discussion of the non-motor symptoms of parkinson diseasebeyond the shakes discussion of the...
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Beyond the Shakes
Discussion of the Non-Motor Symptoms of Parkinson Disease
Wissam Deeb, MDJan 12, 2019Annual Parkinson’s SymposiumNeuroChallenge: Foundation for Parkinson’s
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Breen KC, Drutyte G. Non-motor symptoms of Parkinson's disease: the
patient's perspective. J Neural Transm (Vienna). 2013 Apr;120(4):531-5.
doi:10.1007/s00702-012-0928-2.
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Cognitive
changes
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Early
visuospatial
deficits
strong
predictor of
dementia
development
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Multimodality
50%
60% in 10 years
Not confined to PDD
16%
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Neuro-
psychiatric
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Sleep
problems
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Autonomic
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Sexual
dysfunction
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Gut
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Dental problems (poor oral hygiene,
loss of teeth…)
Drooling (can lead to aspiration
pneumonia)
Decrease taste
Swallowing problems (aspiration
pneumonia and weight loss)
Nausea, early satiety, fullness,
gastroparesis (weight loss)
Constipation (abdominal pain, and
perforation)
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✓ Relamorelin (not enough
recruitment)
✓ Lubiprostone (Amitiza)
✓ Not studied in PD though
promising: Linaclotide and
Plecanatide
✓ Botulinum toxin or Botox
✓ Others under FDA emergency
use
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Double vision, mainly
when reading, can
be a problem
Double vision, mainly
when reading, can
be a problem
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Improves sleep and quality of life
Improves
cognition,
apathy,
fatigue Improves quality of life
Improves
depression, quality
of life, sleep
Improves sleep,
quality of life,
fatigue,
depression,
apathy, anxiety
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