department of heaxin human servicesviral oncogenesis and pathogenesis of hepatocellular carcinoma...
TRANSCRIPT
NOTICE OF MAILING CHANGE 0 Check here ifyou nish t o
discontinue receiving this publication
0Check here if your address has changed and you wish to continue receiving this publication. Make corrections below and mail this page to:
NIH Guide Printing & Reproduction Branch National Institutes of Health Room B4BN08, Building 31 Bethesda, Maryland 20892
First Class Mail Postages & Fees Paid
PHS/NIH/OD
US. DEPARTMENT OF HEAXIN AND HUMAN SERVICES
OFFICIAL BCWNESS Penalty for Private Use,$300
The NIH Guide announces scientific initiativesand pmldes policy and administrative information to individuals and organizationswho need to be kept informed o f opportunities. requirementc.and changes in extra-mural prwams administered by the National Instituteso f Health. Vol. 19, No. 2 January 12, 1990
Vol. 19, No. 2, January 12, 1990
AIDS COMMUNITY-BASED OUTREACH/INTERVENTION RESEARCH PROGRAM(RFA DA-90-02) .............................................................. National Institute on Drug Abuse Index: DRUG ABUSE
1 I,
VIRAL ONCOGENESIS AND PATHOGENESIS OF HEPATOCELLULAR CARCINOMA (RFA 90-CA-08) .............................................................. National Cancer Institute
2
Index: CANCER
MOLECULAR APPROACHES TO DRUG ABUSE RESEARCH ................................. 4 National Institute on Drug Abuse Index: DRUG ABUSE
ERRATA
NCI/MARC SUMMER TRAINING SUPPLEMENT (PA) .................................... 6 National Cancer Institute Indext CANCER
INVESTIGATIONS INTO METHODS THAT REPLACE OR REDUCE VERTEBRATE ANIMALS USED IN RESEARCH, OR LESSEN THEIR PAIN AND DISTRESS (PA) .................... 6 National Institutes of Health Alcohol, Drug Abuse, and Mental Health Administration Index: NATIONAL INSTITUTES OF HEALTH
ALCOHOL, DRUG ABUSE, AND MENTAL HEALTH ADMINISTRATION
DATED ANNOUNCEMENTS IRFPs AND RFAs)
AIDS COMMUNITY-BASED OUTREACH/INTERVENTION RESEARCH PROGM
RFA AVAILABLE: DA-90-024
P.T. 34, FF; K.W. 0715008, 0403004, 0404021, 0411005
National I n s t i t u t e on Drug Abuse
APPLICATION RECEIPT DATECS)
Receipt I n i t i a l Advisory Council Earliest Date Review Date S t a r t Date
March 123C JuneyJuly Sept/Oct November
A f t e r t h i s s p e c i a l r e c e i p t d a t e , a p p l i c a t i o n s may be submitted t o t h i s announcement us ing t h e r e g u l a r AIDS r e c e i p t d a t e s .
PURPOSE
The purpose o f t h i s r e s e a r c h g r a n t program is t o announce a coope ra t ive agreement program t o e v a l u a t e t h e e f f i c a c y of community-based i n t e r v e n t i o n s t r a t e g i e s designed t o prevent and reduce t h e spread of AIDS among intravenous ( I V ) drug u s e r s , t h e i r s exua l p a r t n e r s , and t h o s e a t demonstrable r isk f o r intravenous drug use .
RESEARCH OBJECTIVES
Emphasis is p laced on ga in ing an understanding of t h e e f f i c a c y o f d i f f e r e n t i nnova t ive s t r a t e g i e s f o r con ta in ing t h e spread o f AIDS wi th in and from h i g h - r i s k populat ions, e . g . , I V drug u s e r s who are no t i n t r ea tmen t , t h e i r s exua l p a r t n e r s , and t h o s e a t demonstratable r i s k f o r intravenous drug use. There is a l s o a l a r g e concern with monitoring and understanding t h e n a t u r e of r i s k - t a k i n g behavior w i th in communities and groups over t i m e . Consequently,t h e Nat ional I n s t i t u t e on Drug Abuse ( N I D A ) w i l l cont inue t o fac i l i t a te g r a n t e e c o l l a b o r a t i o n and w i l l make a closed-ended in t e rv i ew schedule , t h e AIDS I n i t i a l Assessment, t o be adminis tered t o a l l s u b j e c t s admit ted i n t o t h e
4 a p p l i c a n t ’ s s tudy . Th i s instrument is t o be adminis tered as a b a s e l i n e measure p r i o r t o H I V t e s t i n g and/or t h e i n i t i a t i o n of t r a d i t i o n a l o r innovat ive i n t e r v e n t i o n s . The a p p l i c a n t w i l l a l s o s t a t e hypotheses s /he w i l l be t e s t i n g i n t h e cour se o f t h e s tudy . It is expected t h a t outcome v a r i a b l e s w i l l c o n s i s t o f a t least t h e fol lowing: ( a ) r educ t ion i n r i s k - t a k i n gbehaviors a s s o c i a t e d with needle use and with sexua l behaviors ; ( b ) i n c r e a s e s i n knowledge about AIDS t r ansmiss ion and r i s k f a c t o r s . Beyond t h e outcome study and t h e desc r ip t ion /mon i to r ing of r i s k - t a k i n g behaviors and knowledgeregarding AIDS t r ansmiss ion , t h e a p p l i c a n t should p l a n f o r t h e conduct of sub-studies r e l e v a n t t o an understanding o f t h e i s s u e s involved i n planningand developing AIDS preven t ion programs f o r t h e d i f f e r e n t popu la t ions t h e y are studying.
INCLUSION OF MINORITIES I N STUDY POPULATIONS
The Alcohol, Drug Abuse, and Mental Health Adminis t ra t ion (ADAMHA) urgesa p p l i c a n t s t o g ive added a t t e n t i o n (where f e a s i b l e and a p p r o p r i a t e ) t o t h e i n c l u s i o n of m i n o r i t i e s i n s tudy popu la t ions f o r r e sea rch i n t o t h e e t i o l o g y of d i s e a s e s , r e s e a r c h i n behav io ra l and s o c i a l s c i ences , c l i n i c a l s t u d i e s o f t r ea tmen t and t r ea tmen t outcomes, r e sea rch on t h e dynamics of h e a l t h care and its impact on d i s e a s e , and a p p r o p r i a t e i n t e r v e n t i o n s f o r d i s e a s e prevent ionand h e a l t h promotion. If m i n o r i t i e s are no t included i n a given s tudy, a c l e a r r a t i o n a l e f o r t h e i r exc lus ion should be provided.
INCLUSION OF WOMEN I N STUDY POPULATIONS
ADAMHA u rges a p p l i c a n t s t o cons ide r t h e i n c l u s i o n o f women i n t h e s tudypopu la t ions f o r a l l c l i n i c a l r e sea rch e f f o r t s . Exceptions would be s t u d i e s o f d i s e a s e s which e x c l u s i v e l y a f f e c t males o r where involvement of pregnant women may expose t h e f e t u s t o undue r i s k s . Gender d i f f e r e n c e s should be noted and eva lua ted . If women are no t t o be included, a clear r a t i o n a l e should be provided f o r t h e i r exc lus ion .
I n o rde r t o provide more p r e c i s e information t o t h e treatment community, it is ‘1.1 recommended t h a t p u b l i c a t i o n s r e s u l t i n g from ADAMHA-supported r e sea rch i n
which t h e s tudy popu la t ion was l i m i t e d t o one sex f o r any reason o t h e r t h a n t h a t t h e d i s e a s e o r cond i t ion s t u d i e d e x c l u s i v e l y affects t h a t sex, should
Vol. 19, No. 2, January 12, 1990 - Page 1
s ta te , i n t h e a b s t r a c t summary, t h e gender o f t h e popula t ion s tud ied , e . g . ,"male p a t i e n t s r f f "male volunteers , " "female p a t i e n t s , " "female vo lun tee r s . "
AVAILABILITY OF FUNDS
It is es t imated t h a t i n N 1990, up t o 20 p r o j e c t s may be funded under t h i s announcement. Appl ica t ions rece ived i n response t o t h i s announcement w i l l compete f o r approximately $7 m i l l i o n i n FY 1990 g r a n t money expected t o be a v a i l a b l e f o r t h i s purpose.
REVIEW PROCEDURES
Appl ica t ions rece ived under t h i s announcement w i l l be ass igned t o an i n i t i a l reveiw group f o r s c i e n t i f i c and t e c h n i c a l merit review. Such groups c o n s i s t p r i m a r i l y o f non-Federal e x p e r t s . N o t i f i c a t i o n o f review outcome w i l l be s e n t t o t h e a p p l i c a n t as soon as it is a v a i l a b l e . Appl ica t ions w i l l r e ce ive a secondary review by t h e Nat ional Advisory Council o f t h e Nat ional I n s t i t u t e on Drug Abuse whose review may be based on p o l i c y cons ide ra t ions as w e l l as s c i e n t i f i c m e r i t . Only a p p l i c a n t s recommended f o r approval by t h e Nat iona l Advisory Council w i l l be considered f o r funding.
APPLICATION PROCEDURES
Appl icants must use t h e s tandard PHS-398 (Rev. 10/88) r e sea rch g r a n ta p p l i c a t i o n form. "AIDS Community-based Research Program" should be typed on Item #2 on t h e face page of t h e PHS 398 form and check t h e YES box. Appl ica t ion k i t s conta in ing t h e necessary forma and i n s t r u c t i o n s may be obta ined from t h e fo l lowing o f f i c e :
Grants Management Branch Nat iona l I n s t i t u t e on Drug Abuse 5600 F i s h e r s Lane, Room 8-A-54 Rockvi l le , Maryland 20857 Telephone: (301) 443-6710
INQUIRIES
Fur ther information and c o n s u l t a t i o n on program requirements can be obta ined from:
Chief , Community Research Branch Nat ional I n s t i t u t e on Drug Abuse 5600 F i s h e r s Lane, Room 9-A-30 Rockvi l le , Maryland 20857 Telephone: (301) 443-6720
VIRAL ONCOGENESIS AND PATHOGENESIS OF HEPATOCELLULAR CARCINOMA
RFA AVAILABLE: 90-CA-08
POT. 34; K.W. 0715035, 0705025, 0765033, 1002045
Nat ional Cancer I n s t i t u t e
Letter o f I n t e n t R e c e i p t Date: June 4, 1990 Appl ica t ion Receipt Date: August 3? 1990
INTRODUCTION
A d i v e r s e group of v i r a l agen t s are e t i o l o g i c a l l y a s s o c i a t e d with human v i r a l h e p a t i t i s , some o f which are a l s o a s soc ia t ed wi th chronic sequelae t h a t may p rogres s t o primary h e p a t o c e l l u l a r carcinoma (PHC). H e p a t i t i s B v i r u s (HBV)is a double-stranded DNA v i r u s t h a t occurs worldwide and can be t r a n s m i t t e d bycontaminated blood, blood products , or u n s t e r i l e needles . I n add i t ion ,h o r i z o n t a l spread o f t h e v i r u s occurs , p a r t i c u l a r l y among young ch i ld ren , bycontamination o f mucous membranes or small breaks i n t h e s k i n wi th contaminated s e c r e t i o n s from i n f e c t e d playmates. P e r i n a t a l ( v e r t i c a l )t ransmiss ion from HBV-infected mothers t o o f f s p r i n g also occurs and is a p a r t i c u l a r l y important mode o f t ransmiss ion i n A s i a . HBV p rogres ses t o a chronic i n f e c t i o n or chronic carrier s t a t e i n 5-'IO percent o f t h e a d u l t c l i n i c a l cases and has been s t r o n g l y a s s o c i a t e d wi th t h e e t i o l o g y o f PHC.
The t e r m "non-A, non-B h e p a t i t i s v i rus" (NANBH) d e s c r i b e s v i r a l h e p a t i t i s t h a t occurs i n t h e absence o f s e r o l o g i c markers f o r known hepa to t rop ic agen t s such Ir
as h e p a t i t i s A v i r u s (HAV), HBV, o r o t h e r v i r u s e s such as cytomegalovirus or Epstein-Barr v i r u s t h a t are a s soc ia t ed with h e p a t i t i s - l i k e symptoms. Three epidemiologic forms o f human NANBH, c a l l e d "blood-transmitted",
Vol. 19, No. 2, January 12, 1990 - Page 2
wcoagulation-factor-transmitted", and " e n t e r i c " o r "waterborne", have been proposed based on s t u d i e s i n primate models. NANBH agen t s cause an a c u t e h e p a t i t i s t h a t is somewhat milder t h a n HBV induced d i sease ; however, it h a s been est imated t h a t a t l eas t h a l f of t h e NANBH i n f e c t i o n s r e s u l t i n ch ron ic h e p a t i t i s , which i n t u r n r e s u l t s i n c i r r h o s i s i n approximately 20 percent o f t h e s e cases. Chron ic i ty and c i r r h o s i s c a r r y increased r i s k o f PHC. NANBH is of p a r t i c u l a r s i g n i f i c a n c e i n t h e U.S. s i n c e up t o 10 percen t of t r a n s f u s i o n s
j i n t h e U.S. are thought t o r e s u l t i n h e p a t i t i s and more t h a n 90 percen t of the t r ans fus ion -as soc ia t ed h e p a t i t i s i n t h e U.S. is a s s o c i a t e d with NANB agen t s .The "blood t r a n s m i t t e d " form of NANBH, a l s o r e f e r r e d t o by some i n v e s t i g a t o r s as h e p a t i t i s C v i r u s (HCV) , has an RNA genome and is t h e only one of t h e s e agen t s c u r r e n t l y a s s o c i a t e d wi th primary h e p a t o c e l l u l a r carcinoma.
This Request f o r App l i ca t ions (RFA) is f o r a s i n g l e competi t ion with a dead l ine o f August 3, 1990, f o r r e c e i p t of a p p l i c a t i o n s , and June 4, 1990, f o r receipt of l e t t e r s o f i n t e n t . Applicat ions should be prepared and submitted i n accordance with t h e a i m s and requirements descr ibed i n t h e complete RFA document which may be ob ta ined from t h e program d i r e c t o r l i s t e d i n t h e INQUIRIES s e c t i o n .
RESEARCH GOALS AND SCOPE
The o v e r a l l t h r u s t o f t h i s RFA is t o s t i m u l a t e r e sea rch on t h e human h e p a t i t i sv i r u s e s a s s o c i a t e d with l i v e r cancer ( e . g . HBV, NANBH or HCV), and t h e i r i n t e r a c t i o n s with environmental f a c t o r s I:e.g., d i e t a r y a f l a t o x i n ) , and h o s t f a c t o r s (chromosomal f r a g i l i t y , immune response) i n o rde r t o i d e n t i f y t h e mechanism(s1 involved i n es tabl ishment o f c h r o n i c i t y , c e l l t r ans fo rma t ion , and PHC. Examples o f r e s e a r c h o b j e c t i v e s would inc lude t h e fol lowing: (i)development and/or u se of s e n s i t i v e and s p e c i f i c a s says f o r blood-borne NANBH (HCV) t o determine t h e p o s s i b l e r o l e o f t h i s agent i n PHC; (ii)de te rmina t ion o f t h e prevalence o f HBV s t r a i n s r e s i s t a n t t o c u r r e n t l y a v a i l a b l e vaccines and t h e r o l e of g e n e t i c v a r i a t i o n o f HBV i s o l a t e s i n t h i s process; (iii)d e f i n i t i o n o f t h e r o l e o f t h e HBV X gene i n t r ans fo rma t ion ; ( i v ) sys t ema t i cs t u d i e s o f co-carcinogenesis ( v i r a l , chemical, and/or d i e t a r y f a c t o r s ) i n t h e development o f PHC i n animal models of human cancer (e .g . t h e woodchuck); ( V Ideterminat ion, i n t r a n s g e n i c animals, of t h e oncogenic p o t e n t i a l of specif icv i r a l gene products ; ( v i ) determinat ion of t h e p o s s i b l e r o l e of c e l l u l a r oncogenes or anti-oncogenes i n PHC; ( v i i ) i n v e s t i g a t i o n o f t h e r o l e o f chromosomal abnorma l i t i e s i n s u s c e p t i b i l i t y t o PHC; and ( v i i i ) measurement of t h e h o s t response t o i n d i v i d u a l v i r a l p r o t e i n s with t h e goal of d e l i n e a t i n gt h e hos t response t o d i f f e r e n t v i r a l a n t i g e n s i n h e p a t i t i s - a s s o c i a t e dpre-malignant and malignant s eque lae .
Where appropr i a t e , c o l l a b o r a t i v e arrangements t o f ac i l i t a t e t h e achievement of r e s e a r c h g o a l s should be considered.
App l i ca t ions should c o n t a i n as g o a l s both methodological development and a p p l i c a t i o n t o a s p e c i f i c area of HBV or HCV oncogenesis as w e l l as s t u d i e s o f p o s s i b l e s y n e r g i s t i c i n t e r a c t i o n s between v i r u s e s , a l coho l , a f l a t o x i n s , etc. ;b a s i c and/or c l i n i c a l i s s u e s are considered as a p p r o p r i a t e s u b j e c t s f o r t h i s RFA . MECHANISM OF SUPPORT
This RFA w i l l u se t h e Nat ional I n s t i t u t e s of Health ( N I H ) grant- in-aid ( R o l l .R e s p o n s i b i l i t y f o r t h e planning, d i r e c t i o n and execut ion o f t h e proposedp r o j e c t w i l l be s o l e l y t h a t of t h e a p p l i c a n t . Except as s t a t e d i n t h i s RFA,awards w i l l be adminis tered under PHS g r a n t s p o l i c y as desc r ibed i n t h e Pub l i c Heal th Se rv ice Grants Po l i cy Statement, DHHS P u b l i c a t i o n No. (OASH) 82-50,000,r e v i s e d January 1, 1987.
T h i s RFA is a one-time s o l i c i t a t i o n . Generally, f u t u r e u n s o l i c i t e d competingrenewal a p p l i c a t i o n s w i l l compete as r e sea rch p r o j e c t a p p l i c a t i o n s with a l l o t h e r i n v e s t i g a t o r - i n i t i a t e d a p p l i c a t i o n s and be reviewed i n a s t and ingDiv i s ion of Research Grants s tudy s e c t i o n . However, should t h e Nat ional Cancer I n s t i t u t e ( N C I ) determine t h a t t h e r e is a s u f f i c i e n t cont inuing programneed, N C I may announce a r eques t f o r renewal a p p l i c a t i o n s .
Approximately Sl,000,000 i n t o t a l c o s t s p e r yea r f o r f i v e (5) y e a r s w i l l be committed t o fund a p p l i c a t i o n s t h a t a r e submitted i n response t o t h i s RFA. Actual funding is dependent on t h e r e c e i p t o f a s u f f i c i e n t number o f a p p l i c a t i o n s of h igh s c i e n t i f i c merit. The t o t a l p r o j e c t pe r iod f o r a p p l i c a t i o n s submitted i n response t o t h e p re sen t RFA should no t exceed f i v e (5) y e a r s . The ear l ies t f e a s i b l e start: d a t e f o r t h e i n i t i a l awards w i l l be A p r i l 1, 1991. Although t h i s program is provided f o r i n t h e f i n a n c i a l p l a n sof t h e N C I , award o f g r a n t s pursuant t o t h i s RFA is a l s o con t ingen t upon t h e a v a i l a b i l i t y o f funds f o r t h i s purpose, Non-profit and f o r - p r o f i t
Vol. 19, No. 2, January 12, 1990 - Page 3
i n s t i t u t i o n s are e l i g i b l e t o apply, as are both f o r e i g n and domestic i n s t i t u t i o n s .
INQUIRIES
A copy of t h e complete RFA desc r ib ing t h e r e sea rch g o a l s and scope, t h e review cr i te r ia , and t h e method of applying can be obtained by con tac t ing :
D r . John S . Cole, I11 Program Di rec to r RNA Virus S t u d i e s I1 Bio log ica l Carcinogenesis Branch Divis ion o f Cancer Et io logy Nat iona l Cancer I n s t i t u t e Execut ive Plaza North, Room 540 Bethesda, Maryland 20892 Telephone: ( 3 0 1 ) 496-1718
Writ ten or t e lephone i n q u i r i e s concerning t h e o b j e c t i v e s and scope o f t h i s RFA or i n q u i r i e s about whether or n o t s p e c i f i c proposed r e sea rch would be respons ive are encouraged and should be d i r e c t e d t o D r , Cole a t t h e above address . The program d i r e c t o r welcomes t h e oppor tuni ty t o c l a r i f y any i s s u e s or ques t ions from p o t e n t i a l a p p l i c a n t s .
ONGOING PROGRAM ANNOUNCEMENTS
MOLECULAR APPROACHES TO DRUG ABUSE RESEARCY
P.T. 34; K.W. 0404009, 1002008, 0760075, 0765010
Nat iona l I n s t i t u t e on Drug Abuse
PURPOSE
The purpose o f t h i s announcement i s t o s t i m u l a t e b a s i c r e sea rch i n t h e molecular b io logy of t h e a d d i c t i v e process . I n genera l , r e sea rch is needed t o : ( 1 ) i d e n t i f y and e l u c i d a t e t h e s t r u c t u r e of c e l l u l a r membrane componentssuch as r e c e p t o r s and t r a n s p o r t e r s with specif ic a f f i n i t y f o r drugs of abuse;(2) e s t a b l i s h t h e b i o s y n t h e t i c pathways by which i n t e r - and i n t r a - c e l l u l a r messengers involved i n t h e a d d i c t i v e process a r e synthes ized , modified and degraded; (3) explore t h e molecular mechanism(s1 involved i n to l e rance ,dependence, c r av ing and o t h e r man i fe s t a t ions o f t h e a d d i c t i v e process; and (4)develop new methods and resources t o f a c i l i t a t e t h e s tudy o f t h e a d d i c t i v e process a t t h e molecular l e v e l .
RESEARCH OBJECTIVESX
The Nat iona l I n s t i t u t e on Drug Abuse ( N I D A ) encourages t h e submission o f r e sea rch proposa ls t o ga the r and i n t e g r a t e information a t t h e molecular biology and g e n e t i c l e v e l s i n order t o understand t h e under ly ing b a s i s o f add ic t ion , t h e consequences o f long-term drug abuse, and t o gene ra t e b e t t e r strategies f o r e f f e c t i v e d iagnos is , t rea tment , educa t ion and prevent ion .
Examples o f p a r t i c u l a r i n t e r e s t inc lude t h e foll.owing:
1 . Neuropeptides: S t u d i e s o f t h e express ion , process ing and d i s t r i b u t i o n of v a r i o u s r e l e v a n t neuropept ide genes a t d i f f e ren t : developmental stages.
2. Receptors: E f f o r t s t o s tudy t h e cloned genes o f r ecep to r s , ion channels and t r a n s p o r t e r s i n terms of genomic organiza t ion , chromosomal l o c a l i z a t i o n as w e l l as t h e r e g u l a t i o n o f t h e i r express ion .
3. Genet ic Fac to r s o f t h e Addict ion Processes: Development o f s t r a i n s o f animals e x h i b i t i n g v a r i a t i o n i n drug preference , v u l n e r a b i l i t y , t o l e r a n c e and dependence t o abused subs tances , s t u d i e s t o uncover t h e genes r e spons ib l e f o r t h e s e v a r i a t i o n s .
MECHANISM OF SUPPORT
Support can be obta ined i n t h e form of R01 (Research P ro jec t Grants ) , R03 (Small Grants ) , R13 (Research Conference Grants ) , R29 ( F i r s t IndependentResearch Support and Trans i t i on Awards).
Vol. 19, No. 2, January 12, 1990 - Page 4
4
d
ELIGIBILITY
App l i ca t ion f o r r e s e a r c h g r a n t s may be submitted by any p u b l i c or p r i v a t enon-profi t or f o r - p r o f i t i n s t i t u t i o n such as u n i v e r s i t i e s , c o l l e g e s ,h o s p i t a l s , l a b o r a t o r i e s , u n i t s of S t a t e or l o c a l government, p r i v a t e i n d u s t r yand e l i g i b l e agencies o f t h e Federal Government. Women and minori tyi n v e s t i g a t o r s are encouraged t o apply.
APPLICATION PROCEDURES
Applicants should use t h e g r a n t a p p l i c a t i o n form PHS-398 (Rev. 10188). The t i t l e o f t h i s Program Announcement, "Molecular Approaches t o Drug Abuse Research," should be typed i n i t e m number 2 on t h e face page o f t h e PHS-398 a p p l i c a t i o n form . Appl i ca t ion k i t s con ta in ing t h e necessary forms and i n s t r u c t i o n s may be ob ta ined f rom,bus iness o f f i c e s or o f f i c e s o f sponsored r e sea rch a t most c o l l e g e s , u n i v e r s i t i e s , medical schools , and o t h e r major r e s e a r c h fac i l i t i es . If such a source is no t a v a i l a b l e , t h e fol lowing o f f i c e may be con tac t ed f o r t h e necessary a p p l i c a t i o n material:
Grants Management Branch Nat ional I n s t i t u t e on Drug Abuse 5600 F i s h e r s Lane, Room 10-25 Rockvi l le , Maryland 20857 Telephone: (301) 443-6710
The s igned o r i g i n a l and s i x ( 6 ) permanent,a p p l i c a t i o n should be s e n t t o :
D iv i s ion of Research Grants Nat ional I n s t i t u t e s of Heal th Westwood Building, Room 240 Bethesda, Maryland 20892SW
RECEIPT AND REVIEW SCHEDULE
l e g i b l e cop ie s o f t h e completed
The schedule f o r r e c e i p t and review is as fol lows:
Receipt Dates (New/Renewal)
Jun 1 / J u l I t Oct 1/Nov l t Feb l/Mar 1#
I n i t i a l Advisory Council Earliest Review Review S t a r t Date
Oct/Nov Jan/ Feb A p r 1 Feb/Mar May/ June J u l y 1 May/June Sep/Oct Dec 1
P Amended a p p l i c a t i o n s (new or renewal) are t o be submitted on t h e s e d a t e s .
App l i ca t ions r ece ived a f te r t h e above r e c e i p t d a t e s are s u b j e c t t o assignment t o t h e next review c y c l e or may be r e tu rned t o t h e a p p l i c a n t .
REVIEW PROCESS
The Divis ion of Research Grants, N I H , s e r v e s as a c e n t r a l p o i n t for receipt of a p p l i c a t i o n s f o r most d i s c r e t i o n a r y PHS g r a n t programs. App l i ca t ions r ece ived under t h i s announcement w i l l be ass igned t o an I n i t i a l Review Group ( I R G ) i n accordance with e s t a b l i s h e d PHS Referral Guidel ines . The I R G s , c o n s i s t i n gp r i m a r i l y o f non-Federal s c i e n t i f i c and t e c h n i c a l e x p e r t s , w i l l review t h e a p p l i c a t i o n s f o r s c i e n t i f i c and t e c h n i c a l merit. N o t i f i c a t i o n o f t h e review recommendations w i l l be s e n t t o t h e a p p l i c a n t after t h e i n i t i a l review. App l i ca t ions w i l l r e c e i v e a second-level review by an a p p r o p r i a t e Nat ional Advisory Council whose review may be based on p o l i c y c o n s i d e r a t i o n s as w e l l as s c i e n t i f i c merit . Only a p p l i c a t i o n s recommended f o r approval by t h e Council may be considered f o r funding.
App l i ca t ions submitted i n response t o t h i s announcement are not s u b j e c t t o t h e intergovernmental review requirements o f Executive Order 12372, as implementedthrough Department of Health and Human S e r v i c e s r e g u l a t i o n s a t 45 CFR P a r t 100 and are not s u b j e c t t o Heal th Systems Agency Review.
REVIEW CRITERIA
Criter ia f o r s c i e n t i f i c / t e c h n i c a l merit review of a p p l i c a t i o n s w i l l i nc lude t h e fol lowing: s i g n i f i c a n c e and o r i g i n a l i t y from a s c i e n t i f i c or t e c h n i c a l s t andpo in t of t h e g o a l s of t h e proposed r e sea rch ; adequacy o f t h e methodologyproposed t o c a r r y ou t t h e r e sea rch ; f e a s i b i l i t y of t h e p r i n c i p a l i n v e s t i g a t o rand o t h e r key r e s e a r c h personnel ; a v a i l a b i l i t y o f adequate f ac i l i t i e s , o t h e r
Vol. 19, No. 2, January 12, 1990 - Page 5
resources , and c o l l a b o r a t i v e arrangements necessary f o r t h e research;appropr i a t eness o f budget estimates f o r t h e p ~ o p o s e dresea rch a c t i v i t i e s ; and adequacy o f p rov i s ion f o r t h e p r o t e c t i o n o f human s u b j e c t s and t h e welfare of animal s u b j e c t s , as a p p l i c a b l e .
AWARD CRITERIA
Appl ica t ions recommended f o r approval by t h e Nat ional Advisory Council on DrugAbuse w i l l be considered for funding on t h e b a s i s of o v e r a l l s c i e n t i f i c and t e c h n i c a l merit o f t h e r e sea rch a s determined by peer review, Nat ional I n s t i t u t e on Drug Abuse needs and balance, and a v a i l a b i l i t y o f funds.
INQUIRIES
The gu ide l ines , o t h e r information about t h e drug abuse r e sea rch g r a n t s program, and f u r t h e r information about areas of i n t e r e s t descr ibed i n t h i s announcement may be obta ined by con tac t ing :
D r . Theresa Lee Biomedical Branch Nat iona l I n s t i t u t e on Drug Abuse 5600 F i s h e r s Lane, Room 10A-31 Rockvil le , Maryland 20857 Telephone: (301) 443-6300
f Other components of t h e Alcohol, Drug Abuse, and Mental Heal th Adminis t ra t ion (ADAMHA) sha re an i n t e r e s t i n s e v e r a l of t h e r e sea rch areas descr ibed i n t h i s announcement. P r o j e c t s may be submit ted under t h i s announcement t h a t address i s s u e s i n common with t h e Nat iona l I n s t i t u t e on Alcohol Abuse and Alcoholism. J o i n t funding of such p r o j e c t s is poss ib l e ; however, p r e a p p l i c a t i o n c o n s u l t a t i o n is s t r o n g l y encouraged. Appl ica t ions are considered for acceptance and ass igned according t o s t and ing I n s t i t u t e referral g u i d e l i n e s . Referencing t h i s announcement does no t guarantee assignment t o N I D A .
ERRATA
NCI/MARC SUMMER TRAINING SUPPLEMENT
P.T. 42, FF; K.W. 0720005, 0715035, 1014006
National Cancer I n s t i t u t e
Appl ica t ion Receipt Date: February 1, 1990
I n t h e above capt ioned Program Announcement publ i shed i n t h e December I , 1989 i s s u e o f t h e N I H Guide f o r Grants and Cont rac ts (Vol. 18, No. 431, a p o r t i o nof t h e first paragraph was omi t ted . The c o r r e c t ve r s ion appears below:
The Comprehensive Minori ty Biomedical Program (CMBP) o f t h e Div is ion o f Extramural A c t i v i t i e s (DEA) , Nat ional Cancer I n s t i t u t e ( N C I ) , i n v i t e s i n t e r e s t e d g ran tee i n s t i t u t i o n s t h a t have Minori ty Access t o Research Careers (MARC) g r a n t s t o apply f o r CMBP suppor t of MARC s c h o l a r s i n t e r e s t e d i n ob ta in ing l a b o r a t o r y r e sea rch experience a t t h e N C I . This programannouncement w i l l be i s sued on an annual b a s i s .
INVESTIGATIONS I N T O METHODS THAT REPLACE OR REDUCE VERTEBRATE ANIMALS USED I N RESEARCH, OR LESSEN THEIR PAIN AND DISTRESS
P.T. 34; K.W. 0755020, 0780010, 0780015, 0780020
National I n s t i t u t e s o f Heal th Alcohol, Drug Abuse, and Mental Heal th Adminis t ra t ion
The fo l lowing is a c o r r e c t i o n i n t h e NIH-wide Program Announcement e n t i t l e d , “ I n v e s t i g a t i o n s I n t o Methods That Replace Or Red,uce Ver t eb ra t e Animals Used I n Research, Or Lessen Thei r Pain And Distress” pub.lished i n t h e N I H Guide f o r Grants and Cont rac ts , Volume 18, No. 39, November 3, 1989. The Nat ional I n s t i t u t e on Deafness and Other Communication Disorders ( N I D C D ) was i n a d v e r t e n t l y omit ted from t h e l i s t o f p a r t i c i p a t i n g I n s t i t u t e s . The con tac t person f o r NIDCD is t h e fol lowing:
Vol. 19, No. 2 , January 1 2 , 1990 - Page 6
-
Dr. Ralph F. Naunton Acting Director, Extramural ProgramsNational Institute on Deafness and Other Communication Disorders
Federal Building, Room 1C-11 7550 Wisconsin Avenue Bethesda, Maryland 20892
.~r/ Telephone: (301) 496-1804
SSTHE MAILING ADDRESS GIVEN FOR SENDING APPLICATIONS TO THE DIVISION OF RESEARCH GRANTS OR CONTACTING PROGRAM STAFF IN THE WESTWOOD BUILDING IS THE CENTRAL MAILING ADDRESS FOR THE NATIONAL INSTITUTES OF HEALTH. APPLICANTS WHO USE EXPRESS MAIL OR A COURIER SERVICE ARE ADVISED TO FOLLOW THE CARRIER'S REQUIREMENTS FOR SHOWING A STREET ADDRESS. THE ADDRESS FOR THE WESTWOOD BUILDING IS:
5333 Westbard Avenue Bethesda, Maryland 20816
aU. 5. GOVERNNNNT PRINTING OFFICE:l990-261-138:00031
Vol. 19, No. 2, January 12, 1990 - Page 7