discover the endless opportunities technology can offer to
TRANSCRIPT
Discover the endless opportunities thistechnology can offer to your Brand.
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SoftgelConsumer PreferenceFACTS & INSIGHTS
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Overview:
Straus, Mike. Advances in softgels, capsules, and tablets are keeping these formats at the forefront
of the Industry. Nutritional Outlook. Nov 2018.
Lisa Schofield. Softgels’ Clear Advantages. Natural Products Insider. 2019
Copyright by Procaps S.A. 2021.
The softgel capsule has a strong recognition in the
supplement and the prescription market,
facilitating patient adherence to the drug by
facilitating swallowing thanks to the texture of its
shell.
The softgel capsule has been on the market
since the 19th century evolving to the present
day. Because of this consumers feel familiar with
the technology, trusting its efficiency, quality and
convenience.
The Softgel Capsule:A Superior Delivery System
System with wide-ranging applications
The Softgel Capsule is a solid dosage form composed of two gelatin films that contain semisolid or liquid APIs
protected by an external, hermetically sealed cover.
Softgels ensure high precision dosage by achieving homogeneity of ingredients.
An effective delivery system for oral drugs, especially those with low solubility and/or permeability (BCS class II, III and IV(1))
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1 BCS Class II – low solubility / high permeability.
BCS Class III – high solubility / low permeability.
BCS Class IV – low solubility / low permeability. Mattson Jack
2 Group survey to 300 consumers in 1999, Softgel capsules market
análisis & trends applications (October 2016)
Key SGC characteristics
Main SGC applications
Enhanced bioavailability of active ingredients
Attractive physical appearance
Greater Stability
Extended Shelf Life
Masks unpleasant odors and flavors
Consumer Preferred Dosage Form/ Easy to swallow
Variety of Shapes, Colors and Sizes
Nutritional: Supplements, vitamins, concentrates and other natural products
Pharmaceutical: Products for any type of indication (OTC and Rx)
Cosmeceuticals: Cosmetic products that have medicinal properties
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Impossible to Counterfeit
Softgels, a format that has continuously reinvented itself The softgel capsule responds to vegetarian consumer’s
demands. Cultural, religious, or personal preference reasons lead consumers to follow different free from diets.
Soft capsules made with non animal sources are available to satisfy consumers’ needs.
Softgels deliver the benefits of the formulation without unpleasant experience due to the enteric coats reducing
lingering aftertaste and reflux caused by some active
ingredients.
Compliance increases with fewer doses and fixed dose combination technology in Softgels is ideal to respond to
this. Non-adherence to a treatment is one of the
consequences of swallowing difficulties. Softgel capsules offer chewable options for consumers
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Consumer Perceptions &Market ImpactRelative to other Oral Dosage Forms
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Studies support that softgels are indeed consumers’ preferred dosage form.SOFTGELS
Since 1999 till today studies have continuously shown that:
Consumers consider SoftgelCapsules as highly desirable:
90%
82%
89%
Of Consumers prefer clear
softgels because they are
“easier to swallow” than other
hard dosage forms.
Consider softgel capsules as
”fast and effective action“**
Report that are easier to
digest**
Are willing to pay more
for products in softgel
form.
25%
*In 1999, the Mattson Jack Group polled approximately 300 consumers in six statescomparing preference of softgels versus other delivery forms.**Lisa Schofield. Softgels’ Clear Advantages. Natural Products Insider. 2019
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Consumers’ Preferred Dosage FormSOFTGELS
Softgel Capsules
Tablets
Chewable/Gummy
Hard-Shell Capsules
Sprays/ Inhales
Lozenges/Sublinguals
Powders/Effervescent
Liquids/Tonics/Bever
Source: Nutrition Bussiness Journal survey of 11,435 consumers conducted between 3/27/2014 and
4/8/2014 Source: GELITA Symposium: September 2014”
Least Favorite Most Favorite
“Please rank your preference for how to take your supplements from most liked to least
liked.”
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PreferencesCONSUMER
Table 3. Top five dosage forms by indication
Table 2. Dosage forms - Perceptions and preferences
Appears Easier to Swallow
Dosage FormAppears Longer Lasting
Second Choice
Appears to Act
Rapidly
First Choice
Last Choice
Headache
Dosage Form Chronic Pain
Cold/Flu Allergy Antacid VitaminLaxative
*Consumers could name more than one dosage form.
89Clear oval softgel
42Clear oblong softgel
23Gelatin-coated round tablet
19Two-piece, har-shell capsule
18Opaque oblong softgel
8Oblong compressed tablet
7Clear oval softgel
7Gelatin-coated oblong Tablet
72 10 10 2
67 30 40 10
7 11 14 7
33 41 13 9
16 21 7 8
6 21 6 13
11 19 4 39
3 25 5 12
89
78
78
59
59
71
68
67
60
60
77
76
73
55
54
63
62
59
52
49
69
65
64
15
45
52
45
45
38
39
71
67
65
16
47
10
30
11
41
21
21
19
25
Clear softgel
Geltab
Opaque softgel
Two-piece, har-shell capsule
Compressed tablet
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PreferencesCONSUMER
The survey confirms
preferences for particular dosage
forms and for softgels over other
dosage forms.
Overall preference was driven by
ease of swallowing, and
softgels were rated first by the
majority of respondents.
Consumers would be interested in various
products if these were available as
softgels rather than in their current oral dosage forms and
maybe willing to pay a premium for
softgel products.
Pharmaceutical scientists and
marketers should consider softgels as alternative dosage
forms when developing new compounds or considering life-
cycle management of existing products.
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SOFTGELSSensory Elements
Is Odor a determining factor when choosing a medicine?
Bad smell in a medicine has its
negative consequences in the
experience of consumption and
patient treatment.
Medicines that smell bad
are considered unpleasant.
It is associated with “bad conditions”.
Considered inefective.
Gelatin does not have any odor or flavor, masking any unpleasant smells.
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http://www.who.int/medicines/services/counterfeit/impact/TheNewEstimatesCounterfeit.pdf
*BMI RESEARCH. Colombia. Pharmaceuticals & healthcare report Q42016. Page 9. Page 45.
** http://psi-inc.org/spanish/counterfeitSituation.cfm
According to data
provided to the WHO
Impact project, 30-40% of
medicines in Latin
America are counterfeit.*
PSI (Pharmacutica Security
Institute) estimates that the
trend in the number of
counterfeiting incidents has
been systematically
increasing year by year
from 2011 to 2015. **
PSI placed Colombia
among the top 10
countries worldwide for
fake and counterfeit.**
Counterfeiting processes,
cannot have high-tech
processes.
This phenomenon, added
to the smuggling of
medicine distributed
throughout Colombia,
becomes a public health
problem and a threat to
the country’s pharma
sector. Drug trading
in the last 10
years.
SOFTGELManufacturing
SafetySoftgels are an example of a
pharmaceutical form where
counterfeiting is not feasible,
providing greater
confidence and security to
consumers.
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Light softgels / tablets transit faster than those of thesame size but heavier.
The FDA issued recommendations forgeneric manufacturers establishing
guidelines for improving the intake oforal solids.
Of those who have difficulty swallowing: -15% speak to to their doctors; 8% admits skipping a dose; 4% quits therapy.
Those who have difficulty swallowing blame the
overall size of the tablet.
The use of outer gelatin layers help when swallowing the tablet.
https://www.fda.gov/downloads/drugs/guidances/ucm377938.pdf
SOFTGELSSensory Elements
Is Size a determining factor when choosing a medicine?
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The Evolutionof Great Brands
Toward Softgel Formats
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Innovationthrough Product Portfolio
EXPANSION
SoftgelDerivations
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Enteric Coated softgels are the best way to stabilize acid-
sensitive drug products. This is because the API is not delivered
in the stomach and instead targets drug delivery in the small
intestine, which is preferred to treat intestinal disease,
improving tolerance and reducing afteraste,
Resists absorption in the stomach.
KEY ENTERIC COATED SOFTGELS CHARACTERISTICS:
Improves Patient acceptance – Avoidingreflux in pregnant women.
Masks unpleasant odors and flavors.
Chemical Stability: Oxygen and moistureprotection barrier that prevents Omega acidoxidation and Oxidation/Hydrolysis of thevitamins.
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Double coated for Better appereance.
Enteric-Clear Softgels use the Enteric-Coated Softgel method of
stabilizing acid-sensitive drugs, but it has a patient-appealing
aesthetic.
Consumers often prefer clear capsules over opaqie and this design
also means fewer steps in the development process, as no coating
is necessary.
KEY ENTERIC CLEAR SOFTGELS CHARACTERISTICS:
Greater Bioavailability
Rapid Apsorption
No fish aftertasre
Less irritation of digestive orpastric mucosa, due to itsapsorption at the intestinal level.
Exact Dosing
Physiscally Appealing
Impossible to Counterfeit
Life-Cycle Management Extension.
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As the leading Manufacturer of Softgel-Related
technologies, softgel offers unparalleled custom capsule
services. Design your very own Stripgels.
KEY STRIPGELS ADVANTAGES:
Physically Appealing
Completely Customizable
Brand Identification
New Customer Experience
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With
Reducegels,
receive full
strength and
power in
a smaller softgel
size.
KEY REUCEGELS ADVANTAGES:
Enables higher API concentrations in
smaller softgel
A solution for complex API formulations
A Capable of delivering single and
combination API formulations
Tamper-evident
KEY REDUCEGELS Consumer Benefits:
Ideal for Seniors and Children
Available in a variety of Colors, Shapes,
Sizes and Clarity
Suitable for Vegetarians
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A soft gelatin capsule with twist-o cap allows access to a
measured dose for topical and/or oral applications.
KEY TWISTELS ADVANTAGES:
Better Dosage Accuracy
Eliminates Contamination by repeat use
Improves Compliance
Improved Stability
KEY TWISTELS CONSUMER BENEFITS:
Portable On-The-Go
Easy to twist- Ideal for geriatric, pediatric
and veterinary use
Available in variety of Colors, Shapes,
Sizes and Clarity
No water needed
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A The softgel vaginal ovule or insert, Vaogels, was
designed mucoadhesive properties ti facilitate retention ofthe product in the vagina and availability of the active
ingredient in a site-specific manner.
KEY VAOGELS ADVANTAGES:
Conical shape for easy application
Softgel hydrophilic outer layer
Improves treatment efficiency
Greater Dissolution/Faster disintegration
Exact Dosage
Lipophilic Exipients for better vaginal adherence and efficacy
Gentle and Non-Irritating
Stable until Inserted
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UNIGELTM
Fixed dose combination in
softgels for Multi-dose therapies
G-TABSTM
Masking unpleasant tastes
and odors with our gelatin
coated tablets
VERSAGELTM
Versatile softgel
Technology free from
Animal Derivatives
FUNTRITIONTM
Delivering easy nutrition with a
variety of formulations in
Nutritional Gummies
CHEWGELSTM
Chewable softgels as a
new solution for kids
and consumers who
have difficulty
swallowing.
Propietary Innovative
Softgel TechnologiesFOR EVERY PATIENT/CONSUMER NEED:
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• “Damian, F.; Harati, M.; Schwartzenhauer, J.; Van Cauwenberghe, O.;Wettig, S.D. Challenges of Dissolution Methods Development for Soft Gelatin Capsules. Pharmaceutics 2021, 13, 214. https://doi.org/10.3390 Pharmaceutics13020214
• Straus, Mike. Advances in softgels, capsules, and tablets are keeping these formats at the forefront of the industry. Nutritional Outlook. Nov 2018.
• Source: Kaspar van den Dries. Debunking Myths And Misconceptions About Softgels. Pharmaceutical Online. 2020.
• Lisa Schofield. Softgels’ Clear Advantages. Natural Products Insider. 2019
Sources:
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portfolio visit:
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