dementia, parkinson’s disease & dementia with lewy bodies
TRANSCRIPT
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Dementia, Parkinson’s disease & dementia with Lewy bodies
K NicholsonPhD candidate
The University of Melbourne
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Research question
What is the experience of caring for a person with dementia with Lewy bodies (DLB)?
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MethodologyHeuristic inquiry (Moustakas, 1990). 13 spousal carers of people with a diagnosis of DLB.
12 female and 1 male carer.Age 71 (SD±7.6) Years married 48 (SD±7.4) 6 were recruited through dementia networks, 6 through Parkinson’s networks and 1 was a snowball through a carer support group.
Methods: questionnaire on the phone – demographics, assessment process and early signs they noticed in their spouses, in depth interview (12 face to face, 1 telephone)focus group (N=7).
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Definitions Dementia is the term used to describe the symptoms of a large group of illnesses, which cause a progressive decline in a person’s mental functioning. It is a broad term, which describes a loss of memory, intellect, rationality, social skills and normal emotional reactions.
Key words in the WHO 1992 definition. Consciousness is not clouded. ….the primary requirement for diagnosis is evidence of a decline in both memory and thinking
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Definitions
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV TR) states dementia is manifested by both
(1) memory impairmentand (2) one (or more) of the following cognitive disturbances ……………..
PD is a progressive, degenerative neurological condition. It primarily involves a disturbance in the co-ordination of movement and has three main symptoms: tremor, rigidity and bradykinesia (slowness of movement). (Parkinson's Victoria, 2007)
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Perceptions
Prominent feature of dementia is memory lossAnecdotally many people equate dementia, memory loss and AD as one entity. PD is a motor disorder
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The what and where of DLB
It is a progressive, neurodegenerative disease of ageing and thought to be the 2nd most prevalent form of dementia.Guidelines first reported in Neurology in 1996 and refined through 2 further consensus meetings.
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Dementia with Lewy bodiesRepresentation of DLB Consortium Criteria McKeith et al: 2005
Core featureDementia
1 or 2 ofFluctuations Parkinsonism Visual hallucinations
Suggestive features
REM sleep behaviour Severe neuroleptic Neuro-imagingdisorder sensitivity changes
Supportive features
Repeated Transient Severe Systemized Hallucinations Other Depressionfalls & faints syncope autonomic delusions in other medical
dysfunction modalities tests
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Dementia with Lewy bodiesRepresentation of DLB Consortium Criteria McKeith et al: 2005
Core featureDementia
Fluctuations Parkinsonism Visual hallucinations
Suggestive features
REM sleep behaviour Severe neuroleptic Neuro-imagingdisorder sensitivity changes
Supportive features
Repeated Transient Severe Systemized Hallucinations Other Depressionfalls & faints syncope autonomic delusions in other medical
dysfunction modalities tests
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Dementia with Lewy bodies
Dementia defined as progressive cognitive decline of sufficient magnitude to interfere with normal social or occupational function (McKeith, et al 2005). Memory impairment not an early featureDeficits on tests of attention, fronto-subcortical and visuospatial ability
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Dementia
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Memory
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Skill learning and habits
This sub cortical memory involves areas of the cerebellum, the cholinergic basal nucleus of Meynert and the basal ganglia (Gabrieli, 1998; Nolte, 2001) re-entrant circuits between the cortex and the basal ganglia;
the reward-guided choice behaviour circuit the executive circuit for planning and working memorythe motor circuit
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Carers reports of spouses’subcortical deficits
Memory deficits Expressed as retrieval deficits with preservation of recognition
Executive dysfunctionConcepts, problem solving and set shiftingInternally cued behaviourTasks that require planning and sequencing
Attentional impairmentReaction times and vigilanceFluctuations
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DLB – where does it fit?
AD / DLB
DLB / PD
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Dementia with Lewy bodiesRepresentation of DLB Consortium Criteria McKeith et al: 2005
Core featureDementia
Fluctuations Parkinsonism Visual hallucinations
Suggestive features
REM sleep behaviour Severe neuroleptic Neuro-imagingdisorder sensitivity changes
Supportive features
Repeated Transient Severe Systemized Hallucinations Other Depressionfalls & faints syncope autonomic delusions in other medical
dysfunction modalities tests
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Lewy bodies
Lewy bodies - alpha synucleindeposits in cell bodies
Can be found throughout the brain but particularly in the brain stem, basal ganglia, substantia nigra & basal cells of Meynert.
Impact dopaminergic & cholinergic systems
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History
1817 James Parkinson’s essay on Shaking Palsy
1862 Charcot coined the term Parkinson’s disease added cognitive impairment
1912 Fritz Heinrich Lewy (1885–1950 (Frederic Henry Lewey) described and named Lewy bodies
1992 α-synuclein immunocyto-chemistry led to theability to stain Lewy bodies
1995 “Dementia with Lewy Bodies”1st CDLB (McKeith et al)
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DLB/PDD Working GroupNeurology 2007, 68
Lewy body disordersDementia with Lewy bodies DLBParkinson’s disease PDParkinson’s disease dementia PDDLewy body dementias DLB & PDDLewy body disease PD, PDD & DLB
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A way to increase DLB awareness
Neuro degenerative diseasesDementia
ADFTLDVascularOthers including
Alcohol relatedParkinson’s DLB
Parkinson’s disease
Neuro degenerative diseases
Amyloidopathy: AD
Tauopathies: AD / FTLD
Alphasynucleinopathies:DLBPDPDD
Other NDDs:
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I would like to acknowledge:My supervisors at the University of Melbourne:Dr P St Leger & Prof D Ames for their continuing support
The carers who gave of their time & openly shared their experiences with me.
Scholarship support from Alzheimers_Logo_PMS_Sm
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ReferencesAPA. (2000). The Diagnostic and Statistical Manual of Mental Disorders (DSM), published by the American Psychiatric Association, (4 ed.). Arlington: APPI.Gabrieli, J. D. E. (1998). Cognitive Neuroscience of Human Memory. Annual Review of Psychology, 49, 87-115.Lippa, C. F. M., Duda, J. E. M., Grossman, M. M., Hurtig, H. I. M., Aarsland, D. M., Boeve, B. F. M., et al. (2007). DLB and PDD boundary issues: Diagnosis, treatment, molecular pathology, and biomarkers. Neurology, 68(11), 812-819. McKeith, I. G., Galasko, D., Kosaka, K., Perry, E., Dickson, D. W., Hansen, L. A., et al. (2005). Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium. Neurology, 65(12), 1992.
Moustakas, C. (1990). Heuristic Research: Design, Methodology, Applications. Newbury Park CA: Sage Publications Inc.Nolte, J. (2001). The Human Brain: An Introduction to Its Functional Anatomy (5 ed.). St Louis: Mosby.Parkinson's Victoria. (2007). So... I've got Parkinson's...what's that? . Melbourne: PA.World Health Organisation. (1992). The ICD-10 Classification of Mental and Behavioural Disorders. Clinical Descriptions and Diagnostic Guidelines. Geneva: WHO.