department of chemistry research highlights ... a t i o n a l u n i v e r s i t y o f s i n g a p o...
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DEPARTMENT OF CHEMISTRY
N a t i o n a l U n i v e r s i t y o f S i n g a p o r e
Research Highlights & Synopses 2005
Associate Professor Ang Siau Gek
Assistant Professor Ryan PA Bettens
Professor Chan Sze On Hardy
Assistant Professor Chin Wee Shong
Associate Professor Chuah Gaik Khuan
Assistant Professor Fan Wai Yip
Senior Research Fellow Dr Goh Lai Yoong
Professor Goh Suat Hong
Associate Professor Leslie J Harrison
Professor Hor Tzi Sum Andy (Head)
Research Fellow Dr Huynh Han Vinh
Assistant Professor Huang Dejian
Associate Professor Stephan Jaenicke
Associate Professor Kang Hway Chuan
Associate Professor Stephan Kasapis
Associate Professor Khoo Soo Beng
Associate Professor Khor Eugene
Associate Professor Lai Yee Hing
Assistant Professor Lam Yulin
Assistant Professor Martin J Lear
Lecturer Dr Adrian M Lee
Professor Lee Hian Kee (Dty Head)
Lecturer Dr Leong Lai Peng
Associate Professor Leong Weng Kee
Professor Li Fong Yau Sam
Associate Professor Li Tianhu
Associate Professor Loh Kian Ping (Asst Head)
Assistant Professor Lu Yixin
Lecturer Dr Mak Ka Wai Karen
Lecturer Dr Ng Kai Ling
Assistant Professor David G Popovich
Assistant Professor Sim Wee Sun
Associate Professorial Fellow Siow Kok Siong
Assistant Professor Tan Choon Hong
Assistant Professor Toh Chee Seng
Assistant Professor Valiyaveettil Suresh
Lecturer Dr Szeto Ka Fai Alan
Associate Professor Jagadese J Vittal
Research Fellow Dr Weng Zhiqiang
Assistant Professor Thorsten Wohland
Associate Professor Wong Ming Wah Richard (Dty Head)
Professor Xu Guo Qin
Assistant Professor Xu Qinghua
Assistant Professor Xue Feng
Assistant Professor Yao Shao Qin
Assistant Professor Yip Hon Kay John
Associate Professor Zhou Weibiao
MainMainFacultyFaculty
Emeritus Professor Ang How Ghee
Emeritus Professor Huang Hsing Hua
Emeritus Professor Kiang Ai Kim
Adjunct Associate Professor Anthony D Buss
Adjunct Assistant Professor Chan Ping Kwong
Adjunct Assistant Professor Thomas Keller
Adjunct Assistant Professor Kong Siu Wai Eric
Adjunct Associate Professor Joseph I Rasiah
Visiting Professor Robert Huber
Visiting Associate Professor Perera C Oswald
Visiting Professor Bahruddin bin Saad
EmeritusEmeritusFacultyFaculty
AdjunctAdjunctFacultyFaculty
VisitingVisitingFacultyFaculty
Research FocusResearch Focus• Organic/Organometallic Chemistry• Osmium and ruthenium cluster compounds containing Group
15 ligands
Recent HighlightsRecent HighlightsSynopsisMy research work is concerned with the application of spectroscopic techniques and X-ray diffraction methods to study the structures of a variety of molecules. Another area of focus is on the synthesis and chemistry of ligands containing nitrogen, phosphorus and arsenic.
Representative PublicationsRepresentative PublicationsH.G. Ang, S.G. Ang, Shaowu Du, J. Organomet. Chem., 589, 133-137 (1999).H.G. Ang, S.G. Ang, S. Du, J. Organomet. Chem., 590, 1-6 (1999).D.S.H. Tan, S.G. Ang, T.S. Sim, Biochem. Mol. Biol. Int., 44, 333-345 (1998). S. G. Ang, P. S. Chong. , Talanta, 45, 693-701 (1998). H.K. Yap, X.J. Zuo, M. Toyoda, Y. Okada, S.G. Ang, Y.H. Lai, A. Matloff, A. Marchevsky, V.S. Ramgolam, S.C. Jordan, Transplant Proc, 30, 970-981 (1998).
Ph.D., Cambridge University, 1987
M.Sc., National University of Singapore, 1984
B.Sc., National University of Singapore, 1981
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/angsg.htm
AngS
iauGe
k
1
Research FocusResearch Focus• Computational chemistry• Experimental and theoretical high resolution spectroscopy
Recent HighlightsRecent HighlightsReferenceR.P.A. Bettens, J. Phys. Chem A., 108, 1826 (2004).
SynopsisIt is known that by adding together energies that can be rapidly and cheaply calculated one is able to obtain very accurate relative total energies of molecules. However, this result is for more general and far-reaching than simply obtaining total energies. Other molecular properties can also be accurately reproduced as we show in publication 4 above and the upcoming 2006 publication.
Representative PublicationsRepresentative PublicationsR.P.A. Bettens , M.A. Collins., J. Chem. Phys., 116, 101, (2002).I. Medvedev, M. Winnewisser, F.C.De Lucia, E. Herbst, E. Yi, L.P. Leong, R.P.A. Bettens, E. Biankowska-Jaworska, O. Desyatnyk, L. Pszczo´nkowski, Z. Kisiel, Ap. J. (Supp), 148, 593, (2003).R.P.A. Bettens, J. Am. Chem. Soc, 125, 584, (2003).R.P.A. Bettens, J. Phys. Chem A., 108, 1826 (2004).E. Ye, R.P.A. Bettens, F.C.De Lucia, D.T. Petkie, S. Albert, J. Mol. Spectrosc., 232, 61, (2005).
Postdoc., Australian National University, 1999
Postdoc., Ohio State University, 1996
Postdoc., ETH, Zurich, 1994
Ph.D., Monash University, 1992
B.Sc., The University of Queensland, 1986
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/bettens.htm
MAJOR RECOGNITIONTeaching Excellence Award, National University of Singapore, 2002
Ryan PA Bettens
2
Research FocusResearch Focus• Functional polymers• Nanomaterials
Recent HighlightsRecent HighlightsReferenceH.B. Xia, D.M. Cheng, H.S.O. Chan, Journal of Materials Chemistry, 15, 4161-4166 (2005).
SynopsisY-junction polyaniline (PANI) nanorods and nanotubes (40-100 nm in diameter and a few micrometers in length) were prepared, for the first time, using self-assembled magnetic nanoparticles as templates and pH control in an aqueous medium. The morphologies of PANI nanostructures (rods and tubes) were confirmed by TEM and the effect of reaction conditions on the morphologies of PANI nanostructures was also studied.
Representative PublicationsRepresentative PublicationsHo. P.K.H, Tan. B.G.T, Tan KL, Ng. S.C, Chan H.S.O, Journal of the American Chemical Society, 117, 8517-8523 (1995).Chan. H.S.O, Ng. S.C, Progress in Polymer Science, 23, 1167-1231 (1998).Ng. S.C, Lu. H.F, Chan. H.S.O, Advanced Materials, 12, 1311-1315 (2000).Cheng. D.M, Xia. H.B, Chan. H.S.O, Journal of Nanoscience and Nanotechnology, 5, 466-472 (2005).Xia. H.B, Xiao.C., Chan.H.S.O, Nanotechnology, 15, 1807-1811 (2004).
Ph.D., University of Manchester Institute of Science & Technology, 1975
B.Sc., Southbank Polytechnic, 1972
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/chanhardy.htm
3
Chan
Sze
On H
ardy
Research FocusResearch Focus• Nanostructural materials and their assembly • Surface and spectroscopy
Recent HighlightsRecent HighlightsReferenceW.P. Lim, Z.H. Zhang, H.Y. Low, W.S. Chin, Angew. Chem. Int. Edn, 43, 5685, (2004).
SynopsisAn unprecedented preparation of Ag2S nanocrystals, with predictable sizes and shapes, using chemical method starting from an easily prepared silver precursor is reported. Through a careful tuning of several critical thermodynamic and kinetic parameters, well-defined shapes of Ag2S nanocrystals, from nanocubes, faceted or spherical nanocrystals, to nanorods, can be readily produced.
Representative PublicationsRepresentative PublicationsW.P. Lim, Z.H. Zhang, H.Y. Low, W. S. Chin, Angew. Chem. Int. Edn, 43, 5685, (2004).W.P. Lim, H.Y. Low, W.S. Chin, J. Phys. Chem. B, 108, 13093, (2004).T.P. Ang, T.S.A. Wee, W.S. Chin, J. Phys. Chem. B, 108, 11001, (2004).Z.H. Zhang, W.S. Chin, J.J. Vittal, J. Phys. Chem. B, 108, 18569, (2004).T.P. Ang, W.S. Chin, J. Phys. Chem. B, 109, 22228, (2005).
Postdoc., University of Bristol, 1994
Ph.D., National University of Singapore, 1993
B.Sc., National University of Singapore, 1987
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/chinws.htm
Chin Wee Shong
8 1 2 1 6 2 0
0
1 0
2 0
3 0
4 0
5 0
6 0
1 2 0 o C 1 0 0 o C 8 0 o C
Part
icle
Siz
e (n
m)
[H D A ] : [P r e c u r s o r ] R a t io
4
Chua
hGaik
Khu
anResearch FocusResearch Focus• Development of catalytic materials • Heterogeneous catalysis in fine chemicals
Recent HighlightsRecent HighlightsReferenceY.T. Nie, G.K. Chuah, S. Jaenicke, Chem. Commun., in press.
SynopsisThe one-pot conversion of citronellal to menthol can be selectively catalysed by either a bifunctional Ni/Zr-zeolite beta catalyst or a dual catalyst system of Zr-beta and Ni/MCM-41, giving a high diastereoselectivity to (±)-menthol of 90 – 94 %.
Representative PublicationsRepresentative PublicationsY.Z. Zhu, G.K. Chuah, S. Jaenicke, Journal of Catalysis, 227, 1- 10, (2004).D.B. Ravindra, Y.T. Nie, S. Jaenicke, G.K. Chuah , Catalysis Today, 96, 147 – 153, (2004).Y.Z. Zhu, Y.T. Nie, S. Jaenicke, G.K. Chuah, Journal of Catalysis, 229, 404 – 413, (2005).G.K. Chuah, S. Jaenicke, Y.Z. Zhu, S.H. Liu, Current Organic Chemistry, in press.Y.T. Nie, G.K. Chuah, S. Jaenicke, Chem. Commun., in press.
Postdoc., Fritz-Haber-Instituet, Berlin , 1987
Ph.D., Texas A&M University, 1987
B.Sc., University of Singapore, 1984
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/chuahgk.htm
C=O OH
Ni/Zr-beta orZr-beta-Ni/MCM-41
OHcyclisation hydrogenation
One-pot domino reaction
5
Research FocusResearch Focus• Photochemistry and infrared spectroscopy• Organometallics and nanomaterials
Recent HighlightsRecent HighlightsReferenceE. Ye, H. Tan, S. Li, W.Y. Fan, Angewandte Chemie, in press.
SynopsisProduction of uniform core-shell palladium spherical aggregates by 532 nm laser photodecomposition of Pd(PPh3)4 to form the metal core followed by self-aggregation around the core by smaller Pd nanocrystals (<5nm) and free phosphines produced from thermal decomposition of the remaining precursor.
Representative PublicationsRepresentative PublicationsH. Tan, E. Ye, W.Y. Fan,, Advanced Materials, in press.E. Ye, H. Tan, S. Li, W.Y. Fan, Angewandte Chemie, in press.S. Li, T.S. Chwee, W.Y. Fan,, J. Phys.l Chem A, in press. T.S. Chong, P. Li, W.K. Leong, W.Y. Fan, J. Organomet. Chem, 690, 4132, (2005).H. Tan, L. Wong, G..Kiruba, W.K. Leong, M.W.R. Wong, W.Y. Fan, J. of Phys. Chem. B, 109, 19657, (2005).
Postdoc., University of California Berkeley, 2000
Ph.D., University of Cambridge, 1998
M.Sc., University of Toronto, 1996
B.Sc., University of London, 1994
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/fanwy.htm
Fan WaiYip
6
Research FocusResearch Focus• Organochromium Chemistry
Recent HighlightsRecent HighlightsReferenceS.L. Kuan, W.K. Leong, L.Y. Goh, R.W. Webster, Organometallic., 24, 4639-4648, (2005).
Synopsis[Cp*RuIII{HB(mt)3}]+ (1A) and [Cp*RuII{HB(mt)3}] (2A) were synthesized by the reactions of K[HB(mt)3] with [Cp*RuIIICl2]2 and [Cp*RuII(OMe)]2, respectively. 1A and 2A exist in the solid state in κ 3-S,S',S'' coordination. However, both compounds undergo an isomerization reaction in solution, resulting in κ 3-H,S,S' coordination about the Ru, giving 1B and 2B, respectively). The rate and equilibrium constants associated with the reactions illustrated have been determined over a range of temperatures.
Representative PublicationsRepresentative PublicationsL.Y. Goh, W. Chen, R.C.S. Wong, Angew Chem., Int. Ed. Engl. , 32, 1728-1729, (1993).L.Y. Goh, Z. Weng, W.K. Leong, P.H. Leung, Angew. Chem. Int. Ed., 40, 3236-3239, (2001).L.Y. Goh, Z. Weng, W.K. Leong, J.J. Vittal, J. Am. Chem. Soc., 124, 8804-8805, (2002).Z. Weng, L.Y. Goh, Acc. Chem. Res. , 37, 187-199, (2004).R.Y.C. Shin, M.E. Teo, W.K. Leong, J.J. Vittal, J.H.K. Yip, L.Y. Goh, R.W. Webster, Organometallic., 24, 1483-1494, (2005).
D.Sc., University of London, 1997
Ph.D., University of London, 1967
B.Sc., University of HongKong, 1963
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/gohly.htm
MAJOR RECOGNITIONRoyal Society Commonwealth Developing Countries Fellow-ship, Royal Society, UK, 1991
Gold Medal by Institute of Chemistry, Malaysia, 2001
Gold Medal by Rotary Club Malaysia Research Foundation, 2003
GohL
ai Yo
ong
7
Research FocusResearch Focus• Polymer/carbon nanotube nanocomposites• Double-C60-end-capped polymeric materials
Recent HighlightsRecent HighlightsReferenceM. Wang, K. P. Pramoda and S. H. Goh. Chem. Mater., 16, 3452, (2004).
SynopsisThe aggregation of C60 moieties in double-C60-end-capped poly(ethylene oxide) (FPEOF) leads to a network-like structure. The storage moduli at 40°C of pseudo-semi-interpenetrating networks based on FPEOF and poly(methyl methacrylate) (PMMA) (x,Δ,○) are 10-16 times that of PMMA (●).
Representative PublicationsRepresentative PublicationsM. Wang, K.P. Pramoda, S.H. Goh, Polymer, 46, 11510, (2005).Y. Liu, D.C. Wu, W.D. Zhang, X. Jiang, C.B. He, T.S. Chung, S.H. Goh, K.W. Leong, Angew. Chem. Int. Ed. 44, 4782, (2005).M. Wang, K.P. Pramoda, S.H. Goh, Chem. Mater., 16, 3452, (2004).H.W. Goh, S.H. Goh, G.Q. Xu, K.Y. Lee, G.Y. Yang, Y.W. Lee, W.D. Zhang, J. Phys. Chem. B, 107, 6056, (2003).T. Song, S. Dai, K.C. Tam, S.Y. Lee, S.H. Goh, Langmuir, 19, 4798, (2003).
D.Sc., National University of Singapore, 1993
Ph.D., University of Akron, 1971
M.Sc., University of Akron, 1966
B.Sc., National University of Singapore, 1964
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/gohsh.htm
MAJOR RECOGNITIONNational Science Award, National Science and Technology Board, Singapore, 1997
Achievement Award, ASEAN Committee of Science and Technology, 1998
FACS Citation Award, Federation of Asian Chemical Societies, 2003
GohSuatHong
4 0 8 0 1 2 00
1 0
2 0
3 0
4 0
Sto
rage
mod
ulus
(GPa
)
T e m p e ra tu re (°C )
8
Leslie
J H
arris
onResearch FocusResearch Focus• Organic chemistry • Natural products
Recent HighlightsRecent HighlightsSynopsisWe are interested in the isolation of natural products and determination of their structures using mainly 1D and 2D nuclearmagnetic resonance techniques. At present, we are concentrating on the constituents of three plant families, the Guttiferae, the Hepaticaeand the Orchidaceae. The compounds obtained are subjected to biological testing.
Representative PublicationsRepresentative PublicationsL.H.D. Nguyen, L.J. Harrison, Phytochemistry, 53, 111-114 (2000). L.H.D. Nguyen, L.J. Harrison, Phytochemistry, 53, 111-114 (1999). R. Huang, L.J. Harrison, K.Y. Sim, Tetrahedron Lett., 40, 1607-1610 (1999). Y.W. Leong, L.J. Harrison, A.D. Powell, Phytochemistry, 50, 1237-1241 (1999). Y.W. Leong, L.J. Harrison, Phytochemistry, 50, 849-857 (1999).
Ph.D., University of Glasgow, 1983
B.Sc., University of Glasgow, 1980
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/harrison.htm
9
Research FocusResearch Focus• Organometallic syntheses & homogeneous catalysis• Heterometallic & nanomaterials assembly
Recent HighlightsRecent HighlightsReference(2005), submitted for publication.
SynopsisA catalytically active bimetallic complex [η-C5H4CH=N(C6F5)]Fe[η-C5H4PPh2]Ni(AlMe3) that models an active intermediate in demonstrating the “Ziegler Nickel Effect” has been isolated and crystallographicallyestablished. This unusual structure reveals a short Ni···Al contact (2.509(2) Å) supported by an unexpected electron-poor iminebridge, together with a bridging methyl with an agostic α-hydride.
Representative PublicationsRepresentative PublicationsZ. Weng, S. Teo, L.L. Koh, T.S.A. Hor, Angew. Chem. Int. Ed., 44, 7560-7564, (2005).Z. Weng, S. Teo, L.L. Koh, T.S.A. Hor, Organometallics, 23, 3603-3609, (2004).Z. Li, W. Zheng, H. Liu, K.F. Mok, T.S.A. Hor, Inorg. Chem., 42, 8481-8488, (2003)S.W.A. Fong, J.J. Vittal, W. Henderson, T.S.A. Hor, Chem. Commun., 421-422, (2001).H. Liu, A.L.C. Tan, K.F. Mok, T.C.W. Mak, T.S.A. Hor, A.S. Batsanov, J.A.K. Howard, J. Am. Chem. Soc., 119, 11006-11011, (1997).
Postdoc., Yale University , 1984
D.Phil., University of Oxford, 1983
B.Sc.(Hons), Imperial College of Science and Technology, 1979
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/hor.htm
MAJOR RECOGNITIONWilsmour Fellow, University of Melbourne, Australia, 2004
Anthony Mason Fellow, University of New South Wales, Australia, 1999
Humboldt Fellow, Alexander von Humboldt Foundation,Germany, 1989 & 2003
ASEAN Achievement Award (Sciences), ASEAN Business Forum, Malaysia, 1994
NSTB Young Scientist & Engineer Award, National Science & Technology Board, Singapore, 1991
HorTziSum Andy
10
Huy
nh H
an V
inhResearch FocusResearch Focus• Organometallic chemistry • Catalysis
Recent HighlightsRecent HighlightsReferenceH.V. Huynh, C. Holtgrewe, T. Pape, L.L. Koh, E. Hahn, Organometallics, (2005), ASAP online article.
SynopsisA novel general method for the synthesis of nickel(II) carbenecomplexes by reacting Ni(OAc)2 with azolium salts in molten [Bu4N]X (X = Br, I or BF4) as ionic liquids has been developed. Using this method, the first nickel(II) benzimidazolin-2-ylidene complexes 8 – 12 of the type trans-[NiX2(NHC)2] have been prepared and their solid state structures determined by X-ray diffraction studies.
Representative PublicationsRepresentative PublicationsH.V. Huynh, C. Holtgrewe, T. Pape, L.L. Koh, E. Hahn, Organometallics, (2005), ASAP online article.S.K. Quek, I. Lyapkalo, H.V. Huynh, , Tetrahedron, (2005), accepted.H.V. Huynh, J.H.H. Ho, T.C. Neo, L.L. Koh , J. Organomet. Chem, 690, 3854-3860, (2005).H.V. Huynh, D. LeVan, F.E. Hahn, T.S.A. Hor , J. Organomet. Chem, 689, 1766-1770, (2004).
Ph.D., University Münster(WWU), Germany, 2002
B.Sc., University Münster (WWU), Germany, 1999
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/huynh.htm
MAJOR RECOGNITIONHumboldt Research Fellow, Alexander von Humboldt Foundation, 2003-2004
8: R = R' = CH3, X = I 9: R = R' = C3H5, X = Br10: R = R' = C3H7, X = Br11: R = CH3, R´ = C3H5, X = Br 12: R = C3H7, R´ = CH3, X = I
N
N
R
R'
H
X
+ Ni(OAc)2N
N
R
R'
N
N
R
R'
NiX
XIonic liquid
120 °C- 2 HOAc
11
Research FocusResearch Focus• Antioxidation / oxidation and yin / yang balance in traditional
Chinese medicine • Transition metal chemistry and catalysis
Recent HighlightsRecent HighlightsReferenceB. Ou, D.J. Huang, M. Hampsch-Woodill, J.A. Flanagan, FASEB J., 17(2), 127-129, (2003).
SynopsisWe attempted to define the physical meaning of yin-yang in TCM by correlating it with biochemical processes. We propose that yin-yang balance is antioxidation-oxidation imbalance with yin representing antioxidationand yang as oxidation. Our hypothesis opens an avenue to systematically study the yin-yang balance and its health implications with the use of modern biochemical tools.
Representative PublicationsRepresentative PublicationsD.J. Huang, B. Ou, L. Ronald, J. Agri. Food Chem, 53 , 1841-1856, (2005).B. Ou, D.J. Huang, M. Hampsch-Woodill, J.A. Flanagan, FASEB J., 17(2), 127-129, (2003).D.J. Huang DJ, P.R. Koren, K. Folting, E.R. Davidson, K.G. Caulton, J. Am. Chem. Soc.; 122(37), 8916-8931, (2000).D.J. Huang, B. Ou, M. Hampsch-Woodill, J. Flanagan, J. Agric. Food Chem, 50(16); 4437-4444, (2002).D.J. Huang, W.E. Streib, J.C. Bollinger, K.G. Caulton, R.F. Winter, T. Scheiring, J. Am. Chem. Soc.,121(35), 8087-8097, (1999).
Postdoc., Massachusetts Institute of Technology, 2001
Ph.D., Indiana University Bloomington, 1999
M.Sc., Chinese Academy of Sciences, 1990
B.Sc., Fujian Teachers University, 1987
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/huangdj.htm
Huang Dejian
12
Step
han J
aenick
eResearch FocusResearch Focus• Heterogeneous catalysis, enzyme catalysis, homogeneous
catalysis • Microporous materials, zeolites, mesoporous materials
Recent HighlightsRecent HighlightsReferenceE.-L. Teo, G.-K. Chuah, A.R.J. Huguet, S. Jaenicke, G. Pande, Y. Zhu, Catalysis Today, 97, 263-270, (2004).
SynopsisDynamic kinetic resolution of racemic 1-phenylethanol has been achieved in a single non-aqueous phase by combining enzymatic transesterification with racemization of the off-enantiomer over a hydrophobic zeolite beta catalyst. In another approach, a fluorous trans-alkylation reagent 1 was synthesized which was enzymatically transferred to one enantiomer of the chiralalcohol 2, rendering the derivative soluble in a fluorous phase and allowing for its easy separation in anorqanic-fluorous biphasic system.
Representative PublicationsRepresentative PublicationsS. Jaenicke, Catalysis Surveys from Asia, 9, 173-185, (2005).E.-L. Teo, G.-K. Chuah, A.R.J. Huguet, S. Jaenicke, G. Pande, Y. Zhu, Catalysis Today, 97,263-270, (2004). Y. Zhu, S. Jaenicke, G.K. Chuah, Journal of Catalysis, 218, 396 – 404, (2003).G.K. Chuah, X. Hu, P. Zhan, S. Jaenicke, J. Molecular Catalysis A: Chemical, 181, 25-31, (2002).X. Hu, F.L. Foo, G.K. Chuah, S. Jaenicke, J. Catalysis, 195, 412, (2000).
Postdoc., Max Planck Society, 1988
Postdoc., Michigan State University, 1983
Ph.D., Dr. rer. nat., 1981
B.Sc., Diplomchemiker, 1976
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/jaenicke.htm
OH O OH
O
CF3(CF2)7CH2CH2COOCH2CF3
(CF2)7CF3
(R)-3 (S)-21rac-2 workup:1. filter off the enzy2. distill off the solv3. dissolve the resid in MeOH4. extract with mem
CAL-B45 oCTBMe ++
13
Research FocusResearch Focus• Computational chemistry
Recent HighlightsRecent HighlightsSynopsisMy research focuses upon the use of simulations grounded in statistical and quantum mechanics to provide molecular scale "pictures" of physical and chemical processes in molecules, clusters, surfaces and bulk materials. We are interested in modelling the kinetics of catalytic reactions, the structure and properties of solid and cluster surfaces, reaction energetics, the interactions and reactions of molecules adsorbed on surfaces, and the energetics of defects on surfaces and in the bulk.
Representative PublicationsRepresentative PublicationsH.C. Kang, Surf. Sci., 445 167-176 (2000).Z.H. Loh, H. C. Kang, J. Chem. Phys., 112 2444-2451 (2000).C. Yang, H.C. Kang, J. Chem. Phys., 110 11029-11037 (1999). C. Yang, H.C. Kang, Surf. Science 409, 521 (1998).H.C. Kang, J. Chem. Phys. 109 6911-6915 (1998).
Ph.D., Caltech , 1989
B.Sc., Yale University , 1983
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/kanghc.htm
Kang H
wayChuan
14
Step
han K
asapis
Research FocusResearch Focus• Biopolymer structure in relation to functionality in solutions and
gels• Functional ingredient– biopolymer matrix interactions
Recent HighlightsRecent HighlightsReferenceS. Kasapis, I.M. Al-Marhoobi, Biomacromolecules, 6, 14-23, (2005).
SynopsisA working hypothesis was formulated and applied to high-solid mixtures of biomaterials thus identifying phase or state transitions in the time/temperature function. This led to the development of a mechanical glass transition temperature as the threshold of two distinct molecular processes governing the “rubber-to-glass”transformation. A stage was reached at which the predictions of the theoretical protocol were found to be in good agreement with theexperimental development of viscoelasticity in the high-solid κ-carrageenan/gelatin mixture ranging from the rubbery plateau and the transition region to the glassy state.
Representative PublicationsRepresentative PublicationsS. Kasapis, I.M. Al-Marhoobi, Biomacromolecules, 6, 14-23, (2005)S. Kasapis, Journal of Agricultural and Food Chemistry, 52, 2262-2268, (2004).S. Kasapis, I.M. Al-Marhoobi, J.R. Mitchell, Biopolymers, 70, 169-185, (2003).S. Kasapis, I.M. Al-Marhoobi, M. Deszczynski, J.R. Mitchell, R. Abeysekera, Biomacromolecules, 4, 1142-1149, (2003).S. Kasapis, J. Desbrières, I.M. Al-Marhoobi, M. Rinaudo, Carbohydrate Research, 337, 595-605, (2002).
Postdoc., Cranfield University, 1993
Ph.D., Cranfield University, 1991
M.Sc., University of London, 1988
B.Sc., Aristotle University, 1986
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/sk.htm
MAJOR RECOGNITIONMedal of the Royal Society of Chemistry Food Group, Royal Society of Chemistry, 1998
15
Research FocusResearch Focus• Electrochemistry and electroanalytical chemistry • Chemically modified electrodes
Recent HighlightsRecent HighlightsReferenceJ. Premkumar, S.B. Khoo, Chemical Communications, 640-642, (2005).
SynopsisSuper-hydrophilicity was first generated purely by electrochemical means (in the absence of uv illumination source) at the surface of a In2O3-SnO2 electrode. This is achieved by the application of high anodic potentials for a prolonged period. Such surfaces are reversibly converted back to their original hydrophobic state on storage (in air or in water).
Representative PublicationsRepresentative PublicationsJ. Premkumar, S.B. Khoo, Chemical Communications, 640-642, (2005).B. Yu, S.B. Khoo, Electrochemistry Communications, 4, 737-742, (2002).S.B. Khoo, F. Chen, Analytical Chemistry, 74, 5734-5741, (2002).M.R. Khan, S.B. Khoo, Analytical Chemistry, 68, 3290-3294, (1996).Q. Cai, S.B. Khoo, Analytical Chemistry, 66, 4543-4550, (1994).
Postdoc., University of Utah, 1984
Ph.D., University of Alberta, 1984
B.Sc. (Hons), Universiti Sains Malaysia, 1978
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/khoosb.htm
KhooSooBeng
16
Kho
rEug
ene
Research FocusResearch Focus• Chitin and chitosan for biomedical applications
Recent HighlightsRecent HighlightsReferenceY. Zou, E. Khor, Biomacromolecules, 6, 80-87, 2005.
SynopsisA methodology was developed to produce chitin derivatives under homogeneous conditions. This has widespread implications for producing a myriad of chitin derivatives for various applications.
Representative PublicationsRepresentative PublicationsY. Zou, E. Khor, Biomacromolecules, 6, 80-87, (2005).N.L.M. Yusof, L.Y. Lim, E. Khor, Carbohydrate Research, USA, 339(16), 2701-2711, (2004).E. Khor, N.L.M. Yusof, Medical Device & Diagnostic Industry, USA, 26 (4), 70-75, (2004).E. Khor, L.Y. Lim, Biomaterials, 24 (13), 2339-2349, (2003).Z. Ge, A-S Baguenard, L.Y. Lim, A. Wee, E. Khor, Biomaterials, 25, 1049-1058, (2004).
Ph.D., Virginia Tech, 1983
B.Sc., Lakehead University, 1979
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/khore.htm
MAJOR RECOGNITIONAssociate Editor, Biomaterials, 2005
International Committee, 7th Asia Pacific Chitin ChitosanSymposium, 2006
OO
NHAc
OH
OH n
OO
NHAc
OTs
OH n
ONaEtOOC
OC6H4COOEtO
O
NHAcOH n
OC6H4COOHO
O
NHAcOH n
OO
NHAc
CH(COOEt)2
OH n
OO
NHAc
P(O)(OEt)2
OH n
OO
NHAc
CH(COOH)2
OH n
TsCl
Et3N/DMAc
1) tBuOK/DMSO
2) H+
DMAc
NaCH(COOEt)2
DMAc
tBuOK/DMSO
(EtO)2P(O)Na/DMAc
1 2
3 4
5
67
2) H+1)
17
Research FocusResearch Focus• Organic synthesis
Recent HighlightsRecent HighlightsSynopsisOur research interests are centred mainly on the studies of conjugated aromatic systems going from theoretically interesting molecules to organic materials for specific applications. A separate effort focuses on the investigation of selected Chinese medicinal plants.
Representative PublicationsRepresentative PublicationsY. Cao, K.S. Yong, Z.Q. Wang, W.S. Chin, Y.H. Lai, J.F. Deng, G.Q. Xu, J. Am. Chem. Soc., 122, 1812-1813 (2000).W. Huang, H. Meng, W.-L. Yu, J. Pei, Z.K. Chen, Y.-H. Lai, Macromolecules, 32, 118-126 (1999).Y. Cao, X.M. Wei, W.S. Chin, Y.-H. Lai, J.F. Deng, S.L. Bernasek, G.Q. Xu, J. Phys. Chem. B, 103, 5698-5702 (1999). H.K. Yap, X.J. Zuo, M. Toyoda, Y. Okada, S.G. Ang, Y.-H. Lai, J.M. Matloff, A. Marchevsky, V.S. Ramgolam, S.C. Jordan, Transplant. Proc., 30, 980-981 (1998).
Postdoc., University of California at Berkeley and Lawrence Berkeley Laboratory, 1982
Ph.D., University of Victoria, 1980
B.Sc., Nanyang University , 1978
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/laiyh.htm
18
Lai Yee Hing
Lam
Yulin
Research FocusResearch Focus• Combinatorial chemistry• Medicinal chemistry
Recent HighlightsRecent HighlightsReferenceH. Fu, Y.L. Lam, J Comb Chem, 7, 734-738, (2005).
SynopsisA highly regioselective and traceless solid-phase route to N1,N7-disubstituted purines has been developed. Key steps in the reaction strategy involves (i) Michael addition of 6-chloropurine to the REM resin, (ii) oxidation, (iii) N1-alkylation, (iv) quaternization and (v) product release through Hofmann elimination.
Representative PublicationsRepresentative PublicationsR. He, Y.L Lam, J Comb Chem, 7, 916-920, (2005).H. Fu, Y.L. Lam, J Comb Chem, 7, 734-738, (2005).W. Li, Y.L. Lam, J Comb Chem, 7, 721-725, (2005).W. Li, Y.L. Lam, J Comb Chem, 7, 644-647, (2005).K.H. Kong, Y. Chen, X. Ma, W.K. Chui, Y.L. Lam, J Comb Chem, 6, 928-933, (2004).
Postdoc., Institute of Molecular and Cell Biology, 1997
Postdoc., The Scripps Research Institute, 1997
Ph.D., National University of Singapore, 1992
B.Sc. (Hons), National University of Singapore, 1987
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/lamyl.htm
OHCl
O
O
O
N
N
O
N
N
R1 R2
19
Research FocusResearch Focus• Total synthesis of complex natural products of biological
significance • New methods and strategies in both organic and medicinal
chemistry
Recent HighlightsRecent HighlightsReferenceY. Koyama, M.J. Lear, F. Yoshimura, I. Ohashi, T. Mashimo, M. Hirama,Org. Lett. , 7, 267-270, (2005).
SynopsisAdvanced approaches towards the synthesis of the kedarcidinchromophore have been accomplished through new and efficient gram-scale syntheses. In ongoing work, we show that anionic, cerium-acetylide procedures can forge unstable, nine-membered diyne cores within pre-existing ansamacrolide frameworks.
Representative PublicationsRepresentative PublicationsY. Koyama, M. J. Lear, F. Yoshimura, I. Ohashi, T. Mashimo, M. Hirama, Org. Lett., 7, 267-270, (2005).T. Usuki, T. Mita, M. J. Lear, P. Das, K. Akiyama, F. Yoshimura, M. Inoue, S. Tero-Kubota, M. Hirama, Angew. Chem., Int. Ed., 43(6), 5249-5253, (2004).P. Das, T. Mita, M. J. Lear, M. Hirama, Chem. Commun., 2624-2625, (2002).S. Kobayashi, S. Ashizawa, Y. Takahashi, Y. Suigura, M. Nagaoka, M. J. Lear , M. Hirama ,J. Am. Chem. Soc., 123(45), 11294-11295, (2001).M. J. Lear, F. Yoshimura, M., Angew. Chem., Int. Ed. , 40(5), 946-949, (2001).
Postdoc., Tohoku University, 2000
Postdoc., Parke-Davis & CNRS, 1997
Ph.D., University of Glasgow, 1995
B.Sc., University of Glasgow, 1991
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/lear.htm
Martin J Lear
20
Research FocusResearch Focus• Atmospheric Science • Computational Chemistry
Representative PublicationsRepresentative PublicationsO. Morgenstern, A.M. Lee, J.A. Pyle, J. Geophys. Res., 108, doi:10.1029/2002JD002098, (2003). A.M. Lee, R.L. Jones, I. Kilbane-Dawe, J.A. Pyle, J.Geophys. Res., 107, doi:10.1029/2001 JD000538, (2002). A.M. Lee, H.K. Roscoe, A.E. Jones, P.H. Haynes, E.F. Shuckburgh, M.W. Morrey, H.C. Pumphrey, J. Geophys. Res., bf 106, 3203-3211, (2001). A.M. Lee, H.K. Roscoe, S. Oltmans, Geophys. Res. Lett., 27, 3845-3848, (2000).A.M. Lee, G.D. Carver, M.P. Chipperfield, J.A. Pyle, J. Geophys. Res., 102, 3905-3919, (1997).
Singapore Millennium Found-ation Fellow, National University of Singapore, 2002-2004
Postdoc., University of Cambridge, 2002
Ph.D., University of Cambridge, 1997
M.A., University of Cambridge, 1996
B.A., University of Cambridge, 1992
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/aml.htm
21
Adria
n M L
ee
Research FocusResearch Focus• Separation science • Environmental analysis
Recent HighlightsRecent HighlightsReferenceX. Jiang, H.K. Lee, Anal. Chem, 76, 5591-5596, (2004).
SynopsisIn our quest to develop environmentally-friendly solvent-minimized analytical techniques, this recent paper reflects our philosophy. About 5 μL of organic solvent is trapped within a short length of hollow fibremembrane sealed at both ends. The “solvent bar” is immersed in an aqueous sample solution, and used for extraction of chlorobenzenes.
Representative PublicationsRepresentative PublicationsG. Shen, H.K. Lee, Anal. Chem. 74, 648-654, (2002).Y. He, H.K. Lee, Anal. Chem. 71, 995-1001, (1999).Y. Wang, Y.C. Kwok, Y. He, H.K. Lee, Anal. Chem.,70, 4610-4614, (1998).Y. He, H.K. Lee, Anal. Chem , 69, 4634-4640, (1997).K.K. Chee, M.K. Wong, H.K. Lee, J. Chromatogr. A, 723, 259-271, (1996).
Ph.D., University of Canterbury, New Zealand, 1982
B.Sc., University of Canterbury, New Zealand, 1978
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/leehk.htm
MAJOR RECOGNITIONEditor, Analytica Chimica Acta, 2005
Member, Editorial Board, Journal of Chromatography A, 2004
Member, International Advisory Board, Analyst, 1997
22
Lee HianK
ee
Research FocusResearch Focus• Control and kinetics of the Maillard reaction• Antioxidants in foods
Recent HighlightsRecent HighlightsReferenceG. Shui, L.P. Leong, Journal of Chromatography A. 1022 (1-2), 67-75, (2004).
SynopsisAntioxidants from natural extracts can be identified by its reaction with radicals or oxidizing agent. By comparison of chromatograms from LC-MS before and after reaction with radicals, antioxidants can be identified and characterized. Antioxidants can also be further analyzed for its efficiency and capacity by collecting the relevant fractions.
Representative PublicationsRepresentative PublicationsL.P. Leong, G. Shui, Food Chemistry, 76, 69-75 (2002).G. Shui, L.P. Leong, Journal of Chromatography A., 1022 (1-2), 67-75, (2004).G.H. Shui, L.P. Leong, Free Radical Biology And Medicine, 35, 130 Suppl. 1, (2003).G. Shui, L.P Leong, Journal of Chromatography A., 977, 89-96, (2002).L.P. Leong, B.L. Wedzicha, Food Chem., 68(1), 21-28, (2000).
Ph.D., University of Leeds, 2000
M.Sc., University of Leeds, 1996
B.Sc., Universiti KebangsaanMalaysia, 1995
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/leonglp.htm
Minutes10 20 30 40 50 60
mAU
0
250
500
750
23
Leon
gLai
Peng
Research FocusResearch Focus• Organometallic chemistry • Bioorganometallic chemistry
Recent HighlightsRecent HighlightsReferenceK.H. Chan, W.K. Leong, K.H.G. Mak, Organometallics, in press.
SynopsisThermolysis of the clusters Os3(CO)11(SbMe2Ar) in refluxing octane gave the benzyne clusters Os3(μ-SbMe2)(μ-H)(μ3,η2-C6H3R)(CO)9 in good yields. The higher-nuclearity cluster Os6(m4-Sb)(m-SbMe2)(μ-H)(μ3,η2-C6H4)2(CH3)(CO)16, which contained an Os-CH3 moiety, was also obtained. Thermolysis of the 3,5-xylyl analogue gave the unusual species Os3(μ-SbMe2)(μ3,η1,η2,η2-C6H3Me2)(CO)9, in which orthometallation of the xylyl ring has apparently been arrested
Representative PublicationsRepresentative PublicationsK.H. Chan, W.K. Leong, K.H.G. Mak. Organometallics, in press.V.S. Sridevi, W.K. Leong, Y. Zhu. Organometallics, in press.Q. Lin , W.K. Leong, Organometallics, 22, 3639-48 (2003).G. Chen, M. Deng, C.K. Lee , W.K. Leong, Organometallics, 21, 1227-34 (2002).M. Deng , W.K. Leong. Organometallics, 21, 1221 (2002).
Ph.D., Simon Fraser University, 1995
M.Sc., National University of Singapore, 1992
M.A., Cambridge University, 1986
Dip. Ed., National Institute of Education, 1985
B.A., Cambridge, 1982
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/leongwk.htm LeongW
engKee
SbMe2
Os
OsOs
Δ
MeMe
OsOs
OsSb
Me
Me
CH3
H3C
24
Li F
ong Y
auSa
mResearch FocusResearch Focus• Capillary electrophoresis • Nanoscale analysis
Recent HighlightsRecent HighlightsReferenceL.J. Yu, Y. Xu, H.T. Feng, S.F.Y. Li, Electrophoresis, 26(17), 3397-3404, (2005).
SynopsisA micellar electrokinetic chromatography (MEKC) method was developed for the separation and determination of toxic pyrrolizidinealkaloids (PAs). The method was applied in the determination of toxic alkaloids extracted from Chinese herbal medicines. The results obtained indicate that the proposed MEKC method could potentially become an effective alternative tool for qualification control and quantitative analysis of herbal medicines in pharmaceutical industry.
Representative PublicationsRepresentative PublicationsI. Rodriguez, L.J. Jin, S.F.Y. Li, Electrophoresis, 21(1), 211-219, (2000).P.K.H. Ho, J.S. Kim, J.H. Burroughes, H. Becker, S.F.Y. Li, T.M. Brown, F. Cacialli, R.H. Friend, Nature, 404(6777), 481-484 (2000).A.P. Fang, H. Ng, X.D. Su, S.F.Y. Li, Langmuir, 16(12), 5221-5226, (2000).K. Li, S.F.Y. Li, Analyst 120(2), 361-366, (1995).C.P. Ong, C.L. Ng, N.C. Chong, H.K. Lee, S.F.Y. Li, Journal Of Chromatography 516(1), 263-270, (1990).
D.Sc., Imperial College, 1998
Ph.D., Imperial College, 1984
B.Sc., Imperial College, 1981
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/lifys.htm
MAJOR RECOGNITIONEditorial Advisory Board, Electrophoresis, Germany, 2001Editorial Advisory Board, LC-GC Asia Pacific, USA, 2000
Editorial Advisory Board, Biomedical Chromatography, UK, 1999
Outstanding University Researcher, National University of Singapore, 1999
Editorial Advisory Board, Journal of Chromatographic Science, USA, 1997
DuPont Accomplishment Award, DuPont, 1993
25
Research FocusResearch Focus• Nuclear acid chemistry
Recent HighlightsRecent HighlightsSynopsisThe primary focus of my group in recent years has been directed toward the exploration of new properties of G-quadruplex and i-motif as well as their diagnostic and therapeutic applications. Several circularly unimolecular and bimolecular G-quadruplex and i-motif have accordingly been made in our lab in the past years while preparation of fluorescence-tagged circular G-quadruplex and i-motif are currently in progress. We hope that circular G-quadruplex and i-motif could be useful molecular tools for interfering certain biological functions of tetraplex-binding proteins and for examining the winding and resolving mechanisms of G-quadruplex catalyzed by G-quadruplex-promoting and disintegrating proteins.
Representative PublicationsRepresentative PublicationsD. Liu, J. Chen, A.H.F. Lee, L.M.C. Chow, A.S.C. Chan, T.H. Li, Angew. Chem., Int. Ed. Engl., 42(7), 797-799, (2003).A.H.F. Lee, A.S.C. Chan, T.H. Li, Tetrahedron, 59, 833-839, (2003).J. Qi, T.H. Li, A.S.C. Chan, Bioorganic & Medicinal Chemistry Letters, 13(20), 3561-3563, (2003).A.H.F. Lee, J. Chen, D. Liu, T.Y.C. Leung, A.S.C. Chan, T.H. Li, Journal of the American Chemical Society, 124(47), 13972-13973, (2002).A.H.F. Lee, A.S.C. Chan, T.H. Li, Chemical Communications (Cambridge, United Kingdom), 18, 2112-2113, (2002).
Postdoc., Scripps Research Institute, 1994
Ph.D., State University of New York, 1992
M.Sc., Beijing Institute of Chemical Technology, 1982
B.Sc., Jilin University, 1980
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/lth.htm
Li Tianhu
26
LohK
ianPi
ngResearch FocusResearch Focus• Surface chemistry of diamond and related materials• Synthesis and applications of nanomaterials
Recent HighlightsRecent HighlightsReferenceH.Q. Le, S.J. Chua, Y.W. Koh, K.P. Loh, Applied Physics Letter, (10): Art. No. 101908, (2005).
SynopsisWe used hydrothermal synthesis to fabricate aligned single crystalline ZnO nanorods on Gallium Nitride, under catalyst-free conditions. This is ZnO on GaN epitaxial growth.
Representative PublicationsRepresentative PublicationsW.C. Poh, K.P. Loh, W. De Zhang, Langmuir, 20 (13), 5484-5492, (2004).H.R. Gu, X. di Su, K.P. Loh, Journal of Physical Chemistry B, 109 (28), 13611-13618, (2005).J.M. Soon, C.W. Lim, K.P. Loh, Physical Review B, 72 (11), 115343, (2005).Y.W. Koh, M. Lin, C.K. Tan, K.P. Loh, Journal of Physical Chemistry B, 108 (31), 11419-11425, (2004).Y.W. Koh, C.S. Lai, A.Y. Du, K.P. Loh, Chemistry Of Materials, 15 (24), 4544-4554, (2003).
Postdoc., National Institute for Material Science, Tsukuba, Japan, 1998
Ph.D., Oxford University, 1996
B.Sc., National University of Singapore, 1994
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/lohkp.htm
MAJOR RECOGNITIONNippon Sheet Glass Foundation, Japan, 2000
(a)(a)
0.5μm
(b)
GaN
Sapphire 0.5μm0.5μm
(b)
GaN
Sapphire
27
Research FocusResearch Focus• Asymmetric catalysis/Green chemistry • Medicinal Chemistry (analgesics, anti-cancer agents,
antibiotics)
Recent HighlightsRecent HighlightsReferenceY. Lu, , G. Just, Angew. Chem. Int. Ed. Engl. 2000, 39, 4521-24; Angew. Chem, 112, 4695-98, (2000).
SynopsisRp and Sp dithymidine phosphorothioates with 95% de was prepared using chiral indolo-oxazaphosphorine intermediates derived from tryptophan, the synthesis was carried out both in solution and on solid support .
Representative PublicationsRepresentative PublicationsM. Manoharan, Y. Lu, M.D. Casper, G. Just, Org. Lett. , 2, 243-246, (2000).Y. Lu, G. Just, Angew. Chem. Int. Ed. Engl. 2000, 39, 4521-24; Angew. Chem, 112, 4695-98, (2000).Y. Lu, T.M.-D. Nguyen, G Weltrowska, I. Berezowska, C. Lemieux, N.N. Chung, J. Med. Chem. (an expedited article), 44, 3048-3053, (2001).P.W. Schiller, G. Weltrowska, T.M.-D. Nguyen, C. Lemieux, N.N. Chung, Y. Lu, Life Sciences, 73, 691 -698, (2003).
Postdoc., Nagoya University, Japan, 2001
Postdoc., Clinical Research Institute of Montreal, Canada, 2000
Ph.D., McGill University, 2000
B.Sc., Fudan University, 1991
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/luxy.htm
Lu Yixin
PO S
O
O
OHO T
OH
O TNH
N
HO
Bn
O
N
NH4
(95% de)
28
Mak
Ka W
aiK
arenResearch FocusResearch Focus• Enzyme sensor for environmental analytes • Substrate recycling in multi-enzyme system
Representative PublicationsRepresentative PublicationsK.K.W. Mak, A.W.C. Law, S. Tokuda, H. Yanase, R. Renneberg, Appl Microbiol Biotechnol, 67, 631-636, (2005).K.K.W. Mak, H. Yanase, R. Renneberg, Microchimica Acta, 149, 131-135, (2005).R.C.H. Kwan, P.Y.T. Hon, K.K.W. Mak, R. Renneberg, Biosensors and Bioelectronics ,19, 1745-1752, (2004).K.K.W. Mak, U. Wollenberger, F. Scheller, R. Renneberg, Biosensors and Bioelectronics, 18, 1095-1100, (2003).
S.C.K. Lau, K.K.W. Mak, F. Chen, P. Qian, Mar Ecol Prog Ser, 226, 301-310, (2002).
Postdoc., Hong Kong University of Science and Technology, 2004
Ph.D., Hong Kong University of Science and Technology, 2003
B.Sc., Hong Kong University of Science and Technology, 1999
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/mak.htm
29
Research FocusResearch Focus• Bioactive plant foods and extracts derived from natural health
products and traditional food sources • Dietary saponins from ginseng (ginsenosides), bitter melon and
soy)
Recent HighlightsRecent HighlightsReferenceD.G. Popovich, D.D. Kitts, Phytochemistry, 65, 337-344, (2004).
SynopsisGinsenosides Rh2 and Rg3 are rare bioactive ginsenosides and were effectively shown to be a breakdown product of thermal extraction of ginseng plant material, an underutilized resource, and is potential source for natural health products or pharmaceutical development.
Representative PublicationsRepresentative PublicationsD.G. Popovich, D.D. Kitts, Phytochemistry, 65, 337-344, (2004). D.G. Popovich, D.D. Kitts, Arch.Biochem Biophys, 406, 1-8, (2002).D.G. Popovich, D.D. Kitts, J. Biochem. Mol. Toxicol, 18(3), 143-149, (2004).D.G. Popovich, D.D. Kitts, Can. J. Physiol. Pharmacol, 82, 183–190, (2004).D.J. Jenkins, D.G. Popovich, C.W. Kendall, E. Vidgen, N. Tariq, T.P.P. Ransom, T.M.S. Wolever, V. Vuksan, C.C. Mehling, D.L. Boctor, C. Bolognesi, J. Huang, R. Patten, Metabolism, 46(6), 1-4, (1997).
Postdoc., NSERC, Vancouver 2005
Postdoc., University of British Columbia, 2004
Ph.D., University of British Columbia, 2004
M.Sc., University of Toronto, 1996
B.Sc., University of Toronto, 1991
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/popovich.htm David G Popovich
30
Sim
Wee
Sun
Research FocusResearch Focus• Surface Science and catalysis • Thin Films and nanomaterials
Recent HighlightsRecent HighlightsReferenceB.S. Yeo, Z.H. Chen, W.S. Sim, Surface Science, 557, 201, (2004).
SynopsisThe efficient growth of ordered thin oxide films on Ni(111) using low NO2 gas exposures under ultrahigh vacuum conditions has been achieved. Auger electron spectroscopy and low energy electron diffraction reveal the creation of an intermediate NiO(100) phase, followed by the eventual formation of clean NiO(111) overlayers. Reflection absorption infrared spectroscopy using CO molecules as probes of the surface adsorption sites present confirms the conversion of Ni0 to Ni2+ during the oxidation process.
Representative PublicationsRepresentative PublicationsB.S. Yeo, Z.H. Chen, W.S. Sim, Langmuir , 19, 2787, (2003).W.S. Sim, T.C. Li, P.X. Yang, B.S. Yeo, Journal of the American Chemical Society 124, 4970, (2002).F. Tao, W.S. Sim, G.Q. Xu, M.H. Qiao, Journal of the American Chemical Society 123, 9397, (2001).W.S. Sim, P. Gardner, D.A. King, Journal of the American Chemical Society, 118, 9953, (1996).W.S. Sim, D.A. King, Journal of the American Chemical Society, 117, 10583, (1995).
Postdoc., University of Cambridge, 1997
Ph.D., University of Cambridge, 1996
B.Sc. (Honours), National University of Singapore , 1992
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/simws.htm
MAJOR RECOGNITIONSNAS Young Scientist Award, Singapore National Academy of Science/A*STAR, 2002
DuPont Young Faculty Award, Dupont, 2001
31
Research FocusResearch Focus• Polymer/Material chemistry
Recent HighlightsRecent HighlightsSynopsisOur studies of polymer blends include the basic problem of blendmiscibility as well as the applications of polymer blends. We are working on the preparation of new epoxy resin modifiers by blending rubber with thermoplastic polymers.
Representative PublicationsRepresentative PublicationsX.P. Hou, K.S. Siow, Polymer, 41, 8689-8696 (2000).W. Xu, K.S. Siow, Z.Q. Gao, J. Electrochem. Soc., 146, 4410-4418 (1999).X.P. Hou, K.S. Siow, Z.Q. Gao, J. Solid State Electr., 3, 387-391 (1999). W. Xu, K.S. Siow, Z.Q. Gao, Langmuir, 15, 4812-4819 (1999).
H.B. Wang, K.S. Siow, Polym. Eng. Sci., 39, 422-429 (1999).
Ph.D., McGill University, 1972
M.Sc., Simon Fraser University, 1968
B.Sc., Nanyang University, 1965
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/siowks.htm
SiowK
okSiong
32
Tan C
hoon
Hon
gResearch FocusResearch Focus• Synthetic organic chemistry • Biological chemistry
Recent HighlightsRecent HighlightsReferenceW. Ye, D. Leow, S.L.M. Goh, C.-T. Tan, C.-H. Chian, C.-H. Tan, Tetrahedron Letters, in press.
SynopsisA series of chiral bicyclic guanidines, either symmetrical or non-symmetrical, was synthesized using a concise and efficient aziridine-based synthetic methodology. Starting from commercial amino alcohols, five synthetic steps were performed, with only three requiring chromatographic purification, giving the desired guanidines in 43-71% overall yield. Preliminary studies using these guanidines showed moderate enantioselectivity for several Michael reactions.
Representative PublicationsRepresentative PublicationsW. Ye, D. Leow, S.L.M. Goh, C.-T. Tan, C.-H. Chian, C.-H. Tan, Tetrahedron Letters, in press.W. Ye, J. Xu, C.T. Tan, C.H.Tan, Tetrahedron Letters, 46, 6875-6878, (2005).C.H. Tan, Y. Kobayashi , Y. Kishi. Angewandte Chemie International Edition English, 39, 4282-4284, (2000).Y.Kobayashi, C.H.Tan and Y.Kishi., Journal of the American Chemical Society, 123, 2076-2078, (2001).C.H.Tan and A.B.Holmes., A European Journal, 7, 1845-1854, (2001) .
Postdoc., Harvard University, 2002
Ph.D., University of Cambridge, 1999
B.Sc. (Honours), National University of Singapore, 1996
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/tanch.htm
N
R
Ts
NTsHN NHTs
RR
R'
N
NH
RN
R
33
Research FocusResearch Focus• Bioanalytical-electroanalytical chemistry • Electrochemical materials
Recent HighlightsRecent HighlightsReferenceL. He, C.S. Toh, Anal. Chim. Acta, in press.
SynopsisApplications of materials in analytical chemistry are reviewed, with focus on sensors, separations and extraction techniques. This review aims to survey examples of interesting works carried out in the last five years over a broad spectrum of materials classified as hybrids, nanomaterials and biomolecular materials .
Representative PublicationsRepresentative PublicationsL.Y. Liu , C.S. Toh, “Chemical modification of nanoporous alumina membranes” U.S. Patent pending.L. He , C.S. Toh, Anal. Chim. Acta (in press).C.S. Toh, B.M. Kayes, E.J. Nemanick , N.S. Lewis, Nanoletters, 4, 767-770.C.S. Toh, P.N. Bartlett, N. Mano, F. Aussenac, A. Kuhn, E.J. Dufourc, Physical Chemistry and Chemical Physics, 5, 588-593, (2003).P.N. Bartlett, P. R. Birkin, M. A. Ghanem , C.S. Toh, Journal of Materials Chemistry, 11, 849-853 (2001).
Postdoc., California Institute of Technology, 2004
Ph.D., University of Southampton, 2002
M.Sc., National University of Singapore, 1995
B.Sc. (Honours), National University of Singapore, 1993
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/tohcs.htm
TohCheeSeng
34
Valiy
aveet
tilSu
resh
Research FocusResearch Focus• Organic/Polymer materials • Bio(nano)materials and nanotechnology
Recent HighlightsRecent HighlightsReferenceP.K. Ajikumar, S. Vivekanandan, R. Laxminarayanan, S.D.S. Jois, R.M. Kini, S. Valiyaveettil, Angewandte Chem., 44, 5476-5479, (2005).
SynopsisStructure-property relationship of a series of designer peptides towards the biomineralization process is investigated using various experimental techniques.
Representative PublicationsRepresentative PublicationsM. Vetrichelvan, S. Valiyaveettil, Chem. Eur. J., 11, 5889-5898, (2005).P.K. Ajikumar, S. Vivekanandan, R. Laxminarayanan, S.D.S. Jois, R.M. Kini, S. Valiyaveettil, Angewandte Chem., 44, 5476-5479, (2005).S. Jegadesan, R.C. Advincula, S. Valiyaveettil, Nanolithographic, Advanced Materials, 17, 1282-1285, (2005).R. Lakshminarayanan , E.C. Ooi, X.J. Loh, , R.M. Kini, S. Valiyaveettil, Biomacromolecules, 6(3), 1429-1437, (2005).R. Lakshminarayanan, R.M. Kini, S. Valiyaveettil, PNAS, 99(8), 5155-5159, (2002).
Postdoc., Max-Planck Institute for Polymer Research, 1997
Postdoc., University of Twente, 1992
Ph.D., University of Victoria, 1992
M.Tech., Indian Institute of Technology, 1987
M.Sc., Calicut University, 1985
B.Sc., Calicut University, 1983
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/suresh.htm
8.5 6.57.5 ppm
R2E2W2D2P-17
K2E2W2D2P-17
K2E2W2D2G-17
R2E2W2D2-16
K2E2W2D2-16
(KE)2(WD)2-16
K2AE2AW2AD2P-23
8.5 6.57.5 ppm
R2E2W2D2P-17
K2E2W2D2P-17
K2E2W2D2G-17
R2E2W2D2-16
K2E2W2D2-16
(KE)2(WD)2-16
K2AE2AW2AD2P-23
B C
D E
35
Research FocusResearch Focus• Inorganic chemistry & Inorganic materials• Supramolecular chemistry & crystal engineering
Recent HighlightsRecent HighlightsSynopsisA one-dimensional coordination polymer, [{(F3CCO2)(µ-O2CCH3)Zn}2(µ-bpe)2]n (bpe = 4,4’-bipyridylethylene) with molecular ladder structure undergoes [2+2] photochemical cycloaddition across the rails to form [[{(F3CCO2)(µ-O2CCH3)Zn}2(µ-tpcb)2]n (tpcb = rctt-tetrakis(4-pyridyl)-cyclobutane), in up to 100% yield accompanied by single-crystal to single-crystal transformation.
Representative PublicationsRepresentative PublicationsM.T. Ng, C..Boothroyd, J.J. Vittal. Chem. Commun., 3820-3822, (2005). N.L. Toh, M. Nagarathinam , J.J. Vittal. Angew. Chem. Int. Ed. Engl., 44, 2237-2241, (2005).B. Sreenivasulu, J.J. Vittal. Angew. Chem. Int. Ed. Engl., 43, 5769-5772, (2004).C.-T. Yang, M. Vetrichelvan, X. Yang, B. Moubaraki, Dalton Trans., 113-121, (2004). M. Lin, K.P. Loh, T.C. Deivaraj, J.J. Vittal, Chem. Commun., 1400-1401, (2002).
Postdoc., University of Western Ontario, 1987
Ph.D., Indian Institute of Science, 1982
M.Sc., Madurai University, 1977
B.Sc., University of Madras, 1975
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/jjvittal.htm
MAJOR RECOGNITIONBronze Medal of the Indian Association of Solid State Chemists and Allied Scientists, 2001
Award for International Authors, Royal Society of Chemistry Journal Grant, 2002
Member, International Editorial Board of Main Group Metal Chemistry
Book ‘Frontiers in Crystal Engineering’, edited by Edward R.T. Tiekink and J.J. Vittal, Wiley & Sons, Ltd. Feb. 2006, ISBN: 0-470-02258-2.
JagadeseJ Vittal
36
Wen
gZhiq
iang
Research FocusResearch Focus• Transition metal catalysts for olefin oligomerization/
polymerization • Transition metal catalysts for organic synthesis
Recent HighlightsRecent HighlightsReferenceZ. Weng, S. Teo, L.L. Koh, T.S.A. Hor, Organometallics, 23, 4342, (2004).
SynopsisA mixture of Pd2(dba)3 and hemilabile ferrocenyl ligand [η-C5H4CH=N(C6H5)]Fe[η-C5H4P(t-Bu)2], efficiently catalyzes the Suzukicross-couplings of a range of arylboronic acids and aryl chlorides, affording the desired biaryl products in high isolated yields. One of catalytically active 14-e linear Pd(0) intermediate, Pd{[η-C5H4CH=N(C6H5)]Fe[η-C5H4P(t-Bu)2]}2, has been isolated and crystallographically established.
Representative PublicationsRepresentative PublicationsZ. Weng, S. Teo, L.L. Koh, T.S.A. Hor, Angew. Chem. Int. Ed., 44, 7560, (2005).Z. Weng, S. Teo, L.L. Koh, T.S.A. Hor, Organometallics, 23, 4342, (2004).Z. Weng, S. Teo, L.L. Koh, T.S.A. Hor, Organometallics , 23, 3603, (2004).Z. Weng, L.Y. Goh, Acc. Chem. Res., 37, 187, (2004).L.Y. Goh, Z. Weng, W.K. Leong, J.J. Vittal, J. Am. Chem. Soc., 124, 8804, (2002) .
Ph.D., National University of Singapore, 2003
B.Sc., Fuzhou University, 1994
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/wengzq.htm
37
Research FocusResearch Focus• Biophysical fluorescence
Recent HighlightsRecent HighlightsSynopsisThe research in my group is directed towards biophysics with an emphasis on biophysical fluorescence. With the fluorescence tools developed in our group we hope to shed some light on this question by in vitro experiments. In a complementary approach we will study the proteins in living cells because proteins are in many cases very sensitive to their environment and only when studied under physiological conditions can we determine their exact function.
Representative PublicationsRepresentative PublicationsL.C. Hwang, T. Wohland, JCP, 122, 114708 (2005). P. Li, T. Wohland, B. Ho, J.L. Ding, JBC, 279(48), 5150-56 (2004).L. Yu, H. Bow, J.L. Ding, T. Wohland, J. Teknologi F, 41, 101-112 (2004).L.C. Hwang, T. Wohland, ChemPhysChem, 5, 549-551 (2004).H. Pick, A.K. Preuss, M. Mayer, T. Wohland, R. Hovius, H. Vogel, Biochemistry, 42(4), 877-884 (2003).
Postdoc., Stanford University
Ph.D., Swiss Federel Institute of Technology at Lausanne
Dipl. Phys., University of Heidelberg
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/tw.htm
38
ThorstenWohland
Won
g Ming
Wah
Rich
ard
Research FocusResearch Focus• Computational quantum chemistry • Organic reaction mechanism & reactive intermediates
Recent HighlightsRecent HighlightsReferenceM.W. Wong, R. Steudel, Chem. Commun, 3712-3714, (2005).
SynopsisHigher-level ab initio calculations showed that the global energy minimum for both S3O and S3O·+ is a branched three-membered ring. This is sharp contrast to previous claim that S3O and S3O·+ have an open chain form.
Representative PublicationsRepresentative PublicationsM.W. Wong, R. Steudel, Chem. Commun. 3712-3714, (2005).M.W. Wong, R. Steudel, Chem. Eur. J. 11 1281-1293, (2005).M.W. Wong, J. Org. Chem. 70, 5487-5493, (2005).A.M. Mak, M.W. Wong, Chem. Phys. Lett. 403, 192-197, (2005).C.T. Wong, M.W. Wong, J. Org. Chem. 70, 124-131, (2005).
Postdoc., Yale University, 1991
Postdoc., IBM Kingston, 1990
Ph.D., Australian National University, 1989
B.Sc. & B.Math, University of Newcastle, 1985
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/wongmw.htm
MAJOR RECOGNITIONAustralian Research Fellow, Australian Research Council, 1992
Outstanding University Award, National University of Singapore, 2002
International Board Member, Asian Pacific Association of Theoretical & Computational Chemists, 2004
SS
O
S S S
O
S
S3O and S3O.+: or
branched ring chain
?
39
Research FocusResearch Focus• Surface chemistry• Nano-materials and molecular conductivity
Recent HighlightsRecent HighlightsReferenceF. Tao, G.Q. Xu, Accounts of Chemical Research, 37(11), 882-893 (2004).
SynopsisMolecular attachment chemistry is emerging as an important approach to tailor the chemical, physical and mechanical properties of silicon surfaces as well as for incorporating organic functions into silicon-based devices for various technological needs. This article reviews the recent progress and current understanding of reactivity, selectivity and mechanisms of organic molecules on Si(111)-7×7.
Representative PublicationsRepresentative PublicationsF. Tao, Z.H. Wang, Y.H. Lai, G.Q. Xu, Journal of The American Chemical Society, 125(22), 6687-6696, (2003).F. Tao, X.F. Chen, Z.H. Wang, G.Q. Xu, Journal of The American Chemical Society, 124(24), 7170-7180 (2002).F. Tao, W.S. Sim, G.Q. Xu GQ, M.H. Qiao, Journal of The American Chemical Society, 123(38), 9397-9403 (2001).Y. Cao, Z.H. Wang, D.F. Deng, G.Q. Xu, Angewandte Chemie-International Edition, 39(15), 2740-2743(2000).Y. Cao, K.S. Yong, Z.Q. Wang, W.S. Chin, Y.H. Lai, J.F. Deng, G.Q. Xu GQ, Journal of The American Chemical Society, 122(8), 1812-1813 (2000)
Postdoc., University of Toronto, 1991
Postdoc., Brookhaven National Lab, 1989
Ph.D., Princeton University, 1987
B.Sc., Fudan University, 1982
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/xugq.htm
MAJOR RECOGNITIONNational Youth Award for excellence in science and technology, National Youth Council, 1997
XuGuoQin
40
XuQi
nghu
aResearch FocusResearch Focus• Optical spectroscopy and imaging • Material physics and biophysics
Recent HighlightsRecent HighlightsReferenceQ.-H. Xu, B.S. Gaylord, S. Wang, G.C. Bazan, D. Moses, A.J. Heeger, PNAS, 101(32), 11634, (2004).
SynopsisUltrafast two-pulse fluorescence modulation spectroscopy was used to investigate the FRET processes in the application of conjugated polymers in DNA sensors. This technique provides solvent response free signal with fs resolution and can be utilized to study dynamical processes in extremely dilute solutions. The roles of hydrophobic and electrostatic interactions in the DNA sensors were investigated.
Representative PublicationsRepresentative PublicationsQ.-H. Xu, S. Wang, K. Dmitry, A. Mikhailovsky, G.C. Bazan, D. Moses, A.J. Heeger, PNAS, 102 (3), 530, (2005).Q.-H. Xu, B.S. Gaylord, S. Wang, G.C. Bazan, D. Moses, A.J. Heeger, PNAS ,101(32), 11634, (2004).K.A. Merchant, Q.-H. Xu, D.E. Thompson, M.D. Fayer, J. Phys. Chem. A, 106(38), 8839, (2002).Q.-H. Xu, Y.-Z. Ma, G.R. Fleming, J. Phys. Chem. A. , 106(45), 10755, (2002).Q.-H. Xu, Y.-Z. Ma, G.R Fleming, Chem. Phys. Lett., 338(4-6), 254, (2001).
Postdoc., UC Santa Barbara, 2005
Postdoc., Stanford University , 2002
Ph.D., UC Berkeley, 2001
B.Sc., Zhejiang University, 1993
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/xuqh.htm
41
Research FocusResearch Focus• Crystal engineering, supramolecular chemistry• Protein crystallography, structural biology
Recent HighlightsRecent HighlightsReferenceT.C.W. Mak, F. Xue, J. Am. Chem. Soc., 122, 9860-9861, (2000).
SynopsisThe design and construction of hydrogen-bonded "supramolecularrosettes" from guanidinium / organic sulfonate, trimesic acid, or cyanuric acid / melamine depend on utilization of their topological equivalence, i.e., equal numbers of donor and acceptor hydrogen-bonding sites and C3 symmetry of the component moieties .
Representative PublicationsRepresentative PublicationsC.-K. Lam, F. Xue, J.-P. Zhang, X.-M. Chen, T.C.W. Mak, J. Am. Chem. Soc., 127, 11536-11537, (2005).R. Thaimattam, F. Xue, J.A.R.P. Sarma, T.C.W. Mak, G.R. Desiraju, J. Am. Chem. Soc., 123, 4432-4445, (2001).T.C.W. Mak, F. Xue, J. Am. Chem. Soc., 122, 9860-9861, (2000).F. Xue, T.C.W. Mak, Acta Crystallogr. B, 56, 142-154, (2000).F. Xue, T.C.W. Mak, J. Phys. Org. Chem., 13, 405-414, (2000).
Postdoc., The Wistar Institute, 2005
Ph.D., The Chinese University of Hong Kong, 2000
B.Sc., Tsinghua University , 1993
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/xf.htm
XueFeng
42
YaoS
haoQ
inResearch FocusResearch Focus• Chemical biology • Medicinal chemistry
Recent HighlightsRecent HighlightsReferenceY. Hu, G.Y.J. Chen, S.Q. Yao, Angew. Chem. Intl. Ed., 44, 1048-1053, (2005).
SynopsisExpression Display allows genome-wide expression of proteins from cDNA sources, which upon functional selection using activity-based probes, enable high-throughput identifications and characterizations of a variety of enzymes (on the basis of their catalytic activities) through hybridization and decoding with a DNA microarray.
Representative PublicationsRepresentative PublicationsY. Hu, G.Y.J. Chen, S.Q. Yao, Angew. Chem. Intl. Ed., 44, 1048-1053, (2005).M. Uttamchandani, D.P. Walsh, S.Q. Yao, Y.T. Chang, Curr. Opin. Chem. Biol., 9, 4-13, (2005).E.W.S. Chan, S. Chattopadhaya, R.C. Panicker, X. Huang, S.Q. Yao, J. Am. Chem. Soc., 126, 14435-14446, (2004).R.Y.P. Lue, G.Y.P. Chen, Y. Hu, Q. Zhu, S.Q. Yao, J. Am. Chem. Soc., 126, 1055-1062, (2004).M.L. Lesaicherre, R.Y.P. Lue, G.Y.P. Chen, Q. Zhu, S.Q. Yao, J. Am. Chem. Soc., 124, 8768-8769, (2002).
Postdoc., Scripps Research Institute, 2001
Postdoc., University of California Berkeley, 1999
Ph.D., Purdue University, 1998
B.Sc., Ohio State University, 1993
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/yaosq.htm
MAJOR RECOGNITIONScientific Advisory Board,Molecular BioSystems, 2005
Young Researcher Award, National University of Singapore, 2005
Young Investigator Award, A*STAR, Singapore, 2002
43
Research FocusResearch Focus• Self-assembly of discrete and polymeric metallo-
supramolecular systems• Organometallic molecular wires
Recent HighlightsRecent HighlightsReferenceR. Lin, J.H.K. Yip, K. Zhang, L.L. Koh, K.Y. Wong, K.P. Ho, Journal of the American Chemical Society, 126, 15852-15869, (2004).
SynopsisThis paper is a comprehensive and in-depth study of, solution and solid state structures, electrochemistry, photophysics and host-guest chemistry of a novel gold rectangle which was synthesized from self-assembly of molecular clip [Au2(PAnP)]2+ and 4,4’-bipyridine.
Representative PublicationsRepresentative PublicationsR. Lin, J.H.K. Yip, K. Zhang, L.L. Koh, K.Y. Wong, K.P. Ho, Journal of the American Chemical Society, 126, 15852-15869, (2004).J.H.K. Yip, J. Prabhavathy, Angewandte Chemie International Edition, 40, 2159 – 2162, (2001). K. Zhang, J. Prabhavathy, J.H.K. Yip, L.L. Koh, G.K. Tan, J.J. Vittal, Journal of the American Chemical Society, 125, 8452-8453, (2003).J.H.K. Yip, J.G. Wu, K.Y. Wong, K.P. Ho, C. S. Pun, J.J. Vittal, Organometallics, 21, 5292-5233, (2002).J.H. K. Yip, Suwarno, J.J. Vittal, Inorganic Chemistry, 39, 3537-3543, (2000).
Postdoc., Caltech, 1997
Postdoc., Technical University of Munich, 1995
Ph.D., University of Hong Kong, 1993
B.Sc., University of Hong Kong, 1989
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/yipjohn.htm
MAJOR RECOGNITIONAlexander von Humboldt fellowship, Alexander von Humboldt Foundation, 1993
Yip Hon K
ay John
44
Zhou
Weib
iaoResearch FocusResearch Focus• Modeling, optimisation and advanced control of food
processes • Effect of processing on some functional components of food
Recent HighlightsRecent HighlightsReferenceS.Y. Wong, W. Zhou, J. Hua, Journal of Food Engineering, in press.
SynopsisThe robustness of a Computational Fluid Dynamics (CFD) model forbread baking to some uncertainties in the physical properties ofdough/bread is addressed in this paper. Temperature profiles at eight different locations in bread and oven were analyzed. Analysis of the experimental results showed that density and heat capacity were more influential factors.
Representative PublicationsRepresentative PublicationsN. Therdthai, W. Zhou, T. Adamczak, Journal of Food Engineering, 65(4), 599-608, (2004).R. Wang, W. Zhou, Journal of Agricultural and Food Chemistry, 52(26), 8224-8229, (2004).W. Zhou, International Journal of Computational Fluid Dynamics, 19(1), 73-77, (2005).W. Zhou, S. Dong, P.L. Lee, Computers & Chemical Engineering, 26(9), 1231-1239 (2002).N. Therdthai, W. ,Zhou, Journal of Food Engineering, 50(2), 107-111 (2001).
Postdoc., University of Waterloo , 1991
Ph.D., The University of Queensland, 1991
M.Eng, Chinese Academy of Sciences, 1985
B.Sc., Beijing University of Chemical Technology, 1982
WEBSITEhttp://www.chemistry.nus.edu.sg/ourpeople/academic_staff/zhouwb.htm
MAJOR RECOGNITIONMember, International Editorial Board, International Journal of Food Engineering
Member, Nominations Advisory Committee, Inter-national Union of Food Science & Technology (IUFoST), 2001-2003, 2003 -2006
45