detailed scientific programme - eapcct2017 · detailed scientific programme 24 cme credits of the...

16 – 19 May

DETAILED SCIENTIFIC PROGRAMME

24 CME Credits of the Swiss Society of Clinical Pharmacology and Toxicology

The 37th Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) has been organised by the following Committees:

EAPCCT Scientific and Meetings Committee

EAPCCT Board

Congress secretariat

SOCIAL PROGRAMME

Welcome Reception (included in congress registration) at Volkshaus Basel on Wednesday 17 May 2017 at 19:00 hrs. The Volkshaus Basel is located about 10 minutes’ walk from the Congress Center Basel at Rebgasse 12-14, near Claraplatz. The new Volkshaus Basel, built in 1925, has been undergoing architectural intervention by renowned architects Herzog & de Meuron to revitalize the diversity of uses to combine cultural events, arts and gastronomy in one and the same building.

The Conference Dinner will be held in the historic guildhall (Zunftsaal) of the Restaurant Safranzunft located in the centre of the Old Town of Basel near Marktplatz, 15 minutes’ walk or 10 minutes by tram from the Congress Center at Gerbergasse 11 on Friday 19 May 2017 at 19:30 hrs (Swiss Francs 100). The noble Safran Guild originated in the middle ages as one of the main four merchant guilds, amongst a total of twenty guilds in Basel. Today Safran Guild is tasked with the care of maintaining the traditions it was built upon, and the continued nurture and growth of relationships within the community.

Tickets can be bought at the registration desk. Tickets are limited in number by the venue, so please book early to avoid disappointment.

Ana Ferrer Dufol, ChairMark Zammit, General SecretaryNicola Bates, Abstract EditorLisa Breitner, AdministratorRegis BedryPieter BrekelmansMiran Brvar

Alexander Campbell Paul DarganMichael EddlestonFlorian EyerLotte HoegbergKnut Erik HovdaDavide Lonati

Charles McKayBruno Megarbane Robert Palmer Steven Seifert Horst Thiermann Martin Wilks Sergey Zakharov

Bruno Megarbane, PresidentAlexander Campbell, Past-PresidentMartin Wilks, President-ElectMark Zammit, General SecretarySergey Zakharov, Treasurer

Pieter Brekelmans Miran BrvarPatricia CaseyPaul DarganAna Ferrer Dufol

Lotte Hoegberg Peter Hulten Davide Lonati Horst Thiermann Geert Verstegen

Maria Cubí, 4 Pral08006 Barcelona – [email protected]

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Room Montreal, Tuesday 16 May 2017

Toxicological analysis and contribution to diagnosis and patient management in clinical toxicology

Session chair: Bruno Mégarbane, Miran Brvar

09:00 - 09:30 Chromatographic techniques – applications for ethanol and toxic alcohol poisoning Ana Ferrer Dufol, Clinical University Hospital, Zaragoza, Spain09:30 - 10:00 Mass spectrometry – applications and future development Olivier Laprévote, Universite Paris Descartes, AP-HP, Paris, France10:00 - 10:30 Development of library search-based screening system Hans Maurer, Saarland University, Homburg (Saar), Germany

At the end of this session the audience should be able to:• Describe the analytical principles involved in chromatographic techniques applied to

toxicological analysis and their usefulness as the gold standard for quantification of alcohols with reference to the flame ionization detector (FID)-based technique for follow-up of antidote treatment in methanol poisoning

• Explain how mass spectrometry compares to other methods for the toxicological analysis of a patient

• Understand the relevance of drug screening approaches for clinical toxicology with reference to the principles, advantages and limitations of target and library-based screening approaches and their use in case-solving in clinical toxicology

10:30 - 11:00 Coffee

Session chair: Alex Manini, Carlo Locatelli

11:00 - 11:30 Tox analysis for new psychoactive substance screening in biological matrices: where do we stand today? Markus R Meyer, Saarland University, Homburg (Saar), Germany11:30 - 12:00 Metal detection assays for exposure diagnosis and monitoring Souleiman EL Balkhi, Centre Hospitalier Universitaire de Limoges, Limoges, France12:00 - 12:30 Tox analysis for risk assessment: methodological requirements Michael G Holland, SUNY Upstate Medical University, Syracuse, USA

At the end of this session the audience should be able to:• Evaluate the limitations of commonly available drug testing systems for analysis of

novel psychoactive substance (NPS) and describe alternatives, which might be used • Recognise the circumstances where metals determination is useful or mandatory in

the diagnosis and management of exposure • Describe the types of equipment used for real-time monitoring of an air contaminant,

how they work and what equipment is suitable for the various types of air contaminants of interest (gases, particulates, etc)

12:30 – 13:30 Lunch

PRE-CONGRESS SYMPOSIUM

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Room Montreal, Tuesday 16 May 2017

Toxicological analysis and contribution to diagnosis and patient management in clinical toxicology (cont)

Session chair: Charles McKay, Daniela Pelclova

13:30 - 14:00 Tox analyses for substances of abuse and psychotropic drugs in the emergency room (ER) Matthias Liechti, University Hospital Basel, Switzerland14:30 – 15:00 Usefulness of toxicological analysis for the management of cardiotoxicant poisonings Bruno Mégarbane, Paris-Diderot University, Lariboisière Hospital, Paris, France15:00 – 15:30 TOXI-triage - can pesticide and toxic alcohol exposure be diagnosed by breathalyzer Michael Eddleston, University of Edinburgh, UK

At the end of this session the audience should be able to:• Evaluate sensitivity and specificity of immunoassays and chromatographic methods

and their relevance in the ER setting• Evaluate the benefits and limitations in the interpretation of the blood concentration

of a cardiotoxicant drug, if available, to manage a poisoned patient• Explain the potential role of Gas Chromatography - Ion Mobility Spectrometry in

detecting toxic alcohol and pesticides in the breath of poisoned patients

15:30 – 16:00 Coffee

Session chair: Horst Thiermann, Alexander Campbell

16:00 – 16:30 Forensic toxicology - how to combine selectivity, sensitivity, and robustness Stephen Morley, University of Leicester Hospital Trust, Leicester, UK16:30 - 17:00 Hair analysis: when, how and why? Pascal Kintz, X-Pertise Consulting, Strasbourg, France17:00 – 17:30 Postmortem tox analysis: principles and interpretation Thomas Kraemer, University of Zurich, Switzerland17:30 – 18:00 Biomedical verification of chemical warfare agent exposure Harald John, Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany

At the end of this session the audience should be able to:• Evaluate the advantages and disadvantages of the range of analytical instruments

used by clinical and forensic toxicology laboratories• Understand the interest of testing drugs in hair for historical monitoring • Explain the differences between post-mortem analysis and analysis in a living person• Describe the fate of chemical warfare agents (nerve and blister agents) in vivo

following the principles of biotransformation to form hydrolyzed agents and proteins adducts that can be used as biomarkers detected by either GC-MS or LC-MS/MS-based techniques

PRE-CONGRESS SYMPOSIUM MAIN CONGRESS

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Room Montreal, Wednesday 17 May 2017 (morning)

Plenary Lecture followed by Toxicology of Migration & Short Orals (1)

Session chair: Alexander Campbell, Ana Ferrer Dufol

08:55 – 09:00 Welcome and opening Bruno Mégarbane, President EAPCCT09:00 – 09:45 Public health aspects of the migrant crisis and the role of WHO Joanna Tempowski, World Health Organization, Geneva, Switzerland09:50 – 10:10 Rapid Risk Assessment of chemical/toxicological incidents with cross-border threats to public health Raquel Duarte Davidson, Public Health England, Chilton, UK10:10 – 10:30 Incidents related to illegal importation of chemicals in the US Michael Holland, SUNY Upstate Medical University Syracuse, USA

At the end of this session the audience should be able to:• Discuss the key health problems facing migrants and measures that can be put in

place to manage these• Understand the processes required for a rapid risk assessment of serious cross

border threats to public health from chemicals• Describe incidences involving importation of illegal toxic chemicals into the US

10:30 – 11:10 Coffee and electronic posters

Session chair: Alvin Bronstein, Viorela Nitescu

11:10 – 11:30 Specific poisonings risks for migrants or caused by migrating poisons in Germany Herbert Desel, Kathrin Begemann and Esther Feistkorn

At the end of this lecture the audience should be able to:• Describe the specific poisoning risks for migrants arriving in Germany and the novel

risks for the population caused by increased import of foreign products to Germany

11:30 Poisonings involving refugees in Northern Germany during the migrant crisis, 2015-2016 (abstract no. 7)

Elke Färber, Rafael Wagner, Annette Groeneveld, Adrienne Kilian, Martin EbbeckeUniversity Medical Center, Göttingen, Germany

11:35 Exposures in refugees reported to the Poisons Information Centre Erfurt, 2007-2016 (abstract no. 8)

Germaine Frimlova, Helmut Hentschel, Dagmar Prasa, Mandy Gollmann, Gesine Liebetrau, Bettina Plenert, Anne Stürzebecher, Michael DetersPoisons Information Centre Erfurt, Erfurt, Germany

11:40 Two cases of ayahuasca poisoning: a poison crossing borders (abstract no. 9) Mari A Bjornaas, Oona Dunlop, Dag JacobsenOslo University Hospital Ulleval, Oslo, Norway

MAIN CONGRESS

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MAIN CONGRESS

Room Montreal, Wednesday 17 May 2017 (morning)

Short Orals (1) (cont)

11:45 Most amatoxin poisonings in Sweden occur in persons of non-Swedish background (abstract no. 10)

Bengt Carlvik, Erik LindemanSwedish Poisons Information Centre, Stockholm, Sweden

11:50 Unusual mushroom poisoning in an immigrant: a case report (abstract no. 11) Nena Golob, Mojca Dobaja, Miran BrvarUniversity Medical Centre Ljubljana, Ljubljana, Slovenia

11:55 Increased migration to Sweden and increased incidence of isoniazid poisonings (abstract no. 12)

Lisa Franzén, Christina Didner, Peter HultenSwedish Poisons Information Centre, Stockholm, Sweden

12:00 Drugs crossing borders: unexpected dosing error with identical formulation of prazepam (Lysanxia®) (abstract no. 13)

Jonas Moens, Martine Mostin Belgian Poison Center, Brussels, Belgium12:05 § Occupational inhalation poisoning with the veterinary antibiotic tiamulin (abstract no. 14)

Mojca Dobaja (1), Lucija Sarc (1), Marija Jamsek (1), Darja Gnezda Mugerli (2), Bor Antolic (1), Miran Brvar (1)

(1) University Medical Centre Ljubljana, Ljubljana, Slovenia; (2) General Hospital “Dr. Franca Derganca” Nova Gorica, Nova Gorica, Slovenia

12:10 Occupational-related fatal case of acute methyl ethyl ketone peroxide ingestion: case report and review of the literature (abstract no. 15)

Yao-Min Hung (1), Te-Hao Wang (2)

(1) Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; (2) Taipei Veterans General Hospital, Taipei, Taiwan

12:15 Suspected metal fume fever from domestic exposure to lead fumes while making lead sinkers in an enclosed space (abstract no. 16)

William PA Ryan (1), Andis Graudins (2)

(1) Monash Health, Dandenong, Australia; (2) Monash Health and Monash University, Dandenong, Australia

12:20 Descriptive study of an urban academic toxicology consultation service, 2012-2016 (abstract no. 17)

Kristin McCloskey, Ryan Surmaitis, David Goldberger, Rita McKeever, David Vearrier, Zachary Schwartzkopf, Michael I GreenbergDrexel University College of Medicine, Philadelphia, US

12:25 - 12:30 General discussion

12:30 - 14:00 Lunch and posters

§ Shortlisted for Taylor & Francis best case study award

MAIN CONGRESS

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MAIN CONGRESS MAIN CONGRESS

Room Singapore, Wednesday 17 May 2017 (morning)

Antidotes: Something Old, Something New, Something Borrowed, Something Blue

Session chair: Martin Wilks, Christopher Yates

09:50 – 10:10 New antidotal strategies for nerve agent poisoning Horst Thiermann, Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany10:10 – 10:30 Use of pre-hospital ethanol administration to improve outcome in methanol mass poisoning outbreaks: the Czech experience. Sergey Zakharov, General University Hospital, Charles University, Prague, Czech Republic

At the end of this session the audience should be able to:• Describe promising approaches, e.g. enhanced elimination of poison or modulation

of nicotinic receptors, which are under investigation in order to close existing gaps in the treatment of patients with nerve agent poisoning in mass casualty scenarios

• Describe the effects of pre-hospital ethanol administration on patients with suspected methanol poisoning during mass poisoning outbreaks on survival and prevalence of long-term health sequelae


Session chair: Richard Dart, Carlo Locatelli

11:10 – 11:30 Optimising the use of DMSA/succimer in lead poisoning Sally Bradberry, National Poisons Information Service (Birmingham Unit), Birmingham, UK11:30 – 11:50 Challenges in methylene blue therapy Robert Hoffman, NYU School of Medicine, New York, USA

At the end of this session the audience should be able to:• Rationalize the optimal use of DMSA/succimer in the treatment of lead poisoning• Use methylene blue in patients with significant methemoglobinemia and suspected

G6PD deficiency

11:50 – 12:05 Acute digoxin overdose and response to antibody (DORA study) (abstract no. 18)Betty SH Chan (1), Angela L Chiew (1), Colin B Page (2), Margaret O’Leary (3), Geoffrey K Isbister (3), Nicholas A Buckley (4)

(1) Prince of Wales Hospital, Sydney, Australia; (2) Princess Alexandra Hospital, Brisbane, Australia; (3) Calvary Mater Hospital, Newcastle, Australia; (4) University of Sydney, Sydney, Australia

12:05 – 12:20 Prevention of lethal colchicine toxicity by colchicine-specific Fab treatment in a porcine model (abstract no. 19)

Michael Eddleston (1), Adrian Thompson (1), Nicolas Fabresse (2), Jean-Claude Alvarez (2), Alain Astier (3), Rachael Gregson (1), Ibrahim Al Abdulla (4), Tim King (1), Eddie Clutton (1), Frederic J Baud (5)

(1) University of Edinburgh, Edinburgh, UK; (2) Universite Versailles Saint-Quentin, Garches, France; (3) School of Medicine Paris 12, Paris, France; (4) Micropharm Ltd, Newcastle Emlyn, UK; (5) University Paris Diderot, Assistance Publique - Hopitaux de Paris, UMR 8257, Paris, France

12:20 – 12:30 General discussion

12:30 – 14:00 Lunch and posters

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Room Montreal, Wednesday 17 May 2017 (afternoon)

Controversies in Pesticide Toxicology including Pro/Con Debate

Session chair: Michael Eddleston, Allister Vale

14:00 – 14:20 Neonicotinoid insecticides - safe for humans? Allister Vale, National Poisons Information Service (Birmingham Unit), Birmingham, UK14:20 – 14:40 Do neurobehavioral changes occur in humans as long-lasting consequences of acute poisoning with organophosphorus insecticides? Marcello Lotti, University of Padua, Padova, Italy14:40 – 15:00 Pesticides and Parkinson's disease: is there a causal link? Martin Wilks, Swiss Centre for Applied Human Toxicology, University of Basel, Switzerland15:00 – 15:45 Debate: Is glyphosate a probable human carcinogen? Chris Portier, Independent Consultant, Thun, Switzerland Danièle Court Marques, European Food Safety Authority (EFSA), Parma, Italy

At the end of this session the audience should be able to:• Describe the effects of neonicotinoid insecticide exposure in humans • Recognize the clinical conditions that may lead to neurobehavioral changes following

exposure to organophosphorus insecticides, describe confounding variables that may affect the results of tests and decide whether such changes are a cause of poisoning or its consequence

• Evaluate the strengths and limitations of the epidemiological and mechanistic evidence for a causal relationship between exposure to specific pesticides and Parkinson’s disease

• Discuss how human and animal data are used to evaluate the risks of cancer from exposure to an environmental agent, such as glyphosate

• Debate the use of weight of evidence approaches in the assessment of the toxicity, genotoxicity and carcinogenicity of chemicals in general, and pesticides in particular



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Room Singapore, Wednesday 17 May 2017 (afternoon)

Antidotes: Something Old, Something New, Something Borrowed, Something Blue (cont)

Session chair: Irma de Vries, Horst Thiermann

14:00 – 14:15 § Acute hypersensitivity reaction to Crotalidae polyvalent immune Fab (CroFab) initially presenting as galactose-alpha-1,3-galactose (alpha-gal) allergy (abstract no. 20)

Katlin Brill, Justin Rizer, Joshua King, Nathan P CharltonUniversity of Virginia, Charlottesville, US

14:15 – 14:30 Infant botulism in Italy: antidote treatment consideration from 8 years’ experience (abstract no. 21)Davide Lonati (1), Bruna Auricchio (2), Sarah Vecchio (1), Valeria M Petrolini (1), Virgilio Costanzo (3), Fabrizio Anniballi (2), Carlo A Locatelli (1)

(1) Pavia Poison Control Centre - National Toxicology Information Centre - Clinical and Experimental Lab, Toxicology Unit, Maugeri Clinical and Scientific Institutes IRCCS and University of Pavia, Pavia, Italy; (2) National Reference Centre for Botulism (NRCB), Department of Veterinary Public Health and Food Safety, National Institute of Health (ISS), Rome, Italy; (3) Ministry of Health, National Health System, Rome, Italy

14:30 – 14:45 Vipera ammodytes bites treated with antivenoms Viperfav® and ViperaTAb® (abstract no. 22)Miran Brvar (1), Tihana Kurtović (2), Damjan Grenc (1), Maja Lang Balija (2), Igor Krizaj (3), Beata Halassy (2)

(1) University Medical Centre Ljubljana, Ljubljana, Slovenia; (2) University of Zagreb, Zagreb, Croatia; (3) Jožef Stefan Institute, Ljubljana, Slovenia

14:45 – 15:00 Discontinuation of N-acetylcysteine in patients meeting certain criteria: outcomes in a retrospective review (abstract no. 23)

Christopher Hoyte (1), Shireen Banerji (2)

(1) University of Colorado School of Medicine, Aurora, US; (2) Rocky Mountain Poison and Drug Center, Denver, US

15:00 – 15:15 Fewer adverse effects with a modified 2-bag intravenous acetylcysteine protocol compared to the traditional 3-bag protocol in paracetamol overdose (abstract no. 24)

Richard McNulty (1), Elizabeth JM Lim (2), Pramodh Chandru (1), Naren Gunja (1)

(1) Western Sydney Toxicology Service, Sydney, Australia; (2) Sydney University, Sydney, Australia15:15 – 15:30 Palatability of tablets and capsule forms of N-acetylcysteine and methionine and associated adverse events in healthy volunteers (abstract no. 25)

Vindya M Pathiraja (1), Indika B Gawarammana (2), Nicholas A Buckley (3), Fahim Mohamed (3), Shaluka F Jayamanna (4), Nicholas Osborne (3), Andrew H Dawson (5)

(1) South Asian Toxicology Research Collaboration, Faculty of Medicine, University of Peradeniya, Sri Lanka; (2) Department of Medicine, Faculty of Medicine, University of Peradeniya, Sri Lanka; (3) Department of Pharmacology, School of Medical Sciences, University of Sydney, Australia; (4) Department of Medicine, University of Kelaniya, Ragama, Sri Lanka; (5) Royal Prince Alfred Clinical School, University of Sydney, Australia

15:30 – 15:45 *Efficacy of isosorbide dinitrate as an antidote in cyanide poisoning in a swine model (abstract no. 26)

Ophir Lavon (1), Arik Eisenkraft (2)

(1) Carmel Medical Center, Haifa, Israel; (2) Faculty of Medicine, Hebrew University, Jerusalem, Israel


§ Shortlisted for Taylor & Francis best case study award *ShortlistedforTaylor&Francisbestscientificpresentationaward

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MAIN CONGRESS

Room Montreal, Wednesday 17 May 2017 (afternoon)

Oral Session: Epidemiology of Poisoning

Session chair: John Thompson, Bill Banner

16:15 – 16:30 Dramatic improvement of poisoned patient survival in Southern province, Sri Lanka (abstract no. 31)

Ishari S Fernando (1), Kasun M Fernando (2), Arosha Dissanayaka (3), Rohan Ruwanpura (1)

(1) Teaching Hospital Karapitiya, Ambalangoda, Sri Lanka; (2) Base Hospital Balapitiya, Ambalangoda, Sri Lanka; (3) University of Ruhuna, Galle, Sri Lanka

16:30 – 16:45 Patients with acute chemical exposure seen in Emergency Departments (ED) in Spain: results of the Spanish Toxic Surveillance System (STSS) 2015 (abstract no. 32)

Ana Ferrer Dufol (1), Santiago Nogue Xarau (2), Francisco Ruiz Ruiz (1), Clara Serrano Ferrer (3), Agustin Garcia Urdangarin (4), Collaborators of the STSS (5)

(1) Clinical University Hospital, Zaragoza, Spain; (2) Clinic Hospital, Barcelona, Spain; (3) Medical School, Zaragoza, Spain; (4) University Documentation Service, Zaragoza, Spain; (5) FETOC, Zaragoza, Spain

16:45 – 17:00 Increases in pediatric vitamin D exposure calls to the US National Poison Data System (abstract no. 33)

Marissa Hoffman (1), Jeanette Trella (2), Kevin C Osterhoudt (2)

(1) The Children’s Hospital of Philadelphia, Philadelphia, US; (2) The Poison Control Center at The Children’s Hospital of Philadelphia, Philadelphia, US

MAIN CONGRESS

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Room Singapore, Wednesday 17 May 2017 (afternoon)

Oral Session: Poisoning Outbreaks

Session chair: Joanna Tempowski, Sergey Zakharov

16:15 – 16:30 *Elimination half-life and chronic health impairment 50 years after 2, 3, 7, 8-tetra chloro-dibenzo- p- Dioxin (TCDD) exposure (abstract no. 34)

Daniela Pelclova (1), Zdenka Fenclova (1), Stepanka Vlckova (1), Pavel Urban (1), Petr Ridzon

(1), Tomas Navratil (2), Sergey Zakharov (1) (1) First Medical Faculty, Charles University, Prague, Czech Republic; (2) H. Heyrovsky Institute of Physical Chemistry CAS v.v. i., Prague, Czech Republic

16:30 – 16:45 *National vitamin D intoxication outbreak among infants due to a manufacturing error of vitamin D droplets: challenges for the health care system (abstract no. 35)

Søren Bøgevig (1), Lotte CG Hoegberg (2), Anders J Schou (3), Ida M Schmidt (4), Fie J Vojdeman

(5), Konstantinos Kamperis (6), Christian Mølgaard (7), Christine Brot (8), Henrik Christesen (3)

(1) Department of Clinical Pharmacology, The Danish Poisons Information Center, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark; (2) Department of Anaesthesiology, The Danish Poisons Information Center, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark; (3) Hans Christian Andersen Children’s Hospital, Odense University Hospital, Odense, Denmark; (4) Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; (5) Department of Clinical Biochemistry, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark; (6) Department of Paediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark; (7) Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark; (8) Danish Health Authority, Copenhagen, Denmark

16:45 – 17:00 Dosage regimen of biperiden to treat haloperidol-induced severe facio-troncular dystonic syndrome in children (abstract no. 36)

Frederic J Baud, Nicolas Peyraud, Micaela Serafini, Annette HeinzelmannMedecins Sans Frontières, Paris, France

*ShortlistedforTaylor&Francisbestscientificpresentationaward

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Room Montreal, Thursday 18 May 2017 (morning)

Louis Roche Lecture followed by Pro/Con Debate & Paracetamol Poisoning: New Insights

Session chair: Bruno Mégarbane

08:45 – 09:00 Introduction and presentation of Louise Roche lecturer09:00 – 09:45 New psychoactive substances: a challenge and impulse for clinical toxicology Carlo Locatelli, Poison Control Centre, IRCCS Maugeri Foundation Hospital, Pavia, Italy

At the end of this lecture the audience should be able to:• Reflect on the role of poisons centers/clinical toxicologists in the dissemination of

knowledge on novel psychoactive substance (NPS) toxicity and preventive activities

Session chair: Sally Bradberry, Patricia Casey

09:45 – 10:30 Debate: Shorter course IV acetylcysteine for paracetamol poisoning – it’s time to make a SNAP decision James Dear, University of Edinburgh, UK Richard C Dart, Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, Denver, USA

At the end of this debate the audience should be able to:• Explain the benefits of using novel shorter acetylcysteine (NAC) regimens with

regard to safety and speed of treatment• Recognize the risks of premature termination of acetylcysteine treatment and how

to avoid them


Session chair: Paul Dargan, D Nicholas Bateman

11:10 – 11:30 Biomarkers for paracetamol poisoning - research tools or practical aids to the management of the poisoned patient? Nicholas A Buckley, University of Sydney, Australia

At the end of this lecture the audience should be able to:• Identify which of the new paracetamol biomarkers are (and are not) relevant to their

clinical or research work

11:30 – 11:45 *Modified release paracetamol overdose: a prospective observational study (abstract no. 111)Angela L Chiew (1), Geoffrey K Isbister (2), Colin B Page (3), Betty SH Chan (1), Nicholas A Buckley (4)

(1) Prince of Wales Hospital, Randwick, Australia; (2) University of Newcastle, Newcastle, Australia; (3) Princess Alexandra Hospital, Brisbane, Australia; (4) The Children’s Hospital, Westmead, Australia


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Room Montreal, Thursday 18 May 2017 (morning)

Paracetamol Poisoning: New Insights (cont)

11:45 – 12:00 Analysis of an abbreviated acetylcysteine infusion protocol for repeated supratherapeutic ingestion (RSTI) of paracetamol (abstract no. 112)

Anselm Wong (1), Richard McNulty (2), Naren Gunja (2), Andis Graudins (3)

(1) Austin Health, Victoria, Australia; (2) Westmead Hospital, Sydney, Australia; (3) Monash Health, Victoria, Australia

12:00 – 12:15 Review of the availability of paracetamol sold as over-the-counter drugs in European pharmacies; a descriptive cross sectional study (abstract no. 113)

Britt Morthorst (1), Annette Erlangsen (2), Merete Nordentoft (1), Keith Hawton (3), Lotte CG Hoegberg (4), Kim P Dalhoff (4)

(1) Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark; (2) Danish Research Institute for Suicide Prevention, Copenhagen, Denmark; (3) Centre for Suicide Research, Oxford University, Oxford, UK; (4) Bispebjerg and Frederiksberg University Hospital, Copenhagen, Denmark

12:15 – 12:30 Evaluation of a US Food and Drug Administration mandate to limit acetaminophen in prescription combination products (abstract no. 114)

David Goldberger, David VearrierDrexel University College of Medicine, Philadelphia, US


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MAIN CONGRESS

Room Singapore, Thursday 18 May 2017 (morning)

Toxicology of Anti-Convulsant Drugs Followed by Short Orals (2)

Session chair: Herbert Desel, Alison Good

09:50 – 10:10 Mitochondrial toxicity of antiepileptic drugs and implications for the treatment of mitochondrial epilepsy Josef Finsterer, Municipality of Vienna, Austria10:10 – 10:30 Are new anticonvulsant drugs safer than old ones? Bruno Mégarbane, Paris-Diderot University, Paris, France

At the end of this session the audience should be able to:• Assess which antiepileptic drugs (AEDs) are the most appropriate in patients with

mitochondrial disorders and epilepsy• Summarize the mechanisms of action and potential toxicity of the new anticonvulsant

drugs


Session chair: Mark Zammit, Kim Dalhoff

11:10 – 11:30 How to manage poisoning with anticonvulsants Florian Eyer, Klinikum rechts der Isar, Technical University of Munich, Germany11:30 – 11:50 Too much of a good thing: Antiepileptic toxicity Sophie Gosselin, McGill University Health Centre, Montreal, Canada

At the end of this session the audience should be able to:• Recognize that numerous anticonvulsants with different mechanisms of action exist,

resulting in distinct clinical symptoms of overdose• Recognize the clinical presentation of antiepileptic toxicity and the role for

extracorporeal therapies

11:50 A characterization of levetiracetam abuse and misuse reported to US Poison Centers through the National Poison Data System (NPDS) (abstract no. 115)

Christopher Hoyte (1,2), Shireen Banerji (2)


11:55 Acute lamotrigine overdoses treated at the department of Emergency and Clinical Toxicology during a 3-year period clinical overview (abstract no. 116)

Gordana Vuković-Ercegović (1), Nataša Perković-Vukčević (1), Olivera Potrebić (1), Vesna Mijatovic (2), Jasmina Jović-Stošič (1)

(1) Military Medical Academy, Belgrade, Serbia; (2) Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia

MAIN CONGRESS

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Room Singapore, Thursday 18 May 2017 (morning)

Short Orals (2) (cont)

12:00 Clinical features of acute carbamazepine poisoning in children: a 5-year retrospective study (abstract no. 117)

Viorela Nitescu, Dora Boghitoiu, Iolanda C Vivisenco, Alexandru Ulmeanu, Coriolan E UlmeanuPediatric Poisoning Centre, Emergency Clinical Hospital for Children “Grigore Alexandrescu”, Bucharest, Romania

12:05 Severe toxicity following lamotrigine overdose: a review of calls to Australia’s largest Poisons Information Centre (abstract no. 118)

Rose Cairns (1), Andrew H Dawson (1), Darren M Roberts (2), Nicholas A Buckley (1)

(1) The New South Wales Poisons Information Centre, The Children’s Hospital at Westmead; Sydney Medical School, The University of Sydney, Sydney, Australia; (2) The New South Wales Poisons Information Centre, The Children’s Hospital at Westmead; Renal Medicine Unit, Canberra Hospital, Canberra, Australia

12:10 Severe valproic acid poisoning associated with atrial fibrillation and extreme high serum concentrations (abstract no. 119) Csaba Pap, Peterfy Hospital, Budapest, Hungary12:15 Lamotrigine enquiries to the Austrian Poisons Information Centre: a retrospective 14 year study (abstract no. 120)

Kinga Bartecka-Mino, Helmut Schiel, Tara ArifPoisons Information Centre, Vienna, Austria

12:20 Exposures to valproic acid: a 14 year descriptive study of Austrian Poisons Information Centre data (abstract no. 121)

Tara Arif, Kinga Bartecka-Mino, Helmut SchielPoisons Information Centre, Vienna, Austria



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Room Montreal, Thursday 18 May 2017 (afternoon)

The Virtual Toxicologist: Leveraging Social Media for Toxicology Education, Outreach & Research followed by Short Oral Presentations Social Media

Session chair: Peter Chai, Davide Lonati

13:55 – 14:00 Introduction to the Mini Symposium/Introduction to Social Media Platforms Peter R Chai, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA14:00 – 14:15 Social media in toxicologic disasters Timothy B Erickson, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA14:15 – 14:30 Social Media for online education Anselm Wong, Austin Health, Melbourne, Australia14:30 – 14:45 Twitter and Facebook groups: How we can maximize our toxicology education and engage learners Matthew Griswold, University of Massachusetts Medical School, Worcester, USA Mark Neavyn, University of Massachusetts Medical School, Worcester, USA14:45 – 15:00 The National Poisons Information Centre experience in social media for outreach Niamh English, National Poisons Information Centre Ireland, Dublin, Ireland15:00 – 15:15 The Edinburgh Clinical Toxicology experience in social media Euan Sandilands, National Poisons Information Centre Edinburgh, Edinburgh, UK15:15 – 15:30 Research in drug trends, substances of abuse and self-harm on social media Edward W Boyer, Harvard Medical School, Boston, USA Alex Manini, Icahn School of Medicine at Mount Sinai, New York, USA

At the end of this mini symposium the audience should be able to:• Summarize how to use various social media platforms for toxicologists• Recognize components of Tweets that maximize impact among students of toxicology,

and describe common ethical dilemmas encountered by toxicologists using social media platforms

• Describe methods used to discover social media trends in intentional drug overdose and novel drugs of abuse

15:30 Please “like” us: Facebook as an outreach tool for a poisons information centre (abstract no. 129)

Niamh Walsh, Patricia Casey, Edel DugganNPIC Ireland, Dublin, Ireland

15:35 Linguistic differences between Spanish and English tweets that mention opioids (abstract no. 130)

Michael Chary (1), Alex F Manini (2)

(1) New York Presbyterian Queens, Peekskil, US; (2) Elmhurst Hospital Center, Elmhurst, US15:40 YouTube™ is a feasible tool to disseminate educational toxicology videoconferences: The Global Educational Toxicology Uniting Project (GETUP) (abstract no. 131)

Anselm Wong (1), Rais Vohra (2), Anne Creaton (3), Zeff Koutsogiannis (1), Shaun L Greene (1)

(1) Austin Health, Victoria, Australia; (2) Fresno Medical Center, California, US; (3) Colonial War Memorial Hospital, Suva, Fiji



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Room Singapore, Thursday 18 May 2017 (afternoon)

Experimental and Applied ResearchToxicosurveillance (including Poison Centre Activities)

Session chair: Florian Eyer, Sophie Gosselin

14:00 Comparative extractive efficiency of continuous veno-venous hemodiafiltration (CVVHDF) and molecular adsorbent recirculating system (MARS) in simulated verapamil poisoning: an ex vivo study (abstract no. 122)

Nicolas Caill (1), Frederic J Baud (2), Romain Jouffroy (2), Jean-Claude Alvarez (3), Lionel Lamhaut (4)

(1) Assistance Publique-Hopitaux de Paris, Paris, France; (2) Assistance Publique-Hopitaux de Paris; University Paris Diderot, Paris, France; (3) AP-HP; University VSQ, Paris, France; (4) AP-HP; University Paris Descartes, Paris, France

14:15 Leukotriene-mediated neuroinflammation and toxic brain damage in methanol poisoning (abstract no. 123)

Sergey Zakharov (1), Katerina Kotikova (2), Olga Nurieva (2), Petr Kacer (3), Tomas Navratil

(4), Daniela Pelclova (2)

(1) First Faculty of Medicine, Charles University, Department of Occupational Medicine; Toxicological Information Centre, General University Hospital, Prague, Czech Republic; (2)

First Faculty of Medicine, Charles University, Department of Occupational Medicine, Prague, Czech Republic; (3) Institute of Chemical Technology, Prague, Czech Republic; (4) Department of Biomimetic Electrochemistry, J. Heyrovský Institute of Physical Chemistry of the AS CR, v.v.i, Prague, Czech Republic

14:30 Transient receptor potential (TRP) channels as therapeutic targets in toxic lung injury (abstract no. 124)

Dirk Steinritz (1), Thomas Gudermann (2), Tanja Popp (1), Alexander Dietrich (2), Bernhard Stenger (2), Horst Thiermann (1)

(1) Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany; (2)

Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilian-University Munich, Munich, Germany

14:45 Pharmacogenetics of 3,4-methylenedioxymethamphetamine (MDMA): cytochrome P450 polymorphisms moderate pharmacokinetics and pharmacodynamic effects of MDMA in healthy subjects (abstract no. 125)

Patrick Vizeli, Yasmin Schmid, Matthias E LiechtiUniversitätsspital Basel, Basel, Switzerland

15:00 Age of misuse exposures reported by the Global Toxicosurveillance Network (GTNet) (abstract no. 126)

Laura J Fischer (1), Zachary R Margolin (1), Jody L Green (1), Bruno Megarbane (2), Antoine Villa (2), Andreas Schaper (3), Martin Ebbecke (3), Fabrizio Sesana (4), Simon HL Thomas (5), John P Thompson (6)

(1) Rocky Mountain Poison & Drug Center, Denver Health, Denver, US; (2) Centre Antipoison et de Toxicovigilance de Paris, Paris, France; (3) GIZ-Nord Poisons Centre, University Medical Center, Göttingen, Germany; (4) Poison Control Centre of Milan, Milan, Italy; (5) National Poisons Information Service, Newcastle, UK; (6) National Poisons Information Service, Cardiff, UK

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Toxicosurveillance (including Poison Centre Activities) (cont)

15:15 *Using Swedish Poisons Information Centre data to identify chemical accident hazards at the workplace (abstract no. 127)

Anita Annas (1), Karin Feychting (1), Mattias Öberg (2), Linda Schenk (2)

(1) Swedish Poisons Information Centre, Stockholm, Sweden; (2) Institute of Environmental Medicine, Stockholm, Sweden

15:30 Utilisation of desferrioxamine in iron poisoning: experience of the UK National Poisons Information Service (NPIS) 2014-2016 (abstract no. 128)

Victoria A Eagling (1), Euan A Sandilands (1), Leonard C Hawkins (2), Gillian A Cooper (3), Ted T Cheung (4), Simon HL Thomas (2), John P Thompson (3), J Allister Vale (4), Michael Eddleston

(5), D Nicholas Bateman (6)

(1) Royal Infirmary of Edinburgh, Edinburgh, UK; (2) Regional Drug and Therapeutics Centre, Newcastle, UK; (3) University Hospital Llandough, Cardiff, UK; (4) City Hospital, Birmingham, UK; (5) Royal Infirmary of Edinburgh / University of Edinburgh, Edinburgh, UK; (6) University of Edinburgh, Edinburgh, UK



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Room Montreal, Thursday 18 May 2017 (afternoon)

The Virtual Toxicologist: Leveraging Social Media for Toxicology Education, Outreach & Research (cont)

Session chair: Hugo Kupferschmidt, Peter Hultén

16:15 – 16:45 Round Table on Social Media Mark Neavyn, UMass Memorial Center, Worcester, USA (moderator) Katharine Boyle, Beth Israel Deaconess Medical Center, Boston, USA Peter R Chai, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA Niamh English, National Poisons Information Centre Ireland, Dublin, Ireland Timothy Erickson, Brigham and Women’s Hospital, Boston, USA Euan Sandilands, National Poisons Information Centre Edinburgh, UK

17:00 – 18:30 EAPCCT General Assembly


Novel Psychoactive Substances

Session chair: Edward Krenzelok, David Wood

16:15 – 16:30 *Toxicity associated with the use of α-PVP (α-pyrrolidinovalerophenone): a case series of 417 patients presenting to a regional poisons treatment centre (abstract no. 136)

Konstantin Brusin (1), Yulia V Kraeva (2), Maria A Gofenberg (2), David M Wood (3), Paul I Dargan (4)

(1) Kaplan Medical Centre, Rehovot, Israel; (2) Sverdlovsk Regional Psychiatric Hospital, Yekaterinburg, Russian Federation; (3) Guy’s and St Thomas NHS Foundation Trust, London, UK; (4) Guy’s and St Thomas’ NHS Foundation Trust and King’s Health Partners, London, UK

16:30 – 16:45 § Severe cardiovascular toxicity, cerebral hemorrhage and mortality after using 4-fluoroamphetamine (4-FA) (abstract no. 137)

Johanna J Nugteren-Van Lonkhuyzen, Antoinette JHP Van Riel, Irma de Vries, Saskia J Rietjens, Laura HondebrinkUniversity Medical Center Utrecht (UMCU), Utrecht, The Netherlands

16:45 – 17:00 *Rhabdomyolysis induced by psychoactive substances: an analysis of EuroDEN data (abstract no. 138)

Wojciech Waldman (1), Jacek Sein Anand (1), Piotr M Kabata (2), Alison M Dines (3), David M Wood (3), Christopher Yates (4), Fridtjof Heyerdahl (5), Knut Erik Hovda (5), Isabelle Giraudon

(6), On behalf of Euro- DEN Research Group (7), Paul I Dargan (3)

(1) Medical University of Gdansk, Gdańsk, Poland; (2) Pomeranian Centre of Toxicology, Gdańsk, Poland; (3) Guy’s and St Thomas’ NHS Foundation Trust and King’s Health Partners, London, UK; (4) Hospital Universitari Son Espases, Mallorca, Spain; (5) Medical Division, Oslo University Hospital, Oslo, Norway; (6) European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Lisbon, Portugal; (7) Euro-DEN Research Group

§ Shortlisted for Taylor & Francis best case study award *ShortlistedforTaylor&Francisbestscientificpresentationaward

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Room Montreal, Friday 19 May 2017 (morning)

Young Investigator Award (YIA)

Session chair: Robert Palmer, Simon Thomas

08:45 – 08:50 Introduction08:50 – 09:05 Mechanistic biomarkers stratify patients after paracetamol overdose with high sensitivity and specificity (abstract no. 220)

James W Dear (1), Joanna I Clarke (2), Ben Francis (2), Lowri Philips (1), Jonathan Wraight

(1), Paul I Dargan (3), David M Wood (3), Jamie Cooper (4), Simon HL Thomas (5), Andrea Jorgensen (2), Munir Pirmohamed (2), B. Kevin Park (2), Daniel J Antoine (2)

(1) University of Edinburgh, Edinburgh, UK; (2) University of Liverpool, Liverpool, UK; (3)

Guy’s and St Thomas’ NHS Foundation Trust, London, UK; (4) Aberdeen Royal Infirmary, Aberdeen, UK; (5) Newcastle University, Newcastle, UK

09:05 – 09:20 Ciguatoxin-induced chronic disease unmasks people carrying human leukocyte antigen (HLA) epitopes peculiar to celiac disease and rheumatoid arthritis (abstract no. 221)

Azzurra Schicchi (1), Annamaria Pasi (2), Davide Lonati (1), Teresa Coccini (1), Carlo A Locatelli (1), Miriam Martinetti (2)

(1) Pavia Poison Control Centre - National Toxicology Information Centre - Clinical and Experimental Lab, Toxicology Unit, Maugeri Clinical and Scientific Institutes IRCCS and University of Pavia, Pavia, Italy; (2) Department of Hematology, IRCCS Policlinico S. Matteo Foundation, University of Pavia, Pavia, Italy

09:20 – 09:35 Imaging drug-drug interaction using positron emission tomography (PET) scans: investigating the impact of diazepam on buprenorphine-induced respiratory depression (abstract no. 222)

Nicolas Tournier (1), Dominique Vodovar (2), Geraldine Pottier (1), Sylvain Auvity (1), Bruno Megarbane (3), Irène Buvat (1), Fabien Caille (1)

(1) IMIV, CEA, Inserm, CNRS, Paris-Sud & Paris-Saclay Universities, Orsay, France; (2) INSERM UMRS-1144, Paris-Descartes & Paris-Diderot Universities, Paris, France; (3) Department of Medical and Toxicological Critical Care, Lariboisière Hospital, Paris, France

09:35 – 09:50 Utility of QT interval corrected by the Rautaharju method to predict drug-induced torsades de pointes (abstract no. 223)

Rittirak Othong (1), Suttisak Wattanasansomboon (1), Thanakorn Kruutsaha (1), Douglas Chesson (2), Ziad Kazzi (2)

(1) Vajira Hospital, Bangkok, Thailand; (2) Emory University, Atlanta, US09:50 Judging commences09:50 – 10:05 Lucy in the Sky with Diamonds or LSD: Past, Present and Future Matthias Liechti, University Hospital Basel, Switzerland10:05 – 10:20 Paracelsus in Basel Martin Wilks, Swiss Centre for Applied Human Toxicology, University of Basel, Switzerland

At this end of these lectures the audience should be able to:• Describe the role of Basel in the detection and past and present research on LSD• Discuss Paracelsus’ time as city physician in Basel in 1527/28 and his approach to the

use of ‘poisons’ as therapeutics

10:20 – 10:30 Presentation to the winner of the YIA


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Room Montreal, Friday 19 May 2017 (morning)

Biomarkers, Clinical Toxicology and Translational Medicine (APAMT Symposium at EAPCCT)

Session chair: Jou-Fang Deng, Charles McKay

11:10 – 11:30 Regulatory toxicology: are biomarkers the missing link? Darren Roberts, St Vincent's Hospital, Sydney, Australia and Medical School, Australian National University, Canberra, Australia11:30 – 11:50 Use of biomarkers in laboratory-models of toxicity Klintean Wunnapuk, Chiang Mai University, Chiang Mai, Thailand 11:50 – 12:10 Biomarkers of kidney injury: clinical research generates both questions and answers Fahim Mohammed, SACTRC, University of Peradeniya, Sri Lanka12:10 – 12:30 Biomarkers in snake envenomation: local data prompts broad applications Anjana Silva, Monash Venom Group, Monash University, Clayton, Australia and Rajarata University of Sri Lanka, Saliyapura, Sri Lanka

At the end of this session the audience should be able to:• Describe the limitations of existing criteria used by regulatory agencies and

opportunities for newer approaches based on biomarkers • Explain how to use pre-clinical animal models in pesticide toxicology research and

how they relate to clinical practice• Summarize examples of the variability in currently used biomarkers on the apparent

severity of nephrotoxicity following poisoning • Describe the relevance of different biomarkers of snake envenoming to the clinical

management of the patient


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Room Singapore, Friday 19 May 2017 (morning)

Short Orals (3)

Session chair: Nicolas Buckley, Thomas Zilker

11:10 QT prolongation in opioid poisoning is mostly due to methadone (abstract no. 230)Gopi Mann (1), Naren Gunja (2)

(1) NSW Poisons Information Centre, Sydney, Australia; (2) Discipline of Emergency Medicine, Sydney Medical School, Sydney, Australia

11:15 Comparison of self-reported recreational substance use with immunoassay and liquid chromatography mass spectrometry findings in cases with acute recreational drug toxicity (abstract no. 231)

Evangelia Liakoni, Patrick C Dolder, Katharina M Rentsch, Matthias E LiechtiUniversity Hospital Basel and University of Basel, Basel, Switzerland

11:20 Prognostic utility of initial lactate for Emergency Department (ED) drug overdose fatality: a validation cohort (abstract no. 232)

Randy Cheung (1), Robert S Hoffman (2), David Vlahov (3), Alex F Manini (4)

(1) State University of New York, Buffalo, US; (2) NYU School of Medicine, New York, US; (3) University of California at San Francisco, San Francisco, US; (4) The Icahn School of Medicine at Mount Sinai, New York, US

11:25 Does targeted temperature management improve hospital survival for presumed drug overdose-related cardiac arrest? (abstract no. 233)

Sharaf Khan (1), Chad Meyers (2), Suzanne Bentley (2), Yanoh Jalloh (1), Alex F Manini (2)

(1) The Icahn School of Medicine at Mount Sinai, New York, US; (2) The Icahn School of Medicine at Mount Sinai, Elmhurst Hospital Center, New York, US

11:30 Pharmacokinetics and pharmacodynamics of two doses of oral LSD in healthy subjects (abstract no. 234)

Matthias E Liechti, Yasmin Schmid, Katharina M Rentsch, Felix Hammann, Patrick C DolderUniversity Hospital Basel, Basel, Switzerland

11:35 Relationship between poison center opioid exposure data and mortality rates and National Vital Statistics System mortality rates (abstract no. 235)

Janetta L Iwanicki, Zachary R Margolin, Stevan G Severtson, Richard C DartRocky Mountain Poison and Drug Center, Denver, US

11:40 Tramadol poisoning in the intensive care unit: clinical presentation and prognostic value of plasma tramadol concentration on admission (abstract no. 236)

Christophe Camillerapp (1), Laurence Labat (2), Marion Soichot (3), Isabelle Malissin (1), Pierre Garçon (1), Antoine Goury (1), Lamia Kerdjana (1), Sebastian Voicu (1), Nicolas Deye (1), Bruno Mégarbane (1) (1) Department of Medical and Toxicological Critical Care, Lariboisière Hospital, Paris, France; (2) Laboratory of Toxicology, Cochin Hospital, Paris, France; (3) Laboratory of Toxicology, Lariboisière Hospital, Paris, France

11:45 Pack size restriction of mild analgesics sold as over-the-counter drugs in pharmacies in Denmark: preliminary register findings (abstract no. 237)

Britt Morthorst (1), Annette Erlangsen (2), Keith Hawton (3), Kim P Dalhoff (4), Merete Nordentoft (1)

(1) Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark; (2) Danish Research Institute for Suicide Prevention, Copenhagen, Denmark; (3) Centre for Suicide Research, Oxford University, Oxford, UK; (4) Bispebjerg and Frederiksberg University Hospital, Copenhagen

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Room Singapore, Friday 19 May 2017 (morning)

Short Orals (3) (cont) & Education and Outreach

11:50 Seasonality in intentional drug intake by adolescents (abstract no. 238) Arjen Koppen, Claudine C Hunault, Irma de VriesDutch Poison Information Center, Utrecht, The Netherlands

11:55 Caustic ingestion in children: experience of a Pediatric Emergency Department in Rome (abstract no. 239)

Marco Marano, Francesco P Rossi, Antonino Reale, Mara Pisani, Corrado Cecchetti, Matteo Di Nardo, Valentina A Ferro, Umberto Raucci, Daniela Perrotta, Luigi Dall’Oglio, Filippo Torroni, Paola De Angelis, Tamara Caldaro, Leonardo Genuini, Nicola PirozziOspedale Pediatrico Bambino Gesù, Rome, Italy

12:00 Drug-facilitated crimes (DFC): four years of admission in a French emergency medico- legal center specializing in victims of assaults (abstract no. 240)

Emilie Christin (1), Cecile Richeton (1), Regis Bedry (1), Nathalie Grosleron (1), Jean Hiquet (1), Veronique Dumestre-Toulet (2), Sophie Gromb-Monnoyeur (1)

(1) University Hospital Pellegrin, Bordeaux, France; (2) TOXGEN Lab, Bordeaux, France12:05 Severe poisonings and their outcomes reported to the National Poisons Information Service (NPIS), 2008-2015 (abstract no. 241)

Stephen SD Jones (1), John P Thompson (1), Sally M Bradberry (2), Euan A Sandilands (3), Simon HL Thomas (4)

(1) UK National Poisons Information Service, Cardiff, UK; (2) UK National Poisons Information Service, Birmingham, UK; (3) UK National Poisons Information Service, Edinburgh, UK; (4) UK National Poisons Information Service, Newcastle, UK

12:10 Emergency Department presentations with illicit drugs associated with problematic drug use (iPDU) toxicity are not commonly associated with co-use of new psychoactive substances (NPS) (abstract no. 242)

Luke C De La Rue (1), David M Wood (1), Alison M Dines (1), Knut Erik Hovda (2), Fridtjof Heyerdahl (2), Christopher Yates (3), Isabelle Giraudon (4), Paul I Dargan (1), Euro-DEN Plus Research Group (1)

(1) Guy’s and St Thomas’ NHS Foundation Trust and King’s Health Partners, London, UK; (2) Oslo University Hospital, Oslo, Norway; (3) Hospital Universitari Son Espases, Mallorca, Spain; (4) European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Lisbon, Portugal

12:15-12:30 Impact of online toxicology training on health professionals: the Global Educational oxicology Uniting Project (GETUP) (abstract no. 243)

Anselm Wong (1), Andrew Stolbach (2), Andrew H Dawson (3), Rais Vohra (4)

(1) Austin Health, Victoria, Australia; (2) Johns Hopkins University, Baltimore, US; (3) Royal Prince Alfred Hospital, Sydney, Australia; (4) UCSF Fresno Medical Center, California, US

12:30–14:00 Lunch and posters

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Room Montreal, Friday 19 May 2017 (afternoon)

Pre-hospital Management of Poisonings

Session chair: Miran Brvar, Dabor Résière

14:00 – 14:20 In the urban area of a developed country: the Oslo experience Odd Martin Vallersnes, Oslo Accident and Emergency Outpatient Clinic, Oslo, Norway14:20 – 14:40 In the rural area of a developing country: the Bangladesh experience Fazle Rabbi Chowdhury, Nuffield Department of Medicine, University of Oxford, UK14:40 – 15:00 On the way to hospital with the paramedics: the US experience Alex Manini, The Icahn School of Medicine at Mount Sinai, New York, USA15:00 – 15:20 On the scene by a physician-manned emergency medical service: the French SAMU experience Vincent Danel, Centre Hospitalier Universitaire, Grenoble, France15:20 – 15:40 With long-distance transport: the Australian experience Shaun Greene, Victorian Poisons Information Centre, Austin Toxicology Service, Melbourne, Australia

At the end of this session the audience should be able to:• Describe a systematic procedure for the clinical assessment and management of

patients with acute recreational drug toxicity• Identify the limitations remaining in developing countries in terms of pre-hospital

management of poisonings• Describe prehospital management of poisoning in the US• Summarize the organization of prehospital care in France and the complementary

roles of medical teams, fire brigades and private ambulances with reference to specific treatments and antidotes that can be given on scene

• Describe the unique challenges and solutions of providing pre-hospital care to poisoned patients in Australia



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Room Singapore, Friday 19 May 2017 (afternoon)

Education and Outreach (cont)Best Paper SessionSpecial Session

Session chair: Régis Bédry, Geert Verstegen

14:00 – 14:20 Sliding drugs: a co-production by a Poison Centre and School of Cinema for preventing NPS use by teenagers (abstract no. 244)

Carlo A Locatelli (1), Giulia Scaravaggi (1), Eleonora Buscaglia (1), Davide Lonati (1), Sarah Vecchio (1), Valeria M Petrolini (1), Marta Crevani (1), Azzurra Schicchi (1), Mara Garbi (1), Germano Monetti (2), Fabio Cottichelli (2), Diego Cassani (2)

(1) Pavia Poison Control Centre - National Toxicology Information Centre - Clinical and Experimental Lab, Toxicology Unit, Maugeri Clinical and Scientific Institutes IRCCS and University of Pavia, Pavia, Italy; (2) Civic School of Cinema “Luchino Visconti” of Milan, Milan, Italy

14:20 – 15:20 Best Paper sessionAn international panel have each been asked to select a clinical toxicology paper published in 2016 that they consider to be among the best. The aim is to highlight papers that have changed or challenged clinical practice, taught something new or unexpected, improved understanding of toxicological mechanisms, or inspired the panellists. The speakers will defend their choice in a brief 10 minute presentation followed by discussion.

Discussants: Nicholas A Buckley

Plasma paracetamol concentration at hospital presentation has a dose-dependent relationship with liver injury despite prompt treatment with intravenous acetylcysteineDavid G. Cairney, Hannah K. S. Beckwith, Khalid Al-Hourani, Michael Eddleston, D. Nicholas Bateman & James W. Dear Clinical Toxicology (2016): 54:5, 405-410.Robert PalmerInterpretation of postmortem vitreous concentrations of sodium and chlorideB. Zilg, K. Alkass, S. Berg, H. Druid Forensic Science International 2016: 263:107–113.Mark ZammitHealthcare professionals are less confident in managing acute toxicity related to the use of new psychoactive substances (NPS) compared with classical recreational drugs. Wood DM, Ceronie B, Dargan PIQJM 2016: 109(8):527-9.

15:20 – 15:40 Special session Polonium-210 poisoning: a first-hand account Paul Dargan, Guy's and St Thomas' NHS Foundation Trust, London, UK

At the end of this lecture the audience should be able to:• Summarize the lessons learnt from well-publicized case of polonium-210 poisoning


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Room Montreal, Friday 19 May 2017 (afternoon)

Pre-hospital Management of Poisonings (cont)

Session chair: Nicola Bates, Frederic Baud

16:15 – 16:30 *Reductions in emergency department referrals from primary care after use of the UK National Poisons Information Service (abstract no. 249)

Muhammad EMO Elamin (1), David A James (1), Peter Holmes (1), Gillian Jackson (2), John P Thompson (3), Euan A Sandilands (2), Sally M Bradberry (4), Simon HL Thomas (1)

(1) NPIS Newcastle, Regional Drug and Therapeutics Centre, Newcastle upon Tyne, UK; (2) NPIS Edinburgh, Scottish Poisons Information Bureau, Edinburgh, UK; (3) NPIS Cardiff, University Hospital Llandough, Cardiff, UK; (4) NPIS Birmingham, City Hospital, Birmingham, UK

16:30 – 16:45 Venlafaxine poisoning in the intensive care unit: clinical presentation and role of the cytochrome P450 2D6 phenotype in the onset of cardiovascular complications (abstract no. 250)

David Ambroise (1), Marie-Anne Loriot (2), Isabelle Malissin (1), Lucie Chevillard (3), Marion Soichot (4), Emmanuel Bourgogne (4), Bruno Mégarbane (1)

(1) Department of Medical and Toxicological Critical Care, Lariboisière Hospital, Paris, France; (2) Department of Biochemistry, HEGP, Paris, France; (3) INSERM UMRS-1144, Paris-Descartes & Paris-Diderot Universities, Paris, France; (4) Laboratory of Toxicology, Lariboisière Hospital, Paris, France

16:45 – 17:00 Baclofen poisoning in the intensive care unit: clinical features and investigation of the relationships between toxic encephalopathy and the plasma baclofen concentration (abstract no. 251)

Lucie Chevillard (1), Souaad Farah (2), Laurence Labat (3), Helène Amiel-Nieman (2), Isabelle Malissin (2), Nathalie Kubis (2), Xavier Declèves (3), Bruno Mégarbane (1-3)

(1) INSERM UMRS-1144 Paris-Descartes University, Paris, France; (2) Lariboisière Hospital, Paris, France; (3) Cochin Hospital, Paris, France


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Room Singapore, Friday 19 May 2017 (afternoon)

Natural Toxins

Session chair: Andis Graudins, Emilio Salgado

16:15 – 16:30 Myanmar Snakebite Project: analysis of the first 627 prospective cases (abstract no. 252) Julian White (1), Sam Alfred (2), Chen Au Peh (2), David Warrell (3), David Bates (1), Afzal Mahmood (4), Myat Myat Thein (5), Su Synt Synt San (5), Khin Thida Thwin (6)

(1) Women’s and Children’s Hospital, North Adelaide, Australia; (2) Royal Adelaide Hospital, Adelaide, Australia; (3) University of Oxford, Oxford, UK; (4) University of Adelaide, Adelaide, Australia; (5) Mandalay General Hospital, Mandalay, Myanmar; (6)

Yangon Specialist Hospital, Yangon, Myanmar16:30 – 16:45 Mushroom poisonings in the Slovak Republic: a 20-year retrospective analysis (abstract no. 253)

Silvia Plackova (1), Blazena Caganova (1), Olga Otrubova (1), Jaroslav Kresanek (2), Igor Batora (1)

(1) National Toxicological Information Centre, Department of Occupational Medicine and Toxicology, University Hospital Bratislava and Faculty of Medicine Comenius University, Bratislava, Slovakia; (2) Slovak Medical University, Bratislava, Slovakia

16:45 – 17:00 Molecular and toxicological study of Italian Viper venom neurotoxicity (abstract no. 254)Marco Pirazzini (1), Giulia Zanetti (1), Cesare Montecucco (2), Carlo A Locatelli (3), Davide Lonati (3), Ornella Rossetto (1)

(1) Department of Biomedical Sciences, University of Padova, Padova, Italy; (2) National Research Council Institute of Neuroscience, Padova, Italy; (3) Pavia Poison Control Center - National Toxicology Information Centre, Toxicology Unit, Maugeri Clinical and Scientific Institutes IRCCS and University of Pavia, Pavia, Italy

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ELECTRONIC POSTERS ELECTRONIC POSTERS

WEDNESDAY 17 MAY 2017 (morning) 10:30 – 11:10Session chair: Davide Lonati

1. Deltamethrin poisoning in two children following treatment of head lice with a veterinary product (abstract no. 1)Galina N Bashinskaya (1), Yury N Ostapenko (2), Gulbanu S Sadykova (3), Saltanat T Tulegenova (3), Kuandyk A Amrekulov (3)

(1) Municipal Hospital No 1, Astana, Kazakhstan; (2) Research and Applied Toxicology Center of Federal Medical and Biological Agency, Moscow, Russian Federation; (3) Municipal Pediatric Hospital, Taraz, Kazakhstan

2. Polyneuropathy following fenitrothion poisoning (abstract no. 2)Kyoung Ho ChoiUijeonbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

3. Deltamethrin acute poisoning by intravenous injection (abstract no. 3)Isabel Sanjoaquín Conde (1), Laura Sanchez Blasco (2), Antonio Güemes Sanchez (2), Ana Ferrer Dufol (3)

(1) Infectious Disease Service, Clinical University Hospital, Zaragoza, Spain; (2) Surgery Service, Clinical University Hospital, Zaragoza, Spain; (3) Unit of Clinical Toxicology, Clinical University Hospital, Zaragoza, Spain

4. Toxicity indicator value of plasma pseudocholinesterase in hepatic patients (abstract no. 4)Ahmed R Ragab Ali, Fawaz Al-MousaToxicology Consultant, Riyadah, Saudi Arabia

5. Delayed and fatal toxicity of chlorfenapyr (abstract no. 6)Chun-Chi Lin (1), Chen-Chang Yang (2)

(1) National Yang-Ming University Hospital, I-Lan, Taiwan; (2) National Yang-Ming University, Taipei, Taiwan

WEDNESDAY 17 MAY 2017 (afternoon) 15:45 – 16:15Session chair: Ana Ferrer Dufol

1. Risk factors for mortality after caustic ingestion (abstract no. 27)Blažena Cagáňová (1), Silvia Plačková (1), Tatiana Foltánová (2), Katerina Plachá (1), Erik Puchoň (2), Elena Ondriašová (2), Igor Batora (1)

(1) National Toxicological Information Centre, Department of Occupational Medicine and Toxicology, University Hospital Bratislava and Faculty of Medicine Comenius University, Bratislava, Slovakia; (2) Faculty of Pharmacy, Comenius University, Bratislava, Slovakia

2. Soap bars oral poisoning: are patients with dementia at risk? (abstract no. 29)Simon De Pralormo, Marion Brunet, Armelle Marquis, Gaël Le Roux, Marie Bretaudeau DeguigneCHU d’Angers, Angers, France

3. Unusual administration route of an antiparasitic product: a case report (abstract no. 30)Radu C Tincu, Cristian S Cobilinschi, Radu A MacoveiCarol Davila University, Bucharest, Romania

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THURSDAY 18 MAY 2017 (morning) 10:30 – 11:10Session chair: Christopher Yates

1. Life-threatening 3,4-methylenedioxy-methamphetamine (MDMA) poisoning: clinical features and prognostic value of MDMA and its major metabolite concentrations on admission (abstract no. 105)Taissa Zavgorodniaia (1), Marion Soichot (2), Sebastian Voicu (1), Isabelle Malissin (1), Antoine Goury (1), Lamia Kerdjana (1), Pierre Garçon (1), Nicolas Deye (1), Emmanuel Bourgogne (2), Bruno Mégarbane (1)

(1) Department of Medical and Toxicological Critical Care, Lariboisière Hospital, Paris, France; (2) Laboratory of Toxicology, Lariboisière Hospital, Paris, France

2. Cathinones, and in particular mephedrone, remain the biggest novel psychoactive substance (NPS) associated with acute harm and Emergency Department presentations in Europe (abstract no. 106)David M Wood (1), Alison M Dines (1), Knut Erik Hovda (2), Fridtjof Heyerdahl (2), Christopher Yates (3), Isabelle Giraudon (4), Paul I Dargan (5), Euro-DEN Plus Research Group (1)

(1) Guy’s and St Thomas’ NHS Foundation Trust London, UK; (2) Oslo University Hospital, Oslo, Norway; (3)

Hospital Universitari Son Espases, Mallorca, Spain; (4) European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Lisbon, Portugal; (5) Guy’s and St Thomas’ NHS Foundation Trust, London, UK

3. Emergence of fentanyls on the Swedish novel psychoactive substance market: analytically confirmed intoxications from the STRIDA project (abstract no. 107)Matilda Bäckberg (1), Niklas Johansson (2), Olof Beck (2), Anders Helander (2)

(1) Swedish Poisons Information Centre, Stockholm, Sweden; (2) Karolinska Institutet and Karolinska University Laboratory, Stockholm, Sweden

4. Synthetic cannabinoid receptors agonists (SCRA) toxicity associated with reduced level of consciousness: an analytically confirmed case series (abstract no. 108)Matthew S Blundell (1), Paul I Dargan (1), John RH Archer (1), Simon Hudson (2), Alison M Dines (1), Elizabeth Biswell (1), David M Wood (1)

(1) Guy’s and St. Thomas’ NHS Foundation Trust, London, UK; (2) LGC Group, Fordham, UK

5. Trends in the surveillance of mephedrone, MDMA and cocaine detected in anonymous pooled street urine samples: is mephedrone use decreasing in the UK? (abstract no. 109)John RH Archer (1), Simon Hudson (2), Rachelle Abouchedid (3), James Ho (3), David M Wood (1), Paul I Dargan (1)

(1) Clinical Toxicology, Guy’s and St Thomas’ NHS Foundation Trust and King’s Health Partner’s and Faculty of Life Sciences and Medicine, King’s College London, London, UK; (2) LGC Health Sciences, Fordham, UK; (3) Clinical Toxicology, Guy’s and St Thomas’ NHS Foundation Trust and King’s Health Partners, London, UK

6. Marijuana and synthetic cannabinoid patterns in a US state with legalized marijuana: a 5-year NPDS review (abstract no. 110)Shireen Banerji (1), Christopher Hoyte (1,2)

(1) Rocky Mountain Poison Center, Denver, US; (2) University of Colorado School of Medicine, Aurora, US

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THURSDAY 18 MAY 2017 (afternoon) 15:45 – 16:15Session chair: Peter Hultén

1. § Analytically confirmed post-injection delirium/sedation syndrome (PDSS) after olanzapine long-acting injection (abstract no. 132)Valeria M Petrolini (1), Giulia Scaravaggi (1), Eleonora Buscaglia (1), Concettina Lambiase (2), Maddalena Carbone

(2), Elisa Roda (1), Teresa Coccini (1), Carlo A Locatelli (1)

(1) Pavia Poison Control Center - National Toxicology Information Centre, Clinical and Experimental Lab, Toxicology Unit, Maugeri Clinical and Scientific Institutes IRCCS and University of Pavia, Pavia, Italy; (2) Servizio di Anestesia e Rianimazione, Azienda Ospedaliera Regionale, San Carlo, Potenza, Italy

2. Incidence and risk factors for hyperlactatemia in patients with metformin overdose (abstract no. 133)Emily S Taub (1), Robert S Hoffman (2), Alex F Manini (3)

(1) Emergency Medicine Residency, The Icahn School of Medicine at Mount Sinai, New York, US; (2) NYU School of Medicine, New York, US; (3) The Icahn School of Medicine at Mount Sinai, New York, US

3. Paracetamol-protein adducts following modified release paracetamol overdose (abstract no. 134)Angela L Chiew (1), Laura P James (2), Lynda G Letzig (2), Geoffrey K Isbister (3), Nicholas A Buckley (1) (1) University of Sydney, Sydney, Australia; (2) Arkansas Children’s Hospital and University of Arkansas for Medical Sciences, Little Rock, US; (3) University of Newcastle, Newcastle, Australia

4. Survival after varenicline and phentermine overdose with documented serum blood concentrations (abstract no. 135)James Barton (1), Anselm Wong (2), Dimitri Gerostamoulos (3), Kerryn Crump (3), Andis Graudins (1)

(1) Monash Health, Victoria, Australia; (2) Austin Health, Victoria, Australia; (3) Victorian Institute of Forensic Medicine, Victoria, Australia

FRIDAY 19 MAY 2017 (morning) 10:30 – 11:10Session chair: Paul Dargan

1. The role of expert identification of spiders in the correct management of spider bites: a pilot study from Pavia Poison Control Centre (abstract no. 224)Marta Crevani (1), Carlo M Legittimo (2), Mara Garbi (1), Enrico Simeon (2), Davide Lonati (1), Sarah Vecchio (1), Carlo A Locatelli (1)

(1) Pavia Poison Control Centre - National Toxicology Information Centre - Clinical and Experimental Lab, Toxicology Unit, Maugeri Clinical and Scientific Institutes IRCCS and University of Pavia, Pavia, Italy; (2)

Aracnofilia – Italian Association of Arachnology, Cervignano del Friuli, Udine, Italy

2. Spider bite: a rare case of cutaneous loxoscelism in the west of Iran (abstract no. 225)Ahmad Ghoochani Khorasani (1), Zahra Fakherdanesh (2)

(1) Valiasr Hospital, Amin Police University, Islamic Republic of Iran; (2) Valiasr Hospital, Tehran University of Medical Sciences, Islamic Republic of Iran

3. A case of Fallopia multiflora-induced hepatotoxicity treated with acetylcysteine (abstract no. 226)Yit H Leang, Anselm Wong, Shaun L GreeneAustin Health, Victoria, Australia


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FRIDAY 19 MAY 2017 (morning) (cont) 10:30 – 11:10 4. Cardiotoxic hyperkalemia as a result of canary seed ingestion (abstract no. 227)Emily S Taub, Ruben E OlmedoThe Icahn School of Medicine at Mount Sinai, New York, US

5. French health national survey on poisoning by mushrooms (abstract no. 228)Chloe Bruneau (1), Nathalie Frebet (1), Sandra Sinno-Tellier (2), Marion Brunet (1), Corinne Schmitt (3), Corinne Pulce (4), Noël Amouroux (5), Arnaud Courtois (6), Patrick Nisse (7), Antoine Villa (8), Elisabeth Gomes (9), Nadia Ihadadene (10), Anne Landreau (11), Gaël Le Roux (1)

(1) CHU d’Angers, Angers, France; (2) Sante Publique France, Paris, France; (3) APHM, Marseille, France; (4) CHU de Lyon, Lyon, France; (5) CHU de Toulouse, Toulouse, France; (6) CHU de Bordeaux, Bordeaux, France; (7) CHU de Lille, Lille, France; (8) APHP, Paris, France; (9) CHU de Nancy, Nancy, France; (10) CHU de Strasbourg, Strasbourg, France; (11) Universite d’Angers, Angers, France

6. Role of superoxide dismutase in severe mushroom poisoning: a case report (abstract no. 229)Radu C Tincu, Cristian S Cobilinschi, Radu A MacoveiCarol Davila University, Bucharest, Romania

FRIDAY 19 MAY 2017 (afternoon) 15:45 – 16:15Session chair: Mark Zammit

1. Can duration of hemodialysis be estimated based on the on-arrival laboratory tests and clinical manifestations in methanol-poisoned patients? (abstract no. 245)Abdolkarim Pajoumand, Nasim Zamani, Hossein Hassanian-Moghaddam, Shahin ShadniaShahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran

2. Emergency anesthetic management of dapsone-induced methemoglobinemia: a case report (abstract no. 246)Radu C Tincu, Cristian S Cobilinschi, Radu A MacoveiCarol Davila University, Bucharest, Romania

3. Fetal deaths as reported to the US National Poison Data System, 2011-2015 (abstract no. 247)Kristin McCloskey, David Goldberger, David VearrierDrexel University College of Medicine, Philadelphia, US

4. Role of a poison centre in the management of suspected rabies infections (abstract no. 248)Carlotta Giandini, Valeria M Petrolini, Marta Crevani, Eleonora Buscaglia, Giulia Scaravaggi, Mara Garbi, Davide Lonati, Carlo A LocatelliPavia Poison Control Centre - National Toxicology Information Centre - Clinical and Experimental Lab, Toxicology Unit, Maugeri Clinical and Scientific Institutes IRCCS and University of Pavia, Pavia, Italy

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WEDNESDAY 17 MAY 2017

Analytical and forensic toxicology

37(Il-)legal psychoactive ingredients of recreational drugs or dietary supplements: recent findings in a regional toxicology labatoryDieter Müller (1), Hartmud Neurath (1), Annette Groeneveld (1), Adrienne Kilian (1), Gesine Liebetrau (2), Marcel Grapp (1)

(1) University Medical Center, Göttingen, Germany; (2) Helios Klinikum Erfurt, Erfurt, Germany

38Clinical and analytical aspects of quetiapine ingestion: a case report Roberto Zoppellari (1), Ilaria Farinelli (1), Cesare Bertocco (2), Evelina Fortini (1), Giovanna Felisatti (1), Anna L Pinamonti (1), Anna Talarico (2), Rosa M Gaudio (2)

(1) S. Anna University Hospital, Ferrara, Italy; (2) Ferrara University, Ferrara, Italy

39Disintegration and possible bezoar formation of large sized extended release tablets: an in vitro studyAnita Annas (1), Mark Personne (1), Steen H Pedersen (2), Frank Refsgaard (2), Georgios Panagiotidis (3), Shahid Ullah (3), Lotte CG Hoegberg (4)

(1) Swedish Poisons Information Centre, Stockholm, Sweden; (2) Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; (3) Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden; (4) The Danish Poisons Information Centre, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark

40Enzalutamide (Xtandi®) and analytical interference during the determination of digoxinMarion Brunet, Benedicte Lelièvre, Florence Jegou, Chadi Abbara, Alain Turcant, Gaël Le Roux, Marie Bretaudeau DeguigneCHU d’Angers, Angers, France

41Is semi-quantitative toxicological screening in serum using mass spectrometry helpful in triaging intoxicated patients at the Emergency Department? The TOXIC studyPauline M Verputten (1), Saskia J Rietjens (1), Irma S Van Den Hengel-Koot (1), Erik M Van Maarseveen (2), Douwe Dekker (3), Karin AH Kaasjager (3), Irma de Vries (1), Dylan W De Lange (1,4), Laura Hondebrink (1)

(1) Dutch Poisons Information Center, University Medical Center Utrecht (UMCU), Utrecht, The Netherlands; (2) Department of Clinical Pharmacy, UMCU, Utrecht, The Netherlands; (3) Department of Internal Medicine, UMCU, Utrecht, The Netherlands; (4) Department of Intensive Care Medicine, UMCU, Utrecht, The Netherlands

42Onsite oral fluid detection for ketamineDong-Zong Hung (1), Jing-Hua Lin (1), Yu-Chen Lin (2)

(1) China Medical University Hospital, Taichung City, Taiwan; (2) National Chen-Kung University, Tainan City, Taiwan

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Analytical and forensic toxicology (cont)

43Plasma metformin concentration as a diagnostic and prognostic tool for metformin-associated lactic acidosis (MALA)Shasine Veli (1), Lydmila Neykova (1), Silviya Stoykova (2), Boriana Mechkarska (2), Vasil Atanasov (2), Evgenia Stankova (3)

(1) Clinic of Urgent Toxicology, Military Medical Academy, Sofia, Bulgaria; (2) Analytical Toxicology Laboratory, Military Medical Academy, Sofia, Bulgaria; (3) Bulgarian Society of Clinical Toxicology, Sofia, Bulgaria

44Potential pharmacobezoar formation of extended-release tablets and their dissolution: an in vitro study Lotte CG Hoegberg (1), Frank Refsgaard (2), Steen H Pedersen (2), Mark Personne (3), Shahid Ullah (4), Georgios Panagiotidis (4), Anita Annas (3)

(1) Department of Anaesthesiology, The Danish Poisons Information Center, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark; (2) Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; (3) The Swedish Poisons Information Centre, Stockholm, Sweden; (4) Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden

45Red blood cell acetylcholinesterase (RBC-AChE) assay as a first indicative marker in organophosphate poisoningLydmila Neykova (1), Vera Traykova (1), Silviya Stoykova (2), Vasil Atanasov (2), Evgenia Stankova (3)

(1) Clinic of Urgent Toxicology, Military Medical Academy, Sofia, Bulgaria; (2) Analytical Toxicology Laboratory, Military Medical Academy, Sofia, Bulgaria; (3) Bulgarian Society of Clinical Toxicology, Sofia, Bulgaria

Antidotes

46A case report of vasoplegic shock treated with methylene blueTherese Becker, Angela L Chiew, Betty SH ChanPrince of Wales Hospital, Randwick, Australia

47Acute ethylene glycol poisoning and methemoglobinemia after engine coolant ingestion treated with fomepizole and methylene blueMichael Toce (1), Alex Brevil (2), Matthew Griswold (3), Rebecca Bruccoleri (1), Timothy Erickson (2), Michele Burns (1)

(1) Boston Children’s Hospital, Boston, US; (2) Brigham and Women’s Hospital, Boston, US; (3) University of Massachusetts Medical School, Worchester, US

48An academic hospital’s reassuring experience with flumazenilCynthia H Koh, Daniel Lasoff, Bryan Corbett, Cammie Nguyen, Nancy Glober, Allyson KreshakUniversity of California, San Diego, US

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Antidotes (cont)

49Balancing the publication bias: 45 cases of failed lipid rescueSusan C Smolinske (1), Eric Villeneuve (2), Robert S Hoffman (3), Sophie Gosselin (2)

(1) University of New Mexico Poison and Drug Information Center, Albuquerque, US; (2) McGill University Health Centre, Montreal, Canada; (3) New York University School of Medicine, New York, US

50Chemical injury: 4 years’ experience with an advanced approachJozef Verbelen (1), Henk Hoeksema (1), Stan Monstrey (2)

(1) Burn Care Coordinator, Ghent, Belgium; (2) Head of Burn Centre, Ghent, Belgium

51Novel use of sodium thiosulphate: the treatment of calciphylaxisJiri Hlusicka (1), Sergey Zakharov (1), Eva Veisova (1), Martin Ullrych (2), Jaroslav Kubecek (3)

(1) Charles University in Prague, Prague, Czech Republic; (2) Hospital Decin, Decin, Czech Republic; (3) Hospital Nachod, Nachod, Czech Republic

52Characterizing the administration of fomepizole by medical toxicologistsRyan Surmaitis, Kristin McCloskey, David Goldberger, David VearrierDrexel University College of Medicine, Philadelphia, US

Heavy metals poisoning

53Arsenic at breakfast, lunch and dinnerSteven A Seifert, Brandon J Warrick, Susan C SmolinskeUniversity of New Mexico Health Sciences Center, Albuquerque, US

54Attempted suicide with intravenous copper sulphate: a case reportOrnella Spagnolello (1), Ornella Staltari (2), Alessia Garramone (1), Laura Lombardi (3), Davide Lonati (4), Giuliano Bertazzoni (1), Maria Caterina Grassi (2)

(1) Department of Emergency Medicine, Policlinico Umberto I - “Sapienza” University of Rome, Rome, Italy; (2) Emergency Toxicology and Poison Control Centre Unit, Policlinico Umberto I - “Sapienza” University of Rome, Rome, Italy; (3) Department of Immunohematology and Transfusion Medicine, Policlinico Umberto I - “Sapienza” University of Rome, Rome, Italy; (4) Pavia Poison Control Center - National Toxicology Information Centre, Toxicology Unit, Maugeri Clinical and Scientific Institutes IRCCS and University of Pavia, Pavia, Italy

55Lead poisoning screening in children: an example from France, 2002-2013Fanny Pelissier (1), Olivier Guilbert (1), Damien Mouly (2), Camille Lecoffre (2), Nicolas Franchitto (1)

(1) Toulouse-Purpan University Hospital, Toulouse, France; (2) The French Toxicovigilance Network, Toulouse, France

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WEDNESDAY 17 MAY 2017Heavy metals poisoning (cont)

56Lead poisoning in a family due to incense burningYun-Jung Tseng (1), Chun-Hung Chen (2), Dong-Zong Hung (2)

(1) Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan; (2) Division of Toxicology, Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan

57Mercury vapor poisoning associated with home gilding Ming-Ling Wu, Jou-Fang Deng, Chen-Chang YangTaipei Veterans General Hospital, Taipei, Taiwan

58Severe elemental mercury poisoning managed with selenium and N-acetylcysteine supplementationHenry A SpillerCentral Ohio Poison Center, Columbus, US

59Fatal ingestion of copper sulfateAnne Stürzebecher, Dagmar Prasa, Michael Deters, Helmut HentschelPoisons Information Centre Erfurt, Erfurt, Germany

Miscellaneous

60“Hemp oil” ingestion: the dangers of alternative therapiesAngela L Chiew, Steven KeoghThe Children’s Hospital at Westmead, Westmead, Australia

§ 61A delicious meal!Christine Tournoud (1), Laurent Berthelon (1), Agnès Goetzmann (2), Catherine Reitzer (3), Calliope Dirand (1), Eric Bayle (1), Cecile Kermin (2)

(1) Centre anti poison et de toxicovigilance, Strasbourg, France; (2) Direction Departementale de la Protection des Populations, Strasbourg, France; (3) Agence Regionale de Sante Grand Est, Strasbourg, France

62Carbon monoxide: a hidden threat in Shisha barsJutta Trompelt, Oliver Sauer, Andreas StürerMedical University of Mainz, Mainz, Germany

63Cold gel packs: harmless or not?Tina Nyman, Mikko J Parry, Kalle HoppuHUCH Emergency Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland


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Miscellaneous (cont)

§ 64Four fatalities after ingestion of vinegar essence Tara Arif, Kinga Bartecka-Mino, Dieter Genser, Helmut SchielPoisons Information Centre, Vienna, Austria

65Iatrogenic medication errors in residential and care homesMandy Gollmann, Dagmar Prasa, Anne Stürzebecher, Michael DetersPoisons Information Centre Erfurt, Erfurt, Germany

66Intravenous lipid emulsion: interference with laboratory analysesKasper M Petersen, Søren Bøgevig, Tonny S Petersen, Kim P Dalhoff, Mikkel B ChristensenBispebjerg and Frederiksberg University Hospitals, Copenhagen, Denmark

67Nationwide survey to evaluate the differences in resources, implementation and treatment strategies for management of the alcohol withdrawal syndrome (AWS) in England and WalesAjay K Gupta (1), Rachelle Abouchedid (1), Shantelle Quashie (1), Gurbachan Bilku (1), David M Wood (2), Paul I Dargan (2), John RH Archer (2)

(1) Guy’s and St Thomas’ NHS Foundation Trust and King’s Health Partner’s, London, UK; (2) Clinical Toxicology, Guy’s and St Thomas’ NHS Foundation Trust and King’s Health Partner’s and Faculty of Life Sciences and Medicine, King’s College London, London, UK

68Nosocomial transmission of Clostridium butyricum type E responsible for two cases (one outbreak) of infant botulismDavide Lonati (1), Azzurra Schicchi (1), Bruna Auricchio (2), Valeria M Petrolini (1), Fabrizio Anniballi (2), Carlo A Locatelli (1).(1) Pavia Poison Control Centre - National Toxicology Information Centre - Clinical and Experimental Lab, Toxicology Unit, Maugeri Clinical and Scientific Institutes IRCCS and University of Pavia, Pavia, Italy; (2)

National Reference Centre for Botulism (NRCB), Department of Veterinary Public Health and Food Safety, National Institute of Health (ISS), Rome, Italy

69Pre-workout supplements: an analysis of their chemical content and pharmacodynamic interactions with monoamine transporters Anna Rickli, Matthias E LiechtiClinical Pharmacology and Toxicology, Department of Biomedicine, University Hospital Basel, University of Basel, Switzerland


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WEDNESDAY 17 MAY 2017Miscellaneous (cont)

70Wound botulism in Italy (1979-2016)Bruna Auricchio (1), Davide Lonati (2), Marta Crevani (2), Elisa Lainu (2), Francesca Chiara (2), Carlo A Locatelli (2), Fabrizio Anniballi (1)

(1) National Reference Centre for Botulism (NRCB), Department of Veterinary Public Health and Food Safety, National Institute of Health (ISS), Rome, Italy; (2) Pavia Poison Control Centre - National Toxicology Information Centre - Clinical and Experimental Lab, Toxicology Unit, Maugeri Clinical and Scientific Institutes IRCCS and University of Pavia, Pavia, Italy

71Accidental ingestion of nicotine solution for e-cigarettes: a case reportMichele S Milella, Cristiano Ialongo, Susanna M Signoretti, Maria Caterina GrassiEmergency Toxicology and Poison Control Centre Unit, Policlinico Umberto I and “Sapienza” University of Rome, Rome, Italy

Pesticide poisoning

72Clinical and social features in acute organophosphate pesticide poisoning in school children: a 5 year retrospective studyViorela Nitescu (1), Ana Oglinda (2), Nicolae Stanciu (2), Liliana Schirca (2), Victoria Lupu (2), Tatiana Sertinean (2), Cristina Oglinda (3), Casian Mihai (3)

(1) Pediatric Poisoning Center Emergency Clinical Hospital for Children “Grigore Alexandrescu”, Bucharest, Romania; (2) Department of Resuscitation and Toxicology, the Institute of Mother and Child, Chisinau, Republic of Moldova; (3) University of Medicine and Pharmacy “Nicolae Testemitanu”, Chisinau, Republic of Moldova

73Different clinical courses for poisoning with World Health Organization hazard class Ia organophosphatesJeong Mi Moon, Byeong Jo Chun, Young Soo ChoChonnam National University Hospital, Gwagngju, Republic of Korea

74In-hospital outcome and delayed neurologic sequelae of seizures in patients with endosulfan poisoningByeong Jo Chun, Jeong Mi Moon, Young Soo ChoChonnam National University Hospital, Gwagngju, Republic of Korea

75Initial laboratory parameters and correlation to intermediate syndrome in patients with acute organophosphate poisoningByeong Jo Chun, Jeong Mi Moon, Hyunn Ho RyuChonnam National University Hospital, Gwagngju, Republic of Korea § 76An outbreak of bromadiolone poisoning after ingestion of treated riceChun-Hung Chen, Yun-Jung Tseng, Dong-Zong HungChina Medical University Hospital, Taichung, Taiwan


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Poisons centre activities

77The economic efficiency of the Belgian Poison Centre and its impact on national healthcare expensesAnne-Marie K Descamps (1), Dominique M Vandijck (2)

(1) Poison Centre, Brussels, Belgium; (2) Department of Public Health of Ghent University, Ghent, Belgium

78Calls to the Finnish Poison Information Centre concerning poisoning during pregnancy 2001-2015Mervi Saukkonen (1), Liisa Sillanpää (1), Heli Malm (2), Kalle Hoppu (1)

(1) Poison Information Centre, HUCH Emergency Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; (2) Teratology Information Service, HUCH Emergency Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

79Changes in smoking habits and the sales of nicotine replacement therapy seem to explain the variation in the number of calls to FPIC concerning nicotine exposure Pirjo Tynjälä (1), Katja Valkeapää (2), Mikko J Parry (1), Markku Pasanen (2), Kalle Hoppu (1)

(1) Poison Information Centre, Helsinki, Finland; (2) University of Eastern Finland, School of Pharmacy, Kuopio, Finland

80Exposure to fabric protector sprays: analysis of trends and clinical features reported to the UK National Poisons Information Service, 2008-2014Michael I Crockett (1), John P Thompson (1), Sally M Bradberry (2), Euan A Sandilands (3), Simon HL Thomas (4), James M Coulson (1)

(1) National Poisons Information Service, Cardiff, UK; (2) National Poisons Information Service, Birmingham, UK; (3) National Poisons Information Service, Edinburgh, UK; (4) National Poisons Information Service, Newcastle, UK

81How tackling an increase in call volume resulted in a drop of complaints at a Poisons Information Center (PIC)Iris Venster, Claudine C Hunault, Anja P Wijnands-Kleukers, Tessa E Van Riemsdijk, Irma de VriesUniversity Medical Center Utrecht (UMCU), Utrecht, The Netherlands

82Human tilmicosin exposures, clinical features and outcome: a review of enquiries received by the UK NPIS, 2008-2016Eleri Thomas (1), Sally M Bradberry (2), Euan A Sandilands (3), Simon HL Thomas (4), John P Thompson (1)


83Impact of Zika virus spread on a Florida Poison Information CenterTamas R Peredy (1), Alfred Aleguas (2)

(1) University of South Florida, Tampa, US; (2) Tampa General Hospital, Tampa, US

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Poisons centre activities (cont)

84Primary poisoning prevention and awareness: the Estonian experienceRuth Kastanje (1), Mare Oder (2)

(1) Estonian Poison Information Centre, Tallinn, Estonia; (2) Estonian Health Insurance Fund, Tallinn, Estonia

85Publicity as a public relation strategy in poisons information centre survival Michaela Strautins, Lotte CG HoegbergDepartment of Anaesthesiology, The Danish Poisons Information Centre, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark 86Risks from and concerns about methamphetamine exposures: a review of enquiries to the New Zealand Poisons CentreMichael G Beasley, Lucy M ShieffelbienUniversity of Otago, Dunedin, New Zealand

87The CLP Unique Formula Identifier (UFI) for hazardous mixtures will help poisons centres (PC) give the best advice and will increase the value of PC case records for regulatory risk assessment under REACHHerbert DeselFederal Institute for Risk Assessment (BfR), Berlin, Germany

88The role of the Serbian National Poison Control Center in the management of poisoning in childrenJasmina Jović-Stošič, Slavica Vucinic, Tomislav Rezic, Jasmina Pavlovic Baaklini, Gordana Vuković-ErcegovićNational Poison Control Centre, Military Medical Academy, Belgrade, Serbia

89Therapeutic errors: the experience of the Florence Poison Center Arianna Dilaghi (1), Marco Cirronis (1), Francesco Gambassi (2), Brunella Occupati (2), Alessandra Ieri (2), Guido Mannaioni (1), Andrea Missanelli (2), Emanuela Masini (1), Alessandra Pistelli (2)

(1) Department of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Firenze, Italy; (2) Clinical Toxicology Unit, Azienda Ospedaliero Universitaria Careggi, Firenze, Italy

90Trends in enquires to the UK National Poisons Information Service (NPIS) involving “preschool” (0-4 years) children in 2015. Might knowledge of circumstances help plan prevention strategies?Nicola Wheatley (1), Gillian A Cooper (1), John P Thompson (1), Sally M Bradberry (2), Euan A Sandilands (3), Simon HL Thomas (4)


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Poisons centre activities (cont)

91Venlafaxine overdoses reported to the UK National Poisons Information Service over a 5 year periodMichael I Crockett (1), John P Thompson (1), Sally M Bradberry (2), Euan A Sandilands (3), Simon HL Thomas (4), James M Coulson (1)


92Vietnamese centipede: a new trend in dangerous pets?Rachel Vickery (1), Sally M Bradberry (2), Euan A Sandilands (3), Simon HL Thomas (4), John P Thompson (1)


Toxicosurveillance

93The impact of repackaging from bottle to blister on paediatric intoxications with the levothyroxine brand Thyrax®Antoinette JHP van Riel, Tessa E van Riemsdijk, Claudine C Hunault, Irma de VriesUniversity Medical Center Utrecht (UMCU), Utrecht, The Netherlands

Veterinary toxicology

94Alphachloralose poisoning in dogs: a case seriesAnita Annas (1), Frida Norrvik (2), Lis-Marie Johansson (2)

(1) Swedish Poisons Information Centre, Stockholm, Sweden; (2) AniCura Animal Hospital, Falun, Sweden

95Fatal mushroom poisoning in a dogAndrea Gleed (1), Michael Jordan (2), Nicola Bates (3), Azar Alexander-Sefre (3), Nick Edwards (3)

(1) Vets4Pets, Hull, UK; (2) Fungus Conservation Trust, Axminster, UK; (3) Veterinary Poisons Information Service (VPIS), London, UK

96Gabapentin ingestion in dogs and cats Lilia Kazemi-Egbunike, Nicola BatesVeterinary Poisons Information Service (VPIS), London, UK

POSTERS

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Veterinary toxicology (cont)

97Lamotrigine is cardiotoxic to dogsNicola Bates, Nick Edwards, Zoe TizzardVeterinary Poisons Information Service (VPIS), London, UK

98Metaldehyde ingestion in 18 domestic equinesTiffany Blackett, Nicola BatesVeterinary Poisons Information Service (VPIS), London, UK

99Neonicotinoid insecticide exposure in cats and dogsStella Matumo, Nicola BatesVeterinary Poisons Information Service (VPIS), London, UK

100Phenoxyacetic acid derivative herbicide exposure in 101 dogsNiamh Allen, Nicola BatesVeterinary Poisons Information Service (VPIS), London, UK

101Pregabalin ingestion in dogs and catsNicola Robinson, Nicola BatesVeterinary Poisons Information Service (VPIS), London, UK

102Suspected synthetic cannabinoid ingestion in dogs: a case seriesMark Van-de-Velde, Nicola Bates, Nick EdwardsVeterinary Poisons Information Service (VPIS), London, UK

103Accidental poisoning in dogs from intraruminal monensin devices expelled by cowsJonas Van Baelen, Geert Verstegen, Martine MostinBelgian Poison Centre, Brussels, Belgium

104Comparison of the Poisoning Severity Score and National Poison Data System schemes for severity assessment of dog poisoningsSarah McFarland (1), Alvin Bronstein (2), Shireen Banerji (3), Jane Leblond (4), Kathrin Begemann (1), Matthias Greiner (1)

(1) Federal Institute of Risk Assessment, Berlin, Germany; (2) Hawaii State Department of Health, Honolulu, US; (3)

Rocky Mountain Poison and Drug Centre, Denver, US; (4) Creighton University School of Pharmacy, Omaha, US

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THURSDAY 18 MAY 2017

Adverse effects

139A hard drug error: naloxogel-induced opioid withdrawalMorgan AA Riggan (1), Donald B Robinson (2), Robert S Hoffman (1), Patricia Phan (3), Silas W Smith (1), Rana Biary (1)

(1) NYU School of Medicine, New York, US; (2) New York City Control Center, New York, US; (3) St. Francis Hospital, Roslyn, US

140Antiepileptic drug-induced hypocalcemia as the main cause of uncontrolled seizures in long-term treatment of epilepsy Gabija Mikuleviciene, Robertas BadarasRepublican Vilnius University Hospital, Vilnius, Lithuania

§ 141Fatal outcome after ingestion of dimethyl sulfoxide as a miracle cureNina Glaser (1), Johannes Manhart (2), Maren Oldörp (3), Miriam Friedemann (1), Herbert Desel (1)

(1) Federal Institute for Risk Assessment, Berlin, Germany; (2) Rostock University Medical Center, Rostock, Germany; (3) Municipal Hospital Südstadt Rostock, Rostock, Germany

142Fatalities in low-weight children related to supratherapeutic doses of paracetamol in countries with unrestricted access to medicationMohamad Haidar (1), Kensute Tkahashi (1), Nicoletta Belio (2), Jean-Claude Alvarez (3), Robin E Ferner (4), Luke Bawo (5), Klaudia Porten (1), Frederic J Baud (2)

(1) Epicentre, Paris, France; (2) Medecins Sans Frontières, Paris, France; (3) AP-HP; University VSQ, Paris, France; (4) City Hospital, Birmingham, UK; (5) Ministry of Health and Social Welfare, Monrovia, Liberia

143Generalised tonic-clonic seizures provoked after short term over-the-counter treatment with a combination of pseudoephedrine hydrochloride, paracetamol and dextromethorphan hydrobromideMojca Dobaja, Damjan Grenc, Miran BrvarUniversity Medical Centre Ljubljana, Ljubljana, Slovenia

144Hepatotoxicity of tyrosine kinase inhibitorsFranziska Paech, Jamal Bouitbir, Stephan Krähenbühl

University of Basel, Basel, Switzerland

145Hypersensitivity secondary to naltrexone depot injectionDavid Goldberger (1), Suraj Rajasimhan (2), Alin Gragossian (1), Rita McKeever (1), David Vearrier (1), Michael I Greenberg (1)

(1) Drexel University College of Medicine, Philadelphia, US; (2) Hahnemann University Hospital, Philadelphia, US


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POSTERS


Adverse effects (cont)

146Monoclonal antibodies and other immunomodulating drugs: enquiries to a poisons information serviceAlison M Good (1), Gillian Jackson (1), Caroline McGrory (1), Simon HL Thomas (2), John P Thompson (3), Sally M Bradberry (4), Euan A Sandilands (1)

(1) NPIS Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK; (2) NPIS Newcastle, Regional Drug and Therapeutics Centre, Newcastle upon Tyne, UK; (3) NPIS Cardiff, University Hospital Llandough, Cardiff, UK; (4)

NPIS Birmingham, City Hospital, Birmingham, UK

147Pediatric cardiac arrest after Cyclomydril(R) eye dropsEike Blohm, Jeffrey T LaiUniversity of Massachusetts, Worcester, US

§ 148Perampanel overdose causing a prolonged dissociated state Kai Li, Daniel Lasoff, Craig Smollin, Binh LyCalifornia Poison Control Center, San Francisco, US

149Predicting clinically relevant drug induced liver injuryFelix Hammann, Jürgen DreweUniversity and University Hospital Basel, Basel, Switzerland

150Take a big GuLP: recurrent hypoglycemia from liraglutide responds to octreotideRana Biary, Lindsay M Fox, Robert S HoffmanNYU School of Medicine, New York, US

151The catechol-O-methyltransferase inhibitors tolcapone and entacapone uncouple and inhibit the mitochondrial respiratory chain in HepaRG cellsDavid Grünig, Andrea Felser, Jamal Bouitbir, Stephan KrähenbühlUniversity Hospital, Basel, Switzerland

152The impact of polypharmacy and drug interactions on the onset of adverse drug reactions Marco Morina, Pierpaolo Cascino, Giscardo F Panzavolta, Andrea F Stella, Adriana M Tomoiaga, Franca DavanzoMilan Poison Control Center, Milan, Italy


44

POSTERS


Drug abuse poisoning

153Acute “bath salts” intoxications: analytical findings and clinical featuresTobias Zellner (1), Marco Diestelmann (2), Liane D Paul (2), Rudolf Pfab (1), Florian Eyer (1)

(1) Klinikum rechts der Isar – School of Medicine, Technical University of Munich, Munich, Germany; (2)

Institute of Forensic Medicine, Ludwig-Maximilian-University, Munich, Germany

154Acute effects after consumption of the novel synthetic cannabinoids 5F-ADB Bernardino Barceló (1), Isabel Gomila (1), Manuela Pellegrini (2), Verena Angerer (3), Simona Pichini (2), Christopher Yates (1), Victoria L Corominas (1), Jordi Puiguriguer (1), Volker Auwärter (3)

(1) Hospital Universitari Son Espases, Research Institute of Health Sciences (IdISPa), Palma de Mallorca, Spain; (2) Istituto Superiore di Sanità, Rome, Italy; (3) Institute of Forensic Medicine, University of Freiburg Medical Center, Freiburg, Germany

155Acute health problems due to recreational drug use in patients presenting to an urban emergency department in SwitzerlandEvangelia Liakoni (1), Sabine Müller (1), Adrian Stoller (1), Matthias E Liechti (2), Meret Ricklin (1), Aristomenis K Exadaktylos (1)

(1) Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; (2) University Hospital Basel and University of Basel, Basel, Switzerland

156Acute intoxication involving the new psychoactive substance alpha-pyrrolidinobutiophenone (α-PBP): results from the Swedish STRIDA projectLisa Franzen (1), Olof Beck (2), Anders Helander (2), Matilda Bäckberg (1)

(1) Swedish Poisons Information Centre, Stockholm, Sweden; (2) Karolinska Institutet and Karolinska University Laboratory, Stockholm, Sweden

157Addressing the public health impact of new psychoactive substances: early analysis of the effects of the UK’s Psychoactive Substances Act on poisons centre enquiries related to drugs of misuseIsraa Al Banaa (1), Leonard C Hawkins (2), David J Lupton (3), Gillian Jackson (3), Euan A Sandilands (3), John P Thompson (4), Sally M Bradberry (5), Simon L Hill (1), Simon HL Thomas (1)

(1) Newcastle University, Newcastle, UK; (2) Newcastle Hospitals NHS Foundation Trust, Newcastle, UK; (3) Royal Infirmary of Edinburgh, Edinburgh, UK; (4) Cardiff University Hospital Llandough, Cardiff, UK; (5) Sandwell and West Birmingham NHS Trust, Birmingham, UK

158An example of a new toxicological disease and a new social problem related to the abuse of and addiction to new psychoactive substancesEleonora Buscaglia (1), Azzurra Schicchi (1), Davide Lonati (1), Giuseppa Calabrò (2), Pietro Papa (3), Antonella Valli

(3), Marcello Di Tuccio (3), Carlo A Locatelli (1)


NESMOS (Neuroscience, Mental Health, and Sensory Organs) Department, Sapienza University, School of Medicine and Psychology, Sant’Andrea Hospital, Rome, Italy; (3) Laboratory of Analytical Toxicology, Clinical Chemistry Service, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy

45

POSTERS


Drug abuse poisoning (cont)

159An online survey on misuse of benzodiazepines and “Z drugs” in SingaporeWui Ling Chan (1), David M Wood (2), Colleen M Haynes (3), Karilynn M Rockhill (3), Jody L Green (3), Paul I Dargan (2)

(1) Tan Tock Seng Hospital, Singapore; (2) Clinical Toxicology, Guy’s and St Thomas’ NHS Foundation Trust and King’s Health Partners and Faculty of Life Sciences and Medicine, King’s College London, UK; (3) Rocky Mountain Poison & Drug Center, Denver, US

160Ayahuasca intoxication: two case reportsAnna Celentano, Marco Morina, Rossana Borghini, Angelo Travaglia, Franca DavanzoMilan Poison Control Center, Milan, Italy

161Baclofen poisoning in France reported to French Poison Centers: a five-year retrospective studyFanny Pelissier (1), Luc De Haro (2), Florence Cardona (3), Cyndie Picot (3), Emmanuel Puskarczyk (4), Jean-Marc Sapori (5), Christine Tournoud (6), Nicolas Franchitto (1)

(1) Toulouse-Purpan University Hospital, Toulouse, France; (2) Sainte Marguerite Hospital, Marseille, France; (3)

French National Agency for Medicines and Health Products Safety, Saint Denis, France; (4) Nancy University Medical Center, Nancy, France; (5) Hospices Civils de Lyon, Lyon, France; (6) Hôpital Civil, Strasbourg, France 162Capsaicin cream in the treatment of cannabinoid hyperemesis syndrome: relief from the “joint” painZachary T Hafez, David B Liss, Evan S Schwarz, Michael E MullinsWashington University School of Medicine, Saint Louis, US

163Clinical features following analytically confirmed use of 5F-ADB, a synthetic cannabinoid receptor agonist. A report from the UK IONA study Muhammad EMO Elamin (1), Michael Dunn (2), Paul I Dargan (3), David M Wood (3), Simon Tucker (4), Simon L Hill

(2), Simon HL Thomas (2)

(1) Newcastle Hospitals NHS Foundation Trust, Newcastle, UK; (2) Newcastle University, Newcastle, UK; (3) King’s College London, London, UK; (4) Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool, UK

164Clinical features in emergency department patients with analytically confirmed intake of ADB-CHMINACA: a case series from the prospective study SPICE II plusMaren Hermanns-Clausen (1), Josephine Kithinji (1), Verena Angerer (2), Florian Franz (2), Florian Eyer (3), Volker Auwärter (2)

(1) Center for Pediatrics, University of Freiburg Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany; (2) University of Freiburg Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany; (3) Internal Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

46

POSTERS



165Clinical features of severe intoxications associated with analytically confirmed use of NBOMeCarlo A Locatelli (1), Eleonora Buscaglia (1), Antonella Valli (2), Loretta Rocchi (2), Laura Rolandi (2), Marcello Di Tuccio (2), Giulia Scaravaggi (1), Marta Crevani (1), Pietro Papa (2)

(1) Pavia Poison Control Centre - National Toxicology Information Centre - Clinical and Experimental Lab, Toxicology Unit, Maugeri Clinical and Scientific Institutes IRCCS and University of Pavia, Pavia, Italy and Clinical-Toxicology Coordinating Centre of the National Early Warning System, Presidency of the Council of Ministers, Rome, Italy; (2) Laboratory of Analytical Toxicology, Clinical Chemistry Service, IRCCS Policlinico San Matteo Foundation, Pavia, Italy

166Cocaethylene formation following ethanol and cocaine use: a case reportBrunella Occupati (1), Angelo Rotulo (1), Filippo Gori (1), Francesco Gambassi (1), Elisabetta Bertol (2), Emanuela Masini (3)

(1) Toxicology Unit and Poison Control Center, AOU Careggi, Florence, Italy; (2) Department of Health Science, Section of Forensic Medicine, Florence, Italy; (3) Toxicology Unit and Poison Control Center, AOU Careggi; Department of NEUROFARBA, University of Florence, Florence, Italy

167Comparison of prevalence of illicit recreational drug use in the annual Crime Survey England and Wales and the UK Survey of Non-Medical Use of Prescription Drugs Programme between 2014 and 2016David M Wood (1), Jody L Green (2), Colleen M Haynes (2), Karilynn M Rockhill (2), Paul I Dargan (1)

(1) Guy’s and St Thomas’ NHS Foundation Trust and King’s Health Partners; Faculty of Life Sciences and Medicine, King’s College London, London, UK; (2) Rocky Mountain Poison & Drug Center, Denver Health, Denver, US

168Confirmed intoxication by 2-methoxphenidine and flubromazepam mimicking ischemic cerebral diseaseAntonella Valli (1), Marcello Di Tuccio (1), Davide Lonati (2), Mara Garbi (2), Eleonora Buscaglia (2), Pietro Papa (1), Carlo A Locatelli (2)

(1) Laboratory of Analytical Toxicology, Clinical Chemistry Service, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; (2) Pavia Poison Control Centre - National Toxicology Information Centre-Clinical and Experimental Lab, Toxicology Unit, Maugeri Clinical and Scientific Institutes IRCCS and University of Pavia, Pavia, Italy

169Does one affect the other? A 5-year characterization of US Poison Center data comparing human marijuana and synthetic cannabinoid exposuresShireen Banerji (1), Christopher Hoyte (1,2)

(1) Rocky Mountain Poison Center, Denver, US; (2) University of Colorado School of Medicine, Aurora, US

170Drowning in bath salts: MDPV in northern GermanyMartin Ebbecke, Andreas Schaper, Elke Färber, Annette Groeneveld, Adrienne Kilian, Marcel GrappUniversity Medical Center, Göttingen, Germany

47

POSTERS



171Gamma-hydroxybutyrate intoxication in Italy related to a pharmaceutical preparationValeria M Petrolini (1), Valentina Costa (2), Marta Crevani (1), Giulia Scaravaggi (1), Giorgio Ricci (2), Carlo A Locatelli (1)


Emergency Department, Universitary Hospital of Verona (AOUI), Verona, Italy

172Increase in Emergency Department presentations in Europe related to the use of synthetic cannabinoid receptor agonistsDavid M Wood (1), Alison M Dines (1), Knut Erik Hovda (2), Fridtjof Heyerdahl (2), Christopher Yates (3), Isabelle Giraudon (4), Paul I Dargan (1), Euro-DEN Plus Research Group (5)

(1) Guy’s and St Thomas’ NHS Foundation Trust and Faculty of Life Sciences and Medicine, King’s College London, London, UK; (2) Oslo University Hospital, Oslo, Norway; (3) Hospital Universitari Son Espases, Mallorca, Spain; (4) European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Lisbon, Portugal; (5) Guy’s and St Thomas’ NHS Foundation Trust, London, UK

173Moderate and severe carbon monoxide intoxication related to waterpipe useValeria M Petrolini, Federico Vigorita, Mara Garbi, Marta Crevani, Francesca Chiara, Carlo A LocatelliPavia Poison Control Centre - National Toxicology Information Centre - Clinical and Experimental Lab, Toxicology Unit, Maugeri Clinical and Scientific Institutes IRCCS and University of Pavia, Pavia, Italy

174Necessity of vigilant supervision of body stuffers: a case report Marius Perminas, Egle Zelbiene, Jonas Surkus, Ruta Leksiene, Nedas JasinskasLithuanian University of Health Sciences, Kaunas, Lithuania

175Non-medical use of loperamide in the UKPaul I Dargan (1), Colleen M Haynes (2), Patrick May (2), Karilynn M Rockhill (2), David M Wood (1), Jody L Green (2)

(1) Guy’s and St Thomas’ NHS Foundation Trust, London, UK; (2) Rocky Mountain Poison and Drug Center, Denver, US

176Novios muertos: two confirmed fatalities from U-47700Stephen A Harding (1), Rana Biary (1), Robert S Hoffman (1), Mark K Su (2), Gail A Cooper (3), Silas W Smith (1)

(1) Ronald O. Perelman Department of Emergency Medicine, NYU School of Medicine, New York, US; (2) Ronald O. Perelman Department of Emergency Medicine, NYU School of Medicine and New York City Poison Control Center, New York, US; (3)

Office of the Chief Medical Examiner and Department of Forensic Medicine, NYU School of Medicine, New York, US

177Patients self-discharging during treatment for acute poisoning by substances of abuseOdd Martin Vallersnes (1), Dag Jacobsen (2), Øivind Ekeberg (1), Mette Brekke (1)

(1) University of Oslo, Oslo, Norway; (2) Oslo University Hospital, Oslo, Norway

48

POSTERS



178Patterns of use of licensed medicines in Emergency Department acute recreational drug toxicity presentations reported to the European Drug Emergencies Network Plus (Euro-DEN Plus)Alison M Dines (1), Paul I Dargan (1), John RH Archer (1), Knut Erik Hovda (2), Fridtjof Heyerdahl (2), Christopher Yates (3), Isabelle Giraudon (4), David M Wood (1), Euro-DEN Plus Research Group (1)

(1) Guy’s and St Thomas’ NHS Foundation Trust and King’s Health Partners, London, UK; (2) Oslo University Hospital, Oslo, Norway; (3) Hospital Universitari Son Espases, Mallorca, Spain; (4) European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Lisbon, Portugal

179Pregabalin misuse and abuse reported to US Poison CentersChristopher Hoyte (1,2), Shireen Banerji (2), Alvin Bronstein (3)

(1) University of Colorado School of Medicine, Aurora, US; (2) Rocky Mountain Poison and Drug Center, Denver, US; (3) Emergency Medical Services Injury Prevention System Branch, Honolulu, US

§ 180Recreational carfentanil: the devil in disguiseSabine Müller (1), Susanne Nussbaumer (2), Gabriel Plitzko (1), Roger Ludwig (1), Wolfgang Weinmann (2), Evangelia Liakoni (1)

(1) Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; (2) Institute of Forensic Medicine, University of Bern, Bern, Switzerland

181Synthetic cannabinoid receptor agonist (SCRA) detection from pooled urine samples in central LondonJohn RH Archer (1), Simon Hudson (2), Rachelle Abouchedid (3), James Ho (3), David M Wood (1), Paul I Dargan (1)

(1) Guy’s and St Thomas’ NHS Foundation Trust and King’s Health Partner’s and Faculty of Life Sciences and Medicine, King’s College London, London, UK; (2) LGC Health Sciences, Fordham, UK; (3) Clinical Toxicology, Guy’s and St Thomas’ NHS Foundation Trust and King’s Health Partners, London, UK

182Synthetic cannabinoid receptor agonists identified in patients with severe clinical toxicity in England: a report from the Identification Of Novel psychoActive substances (IONA) studySimon L Hill (1), Michael Dunn (2), Paul I Dargan (3), David M Wood (3), Simon Tucker (4), Johann Grundlingh (5), Ashraf Kamour (6), Paul Acheampong (7), Simon HL Thomas (2)

(1) Newcastle Hospitals NHS Foundation Trust, Newcastle, UK; (2) Newcastle University, Newcastle, UK; (3) King’s College London, London, UK; (4) Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool, UK; (5) Royal London Hospital, London, UK; (6) North Manchester General Hospital, Manchester, UK; (7) Royal Liverpool University Hospital, Liverpool, UK


49

POSTERS



183The migration of drugs of abuse from Europe to Denmark: analysis of pooled anonymous urine from urinals at Roskilde Festival 2016Lotte CG Hoegberg (1), Cecilie Christiansen (2), Jesper Soe (3), Rasmus Telving (4), Mette F Andreasen (4), Dan Staerk (2), Lona L Christrup (2), Kenneth T Kongstad (2)

(1) Department of Anaesthesiology, The Danish Poisons Information Center, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark; (2) Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; (3) Department of Anaesthesiology, Copenhagen University Hospital Hvidovre, Denmark and Roskilde Festival, Roskilde, Denmark; (4) Department of Forensic Medicine, Aarhus University, Aarhus, Denmark

§184The syndrome of inappropriate antidiuretic hormone secretion due to the 3-methyl-N-methylcathinone (3-MMC) intoxicationVid Leban (1), Andrej Fister (2), Miran Brvar (1)

(1) University Medical Centre Ljubljana, Ljubljana, Slovenia; (2) University of Ljubljana, Ljubljana, Slovenia

185Use of technology to study bystander naloxone distributionJeffrey T Lai (1), Peter R Chai (1), Katherine L Boyle (2), Edward W Boyer (1)

(1) University of Massachusetts Medical School, Worcester, US; (2) Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, US

186Peyote use in the US, 2002-2013Kristin McCloskey, David Vearrier, Rita McKeever, David GoldbergerDrexel University College of Medicine, Philadelphia, US

187Cannabis smoke inhalation: an insidious cause of spontaneous pneumothorax in teenagers Valentina A Ferro, Mara Pisani, Valerio Pardi, Marco Marano, Maria Barbieri, Anna Maria Musolino, Umberto Raucci, Antonino RealeBambino Gesù Children’s Hospital, IRCCS, Rome, Italy


50

POSTERS


Medication poisoning (including paracetamol and anti-convulsive drugs)

188Poisoning severity in intentional self-harm as a function of class of medication ingestedKenneth R Conner, Timothy J Wiegand, Rachel Gorodetsky, Rachel Schult, Kimberly KaukeinenUniversity of Rochester Medical Center, Rochester, US

189A characterization of gabapentin abuse and misuse reported to US Poison CentersChristopher Hoyte (1,2), Shireen Banerji (2)


190A complicating factor: hidden salicylate poisoning in a septic patientTalan A Parnell, John P ThompsonUK National Poisons Information Service, Cardiff, UK

191A rare but severe case of minoxidil poisoning in a childGaël Le Roux, Jeremy Lecot, Marion Brunet, Florence Jegou, David BoelsCHU d’Angers, Angers, France

192Moved to Friday 19 May

193Acute valacyclovir overdose causing renal failure and neurotoxicityKarin Rafstedt (1), Jonas Höjer (1), Eva K Olsson (1), Jonas Feldthusen (2)

(1) Swedish Poisons Information Centre, Stockholm, Sweden; (2) Norra Älvsborg Hospital, Trollhättan, Sweden

194Baclofen self-poisoning: is extrarenal epuration efficient in normorenal patients?Marion Brunet (1), Gaël Le Roux (1), Maxime Leger (1), Pierre-Andre Billat (2), Nicolas Lerolle (1), David Boels (1)

(1) CHU d’Angers, Angers, France; (3) Universite d’Angers, Angers, France

195Cardiovascular findings in acute poisoning with anticonvulsant drugs in childrenIolanda C Vivisenco, Coriolan E UlmeanuEmergency Hospital for Children “Grigore Alexandrescu”, Bucharest, Romania

196Clonidine exposures in children under 6 years: cases reported to Australia’s largest poisons information centreRose Cairns (1,2), Jared A Brown (2), Nicholas A Buckley (1)

(1) New South Wales Poisons Information Centre, The Children’s Hospital at Westmead, Sydney, Australia; (2)

Sydney Medical School, University of Sydney, Sydney, Australia

51

POSTERS


Medication poisoning (including paracetamol and anti-convulsive drugs) (cont)

197Delayed Ogilvie Syndrome induced by acute clozapine overdoseVesna Mijatović (1), Jasmina Jović-Stošič (2), Nataša Perković-Vukčević (2), Gordana Vuković-Ercegović (2), Olivera Potrebić (2), Snežana Đorđević (2), Zoran Šegrt (3)

(1) Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia; (2) National Poison Control Center, Military Medical Academy, Belgrade, Serbia; (3)

Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia

198Dihydropyridine calcium channel blocker toxicity and the renin angiotensin axisBetty SH Chan (1), Angela L Chiew (1), Colin B Page (2), Geoffrey K Isbister (3), Buckley A Nicholas (4)

(1) Prince of Wales Hospital, Sydney, Australia; (2) Princess Alexandra Hospital, Sydney, Australia; (3) Calvary Mater Hospital, Newcastle, Australia; (4) University of Sydney, Sydney, Australia

199Does serum procalcitonin predict the onset of toxic acute hepatitis in acetaminophen poisoning?Shireen Salem (1), Antoine Goury (1), Isabelle Malissin (1), Pierre Garçon (1), Lamia Kerdjana (1), Sebastian Voicu (1), Nicolas Deye (1), Herve Gourlain (2), Eric Vicaut (3), Bruno Megarbane (1)

(1) Department of Medical and Toxicological Critical Care, Lariboisière Hospital, Paris, France; (2) Laboratory of Toxicology, Lariboisière Hospital, Paris, France; (3) Biostatistics, Lariboisière Hospital, Paris, France

200Extended-release (XR) quetiapine overdose is associated with delayed development of peak toxicity and prolonged recovery when compared to immediate-release (IR) quetiapine overdose: a retrospective cohort studyLucy M Taylor (1), Andis Graudins (2)

(1) Monash University, Clayton, Australia; (2) Monash Health and Monash University, Dandenong, Australia

201Favorable acute toxicity profile of morclofone in childrenKatharina E Hofer, Hugo Kupferschmidt, Christine Rauber-LüthyNational Poisons Centre, Tox Info Suisse, Associated Institute of the University of Zurich, Zurich, Switzerland

§ 202Fomepizole, dialysis and an increased dose of N-acetylcysteine in a case of massive paracetamol ingestionÅsa Appelqvist (1), Erik Lindeman (2)

(1) Skaraborg Hospital, Skövde, Sweden; (2) Swedish Poisons Information Centre, Stockholm, Sweden

203High in-hospital death rate from calcium channel blocker and beta-blocker poisoningsMarkus Tellerup, Johanna Nordmark-Grass, Erik LindemanSwedish Poisons Information Centre, Stockholm, Sweden


52

POSTERS


Medication poisoning (including paracetamol and anti-convulsive drugs) (cont)204Methotrexate therapeutic errors in non-oncology settingsAzzurra Schicchi, Valeria M Petrolini, Serena Marra, Maria Mascolo, Francesca Chiara, Giulia Scaravaggi, Sarah Vecchio, Carlo A LocatelliPavia Poison Control Centre - National Toxicology Information Centre - Clinical and Experimental Lab, Toxicology Unit, Maugeri Clinical and Scientific Institutes IRCCS and University of Pavia, Pavia, Italy

205Nearly all cases of clioquinol intoxication result from medication errorsAgnes G van Velzen, Irma de VriesUniversity Medical Center Utrecht (UMCU), Utrecht, The Netherlands

206Nicotinic acid overdose mimicking sepsisMichael Hodgman, Christine StorkUpstate Medical University, Syracuse, US

207Parenteral iron overdose: the experience of the UK National Poisons Information ServiceLeonard C Hawkins (1), John P Thompson (2), Euan A Sandilands (3), Sally M Bradberry (4), Simon HL Thomas (1)

(1) Regional Drug and Therapeutics Centre, Newcastle upon Tyne, UK; (2) University Hospital Llandough, Cardiff, UK; (3) Scottish Poisons Information Bureau, Edinburgh, UK; (4) City Hospital, Birmingham, UK

208Poisonings with modified or prolonged release paracetamol tablets in DenmarkAnders Schultz, Tonny S Petersen, Kim P DalhoffBispebjerg and Frederiksberg University Hospital, Copenhagen, Denmark

209Pregabalin abuse in Munich: an increasing problemNicolas Zellner, Florian Eyer, Tobias ZellnerKlinikum rechts der Isar – School of Medicine, Technical University of Munich, Munich, Germany

210Prolonged toxicity from amphetamine and quetiapine following overdose in a patient also taking cobicistatDarren M Roberts, Jad Othman, Andrew H DawsonRoyal Prince Alfred Hospital, Sydney, Australia

211Recurrent seizures following a paroxetine overdose in an infantMarco Conte (1), Emanuela Masini (1), Francesco Gambassi (2), Alessandra Pistelli (2), Federico Melani (3), Elena Cravedi (3)

(1) Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy; (2) Medical Toxicology Unit and Regional Reference Center for Perinatal Toxicology, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; (3) Pediatric Neurology Unit, A. Meyer Children’s Hospital – University of Florence, Florence, Italy

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POSTERS


Medication poisoning (including paracetamol and anti-convulsive drugs) (cont)

212Severe and prolonged symptoms after intrathecal administration of gadobutrol (Gadovist®)Anne Stürzebecher, Dagmar Prasa, Michael Deters, Helmut HentschelPoisons Information Centre Erfurt, Erfurt, Germany

213Third degree heart block with accelerated junctional rhythm in verapamil overdose: a case seriesMaxwell A Thompson (1), Nathan P Charlton (2), William F Rushton (1)

(1) University of Alabama at Birmingham, Birmingham, US; (2) University of Virginia, Charlottesville, US

214Thyrotoxicosis and anorectic pills: a case reportMichele S Milella (1), Susanna M Signoretti (1), Orietta Staltari (1), Davide Lonati (2), Maria Caterina Grassi (1)

(1) Emergency Toxicology and Poison Control Centre Unit, Policlinico Umberto I and “Sapienza” University of Rome, Rome, Italy; (2) Pavia Poison Control Centre and National Toxicology Information Centre, Toxicology Unit, IRCCS Maugeri Foundation, Pavia, Italy

215Unintentional ingestion of apixaban in a toddlerGal Neuman (1), Alfred Cahana (1), Smadar Shilo (1), Yedidia Bentur (2)

(1) Rambam Health Care Campus, Haifa, Israel; (2) Rambam Health Care Campus; The Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

216Validation analysis of poisoning severity scores in intentional self-poisoning casesTimothy J Wiegand, Kenneth R Conner, Rachel Schult, Rachel Gorodetsky, Kimberly KaukeinenUniversity of Rochester Medical Center, Rochester, US

217Zopiclone poisoning and methemoglobinemia: French poison control centers data, 1999 to 2016Lise Capaldo (1), Ingrid Blanc (2), Jacques Manel (2), Patricia Bernadet (2), Magali Labadie (2)

(1) Poison Control Center, Bordeaux, France; (2) Poison Control Center, Paris, France

§ 218Symptomatic elevation of anti-epileptic drug concentrations after addition of hemp oil extract to a therapeutic regimenMuhammad M Khalid (1), Elizabeth D Waring (2), David Vearrier (1), Rita McKeever (1), Michael I Greenberg (1)

(1) Drexel University College of Medicine, Philadelphia, US; (2) Tulane University School of Medicine, Philadelphia, US

219Paracetamol-induced renal failure: an underestimated consequence of delayed managed overdosesBastien Domange, Corinne Schmitt, Romain Torrents, Audrey Boulamery, Nicolas Simon, Luc De HaroMarseille Poison Centre, Marseille, France


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Animal poisoning

255A case of voluntary exposure to the venom of the giant leaf frog (Phyllomedusa bicolor)Lieven De Smedt (1), Martine Mostin (2), Peter De Paepe (1), Petra Van de Sijpe (2)

(1) University Hospital Ghent, Ghent, Belgium; (2) Belgian Poison Control Centre, Brussels, Belgium

256A study of verified spider bites in Slovenia Tanja Varl (1), Damjan Grenc (1), Rok Kostanjšek (2), Miran Brvar (1)

(1) University Medical Centre Ljubljana, Ljubljana, Slovenia; (2) University of Ljubljana, Ljubljana, Slovenia

257Antidote treatment in viper envenomation in Italy: a comparison of two antivenoms Davide Lonati (1), Azzurra Schicchi (1), Sarah Vecchio (1), Valeria M Petrolini (1), Eleonora Buscaglia (1), Giulia Scaravaggi (1), Carlo A Locatelli (1), Alberto Malovini (2)

(1) Pavia Poison Control Centre - National Toxicology Information Centre - Clinical and Experimental Lab, Toxicology Unit, Maugeri Clinical and Scientific Institutes IRCCS, and University of Pavia, Pavia, Italy; (2)

Informatic and Systemistic Laboratory for Clinical Research, Maugeri Clinical and Scientific Institutes IRCCS, Pavia, Italy

258Local envenoming from Western hognose snake bitesGillian Jackson (1), David Stewart (1), Caroline E McGrory (1), Sally M Bradberry (2), Simon HL Thomas (3), John P Thompson (4), Michael Eddleston (1), Euan A Sandilands (1)

(1) National Poisons Information Service (NPIS), Edinburgh, UK; (2) National Poisons Information Service (NPIS), Birmingham, UK; (3) National Poisons Information Service (NPIS), Newcastle, UK; (4) National Poisons Information Service (NPIS), Cardiff, UK

259Pain management in erucism: outcome in 286 cases from the Campinas Poison Control CenterMaíra MB Pimenta (1), Tais F Galvao (1), Marcus T Silva (2), Eduardo M De Capitani (1), Stephen Hyslop (1), Fabio Bucaretchi (1)

(1) State University of Campinas, Campinas, Brazil; (2) UNISO, Sorocaba, Brazil

260Safety of non-steroidal anti-inflammatory drugs in copperhead snakebite patientsHoang X Pham, Michael E MullinsWashington University School of Medicine, Saint Louis, US 261Severe and fatal envenomation by wandering spiders (genus Phoneutria) in Brazil: a review of literature reportsFabio Bucaretchi (1), Eduardo M De Capitani (1), Marlene Zannin (2), Rogerio Bertani (3), Stephen Hyslop (1)

(1) Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil; (2) Health Science Center, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil; (3) Butantan Institute, São Paulo, Brazil

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Animal poisoning (cont)

262Successful treatment of persistent ciguatera with intravenous mannitolMichael E Mullins, David B Liss, Anna M Arroyo-Plasencia, Evan S SchwarzWashington University School of Medicine, Saint Louis, US

263The EVEIT model as a means of improving the understanding of venom ophthalmiaDenise V Tambourgi (1), Marie Delafontaine (2), Claudia Panfil (3), Felix Spöler (4), Stefan Kray (4), François Burgher

(2), Laurence Mathieu (2), Joël Blomet (2), Norbert Schrage (3)

(1) Butantan Institute, São Paulo, Brazil; (2) Prevor, Valmondois, France; (3) ACTO, Aachen, Germany; (4) RWTH Aachen, Aachen, Germany

264The need of a second antivenom dose after snake bites by Vipera berusMark Personne, Peter HultenSwedish Poisons Information Centre, Stockholm, Sweden

265Thromboelastography in suspected Crotalus horridus horridus envenomationWilliam F Rushton (1), Michael Kurz (1), Justin Arnold (1), Nathan P Charlton (2)

(1) University of Alabama at Birmingham, Birmingham, US; (2) University of Virginia, Charlottesville, US

§ 266Venom-induced recurrent coagulopathy and hemorrhage in pregnancyElizabeth C Moore, Eleanor Oakley, Anne-Michelle RuhaBanner-University Medical Center Phoenix, Phoenix, US


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Animal poisoning (cont)

267Viperidae snakebites and antivenoms in central and southeastern European and neighbouring countries of Asia and Middle EastVid Leban (1), Laima Gruzdyte (2), Marius Perminas (3), Gabija Mikulevičienė (4), Piotr M Kabata (5), Jacek Anand (5), Wojciech Waldman (5), Ismail Afandiyev (6), Anna Krakowiak (7), Niko Bekjarovski (8), Blažena Caganova (9), Sergey Zakharov (10), Hossein Hassanian-Moghaddam (11), Horatiu Moldovan (12), Galina N Bashinskaya (13), Alexander Meister (14), Jasmina Jović-Stošič (15), Yury N Ostapenko (16), Barbara Nieradko-Iwanicka (17), Marine Grigoryan

(18), Ruth Kastanje (19), Csaba Pap (20), Vasil Atanasov (21), Margarita Gesheva (22), Anelia Loukova (22), Miroslava Petkova (22), Emilia Kirova (22), Julia Radenkova-Saeva (22), Igor Stoianov (23), Yanko Iliev (24), Senzha Zlateva (25), Evgenia Barzashka (26), Mojca Dobaja (1), Željka Babić (27), Igor Hrigorew (28), Miran Brvar (1)

(1) University Medical Centre Ljubljana, Ljubljana, Slovenia; (2) Poison Information Bureau of the Health Emergency Situations Centre of the Ministry of Health, Vilnius, Lithuania; (3) Lithuanian University of Health Sciences Kauno Klinikos, Kaunas, Lithuania; (4) The Center of Toxicology of Republican Vilnius University Hospital, Vilnius, Lithuania; (5) Clinical Toxicology Unit of Gdansk Medical University, Gdansk, Poland; (6) Center of Clinical Toxicology MoH, Baku, Azerbaijan; (7) Nofer Institute of Occupational Medicine, Łódź, Poland; (8)

University Clinic for Toxicology, Skopje, The Former Yugoslav Republic of Macedonia; (9) National Toxicological Information Centre, Bratislava, Slovakia; (10) Charles University and General University Hospital in Prague, Prague, Czech Republic; (11) Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran; (12) University of Medicine and Pharmacy of Târgu Mureș, Târgu Mureș, Romania; (13) City Hospital Number One, Astana, Kazakhstan; (14) Hospital Number One, Ust-Kamenogorsk, Kazakhstan; (15) Military Medical Academy, Belgrade, Serbia; (16) Research and Applied Toxicology Center of Federal Medical Biological Agency, Moscow, Russian Federation; (17) Medical University of Lublin, Lublin, Poland; (18) Yerevan State Medical University, Yerevan, Armenia; (19) Estonian Poisons Information Centre, Tallinn, Estonia; (20) Department of Toxicology Peterfy Hospital, Budapest, Hungary; (21) Bulgarian Society of Clinical Toxicology, Sofia, Bulgaria; (22) Toxicology Clinic, UMHATEM “Pirogov”, Sofia, Bulgaria; (23) UMHAT “Stoyan Kirkovich”, Stara Zagora, Bulgaria; (24) UMHAT “Sveti Georgi” Plovdiv, Plovdiv, Bulgaria; (25) Naval Military Medical Academy - Hospital Varna, Varna, Bulgaria; (26) UMHAT “Georgi Stranski”, Pleven, Bulgaria; (27) Institute for Medical Research and Occupational Health, Zagreb, Croatia; (28) Ministry of Health Republic of Belarus, Minsk, Belarus

268Two cases of tetrodotoxin poisoning from puffer fish consumption in TaiwanWan-Yin Kuo, Chien-Chin Hsu, Hung-Jung LinChi-Mei Medical Center, Tainan, Taiwan

Epidemiology of poisoning

269Accidental exposure to chemical compounds in Danish schools: a report from the Danish Poison Information CenterMargrethe B Sköld, Paula EC Hammer, Nete B Hansen, Niels E Ebbehøj, Ellen B PedersenCopenhagen University Hospital Bispebjerg, Copenhagen, Denmark

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Epidemiology of poisoning (cont)

270Acute phenobarbital poisoning: Moroccan Poison Control and Pharmacovigilance Centre data (2008-2014)Narjis Badrane (1,2), Fatima Abadi (1), Naima Rhalem (1,2), Ahlam Meftah (1), Abdelmajid Soulaymani (2), Rachida Soulaymani Bencheikh (1,3)

(1) Poison Control and Pharmacovigilance Centre of Morocco; Rabat, Morocco; (2) Laboratory of Genetics and Biometrics Ibn Tofail University, Kenitra, Morocco; (4) Faculty of Medicine and Pharmacy of Rabat, University Mohammed V Souissi, Rabat, Morocco

272Energy drink consumption patterns and knowledge of adverse effects amongst medical students, pharmacy students, pharmacists and residents in Québec, CanadaAlexandre Doucet, Éric Villeneuve, Sophie GosselinMcGill University, Montreal, Canada

273Epidemiology of poisonings by psychoactive substances in Russia Yury N Ostapenko (1), Igor Tiurin (2), Alexander Klyuev (2), Alexey Lodyagin (3), Valentin Sentsov (4), Elena Popova

(5), Alexander Sabaev (6), Alexander Shchupak (7), Vera Yukhno (7), Vladimir Kazachkov (1)

(1) Research and Applied Toxicology Center of Medical and Biological Agency of Russian Federation, Moscow, Russian Federation; (2) Moscow NV Sklifosovsky Research Institute of Emergency Aid, Moscow, Russian Federation; (3) St Petersburg II Dzhanelidze Research Institute of Emergency Aid, St Petersburg, Russian Federation; (4) Sverdlovsk Regional Psychiatric Hospital, Ekaterinburg, Russian Federation; (5) Krasnoyarsk State Professor V.F. Voino-Yasenetsky Medical University, Krasnoyarsk, Russian Federation; (6) City Clinical Hospital of Emergency Medical Aid No 1, Omsk, Russian Federation; (7) Far-Eastern State Medical University, Khabarovsk, Russian Federation

274Epidemiology of rattlesnake envenoming reported to an Arizona Poison CenterNicholas B Hurst, Jessica N Reilly, Keith J Boesen, Farshad M ShiraziArizona Poison and Drug Information Center, Tucson, US

275Fatal poisoning by pharmaceuticals and illicit drugs: comparison of cases reported to a Poisons Centre with official death certificatesMirjam Gessler (1), Cornelia Reichert (1), Christine Rauber-Lüthy (1), Christoph Junker (2), Hugo Kupferschmidt (1)

(1) National Poisons Centre, Tox Info Suisse, Associated Institute of the University of Zurich, Zurich, Switzerland; (2) Federal Statistical Office, Neuchâtel, Switzerland

276Fatalities due to acute intoxications from 2000 to 2015: a survey of the Poisons Information Centre AustriaAngelika Holzer, Ursula Schreiner, Sandra Hruby, Helmut Schiel, Tara ArifPoisons Information Centre, Vienna, Austria

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277Liver injury in acute poisoning in children: specific issues of etiology and evolutionCoriolan E Ulmeanu (1), Dora Boghitoiu (1), Viorela Nitescu (1), Alina Grama (2), Bogdan Bulata (2), Aurel Bizo (2)

(1) Pediatric Poisoning Centre Emergency Clinical Hospital for Children “Grigore Alexandrescu” Bucharest, Romania; (2) Pediatric Poisoning Centre Emergency Clinical Hospital for Children Cluj-Napoca, Cluj-Napoca, Romania

278Paediatric and adolescent poisoning in the Hunter region of AustraliaMichael A Downes, Caitlyn J Lovett, Geoffrey K IsbisterCalvary Mater Newcastle, Waratah, Australia

279Characterizing benzodiazepine toxicities using the Toxicology Investigators Consortium (ToxIC) RegistryKristin McCloskey, Ryan Surmaitis, David Goldberger, Rita McKeeverDrexel University College of Medicine, Philadelphia, US

Household products poisoning

281Acute poisoning in children with concentrated laundry detergent capsulesLylia A Kovalenko (1), Yury N Ostapenko (2), Galina N Sukhodolova (3), Alexander S Kovalchuk (1)

(1) Children Poisoning Treatment Center, Moscow, Russian Federation; (2) Research and Applied Toxicology Center, Moscow, Russian Federation; (3) The Chair of Reanimatology and Intensive Therapy, Moscow, Russian Federation

282Characterization of endoscopic findings following ingestion of liquid laundry detergent packet products as reported to US poison centersWilliam Banner (1), Ryan Lucas (2), Kate M Reynolds (2), Jody L Green (2)

(1) Oklahoma Center for Poison and Drug Information, Oklahoma City, US; (2) Rocky Mountain Poison and Drug Center, Denver, US

283Circumstances of liquid laundry pod exposure: a prospective study based on calls to the French Poison Control CentersSandra Sinno-Tellier (1), Fatoumata Rigaux-Barry (2), Laurie Cordier (3), Anne-Marie Patat (4)

(1) French Agency for Food, Environmental and Occupational Health and Safety, Maisons-Alfort, France; (2)

Poison Control Centre of Nancy, University Hospital, Nancy, France; (3) Poison Control Centre of Toulouse, University Hospital, Toulouse, France; (4) Poison Control Centre of Lyon, University Hospital, Lyon, France

284Exposures to automatic dishwashing detergents examined by an Italian Poison Control CenterAnna Celentano, Fabrizio M Sesana, Beatrice Giliotti, Leonardo Molino, Joannhe Georgatos, Marcello Ferruzzi, Franca DavanzoMilan Poison Control Center, Milan, Italy

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285Ocular exposures to household detergents and cleaning products Anna Celentano, Fabrizio M Sesana, Marcello Ferruzzi, Marco Morina, Valeria Dimasi, Franca DavanzoMilan Poison Control Center, Milan, Italy

286Paediatric poisonings from ethanol-based household products: a review of enquiries to the New Zealand National Poisons Centre, 2003-2015Mette G Goodin, Yvette C MillardNational Poisons Centre, University of Otago, Dunedin, New Zealand

Mechanisms of toxicity and basic research

287Effects of insulin on statin-induced myopathy and insulin resistanceGerda M Sanvee, Jamal Bouitbir, Stephan KrähenbühlClinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland

288Electroencephalographic patterns of lithium poisoning: a study of the effect/concentration relationships in the ratAnne-Sophie Hanak (1), Isabelle Malissin (2), Joel Poupon (3), Patricia Risède (1), Lucie Chevillard (1), Bruno Megarbane (2)

(1) INSERM UMRS-1144, Paris-Descartes & Paris-Diderot Universities, Paris, France; (2) Department of Medical and Toxicological Critical Care, Lariboisière Hospital, Paris, France; (3) Laboratory of Toxicology, Lariboisière Hospital, Paris, France

289Mechanisms of cytotoxicity involved in metamizole-induced neutropeniaDeborah Rudin, Manuel Haschke, Stephan KrähenbühlClinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland

290Neurobehavioral effects of lithium in the rat: an investigation of the effect/concentration relationships and the contribution of the poisoning patternAnne-Sophie Hanak (1), Bruno Megarbane (2,3), Lucie Chevillard (1), Rodolphe Lebeau (1), Patricia Risède (1), Jean-Louis Laplanche (1), Nadia Benturquia (1)

(1) Paris-Descartes & Paris-Diderot Universities, Paris, France; (2) INSERM UMRS-1144, Paris-Descartes & Paris-Diderot Universities, Paris, France; (3) Department of Medical and Toxicological Critical Care, Lariboisière Hospital, Paris, France

291Neuro-respiratory toxicity of baclofen in the rat: study of the concentration/effect relationships and role of GABAergic receptorsSalma Tannous (1), Lucie Chevillard (1), Laurence Labat (1), Patricia Risède (1), Isabelle Malissin (2), Bruno Megarbane (3,4)

(1) Paris-Descartes & Paris-Diderot Universities, Paris, France; (2) Lariboisière Hospital, Paris, France; (3) INSERM UMRS-1144, Paris-Descartes & Paris-Diderot Universities, Paris, France; (4) Department of Medical and Toxicological Critical Care, Lariboisière Hospital, Paris, France

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Mechanisms of toxicity and basic research (cont)

292Tramadol-related neurotoxicity in the rat: contributions of the different neuromediators and effects of potential antidotesHao Liang (1), Camille Lagard (1), Lucie Chevillard (1), Jacques Callebert (1), Patricia Risède (1), Bruno Megarbane (2)

(1) INSERM UMRS-1144, Paris-Descartes & Paris-Diderot Universities, Paris, France; (2) Department of Medical and Toxicological Critical Care, Lariboisière Hospital, Paris, France

Plant and mushroom poisoning

293A severe intoxication after ingestion of an infusion prepared with seeds bought over the InternetMarco Morina, Anna Celentano, Paolo Severgnini, Ilaria Rebutti, Franca Davanzo, Maurizio BissoliMilan Poison Control Center, Milan, Italy

294Aconite: rare but potentially serious poisoningFrancis Grossenbacher (1), Emmanuel Puskarczyk (2), Pierre Etienne Colot (3), Camille Richeval (4), Jean Michel Gaulier (4), Helene Marty (5), Jacques Manel (2)

(1) University Hospital Reims, Reims, France; (2) Poison Center Control Nancy, Nancy, France; (3) Emergency Department, University Hospital Reims, Reims, France; (4) Toxicology and Pharmacology Department, University of Lille, Lille, France; (5) Toxicology and Pharmacology Department Reims, Reims, France

295Amanita phalloides poisoning in Slovenia, 1999- 2015Andreja Vendramin, Marija Jamsek, Miran BrvarUniversity Medical Centre Ljubljana, Ljubljana, Slovenia

296Anticholinergic toxicity associated with ingestion of water containing lupini bean extractKai Li (1), Xander Van Wijk (2), Sandra Hayashi (1), Craig Smollin (1)

(1) California Poison Control Center, San Francisco, US; (2) University of California, San Francisco, US

297Case report: a relaxing cup of poppy seed tea goes toxicGinger Rinner, Chelsea C White, Susan C Smolinske, Brandon J WarrickUniversity of New Mexico, Albuquerque, US

298Cerbera manghas intoxication: a case reportHon-Pheng Tam, Si-Chon Vong, Chien-Chin Hsu, Hung-Sheng HuangChi Mei Medical Center, Liouying, Taiwan

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Plant and mushroom poisoning (cont)

299Cerbera odollam poisoning in the western world: a potentially serious public health epidemicHenry Fok (1), Punitha Victor (1), Sally M Bradberry (2), Michael Eddleston (1)

(1) National Poisons Information Service, Edinburgh, UK; (2) National Poisons Information Service, Birmingham, UK

300Classic appearances of aconitine intoxication: do physicians recognize the signs?Hung-Sheng Huang (1), Chien-Chin Hsu (1), Chia-Hsien Huang (2)

(1) Chi-Mei Medical Center, Tainan, Taiwan; (2) Ministry of Health and Welfare Pingtung Hospital, Pingtung County, Taiwan

301Colchicum autumnale or why autumn may be dangerous even if you are not depressedStefan Poechacker (1), Nina Grossmann (1), Julia Schuch (1), Fred Radunsky (1), Wolfgang Bicker (2)

(1) Wilhelminenspital, Vienna, Austria; (2) FTC Forensic Toxicologic Laboratories, Vienna, Austria

302Enquiries to a poisons information service concerning sycamore (Acer pseudoplatanus)Alison M Good (1), Gillian Jackson (1), Caroline E McGrory (1), Simon HL Thomas (2), John P Thompson (3), Sally M Bradberry (4), Euan A Sandilands (1)

(1) NPIS Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK; (2) NPIS Newcastle, Regional Drug and Therapeutics Centre, Newcastle upon Tyne, UK; (3) NPIS Cardiff, University Hospital Llandough, Cardiff, UK; (4)

NPIS Birmingham, City Hospital, Birmingham, UK

303Erycibe henryi-induced acute cholinergic syndromeHan-Wei Mu, Dong-Zong HungDivision of Toxicology, China Medical University Hospital, Taichung, Taiwan

304Gastrointestinal toxicity and acute kidney injury following ingestion of suspected Amanita ochrophyllaDarren M Roberts (1), Colin B Page (2)

(1) Sydney Children’s Hospital Network, Sydney, Australia; (2) Princess Alexandra Hospital, Brisbane, Australia

305Suicide attempt by infusion of rotenone-containing plant extracts: a case report from French PolynesiaRomain Torrents, Corinne Schmitt, Mathieu Glaizal, Bastien Domange, Katarina Moenikes, Susanna Davoust, Audrey Boulamery, Luc De Haro, Nicolas SimonAPHM, Hôpitaux Sud, Marseille, France

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Poisoning management (including pre-hospital management)

306Methanol poisoning inadvertently treated with vodka via intravenous administrationElizabeth C Moore, Will Heise, Maureen Roland, Belinda Sayers, Daniel E BrooksBanner Poison and Drug Information Center, Phoenix, US

307Acute beta-blocker overdose management: factors associated with cardiovascular mortality in a Caribbean intensive care unitDabor Resiere (1), Ruddy Valentino (1), Cyrille Charbatier (1), Joceyn Inamo (1), Bruno Megarbane (2), Hossein Mehdaoui (1)

(1) University Hospital of Martinique, Fort-de-France, France; (2) Lariboisière Hospital, Paris, France

308Advances in a knowledge-based decision support system for the diagnosis of human toxic exposuresJoel D Schipper (1), Jay L Schauben (2), Douglas D Dankel II (3)

(1) Embry-Riddle Aeronautical University, Prescott, US; (2) Florida/USVI Poison Information Center; University of Florida Health Science Center, Jacksonville, US; (3) University of Florida, Gainesville, US

309An outbreak of foodborne botulism due to stuffed pizza with olivesFrancesco Gambassi (1), Angelo Rotulo (1), Fabrizio Anniballi (2), Bruna Auricchio (2), Dario De Medici (2), Davide Lonati (3), Carlo Locatelli (3), Irene Campolmi (4), Francesca Rinaldi (4), Michele Spinicci (4), Emanuela Masini (5)

(1) Toxicology Unit and Poison Control Center, AOU Careggi, Florence, Italy; (2) National Reference Center for Botulism, Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Rome, Italy; (3)

Pavia Poison Centre and National Toxicology Information Centre, IRCCS Maugeri Foundation Clinical Institute and University of Pavia, Pavia, Italy; (4) Infectious and Tropical Disease Unit, AOU Careggi, Florence, Italy; (5) Toxicology Unit and Poison Control Center, AOU Careggi; Department of NEUROFARBA, University of Florence, Florence, Italy

310Appropriateness of assessment of acute recreational drug toxicity in onsite nightclub medical facilitiesMatthew S Blundell, Mark Haden, Paul I Dargan, John RH Archer, David M WoodGuy’s and St. Thomas’ NHS Foundation Trust, London, UK

311Avoidable management errors in acute salicylate poisoningMichael E MullinsWashington University School of Medicine, Saint Louis, US

312Dexmedetomidine for alcohol withdrawal: looks can be deceivingMorgan AA Riggan (1), Mark K Su (2), Robert S Hoffman (1)

(1) NYU School of Medicine, New York, US; (2) New York City Poison Control Center, New York, US

313Does a patient with severe aluminum phosphide intoxication pose a danger to healthcare providers?Marianne EC Leenders, Claudine C Hunault, Irma de VriesUniversity Medical Center Utrecht (UMCU), Utrecht, The Netherlands

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Poisoning management (including pre-hospital management) (cont)314Effect of extracorporeal treatments in a patient with prolonged phenytoin toxicityDarren M Roberts (1), Tina Xu (2), Colin B Page (3)

(1) Royal Prince Alfred Hospital, Sydney, Australia; (2) The Canberra Hospital, Canberra, Australia; (3) Princess Alexandra Hospital, Brisbane, Australia

315Glucose-6-phosphate hydrogenase (G6DP) deficiency induced by 6-aminonicotinamide in hepatocytes: a protective factor in phosphine exposureNasim Zamani, Maryam Paeezi, Hossein Hassanian-Moghaddam, Shahin Shadnia, Jalal PourahmadShahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran

316Hyperbaric treatment for hydrogen peroxide poisoning associated with portal venous gas and neurological symptoms: a case reportBarak Levit (1), Yael Lurie (1), Igor Markovich (1), Anna Bloom Krasik (1), Ronen Bar (2), Yedidia Bentur (1)

(1) Rambam Health Care Campus, Haifa, Israel; (2) Israel Naval Medical Institute, Haifa, Israel

317Management of a mixed overdose in the prehospital setting: a case reportEric Villeneuve (1), Marie-Soleil Delisle (1), Josh J Wang (2), Sophie Gosselin (1)

(1) McGill University Health Centre, Montreal, Canada; (2) McGill Faculty of Medicine, Montreal, Canada

318Metformin poisoning in the intensive care unit: a clinical, prognostic and pharmacokinetic studyNicolas Péron (1), Bruno Megarbane (1-3), Xavier Declèves (2), Christophe Bardin (2), Lucie Chevillard (3), Isabelle Malissin (1), Nicolas Deye (1), Sebastian Voicu (1)

(1) Department of Medical and Toxicological Critical Care, Lariboisière Hospital, Paris, France; (2) Laboratory of Toxicology, Cochin Hospital, Paris, France; (3) INSERM UMRS-1144, Paris Descartes & Paris-Diderot Universities, Paris, France

319Need hemodialysis? Only during business hours!Mark K Su (1), Robert S Hoffman (2), Ian Julie (3), Pui Y Chan (4), Sung W Lim (4), Sage Wiener (5)

(1) New York City Poison Control Center, New York, US; (2) New York University, New York, US; (3) UC Davis, Sacramento, US; (4) New York City DOHMH, New York, US; (5) SUNY Downstate Medical Center, Brooklyn, US

320Outcome of intoxicated patients admitted to the Intensive Care Unit (TOXIC study)Irma S Van den Hengel-Koot (1), Saskia J Rietjens (1), Douwe Dekker (2), Karin AH Kaasjager (2), Irma de Vries (1), Dylan W De Lange (1,3), Laura Hondebrink (1)

(1) Dutch Poisons Information Center (DPIC), University Medical Center Utrecht (UMCU), Utrecht, The Netherlands; (2) Department of Internal Medicine, UMCU, Utrecht, The Netherlands; (3) Department of Intensive Care Medicine, University Medical Center Utrecht (UMCU), Utrecht, The Netherlands

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CONGRESS SUPPORTERS AND SPONSORS

FRIDAY 19 MAY 2017

Poisoning management (including pre-hospital management) (cont)321Poisons information at the frontline: use of the TOXBASE app by UK ambulance service staff in the pre-hospital settingDavid J Lupton (1), Lindsay D Gordon (1), Gillian Jackson (1), Sally M Bradberry (2), John P Thompson (3), Simon HL Thomas (4), Euan A Sandilands (1)

(1) NPIS Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK; (2) NPIS Birmingham, City Hospital, Birmingham, UK; (3) NPIS Cardiff, University Hospital Llandough, Cardiff, UK; (4) NPIS Newcastle Regional Drug and Therapeutics Centre, Newcastle upon Tyne, UK

322Protective effect of erythropoietin in visual disturbances due to methanol poisoning: a preliminary reportNasim Zamani, Hossein Hassanian-Moghaddam, Shahin ShadniaShahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran

323Recalled to life: prolonged action of pancuronium in a neonate suggesting death reversed with neostigmineSian CD Harbon, John P Thompson, James M CoulsonUK National Poisons Information Service, Cardiff, UK

324Suicide attempt with acetonitrile treated with sodium thiosulfate: a case reportEduardo M De Capitani, Carla F Borrasca-Fernandes, Maíra Branco, Rafael Lanaro, Jose Luis Costa, Sueli M Mello, Helena Nóbrega, Fábio BucaretchiState University of Campinas, Campinas, Brazil

325Update after 20 years of take home naloxone programsThomas MartinTexas Tech University, Amarillo, US

326When an international vacation almost kills your teenager: case report of severe Bothrops asper envenomation of an American teenager while in Belize with common and not so common manifestationsBenjamin N Abo (1), Spencer Johnson (1), Scott R Mullin (2)

(1) University of Florida, Gainesville, US; (2) Miami Dade Fire Rescue, Miami, US

327When new therapies fail and old therapies are forgotten: a case of a late nortriptyline death with failed lipid emulsion therapy Morgan AA Riggan, Rana Biary, Robert S Hoffman, Daniel M LugassyNYU School of Medicine, New York, US

192Acute tenofovir overdose causes benign symptoms: a case series Lovisa Östberg, Jonas HöjerSwedish Poisons Information Centre, Stockholm, Sweden

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The EAPCCT gratefully acknowledges support from the following organisations:


Federal Office of Public Health, Switzerland

SCAHT - Swiss Centre for Applied Human Toxicology

The member companies of the KGF (Kontaktgruppe für

Forschungsfragen), BASF, F. Hoffmann-La Roche AG,

Novartis and Syngenta

Fundación Española de Toxicología Clínica fe

otc

fundación española de toxicología clínica

Kanton Basel-Stadt

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The EAPCCT gratefully acknowledges support from the following exhibitors:


Taylor & Francis Group

Flynn Pharma

Laboratoires SERB

Prevor

Truven Health Analytics. IBM Watson Health R

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www.eap

cct.org

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pcc

t20

17


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ont

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tici

de

toxi

colo

gy

Toxicological analysis and contribuon to diagnosis and paent management in clinical toxicology

EAPC

CT 2

017

37th

Con

gress

of the

Europ

ean A

ssocia

tion

of Po

isons

Cen

tres a

nd C

linica

l Tox

icolog

ists

PR

OG

RA

MM

E A

T A

GL

AN

CE

www.eap

cct.org

#ea

pcc

t20

17

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