deep delivery for synergistic tumor ablation · a department of biochemistry and molecular biology,...
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Two-stage Activated Nano-truck Enhanced Specific Aggregation and
Deep Delivery for Synergistic Tumor Ablation
Ziliang Zheng 1 a, Qi Chen 1 a, Shuo Rong 1 a, Rong Dai c, Zhuo Jia c, Xiaoyang Peng a, and Ruiping Zhang *b
a Department of biochemistry and molecular biology, Shanxi Medical University, Taiyuan 030001, China.
b The Affiliated Da Yi Hospital of Shanxi Medical University, Taiyuan 030032, China
c College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
* Corresponding authors. [email protected] (R. Zhang).
1 These authors contributed equally to this work.
Electronic Supplementary Material (ESI) for Nanoscale.This journal is © The Royal Society of Chemistry 2020
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Supporting Figures
Figure S1. A) O 1s XPS spectra and B) C 1s XPS spectra of BMP NTs.
10 20 30 40 50 60
Inte
nsity
(a.u
.)
2 (°)
BMP
JCPDS 71-0071 JCPDS 75-1306
Figure S2. XRD pattern of the BMP NTs.
Figure S3. A) Digital photos, B) UV-vis absorption spectra and C) hydrodynamic sizes of BMP
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NTs (400 μg mL-1) in water, PBS, saline and DMEM medium after 24 h.
0 50 100 150 200 250 300
0
20
40
60
80 0.5 W cm-1
0.75 W cm-1
1 W cm-1
1.25 W cm-1
Figure S4. Temperature elevation of the aqueous dispersion with the same concentration of BMP
NTs (400 μg mL-1) at different laser power densities.
0.0 0.5 1.0 1.5 2.0
0
100
200
300
400
= 43.91%
s = 200.59
-Ln()
Tim
e (s
)
R2 = 0.995
Figure S5. Linear time data versus -ln(θ) obtained from the cooling period of the laser off. (808 nm,
1 W cm-2)
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Figure S6. Hemolysis test of red blood cells treated with the BMP NTs at various concentrations for
4 h. Water and PBS as positive and negative control, respectively.
Figure S7. In vivo T1-weighted MRI images of kidneys on mice before and after i.v. injection with
BMP or BM.
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Figure S8. H&E-stained images of major organs collected from mices at the end of treatment; bars
represent 100 µm.