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DEPARTMENT OF CHEMISTRY NEWSLETTER

Spring 2019

Message from the Chair Spring brings much excitement to Louisville with a flurry of activities including March Madness, the Derby Festival and Graduation. It also provides an excellent opportunity at the University to reflect on what we have accomplished as the academic year closes and we make plans for future adventures. It has been some time since we last provided an update to our alumni and friends on the happenings within the Department of Chemistry. This newsletter provides a glimpse of some of the wonderful activities happening within the Chemistry Building, the Shumaker Research Building, and now the new Belknap Academic Building. Whether you have been on campus recently or you have not seen the Belknap Campus in some time, I invite you browse this newsletter and catch-up with some familiar faces and meet some new ones. Hopefully, you will have the opportunity to participate in a department event or just stop by for a visit. Either way, keep up with the department on our new and improved webpage and by following us on our social media accounts on Facebook, Twitter and LinkedIn. Craig Grapperhaus, Professor and Chair

2019 Derby Lecture Series Each year, the Chemistry Graduate Student Association invites a prominent chemist (often, a Nobel Laureate) to the department as part of our Distinguished Lecture Series, known informally as the Derby Lectures. These lectures have acquired some cachet in the Chemistry community and contribute to departmental esprit de corps

This year, we are very pleased that we will once again be hosting the visit of a Nobel Laureate in Chemistry for our 2019 Derby Lecture Series. Sir J. Fraser Stoddart, who is a recipient of the 2016 Nobel Prize, will be on campus during Derby week to present the following two public lectures: A Technical Lecture, Thursday, May 2, 2:00 pm A General Audience Lecture, Friday, May 3, 11:30 am Both seminars will take place on Belknap campus in the UofL Gheens Science Hall and Rauch Planetarium and are open to the public. Professor Stoddart will be the 21st Nobel Laureate to participate in this lecture series, which is hosted by our Chemistry Graduate Student Association and supported in part by Clariant/Sud-Chemie, Inc.

This would be a great opportunity for you to come back to campus, visit with us in the Chemistry Department, and take a look at some of our new people and places. We’ll be providing coffee and donuts from 10 to 11 am in the Chem Building before the Friday talk and hope that some of you can stop by.

Department Committee The Department of Chemistry is putting together an advisory committee. The committee will assist the Department Leadership in shaping the future direction of the Department. If you are interested in serving on this committee, please contact Dr. Jason Sievers, Coordinator for the Department. He can be reached at jason.sievers@louisville.edu or 502-852-8150.

Check department website for specific lecture titles.

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Faculty Faculty 2018 Publications

* = High Impact

Angnes, R. A., Thompson, L. M., Mashuta, M. S., Correia, C. R. D., & Hammond, G. B. (2018). Non-Covalent Substrate Directed Enantioselective Heck Desymmetrization of cis-Cyclohex-4-ene-1,2- diol: Synthesis of all cis Chiral 5-Aryl-cyclohex-3-ene-1,2-diols and mechanistic investigation. Advanced Synthesis & Catalysis, Vol: 360 (19), pp: 3760-3767; DOI: 10.1002/adsc.201800826.

Bihani, M., Ansari, T., Smith, J. D., & Handa, S. (2018). The magical but endangered metal: Searching sustainable palladium catalysis. Curr. Opin. Green Sustainable Chem, Vol: 11, pp: 45-53; DOI: 10.1016/j.cogsc.2018.03.002.

Conklin, D. J., Ogunwale, M. A., Chen, Y., Nantz, M. H., Fu, X.-A., Riggs, D. W., Lorkiewicz, P., Bhatnagar, A., & Srivastava, S. (2018). Electronic Cigarette- Generated Aldehydes: The Contribution of e-Liquid Components to Their Formation and the Use of Urinary Aldehyde Metabolites as Biomarkers of Exposure. Aerosol Science and Technology, Vol: 52 (11), pp: 1219–1232; DOI: 10.1080/02786826.2018.1500013.

Deng, P., Higashi, R. M., Lane, A. N., Bruntz, R. C., Sun, R. C., Raju, M. V. R., Nantz, M. H., Qi, Z., & Fan, T. W.-M. (2018). Quantitative Profiling of Carbonyl Metabolites Directly in Crude Biological Extracts Using Chemoselective Tagging and nanoESI-FTMS. Analyst, Vol: 143 (1), pp: 311-322; DOI: 10.1039/C7AN01256J.

Ebule, R., Hammond, G. B., & Xu, B. (2018). Metal-free Chlorothiolation of Alkenes using HCl and Sulfoxides. Eur. J. Org. Chem., Vol: 2018 (34), pp: 4705-4708; DOI: 10.1002/ejoc.201800973.

Fanah, S. J., Yu, M., Huq, A., & Ramezanipour, F. (2018). Insight into Lithium-Ion Mobility in Li2La(TaTi)O7. Journal of Materials Chemistry A, Vol: 6 (44), pp: 22152–22160; DOI: 10.1039/C8TA05187A.

Finck, L., Brals, J., Pavuluri, B., Gallou, F., & Handa, S. (2018). Micelles-enabled photo- assisted selective oxyhalogenation of alkynes in water under mild conditions. Journal of Organic Chemistry, Vol: 83 (14), pp: 7366-7372; DOI: 10.1021/acs.joc.7b03143.

Gao, X., Liang, M., Fang, Y., Zhao, F., Tian, J., Zhang, X., & Qin, X. (2018). Deciphering the differential effective and toxic responses of Bupleuri Radix following the induction of chronic unpredictable mild stress and in healthy rats based on serum metabolic profiles. Frontiers in Pharmacology, Vol: 8 (995).

Gao, Y., Gao, L., Tian, J., Qin, X., & Zhang, X. (2018). A network pharmacology approach to decipher the mechanisms of anti-depression of Xiaoyaosan formula. World Journal of Traditional Chinese Medicine, Vol: 4 (4), pp: 147-162; DOI: 10.4103/wjtcm.wjtcm_20_18.

Ghosh, A. P., Al Mamun, A., Lodowski, P., Jaworska, M., & Kozlowski, P. M. (2018). Mechanism of the Photo-induced Activation of Co-C Bond in MethylcobalaminDependent Methionine Synthase. Journal of Photochemistry and Photobiology B, Vol: 189, pp: 306-317.

FACULTY HIGHLIGHT Dr. Sachin Handa came to UofL in 2016 and is the first native of India on the Chemistry faculty. He is originally from Patti, Amritsar, the "City of the Golden Temple" and more recently from Santa Barbara in the "Golden State" of California where he worked as a postdoctoral scholar for Prof. Bruce H. Lipshutz. In between, he continued his association with gold during his Ph.D. studies at Oklahoma State University where his dissertation title was on the "design and synthesis of novel ligands for tuning of selectivity and reaction pathway in gold catalysis." Sachin’s main fascination, however, is not with gold but rather with green, as is evidenced by his ongoing research focus on environmentally friendly synthetic methodologies and sustainable organic synthesis that mimics nature. Projects include nanodot catalysis in water, sustainable photoredox chemistry, and heterogeneous materials for organocatalysis.

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Faculty 2018 Publications (continued)

Handa, S., Ibrahim, F., Ansari, T., & Gallou, F. (2018). π-Allylpalladium species in micelles of FI-750-m for sustainable and general suzuki-miyaura couplings of unactivated quinoline systems in water. ChemCatChem, Vol: 10 (19), pp: 4229-4233; DOI: 10.1002/cctc.201800958

Handa, S., Smith, J. D., Zhang, Y., Gallou, F., & Lipshutz, B. H. (2018). Sustainable HandaPhos-ppm Palladium Technology for Copper-Free Sonogashira Couplings in Water under Mild Conditions. Organic Letters, Vol: 20 (3), pp: 542-545; DOI: 10.1021/acs.orglett.7b03621.

He, L., Prodhan, A. I., Yuan, F., Yin, X., Lorkiewicz, P. K., Wei, X., Feng, W., McClain, C., & Zhang, X. (2018). Simultaneous quantification of straight-chain and branched-chain short fatty acids by gas chromatography mass spectrometry. Journal of Chromatography B, Vol: 1092, pp: 359-367; DOI: 10.1016/j.jchromb.2018.06.028.

Hethershaw, E. L., Adamson, P. J., Smith, K. A., Goldsberry, W. N., Pease, R. J., Radford, S. E., Grant, P. J., Ariens, R., Maurer, M. C., & Philippou, H. (2018). The role of beta-barrels 1 and 2 i n the enzymatic activity of factor XIII A subunit. Journal of Thrombosis and Haemostasis, Vol: 16 (7), pp: 1391-1401; DOI: 10.1111/jth.14128.

Hona, R. K., Huq, A., & Ramezanipour, F. (2018). Electrical Properties of the Ordered Oxygen- Deficient Perovskite Ca2Fe0.5Ga1.5O5. Ionics, Vol, pp: 1-7.

Hona, R. K., Huq, A., & Ramezanipour, F. (2018). Magnetic Structure of CaSrFeCoO6–δ: Correlations with Structural Order. Materials Research Bulletin, Vol: 106, pp: 131-136; DOI: 10.1016/j.materresbull.2018.05.030.

Hona, R. K., & Ramezanipour, F. (2018). Disparity in Electrical and Magnetic Properties of Isostructural Oxygen-Deficient Perovskites BaSrCo2O6-δ and BaSrCoFeO6-δ. Journal of Materials Science: Materials in Electronics, Vol: 29, pp: 13464-13473; DOI: 10.1007/s10854-018-9471-8.

Hona, R. K., & Ramezanipour, F. (2018). Variation in Electrical Conductivity of A2Fe2O5 (A=Sr, Ba): The Role of Structural Order. Materials Research Express, Vol: 5 (7), pp: DOI: 10.1088/2053-1591/aad10e.

Jain, R., Mamun, A. A., Buchanan, R. M., Kozlowski, P. M., & Grapperhaus, C. A. (2018). Ligand-assisted metal-centered electrocatalytic hydrogen evolution upon reduction of a bis (thiosemicarbazonato) Ni (II) complex. . Inorg. Chem., Vol: 57 (21), pp: 13486–13493; DOI: 10.1021/acs.inorgchem.8b02110.

Kabra, A., Benson, C. A., & Li, Y. (2018). Backbone 1H, 13C, and 15N resonance assignments of deubiquitinase A in non-phosphorylated and phosphorylated forms. Biomolecular NMR Assignments, Vol, pp: 1-6.

Kharel, P. L., Cuillier, P. M., Fernando, K., Zamborini, F. P., & Alphenaar, B. A. (2018). Effect of Rare-Earth Metal Oxide Nanoparticles on the Conductivity of Nanocrystalline Titanium Dioxide: An Electrical and Electrochemical Approach. The Journal of Physical Chemistry C, Vol: 122 (27), pp: 15090–15096; DOI: 10.1021/acs.jpcc.8b02971.

FACULTY HIGHLIGHT

Dr. Farshid Ramezanipour joined the Department of Chemistry in 2015 as the first native of Iran to serve on our faculty. A Ph.D. graduate of McMaster University in Canada (2011), Farshid was a Postdoctoral Fellow at the University of Calgary (2011-2013) and a NSERC Postdoctoral Fellow at the University of California, Berkeley (2013-2015). Farshid’s research focuses on solid-state inorganic materials. Energy research is at the center of the current projects, which involve the synthesis and study of complex oxide materials for applications in batteries, fuel cells, electrocatalysis, and magnetism. A wide range of material synthesis and characterization techniques are utilized in these projects, such as diffraction, electron microscopy, photoelectron spectroscopy, magnetometry, electrochemical impedance, and electrocatalytic studies.

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Faculty 2018 Publications (continued)

Kharel, P. L., Zamborini, F. P., & Alphenaar, B. W. (2018). Enhancing the Photovoltaic Performance of Dye- Sensitized Solar Cells with Rare Earth Metal Oxide Nanoparticles. Journal of The Electrochemical Society, Vol: 165 (3), pp: H52-H65; DOI: 10.1149/2.1311802jes.

Landstrom, E. B., Handa, S., Aue, D. H., Gallou, F., & Lipshutz, B. H. (2018). EvanPhos. A New Ligand for ppm Pd-Catalyzed Suzuki-Miyaura Coupling in Either Organic Solvent or Water. Green Chemistry, Vol: 20 (15), pp: 3436-3443 DOI: 10.1039/C8GC01356J.

Lebiedzinska, A., Marszall, M. L., Grembecka, M., Czaja, J., Szefer, P., Kuta, J., Garabato, B. D., & Kozlowski, P. M. (2018). Detection of B6 Vitamers in Grain Products: Experimental and Computational Studies. Food Analytical Methods, Vol: 11 (3), pp: 725-732 DOI: 10.1007/s12161-017-1045-5; URL: https://doi.org/10.1007/s12161-017-1045-5

Li, B., Billur, R., Maurer, M. C., Kohler, H. P., Raddatz Mueller, P., Alberio, L., & Schroeder, V. (2018). Proline 36 of the Factor XIII Activation Peptide Plays a Crucial Role in Substrate Recognition and Zymogen Activation. Thrombosis and Haemostasis, Vol: 118 (12), pp: 2037-2045; DOI: 10.1055/s-0038-1675600.

Li, C., Li, Y., Ji, Z., Qiu, X., Lai, Y., Wei, J., Zhao, Y., Deng, L., Chen, Y., & Liu, J. (2018). Candidates for direct laser cooling of diatomic molecules with the 1Σ+−1Σ+ electronic transition system. Physical Review A, Vol: 97 (062501), pp: DOI: 10.1103/PhysRevA.97.062501.

*Li, M., Li, Q., Nantz, M., & Fu, X. (2018). Analysis of Carbonyl Compounds in Ambient Air by a Microreactor Approach. ACS Omega, Vol: 3 (6), pp: 6764–6769; DOI: 10.1021/acsomega.8b00503.

Liang, S., Hammond, G. B., & Xu, B. (2018). Metal-free, Regioselective Hydrochlorination of Unactivated Alkenes via a Combined Acid Catalytic System. RSC Green Chemistry, Vol: 20 (3), pp: 680-684 DOI: 10.1039/C7GC03665E.

Liu, J. (2018). Rotational and fine structure of open-shell molecules in nearly degenerate electronic states. Journal of Chemical Physics, Vol: 148 (12), pp: DOI: 10.1063/1.5021946.

Liu, S., Zeng, X., Xu, B., & Hammond, G. B. (2018). Mild Base Promoted Nucleophilic Substitution of Unactivated sp3-Carbon Electrophiles with Alkenylboronic Acids. Advanced Synthesis & Catalysis, Vol: 360 (19), pp: 3667-3671; DOI: 10.1002/adsc.201800826.

Lodowski, P., Toda, M. J., Ciura, K., Jaworska, M., & Kozlowski, P. M. (2018). Photolytic Properties of Antivitamins B12. Inorganic Chemistry, Vol: 57 (13), pp: 7838-7850; DOI: 10.1021/acs.inorgchem.8b00956.

Lu, Z., Jasinski, J. B., Handa, S., & Hammond, G. B. (2018). Recyclable Cellulose-Palladium Nanoparticles for Clean Cross-Coupling Chemistry. Organic & Biomolecular Chemistry, Vol: 16 (15), pp: 2748-2752; DOI: 10.1039/C8OB00527C.

*Mamun, A. A., Toda, M. J., Lodowski, P., Jaworska, M., & Kozlowski, P. M. (2018). Mechanism of Light Induced Radical Pair Formation in Coenzyme B12-Dependent Ethanolamine Ammonia-Lyase. ACS Catalysis, Vol: 8 (8), pp: 7164–7178; DOI: 10.1021/acscatal.8b00120.

FACULTY HIGHLIGHT

Professor Lee Thompson joined the Department in 2017, becoming the Department’s first ever British faculty member. Prior to his arrival in Louisville, he received his Ph.D. at Imperial College London in 2013 where he developed and applied computational methods for simulating the vibrational spectra of photoactive proteins. In 2014, he moved to the USA for a postdoctoral research position at the University of California, Merced (2014-2017) where he worked on approximate projection methods and their application to elucidate transition metal oxide cluster photodetachment spectra. Lee is a computational chemist whose research aims to develop quantum chemistry methodologies for understanding and developing materials for energy applications, including heterogeneous catalysts and photoactive materials. Simulation is vital for understanding properties and mechanisms for rational design of chemical systems. However, the properties that make for promising materials also render those systems difficult to study through simulation.

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Faculty 2018 Publications (continued)

Miller, N. A., Deb, A., Alonso-Mori, R., Glownia, J. M., Kiefer, L. M., Konar, A., Michocki, L. B., Sikorski, M., Sofferman, D. L., Song, S., Toda, M. J., Wiley, T. E., Zhu, D., Kozlowski, P. M., Kubarych, K. J., Penner-Hahn, J. E., & Sension, R. J. (2018). Ultrafast X-Ray Absorption Near Edge Structure Reveals Ballistic Excited State Structural Dynamics. Journal of Physical Chemistry A, Vol: 122 (22), pp: 4963–4971; DOI: 10.1021/acs.jpca.8b04223

Monsen, P. J., & Luzzio, F. A. (2018). Antiangiogenic Activity, Chemical Derivatization and Biophysical Properties of the Neurotoxic Acetogenin, Annonacin Isolated from Asimina triloba Fruit. Journal of Natural Products, Vol: 81 (8), pp: 1905-1909; DOI: 10.1021/acs.jnatprod.8b00284.

Mulmi, S., Hon a, R. K., Jasinski, J. B., & Ramezanipour, F. (2018). Electrical Conductivity of Sr2- xCaxFeMnO5 (x = 0, 1, 2). Journal of Solid State Electrochemistry, Vol: 22 (8), pp: 2329–2338; DOI: 10.1007/s10008-018-3947-6.

Patil, P. C., & Luzzio, F. A. (2018). Alternate Pathway for the Click Reaction of 2-(2- Azidophenyl)-4,5-diaryloxazoles. Tetrahedron Letters, Vol: 59 (38), pp: 3458-3460; DOI: https://doi.org/10.1016/j.tetlet.2018.07.062.

*Pattadar, D. K., & Zamborini, F. P. (2018). Size Stability Study of Catalytically Active Sub-2 nm Diameter Gold Nanoparticles Synthesized with Weak Stabilizers. Journal of American Chemical Society, Vol: 140 (43), pp: 14126−14133; DOI: 10.1021/jacs.8b06830.

Prodhan, A. I., Sleman, A. A., Kim, S., McClain, C. J., & Zhang, X. (2018). Generalization of reference system for calculating the second dimension retention index in GC×GC-MS. Journal of Analysis and Testing, Vol: 2 (3), pp: 263-273; DOI: 10.1007/s41664-018-0074-4.

Prodhan, A. I., Yin, X., Kim, S., McClain, C. J., & Zhang, X. (2018). Surface fitting for calculating the second dimension retention index in comprehensive two-dimensional gas chromatography mass spectrometry. Journal of Chromatography A, Vol: 1539, pp: 62-70; DOI: https://doi.org/10.1016/j.chroma.2018.01.049.

Saraei, N., Hietsoi, O., Mullins, C. S., Gupta, A. J., Frye, B. C., Mashuta, M. S., Buchanan, R. M., & Grapperhaus, C. A. (2018). Streams, cascades, and pools: various water cluster motifs in structurally similar Ni(II) complexes. CrystEngComm, Vol: 20 (44), pp: 7071-7081; DOI: 10.1039/C8CE01153B.

Sedgwick, D. M., & Hammond, G. B. (2018). The History and Future Challenges Associated with the Hydrogenation of Vinyl Fluorides. Journal of Fluorine Chemistry, Vol: 207, pp: 45-58; DOI: 10.1016/j.jfluchem.2017.12.019.

Sedgwick, D. M., López, I., Román, R., Kobayashi, N., Okoromoba, O. E., Xu, B., Hammond, G. B., Barrio, P., & Fustero, S. (2018). Metal-Free and User-Friendly Regioselective Hydroxyfluorination of Olefins. Organic Letters, Vol: 20 (8), pp: 2338 − 2341; DOI: 10.1021/acs.orglett.8b00681.

*Shao, T., Zhao, C., Li, F., Gu, Z., Liu, L., Zhang, L., Wang, Y., He, L., Liu, Y., Liu, Q., Chen, Y., Donde, H., Wang, R., Jala, R. J., Barve, S., Chen, S.-Y., Zhang, X., Chen, Y., McClain, C. J., & Feng, W. (2018). Intestinal HIF-1α deletion exacerbates alcoholic liver disease through inducing intestinal dysbiosis and barrier dysfunction. Journal of Hepatology, Vol: 69 (4), pp: 886-895; DOI: 10.1016/j.jhep.2018.05.021.

JOURNAL COVERS

Accumulation of hard work by Dr.

Craig Grapperhaus and Dr. Robert Buchanan research

groups

Accumulation of hard work by Dr.

Handa’s research group

Accumulation of hard work by Dr.

Handa’s research group

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Faculty 2018 Publications (continued)

Sharma, J. N., Pattadar, D. K., Mainali, B. P., & Zamborini, F. P. (2018). Size Determination of Metal Nanoparticles Based on Electrochemically Measured Surface-Area-to-Volume Ratios. Analytical Chemistry, Vol: 90 (15), pp: 9308-9314 DOI: 10.1021/acs.analchem.8b01905 .

*Shi, Z., Hammond, G. B., & Xu, B. (2018). Fast Chemical Reaction Work-Up Using Silicone Elastomer-Coated Glass Powders. ACS Omega, Vol: 3 (6), pp: 6748-6756; DOI: 10.1021/acsomega.8b00966.

Smith, D., Ansari, T. N., Andersson, M. P., Yadagiri, D., Ibrahim, F., Liang, S., Hammond, G. B., Gallou, F., & Handa, S. (2018). Micelle-enabled clean and selective sulfonylation of polyfluoroarenes in water under mild conditions. Green Chemistry, Vol: 20, pp: DOI: 10.1039/C7GC03514D.

Song, M., Li, X., Zhang, X., Shi, H., Vos, M., Wei, X., Wang, Y., Gao, H., Rouchka, E. C., Yin, X., Zhou, Z., Prough, R., Cave, M., & McClain, C. J. (2018). Dietary copper-fructose interactions alter gut microbial activity in male rats. American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol: 314 (1), pp: G119-G130; DOI: https://doi.org/10.1152/ajpgi.00378.2016.

Stivers, N., Islam, A., Reyes- Reyes, E., Casson, L., Aponte, J., Vaisberg, A., Hammond, G. B., & Bates, P. J. (2018). Plagiochiline A inhibits cytokinetic abscission and induces cell death. Molecules, Vol: 23 (6), pp: 1418-1427; DOI: 10.3390/molecules23061418.

Tan, J., Patil, P. C., Luzzio, F. A., & Demuth, D. R. (2018). In vitro and In vivo Activity of Peptidomimetic Compounds that Target the Periodontal Pathogen Porphyromonas gingivalis. Antimicrob. Agents. Chemother., Vol: 62 (7), pp: e00400-00418; DOI: 10.1128/AAC.00400-18.

Telfah, H., Reza, M. A., Alam, J., & Liu, J. (2018). Direct observation of tetrahydrofuranyl and tetrahydropyranyl peroxy radicals via cavity ring-down spectroscopy. Journal of Physical Chemistry Letters, Vol: 9 (16), pp: 4475-4480 DOI: 10.1021/acs.jpclett.8b01721.

Thompson, L. M. (2018). Global Elucidation of Broken Symmetry Solutions to the Independent Particle Model Through a Lie Algebraic Approach. Journal of Chemical Physics, Vol: 149 (19), pp: DOI: 10.1063/1.5049827.

Warner, D. R., Liu, H., Dastidar, S. G., Warner, J. B., Prodhan, A. I., Yin, X., Zhang, X., Feldstein, A. E., Gao, B., Prough, R. A., McClain, C. J., & Kirpich, I. A. (2018). Ethanol and unsaturated dietary fat induce unique patterns of hepatic ω-6 and ω-3 PUFA oxylipins in a mouse model of alcoholic liver disease PLOS ONE, Vol: 13 (9), pp: DOI: https://doi.org/10.1371/journal.pone.0204119.

Wiley, T. E., Miller, N. A., Miller, W. R., Sofferman, D., Lodowski, P., Toda, M. J., Jaworska, M., Kozlowski, P. M., & Sension, R. J. (2018). Off to the races: Comparison of excited state dynamics in vitamin B12 derivatives hydroxobobalmin and aquocobalamin. Journal of Physical Chemistry A, Vol: 122 (33), pp: 6693-6703 DOI: 10.1021/acs.jpca.8b06103.

Xie, Z., Raju, M. V. R., Stewart, A. C., Nantz, M. H., & X-A Fu. (2018). Imparting Sensitivity and Selectivity to a Gold Nanoparticle Chemiresistor Through Thiol Monolayer Functionalization for Sensing Acetone. RSC Advances, Vol: 8 (62), pp: 35618-35624 DOI: 10.1039/C8RA06137H.

Current Faculty

Division of Analytical Chemistry

Richard P. Baldwin M. Cecilia Yappert

Francis P. Zamborini Xiang Zhang

Division of Biochemistry

Muriel C. Maurer

Eugene G. Mueller Ying Li

Division of Physical Chemistry

Pawel M. Kozlowski

Ying Li Jinjun Liu

Lee Thompson Richard J. Wittebort

Division of Inorganic Chemistry

Robert M. Buchanan Craig A. Grapperhaus

Mark E. Noble Farshid Ramezanipour

Division of Organic Chemistry

Andrea Gorce

Gerald B. Hammond Sachin Handa

Frederick A. Luzzio Michael H. Nantz Christine V. Rich

Research Term Faculty

Danielle B. Franco

Andrea Gorce Lenore K. Hoyt Aleeta M. Powe Christine V. Rich

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Faculty 2018 Publications (continued)

Zeng, X., Li, J., Ng, C. K., Xu, B., & Hammond, G. B. (2018). (Radio)Fluoro-Click Reaction Enabled by a Hydrogen Bonding Cluster. Angew Chem Int Ed, Vol: 57 (11), pp: 2924–2928; DOI: 10.1002/anie.201711341.

*Zeng, X., Liu, S., Hammond, G. B., & Xu, B. (2018). Hydrogen Bonding Assisted Brønsted Acid and Gold Catalysis: Access to both E- and Z- 1,2- Haloalkenes via Hydrochlorination of Haloalkynes. ACS Catal., Vol: 8 (2), pp: 904 − 909; DOI: 10.1021/acscatal.7b03563.

Zhao, F. C., Y.; Gao, L.; Qin, X.; Du, G.; Zhang, X.; Zhou, Y. (2018). Protective effects of Scutellaria baicalensis Georgi extract on D-galactose induced aging rats. Metabolic Brain Disease, Vol: 33 (9), pp: 1401-1412; DOI: https://doi.org/10.1007/s11011-018-0229-z.

In Memoriam

(Chemistry faculty who passed away in 2018) Tom Crawford and Gradus Shoemaker

While it’s great to share news about new young faculty who have joined the Chemistry family, we also want to let you know about the recent loss of two colleagues of long standing. Unfortunately, 2018 saw the passing of Professor Thomas Crawford in November and Professor Gradus Shoemaker in December – both of whose careers included decades-long contributions to the Chemistry Department, the University of Louisville, and thousands of students who passed through. After receiving his Ph.D. at the University of Illinois, Grad Shoemaker joined U of L in 1949 and, for close to forty years, taught organic chemistry and biochemistry (back when it was part of the University’s home economics program!). Many alums will remember him as the Grand Marshal of their Commencement ceremony. Tom Crawford was a Louisville native who earned his B.S. and Ph.D. here at U of L. He joined the Chemistry faculty in 1961 and continued until his retirement in 1998. Despite extensive administrative service, Tom’s first love was teaching; and he always found it important to stay in the classroom. Also, as witnessed by the 100,000 or so who experienced his traveling “chemical magic” show, he clearly had the best singing voice on our faculty. Both Gradus and Tom made enormous contributions and will be missed. Both were excellent teachers and great colleagues but, more important, were true gentlemen.

Faculty 2018 Honors & Awards Dr. Jinjun Liu received the Gordon and Betty Moore Foundation Visitor Award from the Fundamental Physics Innovation Awards Project of the American Physical Society (APS)

Dr. G.B. Hammond received the Dr. José Tola Pasquel Professorship, given by the Pontificia Universidad Católica del Perú

Dr. Sachin Handa received the 2018 Ralph E. Powe Junior Faculty Enhancement Award and the ACS Green Chemistry Peter J. Dunn Award

Dr. Muriel Maurer received the Councillor for the International Fibrinogen Research Society

Dr. Michael Nantz received the Distinguished University Scholar Award

Faculty 2018 External Funding Awarded Robert Buchanan: ($474,475 NSF)

Dr. Craig Grapperhaus: ($150,000 from NSF)

Dr. Sachin Handa: ($50,000 from Kentucky Science & Engineering Foundation, $105,000 from Novartis Pharmaceuticals Corp., & $10,000 from Oak Ridge Associated Universities)

Dr. G.B. Hammond: ($59,703 and $292,600 from NIH)

Dr. Pawel Kozlowski: ($15,000 from NSF)

Dr. Ying Li: ($454,829 from NIH)

Dr. Michael Nantz: ($1,335,021 from Superfund Research Program, Co-PI $601,951 PI Xiao-An Fu, Chemical Engineering, and $48,654 from Breath Diagnostics, Inc.)

Dr. Farshid Ramezanipour: ($10,000 from UofL)

Dr. Lee Thompson: ($110,000 from American Chemical Society Petroleum Research Fund)

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Students 2018 George R. Pack Award

Dr. Kelly Mouapi-Davis Thesis Title: Characterizing Reactive Glutamines in Fibrinogen and Elucidating Factor XIII Substrate Specificity Dr. Kelly Mouapi-Davis received her BA in Chemistry (cum laude) with a minor in Spanish from Berea College in 2012, and obtained her Ph.D. in Chemistry from the University of Louisville in 2017 under the mentorship of Dr. Muriel Maurer. For her dissertation, she used mass spectrometry and NMR spectroscopy to elucidate the mechanisms utilized by two important proteins, Fibrinogen and Factor XIII, involved in the formation of stable blood clots. Dr. Mouapi is currently a NIH T32 Research Fellow at the Smidt Heart Institute, Cedars-Sinai Medical Center in Los Angeles, CA. At the Advanced Clinical BioSystems Institute, Dr. Mouapi designs and applies targeted mass spectrometry-based assays that combine proteomics and lipidomics for early prediction of major adverse cardiac events. She has

presented her research at several national and international conferences and was awarded a Young Investigator award at the International Fibrinogen Workshop (2014). Her current work on remote microsampling was recently selected for a talk at the International Human Proteome Organization on targeting Women’s Health. Dr. Mouapi has authored and co-authored several peer-reviewed publications. She loves to travel, volunteer locally to promote healthy lifestyles, inspire young minds to pursue STEM-related fields, and share tips and resources for success with the next generation of scientists. Past Award Recipients 2017 Andrew Haddad, PhD – mentored by Craig A. Grapperhaus, PhD Thesis Title: Homogeneous Ligand-Centered Hydrogen Evolution and Hydrogen Oxidation: Exploiting Redox

Non-Innocence to Drive Catalysis Shengzong Liang, PhD – mentored by G.B. Hammond, PhD Thesis Title: Development of Recyclable Gold Nanoparticles for Routine Benchtop Catalysis in Organic

Transformations 2016 Rafael Masitas, PhD – mentored by Francis Zamborini, PhD Thesis Title: The Unique Electrochemical Reactivity of Small Metal Nanoparticles 2015 Ralph Knipp, PhD — mentored by Michael H. Nantz, PhD Thesis title: Triggered Release of Small Molecules from Solid Supports Using Heat or an Applied Magnetic Field 2014 Deepika Malhotra, PhD — mentored by G. B. Hammond, PhD Thesis title: Expanding the Frontier of Gold Catalyzed Cyclizations and Rational Ligand Design

2018 Chemistry Honors & Awards

Special Citations for Outstanding Academic Performance: 3.5 or better in chemistry • Seth Blankenship • Kyle Castaneda • Peyton Davis • Alyssa Dues • Zofia Hetman

• John Hinely • Brenna Kaelin • Sean Noble • Gabby Oropilla • Shane Reeves

• Troy Sterling • Andrew Stewart • Pratik Thapa • Dunia Zedan

Recipients of the ACS-certified degree Alyssa Dues Zofia Hetman

ACS Inorganic Chemistry Award Zofia Hetman

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ACS Analytical Chemistry Division Award Sam Van Buskirk American Institute of Chemists Award Chemistry - Zofia Hetman Biochemistry - Kyle Castaneda Undergraduate Teaching Assistant Award Gabby Oropilla Marcus Rommelman

The Royal Society of Chemistry Certificate of Excellence Troy Sterling The Chemistry Faculty Award for Excellence Brenna Kaelin The ACS Outstanding Graduate in Chemistry Kyle Castaneda

Student Accolades Bhavana Pavuluri (from Dr. Handa’s Group) —"Ciba Travel Award" from ACS

2018 Graduates Doctoral Students Boris Anokhin, M.S. (Advisor: Dr. Muriel Maurer) Dissertation Title: Coagulation Factor XIII A: Biochemical Properties Underlying Physiological Function Dr. Ramya Billur (Advisor: Dr. Muriel Maurer) Dissertation Title: Biophysical Exploration of Conformational Environments in Zymogen Prothrombin and Blood Coagulant Thrombin Rene Ebule (Advisor: Dr. Gerald B. Hammond) Dissertation Title: Investigating the Unique Reactivity of Novel HX (X=Cl, Br) Reagents with Alkenes and Alkynes Dr. Brady Garabato (Advisor: Dr. Pawel Kozlowski) Dissertation Title: Computational Modeling of Electronically Excited States in Cobalamin-Dependent Reactions Dr. Zhichao Lu (Advisor: Dr. Gerald B. Hammond) Dissertation Title: Long-Range Electrostatic Interactions in Gold Catalysis and Fluorinating Reagent Development Abigail Schnepf, M.S. (Advisor: Dr. M. Cecilia Yappert) Dissertation Title: The Regional Distribution and Molecular Interactions Phospholipids and Glucose in Mammalian Vitreous Humors Master Students Stacy Allen, M.S.

(Advisor: Dr. Francis P. Zamborini) Boris Anokhin, M.S.

(Advisor: Dr. Muriel Maurer) Caleb A. Calvary, M.S.

(Advisor: Dr. Craig Grapperhaus) Ma Faye Charmagne Aquino A. Carvajal, M.S.

(Advisor: Dr. Richard Wittebort) Md Emtias Chowdhury, M.S.

(Advisor: Dr. Craig Grapperhaus) Rene Ebule, M.S.

(Advisor: Dr. Gerald B. Hammond) Austin Gibbs, M.S.

(Advisor: Dr. Eugene Mueller) Ram K. Hona, M.S.

(Advisor: Dr. Farshid Ramezanipour) Nour M. Jamhawi, M.S.

(Advisor: Dr. Richard Wittebort) Abdelqader M. Jamhawi, M.S.

(Advisor: Dr. Jinjun Liu)

Abdullah Al Mamun, M.S. (Advisor: Dr. Pawel Kozlowski)

Dhruba K. Pattadar, M.S. (Advisor: Dr. Francis P. Zamborini)

Anam C. Paul, M.S. (Advisor: Dr. Jinjun Liu)

Md Aminul Islam Prodhan, M.S. (Advisor: Dr. Xang)

Md Asmaul Reza, M.S. (Advisor: Dr. Jinjun Liu)

Jarrid M. Ronnebaum, M.S. (Advisor: Dr. Fredrick Luzzio)

Abigail Schnepf, M.S. (Advisor: Dr. M. Cecilia Yappert)

Jay Narayan Sharma, M.S. (Advisor: Dr. Francis P. Zamborini)

Jacob M. Strain, M.S. (Advisor: Dr. Francis P. Zamborini)

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Undergraduate Students Maryssa L. Becker Hailee D. Bowling Rachel A. Carter Peyton D. Davis Adam P. Holstein-Seibert Gabrielle B. Oropilla Samuel F. Van Buskirk Omair Ahmed

Charles K. Castaneda Victoria R. Das Alyssa E. Dues Zofia A. Hetman John C. Hinely Brenna R. Kaelin Konnor Q. Long Sean E. Noble

Shane A. Reeves Marcus A. Rommelman Cara R. Schwartz Troy E. Sterling Andrew C. Stewart Pratik Thapa

Department Overview

Belknap Academic Building (BAB) In August 2018, the new Belknap Academic Building (BAB) opened for business. Located on the site of the old Crawford Gymnasium, the BAB is an $80 million state-of-the-art structure entirely devoted to undergraduate instruction. In addition to 17 very high-tech classrooms, the structure also houses state-of-the-art labs for introductory chemistry, biology, and physics courses. With the 6 new laboratories for our general chemistry labs in the BAB, we now were able to offer Chemistry labs to nearly 1700 first-year students last fall. It’s a spectacular addition to the south end of the Belknap campus and was sorely needed to help meet the academic needs of our rapidly growing STEM enrollment. We would be happy to give you a tour some time!

Belknap Academic Building (BAB) BAB Atrium

A High Tech Teaching Classroom One of six CHEM Labs in the BAB

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Chemistry Building Room 114 Thanks to the generous donations from Tilford F. Riehl and Helen Lang, the Department of Chemistry is able to renovate one of its teaching labs into an Organic Chemistry Lab. The new lab is on schedule to be ready in time for fall 2019 Classes.

Call for News We would love to hear from our alumni. Please send us your latest news –personal and family accomplishments, professional honors, committees upon which you serve, offices to which you have been elected, job changes you have made, papers you have presented or published, etc. Future newsletters may be distributed electronically. Please send your email address to the Department of Chemistry at deptchem@louisville.edu.

Contact Us Department of Chemistry

University of Louisville 2320 South Brooks Street

Louisville, KY 40292

Phone: 502-852-6798 Fax: 502-852-8149

Email: deptchem@louisville.edu Website: http://louisville.edu/chemistry

Find us at:

UofL Department of Chemistry