dennis hall organic and medicinal
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Dennis Hall Organic and Medicinal Web site: http://www.chem.ualberta.ca/~dhall/ Email: [email protected] Phone: 780-492-3141
Research keywords: Organic synthesis, organoboron chemistry, boronic acids, green chemistry, catalysis, transition metals, stereocontrol, medicinal chemistry, chemical biology. R&D capabilities: Synthesis of organic compounds, compound characterization, boronic acids. Techniques and instrumentation: NMR, HPLC-MS, chiral HPLC, microwave chemistry. Examples of industrial collaborations and commercialization: • Lead compound for cancer chemotherapy The imidopiperidine A12B4C3 was developed as a promising inhibitor of the DNA repair enzyme polynucleotide kinase-phosphatase, in collaboration with Prof. Michael Weinfeld (UofA Oncology) and the Centre for Drug Research and Development (Vancouver), funded by Alberta Cancer Fund, CIHR, Pfizer-CDRD Innovation Fund. This compound could lead to a more effective treatment of tumors resistant to radiotherapy. • Catalyst for direct amide formation The MIBA catalyst, a boronic acid, was developed with GreenCentre Canada and licensed to Sigma-Aldrich. This catalyst facilitates the synthesis of biologically relevant amides and drastically reduces the amount of waste produced. Licensing opportunities: representative patents and invention reports: 1) Patent title: Method for the Organocatalytic Activation of Carboxylic Acids for Chemical
Reactions Using Ortho-Substituted Arylboronic Acids, US patent US 8,822,720 B2, granted on Sept. 2, 2014; International PCT application CA2008/001554, filed on Jan. 21, 2010.
Potential applications: Amide formation for pharmaceuticals, agrochemicals, etc. 2) Patent title: Small Molecule Inhibitors of Polynucleotide Kinase/Phosphatase and Uses
Thereof. US provisional patent #61/184,013 (filed June 4, 2010), #61/263,711 (filed Nov. 23 2009), Int. PCT/CA2010/000846 (June 4, 2010).
Potential applications: Cancer chemotherapy and radiotherapy.
B(OH)2
I
MeO
MIBA catalyst for direct amidation
Sigma-Aldrich Catalog # 746177