direct arylation speaker: chien-an chen teacher: guey-sheng liou
TRANSCRIPT
Direct Arylation V.S. Traditional Cross-Coupling
Advantage of direct arylation:
1. Without metallic halides by-product
→good for enviorment
2. Reduce the synthetic operations →economical
Define of direct arylation:Through cleavage of C-H bond
Direct Arylation on LBG polymer• Disadvantage:The critical factor of direct arylation polymerization is regioselectivity. Example:
Solution method: Use protecting group, methyl, to protect 3-position of thiophene. Example:
The two hydrogen atoms are also reactive
Cross-linked polymer
Conclusion
• Until very recently, the majority of catalytic direct arylations have been accomplished with palladium, rhodium, or ruthenium catalysts. However, less-expensive copper, iron, and nickel compounds have been shown.
• The use of atom-economical terminal oxidants and achieving regioselectivity in intermolecular arylations remain significant challenges.