 61.760 28B 1.516 1.612 16.2 40.09 60.610 7R 2.116 1.637 16.3 42.04 60.680

14R 2.425 1.673 16.6 45.74 61.070

1C 2.599 13.41 34.81 60.255 9C 2.680 13.41 35.76 60.350 2B 2,569 1.423 13.54 35.25 60.580

14B 2.126 1.274 14.00 33.11 60.220 28B 2.480 1.354 13.29 36.11 60.600 7R 2.768 1,320 13.97 34.42 60.510

14R 2.826 1.300 13.72 32.96 60.780

TABLE 40



1C 9C

8 2B 14B 28B 7R

14R

1C 9C 2B

14B

28B 7R

14R

1C 9C 2B

10 14B

28B 7R

14R


(L)

16.25 16.18 15.39 17.10 15.21 16.46 16.99

16.19 17.06 16.17 16.56 16.1.1 16.67 16.67

16.61 16.89 16.40 16.61 17.24 17.76 17.02

Total Body Water Weight

(L) (kg)

43.80 82.560 81.860

44.03 82.310 48.47 82.930 41.38 82.510 43.96 83.i70 42,96 83.230

40.94 68.700 40.46 68.230 40.11 67.805 40.40 67.610 40.07 67.230 41.61 67.550 41.01 66.710

44.36 85.420 44.73 85.450" 46.43 85.315 46.73 86.270 45.83 86.580 46.19 86.810 47.43 87.010

Plasma Volume (L)

2.851 2.878 2.769 2.952 .2.997 3.394 3,368

3.104 3.230 3.016 2.915

2.936 3.174 3.079

2.867 2.880 2.641 2.768 2.802 2.985 2.925

Red Blood Volumd (L)

1.582

1.543 1.534 1.490

2.063 1.992 2.029 1.914

1.841 1.751 1.774

1.'821 1.754 1.719 1.691 1.686 1.587 1.596

I . (I J'p

TABLE 40"



1C 9C 2B

11 14B

28B 7R

14R

10 9C 2B

12 14B

28B 7R

14R

2C 9C 2B

13 14B

28B 7R

14R


(L)

15.53 15.66 14.33 14.80 15.27 15.59 14.95

14.81 15.79 14.90 14.78 14.76 15.78 14.57

14.85 14.92 15.31 14.53

14.31

15.13


(L) (kg)

44.72 68.300 43.07 68.190 44.39 67.990 43.01 67.740 41.56 67.900 41.13 67.740 42.34 67.560

42.83 64.176 42.85 64..636 41.37 64.186 43.40 64.866 43.76 64.876 45.74 65.341 41.30 64.350

42.30 69.178 44.17 69.508 44.07 69.353 43.89 69.258 41.79 68.308 44.85 69.268 48.45 '69.0O8

Plasma Volume (L)

2.768 2.811 2.753 2.782

2.746 3.277 3,346

2.729 2.880 2.580 2.720 2.724 3.499 3.236

3.370 3.282 3.035 2.729

2.823 3.385 3.421


1.866 1.825 1.827 1.740 1.696 1.711 1.698

1.637 1.607 1.507 1.459 1.444 1.426 1.375

1.745 1.679 1.693 1.619

1.616 1.570 1.591

TABLE 40

'ODY FLUID COMPARTMENT

Plasma Red Blood Extracellular Total

Subject Day of Study Volume (L)

Volume (L)

Fluid Volume (L)

Body Water (L)

W&ight (kg)'

2C 3.393 1.900 16.70 49.50 70.939

9C 3.076 1.879 17.44, 50.81 69.969

14 2B

14B 3.243 2.825

1.869 1.830

16.61 16.14

50.82 52.26

70.619 70.509

28B 2.876 1.776 16.41 50.16 69.799

7R 3.314 1.732 54.34 69.869

14R 3.252 1.7.11 16.52 52.92 69.119

IC 3.327 2.117 18.13 48.85 82.210

9C 3.448 2.033 18.16 47.42 82.210

15 2B 14B

3.064 3.020

1.845 1,824

18.43 18.10

46.82 45.96

81.460 79.860

28B 2.804 1.842 18.10 44.56 80.500

7R 3.341 1.765 19.27 45.33 81-.180

1C 2.978 1.843 14.14 A3.58 66.644

9C 3.178 1.869 14.93 44.30 66.564

2B 2.944 1.826 14.13 41.23 65.114 16 14B 2,855 1-.695 14.31 43.19 65.594

28B 2.958 1.619 14.65 40.41 65.304

7R 3.348 1.594 14.67 41.88 64.754

14K 3.509 1.614 13.91 42.13 64.239

TABLE 40

BODY FLUID COMPARTMNTS

Subject

17

18

19

N N

Day of Study

1C 90 2B

14B

28B

7R' 14R

io 9C 2B 14B

28B 7R

14R

1C 9C 2B

14B

28B 7R

14R

Plasma Volume (L)

.2.520 2.708 2.273 2.195

2.237 2°678 2.495

.3.418 3.526 3.218 3.016

3.008 3.417 3.214

2.780 2.782 -2.943 2.643

2.695 2.898 9 119


1.358 1.278 1.234 1.280

1.278 1.225 1.234

2.069 2.061 2.031 2.060

1.989 1.935 1.944

1.921 1.840 1.786 1.798

1.738 1.670 1.706


(L)

12.59 12.64 12.07 11.92

12.42 12.62 12.20

16.97 16.72 16.70 16.08

15.97 16.50 16.56

15.30 14.62 14.85 14.63

14.80 15.08 14.91


(L) (kg)

35.18 54.850 35.46 54.950 32.84 55.140 31.94 55.520 32.36 55.460 34.21 55.250 34.05 55.450

44.59 70.530 43.79 70.380 41.83 70.160 42.03 69.580 40.39 69.520 42.62 69.120 41.73 69.650

41.33 64.990 39.77 64.530 39.5z 64.270 38.36 '64.590 38.26 64.790 38.72 64.530 39.26 .65.070

TABLE 40


_-sma Red Blood Extracellular Total Subject Day of Study Volume Volume Fluid Volume Body Water Weight

(L) (L) (L) (L) (kg)

IC 3.130 2.022 18.49 50.80 79.290

9C 3.396 2.003 18.59 49.33 79.110 2B 3.330 2,041 18.30 49.60 79.840 B14 3.123 1.951 17.84 48.23 78.070

28B 3.136 1.929 17.83 48.44 77.810 7R 3.306 1.851 17.88 47.73 78.370

15R 3.420 1.850 18.33 47.48 78.740

1C 3.035 1.484 14.48 37.35 66.550 9C 2.961 1.450 14.46 35.98 66.740 2B 2.906 1.412 14.32 36.30 66.400

21 16B 2.719 1.352 13.70 35.78 66.170 28B 2.910 1.294 14.35 36.01 66.829 7R 3.058 1.294 15.04 35.69 67.059

14R 3.325 1.255 14.25 37.12 67.657

IC 3.312 2.424 17.62 46.34 83.710 9C 3.470 2.388 17.34 47.20 82.930 2B 3.067 2.320 16.91 46.40 82.320

22 B/ji3 2.955 2.229 16.05 45.82 81.400

28B 2.934 2.103 15.76 45.80 80.605

7R 3.443 2.078 17.59 46.81 81.815

14R 3.491 2.136 17.64 45.75 .81.075

TABLE 40


Subject Plasma Volume (L)

Red Blooc Volume (L)


(L)

Total 3ody Water

(L) WeighL (kg)

1C 9C 2B

22B 2R

14R 16R

3.534 3.611 3.466 3.044 3.202 3.425

1.872 1.845 1.860 1.801 1.669 1.787

18.21 18.26 17.33 16.96 16.93

17.70

49.71 49.20 48.47 47.49 46.97 47.94

73.454 73.799 73.209 71.279 71.189 72.639 72.939

24

1C 9C

2B 21B 2R 14R

3.194 3.116

3,035 2.900 3.089 3.192

1.911 2.252

1.864 1.887 1.760 1.823

16.54 15.70 16.22 14.79 16.26 16.10

48.01 48.38 48.42 46.46 47.39 48.21 -

74.111 73.706 73.586 73.986 74.126 74.701

'TA13LE 4:

BODY FLUID 'CbNPARTME And

WEIGHT (Kg)

GROUP MEANS

' TS'(L)

Ambulant Bedrest Recovery

Plasma Volume

n 15

Mean

SE

Day 1

2.990

±.163

9 , I I

3.049

±.157

2

2.886

±.161

14

2.775

±.129

28

2.817

±.124

7

3.196

±.144

14

3.18

±.163

E.C.F.V.

n = 13

Mean

SE

15.57

±1.02

15.71

±1.01

15.23

±1.00

15.26

± .98

15.20

± .88

15.82

+ .94

15.52

±1.09

Red Cell Mass Mean 1.845 1.813 1.790 1.738 1.689 1.648 1.661

n = 15 SE ±.142 ±.146. ±.150 ±.139 ±.129 ±.124 -±.133

T.B.W.

n = 16

Mean

SE

42.16

±2.51

42.02

±2,60

41.64

±2.75

41.41

±3.00

40.55

±3,07

42.01

±3.00

42.25

±2.94

Weight

n = 17

Mean

SE

69.19

-4,o60

69.03

±4.49

68.89

±454

68.84

±4.49

68.60

±4 49

68.80

±4.62

68.70

±4.62

TABLE 42

BODY FLUID COMPARTMENTS AND WEIGHT ;PAIRED "t" TEST ANALYSIS

Bedrest Recovery

Control Mean

Day

Plasma Volume

EOC.F.V.

Red Cell Mass,

T.BoWo

Weight

2

<.005

<.o01

<.02

<.2

<.I

14

<.001

<.I

<.001

<.4

<.1

28

<.001

<0001

<.001

<.o01

<.025

7

<.01

<.1

<.001

<.7

<.2

14

<.025

<.6

<'001

<.9

<.2

Recovery Day 7

Plasma Volume

EoC.F.V. T.B.W.

Weight

<o001

<.005 <.6

<.6

<.001

<.025

<.6

<.9

<.001

<.005

<.005

<.1

Recovery Day 14

Plasma Volume

EoCoF.V. T<B.W.

<.001

<.2 <.4

.5,

<.001

<.1 <.5

<5.

<.001

<.05 <.05

5

'TABLE 43

RESPONSE TO 700 TILT - PLASMA VOLUME ALTERATION

INDIVIDUAL RESULTS

Plasma Volume (L)

-Subject Day of Study

7 014 R 1

.9 C14 R 1

014R 1.

014 - .. i . R 1

014RI

C14.. RI .

014 R 1:,

C14 R 1

014 -

R 1

C14--R I

014--R 1K

019C14 R 1.

020-C14R 1

014-R-2111.

014 R 1.

- 14

l...

C14' 24 R 1

Pre-Tilt

2.678

2.498

2.855 2.980

2.6882.775

2.810 2;730

*2'5502.530

2.970 2:965

3".075 2z788

2.994 2.756

3.095 2.751

2Z596 2.251

3.048 2.720

2,591 2.416

'2.8172.920

-2.6932.910

.3,030 2.642

-3.209

2,733

3,041 2.683

Post-Tilt A (ml)

2.261 417 :1.963 ..535

--2.224 631 C-2.683 297

-2.323 _365-2.295 480

:2.266 :549 T2;406 '324"

"2.120 -29Y1?2.055 475-.

C2,414 556.. 52,623 .-342::'

-2.303 .7727--2259 529'1

C2o368 6269 72.139 617""

P2;624 471' Y-, 2.294 457:'

£2.214 3825" -2.093 158

P2,397 :651' 2 .'2.624 -9-6tS.

:22364 1227: 1.853 -563

2.204 6132.264 -656

-2,-509 -184.

-2.236 -- 674-'

$2,379 -'163,1'-2.176 466

-2.568

i2.703 .30.

-2.544 _49-7-l " 2.299 384

- TABLE 44

RESPONSE TO 70 TILT PLASM VOLUM ALTERATION

GROUP MEANS AND PAIRED "t" TEST ANALYSI Plasma Volume (L)

Pre-Tilt Post-Tilt A (ml) P

fay 140 Mean 2.867 2°358 508 <o001

SE ±.106 ±.072 ±81

Day 19 Mean 2.709 2.292 499 <.001

SE ±.102 ±.127 ±165

P <o3

TABLE 45

ALTERATIONS IN SERUM PROTEINS DURING 700 TILT

Pre-Bedrest Tilt Post-Bedrest Tilt

Subject Pre-Tilt Post-Tilt Pre-Tilt Post-Tilt

TSP ALB. GLOB. TSP ALB GLOB. TSP ALB GLOB TSP ALB. GLOB.

7 7:2 3.7 3.6 8.2 4.0 4.2 7.6 3.7 3.9 7.9 4.0 3.9

9 7.3 4.2 3.1 7.8 4.5 3.3 7.8 4.5 3.3 8.9 4.8 4.1

10 6.5 4.2 2.3 6.9 4.5 2.4 7.3 4.4 2.9 8.9 4.9 4.0

11 7.3 4°2 3.1 8.3 4.1 L.2 7.1 3.7 3.4 7.3 4.0 3.3

12 8.4 4.6 3.8 7.4 4.0 3.4 6.0 3.8 2.2 7.3 4.2 3.1

13 6.0 3.3 2.7 6.9 3.5 3.4 5.8 3.8 2.0 6.3 3.8 2.5

14 6°5 4.0 2.5 7.5 3.7 3.8 6.0 3.9 2.1 6.9 4.0 2.9

15 6.7 4.0 2.7 7.8 3,0 4.8 6.7 2.3 4.4 7.8 4.4 3.4

16 6.7 3.2 3.5 7.8 3.2 4.6 7.1 3.7 3.4 8.0 4.3 3.7

17 6.7 3.8 2.9 7.6 4.9 1.7 6.9 3.6 3.3 7.4 4.8 2.6

18 5.9 4.5 1.4 7.0 5.4 1.6 6.5 3.7 2.8 6.9 5.0 1.9

23 6.3 6.2 1.1 7.3 6.0 1.3 7.5 3.5 4.0 7.8

24 7.1 4.4 2.7 8.0 5.5 2.5 5.4 4.8 0.6 7.1 4.4 2.7

Mean 6.8 4.1 2.7 7.6 4.3 . 3.2 6.7 3.8 2,9 7.6 4.4 3.2

SE (95%) ±.4 ±.3 ±°5 ±.3 ±.5 ±.7 ±.5 ±.4 ±.6 ±45 ±.3 .±.4'


1.C IN 2B 4B

14B 21B

28B2R

4R 7R 14R

LC ItC 2B 4B

14B 2 21B

28B 2R 4R 7R

14R

Creatinine (mg%)

1.02 1.17 1.03 1.23 1.09 1,08 1o061011

1.11 1.08 1.13

°94 .92 .89 .95 .87 .92

.90

.79

.79

.87

.84

TABLE 46

SERUM CEHI STRIES

Sodium Potassium (meq/1) (meq/1)

4.4140.00 4.6146.25 4.3139.25 3.8148.50

144.50 4.3 146.00 4.1

4.5143.00143.00 4.2

144.00 4.5 4.3142.00

145.75 4.2

141.25 4.0 144.25 4.3 143.00 3.9 148o00 3.6 143.50 3.9 142.50 4.8

142.50 4.4 141.50 3.9 142.75 4.2 142.00 4.3

145o25 4.1

Chloride (meq/1)

104.33 99.53 102.17 104.81 104.57 104.09 103.12 103.12

105.54 104.33 105.30

99.50 104.09 100.97 102.40 101.45 102.40 101.93 101019 101.69 103o61

106.74

Calcium (meq/1)

4.72 5.66 5.25 5.30 4.92 4.91 5.12 4.86

5.00 4.79 5.88

4.80 4.91 5.44 6.11 4.55 4.99-4.59 6.38 5.08 5.78

4.99

Osmolality

288 290 293 300 296 294 294 290

293 289 299

289 293 293 300 295 289 291 289 290 290

294

TABLE 46

SERUM CHEMISTRIES

Subject Day of Study Creatinine (mg%)

Sodium (meq/1)

Potassium (meq/i)

Chloride (meq/i)

Calcium (meq/i)

Osmolality

3

IC 120 3B 5B 14B 21B 28B 2R 4R 14R

.97

.98 °94 .97 .91 .85 .86 .88 .86 .88'

143.75 142.50 143.75 142.25 142.25 116.25 140.00 141.75 143.75 144.00

4.7 4.0 4.2 4.6 4.6 3.7 4.5 4.6 4.6 4.7

101.28 100.11 98.93 99.40 98.00 97.98 100.11 99.40

103.18 100.58

5.14 5.14 5°49 5.55 5.43 4.22 5.32 5.10 5.34 5.38

292 290 292 291 294 237 287 290 293 290

N0 11C 2B 4B 14B 21B 28B 9R

16R

.97

.92

.89

.88

.95

.88

.95

.86

.89

141.00 142.00 142.50 138.00. 141.50 141.50 141.50 144.50 145.25

4.2 4.3 4.3 4.2 4.6 4.2 4.3 4.1 3.9

101.98 102,21 98.47 99.17

101.51 100.11 101.28 97.77

101.98

4.97 5.09 5.09 4.59 5.51 5.40 5,15 5.05 4.73

287 285 292 281 290 292 291 284 294

CA,

TABLE 46

SERUM CHEMISTRIES

Subjec Day of Study Creatinine Sodium Potassium Chloride Calcium .Osmolality (mg%) (meq/i) (meq/1) (meq/l) (meq/i)

3.C .77 141.75 4.0 104.99 5.15 292

16. .80 140.00 4,0 101.86 5.06 284 2B .88 140.25 4.5 106.43 6.25 290

16B °83 138.25 4.2 101.86 5.06 285 28B .80 139.50 3.9 101.38 5.18 287 7R .81 141.50 4.0 104.27 5.00 285

14R .72 137.75 3.9 *104.51 5.12 287

3C 080 142.25 4.2 108.12 6.14 292 10C .80 141.50 4.3 105.71 6.23 293 6 2B .80 141.75 4.4 105.47 5.00 289

6 16B .89 140.25 4.6 100.90 6.60 289

28B .83 142.75 4.3 104.27 6.59 291 7R 088 142.00 4.3 109.80 6.18 288

14R .78 138.25 4.0 105.95 5.73 287

i. 075 139.25 4.0 110.85 5.06 287

9C. .79 143.75 4.0 110o35 5.01 293 2B .76 141.25 3.9 104.87 5.05 289

143 28B-

.74

.81 142.25 4.0 141.75 4°0

104.12 108.36

5.02 4.86

290 292

7R .69 139o25 3.8 106.61 5.20 285

14R .72 137.25 3.8 107.61 5.13 282

1W

TABLE 46

SERUM CHEMISTRIES

Subject Day of Study Creatinine Sodium Potassium Chloride Calcium Osmolality (mg%) (meq/1) (meq/1) (meq/1) (meq/1)

LC .82 142.00 4.1 104.12 5.47 289 90 .79 146.25 4.1 108.11 5.01 294

8 2B

14B ,.78 .81

147.50 143.50

4.4 4.2

99.39 105.12

5.16 5.31

290 291

28B .75 141.25 4.0 105.12 5.59 288 7R .71 143.25 4.1 108.61 5.33 292

14R .75 142.75 4.2 109.35 5.26 293

1C .77 142.00 4.2 101.86 4.95 293 9C .83 142.75 4.0 103.05 4.78 291 2B .70 140.25 4.1 100.91 4.83 287

14B .73 140.75 4.0 101.15 4.93 290 28B .77 141.75 4.0 105.20 5.16 290 7R .70 141.50 4.0 102.58 4.85 291 14R .70 140.50 3.9 101.86 4.99 285

1C °88 141.75 4.3 100.20 5.14 290 9C .92 143.50 3.9 102.58 4.97 290 2B .91 142.00 4.4 100.91 4.93 291

10 14B .92 14125 4,2 102.34 5.00 287 28B .91 143.00 4.4 102.10 4.85 289 7R .84 142.50 4,2 104.96 4.60 288

14R .92 141.50 3.9 101.15 4.95 286

'iTABLE 46

SERUM CHEMISTRIES I

Subject Day oi Study Creatiiine Sodium Potassiun- Chloride Calcium Osmo'Ility S y(mg%) (meq/l) (mnq/ly (meq/.1) (meq/l)

1C .79 142.00 403 101.69 5.31 298 90 .77 144.25 4°0 100.52 5.16 302 2B .70 140.75 4.1 104.28 5.75 295

'14B .68 140.75 3.9 102.40 5.70 295 28B .70 142.00 4.0 104.99 5.64 299 7R .62 142.00 4.0 IQ4.99 5.39 297 14R .68 142.75 4.2- 105.69 6.01 3Q0

10 .83 .142.50 4o0 102.87 5.55 297 90 .80 144.00 3.8 106.64 5.19 297

1 2B .82 141.50 3.9 102.63 5.72 294 12 14B .82 142.75. 3.7 103.58 5.81 296

28B o82 143.50 3.7 104.28 5.85 298 7R .83 141.75 3,7 105.22 6.02 292

14R .85 142.00 3.9 99.81 4.97 294

20 .97 147.75 4.3 108.34 5.13 308 90 144.50 4.1 106.19 5.01 .11 12B .94 146.00 4.2 107.62 5.57 299

13 14B 1,04 146.00 4.3 103.34 6.02 306 28B .87 144 15a, 4.3 101.91 5.69 299 7R .94 145.25 4.4 105.72 5.42 303

14R .94 I 5. ,j 4.4 105.00 5.14 304

;TABL 46

SERUM CHEMISTRIES

Subject Day of.Study Creatinine (mg%) %

Sodium (meq/l)

Pot~ssium (neq/l)---

Chloride (meq/1)

Calcium (meq/l)

Osmolality

14

20 9C 2B 14B 28B 7R 14R

1.01 1.00 1000 .91

1Q01 .99

1.01

143.25 143.00 143.50 145.50 141.25 142.25 141.59

4.2 4,4 4.2 4,4 3.8 4.0

. 410-

105.95 102.86 106.67 104.53 104.76 104.29 106.43

5.59 5.71 5.22 5.93 5.56 5.24 5.08

298 299 302 305 '296 300 299

15

IC 9C 2B 14B

28B 7R

.83

.88 ,84 77 .86 .86

143o25 144.50 142.00 142.25 142,50 145.50

4.1 4.1 .4.4 3.9 4.5 4,4

107.06 109.93 107.54 100.11 103,46 105.38

4.67 5,49 5.12 4.79 5,43 5.52.

303 303 300. 300 304 306

C.

16

IC 9C

,!2B 14B 28B 7R 14R

.95 1.00 "1o02 .89

1.92 .91 .95

.145.25 144.50 141.50 139.5Q 14242 144025 42.5.p.

4,1 4,2 4.5 307 4.2 3°9

,3.7

107.78 107.78 104.90 105.62 109.21 106.10 107.30

5,24 5.18 5,32 4.92 5.45 5.19 4.87

305 302 302 296 306 308 299

SERUM CHEMISTRIES

Subject- 'Day of Study ' Creatinine Sodium Potasium Chloide Calcium Osmolality - (mg%) (meq/t) (meqt1)_. (meq/1) (meq/1)

IC .89 142.25 4.2 103.37 4.78 300 90 1.00 150.75 4.1 107.22 5.43 296

17 2B .86 148.25 4.7 101.93 5.68 310 14B .92 146.00 4.7 101.69 5.35 291 28B .94 144.75 4.5 101.45 5.17 295 7R .92 147.50 4.1 105.78 5.81 287 14R .94 140.25 4.5 102.65 5.11 310

1C .97 147.75 3.9 106.98 5.23 285 9C .89 145.25 4.0 102.65 5.54 297 2B .94 149.00 4.2 107.46 5.15 293

18 14B . 1.02 147.75 3.9 106.50 5.24 292

28B o91 148.25 3.9 104,32 5.36 .295 7R .88 150.75. 4.3 104o81 5.18 .293

14R 1.00 146.25 4,0 102.65 4.96 280

1C .86. 140.25 3.9 99.46 5.16 295 9C .91 137.50 4.1 100,43 4.95 290

* 2B .81 139.75 4.3 104.54 5.22 297 19 14B .83 140.75 4.4 104.79 5.15 296

28B 89 140.25 4.1 102.12 5.05 297 7R .77 t40.0 4.0 103,09 4,92 294 15R .83 141.50 4.1 98.49 5.16 297

CA

ITABLE 46

SERUM CHEMISTRIES

Subject Day of Study' Cr~atinine Sodium - Potassium Chloride Calcium Osmolality (m) (neq I)--< '(meq/l1)- ... (meq/1) (meq/1)

1C 1.00 141.25 4.1 101.88 4.95 297 9C 1.03 140.75 3;9 102.37 5.35 295 2B 1.03 143.75 4,3 106,24 5.46 297

14B 1.02 143.50 4°2 106.96 5.41 300 28B 1,05 140.75 3.9 102.85 4.66 298 7R 1.03 141,25 3.9 101.64 4,56 295 15R .95 141.00, 4,0 IQ5.27 4.82 295

10 .95 1''139.75 4.3 102.37 5.56. 298 90 1o02 141.75 4°2 100.19 5.59 298

21 2B 098 138.75 .. 403 97.53 5.53 299 16B 1.00 138.25 4,4' 103,82 5.33 297 28B .95 140.75 4.2 101.40 5.81 296 7R .89 143.25 4,3 106.00 5.79 338

14R .92 142.50 4.2 102.12 4.94 313

1C .98 142.25 4.5 106.00 5.31 302, 90 1o03 141.50 4.0 105.51 5.04 312 23 ,98 139,75 4.0 102.61 5.12 298

16B .89 140.75 3.S 104,30 4,98 302 28B .88 140.75 3°9 103,58 5,16 296 7R °88 144,75 3.9 108.17 5.13 302 14R 089 i143,50 4,2 105o75 5.06 300

TABLE 46

SERUM CHEMISTRIES

Subject Day of Study Creatinine Sodium Potassium Chloride Calcium Osm6l&lity (mg%) (meq/l) (meqjlj (meq/1) (meq/1) 3

1C 1.02 138.75 4°4 103.06 4.93 294 9C 1.00 139.00 4.3 1d6.19 4.90 294 2B 1.00 139.25 4.4 103.06 4.95 292

23 22B 1.12 138o50 4.2 105.95 5.02 292 2R 1.00 140.50 4.0 105.71 4.90 294

14R 103 137.75 4.0 104.51 4.73 294

1C .98 147.50 3.8 102.52 5.13 295. 90 1,12 139.25 3,8 99.69 5.27 295

24 2B 1.12 137.50 4:2 98.59 5°22 296 21B 114 137.75 3°9 100.31 5.10 295 2R 098 139,25 3,8 101,53 4.84 293 14R 1000 141.5. 3.6 101.90 5.03 295

TABLE 47

URINE OSMIOLALIrf (mOsm. /1g. 1120)

Day of Study

Subject 1

Day of Study

Subject 2

Day of Study

Subject 3.

Day of study

Subject 4

C i Gil B 2 B 4 B14 B21 B28 R 2 R 4

295 237 306 252 327 204 270 254 298

c C11 B 2 B 4 B14 B21 B28 R 2 R 4

351 322.5 305.5 282.2 353.7 263.8 295.8 302.5 276.0

C 1 C12 B 2 B 4 B14 B21 B28 R 2 R 4

221.1 181.5 228.9 202.1 199 220.1 154.2 244 292

C 1 Cl B 2 B 4 B14 B21 B28 R 9 R14

228 188 263 273 324 233 247

R,7 266 R 7 324.2 R14 270

R14 334 R14 3185

Day of Study

Subject 5

Day of Study

Subject 6

Day of Study

Subject 7

Day of Study

Subject 8

C 3 CI0 B 2 B16 B28 R 7 R14

377 323 292 472 369 371 396

C 3 CI0 B 2 316 B28 R 7 R14

189 210 222 238 379-301 295

C I C 9 t 2 B14 B28 -

R 7 R14

364 284 366 392 474 335 456

C I C 9 B 2 B14 B28 R 7 R14

304 208 28 282 213 222

Day of Study

Subject 9

Day of Study

Subject 10

Day of Study

Subject 11

Day of Study

Subject 12

C 1 C 9 B 2 B14 B28 R 7 R14

554 522 372 374 463 483 539

C 1 C 9 B 2 B14 B28 R 7 R14

402 473 374 345 426 346 420

C I C 9 B 2 B14 B28 R 7 R14

504 453 524 502 400 483 382

C I C 9 B 2 B4 B28 R 7 R14

561 526 536 550 482 534 736

Day'of -Study

Subject 13

bay of Study

Subject 14

Day of Study

Subject 15

Day of Study

Subject 16

0 2 c 9 B 2 B14 B28 R 7

R14

448 361 417 453 556 408

585

C 2 C 9

B 2 B14 B28 R 7

R14

432 561 391 380 459 388

562

C I C 9 B 2 Bl4 B28 R 7

613 477 435 328 376 316

C 1 C 9 B 2 B14 B28 R 7

R14

636 468 528 426 403 403

371

139

TABIL 47

URINE 0S,.40tOIITY (mOsn /kg, E20)

Day of Study

Subject 17

Day of Study -

Subject 18

Day of Study

Subject 19

Day of Study

Subject 21

C 1 C 9 )32 B14' B28 R 7 R14

332 384 394 396 309" 378 336

C 1 0 9 B 2 B14' B28 R 7 R14

394 525 357 530 561 652 541

C 1 C 9 B 2 B14 B28 R 7 R14

857 894 801 871. 799 800 709

C 1 C 9 B 2 B16 B28 R 7 R14

645

627 607 820 601 637 608

*Day of Study

Subject 22

Day of Study

Subject 23

Day of Study

Subject 24

C I 252 C 1 804 C 1 661

C 9 442 0 9 674 C 9 756

B 2 361 B 2 608 B 2 673

B16 576 B21-22 866 B21 613

B28 581 R 2 924 R 2 663-

R 7 602 R14 659 R14 578

R14 672

140r

TABLE 48

OSMOTIC AND FREE WATER CLEARANCE

Subject Day of Study Urine Output 0 Osm. 1120

C £ 1.99 2.04 - .05 C11 2.24 1.831 .41 B 2 1.94 2,03 - .09 B 4 1.98 1.66 .32 B14 1.86 2.05 - .19 B21 2.47 1.71 .76 B28 2.03 1.86 .1.7 R 2 2,11 1.85 .26 R 4 1.85 1.88 -. 03 R 7 1.91 1.76 .15 R14 1.41 1.58 - .17

C 1 1.91 2.32 - .41 C11. 1.99 2.19- - .20 B 2 1.87 1.95 - .08 B 4 1.83 1.72 .11 B14 1.74 2.09 - .35

2 B21 199 1.82 .17 B28 1.73 1.76 - .03 R 2 1.80 1,89 - .09 R 4 2.07 1.97 .10 R 7 1.42 1.59 - .17 R14 1.36 1.48 - .12

C 1 2.81 2.13 .68 012 2.11 1Q32 .79 B 2 1.90 1.49 .41 B 4 2.32 1.61 .80 B14 2.27 1.54 .73

3 B21 2.27 2.11 .16 B28 2.84 1.53 1.31 R 2 1.87 1.57 .30 R 4 1.93 1.92 .01 R14 2.14 1.99 .15

C 1 2.34 1.86 .48 011 2.68 1.77 .91 B 2 1.73 1.56 .17 B 4 2.17 2.11 .06 B14 2.44 2.73 .29

4 B21 2.08 1.66 .42 B28 2.14 1.82 .32 R 9 2.23 R14 2.09

141

TAB E 48

OSMOTIC AND 1REE WATER CLEARANCE

Urine Output

Subject fay of Study (ml/min) HosmnCH 2 0

C 3 1.26 1.63 - .37 Cia 1.03 1.15 - .12 B 2 1.73 1.74 - .01

5 B16 1.33 2.20 .87 328 1.68 2.16 .48 R 7 1.90 2.47 .57 R14 1.50 2,07 .57

C 3 2.68 1.73 .94 CIO 2.51 1.80 .71 B 2 2.43 1.87 .56

6 B16 2.39 1,97 .42 B28 1.82 2,37 .55 R 7 1.93 2.02 - .09 R14 2.38 2.45 - .07

C i 1.86 2.36 - .50 C 9 3.54 3.43 .11 B 2 1.98 2.51 - .53

7 B14 2.14 2.89 - .72' B28 2.09 3.39 -1.30 R 7 2.03 2.39 .36 R14 1.66 1L62 -04

C 1 5.22 C 9 3,37 3.48 .11 B 2 4.11 2.95 -1.16

8 B14 3o81 3.77 .04 B28 4.35 4.26 .09 R 7 3.91" 2,85 1.06 R14 4.43 3.36 1.07

C 1 1.45 2.74 -1o29 C 9 132 2.37 -1.05 B 2 2.10 2.72 - .62

9 B14 1.89 2.44 - .55 328 1.79 2.86 -1.07 R 7 1.81 3,00 -1.19 R14 1.51 2.86 -3.35

142

TABLE 48

OSMOTIC AND FREE WATER CLEARANCE

Subject Day of Study Urine Output

(mi/miu) COsm. C00

i0

C 1 C 9 B 2 B]4 B28 R 7 R14

2.04 1.69 1.74 2.23 2.16 2.49 1.85

2.83 2.76 2.84 268 3.18 2.99 2.72

- .79 -1.07 -140 - .45 -1.02 - .50 - .87

i

C I C 9 B 2 B14 B28 R 7 R14

1.56 1.85 1.67 1.73 1.97 1.43 1.78

2.64 2.78 2.97 2.94 2.64 2.33 2.61

-1.07 - .93 -1.30 -1.21 - .67 - .90 - .83

12

C 1 C 9 B 2 B14 B28 R 7 R14

1.33 1.12 1,26 1.38 1.36 1.25 .82

2.51 1.98 2.30 2,56 2.2b 2.29 2.05

-1.18 - .86 -1.04 -Io18 --1.04 -1.23

13

C 2 C 9 B 2

B14 B23 R-7 R14

1.48 1.85 1.64

1.49 1.35 1.46 .83

2.15

2.29

2.21 2.51 1.99 1.60

- .67

- .65

- .72 -1.16 - .51 - .78

14

C 2 C 9 B 2 B14 B28 R 7 R4

1.67 1-08 2.02 2.17 1.49 1-38 1.22

2.42 2.03 2.62 2.70 2.31 1.78 2.29

- .75 - .95 - .60 - .53 - .82 - .40 -1.07

-43

TABLE 48

0&%,OTiC AND FREE WIATER CLEARANCE

Dy of Study Urine Output(ml/min)

0 osm. c1120

C 1

C 9 B 2 B14 B28 R 7

1.13 1.38 1.88 2.08 2.32 2.00

2.29 2.17 2.73 2.27 2,87 2.07

-1.16 - .79 - .85 - .19

- .55 - .07

c 1 c 9 B 2 B114 B28 R 7 R14

1.17 1.72 1.51 2,20 2.5b, 2.19 1,99

2.44 2.67 2,64 3.17 3,34 2.87 2.47

-1,27 - .95 -1.13 - .97 - .80 - .68 - .48

C 1 o 9 B 2 B14 B28 R 7 R14

2.27 2.11 2.25 2.15 2.60 1.93 2.18

2.51 2.74 2.86 2.93 2,72 2.54 2.36

- .24 - .63 - .61 - .78 - .12 - t61 - .18

18

C 1 o 9 B 2 B114 B28 R 7 R14

2.19 1.69 2.59 1.56 1.61' 1,08 1.49

3.03 2°99 3.11 2.83 3.06 2.40 2.88

- .84 -1.30 - .52 -La2 7

-1.45 -1.32 -1.39

19

o 1

o 9 B 2 B14 B28

R 7 R14

.85

.93

.95

.86

.96

.86 1.06

'2.47 2.87 2.56 2.53 2.58 2.34 2.53

-1.62 -1.94 -1.61 -1.67 -1.62 -1.48 -1.47

TABLE 8

OSMOTIC AND FREE WATER CLEARANCE Urine Output

Subject Day of Study - (rnl/mn) Ostp

C 1 1.27 2.75 C 9 1.17 2.46 B 2 1.36 2.76

21 B16 87 2,La0 B28 1.46 2.87 R 7 1.16 2.07 R14 1.05 2,25

C 1 2°25 1.88 C 9 1.60 2.27 B 2 2,19 2°65

22 B16 1.38 2.63 B28 1.31 2.57 R 7 1.11 2.21 R14 .65 1.46

C 1 1.12 3.06 C 9 1.09 2.50

23 B 2 B21

1,44 .97

3,00 2.88

R 2 .88 2.77 RI4 .96 2.15

C 1 1.33, 2,98 C 9 .84 2.15

24 B 2 1.43 3,25 B21 1.57 3.26 R 2 1.36 3,08 R14 1.41 2.76

C

-1.48 -1.29 -1.40 -1.53

*-1.41 - .91 -1.20

.37 - .67 - .46 -.1.25 -1,26 --1,10

- .81

-1,94 -1.41

-1.56 -1,91 -1.89 -1.19

-1.65 -1.31 -1082 -1.69 -1,72 -1.35

TABLE 49

HEMATOLOGY DATA

Subject Day of Study RBC HGB HCT' WBC MCV MCH MCHC RC

C 1 47 7700 .7 CI 4.62 14.7 43.5 8100 95 31.5 34 .9 B 2 15.7 46 7200 1.6 B 4. 5.24 15.5 46.5 9100 91 31 34 1.2 B14 5.80 16.0 47 8000 81.5 27.5 39 .9 B21 5.70 15.0 47 8400 83 27.5 33.5 1.1 R 2 5.12 13.8 42 7700 82 26.5 33 R 4 4.98 13.5 42 6600 85 27 32.5 .7 R 7 4.77 12.4 38.5 6700 82 26 33 1.5 R14 4.93 14.0 43 7500 89 28.5 33 1.7

C 1 47 6000 .5 1ll 5.52 16.0 45.5 6800 82 29 36 .6 B 2 5.7 16.0 47 6300 " . . 1.5 B 4 5.17 16.9 49 7000 92 33 35 .7 B14 5.87 16.7 47.5 6100 81.5 28.5 35°5 1.2 B21 5.99 16.1 49 7100 83.5 27.5 33 .6 B28 5.55 15.0 46.5 6100 85 27.5 32.5- .7 R 2 5.90 1505 45 72 26 34.5 R 4 4.82 13.0 40 5500 83,5 26.5 32.5 1.0 R 7 5.10 13.3 40.5 5900 81 26.5 33.5 1.7 R14 5.03 14.1 43 5400 86.5 28 33.5 1.5

TABLE 49

HEMATOLOY DATA

Subject Day of Study RBC HGB HCT WBC MCV MCH MCHC RC

C 1 14.7 44 6400 .7 B 4 42.5 9000 .7 B 9 5.15 14.3 43.5 7000 85.5 27.5 33 .6 B31 5.23 14.7 44 6700 85 28 34.5 .6 B21 5.32 14.5 45 6700 85 27 32.5 .4 B28 5.18 14.3 43 9100 84 27.5 33 1.0 R 7 5.36 13.3 40.5 7200 76.5 24.5 33 1.6 R 9 4.74 12.8 38 7700 80.5 26.5 34 .7 RII 4.55 12o4 36 6900 76.5 26 34.5 .9 R14 4.90 13.1 39.5 6000 81 26 33

C 1 4.88 14.3 44.5 8200 92 29.5 33.5 1.2 CI 5.20 14.8 44 7000 85.5 28 33.5 .9 B 2 4.95 15.1 45 6700 91.5 30 33.5 .6 B 4 5.66 14.5 45 7000 80 25.5 32.5 .7

4 B14 5.25 14.9 45 6500 86.5 28 33 .9 B21 46 9000 .8 B28 5.20 14.3 42 8000 82 34 27 1.9 R 7 &.84 13.0 37.5 94-00 78 27 35 1.8 RI3 4.48 12.4 37 7400 . .. 1.7

C 1 5.35 16.4 45.5 5000 86 30.5 36 .8 C 9 5°48 15.7 45.5 4500 84.5 28.5 34.5 1:2

5 B 2 5.34 1"5.5 44.5 5400 84 29 35 1.8 B14 4.46 16.0 45 4600 101 36 36 1.3 B28 5.20 14.9 46 5200 89°5 28.5 32.5 .5 R 7 5.01 14.3 41 4200 82" 35 28.5 2.1 R13 5.31 15.1 3 490O 82 28.5 35.5 2.3

TABLE 49

IMATOLOGY DATA

Subject Day of Study RBC HGB HCT WBC mCV MICH MCIHC RC

C 1 5.60 15.1 47 5700 85 27 32.5 1.1 o 9 5.85 15.3 45 5600 77.5 26 34 .9 B 2 5.57 15.8 46.5 7000 84.5 28 34 1.0

9 B1:4 6.19 14.9 45 6400 73.5 24 33 1,6 B28 6.02 16.8 45 7200 75 27.5 37.5 R 7 5.60 14.5 41 4800 74 26 36 18 R14 5.59 13.6 40 4500 68 23 34 2.5

C 1 5.65 15.1 48 5400 85.5 26.5 32 1.0 C 9 5.55 15.8. 46 6000 84.5 28,5 34.5 1.0 B 2 6.03 15.3 45 6300 75 25 34 1.5

10 B14 5.58 14.3 43 6300 77 25 33 2.5 328 5.31 15.3 42.5 5700 80 28.5 36.5 1.1 R 7 5.14 13.7 40 6000 81 27 35 1.5 R14 5.01 13.4 39 5600 79 27 35 2.0

C 1 48.5 6300 C 9 5.42 46 6600 5 2 5.65 15.4 47 6300 84.5 27 33

11 B14 5.52 15.1 45 7300 82 28 35 B28 5.40 15.8 45 6200 85 29 35 R 7 5.05 14.1 43 6500 86 27 33 R14 5.09 14.7 43.5 5200 87 29 34

C 1 44 5100 C 9 4.50 14.1 42 6300 93 31 34 B 2 5.60 14.5 43 6500 77.5 25.5 33.9 312B4 5.40 14.8 43 8400 80.5 27 34.5 B28 5.09 14.7 42 •5600 83 29 35 R 7 4.40 12.8 38 e-6600 87 28.5 34 R14 4.72 13.7 40 6400 85.5 28.5 34.5

FLUID !tALANCE (ml /24hrs)

1000

* I I

5100

SODIUMAEXCRETION (m~eq/24 bro)200 I

-I00

150

too

T - n-20

ALDOSTERONE EXCRETION q /24 s)20

16 Sedrst Day

12K

842 i.qt62 19 42 30 39 47 0 7 14 7 14 21 28 7 14 Ambulantl Btdresl jAmbulant

Control Recomey

DAY OF STUDY

Figaure 1. Alterations in fluid balance, sodium and aldosterone excretion.

ISO

PLASMA VOLUME L Ii

52 1

28.1

RED CELL MASS (L.)'

2.0 ,

1.8 LG" n1

Corrcctod for phobotornies 15

EXTRACELLULAR FLUID VOLUME (L)

'5 5

n=13

40- n=16

72- WEIGHT (Kg.)S i

70 -J 68

n ] I n=17

01 7 1q 7 K4 Z1 26 7 14

Ab:ontI BadreM Ambulant Control j Recovery

DAY OF STUDY

Figure 2. Alterations in body fluid compartments and weight.

decei'iber 1970 ii - nasa · decei'iber 1970. part ii . ... 4. blood pressure response to...

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