directory - grintechgrintech is one of the leading manufacturers of gradient index (grin)...

1

Directory

The Company 2

GRIN Rod Lenses – Numerical Aperture 0.5 3

GRIN Rod Lenses with intermediate Numerical Aperture = 0.28 – 0.33 4

GRIN Rod Lenses – Numerical Aperture 0.2 5

GRIN Rod Lenses – Numerical Aperture 0.2 – for high performance collimation 6

GRIN Cylindrical Lenses 7

GRIN Objective Lenses for Endoscopy 8

GRIN Endoscopic Rod Lens Systems 9

Partnership 10

GRIN Needle Endomicroscopes 11

High NA Endomicroscopic Imaging Objective for Fluorescence Microscopy 12

High NA Endomicroscopic Imaging Objective for 2-Photon Microscopy 13

High NA Endomicroscopic Imaging Objective as Achromatic version 14

Small Size Laser-optic Line Generator 15

Customized GRIN Lens Assemblies 16

In Vivo Medical Confocal Imaging and Optical Coherence Tomography 17

Introduction to Gradient Index (GRIN) Lenses 18

Introduction to Gradient Index Imaging Optics 19

Contact 20

2

The Company

GRINTECH is one of the leading manufacturers of gradient index (GRIN) micro-optic lenses and lens systems

based on more than 20-years of experience.

GRINTECH delivers medical imaging and biophotonic technology, optical metrology and sensor technology

to growing markets.

GRIN-lenses are miniaturized lenses having extraordinary good optical performance and flat optical surfaces.

The optical power of GRIN-lenses is achieved by a refractive index (GRadient INdex) profile fabricated by a

non-toxic silver and lithium ion exchange process in glass. Our unique rod and cylindrical micro lenses have

typical dimensions from 200 µm to 2 mm.

With diffraction-limited numerical apertures up to 0.45. The flat optical surfaces enable an easy assembly to

micro-optical lens systems tailored to your specific requirements.

GRINTECH GmbH was founded in 1999 as a spin-off of the Fraunhofer Institute for Applied Optics and

Precision Engineering in Jena, Germany.

We at GRINTECH support the GRIN technology with our long-standing technical expertise and

reliable customer service.

red dot: headquarters GRINTECH GmbH source: JENA Wirtschaft / Jürgen Scheere

3

GRIN Rod Lenses – Numerical Aperture 0.5

� Working distance, design wavelength and lens length deviating from these standards can also be produced

� 8° angled facet / other diameters (0.60 and 0.85 mm) are available on request

� ZEMAX files can be DOWNLOADed from our website

Pitch P Working

distance

s (mm)

Numerical

Aperture

NA

Lens length

zl (mm) Focal

length

f (mm)

Gradient

constant

g (mm-1)

Refractive index

at the center of

the profile no

Wavelength

λ (nm)

Product code

Diameter d: 0.35 mm

0.25 0 0.56 0.77 0.30 2.032 1.629 670 GT-LFRL-035-025-50-CC (670)

0.23 0.04 0.56 0.70 0.31 2.032 1.629 670 GT-LFRL-035-023-50-CC (670)

0.25 0 0.55 0.78 0.31 2.019 1.624 810 GT-LFRL-035-025-50-CC (810)

0.23 0.04 0.55 0.71 0.31 2.019 1.624 810 GT-LFRL-035-023-50-CC (810)

0.25 0 0.54 0.78 0.31 2.004 1.616 1550 GT-LFRL-035-025-50-CC (1550)

0.23 0.04 0.54 0.72 0.31 2.004 1.616 1550 GT-LFRL-035-023-50-CC (1550)

Diameter d: 0.5 mm

0.25 0 0.54 1.15 0.45 1.369 1.629 670 GT-LFRL-050-025-50-CC (670)

0.23 0.06 0.54 1.05 0.45 1.369 1.629 670 GT-LFRL-050-023-50-CC (670)

0.25 0 0.53 1.15 0.45 1.361 1.624 810 GT-LFRL-050-025-50-CC (810)

0.23 0.06 0.53 1.05 0.46 1.361 1.624 810 GT-LFRL-050-023-50-CC (810)

0.25 0 0.53 1.16 0.46 1.349 1.616 1550 GT-LFRL-050-025-50-CC (1550)

0.23 0.06 0.53 1.06 0.46 1.349 1.616 1550 GT-LFRL-050-023-50-CC (1550)

Diameter d: 1.0 mm

0.25 0 0.55 2.25 0.88 0.697 1.629 670 GT-LFRL-100-025-50-CC (670)

0.23 0.12 0.55 2.05 0.89 0.697 1.629 670 GT-LFRL-100-023-50-CC (670)

0.25 0 0.54 2.27 0.89 0.693 1.624 810 GT-LFRL-100-025-50-CC (810)

0.23 0.12 0.54 2.06 0.90 0.693 1.624 810 GT-LFRL-100-023-50-CC (810)

0.25 0 0.53 2.29 0.90 0.687 1.616 1550 GT-LFRL-100-025-50-CC (1550)

0.23 0.12 0.53 2.08 0.91 0.687 1.616 1550 GT-LFRL-100-023-50-CC (1550)

Diameter d: 1.8 mm

0.25 0 0.52 4.24 1.66 0.370 1.629 670 GT-LFRL-180-025-50-CC (670)

0.23 0.23 0.52 3.85 1.68 0.370 1.629 670 GT-LFRL-180-023-50-CC (670)

0.25 0 0.52 4.27 1.67 0.368 1.624 810 GT-LFRL-180-025-50-CC (810)

0.23 0.23 0.52 3.88 1.69 0.368 1.624 810 GT-LFRL-180-023-50-CC (810)

0.25 0 0.51 4.30 1.70 0.365 1.616 1550 GT-LFRL-180-025-50-CC (1550)

0.23 0.23 0.51 3.92 1.71 0.365 1.616 1550 GT-LFRL-180-023-50-CC (1550)

Diameter d: 2.0 mm

0.25 0 0.51 4.85 1.89 0.324 1.629 670 GT-LFRL-200-025-50-CC (670)

0.23 0.25 0.51 4.42 1.91 0.324 1.629 670 GT-LFRL-200-023-50-CC (670)

0.25 0 0.51 4.88 1.91 0.322 1.624 810 GT-LFRL-200-025-50-CC (810)

0.23 0.25 0.51 4.45 1.93 0.322 1.624 810 GT-LFRL-200-023-50-CC (810)

0.25 0 0.50 4.92 1.94 0.319 1.616 1550 GT-LFRL-200-025-50-CC (1550)

0.23 0.25 0.50 4.50 1.96 0.319 1.616 1550 GT-LFRL-200-023-50-CC (1550)

GRIN rod lenses are offered with antireflection coatings (R < 0.5 % for the design

wavelength and incidence angles of 0 ... 30° corresponding to measurements on a

reference substrate)

Coating Code: NC: no coating (reflection loss approx. 12 %)

C1: λ = 450 … 690 nm

C2: λ = 800 … 960 nm

C5: λ = 1310 … 1550 nm

Variations due to modifications of the production process are possible.

It is the user´s responsibility to determine suitability for the user´s purpose.

Tolerances:

lens length zl: ± 5% due to variations of the gradient constant

working distance s: ± 0.02 mm

diameter d: + 0 / -0.01 mm

Please ask for tighter diameter tolerances

Surface quality:

5 / 3 x 0.025; L 3 x 0.005; E 0 (defined by DIN ISO 10110-7:2000-02).

The surface quality is defined within 90 % of the lens diameter. Outside of this

area defects are allowed.

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Gradient index lenses for fiber coupling and beam shaping of laser diodes

GT-LFRL-100-025-50-CC (670)

GRINTECH

Laser Focusing Rod Lens

Diameter: 1.0 mm

Pitch: 0.25

NA: 0.5

Coating Code

Design wavelength

Order example:

Please note our partnership with Inscopix as our exclusive distributor for the field of non-confocal, single photon epi-fluorescence imaging for neuroscience applications

in non-humans (see page 10).

4

New: GRIN Rod Lenses with intermediate NA = 0.28 – 0.33 Gradient index lenses for fiber coupling, beam shaping of laser diodes and imaging applications


� 8° angled facet are available on request


Pitch P Working

distance

s (mm)

Numerical

Aperture

NA

Lens length

zl (mm) Focal

length

f (mm)

Gradient

constant

g (mm-1)

Refractive index

at the center of

the profile no

Wavelength

λ (nm)

Product code

Diameter d: 0.5 mm

0.25 0 0.28 2.27 0.89 0.694 1.613 670 GT-LFRL-050-025-28-CC (670)

0.23 0.10 0.28 2.10 0.90 0.694 1.613 670 GT-LFRL-050-023-28-CC (670)

0.25 0 0.28 2.28 0.90 0.689 1.608 810 GT-LFRL-050-025-28-CC (810)

0.23 0.10 0.28 2.12 0.91 0.689 1.608 810 GT-LFRL-050-023-28-CC (810)

0.25 0 0.27 2.31 0.92 0.681 1.600 1310-1550 GT-LFRL-050-025-28-CC (1550)

0.23 0.10 0.27 2.15 0.92 0.681 1.600 1310-1550 GT-LFRL-050-023-28-CC (1550)

Diameter d: 1.0 mm

0.25 0 0.33 3.67 1.47 0.428 1.585 670 GT-LFRL-100-025-33-CC (670)

0.23 0.18 0.33 3.38 1.49 0.428 1.585 670 GT-LFRL-100-023-33-CC (670)

0.25 0 0.33 3.70 1.49 0.425 1.581 810 GT-LFRL-100-025-33-CC (810)

0.23 0.18 0.33 3.41 1.50 0.425 1.581 810 GT-LFRL-100-023-33-CC (810)

0.25 0 0.33 3.74 1.51 0.420 1.574 1310-1550 GT-LFRL-100-025-33-CC (1550)

0.23 0.18 0.32 3.45 1.52 0.420 1.574 1310-1550 GT-LFRL-100-023-33-CC (1550)

Diameter d: 1.8 mm

0.25 0 0.32 7.11 2.78 0.221 1.629 670 GT-LFRL-180-025-32-CC (670)

0.23 0.34 0.32 6.55 2.81 0.221 1.629 670 GT-LFRL-180-023-32-CC (670)

0.25 0 0.32 7.16 2.81 0.219 1.624 810 GT-LFRL-180-025-32-CC (810)

0.23 0.34 0.32 6.60 2.83 0.219 1.624 810 GT-LFRL-180-023-32-CC (810)

0.25 0 0.32 7.24 2.86 0.217 1.616 1310-1550 GT-LFRL-180-025-32-CC (1550)

0.23 0.34 0.32 6.68 2.88 0.217 1.616 1310-1550 GT-LFRL-180-023-32-CC (1550)

Diameter d: 2.0 mm

0.25 0 0.30 7.99 3.24 0.197 1.570 670 GT-LFRL-200-025-30-CC (670)

0.23 0.40 0.30 7.36 3.27 0.197 1.570 670 GT-LFRL-200-023-30-CC (670)

0.25 0 0.30 8.05 3.27 0.195 1.566 810 GT-LFRL-200-025-30-CC (810)

0.23 0.40 0.30 7.42 3.30 0.195 1.566 810 GT-LFRL-200-023-30-CC (810)

0.25 0 0.30 8.14 3.32 0.193 1.559 1310-1550 GT-LFRL-200-025-30-CC (1550)

0.23 0.40 0.30 7.52 3.35 0.193 1.559 1310-1550 GT-LFRL-200-023-30-CC (1550)





C1: λ = 450 … 690 nm

C2: λ = 800 … 960 nm

C5: λ = 1310 … 1550 nm



Tolerances:





Surface quality:




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GT-LFRL-100-025-33-CC (670)

GRINTECH


Diameter: 1.0 mm

Pitch: 0.25

NA: 0.33

Coating Code

Design wavelength

Order example:

5

GRIN Rod Lenses – Numerical Aperture 0.2

Gradient index lenses for fiber coupling and beam shaping of laser diodes

� Working distance, design wavelength and lens length deviating from these standards on request

� 8° angled facet is available on request


Pitch P Working

distance

s (mm)

Numerical

Aperture

NA

Lens length

zl (mm)

Focal

length

f (mm)

Gradient

constant

g (mm-1)

Refractive index

at the center of

the profile no

Wavelength

λ (nm)

Product code

Diameter d: 0.35 mm

0.25 0 0.20 2.14 0.89 0.734 1.524 670 GT-LFRL-035-025-20-CC (670)

0.24 0.05 0.20 2.06 0.89 0.734 1.524 670 GT-LFRL-035-024-20-CC (670)

0.25 0 0.20 2.15 0.90 0.730 1.521 810 GT-LFRL-035-025-20-CC (810)

0.24 0.05 0.20 2.07 0.90 0.730 1.521 810 GT-LFRL-035-024-20-CC (810)

0.25 0 0.20 2.16 0.91 0.727 1.515 1310-1550 GT-LFRL-035-025-20-CC (1550)

0.24 0.05 0.20 2.08 0.91 0.727 1.515 1310-1550 GT-LFRL-035-024-20-CC (1550)

Diameter d: 0.5 mm

0.25 0 0.20 3.05 1.28 0.515 1.524 670 GT-LFRL-050-025-20-CC (670)

0.24 0.08 0.20 2.93 1.28 0.515 1.524 670 GT-LFRL-050-024-20-CC (670)

0.25 0 0.20 3.06 1.28 0.513 1.521 810 GT-LFRL-050-025-20-CC (810)

0.24 0.08 0.20 2.94 1.28 0.513 1.521 810 GT-LFRL-050-024-20-CC (810)

0.25 0 0.20 3.07 1.29 0.511 1.515 1310-1550 GT-LFRL-050-025-20-CC (1550)

0.24 0.08 0.20 2.95 1.29 0.511 1.515 1310-1550 GT-LFRL-050-024-20-CC (1550)

Diameter d: 1.0 mm

0.25 0 0.20 6.12 2.56 0.257 1.524 670 GT-LFRL-100-025-20-CC (670)

0.24 0.16 0.20 5.87 2.56 0.257 1.524 670 GT-LFRL-100-024-20-CC (670)

0.25 0 0.20 6.13 2.57 0.256 1.521 810 GT-LFRL-100-025-20-CC (810)

0.24 0.16 0.20 5.89 2.57 0.256 1.521 810 GT-LFRL-100-024-20-CC (810)

0.25 0 0.20 6.16 2.59 0.255 1.515 1310-1550 GT-LFRL-100-025-20-CC (1550)

0.24 0.16 0.20 5.92 2.59 0.255 1.515 1310-1550 GT-LFRL-100-024-20-CC (1550)

Diameter d: 1.8 mm

0.25 0 0.20 11.15 4.66 0.141 1.524 670 GT-LFRL-180-025-20-CC (670)

0.24 0.28 0.20 10.72 4.66 0.141 1.524 670 GT-LFRL-180-024-20-CC (670)

0.25 0 0.20 11.17 4.68 0.140 1.521 810 GT-LFRL-180-025-20-CC (810)

0.24 0.28 0.20 10.74 4.68 0.140 1.521 810 GT-LFRL-180-024-20-CC (810)

0.25 0 0.20 11.22 4.72 0.139 1.515 1310-1550 GT-LFRL-180-025-20-CC (1550)

0.24 0.28 0.20 10.79 4.72 0.139 1.515 1310-1550 GT-LFRL-180-024-20-CC (1550)


wavelength and incidence angles of 0° ... 30° corresponding to measurements on a



C1: λ = 450 … 690 nm

C2: λ = 800 … 960 nm

C5: λ = 1310 … 1550 nm



Tolerances:





Surface quality:




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GT-LFRL-100-025-20-CC (670)

GRINTECH


Diameter: 1.0 mm

Pitch: 0.25

NA: 0.2

Coating Code

Design wavelength

Order example:

6

NEW: GRIN Rod Lenses – Numerical Aperture 0.2 – for high-performance collimation

Diameter 1.80 mm:

with optimized gradient index profile for compensation of higher-order spherical aberrations and better beam quality

� Working distance, design wavelength and lens length deviating from these standards on request

� 8° angled facet is available on request

Pitch P Working

distance

s (mm)

Numerical

Aperture

NA

Lens length

zl (mm)

Focal

length

f (mm)

Gradient

constant

g (mm-1)

Refractive index

at the center of

the profile no

Wavelength

λ (nm)

Product code

Diameter d: 1.8 mm

0.25 0 0.20 11.15 4.66 0.141 1.524 670 GT-LFRL-180-025-20-CC (670)

0.24 0.28 0.20 10.72 4.66 0.141 1.524 670 GT-LFRL-180-024-20-CC (670)

0.25 0 0.20 11.17 4.68 0.140 1.521 810 GT-LFRL-180-025-20-CC (810)

0.24 0.28 0.20 10.74 4.68 0.140 1.521 810 GT-LFRL-180-024-20-CC (810)

0.25 0 0.20 11.22 4.72 0.139 1.515 1310-1550 GT-LFRL-180-025-20-CC (1550)

0.24 0.28 0.20 10.79 4.72 0.139 1.515 1310-1550 GT-LFRL-180-024-20-CC (1550)

GT-CFRL-180-xxx-20-CC (xxxx) / all dimensions equivalent to standard GT-LFRL-180-xxx-20-CC (xxxx)

optimized GT-CFRL-180-xxx-20-CC (xxxx)

- Wavefront RMS @ 635 nm < 0.07

- diffraction limited properties

- higher order spherical aberrations are corrected

- for high-performance applications

(e.g. collimators with M² < 1.1)

measured wavefront error: 0.055ʎ RMS

for comparison:

standard GT-LFRL-180-xxx-20-CC (xxxx)

- suitable for most common telecom applications

- Wavefront RMS @ 635 nm < 0.2

- residual aberration: higher order spherical aberrations

measured wavefront error: 0.153ʎ RMS


wavelength and incidence angles of 0° ... 30° corresponding to measurements on a



C1: λ = 450 … 690 nm

C2: λ = 800…960 nm

C5: λ = 1310 … 1550 nm



Tolerances:





Surface quality:




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7

GRIN Cylindrical Lenses

� Gradient index lenses for the fast axis collimation of high power laser diode bars, high brightness diodes and other beam shaping

purposes

� Plane surfaces


� different lens width available upon request


Pitch P Working

distance

s (mm)

Numerical

Aperture

NA

Lens length

zl (mm)

Focal

length

f (mm)

Gradient

constant

g (mm-1)

Refractive index

at the center of

the profile no

Width b

(mm)

Wavelength

λ (nm)

Product code

Thickness d : 1.0 mm

0.24 0.08 0.5 2.34 0.97 0.634 1.624 14 810 GT-LFCL-100-024-50-CC (810)

0.24 0.08 0.5 2.35 0.98 0.632 1.621 14 940 GT-LFCL-100-024-50-CC (940)

GRIN cylindrical lenses are offered with antireflection coatings (R < 0.5 % for the

design wavelength and incidence angles of 0 ... 30° corresponding to measurements

on a reference substrate)


C2: λ = 800 … 960 nm



Tolerances:


thickness d: ± 0.02 mm


Surface quality:


The surface quality is defined within 90 % of the thickness and within

b – 1 mm of the width. Outside of this area defects are allowed.

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b

d

s

zl

GT-LFCL-100-024-50-CC (810)

GRINTECH

Laser Focusing Cylindrical Lens

Thickness: 1.0 mm

Pitch: 0.24

N.A.: 0.5

Coating Code

Design wavelength

Order example:

8

GRIN Objective Lenses for Endoscopy

� Gradient index lenses for endoscopic imaging optics

� Non-toxic silver-based glass material, view angle ϑ = ± 30°

� Plane surfaces, low chromatic aberration

� Combination with prisms and beam splitter cubes on request

� Working distance and lens length deviating from these standards can also be produced


Diameter

d (mm)

Working distance

l (mm)

Lens length1

zl (mm)

Parax. Magnification

M = yo/yi

Refractive index at the

center of the profile no

Product code

2.0 Infinity 4.79 -- 1.635 GT-IFRL-200-inf-50-CC

2.0 20 5.06 -10.78 1.635 GT-IFRL-200-020-50-CC

2.0 10 5.33 -5.46 1.635 GT-IFRL-200-010-50-CC

2.0 5 5.84 -2.86 1.635 GT-IFRL-200-005-50-CC


1.8 20 4.40 -12.29 1.635 GT-IFRL-180-020-50-CC

1.8 10 4.61 -6.21 1.635 GT-IFRL-180-010-50-CC

1.8 5 5.01 -3.22 1.635 GT-IFRL-180-005-50-CC


1.0 20 2.29 -23.1 1.635 GT-IFRL-100-020-50-CC

1.0 10 2.35 -11.58 1.635 GT-IFRL-100-010-50-CC

1.0 5 2.46 -5.86 1.635 GT-IFRL-100-005-50-CC


0.85 10 2.02 -13.34 1.635 GT-IFRL-085-010-50-CC

0.85 5 2.11 -6.73 1.635 GT-IFRL-085-005-50-CC


0.6 10 1.36 -19.48 1.635 GT-IFRL-060-010-50-CC

0.6 5 1.40 -9.78 1.635 GT-IFRL-060-005-50-CC


0.5 10 1.16 -22.71 1.635 GT-IFRL-050-010-50-CC

0.5 5 1.19 -11.39 1.635 GT-IFRL-050-005-50-CC

0.35 5 0.79 -16.9 1.635 GT-IFRL-035-005-50-CC

0.25 5 0.56 -23.63 1.635 GT-IFRL-025-005-50-CC 1 Design Wavelength 570 nm

GRINTECH Objective lenses are available with AR coatings (R < 0.5 % for the design




C1: AR coating for VIS on both sides



Tolerances:




Surface quality:


The surface quality is defined within 90 % of the lens diameter. Outside of

this area defects are allowed.

Note: GRINTECH objective lenses can be combined with GRIN relay

lenses to complete endoscopic imaging systems by gluing the optical

surfaces directly together. Prisms to change the direction of view

can also be glued directly on the front surface of the objective lens.

We are happy to advise you.

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� Aperture and field stops (black chromium coating ring on lens

surface generated by photolithography) on request

� Certification: Biological safety – toxicology (EN ISO 10993-1)

ϑ

yO

yi

l zl

ddA

GT-IFRL-100-010-50-CC

GRINTECH

Imaging Focusing Rod Lens

Diameter: 1.0 mm

Working distance: 10 mm

NA: 0.5

Coating Code

Order example:

Please note our partnership with Inscopix as our exclusive distributor for the field of non-confocal, single photon epi-fluorescence imaging for neuroscience applications

in non-humans (see page 10).

9

GRIN Endoscopic Rod Lens Systems

GRIN endoscopic systems, which combine a GRIN objective lens, a GRIN relay lens and a GRIN eyepiece. Combining the system with a

prism enables the change of the direction of view (see Fig. 2). Standard diameters are 0.5, 1.0 und 2.0 mm. We offer the systems in two

different principle design options:

A. The objective lens creates a reduced intermediate image at the exit surface of the objective lens, which will be imaged by the relay lens

1:1 (if the lens length of the relay lens is a multiple of the period) or - 1:1 (if the lens length of the relay lens is an odd multiple of the

half period) to the exit surface of the relay lens.

B. The objective lens creates a reduced intermediate image at the exit surface of the objective lens, which will be imaged by the relay lens

(including the eyepiece in form of a ¼ pitch-lens (e.g. 0.75 pitch, 1.25 pitch, 1.75 pitch etc.) at infinity. Such a lens system is a com-

plete endoscopic imaging system. It allows the direct observation with the human eye or the use of a conventional camera system (in-

cluding camera lens).

Schematic view of the two designs:

Fig. 1: Examples of designs for GRINTECH endoscopic systems. The pitch length can be

increased by a whole number of the half pitch length in dependence on the requested

endoscope length. Details are shown in table 1.

Table 1: Example configurations of endoscopic systems

Design [Ø - pitch] Diameter [mm] Image orientation System length [mm] Comment

0.5 - 0.75 0.5 like Design B approx. 23.9 with eyepiece

0.5 - 1.0 0.5 like Design A approx. 31.5 without eyepiece

0.5 - 1.25 0.5 inverted to Design B approx. 39.1 with eyepiece

0.5 - 1.5 0.5 inverted to Design A approx. 46.6 without eyepiece








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We are happy to advise you. Please contact us.

Fig. 2: Changing the direction of view of a

GRIN lens by a 90° prism

object objective lens relay lens

CCD

eye

0.5 Pitch

1.0 Pitch

0.75 Pitch

- intermediate image

30°

object

objective

90° prism

1

0

Brain Imaging – one of the most enabling applications of GRINTECH micro-optics

Endomicroscopy using GRINTECH lenses and assemblies allows an in-vivo imaging access to

deep tissue regions in the brain, especially in non-humans. It helps to understand disease

formation and progression on a cellular level of the tissue.

To support our customers even better by providing appropriate biological techniques and

protocols, GRINTECH has created a partnership with Inscopix Inc. in Palo Alto, California,

one of the leading technology providers in neuroscience microscopic imaging.

Beginning on December 1st, 2015 Inscopix will distribute exclusively our products in the field

of non-confocal, single photon epi-fluorescence imaging for neuroscience applications in

non-humans.

www.inscopix.com

11

GRIN Needle Endomicroscopes

GRIN Needle Endomicroscopes are used for deep tissue imaging. They relay the micron-scale resolved image of the tissue over a longer length

to a plane outside of the tissue at the other end of the needlescope. Most frequently they are used with multi-photon fluorescence imaging

(Design Wavelength 860 nm) or with epi-fluorescence imaging (Design Wavelength 520 nm).

The Endomicroscopes are fabricated as GRIN-singlets with NA = 0.50 on both sides or as GRIN-doublets with an object NA of 0.5 and an

image NA of 0.19. Working distances on object side are specified in water or tissue, on image side in air. The doublets are offered in different

lengths resulting from adding 0.5 GRIN-pitches (periods) to the GRIN relay lens (NA = 0.19).

Product Code Length

(mm)

Working distance

in water (µm)

object side

Working distance

in air (µm)

image side

Design

Wavelength

(nm)

NA

object side /

image side

Magnification

Image / Object

Singlet /

Doublet

Diameter d: 0.5 mm

NEM-050-06-00-520-S 2.20 60 0 520 0.50 / 0.50 1:1 S

NEM-050-25-10-860-S 1.87 250 100 860 0.50 / 0.50 1:1 S

NEM-050-06-08-520-DS 3.98 60 80 520 0.50 / 0.19 2.8 : 1 D

NEM-050-06-08-520-DM 10.08 60 80 520 0.50 / 0.19 2.8 : 1 D

NEM-050-06-08-520-DL 16.19 60 80 520 0.50 / 0.19 2.8 : 1 D

NEM-050-25-10-860-DS 3.79 250 100 860 0.50 / 0.19 2.6 : 1 D

NEM-050-25-10-860-DM 9.89 250 100 860 0.50 / 0.19 2.6 : 1 D

NEM-050-25-10-860-DL 16.00 250 100 860 0.50 / 0.19 2.6 : 1 D

Diameter d: 1.0 mm

NEM-100-06-00-520-S 4.67 60 0 520 0.50 / 0.50 1:1 S

NEM-100-06-08-520-S 4.54 60 80 520 0.50 / 0.50 1:1 S

NEM-100-25-10-860-S 4.38 250 100 860 0.50 / 0.50 1:1 S

NEM-100-06-08-520-DS 8.28 60 80 520 0.50 / 0.19 2.7 : 1 D

NEM-100-06-08-520-DL 20.50 60 80 520 0.50 / 0.19 2.7 : 1 D

NEM-100-25-10-860-DS 8.10 250 100 860 0.50 / 0.19 2.6 : 1 D

NEM-100-25-10-860-DL 20.33 250 100 860 0.50 / 0.19 2.6 : 1 D

Notes:

� Diameters are sole GRIN-optics diameters

� Optionally the Endomicroscopes can be delivered in medical-grade stainless steel tubes (1.4301), with outer diameters of 0.70 mm for 0.5 mm

optics and 1.2 mm for 1.0 mm optics. The tubes are mounted flush on the object side (tissue, high NA). On the image side, the optics sticks out

of the tube by 200 – 500 µm. Please add –ST to the product code if desired.

� The lengths can have a tolerance of +/- 5 %.

� The lenses are non-coated. For customized projects, the lenses can be AR-coated.

� A side-viewing scope using microprisms may be also possible on a customized basis.

� Diameter 0.35 mm on request.

� Other working distances on request

� Please ask for combination with imaging fiber bundles (Fujikura) as customized solution.

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NEM-100-06-08-520-DS

Needle Endomicroscope

Diameter: 1.0 mm

Working distance in water [µm] – objective side

Working distance in air [µm] – image side

Design Wavelength [nm]

Singlet or Doublet

Relay pitch: Short (0.25 pitch) – Long (0.75 pitch)

NEM-050-06-08-520-DS

Needle Endomicroscope

Diameter: 0.5 mm

Working distance in water [µm] – objective side

Working distance in air [µm] – image side

Design Wavelength [nm]

Singlet or Doublet

Relay pitch: Short (0.25 pitch) – Medium (0.75 pitch) – Long (1.25 pitch)

Order example:

Please note our partnership with Inscopix as our exclusive distributor

for the field of non-confocal, single photon epi-fluorescence imaging

for neuroscience applications in non-humans (see page 10).

12

High-NA Endomicroscopic Imaging Objective for Fluorescence Microscopy

GRINTECH’s high-NA Endomicroscopic Imaging Objectives cascade the optical power of a plano-convex lens and a GRIN lens with aberration

compensation to achieve an object NA of 0.8.

Applications: In vivo endomicroscopy, fluorescence microscopy, tissue imaging, flexible fluorescence microscopy, NA conversion

Product Code: GT-MO-080-018-488


Features: � Object NA = 0.80

� Object working distance 80 µm (water)

� Image NA = 0.18

� Magnification 4.65 x

� Recommended Excitation 488 nm

� Mounted in stainless steel holder



� Image NA = 0.415


� Recommended Excitation 488 nm


Object NA = 0.8

Object wd = 80 µm in water

Image wd = 200 µm in air

Image NA = 0.18

1.4 mm

7.00 mm

7.65 mm (+/-0.17mm)



Object NA = 0.8

Image NA = 0.415

1.4 mm

3.30 mm

4.10 mm (+/-0.35 mm)

Diffraction limited NA versus Field


0 10 20 30 40 500.0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

0.8

N.A

. diffr

actio

n lim

ited

radial object field height [µm]

(from optical design simulation according to Marechal

criterion @ 488 nm, wavefront RMS ≤ 0.07 λ)

0 10 20 30 40 500.0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

0.8

N.A

. d

iffr

action

lim

ite

d




Chromatic Aberration in Object Space Chromatic Aberration in Object Space

460 480 500 520 540 56070

75

80

85

90

95

work

ing

dis

tan

ce

in

wa

ter

[µm

]

λ [nm]

460 480 500 520 540 56070

75

80

85

90

95

work

ing d

ista

nce

in w

ate

r [µ

m]

λ [nm]

Rev

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Variations due to modifications of the production process are possible. It is the user´s responsibility to determine suitability for the user´s purpose.

Pat. US 7,511,891

13

High-NA Endomicroscopic Imaging Objective for 2-Photon Microscopy

GRINTECH’s high-NA Endomicroscopic Imaging Objectives cascade the optical power of a plano-convex lens and a GRIN lens with aberration

compensation to achieve an object NA of 0.8.

Applications: In vivo endomicroscopy, 2-photon microscopy, deep brain and tissue imaging, flexible fluorescence microscopy,

NA conversion





� Image NA = 0.18


� Recommended Excitation 800 – 900 nm




� Image NA = 0.415


� Recommended Excitation 800 – 900 nm



Object NA = 0.8


Image NA = 0.18

1.4 mm

7.00 mm

7.50 mm (+/-0.17 mm)



Object NA = 0.8

ImageNA = 0.415

1.4 mm

3.30 mm

4.00 mm (+/-0.35 mm)



0 10 20 30 40 500,0

0,1

0,2

0,3

0,4

0,5

0,6

0,7

0,8

N.A

. diffr

action lim

ite

d




0 10 20 30 40 500.0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

0.8

N.A

. d

iffr

actio

n lim

ited




Chromatic Aberration in Object Space Chromatic Aberration in Object Space

700 750 800 850 900 950 1000

195

200

205

wo

rkin

g d

ista

nce

in

wa

ter

[µm

]

λ [nm]

700 750 800 850 900 950 1000

195

200

205

wo

rkin

g d

ista

nce

in w

ate

r [µ

m]

λ [nm]

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Pat. US 7,511,891

14

High-NA Endomicroscopic Imaging Objective now available as achromatic version

GRINTECH’s high-NA Endomicroscopic Imaging Objectives with object Numerical Apertures of 0.8 are now offered in an achromate version

for applications where a wavelength depending focal shift between the excitation and detection is a problem and needs to be corrected.

Applications:

In vivo endomicroscopy, fluorescence microscopy, tissue imaging, flexible fluorescence

microscopy, NA conversion

Applications:

In vivo endomicroscopy, 2-photon

endomicroscopy, deep brain and tissue imaging,

flexible fluorescence microscopy

New Product Code:

GT-MO-080-018-AC488-550

New Product Code:

GT-MO-080-0415-AC488-550

New Product Code:

GT-MO-080-018-AC900-450

Features � Object NA = 0.80

� Object working distance

80 µm (water)

� Image NA = 0.18


� Recommended Excitation

488 nm

� Mounted in stainless steel

holder

� Color correction for 488 and

550 nm



80 µm (water)

� Image NA = 0.50



488 nm


holder

� Color correction for 488

and 550 nm



200 µm (water)

� Image NA = 0.175



800 - 900 nm


holder

� Color correction for 900 and

450 nm

Chromatic Aberration in Object Space Chromatic Aberration in Object Space Chromatic Aberration in Object Space

480 500 520 540 56079

80

81

82

83

84

85

86

87

88

MO-080-018-AC488-550

(with chromatic correction)

MO-080-0415-488

(no chromatic correction)

work

ing

dis

tan

ce

in

wa

ter

[µm

]

λ [nm]

480 500 520 540 560

80

85

90

MO-080-0415-AC488-550


MO-080-0415-488


wo

rkin

g d

ista

nce in

wa

ter

[µm

]

λ [nm]

400 500 600 700 800 900165

170

175

180

185

190

195

200

205

210

MO-080-018-AC450-900


MO-080-018-810


work

ing d

ista

nce in w

ate

r [µ

m]

λ [nm]


Pat. US 7,511,891 Revision 12/2015

15

y

x

I

I

y

x

Small Size Laser-optic Line Generator

GRINTECH’s Gradient-Index Micro-Optic Components with plane optical

surfaces generate a homogeneous laser line from a Gaussian beam of a

single-mode laser diode. The extraordinary small module size of

∅ 6.43 mm x 10.5 mm and a weight of only 0.9 g are combined with a

line uniformity of approx. ± 8% and a diffraction-limited focus size.

Applications: 3D contour mapping

Optical alignment

Machine vision

Biomedical

Standard Options:

� Line divergence (Fan angle): ± 10°, ± 15°, ± 20° (see ordering

information below)

� Line focus position can be specified between 80 mm and infinity

(collimation) when ordering. Please see remarks below for focus size

and depth of focus.

� Red laser diode: QDLaser – QLF063A-AA, λ = 660 nm, PLD = 50 mW,

TO-18 (∅ 5.6 mm) package (driver on request)

� Input laser beam specification for laser diodes TO-18:

Slow axis divergence: 9 deg. (+1.5 / - 0.5 deg.) @ FWHM

Mechanical Specifications:

� Weight: 0.9 g

� Dimensions version 1: ∅ 6.43 mm x 10.5 mm

� Dimensions version 2: ∅ 8.00 mm x 10.5 mm

� Package material: anodised aluminium

Environmental Specifications:

� Operating temperature: 0 … 50°C

� Storage temperature: -20°C … +70°C

� Resistance to vibrations: 2 g / 20 ... 500 Hz (acc. IEC68-2-6)

� Resistance to mechanical shock: 15 g / 6 ms (acc. IEC68-2-29)

� Laser safety class: depending on application and additional optics up to

class 3B

Dimensions Version 1:

Optical Specifications:

� Fan divergence angles : ± 10°, ± 15°, ± 20°

� Focus distance: 80 mm – infinity, Gaussian shape

� Line width in focus: FWHM/Distance = 0.60 µm/mm,

Example: approx. 120 µm line width (FWHM) in 200 mm distance

� Far field divergence depending on line widths, approx. according to

Gaussian beam laws

� Squint angle: ≤ 2°

� Transmission efficiency: Pout / PLD = 90 – 95%

-10 -5 0 5 100,0

0,2

0,4

0,6

0,8

1,0

Example:

Line profile +/- 10° Module

Divergence angle in °

Rela

tive

Inte

nsi

ty

Example: Line width: 75 µm FWHMin focus distance 123 mm

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LASER RADIATION

AVOID EXPOSURE TO THE BEAM

CLASS 3B LASER PRODUCT

Variations due to modifications

of the production process are

possible. It is the user´s

responsibility to determine

suitability for the user´s

purpose.

GT-LLGM-643-DA-FD

GRINTECH

Laser Line Generator Modul

Diameter: 6.43 mm

Divergence angle: 10 for ±10°

15 for ±15°

20 for ±20°

Focus distance in mm

(between 80 mm and infinity)

Order example:

16

Customized GRIN Lens Assemblies

GRIN Fiber Pigtails GRIN Arrays

Applications: fiber optical sensors, biophotonic probes, optical

switches, fiber coupling

� Fiber Pigtails using Gradient Index Rod Lenses

� Focussing, collimating and imaging GRIN lenses

� Use of special fibers on request

� AR and beam splitting coatings on request

� 8° angled facet of fiber and optics possible

Please ask for customized solutions

Linear Lens Arrays for collimation / imaging of fiber bundles

Application: telecom components, optical switches, sensor

arrays

� 1x8, 1x12, 1x16 GRIN Rod Lens Arrays

� Pitches 250 (± 1) µm / 500 (± 1) µm

� Lens diameter: 240 (± 1) µm / 480 (± 1) µm

� Lens NA: 0.35 / 0.5 / 0.2

Please ask for customized solutions

Example:

lens diameter: 0.48 mm

v-groove array made by dicing in glass

pitch: 0.50 mm

Examples:

Fiber optic sensor

� mounted in stainless steel

tube

� GRIN lens diameter: 0.5 /

1.0 / 1.8 mm

� Tube diameter: 0.7 / 1.2 /

2.0 mm

� Side opening for prism

exit possible

2-D Lens Arrays

Application: multi-imaging sensors, read-out of biochips

Examples:

� 4x5 GRIN Rod Lens

� Array Pitch: 1.60 (± 0.01) mm

� Lens diameter: 1.0 mm

� Lens NA: 0.5

� Mount: machinable ceramic

� using glass ferrule and capillary

� GRIN lens diameter: 1.8 mm

� Capillary diameter: 2.8 mm

� Pitch: 4.50 (± 0.02) mm

� Lens diameter: 1.8 mm

� Lens NA: 0.5

� Mount: brass

� using glass ferrule, mounted in

stainless steel tube

� GRIN lens diameter: 0.5 / 1.0 /

1.8 mm

� Tube diameter: 0.7 / 1.2 / 2.0 mm

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15

GRIN fiber collimators



Please ask for customized solutions.

Applications: Fiber coupling, telecom components (e.g. Isolators, Circulators, WDM), Signal

processing …

� High beam quality (M² < 1.1) on compact size

� Customized beam diameter (waist) and waist position

� Low insertion loss / High return loss due to angled facets or/and AR coatings

� High pointing accuracy and pointing stability

� Active alignment of optical – to mechanical axis (e.g. stainless steel tube) on request

SMF Pigtail

17

In Vivo Medical Confocal Imaging and Optical Coherence Tomography

� GRIN Imaging systems

� Diameter: (0.35) / 0.5 mm / 1.0 mm / 1.8 mm / (2.0) mm

� Prisms to change the direction of view can be assembled

� Combination with optical fibers and imaging fiber bundles on request

� Optical design for customized solutions

� AR- and splitter (dichroic, polarizing, non-polarizing) coatings on request

� Mounted in stainless steel tubes on request

In Vivo Microendoscopy

In Vivo OCT Endoscopy

Examples:

image object

� Diameters: (0.35), 0.5, 1.0, 1.8, (2.0) mm

� Magnifications: 1:4.9 and 1:2.6

� Object NA: 0.5

� Resolution limit >0.7µm

� For standard configurations please see the datasheet “GRIN

Needle Endomicroscopes”

J. Neurosci. 26(41): 10380-6

Single Mode Fiber

Glass ferrule

GRIN rod lens

Prism

� Diameters: 0.5, 1.0, 1.8 mm

� working distance, spot size and divergence can be designed to

customized specifications

� Diffraction-limited Gaussian spots

� Generation of internal reference signal within probe possible

� Example: typical amplitude modulation of back reflected

interference signal in the fiber about 80 % (moving mirror as

reflector)

Tolerances GRIN lens:


diameter d: + 0 / - 0.01 mm




Surface quality:


The surface quality is defined within 90 % of the lens diameter. Outside of this area

defects are allowed

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18

Gradient Index (GRIN) Lenses

� GRIN rod lenses for fiber coupling

� GRIN cylindrical lenses for beam shaping of high power laser

diode bars and high brightness diodes

� easy to assemble due to the plane surfaces

� good off- and on-axis performance

� non-toxic silver and lithium ion exchange

A half-pitch lens images an object on the entrance surface inverted

to the exit surface of the lens.

A quarter-pitch lens images a point source on the entrance surface

of the lens into infinity or collimates it, respectively. This

configuration is usually applied to the collimation of single-mode

and multi-mode optical fibers and laser diodes. For high-power

laser diodes, GRIN cylindrical lenses are used for the Fast-Axis-

Collimation.

A 0.23-pitch lens images a point source placed in the working

distance s into infinity or collimates it (see Fig. 3).

d

zl

fs

Fig. 3. GRIN rod lens

The geometrical gradient constant g and the lens length zl

determines the focal length f and the working distance s of the

lens,

)gztan(gn

1s,

)gzsin(gn

1f

l0l0

==

Various imaging problems can be solved by choosing different lens

lengths zl (see Fig.4).

Fig. 4. Image formation by a GRIN focusing lens

The maximum acceptance angle of a GRIN collimating lens ϑ is

determined by the numerical aperture NA. As in fiber optics, it is

derived from the maximum index change of the GRIN profile,

)2/gd(sech1nnnNA)sin(2

02R

20 −=−==ϑ .

nR is the refractive index at the margin of the profile, and d is the

lens diameter or the lens thickness, respectively.

GRIN lenses with a high numerical aperture (NA ≈ 0.5) are

produced by silver ion exchange in a special glass which avoids

any coloration in the visible spectral range. The absorption edge of

the silver containing glass occurs at a wavelength of λ0.5 = 370

nm. GRIN lenses with low numerical aperture (NA ≤ 0.2) are

fabricated via lithium ion exchange. The absorption edge of the

glass being used is at a wavelength of λ0.5 = 235 nm.

Gradient Index Optics

GRIN lenses represent an interesting alternative to conventional

spherical lenses since the lens performance depends on a

continuous change of the refractive index within the lens material.

Instead of curved shaped surfaces only plane optical surfaces are

used. The light rays are continuously bent within the lens until

finally they are focussed on a spot.

Fig. 1 GRIN lens

Conventional spherical lens

The GRIN lenses are produced by silver ion exchange in a special

glass. The composition of the glass is protected by a patent. In

contrast to the conventionally used technology this is a non-toxic

process and bears no health and environmental risks for both the

producer as well as the user of these products. This process is

performed in rods and slabs resulting in rod lenses and cylindrical

lenses with plane optical surfaces.

A radial refractive index profile of nearly parabolic shape

)grsech(n)r(n 0=

realizes a continuos cosine ray trace within a GRIN focussing lens,

the period length z1-p of the lens is given by

g

2z p1

π=

−

and does not depend on the entrance height and the entrance

angle of the light ray (see Fig 2). n0 represents the refractive index

at the center of the profile, r the radius and g the gradient

constant.

Fig. 2. Ray traces within a GRIN focussing lens of different pitch lengths

The geometrical length of the particular lens zl is calculated from

the characteristic pitch of the lens P,

Pg

2zl

π=

Various imaging designs can be realized using the same index

profile by choosing different lens lengths:

A 1- (2, 3, or more, respectively)-pitch lens reproduces an object

placed in the entrance surface of the lens identically into the exit

surface.

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zl y, r

z

ssff

O

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P1 P2

I

19

Gradient Index Imaging Optics

� GRIN rod lenses and systems

� endoscopic and other miniaturized imaging applications

� easy to assemble due to the plane surfaces

� good off- and on-axis performance

� AR-coating on both sides possible

� non-toxic silver and lithium ion exchange

� low chromatic aberration

GRIN Objective Design

GRINTECH objective lenses are produced by non-toxic silver ion

exchange in glass and are suited for medical applications. The

large view angle of 60 degrees (± 30°) is obtained by a strong

index change within the glass material. The objective lenses image

the object plane in a working distance l (see Fig. 1) into the end

surface of the lens on a reduced scale.

Fig. 1 Image formation by a GRIN objective lens

The lenses are specified by the rod diameter d and the working

distance l (see the respective data sheet). The corresponding

magnification M and the necessary lens length zl are calculated by

,g

)glnarctan(z;

1lgn

1M 0l222

0

π+−=

+=

where n0 is the center index of the lens, and g is the gradient

constant of the lens. For each diameter, g can be calculated by

using the lens length of the respective lens type with infinite

working distance,

.z2

ginfl

π=

Beside standard working distances, customized lens designs can

be provided on request.

The dispersion of the index gradient causes a relative change of

the focal length as function of the wavelength. In the visible

range, the focal length of lenses with NA of 0.5 increases by

approx. 0.017 % per nm with rising wavelength. For objective

lenses of 1.0 mm diameter, the image plane of the blue light part

(440 nm) is located approx. 18 µm inside the lens. The image

plane of the red light part (650 nm) is located approx. 18 µm

outside the lens exit plane. For lenses of 0.5 mm diameter for

example, half of these image shift values is valid.

GRINTECH objective lenses are characterized by a small field

curvature. The image field is slightly bent inwards. For lenses of

1.0 mm diameter the field curvature is – 40 µm maximum at

90 % of the aperture, for 0.5 mm diameter – 20 µm maximum.

The barrel shaped distortion of the image increases up to approx.

14 % of the image height at the lens margin (see CCD-image

above).

The resolution limit of the objective lenses is on-axis approx.

400 lines per mm in white light.

GRIN Imaging Systems

Complete imaging systems for endoscopes and other applications

are fabricated by combining GRINTECH objective lenses, GRIN

relay lenses of customized pitch lengths, and prisms. Please

contact GRINTECH for customized solutions.

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ddA

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Contact:

- Herbert Stuermer

- Anke Kraeplin

GRINTECH GmbH

Schillerstrasse 1

07745 Jena

Germany

Phone: +49 (0) 36 41 / 22 76 0

Fax.: +49 (0) 36 41 / 22 76 11

[email protected]

www.grintech.de

Seite 00 Catalog Cover 15.12 pdf24Seite 01 Inhaltsverzeichnis 15.12 pdf24Seite 02 Image Grintech 18.12 pdf24Seite 03 Rod NA 05 18.12 pdf24Seite 04 Rod NA 032 15.12 pdf24Seite 05 Rod NA 02 15.12 pdf24Seite 06 Rod NA 02 high performance 15.12 pdf24Seite 07 Cylindrical Lens 21.12 pdf24Seite 08 Objective Lens 18.12 pdf24Seite 09 Endoscopic Systems 18.12 pdf24Seite 10 Hinweis Inscopix 15.12 pdf24Seite 11 Needle Endomicroscopes 15.12 pdf24Seite 12 High NA Fluorescence 15.12 pdf24Seite 13 High NA 2 Photon 15.12 pdf24Seite 14 High NA color corrected 15.12 pdf24Seite 15 Laser Line Generator 15.12 pdf24Seite 16 Lens Assemblies 15.12 pdf24Seite 17 Medical Imaging and OCT 15.12 pdf24Seite 18 Introduction GRIN Lens 15.12 pdf24Seite 19 Introduction Imaging Optics 15.12 pdf24Seite 20 Contact Information 15.12 pdf24

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