Confidential and proprietary to Ventana Medical Systems, Inc. Do not copy. Do not distribute.

The future of pathologyDigital solutions transform tissue diagnostics in the United Kingdom

Confidential and proprietary to Ventana Medical Systems, Inc. Do not copy. Do not distribute.

Fast factsBirmingham Heartlands Hospital

• Hospital of Excellence– Largest hospital at Heart of England NHS Foundation Trust– Solid reputation for breast, skin, uropathology, lung and heart care

• Centralized AP lab for the Trust– Three hospitals (1,600+ beds) and one chest clinic – Serving a population of 1,000,000, caring for 750,000 annually– Lab volume: 175,000 slides per year

• 135,000 H&E • 33,000 IHC • 7,000 Special Stains

Confidential and proprietary to Ventana Medical Systems, Inc. Do not copy. Do not distribute.

Integrated Roche technologies Lab most recently implemented the Roche Digital Pathology portfolio

• Digital pathology– VENTANA iScan HT slide scanner– VENTANA Virtuoso image and workflow management software

• Staining automation– VENTANA BenchMark ULTRA staining system– VENTANA BenchMark XT system– VENTANA BenchMark Special Stains slide stainer

• Barcode tracking and workflow automation– VENTANA VANTAGE workflow solution

Confidential and proprietary to Ventana Medical Systems, Inc. Do not copy. Do not distribute.

Digital pathology transforms tissue diagnostics at Birmingham HospitalMany benefits for the pathology community

Improves collaboration with clinicians and education for junior pathologists while streamlining lab workflow

VIRTUAL CONSULTATION EDUCATIONIMAGE ANALYSIS

Confidential and proprietary to Ventana Medical Systems, Inc. Do not copy. Do not distribute.

Pathologists experience time savingsFuture potential: digital images offer access in seconds

“Before digital pathology, my staff would ask me 2-3 times per week to locate slides needed for an multidisciplinary team meeting, which involved a considerable amount of my time. Digital pathology now provides us with a robust mechanism for easy slide storage and retrieval.” — Dr. Simon Trotter, Histopathologist

“Once your workload is scanned in, then it will be available instantly — to report, to present at a tumor board meeting or to request a second opinion. What used to take days to get across to an expert will take seconds with digital pathology.”— Martin Collard, Technical Laboratory Lead

Confidential and proprietary to Ventana Medical Systems, Inc. Do not copy. Do not distribute.

More efficient tumor boards and second opinionsReduces time spent fetching cases

• Slides are more easily circulated to a greater number of consultants

• Multidisciplinary meetings are more effective and efficient

Slides are instantly available on consultants’ desktops

Confidential and proprietary to Ventana Medical Systems, Inc. Do not copy. Do not distribute.

Pathology education is now fully digitalPathologists and students no longer tethered to microscope

“One of the great advantages of digital pathology is its role in education. We have numerous conditions, tumors, and everything to diagnose under our microscope. We needed to find some way of having slides that our junior staffs can easily access to actually see firsthand what the tissue is, what the diagnosis is, and also to arrange interaction —which the digital platform will very easily do.”— Dr. Simon Trotter, Histopathologist

Aligns with junior staff expectations for a digital future…

Confidential and proprietary to Ventana Medical Systems, Inc. Do not copy. Do not distribute.

Digital measurements easier, more accurateResults in “the WOW factor” from colleagues

The software automatically notes measurements and saves annotations on slide images. These annotations equip pathologists to show resection margin clearance with ease, resulting in what

histopathologist Dr. Simon Trotter describes as “the wow factor” — positive reactions from colleagues and clinicians when viewing annotated digital slide images.

“ZERO diagnostic

discrepancies between glass and digital slides”

— Dr. Simon Trotter, Histopathologist

Confidential and proprietary to Ventana Medical Systems, Inc. Do not copy. Do not distribute.

Image and workflow management is robustSaves pathologists considerable time in reporting

WORKFLOW GAINS for pathologists and quality assurance department

www.roche.comwww.ventana.com© 2015 Ventana Medical Systems, Inc. VENTANA, BENCHMARK, VANTAGE, VENTANA ISCAN and VIRTUOSO are trademarks of Roche. All other trademarks are the property of their respective owners. 6021A-3 1215

Doing now what patients need next