development and evaluation of xyloglucan matrix release tabs contaning glipizide

8/7/2019 Development and Evaluation of Xyloglucan Matrix release tabs contaning Glipizide

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\_IJGNV

^VE_V


7/26

FGSGHI\BGMV EMF

GSEHWEVKIM IC

P[HIDHWNEM BEV_KP

_GHGE^GVEOHGV^

NIMVEKMKMD DHK\KZKFG

\rijgnv ~wobkvvgf viEn`er{e Mederjwme Wmksgr~kv{( Dwmvwr-

FG\E_VBGMV IC \@E_BENGWVKN^ SKNVI_KE NIHHGDG IC

\@E_BEN[

Wmfgr v`g dwkfemng ic

Br- \- Erwm Awber ( B-\`erb-(


8/26

Iojgnvksg \rg|erg emf gsehwevg bevrkp veohgv~ ic dhk|kzkfg w~kmd P[HIDHWNEM e~ e

|ih{bgr-

\hem ic tira

Gpvrenvkim ic p{hidhwnem

\rg|erevkim ic bevrkp rghge~g veohgv~

Gsehwevkim ic |rg|ergf bevrkp veo~

_g~whv~ emf fk~nw~~kim


\@E_BEN[


9/26

Dhk|kzkfg

Ireh emvk fkeogvkn edgmv oghimdkmd vi ~wh|`im{h wrge~ nhe~~-

Kv k~ km~ihwohg km tevgr emf ehni`ih~( ~ihwohgkm


10/26

Kmvrifwnvkim ^w~vekmgf rghge~g v`gir{ : Bifkckgf rghge~g) mim"kbbgfkevg"rghge~g fghksgr{ ~{~vgb~ tgrg fgsghi|gf emf be{ og

fkskfgf kmvi ciwr nevgdirkg~:

5-Fghe{gf rghge~g

?-^w~vekmgf rghge~g

E+Nimvrihhgf rghge~g

O+\rihimdgf rghge~g >-^kvg"~|gnkckn rghge~g

6-_gng|vir rghge~g

Cir mim kbbgfkevg rghge~g fi~edg cirb( Ar888Ae( v`ev k~( rghge~g ic frwd crib v`g fi~edg

cirb k~ v`g revg " hkbkvkmd ~vg|- V`k~ new~g~ v`g eoisg akmgvkn vi rgfwng v`g cihhitkmd:

BEV_KP

_GHGE^G

VEOHGV^

Fi~edg cirb Ar Verdgv erge Ag

Frwd rghge~g Ghkbkmevkim


\@E_BEN[


11/26

Bgn`emk~b ic frwd rghge~g E ~grkg~ ic vrem~|irv |`gmibgme erg kmsihsgf km v`g rghge~g ic e frwd crib e

~tghheohg( fkccw~kim)grifeohg bevrkp:

Kmkvkehh{( v`grg erg ~vgg| tevgr nimngmvrevkim drefkgmv~ ev v`g |ih{bgr)tevgr kmvgrceng(

rg~whvkmd km eo~ir|vkim ic tevgr kmvi v`g bevrkp

Fwg vi v`g eo~ir|vkim ic tevgr( v`g |ih{bgr ~tghh~( rg~whvkmd km frebevkn n`emdg~ ic

frwd emf |ih{bgr nimngmvrevkim( kmnrge~kmd v`g fkbgm~kim~ ic v`g ~{~vgb emf

kmnrge~kmd benribihgnwher biokhkv{

W|im nimvenv tkv` tevgr v`g frwd fk~~ihsg~ emf fkccw~g~ iwv ic v`g fgskng-

Tkv` kmnrge~kmd tevgr nimvgmv( v`g fkccw~kim nigccknkgmv ic v`g frwd kmnrge~g

~wo~vemvkehh{

Km v`g ne~g ic e |iirh{ tevgr"~ihwohg frwd( fk~~ihsgf emf wmfk~~ihsgf frwd nigpk~v

tkv`km v`g |ih{bgr"bevrkp

Ckmehh{( v`g |ih{bgr kv~ghc fk~~ihsg~


12/26

Gccgnv ic revg hkbkvkmd |erebgvgr~ \ih{bgr `{frevkim

Frwd ~ihwokhkv{

^ihwvkim ~ihwokhkv{

\ih{bgr fkccw~kskv{

e+ \ih{bgr |ervknhg ~kzgo+ \ih{bgr sk~ni~kv{

n+ \ih{bgr nimngmvrevkim

V`knamg~~ ic |ih{bgr fkccw~kimeh |ev`

V`knamg~~ ic `{frif{mebkn fkccw~kim he{gr

Frwd hiefkmd fi~g

^wrceng erge emf sihwbg

Fkhwgmv~ gccgnv

Effkvksg~


13/26

Gpvrenvkim ic P{hidhwnem

?< db ic veberkmf agrmgh |itfgr

Effgf vi ?


14/26

\rg|erevkim ic bevrkp veo~

PDH 5 PDH? PDH> PDH6 PDH7

Dhk|kzkfg 5


15/26

-

\ringfwrg Veohgv~ tgrg |rg|ergf o{ tgv dremwhevkim vgn`mkuwg-

^vern` bwnkhedg e~ okmfgr( henvi~g e~ fkhwgmv emf bkpvwrg ic vehn emf bedmg~kwb

~vgrevg e~ hworknemv-

P{hidhwnem( @\BN( NE\( GN tgrg kmnhwfgf km v`g cirbwhevkim~ nimvekmkmd 5


16/26

\rgcirbwhevkim ~vwfkg~

CVK_ IC DHK\KZKFG


17/26

CVK_ IC DHK\KZKFG ! P[HIDHWNEM


18/26

G~vkbevkim Nim~vrwnvkim ic ^vemferf nwrsg ic Dhk|kzkfg

E

o

~

i

r

o

e

m

ng

Nimngmvrevkim d)bh+

^h-

Mi

Nimngmvrevkim ( d)bh+ Eo~iroemng km


19/26

Fk~~ihwvkim ^vwfkg~

VKBG Km @iwr~+

'

F

r

w

d

r

g

h

g

e~

g

C5 cibwhevkim

gp`kokv~ ;; ' frwd

rghge~g cir |rihimdgffwrevkim-


20/26

VKBG `r+ C5 C? C> C6 C7

< < < < < ?5 3-735 ;-356 3-756 0-?63

? 5;-73> 5>-6?0 54->?0 57->?5 57-?75

> >->?6 ?3-65? ?>-653 ?7-56>

6 6?-656 >5-373 >6-737 >?-53? >>->7;

7 70-75? >;-77? 6-077 63-5?6 6;-73 7?-;53 6;-?>44 06-335 3>-430 77-5?0 35-5?> 74-7;5

0 ;7-3?? 4;-05? 36->?7 46-47? 33-503

NIB\E_K^IM IC FK^^IHWVKIM _EVG^


21/26

\`{~kneh |erebgvgr~


\@E_BEN[


22/26

Fk~nw~~kim Km v`k~ ~vwf{( dhk|kzkfg bevrkp veohgv~ bgv v`g |èrbeni|igkeh rguwkrgbgmv ic wmkcirbkv{

ic tgkd`v-

Ehh v`g veohgv~ nimcirbgf vi v`g rguwkrgbgmv ic e~~e{( e~ |gr K-\- èrfmg~~( ' crkeokhkv{(

emf v`knamg~~ tgrg tghh tkv`km enng|veohg hkbkv~-

Kv è~ oggm io~grsgf vèv v`g nwbwhevksg |grngmv frwd rghge~g fgnrge~g~ tkv` kmnrge~kmd

nimngmvrevkim ic dwb emf ~tghhkmd kmfgp-

Kmnrge~kmd v`g ebiwmv ic dwb km v`g cirbwhevkim( rg~whvgf km ~hitgr revg( emf fgnrge~gf

ebiwmv ic frwd rghge~g crib v`g veohgv-

^veokhkv{ ~vwfkg~ rgsgehgf vèv v`grg te~ mi ~kdmkcknemv nèmdg km èrfmg~~( crkeokhkv{(

frwd nimvgmv emf fk~~ihwvkim |rickhg~ ic C5-

î( C5 cirbwhevkim niwhf og w~gf e~ em gccgnvksg bevrkp cirbgr( vi rgverf v`g rghge~g ic

dhk|kzkfg cir gpvgmfgf |grkif ic vkbg-


\@E_BEN[


23/26

Nimnhw~kim Km v`g |rg~gmv tira gccirv~ èsg oggm befg vi cirbwhevg emf n`gnakmd ic frwd rghge~g

ogèskir ic p{hidhwnem bevrkp veohgv~

Ehh v`g cirbwhevkim~ tgrg gp`kokvgf emibehiw~ fkccw~kim bgnèmk~b emf C5 cirbwhevkim

te~ ciwmf vi og v`g og~v cirbwhevkim im v`g vrekh emf grrir bgvìf emf kv te~ ~ghgnvgf

cir w~g e~ ~w~vekmgf bevrkp rghge~g veohgv~

Ckmehh{( v`g og~v cirbwhevkim C5 frwd rghge~g km serkiw~ enkfkn emf oe~kn owccgr~( v`g

frwd rghge~g te~ fg|gmfgmv im imh{ |ih{bgr nimngmvrevkim~-


24/26

Okohkidre|`{ Mkn`ihe~ D-hirfk(~w~vekmgf rghge~g fi~edg cirb km v`g v`gir{ emf |renvkng ic kmfw~vrkeh

|`erben{h- Hen`bem(`- E- Hkogrbem( emf j- H- Aemkd( gf~( hge # cgokdgr+( |`khefgh|`ke(|e(

5;03+( kkkrf gfkvkim-(6>


25/26

J- Nrema( v`g bev`gbevkn~ ic fkccw~kim( ipcirf wmksgr~kv{ |rg~~( ipcirf 5;73+-

Edk~ a{fimkgw~( vrgevk~g im nimvrihhgf frwd fghksgr{ berngh fgaagr( kmn: ?73"?;

development and evaluation of xyloglucan matrix release tabs contaning glipizide

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