Drug Name Classification Mechanism of Action Contraindication Adverse Effect Nursing Consideration

Generic Name:Diclofenac Sodium

Brand Name:Voltaren, Fenac

NonsteroidalAnti-Inflammatory drug

Unknown, May inhibit prostaglandin synthesis to produce anti-inflammatory, Analgesic, and antipyretic effects.

Contraindicated in patient hypersensitive to drug and in those with hepatic porphyria or history ofAsthma, urticarial, or other allergic reactions after taking aspirin or other NSAIDSs.

Drug isn’t recommended for using during late pregnancy or breast- feeding

Use cautiously in patients with history of peptic ulcer disease , hypertension, fluid retention

CNS: Anxiety , depression, dizziness, drowsiness, insomnia, irritability, headache,

CV: heart failure, hypertension, edema , fluid retention

EENT : tinnitus, laryngeal edema, swelling of the lips and tongue, blurred vision, eye pain, night blindness, epistaxis, reversible hearing loss.

GI: abdominal pain or cramps, diarrhea, indigestion, nausea, abdominal distention, flatulence, taste disorder peptic ulceration, bleeding melena.

.Because NSAIDS impair the synthesis of renal prostaglandins, they can decrease renal blood flow and lead to reversible renal impairment, especially in patients with renal or heart failure or liver dysfunction, in elderly patients and in those taking diuretics. Monitor these patients closely.

Liver function test values may increase during therapy, Monitor transaminase especially ALT levels

Or impaired renal function.

periodically in patients undergoing long-term therapy. Make first transaminase measurement no later than 8 weeks after therapy begins.

Serious GI toxicity including peptic ulcer and bleeding can occur in patients taking NSAIDS despite lack of symptoms