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Discovery of Inhibitors of Microglial Neurotoxicity Acting Through Multiple Mechanisms Using a Stem-Cell-Based Phenotypic Assay Susanne Höing, York Rudhard, Peter Reinhardt, Michael Glatza, Martin Stehling, Guangming Wu, Christiane Peiker, Alexander Böcker, Juan A. Parga, Eva Bunk, Jens C. Schwamborn, Mark Slack, Jared Sterneckert, Hans R. Schöler Cell Stem Cell Volume 11, Issue 5, Pages 620-632 (November 2012) DOI: 10.1016/j.stem.2012.07.005 Copyright © 2012 Elsevier Inc. Terms and Conditions

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Page 1: Discovery of Inhibitors of Microglial Neurotoxicity Acting Through Multiple Mechanisms Using a Stem-Cell-Based Phenotypic Assay Susanne Höing, York Rudhard,

Discovery of Inhibitors of Microglial Neurotoxicity Acting Through Multiple Mechanisms Using a Stem-Cell-Based Phenotypic Assay 

Susanne Höing, York Rudhard, Peter Reinhardt, Michael Glatza, Martin Stehling, Guangming Wu, Christiane Peiker, Alexander Böcker, Juan A. Parga, Eva Bunk, Jens C. Schwamborn, Mark Slack, Jared Sterneckert, Hans R. Schöler 

Cell Stem Cell Volume 11, Issue 5, Pages 620-632 (November 2012)

DOI: 10.1016/j.stem.2012.07.005

Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 2: Discovery of Inhibitors of Microglial Neurotoxicity Acting Through Multiple Mechanisms Using a Stem-Cell-Based Phenotypic Assay Susanne Höing, York Rudhard,

Figure 1

Cell Stem Cell 2012 11, 620-632DOI: (10.1016/j.stem.2012.07.005) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 3: Discovery of Inhibitors of Microglial Neurotoxicity Acting Through Multiple Mechanisms Using a Stem-Cell-Based Phenotypic Assay Susanne Höing, York Rudhard,

Figure 2

Cell Stem Cell 2012 11, 620-632DOI: (10.1016/j.stem.2012.07.005) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 4: Discovery of Inhibitors of Microglial Neurotoxicity Acting Through Multiple Mechanisms Using a Stem-Cell-Based Phenotypic Assay Susanne Höing, York Rudhard,

Figure 3

Cell Stem Cell 2012 11, 620-632DOI: (10.1016/j.stem.2012.07.005) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 5: Discovery of Inhibitors of Microglial Neurotoxicity Acting Through Multiple Mechanisms Using a Stem-Cell-Based Phenotypic Assay Susanne Höing, York Rudhard,

Figure 4

Cell Stem Cell 2012 11, 620-632DOI: (10.1016/j.stem.2012.07.005) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 6: Discovery of Inhibitors of Microglial Neurotoxicity Acting Through Multiple Mechanisms Using a Stem-Cell-Based Phenotypic Assay Susanne Höing, York Rudhard,

Figure 5

Cell Stem Cell 2012 11, 620-632DOI: (10.1016/j.stem.2012.07.005) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 7: Discovery of Inhibitors of Microglial Neurotoxicity Acting Through Multiple Mechanisms Using a Stem-Cell-Based Phenotypic Assay Susanne Höing, York Rudhard,

Figure 6

Cell Stem Cell 2012 11, 620-632DOI: (10.1016/j.stem.2012.07.005) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 8: Discovery of Inhibitors of Microglial Neurotoxicity Acting Through Multiple Mechanisms Using a Stem-Cell-Based Phenotypic Assay Susanne Höing, York Rudhard,

Figure 7

Cell Stem Cell 2012 11, 620-632DOI: (10.1016/j.stem.2012.07.005) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 9: Discovery of Inhibitors of Microglial Neurotoxicity Acting Through Multiple Mechanisms Using a Stem-Cell-Based Phenotypic Assay Susanne Höing, York Rudhard,

Cell Stem Cell 2012 11, 620-632DOI: (10.1016/j.stem.2012.07.005) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions

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