disorders of immunity ii: autoimmune diseases
DESCRIPTION
DISORDERS OF IMMUNITY II: AUTOIMMUNE DISEASES. R. HUGO MARTÍNEZ LOZANO, M.D. Aug-12-2009. LEARNING OBJECTIVES. K & U: - GENERAL FEATURES - IMMUNOLOGIC TOLERANCE - MECHANISMS OF AUTOIMMUNITY THE MOST IMPORTANT CHARCT. OF: - LES - RA - SS - SYSTEMIC SCLEROSIS - PowerPoint PPT PresentationTRANSCRIPT
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DISORDERS OF DISORDERS OF IMMUNITY II: IMMUNITY II:
AUTOIMMUNE DISEASESAUTOIMMUNE DISEASES
R. HUGO MARTÍNEZ LOZANO, M.D.R. HUGO MARTÍNEZ LOZANO, M.D.
Aug-12-2009.Aug-12-2009.
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LEARNING OBJECTIVESLEARNING OBJECTIVES K & U:K & U:- GENERAL FEATURES- GENERAL FEATURES- IMMUNOLOGIC TOLERANCE- IMMUNOLOGIC TOLERANCE- MECHANISMS OF AUTOIMMUNITY- MECHANISMS OF AUTOIMMUNITY- THE MOST IMPORTANT CHARCT. OF:THE MOST IMPORTANT CHARCT. OF: - LES- LES - RA- RA - SS- SS - SYSTEMIC SCLEROSIS- SYSTEMIC SCLEROSISRef: 223-239 & lecture’s informationRef: 223-239 & lecture’s information
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GENERAL FEATURESGENERAL FEATURES
FRECUENCY:FRECUENCY: DISEASE VS NORMALITYDISEASE VS NORMALITY
(Pathologic vs physiologic autoimm.)(Pathologic vs physiologic autoimm.)
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CRITERIA FOR DX OF CRITERIA FOR DX OF AUTOIMMUNE DISEASESAUTOIMMUNE DISEASES
AUTOIMMUNE REACTIONAUTOIMMUNE REACTION NOT SECONDARY TO TISSUE NOT SECONDARY TO TISSUE
DAMAGEDAMAGE NO OTHER CAUSENO OTHER CAUSE
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IMMUNOLOGIC TOLERANCEIMMUNOLOGIC TOLERANCE
CENTRAL: DEATH OF SELF-R LYMPHCENTRAL: DEATH OF SELF-R LYMPH (APOPTOSIS)(APOPTOSIS) PERIPHERAL:PERIPHERAL: - ANERGY: NO COSTIMULATORS B7- ANERGY: NO COSTIMULATORS B7 INHIBITORY R CTLA-4INHIBITORY R CTLA-4 - SUPPRESSION BY REGULATORY T - SUPPRESSION BY REGULATORY T - CLONAL DEL. BY ACTIVATION OF - CLONAL DEL. BY ACTIVATION OF INDUCED CELL DEATH (FASL-FAS)INDUCED CELL DEATH (FASL-FAS)
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MECHANISMS OF AUTOIMMUNE DIS. ROLES: - GENETICS - INFECTION/INFLAMMATION
MUTATIONS:-AIRE-CTLA-4-ETC.
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ROLE OF INFECTIONS
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ROLE OF INFECTIONS
C. EPITOPE EXPOSITION & SPREAD.
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SLE: GENERAL FEATURESSLE: GENERAL FEATURES
INCIDENCE: 1:700INCIDENCE: 1:700 SEX: 9:1SEX: 9:1 ETHNIC GROUPETHNIC GROUP AGE:AGE:
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CLINICAL CRITERIA:CLINICAL CRITERIA:(TABLE 6-8. p. 228)(TABLE 6-8. p. 228)
MALAR RASHMALAR RASH DISCOIDE RASHDISCOIDE RASH PHOTOSENSITIVITYPHOTOSENSITIVITY ORAL ULCERSORAL ULCERS ARTHRITISARTHRITIS SEROSITISSEROSITIS RENAL INVOLVEMENTRENAL INVOLVEMENT ANAANA ETC.ETC.
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ANAANA
GENERICGENERIC ANTI-DOBLE-STRANDED DNAANTI-DOBLE-STRANDED DNA ANTI-SMITH (Sm)ANTI-SMITH (Sm) ANTIHISTONE (DRUG-INDUCED LE)ANTIHISTONE (DRUG-INDUCED LE) SS-A & B (RNP)SS-A & B (RNP) ANTICENTROMERE (CREST)ANTICENTROMERE (CREST)
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RISK FACTORSRISK FACTORS
GENETICGENETIC ENVIRONMENTALENVIRONMENTAL IMMUNOLOGICIMMUNOLOGIC
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PATHOGENESIS:VASCULITIS(PHASES)
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Lupus erythematosus: skin.
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SKIN: ANTI-B.M. INJURY
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Idem.
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IDEM: (IMMUNEFLUORESCENCE)
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Malar rash