detailed program: educational sessions · 2018. 5. 2. · flanz, jay (usa) 8:30–10:00 junior...

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erapy light ion breakthrough cancer care particle radiotherapy healthcare trea education science proton therapy light ion breakthrough cancer care particle ght ion breakthrough cancer particle radiotherapy healthcare treatment innov Special Sessions Physics Clinics Biology Sponsored Lunch Symposium Detailed Program: Educational Sessions Monday, May 21 8:00–8:30 Junior Ballroom 1 Welcome 8:00 Welcome Words Metz, James (USA), Schreuder, Niek (USA) 8:15 PTCOG Overview – Opportunities Flanz, Jay (USA) 8:30–10:00 Junior Ballroom 1 Physics Session 1 8:30 ET 01 Rationale for Particles Tochner, Zelig (USA) 9:00 ET 02 Physics of Particle Beams Lu, Hsiao-Ming (USA) 9:30 ET 03 Radiobiology; Basis and Models Vazquez, Marcelo (USA) 10:30–12:00 Junior Ballroom 1 Physics Session 2 10:30 ET 04 Technical Aspects of Beam Delivery Flanz, Jay (USA) 11:00 ET 05 Modern Proton Treatment planning Mazal, Alejandro (France) 11:30 ET 06 RoundTable: Challenging case(s) for planning Dong, Lei (USA) 13:30–15:00 Junior Ballroom 1 Physics Session 3 13:30 ET 07 Uncertainties Nystrom, Håkan (Sweden) 14:00 ET 08 Patient Alignment and Motion Management Kruse, Jon (USA)

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  • particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer

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    Detailed Program: Educational SessionsMonday, May 21

    8:00–8:30 Junior Ballroom 1 Welcome 8:00 Welcome Words

    Metz, James (USA), Schreuder, Niek (USA)8:15 PTCOG Overview – Opportunities

    Flanz, Jay (USA)

    8:30–10:00 Junior Ballroom 1 Physics Session 18:30 ET 01

    Rationale for ParticlesTochner, Zelig (USA)

    9:00 ET 02Physics of Particle BeamsLu, Hsiao-Ming (USA)

    9:30 ET 03Radiobiology; Basis and ModelsVazquez, Marcelo (USA)

    10:30–12:00 Junior Ballroom 1 Physics Session 2 10:30 ET 04

    Technical Aspects of Beam DeliveryFlanz, Jay (USA)

    11:00 ET 05Modern Proton Treatment planningMazal, Alejandro (France)

    11:30 ET 06RoundTable: Challenging case(s) for planningDong, Lei (USA)

    13:30–15:00 Junior Ballroom 1 Physics Session 3 13:30 ET 07

    UncertaintiesNystrom, Håkan (Sweden)

    14:00 ET 08Patient Alignment and Motion ManagementKruse, Jon (USA)

  • particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer

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    14:30 ET 09Comparison of technologies and workflow: IMRT and IMPTPankuch, Mark (USA)

    15:30–17:00 Junior Ballroom 1 Physics Session 4 15:30 ET 10

    Commissioning, machine and patient QADong, Lei (USA)

    16:00 ET 11Physics Measurement tools required to operate a PT systemSchreuder, Niek (USA)

    16:30 ET 12Round Table: Patient Specific QA FocusBeltran, Chris (USA)

  • particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer

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    Tuesday, May 22

    8:00–10:00 Junior Ballroom 1 Clinical Session 1 8:00 ET 13

    Engagement strategies with payers and governmentsWarwick, Scott (USA)

    8:30 ET 14Selection Criteria for particlesHammer, Christian (Netherlands)

    9:00 ET 15Base of SkullWitt Nystrom, Petra (Sweden)

    9:30 ET 16CNSWeber, Damien (Switzerland)

    10:30–12:30 Junior Ballroom 1 Clinical Session 2 10:30 ET 17

    GIMetz, James (USA)

    11:00 ET 18Head and NeckLin, Alexander (USA)

    11:30 ET 19LymphomaHoppe, Brad (USA)

    12:00 ET 20LungRengan, Ramesh (USA)

    14:00–15:30 Junior Ballroom 1 Clinical Session 314:00 ET 21

    GU - ProstateLee, Andrew (USA)

    14:30 ET 22BreastMacDonald, Shannon (USA)

    15:00 ET 23Re-IrradiationPlasteras, John (USA)

  • particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer

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    16:00–17:00 Junior Ballroom 1 Clinical Session 416:00 ET 24

    Clinical Experience with IonsKamada, Tadashi (Japan)

    16:30 ET 25PediatricsMahajan, Anita (USA)

  • particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer

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    Wednesday, May 23

    8:00–10:00 Junior Ballroom 1 Shielding etc. Session8:00 ET 26

    Radiation ShieldingMeissner, Joern (Germany)

    8:30 ET 27AcceleratorsSchippers, Marco (Switzerland)

    9:00 ET 28Workflow EfficiencyBeltran, Chris (USA)

    9:30 ET 29Clinical Operations of Proton FacilitiesDixon, Jason (USA)

    10:30–12:00 Junior Ballroom 1 Clinic StartUp Session10:30 ET 30

    Facility SelectionGordon, Abram (USA)

    11:00 ET 31Facility StartupBreneman, John (USA)

    11:30 ET 32Future OutlookDurante, Marco (Italy)

    12:00–12:15 Junior Ballroom 1 Closing Word12:00 Closing Words

    Metz, James (USA), Schreuder, Niek (USA)

  • particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer

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    Thursday, May 248:00–8:30 Grand BallroomWelcomeChairs: Flanz, Jay (USA), Mascia, Anthony (USA)

    8:30–9:00 Grand BallroomPhysics Slam: “If You Could Only Invest in One Technology to Reduce Range Uncertainty, Would You Go For Improved Pre-Treatment Imaging (DECT/pCT) or In-Vivo Range Verification (Prompt Photon/PET Activation)”Chair: Lomax, Tony (Switzerland)8:30 IL 01

    Pre-treatment imagingMackay, Ranald (UK)

    8:30 IL 02In-vivo range verificationTeo, Kevin (USA)

    9:00–10:30 Grand BallroomDose Calculation and OptimizationChairs: Amos, Richard (UK), Zhang, Yongbin9:00 O 001

    New range margin recommendations based on dose calculation uncertaintiesSchuemann, Jan (USA)

    9:10 O 002Shortening delivery times for PBS proton therapy by reducing the number of proton spots without compromising dosimetric plan qualityBelosi, Maria Francesca (Switzerland)

    9:20 O 003Limitations of worst case robust optimization: a comparison with an all-scenario approachMa, Jiasen (USA)

    9:30 O 004L1-Spot: iteratively constrained spot optimization with L1-sparsity regularization for generating efficient proton PBS plansLin, Yuting (USA)

    9:40 O 005FROG – A new calculation engine for physical and biological dose investigations at CNAOChoi, KyungDon (Italy)

    9:50 O 006Development of an analytical dose-averaged LET calculation algorithm for spot-scanning proton therapyHirayama, Shusuke (Japan)

    10:00 O 007Determining end-of-range RBE in temporal lobe based on long-term follow-up data from patients with nasopharyngeal carcinomaZhang, Yingying (China)

    Detailed Program: Scientific Meeting

  • particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer

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    9:00–10:30 Junior Ballroom 1PediatricsChairs: TBC9:00 O 010

    The impact of LET/RBE modelling and robust analysis on skull-base and paediatric craniopharyngioma proton plans, benchmarked against VMATGutierrez, Andrea (UK)

    9:10 O 011Impact of radiotherapy modality on neuropsychological outcomes of pediatric brain tumor patientsGross, Jeffrey (USA)

    9:20 O 012Comparison of symptomatic and asymptomatic imaging changes following pencil-beam scanning and uniform scanning proton therapy for posterior fossa tumorsGross, Jeffrey (USA)

    9:30 O 013Factors Associated with Insurance-Related Referral Delays in Children Irradiated with Proton Therapy in the Pediatric Proton Consortium RegistryHess, Clayton (USA)

    9:40 O 014Craniospinal irradiation: Evaluation of proton range deviation using daily CBCTYao, Weiguang (USA)

    9:50 O 015Practice trends for vertebral body coverage of pediatric patients undergoing proton craniospinal irradiationMedek, Sara (USA)

    10:00 O 016Proton versus photon radiation therapy for pediatric head and neck rhabdomyosarcoma: disease control, overall survival, and toxicityCasey, Dana (USA)

    11:00–12:00 Grand BallroomKeynote LectureChair: Flanz, Jay (USA)

    KL 01The important science and technology challenges of todayMoniz, Ernest (USA)

    12:10 – 13:00 Grand BallroomVarian Lunch Symposium – Head and Neck Treatment Planning Utilizing Varian’s End-to-End SolutionChair: Lomax, Tony (Switzerland)

    Head and Neck treatment planning utilizing Varian’s end-to-end solutionMascia, Anthony (USA), Verbakel, Wilko, Dong, Lei (USA)

    13:00–14:00 Grand BallroomQuality Assurance 1Chairs: Nystrom, Håkan (Sweden), Lu, Hsiao-Ming (USA)

  • particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer

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    13:00 O 019Gamma Electron Vertex Imaging (GEVI) for Proton Beam Range Measurement: Experimental ResultsKim, Sung Hun (Korea)

    13:10 O 020How risky is 4D planning? – A FMEA based human error comparison of 3D/4D PT QA planning risks performed at CPT/PSIEmert, Frank (Switzerland)

    13:20 O 021Proton range verification through acoustic measurementsNie, Wei (USA)

    13:30 O 022Intrafractional visualisation of the scanning pencil beam in 12C radiotherapyFelix-Bautista, Renato (Germany)

    13:40 O 023An activity to improve the quality through the dose intercomparison by end-to-end test in carbon-ion radiation therapy centers in JapanMizuno, Hideyuki (Japan)

    13:00–14:00 Junior Ballroom 1Biology DifferencesChairs: Kondo, Rika (Japan), Nowrouzi, Ali (Germany)

    13:00 O 024Differences in human endothelial cell activation after irradiation with photons vs. protons in the proximal and distal spread-out Bragg peakVatner, Ralph (USA)

    13:10 O 025Drosophila melanogaster may be a useful model organism to study biological effects of proton radiationNakajima, Koichiro (Japan)

    13:20 O 026Radiobiological impact of mixed field from target fragments in proton treatment plansBellinzona, Valentina Elettra (Italy)

    13:30 O 027Differential inflammatory and metabolic gene expression profiles of murine and human cancer cell lines after proton vs. photon irradiationSinghaviranon, Summit (USA)

    13:40 O 028Comparison of the effect of X-ray, carbon ion beam and proton beam on metastatic potential.Kondo, Rika (Japan)

    13:50 O 029Hadron minibeam radiation therapy: disentangling molecular and cellular effects in glioma cells with synchrotron-based infrared microspectroscopyPrezado, Yolanda (France)

  • particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer

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    14:00–15:00 Grand BallroomQuality Assurance 2Chairs: Sahoo, Narayan (USA), Lin, Liyong (USA)

    14:00 O 030Is deposited energy a useful metric in the quality assurance of pencil-beam-scanning plans?Slopsema, Roelf (USA)

    14:10 O 031Proton beam ruler – a fast proton range measurement tool using a scintillator block and cameraRobertson, Daniel (USA)

    14:20 O 032Highlights from the 2nd International Proton Treatment Efficiency Workshop sponsored by the PTCOG Treatment Efficiency SubcommitteeMundy, Daniel (USA)

    14:30 O 033In-room characterisation, using an anthropomorphic phantom, of a novel monitor exploiting secondary charged particles emission in light ion PT treatmentsSarti, Alessio (Italy)

    14:40 O 034Scintillator-based system for transversal dose pro files reconstructionCatalano, Roberto (Italy)

    14:50 O 035Implementation of a non-invasive online beam monitor at a 60 MeV proton therapy beamlineYap, Jacinta S. L. (UK)

    14:00–15:00 Junior Ballroom 1Breast / GIChairs: Hong, Ted (USA), Meier, Teresa (USA)

    14:00 O 036Prospective study of 3 fraction pencil-beam scanning partial breast irradiation: early provider and patient- reported outcomes of a novel regimenMutter, Robert (USA)

    14:10 O 037Improved long-term patient-reported health and well-being outcomes of early-stage breast cancer treated with partial breast proton therapy.Teichman, Sandra (USA)

    14:20 O 038Initial experience with barrier film dressing for dermatitis prophylaxis in breast proton therapyCorbin, Kimberly (USA)

    14:30 O 039Proton Beam Therapy for Hepatocellular Carcinoma associated with Inferior Vena Cava Tumor ThrombusSekino, Yuta (Japan)

  • particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer

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    14:40 O 040Proton radiotherapy for locally advanced pancreatic cancer (LAPC) – limiting duodenal toxicity.Vitek, Pavel (Czechia)

    14:50 O 041Is proton SBRT an attractive option for liver metastases? Results of a 5-year observational study for 80 hepatic lesionsSufficool, Daniel (USA)

    15:30–17:00 Grand BallroomBeam Delivery and Nozzle DesignChairs: Schreuder, Niek (USA), Kanematsu, Nobuyuki (Japan)

    15:30 O 042Innovative strip silicon detectors for proton beam monitoring: preliminary resultsVignati, Anna (Italy)

    15:40 O 043Dynamic beam current control for improved dose accuracy in PBS proton therapyBula, Christian (Switzerland)

    15:50 O 044Commissioning of a unique penumbra sharpening adaptive aperture of HYPERSCANKang, Minglei (USA)

    16:00 O 045External beam radiotherapy for ocular melanoma: A comparative study low energy protons vs. pencil scanning high energy protons vs CyberknifeGerard, Anais (France)

    16:10 O 046Utilization of an isocentric rotating chair for treating head/neck cancer at seating in fixed particle beamlineHsi, Wen Chien (China)

    16:20 O 047Clinical implementation of the patient-specific apertures used in commercial proton pencil beam scanning systemsLiu, Haoyang (USA)

    16:30 O 048A novel deliver sequence and efficiency optimization algorithm for Spot-Scanning Proton Arc therapyDing, Xuanfeng (USA)

    16:40 O 049Superconducting gantry for proton therapy with a large momentum acceptanceNesteruk, Konrad Pawel (Switzerland)

  • particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer

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    15:30–16:30 Junior Ballroom 14D Treatment, Delivery and ModellingChairs: Riboldi, Marco (Italy), Lamba, Michael (USA)

    15:30 O 0504D dose evaluation for PBS proton treatment of pancreatic cancer using repeated 4DMRI datasetsDolde, Kai (Germany)

    15:40 O 0514D robust optimization including time structures can reduce the interplay effect in proton pencil beam scanning radiotherapyEngwall, Erik (Sweden)

    15:50 O 052Robust treatment planning with 4D intensity modulated particle therapy for multiple targets in stage IV non-small cell lung cancerWolf, Moritz (Germany)

    16:00 O 053Evaluation of 4D plan robustness using lung 4DCT(MRI)Krieger, Miriam (Switzerland)

    16:10 O 054Alternating intra-field scan direction in rescanning for improved motion mitigationFattori, Giovanni (Switzerland)

    16:20 O 055Feasibility of noninvasive cardiac ablation utilizing intensity modulated proton therapy to treat ventricular tachycardiaGoddu, S. Murty (USA)

  • particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer

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    Friday, May 25

    8:00–8:30 Grand BallroomClinics Slam: “Protons There or Photons Here”Chair: Mahajan, Anita (USA)8:00 IL 03

    Suh, John (USA)8:00 IL 04

    Shih, Helen (USA)

    8:30–10:00 Grand BallroomInterdisciplinary Session – Cost Effectiveness ResearchChair: Flanz, Jay (USA)8:30 O 056

    Plan analysis tools to quantify proton IMPT complexityGosling, Andrew (UK)

    8:39 O 057Is the dose-mean LET an appropriate predictor for RBE?Graeff, Christian (Germany)

    8:48 O 058The development of a unique co-linearity set-up and test phantom for a Patient positioner mounted image guidance systemSchreuder, Niek (USA)

    8:57 O 059Efficiency improvements in the periodic quality assurance procedures at the Shanghai Proton and Heavy Ion Center SPHICSchlegel, Nicki (China)

    9:06 O 060Utilizing imaging thresholds to improve setup efficiency for proton therapy patientsPetro, Scott (USA)

    9:15 O 061Which proton imaging setup should we use in a proton therapy facility?Krah, Nils (France)

    9:24 O 062Estimation of the risk for sequelae following radiosurgery of liver metastasesMondlane, Gracinda (Sweden)

    9:33 O 063Normal tissue complication probability models in plan evaluation of children with brain tumours referred to proton therapyStokkevag, Camilla (Norway)

    9:42 O 064Helical Tomotherapy alone versus helical Tomotherapy + proton beam therapy combination in nasopharynx and oropharynx cancer: comparison of acute toxicityPark, Seung-Gyu (Korea)

    9:51 O 065Cost comparison of hepatocellular carcinoma treatment with either proton radiotherapy or transarterial chemoembolization as assessed from an randomized clinical trialBush, David (USA)

  • particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer

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    10:30–11:30 Grand BallroomInvited Panel: Interdiciplinary Session on HypofractinationChair: Nystrom, Håkan (Sweden)10:30 IL 05

    The ClinicianTsujii, Hirohiko (Japan)

    10:30 IL 06The ClinicianMutter, Robert (USA)

    10:30 IL 07The BilologistVazquez, Marcelo (USA)

    10:30 IL 08The PhysicistLomax, Tony (Switzerland)

    11:40 – 12:30 Grand BallroomRaySearch Lunch Symposium – Advancing Cancer Treatment Through Software InnovationChair: Mlyn, Marc (USA)

    A comprehensive approach to lung treatment with 4D-robust optimization and MC dose calculation in RayStationChang, Chang (USA)The sharper edge: Clinical benefits of aperture-based PBSGondi, Vinai (USA)

    11:40 – 12:30 Junior Ballroom 1IBA / Philips Lunch Symposium – Advanced Imaging and Planning for Proton Therapy

    Monoisocentric intensity modulated proton therapy for bilateral breast cancerFagundes, Marcio (USA)Commissioning and planning optimization for open IMPT gantriesLambert, JamilMRI for planning and on-therapy monitoring of proton therapy patientsHua, Chiaho (USA)

  • particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer

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    13:30–15:00 Grand BallroomHead and Neck / GUChairs: Chang, Joseph Tung-Chieh (Taiwan), Barrett, William (USA)13:30 O 066

    Stereotactic proton radiotherapy in the treatment of low and intermediate risk prostate cancer – 2-years resultsKubes, Jiri (Czechia)

    13:40 O 067Prospective patient-reported quality-of-life outcome of the initial 100 prostate cancer treated with the first clinical image-guided compact pencil-beam proton unitWang, Jake (USA)

    13:50 O 068Peripheral lymphocyte subpopulation variation and hematologic changes after carbon ion radiotherapy in patients with prostate cancerYang, Zhangru (China)

    14:00 O 069Minimal acute toxicity in major salivary gland patients after proton beam therapy: Outcomes from the Proton Collaborative Group REG001-09 trialChuong, Michael (USA)

    14:10 O 070Boron Neutron Capture Therapy for Locally Recurrent Head and Neck Squamous Cell Carcinoma: A Retrospective Analysis of Dose ResponseKoivunoro, Hanna (Finland)

    14:20 O 071Comparison of dose-response of acute mucositis after C-ion RT for patients treated at NIRS and CNAOFossati, Piero (Austria)

    14:30 O 072Patient and public involvement in design of a phase III trial comparing IMPT versus IMRT in low risk oropharyngeal cancerHague, Christina (UK)

    13:30–15:00 Junior Ballroom 1Accepting & Commissioning of New FacilitiesChairs: Mazal, Alejandro (France), Dong, Lei (USA)13:30 O 073

    Commissioning of the ProNova SC360 PBS for first patient treatment at the Provision CARES Proton Therapy CenterDerenchuk, Laddie (USA)

    13:40 O 074Implementation of clinical Helium beams at the Heidelberg Ion Therapy CentreHaberer, Thomas (Germany)

    13:50 O 075Commissioning of the first mevion HYPERSCAN proton pencil beam scanning systemPang, Dalong (USA)

    14:00 O 076Commissioning of the neutron therapeutics BNCT system at Helsinki University HospitalSmick, Noah (USA)

  • particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer

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    14:10 O 077Clinical integration of RayStation, ARIA, and adaPT for pencil beam scanning proton therapyRana, Suresh (USA)

    14:20 O 078Design and dosimetric characterization of 3D printed small animal immobilization and collimator for pencil beam scanning proton research roomMascia, Anthony (USA)

    14:30 O 079A strategy to minimize commissioning time for a pencil-beam-scanning proton systemHsi, Wen Chien (USA)

    14:40 O 080System architecture and design principles for cost effective design of a compact proton therapy systemZwart, Townsend (USA)

    15:30–17:30 Grand BallroomBiology Optimisation and Translational ResearchChairs: Wells, Susanne (USA), Vatner, Ralph (USA)15:30 O 081

    Potential of particle therapy in combination with Ipilimumab and Nivolumab in B16 melanoma and LM8 osteosarcoma mouse modelsHelm, Alexander (Italy)

    15:40 O 082Proton minibeam radiation therapy widens the therapeutic window for gliomasPrezado, Yolanda (France)

    15:50 O 083Anti-tumor and anti-metastasis effects of carbon-ion radiotherapy combined with anti-CTLA4 antibodyMa, Liqiu (Japan)

    16:00 O 084Targeting mitochondrial fission for the sensitization of lymphoma cells to proton therapySertorio, Mathieu (USA)

    16:10 O 085Nano-molar concentrations of duocarmycin SA significantly enhances the effects of proton irradiation on human glioblastoma cellsVazquez, Marcelo (USA)

    16:20 O 086Radiosensitization effect of Talazoparib, a PARP inhibitor, on Glioblastoma stem cells exposed to X-Rays and Carbon ionsSaintigny, Yannick (France)

    16:30 O 087Evaluation of the impact of proton minibeam radiation therapy on motor, emotional and cognitive functionsLamirault, Charlotte (France)

    16:40 O 088Molecular mechanism of PD-L1 upregulation in cancer cells after irradiationSato, Hiro (Japan)

  • particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer

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    16:50 O 089Determining the RBE of particle irradiation via development of a novel quantitative and functional DNA-double strand break repair assayNowrouzi, Ali (Germany)

    17:00 O 090Dissecting microRNA regulation in human intestinal organoids after photon and clinical rasterscanning proton and carbon ion beamsNowrouzi, Ali (Germany)

    17:10 O 091Multicellular 3-dimensional spheroid models to study tumor-stroma-immune cell response to proton radiationSertorio, Mathieu (USA)

    15:30–16:30 Junior Ballroom 1Absolute and Relative DosimetryChairs: Slopsema, Roelf (USA), Vondracek, Vladimir (Czechia)15:30 O 092

    Innovative device for online in-vivo dose monitoring based on charge unbalance in patients undergoing radiotherapyPetringa, Giada (Italy)

    15:40 O 093Monte Carlo calculated correction factors for a proton calorimeter in clinical proton beamsRomano, Francesco (UK)

    15:50 O 094Towards prompt gamma spectroscopy for C-12 range control: development of a synchro-tron-dedicated systemDal Bello, Riccardo (Germany)

    16:00 O 095Detection of ionacoustic signal from low intensity proton and carbon ion beamsChen, Zhi (China)

    16:10 O 096Evaluation of the particle transport accuracy in the FLUKA Monte Carlo code for proton therapy dosimetry applicationsLourenco, Ana (UK)

    16:20 O 097A comprehensive evaluation of air gaps in pencil beam scanning proton therapy: dosimetric impact and clinical toleranceXiao, Zhiyan (USA)

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    16:30–17:30 Junior Ballroom 1Sarcoma / LungChairs: Rengan, Ramesh (USA)16:30 O 098

    Intensity-modulated proton therapy with small spots and volumetric-modulated arc therapy in the treatment of stage III non-small cell lung cancerLiu, Chenbin (USA)

    16:40 O 099Preliminary observation of carbon ion radiotherapy for tracheal adenoid cystic carcinomaChen, Jian (China)

    16:50 O 100Definitive proton based radiotherapy for unresected chordomas: local results, tolerability, and patterns of progressionChen, Yenlin (USA)

    17:00 O 101Proton-based high-dose pre-operative radiation is associated with higher local control than low-dose pre-operative radiation with equivalent rate of wound complicationMaquilan, Genevieve (USA)

    17:10 O 102Integration of electrocardiogram-gated CT with coronary angiography (E-CTA) and pencil beam scanning proton therapy for the treatment of mediastinal lymphomasLester, Scott (USA)

    17:20 O 103Clinical results of phase I trial of preoperative IMPT with simultaneously integrated boost(SIB) to the high-risk margin for retroperitoneal sarcomas(RPS)Chen, Yen-lin

  • particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer

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    Saturday, May 26

    8:00–8:30 Grand BallroomBiology Slam: “Publish and Vanish: Is this the Fate of Biomarkers for Charged Particle Radioresponse?”Chair: Vazquez, Marcelo (USA)8:00 IL 09

    Story, Michael (USA)8:00 IL 10

    Speaker TBC

    8:30–10:00 Grand BallroomBiomarkers and Biological ModellingChairs: Story, Michael (USA), Kirkby, Karen (UK)8:30 O 104

    Calculating dose weighted mean lineal energy for input into the microdosimetric kinetic model for predicting proton RBENewpower, Mark (USA)

    8:40 O 105Monte Carlo simulations of direct DNA damage on gold nanoparticle enhanced proton therapySotiropoulos, Marios (UK)

    8:50 O 106In-silico modelling of Non-Homologous End Joining and Homologous Recombination can demonstrate mechanistic interactions between repair pathwaysIngram, Sam (UK)

    9:00 O 107Infidelity in proton therapy: Getting double strand breaks back togetherHenthorn, Nicholas (UK)

    9:10 O 108Is there a clinical indication of the need of variable proton RBE in patients with hypothyroidism?Yepes, Pablo (USA)

    9:20 O 109SDD: A standardised data format to record DNA damage and facilitate collaborationWarmenhoven, John-William (UK)

    9:30 O 110Nano-vesicles are a potential tool to monitor therapeutic efficacy of carbon ion radiotherapy in prostate cancerYu, Qi (China)

    9:40 O 111MRI radiomic features to predict treatment response in carbon ion treated prostate cancer patientsWu, Shuang (China)

    9:50 O 112Proteogenomic analysis of bystander effects in chondrosarcoma cells co-cultured with chondrocytesSaintigny, Yannick (France)

  • particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer care particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer particle radiotherapy healthcare treatment innovation education science proton therapy light ion breakthrough cancer

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    8:30–10:00 Junior Ballroom 1Imige Guidance and IGPT / Adaptive TherapyChairs: Winey, Brian (USA), Mascia, Anthony (USA)8:30 O 113

    Online plan adaptation of head and neck IMPT treatments based on cone beam CT imaging and GPU Monte Carlo simulationsBotas, Pablo (USA)

    8:40 O 114Functional MRI for early changes detection and adaptive planning in proton-therapy: preliminary investigationsBuizza, Giulia (Italy)

    8:50 O 115A method to evaluate the clinical utility of proton radiography for geometric patient alignment.Pankuch, Mark (USA)

    9:00 O 116Online IMPT adaptation using fast, automatic and robust dose restorationJanssens, Guillaume (Belgium)

    9:10 O 117Short-lived positron emitters for in-beam Positron Emission Tomography (PET) verification of helium therapyOzoemelam, Ikechi (Netherlands)

    9:20 O 118Transducer specifications for thermoacoustic range verification of pencil beams delivered by a synchrocyclotronPatch, Sarah (USA)

    9:30 O 119Prompt Gamma Spectroscopy for range control with CeBr3: enhanced spectra detection for proton and carbon beamsDal Bello, Riccardo (Germany)

    9:40 O 120Virtual 4DCT for image guided proton therapy of moving tumorsLin, Liyong (USA)

    9:50 O 121Investigation of helium as a range probe in carbon ion therapyGraeff, Christian (Germany)

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    10:30–12:00 Grand BallroomCNS / EyeChairs: Mishra, Kavita (USA), Weber, Damien (Switzerland)10:30 O 122

    Phase I/II randomized study of proton beam irradiation with anti-vascular endothelial growth factor for exudative age-related macular degenerationMishra, Kavita (USA)

    10:40 O 123Treatment of conjunctival carcinomasThariat, Juliette (France)

    10:50 O 124Eye tracking system for patient positioning in ocular proton therapyVia, Riccardo (Italy)

    11:00 O 125Hyperfractionated high dose proton beam radiotherapy for clival chordomas in close proximity to the brainstemTsuboi, Koji (Japan)

    11:10 O 126Long-term results of hypo fractionated proton therapy for choroidal HemangiomasMeniai-Merzouki, Fatima (France)

    11:20 O 127Proton therapy for iris melanoma: a series from Institut Curie Proton therapy CenterDendale, Remi (France)

    11:30 O 128Increase of pseudoprogression and treatment related effects in low-grade glioma patients treated with proton radiation and temozolomideDworkin, Michael (USA)

    11:40 O 129Patterns of care in proton beam radiotherapy for clival chordomaPater, Luke (USA)

    11:50 O 130Proton therapy for low grade gliomas: A prospective Swedish multicentre studyWitt Nystrom, Petra (Sweden)

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    10:30–12:00 Junior Ballroom 1Treatment PlanningChairs: Kruse, Jon (USA), Schwarz, Marco (Italy)10:30 O 131

    Clinical application of dual-energy computed tomography improves stopping-power predictionWohlfahrt, Patrick (Germany)

    10:40 O 132Using realistic and animal tissue phantoms to validate the RayStation Monte Carlo dose calculation algorithmSchreuder, Niek (USA)

    10:50 O 133Harmonization of the treatment planning approach for head-and-neck cancer using pencil beam scanning: First report of the IPACS collaboration groupStock, Markus (Austria)

    11:00 O 134Testing dose calculations with stopping power ratio images constructed from dual-energy CT in a commercial treatment planning systemMossahebi, Sina (USA)

    11:10 O 135Experimental validation of dual energy CT based proton stopping power ratio estimation in organic tissuesTaasti, Vicki (Denmark)

    11:20 O 136Radiation dose-painting with protons vs. photons for head-and-neck cancerSmulders, Bob (Denmark)

    11:30 O 137Alignment and tracking algorithms for the MIMOSA28 detectors for ion radiotherapyReidel, Claire-Anne (Germany)

    11:40 O 138Feasibility evaluation of proton-based, Spatially Fractionated Radiotherapy (SFRT) using a GRID techniqueYu, Jen (USA)O 139MR-only IMPT planning for prostate cancer: a proof of conceptDepauw, Nicolas (USA)

    12:00–12:30 Grand BallroomClosing WordChair: Flanz, Jay (USA)12:00 Closing Word

    Jay Flanz (USA)

    Detailed_Program-Educational_SessionsDetailed_Program-Scientific_Meeting