diagnostic accuracy of rubidium-82 myocardial perfusion imaging using pet ct
TRANSCRIPT
• Diagnostic Accuracy of Rubidium-82 Myocardial
Perfusion Imaging using PET CT
• Diagnostic Accuracy of Rubidium-82 Myocardial
Perfusion Imaging using PET CT
Normal Rubidium-82 Myocardial Perfusion PET-CT Study
Abnormal Rubidium-82 Myocardial Perfusion PET-CT Study
Limitations
Limitations• May underestimate the anatomical extent of
CAD in some patients with multivessel disease.
• Subclinical vessel disease may have normal perfusion studies.
• Not all patients with normal perfusion study get CTA or Cath. Adds bias to the true Negative group
• May underestimate the anatomical extent of CAD in some patients with multivessel disease.
• Subclinical vessel disease may have normal perfusion studies.
• Not all patients with normal perfusion study get CTA or Cath. Adds bias to the true Negative group
Advantage of ECG-gated PET
• Assess LV function at rest and during peak stress
• Healthy pts: LVEF increases during peak vasodilator stress
• Patients with left main or 3 vessel CAD show decrease in LVEF at peak stress even in the absence of perfusion abnormalities
Sensitivity
• 93% in single vessel disease.• 92% in multivessel disease.
• May have a slight bias as many normals don’t have correlative coronary angiography.
• MDCT angiography shows high degree of correlation with Rubidium-82 Myocardial Perfusion PET-CT.
Integrated PET/CTA study
Integrated PET/CTA study:
• Noncalcified plaque (arrow) in proximal LAD with 50%–70% stenosis. However, rest and peak stress myocardial perfusion PET study (bottom left panel) demonstrates only minimal inferoapical ischemia.
Conclusion
• Myocardial perfusion PET-CT :• high sensitivity for detection of CAD. • applicable to both men and women,
nonobese and obese patients.• Patients with single-vessel as well as
multivessel coronary disease. • Rest and stress imaging is completed in
approximately 25 min.
• Myocardial perfusion PET-CT :• high sensitivity for detection of CAD. • applicable to both men and women,
nonobese and obese patients.• Patients with single-vessel as well as
multivessel coronary disease. • Rest and stress imaging is completed in
approximately 25 min.
Fast