development of nanomedicine in hong kong

79 Sunday, September 10th (2:10)

Concurrent Symposium XVI: International Nanomedicine

Development

Nanomedicine Research in China

Zhao X, PhD, Institute for NanoBiomedical Technology and Membrane

Biology, West China Hospital, Sichuan University, Chengdu, China

Abstract is not available.

doi:10.1016/j.nano.2006.10.090



Development

Development of nanomedicine in Hong Kong

Wong K, Hong Kong University, Hong Kong

Nano-biotechnology, an interdisciplinary science, combines physical laws,

chemical procedures and biological principles on the nano-scale. The

recent establishment of the nano-biotechnology group in the University of

Hong Kong has been seen as the first step in the direction of advancing

research in this field. The group has identified eight topics in which the

University has proven research strengths, and will be seeking to develop

these topics to internationally-competitive levels. Four teams have been

looking into DNA electronics, microfluidic devices for disease monitor-

ing, the use of nano-metals/metal compounds for clinical applications, and

the use of bio-polymeric materials for drug delivery. A fifth team is

developing techniques to exploit manganese ferrite magnetic nanoparticles

by using them as contrast agents in magnetic resonance imaging (MRI)

examinations; and to use lanthanide oxide nanoparticles as probes to

detect bio-macromolecules. A sixth team is developing nanoindentation

technologies for measuring the microstructures of biological tissues. A

seventh team is looking at cellular and subcellular mechanics. Finally, an

eighth team is exploiting recent advances in electrospinning technology to

developing nano- and micro-fibres for tissue engineering applications.

With inter-department and international collaboration, we hope to help

advance and expand nano-medicine in our community, as well as globally.

Dr. Kenneth Wong is currently clinical assistant

professor in the Department of Surgery, University

of Hong Kong. A graduate of the University of

Edinburgh, UK, he received his clinical training in

UK before embarking on lab-based research. He

obtained his Ph.D in immunology from Imperial

College, UK. Dr. Wong’s research interests include

genetic basis of paediatric surgical diseases and

tumor immunobiology. On the basic science front, He has been focusing

on the use of nano-metals in wound healing and targeted chemotherapy

against tumors.

doi:10.1016/j.nano.2006.10.091



Development

Status of nanomedicine research in India

Jain NK, Department of Pharmaceutical Sciences, Dr. H.S.Gour University,

Sagar, India

Nanomedicine is the medical application of Molecular nanotechnology

(MNT)—a still developing science dedicated to constructing microscopic

biomechanical devices like nanomechines and nanorobots. We being one of

the pioneers in the field of Nanotechnology and Nanomedicine research in

India, started the work in the field of drug delivery in early 90’s by employing

dendritic nano architecture for the controlled and targeted delivery of

anticancer bioactives. Many other laboratories in India immediately took up

this work and soon reports of dendrimer based delivery of bioactives started

pouring out. Polymer based nanoparticles holds tremendous promise in the

field of tissue targeted drug delivery and apart from our own research group

several other CSIR labs in India like Central Drugs Research Institute

(CDRI), Lucknow, Indian Institute of Chemical Biology (IICB), Calcutta are

working on targeting of antileichmanial and antimalarial drugs by means of

engineered nanoparticles for the effective management of malaria and

leishmaniasis. A lot of work is going on mitochondrial drug targeting in

several laboratories in India including our Lab. Dr. Reddy’s Research

Foundation, Biocon India Ltd., Bangalore and Hyderabad based Santa

Biotech are currently in the race to develop various nano carriers for the

delivery of therapeutic proteins and immunomodulators. Our group is

engaged in gene therapy of genetic disorders like diabetes and cancer using

dendrimer based nano carriers. Similar works are also in progress in

Hyderabad based Center for Cellular and Molecular Biology (CCMB) Dr.

Shyamal Roy of Indian Institute of Chemical Biology, Calcutta is currently

engaged in developing a DNAvaccine against Leichmania donovani. A lot of

similar work is also going on in Indian Institute of Microbial Technology

(IIMTech), Chandigarh, National Institute of Immunology (NII), New Delhi

and five Indian Institute of Technologies (IIT). Stem cell research is currently

in progress in the All India Institute ofMedical Sciences (AIIMS), NewDelhi

and the premier medical research institute in India is expected to deliver some

path breaking results in this field. Recently, in a landmark research

agreement with international dimensions India’s premier science and

technology research organizations, including the Department of science

and technology (DST), Department of Biotechnology (DBT), Council of

Scientific and Industrial Research (CSIR) have signed a 5 year agreement

with the University of California system to carry out ground breaking

in globally challenging and impactful areas including nanotechnology

and nanomedicine.

Professor N.K. Jain earned B.Pharm; M.Pharm; Ph.D

from Sagar University, India. He published over 250

research papers, review articles and other popular

articles. He successfully guided 22 Ph.D. and 60

M.Pharm. candidates. Dr. Jain completed 10 major

research projects (UGC, CSIR, MHRD) and two book-

writing project. He is an author of 12 popular books in

pharmacy. His research interests include Hydrotropic

Solubilization of Drugs, Treatment strategies for Helicobacter pylori,

Controlled and Novel Drug Delivery Systems including dendrimers,

nanoparticles, resealed erythrocytes etc. Referee — all leading national

and international pharmaceutical journals. He won several awards in

teaching and research and filed 2 US patents. His teaching experience —

total 33 years including 20 years as full-fledged professor. He has been

Head of the Department, Dean of Faculty, Principal of Colleges etc.

doi:10.1016/j.nano.2006.10.092



Development

America—Japan Nanomedicine Society (AJNS)

Urisu T, Wei C, Institute for Molecular Science, Myodaiji, Okazaki, Japan,

Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA

Importance of the new interdisciplinary academic field bNanomedicineQwas pointed out in the Roadmap of NIH (The National Institute of Health)

issued at 2003. Really the boundary between the material science and the

medical science and even the medical treatments has been becoming

extremely vague, after the complete sequencing of the human genome.

Abstracts / Nanomedicine: Nanotechnology, Biology, and Medicine 2 (2006) 269–312 297

http://dx.doi.org/10.1016/j.nano.2006.10.090



development of nanomedicine in hong kong

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