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DIVISION OF NEUROSURGERY UCL QUEEN SQUARE INSTITUTE OF NEUROLOGY 2018 ANNUAL REPORT

Vision

To develop and implement novel, safe, and effective treatments to advance

neurosurgical care.

Mission

The Division of Neurosurgery in the UCL Queen Square Institute of Neurology,

through its close partnership with the National Hospital for Neurology and

Neurosurgery, is committed to advancing neurosurgical care for the current and

next generations of patients through world class research, excellent training and

education, and top quality clinical care.

UCL NEUROSURGERY ANNUAL REPORT 2018

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Contents

Division Head’s Report ..................................................................................................................................... 2

Clinical Activity .................................................................................................................................................. 3

Grants ............................................................................................................................................................... 4

Awards .............................................................................................................................................................. 5

Publications ...................................................................................................................................................... 6

Presentations .................................................................................................................................................. 11

Organisation of Courses and Symposia .......................................................................................................... 16

Public Engagement Activities & Scientific Advisory Boards ............................................................................ 19

Other Professional Activities .......................................................................................................................... 20

2018 Victor Horsley Lecture ........................................................................................................................... 21

Departmental Contact Details ........................................................................................................................ 22


2

Division Head’s Report

In the practice of medicine, particularly at an Academic Health Sciences Centre, it is essential to

combine excellence in-patient care with continuous academic enquiry: it is as crucial that we develop

newer and safer treatments for our future patients as it is that we treat our patients of today with the

best available therapies. To this end, we focus on three overlapping academic pillars in the Division of

Neurosurgery at the UCL Queen Square Institute of Neurology: research into the mechanisms of

diseases and treatments, developing new tools for treating our patients, and clinical research

evaluating the impact of our treatments. Each of these areas have been expanding in recent years.

The foundation for each of these academic endeavours is, of course, our patients. In 2018, we opened

2 new operating theatres, bringing our total to 6 plus our intraoperative MR unit. Our operative activity

is thus continuing to increase: a snapshot of our activity in the Victor Horsley Department of

Neurosurgery at Queen Square is presented in the pages that follow.

From an academic perspective, many of our sub-specialty areas are well represented in various

international forums. Our academic training programme is expanding, with several of our trainees

currently pursuing PhDs. Overall, we continue to enhance our meaningful academic productivity.

We gained two new professors in 2018, as David Choi and Ludvic Zrinzo were each promoted. We also

had a retirement in 2018, with Professor Marwan Hariz returning to his not-so-native Umeå, Sweden,

where he will continue to participate in the functional neurosurgery programme. We are indebted to

Prof Hariz for his 16 year leadership of the Functional Neurosurgery Unit, expanding the unit to be the

largest in the UK, and establishing a solid international leadership position in safety and excellence in

DBS surgery and clinical research. We wish Marwan the best in this next stage of his life.

I look forward to further enhancement of our academic mission in 2019.


3

Clinical Activity

In this year’s annual report, we highlight our very active cranial neuro-oncology services: in 2018, a total of

742 oncological operations were done in 2018. In the coming years, we aim to expand our academic

productivity. To this end, we play an active part in the BRC neuro-oncology sub-theme, where we aim to

combine multiple data to further understand gliomas. Our pituitary group has been developing new tools

for pituitary surgery, and will be expanding this work in 2019. Here is a snapshot of our clinical activity:

Chart 1: High-Grade Tumours - total 291

Chart 2: Low-Grade Tumours – total 451

GBM IV, 133

Metastasis, 89

Astrocytoma III, 15

Lymphoma, 15

Other High Grade Tumour, 13

Oligodendraglioma III, 11

Chordoma, 6

Medulloblastoma IV, 6

Chondrosarcoma, 3

Other, 69

Pituitary Adenoma, 152

Meningioma I and II, 162

Other Low-Grade Glioma, 30

Astrocytoma II, 22

Oligodendraglioma II, 18

Ependymoma, 8

Haemangioblastoma I, 8

Schwannoma I, 51

Other, 137


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Grants

New Grants Awarded

PRINCIPLE INVESTIGATORS

Harith Akram: European Society for Stereotactic and Functional Neurosurgery (ESSFN): to Build a Universal Tool

for Thalamic Segmentation for Tremor Surgery. €20,000. 2018.

Rob Brownstone and Jonathan Shapey: UCL Therapeutics Acceleration Support Fund: Novel Multimodality

Imaging Techniques for Neurosurgical Planning and Stereotactic Navigation in Lateral Skull Base Surgery: A

Feasibility Study £73,477. 2018 – 2019.

CO-INVESTIGATORS Harith Akram: NIHR University College London Hospitals Biomedical Research Centre (Grant number BRC-536):

Advanced Neuroimaging to Study the Central Pain Pathways in Trigeminal Neuralgia (Tic Douloureux) Pre and

Post-Microvascular Decompression (ANTIC). £17.798. 2018 – 2019.

Rob Brownstone: Medical Research Council (co-investigator, PI: M. Beato): Beyond the Neuromuscular Junction:

Dysfunction of Spinal Synaptic Targets of Motoneurons in Amyotrophic Lateral Sclerosis. £577,470. 2018 – 2020.

On-going Grants

PRINCIPLE INVESTIGATORS Rob Brownstone: Wellcome Trust Investigator Award. Tuning Spinal Motoneurons for Movement. £2,512,185 +

IRS £950,000. 2016 – 2021.

Rob Brownstone: UCLH - National Institute for Health Research University College London Hospitals. Biomedical

Research Centre Neuro-oncology Theme. £122,490. 2017 – 2021.

COLLABORATORS Rob Brownstone and Andrew McEvoy: Wellcome EPSRC Centre for Surgical and Interventional Sciences, co-

investigators (PI: S. Ourselin), £13,130,284. 2017-2022.


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Awards

Harith Akram, Supervised by Zrinzo L: 19th annual Queen Square Symposium 2018; post-upgrade PhD prize,

sponsored by Addgene. “Towards Connectomic Functional Neurosurgery.”

Hani Marcus: Queen Square Clinical Governance Committee Annual Audit Competition. “Informed Consent in

Patients Undergoing Transsphenoidal Surgery.” First Prize.

Hani Marcus: Royal College of Surgeons of England - Margaret Witt Scholarship Fund for Clinical Excellence.

£1000.

Craven, C. supervised by Watkins LD and Toma AK: 10th International Society for Hydrocephalus and

Cerebrospinal Fluid Disorders, Bologna, October. “Brain Tissue Oxygen Monitoring and CSF diversion.” Young

Investigator Award.

Mediratta S, supervised by Watkins LD and Toma AK: 10th International Society for Hydrocephalus and

Cerebrospinal Fluid Disorders, Bologna, October. “The Effect of CSF Flow Blockage on the Surgical Management

and Outcomes of Chiari Malformation.” Young Investigator Award.


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Publications

Peer-reviewed Papers

CEREBROVASCULAR Alg VS, Ke X, Grieve J, Bonner S, Walsh DC, Bulters D, Kitchen N, Houlden H, Werring DJ. Genetics and

Observational Subarachnoid Haemorrhage (GOSH) Study Investigators. Association of functional MMP-2 gene

variant with intracranial aneurysms: case-control genetic association study and meta-analysis. Br J Neurosurg.

2018 Jun; 32(3):255-259. doi: 10.1080/02688697.2018.1427213. Epub 2018 Jan 15.

Hostettler IC, Alg VS, Shahi N, Jichi F, Bonner S, Walsh D, Bulters D, Kitchen N, Brown MM, Houlden H, Grieve J,

Werring DJ; Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study investigators. Characteristics

of Unruptured Compared to Ruptured Intracranial Aneurysms: A Multicenter Case-Control Study. Neurosurgery.

2018 Jul 1; 83(1):43-52. doi: 10.1093/neuros/nyx365.

Smedley A, Yusupov N, Almousa A, Solbach T, Toma AK, Grieve JP. Management of incidental aneurysms:

comparison of single Centre multi-disciplinary team decision making with the unruptured incidental aneurysm

treatment score. Br J Neurosurg. 2018 Oct; 32(5):536-540. doi 10.1080/02688697.2018.1468019. Epub 2018 May

15. PubMed PMID: 29764206.

CSF Asif H, Craven CL, Siddiqui AH, Shah SN, Matloob SA, Thorne L, Robertson F, Watkins LD, Toma AK. Idiopathic

intracranial hypertension: 120-day clinical, radiological, and manometric outcomes after stent insertion into the

dural venous sinus. J Neurosurg. 2018 Sep; 129(3):723-731. doi: 10.3171/2017.4.JNS162871. PubMed PMID:

28984521.

Chari A, Karponis D, Craven CL, Khan AA, Thorne L. Disproportionately Large Communicating Fourth Ventricle:

Pearls for Diagnosis and Management. Cureus. 2018 Nov 5;10(11):e3547. doi: 10.7759/cureus.3547. PubMed

PMID: 30648079; PubMed Central PMCID: PMC6324856.

Craven CL, Baudracco I, Thompson SD, Thorne L, Watkins LD, Toma AK. Transtentorial Distortion Syndrome:

Consistent Complication Following Lateral and Fourth Ventricular Shunting in Adults. World Neurosurg. 2018 Feb;

110:e514-e519. doi: 10.1016/j.wneu.2017.11.032. PubMed PMID: 29155115.

Dasgupta D, D'Antona L, Aimone Cat D, Toma AK, Curtis C, Watkins LD, Thorne L. Simulation workshops as an

adjunct to perioperative care bundles in the management of external ventricular drains: improving surgical

technique and reducing infection. J Neurosurg. 2018 Oct 1:1-5. doi: 10.3171/2018.5.JNS172881. Epub 2018 Oct

1. PubMed PMID: 30497209.

Funnell JP, Craven CL, D'Antona L, Thompson SD, Chari A, Thorne L, Watkins LD, Toma AK. Intracranial pressure

in patients with papilloedema. Acta Neurol Scand. 2018 Aug; 138(2):137-142. doi: 10.1111/ane.12922. Epub

2018 Mar 12. PubMed PMID: 29532475.

Funnell JP, Craven CL, Thompson SD, D'Antona L, Chari A, Thorne L, Watkins LD, Toma AK. Pulsatile versus non-

pulsatile tinnitus in idiopathic intracranial hypertension. Acta Neurochir (Wien). 2018 Oct; 160(10):2025-2029.

doi: 10.1007/s00701-018-3587-8. Epub 2018 Jul 16. PubMed PMID: 30014363.


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FUNCTIONAL Akram H, Dayal V, Mahlknecht P, Georgiev D, Hyam J, Foltynie T, Limousin P, De Vita E, Jahanshahi M, Ashburner

J, Behrens T, Hariz M, Zrinzo L. Connectivity derived thalamic segmentation in deep brain stimulation for tremor.

Neuroimage Clin 2018;18:130–42.

Akram H, Matharu M, Zrinzo L. Author response: Optimal deep brain stimulation site and target connectivity for

chronic cluster headache. Neurology 2018 Jul 24;91(4):194–4.

Blomstedt P, Hariz M. The paper that wrote itself-A ghost story. Mov Disord. John Wiley & Sons, Ltd; 2018

Sep;33(9):1509–10.

Blomstedt P, Stenmark Persson R, Hariz G-M, Linder J, Fredricks A, Häggström B, Philipsson J, Forsgren L, Hariz M.

Deep brain stimulation in the caudal zona incerta versus best medical treatment in patients with Parkinson's

disease: a randomised blinded evaluation. Journal of Neurology, Neurosurgery & Psychiatry. 2018 Jul;89(7):710–

6.

Brownstone RM and Chopek JW; (2018) Reticulospinal systems for tuning motor commands. Front. Neural

Circuits 12:30. doi: 10.3389/fncir.2018.00030.

Brownstone RM and Lancelin C; (2018) Escape from homeostasis: Spinal microcircuits and progression of

amyotrophic lateral sclerosis. Journal of Neurophysiology 119:1782-1794.

Chircop C, Dingli N, Aquilina A, Zrinzo L, Aquilina J. MRI-verified “asleep” deep brain stimulation in Malta through

cross border collaboration: clinical outcome of the first five years. Br J Neurosurg. 2018 Aug;32(4):365–71.

Chopek JW, Nascimento F, Beato M, Brownstone RM, and Zhang Y; (2018) Sub-populations of spinal v3

interneurons form focal modules of layered pre-motor microcircuits. Cell Reports 25(1):146-156.e3. doi:

10.1016/j.celrep.2018.08.095. (* lead author.)

Dayal V, Grover T, Limousin P, Akram H, Cappon D, Candelario J, Salazar M, Tripoliti E, Zrinzo L, Hyam J, Jahanshahi

M, Hariz M, Foltynie T. The Effect of Short Pulse Width Settings on the Therapeutic Window in Subthalamic

Nucleus Deep Brain Stimulation for Parkinson's disease. J Parkinsons Dis 2018;8(2):273–9.

Fischer P, Chen CC, Chang Y-J, Yeh C-H, Pogosyan A, Herz DM, Cheeran B, Green AL, Aziz TZ, Hyam J, Little S,

Foltynie T, Limousin P, Zrinzo L, Hasegawa H, Samuel M, Ashkan K, Brown P, Tan H. Alternating Modulation of

Subthalamic Nucleus Beta Oscillations during Stepping. J. Neurosci. 2018 May 30;38(22):5111–21.

Gratwicke J, Zrinzo L, Kahan J, Peters A, Beigi M, Akram H, Hyam J, Oswal A, Day B, Mancini L, Thornton J, Yousry

T, Limousin P, Hariz M, Jahanshahi M, Foltynie T. Bilateral Deep Brain Stimulation of the Nucleus Basalis of

Meynert for Parkinson Disease Dementia: A Randomized Clinical Trial. JAMA Neurol 2018 Feb 1;75(2):169–78.

Grover T, Georgiev D, Kaliola R, Mahlknecht P, Zacharia A, Candelario J, Hyam J, Zrinzo L, Hariz M, Foltynie T,

Limousin P, Jahanshahi M, Tripoliti E. Effect of Low versus High Frequency Subthalamic Deep Brain Stimulation on

Speech Intelligibility and Verbal Fluency in Parkinson's Disease: A Double-Blind Study. J Parkinsons Dis 2018 Dec

28;21(Suppl 14):1–11.

Hassan S, Lagrata S, Levy A, Matharu M, Zrinzo L. Microvascular decompression or neuromodulation in patients

with SUNCT and trigeminal neurovascular conflict? Cephalalgia. 2018 Feb;38(2):393–8.


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Huang Y, Green AL, Hyam J, FitzGerald J, Aziz TZ, Wang S. Oscillatory neural representations in the sensory

thalamus predict neuropathic pain relief by deep brain stimulation. Neurobiology of Disease. 2018 Jan;109(Pt

A):117–26.

Huotarinen A, Kivisaari R, Hariz M. Laitinen's Subgenual Cingulotomy: Anatomical Location and Case Report.

Stereotact Funct Neurosurg. 2018;96(5):342–6.

Mahlknecht P, Georgiev D, Akram H, Brugger F, Vinke S, Zrinzo L, Hariz M, Bhatia KP, Hariz G-M, Willeit P, Rothwell

JC, Foltynie T, Limousin P. Parkinsonian signs in patients with cervical dystonia treated with pallidal deep brain

stimulation. Brain 2018 Oct 1;141(10):3023–34.

Martinez-Ramirez D, Jimenez-Shahed J, Leckman JF, Porta M, Servello D, Meng F-G, Kuhn J, Huys D, Baldermann

JC, Foltynie T, Hariz MI, Joyce EM, Zrinzo L, Kefalopoulou Z, Silburn P, Coyne T, Mogilner AY, Pourfar MH, Khandhar

SM, Auyeung M, Ostrem JL, Visser-Vandewalle V, Welter M-L, Mallet L, Karachi C, Houeto J-L, Klassen BT,

Ackermans L, Kaido T, Temel Y, Gross RE, Walker HC, Lozano AM, Walter BL, Mari Z, Anderson WS, Changizi BK,

Moro E, Zauber SE, Schrock LE, Zhang J-G, Hu W, Rizer K, Monari EH, Foote KD, Malaty IA, Deeb W, Gunduz A,

Okun MS. Efficacy and Safety of Deep Brain Stimulation in Tourette Syndrome: The International Tourette

Syndrome Deep Brain Stimulation Public Database and Registry. JAMA Neurol 2018 Mar 1;75(3):353–9.

Momin S, Mahlknecht P, Georgiev D, Foltynie T, Zrinzo L, Hariz M, Zacharia A, Limousin P. Impact of Subthalamic

Deep Brain Stimulation Frequency on Upper Limb Motor Function in Parkinson's Disease. J Parkinsons Dis

2018;8(2):267–71.

Roy HA, Pond D, Roy C, Forrow B, Foltynie T, Zrinzo L, Akram H, Aziz TZ, FitzGerald JJ, Green AL. Effects of

pedunculopontine nucleus stimulation on human bladder function. Neurourol. Urodyn. 2018 Feb;37(2):726–34.

Thom M, Liu J, Bongaarts A, Reinten RJ, Paradiso B, Jäger HR, Reeves C, Somani A, An S, Marsdon D, McEvoy A,

Miserocchi A, Thorne L, Newman F, Bucur S, Honavar M, Jacques T, Aronica E. Multinodular and vacuolating

neuronal tumors in epilepsy: dysplasia or neoplasia? Brain Pathol. 2018 Mar; 28(2):155-171. doi:

10.1111/bpa.12555. Epub 2017 Sep 19.

Torrecillos F, Tinkhauser G, Fischer P, Green AL, Aziz TZ, Foltynie T, Limousin P, Zrinzo L, Ashkan K, Brown P, Tan

H. Modulation of Beta Bursts in the Subthalamic Nucleus Predicts Motor Performance. J. Neurosci. 2018 Oct

10;38(41):8905–17.

Whatley BP, Chopek JW, Hill R, and Brownstone RM; (2018). Case Studies in Neuroscience: Evidence of motor

thalamus reorganization following bilateral forearm amputations. Journal of Neurophysiology 120:1776-1780.

doi: 10.1152/jn.00120.2018.

Zrinzo L. Systematic Stereotactic Error Reduction Using a Calibration Technique in Single-Brain-Pass and

Multitrack Deep Brain Stimulations. Oper Neurosurg 2018 Nov 28;15(1):72.

NEURO-ONCOLOGY Champeaux C, Jecko V, Houston D, Thorne L, Dunn L, Fersht N, Khan AA, Resche-Rigon M. Malignant Meningioma:

An International Multicentre Retrospective Study. Neurosurgery. 2018 Dec 19. doi: 10.1093/neuros/nyy610.

Llewellyn H, Neerkin J, Thorne L, Wilson E, Jones L, Sampson EL, Townsley E, Low JTS. Social and structural

conditions for the avoidance of advance care planning in Neuro-oncology: a qualitative study. BMJ Open. 2018

Jan 31;8(1):e019057. doi: 10.1136/bmjopen-2017-019057.


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PITUITARY

Marcus HJ, Jain A, Grieve J, Dorward NL. Informed consent for patients undergoing transsphenoidal excision of

pituitary adenoma: Development and evaluation of a procedure-specific online educational resource. World

Neurosurgery. 2018; 118: e933-937.

Marques P, Barry S, Ronaldson A, Ogilvie A, Storr HL, Goadsby PJ, Powell M, Dang MN, Chahal HS, Evanson J,

Kumar AV, Grieve J, Korbonits M. Emergence of Pituitary Adenoma in a Child during Surveillance: Clinical

Challenges and the Family Members' View in an AIP Mutation-Positive Family. Int J Endocrinol. 2018 Apr 4;

2018:8581626. doi: 10.1155/2018/8581626. eCollection 2018.

SPINAL

Lui Jonathan YC, Sayal P, Prezerakos G, Russo V, Choi D, Casey ATH. The surgical management of dysphagia

secondary to diffuse idiopathic skeletal hyperostosis. Clin Neurol Neurosurg. 2018 Apr; 167:36-42. doi:

10.1016/j.clineuro.2018.02.010. Epub 2018 Feb 7.

Prezerakos GK, Sayal P, Kourliouros A, Pericleous P, Ladas G, Casey A. Paravertebral tumours of the

cervicothoracic junction extending into the mediastinum: surgical strategies in a no man's land. Eur Spine J. 2018

Apr 27(4):902-912. doi: 10.1007/s00586-018-5512-5. Epub 2018 Feb 14.

GENERAL

Cheng, J., Korte, N., Nortley, R., Sethi, H., Tang, Y., & Attwell, D. Targeting pericytes for therapeutic approaches

to neurological disorders. Acta Neuropathologica. 2018. https://doi.org/10.1007/s00401-018-1893-0.

Craven CL, Cooke M, Rangeley C, Alberti SJMM, Murphy M. Developing a pediatric neurosurgical training model.

J Neurosurg Pediatr. 2018 Mar;21(3):329-335. doi: 10.3171/2017.8.PEDS17287. PubMed PMID: 29271733.


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Book Chapters

Hyam JA and Zrinzo L: “Stereotactic Functional Neurosurgery for Mental Health Disorders, Pain, and

Epilepsy.” Published in R. G. Ellenbogen, L. N. Sekhar, & N. Kitchen (Eds.), Principles of Neurological Surgery

(4th ed., pp. 781-798). Elsevier, Philadelphia, PA, February 2018.

Zrinzo L and Hyam JA: “Deep Brain Stimulation for Movement Disorders.” Published in R. G. Ellenbogen, L. N.

Sekhar, & N. Kitchen (Eds.), Principles of Neurological Surgery (4th ed., pp. 781-798). Elsevier, Philadelphia,

PA, February 2018.

Vakharia V and Marcus HJ: “The Robotic Arm Guidance System: Applications and Limits”. In: Delfini R.,

Landi A., Mancarella C., Gregori F. (Eds.) Modern Thoraco-Lumbar Implants for Spinal Fusion. Springer,

Cham, 2018.

Books

Harith Akram: Author of “Application of MRI Connectivity in Stereotactic Functional Neurosurgery” ISBN 978-1-

5272-2779-8. Published by the Unit of Functional Neurosurgery, Queen Square Institute of Neurology. 2018.

Jonathan Hyam: Editor of “Surgery of the Autonomic Nervous System”, Hyam et al. (Eds.) Oxford University Press;

BMA Book Awards, Highly Commended in the Surgical Specialities category of the British Medical Association

Book Awards 2017; Surgical Book of the Year, runner-up. 2018.

Other

Hani Marcus: Currently acting as Editor the first book on Neurosurgical Robotics by Springer, with a publication

date planned in Feb 2020.


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Presentations

International

3RD DBS AND 9TH NEURO-ENGINEERING WORKSHOP, LINKOPING UNIVERSITY, SWEDEN, FEBRUARY: Tractography and DBS.

Presenter: Harith Akram.

ASSOCIATION OF SURGEONS IN TRAINING CONFERENCE, EDINBURGH, UK, APRIL:

Multidisciplinary Management of Paediatric Traumatic Brain Injury (TBI): A Regional Retrospective Cohort Study.

Presenters: Paine H, Marcus HJ, and Wilson M.

AMERICAN ASSOCIATION OF NEUROLOGICAL SURGEONS (AANS), NEW ORLEANS, USA, APRIL:

Neurosurgery for Obsessive-Compulsive Disorder.

Presenter: Ludvic Zrinzo.

34TH CONGRESS OF PORTUGUESE NEUROSURGICAL SOCIETY, COIMBRA, PORTUGAL, MAY: Towards Connectomic Functional Neurosurgery.

Presenter: Harith Akram (keynote speaker).

40TH INTERNATIONAL SYMPOSIUM OF THE GRSNC, MONTREAL, CANADA, MAY:

From Conductor to C(H)Ord: Orchestrating Recovery of Motor Function.

Presenter: Rob Brownstone.

MECHANISMS OF DEXTEROUS BEHAVIOR, JANELIA, USA, MAY:

Spinal Microcircuits for Regulating Paw Function.


CELL BIOLOGY SYMPOSIUM, UMEÅ, SWEDEN, MAY:

Can C-Bouton-Motoneuron Synapses Get Any More Exciting?


ESPN CONFERENCE, BONN, GERMANY, MAY:

Robot-Assisted Stereotactic Brainstem Biopsy in Children: Prospective Cohort Study.

Presenters: Marcus HJ, Dawes W, Tisdall M, and Aquilina A.

COMPUTER ASSISTED ROBOTIC SURGERY CONFERENCE, BERLIN, GERMANY, JUNE:

Preclinical Assessment of A Novel Intraoperative Ultrasound Probe for Transsphenoidal Surgery.

Presenters: Mihcin S, Marcus HJ, Delaunay R, Maneas E, Xia W, Ourselin S, Desjardins A, Dorward N, and

Vercauteren T.


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AMERICAN ASSOCIATION OF STEREOTACTIC AND FUNCTIONAL NEUROSURGERY (ASSFN), DENVER, USA, JUNE:

“Image-Verified” Surgery that Allows “Asleep” DBS is the New Standard.


AMERICAN ASSOCIATION OF STEREOTACTIC AND FUNCTIONAL NEUROSURGERY (ASSFN), DENVER, USA, JUNE: Primer on Advanced Neuroimaging Analyses. Presenter: Harith Akram.

INTERNATIONAL CONFERENCE OF THE ROYAL COLLEGE OF PSYCHIATRISTS, BIRMINGHAM, UK, JUNE:

Contemporary Neurosurgery for Psychiatric Disorders: A Neurosurgical perspective.


EUROPEAN SOCIETY FOR STEREOTACTIC AND FUNCTIONAL NEUROSURGERY, EDINBURGH, UK, SEPTEMBER:

Structural Connectivity: Overview. Presenter: Harith Akram. Parkinsonian Signs in Patients with Cervical Dystonia Treated with Pallidal Deep Brain Stimulation: A Controlled

and Observer-Blinded Study.


Brain Networks Implicated in Ventral Capsule and Anteromedial Subthalamic Nucleus Stimulation for Refractory

Obsessive-Compulsive Disorder.


BREAKING BARRIERS IN HEALTHCARE; UNIVERSITY OF MALTA MULTIDISCIPLINARY CONFERENCE, MALTA,

SEPTEMBER:

Breaking Healthcare Barriers: Hope versus Hype in the Age of “Fake News”.


10TH MEETING OF THE INTERNATIONAL SOCIETY FOR HYDROCEPHALUS AND CEREBROSPINAL FLUID DISORDERS,

BOLOGNA, ITALY, OCTOBER:

Radiographic Markers of Disturbances in CSF Dynamics: Correlating Imaging with 24-Hour ICP Monitoring.

Presenters: Asif H, Craven CL, Thorne L, Watkins LD, Toma AK.

Long-Term Outcomes for Venous Sinus Stenting for IIH.

Presenters: Asif H, Craven CL, Thorne L, Watkins LD, Toma AK.

CSF Diversion Strategies for Persistent Cranial Pseudomeningocoeles.

Presenters: Craven CL, Asif H, Thompson S, Ramos J, D’Antona L, Watkins LD, Toma AK.

CSF Drainage Increases Brain Oxygen Tension after Subarachnoid Haemorrhage.

Presenters: Craven CL, Reddy U, Thorne L, Watkins LD, Toma AK.

Shunting Slit Ventricles: A Comparison of the Parieto-Occipital Vs Frontal Approach.

Presenters: Craven CL, D’Antona L, Thompson S, Ramos J, Sennik S, Watkins LD, Toma AK.

Neuro-Sarcoidosis Presenting with Normal Pressure Hydrocephalus.

Presenters: Kafai A*, Craven CL*, Thorne L, Watkins LD, Toma AK.

The Effect of CSF Flow Blockage on the Surgical Management and Outcomes of Chiari Malformation.

Presenters: Mediratta S, D’Antona L, Craven CL, Thorne LT, Watkins LD, Toma AK.


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Formulating Infection Control Guidelines for Lumbar Drain Insertion Following Subarachnoid Haemorrhage.

Presenters: Sennik, S, Craven CL, D’Antona L, Asif H, Thompson S, Ramos J, Dawes W, Thorne LT, Watkins LD,

Toma AK.

SOCIETY FOR NEUROSCIENCE, CALIFORNIA, USA, NOVEMBER:

Therapeutic Effect of l-DOPA and Deep Brain Stimulation for Advanced Parkinson’s disease is Associated with

Unique Network Hubs.


MOTOR NEURONE DISEASE ASSOCIATION 29TH INTERNATIONAL SYMPOSIUM, GLASGOW, UK, DECEMBER:

(Plenary Lecture) Beyond Molecules: Could Circuit Pathophysiology Contribute to Progression Of ALS.


THE NEURAL BASES OF ACTION – FROM CELLULAR MICROCIRCUITS TO LARGE-SCALE NETWORKS AND

MODELLING, ERICE, ITALY, DECEMBER:

The Role of Spinal Cord in the Control of Movement.


Regional

BRITISH SKULL BASE SOCIETY MEETING, LIVERPOOL, UK, JANUARY:

Robotics in Endoscopic Skull Base Surgery.

Presenter: Hani Marcus.

BRITISH NEUROVASCULAR GROUP MEETING, LONDON, UK, MARCH:

Predicting Vasospasm with Headache Scores.

Presenters: Craven CL*, Kafai A*, Stephen T, Davis S, Rollinson V, Watkins LD, Toma AK.

SOCIETY OF BRITISH NEUROLOGICAL SURGEONS SPRING MEETING, TORQUAY, UK, APRIL:

Ventricular Catheter Placement in IVH: What is the Evidence Behind the Dogma of Laterality?

Presenters: Asif H, Craven CL, Thompson S, D’Antona L, Watkins LD, Toma AK.

Automated Volume and Pressure Controlled CSF Drainage for IVH: A Single Centre Experience.

Presenters: Asif H, Craven CL, Thompson S, D’Antona L, Watkins LD, Toma AK.

SVP in IIH: Towards Non-Invasive Monitoring.

Presenters: D’Antona L, Thompson S, Craven CL, Thorne LT, Watkins LD.

CSF Flow Studies in Chiari Malformation.

Presenters: Mediratta S, D’Antona L, Craven CL, Thompson S, Watkins LD, Toma AK.

Facial Recognition in NPH is Impaired.

Presenters: Sennik S, Craven CL, Thompson S, D’Antona L, Watkins LD, Toma AK.


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BRAIN REPAIR AND REHABILITATION, UCL QUEEN SQUARE INSTITUTE OF NEUROLOGY, LONDON, UK, MAY:

Early Experience of Parenchymal Brain Oxygen Monitoring.

Presenters: Craven CL, Reddy U, Watkins LD and Toma AK.

ABN/SBNS JOINT ANNUAL MEETING, LONDON, UK, SEPTEMBER:

Advances in Deep Brain Stimulation (invited talk).


Update on Neurosurgical Techniques used in Functional Neurosurgery (Plenary session).


Experience of Tunnelled Vs. Bolt Evds on the Intensive Care Unit.

Presenters: Asif H, Craven CL, Reddy U, Watkins LD, Toma AK.

Trials and tribulations in spine surgery

Presenter: Adrian Casey.

The Role of Surgery in the Management of Spinal Hypermobility.

Presenter: Adrian Casey.

Brain Parenchymal Oxygen Monitoring in Delayed Cerebral Ischaemia.

Presenters: Craven CL, Reddy U, Asif H, Watkins LD, Toma AK.

Treatment Implications of Parkinson’s Disease in Normal Pressure Hydrocephalus.

Presenters: Funnell JP, Craven CL, D’Antona L, Thorne L, Toma AK, Watkins LD.

Use of Adjustable Anti-Gravity Devices in NPH Patients with Delayed Post-Shunt Deterioration.

Presenters: Funnell JP, Craven CL, D’Antona L, Thorne L, Toma AK, Watkins LD.

Neurosarcoidosis Presenting with Normal Pressure Hydrocephalus: Case Series.

Presenters: Kafai A*, Craven CL*, Thorne L, Watkins LD, Toma AK.

The Art and Craft of Neurosurgery (Sir Victor Horsley Lecture).

Presenter: Neil Kitchen.

Improved Prediction of Surgical Resectability in Patients with Glioblastoma Multiforme using an Artificial Neural

Network.

Presenters: Marcus AP, Marcus HJ, Camp SJ, Nandi D, Kitchen N, and Thorne L.

Computer-Assisted Versus Manual Planning for Stereotactic Brain Biopsy: Retrospective Comparative Pilot Study.

Presenters: Marcus HJ, Vakharia VN, Sparks R, Rodionov R, Kitchen N, McEvoy AW, Miserocchi A, Thorne L,

Ourselin S, and Duncan JS.

Implementation of Duty of Candour Regulation within Neurosurgery: A National Cross-Sectional Survey.

Presenters: Marcus HJ, Sayal P, Kitchen N, Surajit B, and Thorne L.

Informed Consent for Patients Undergoing Transsphenoidal Excision of Pituitary Adenoma: Development and

Evaluation of a Procedure-Specific Online Educational Resource.

Presenters: Marcus HJ, Jain A, Grieve J, and Dorward NL.

Sphenopalatine Ganglion Stimulation for Chronic Cluster Headache.

Current and Novel Surgical Treatment of Epilepsy (Lifelong learning session).

Presenters: Andrew McEvoy and Anna Miserocchi.

Cranio-Cervical Instability in Ehlers-Danlos Syndrome Employing Upright, Dynamic MR Imaging; A Comparative

Study.

Presenter: Georgios Prezerakos.

Prevalence of Normal Pressure Hydrocephalus in Falls Clinic Patients.


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Presenters: Sennik, S, Craven CL, D’Antona L, Asif H, Dawes W, Thorne L, Toma AK, Watkins LD.

Vestibular Dysfunction in Acute Traumatic Brain Injury.

Presenters: Tsang K, Marcus HJ, Paine H, Sargeant M, Sykes E, Saviour M, Arthur J, Sawhney A, Wolstenholme S,

Collins K, Morroney N, Rakkar-Thomas S, Hussain A, Arshad Q, Jones B, Smith R, Wilson MH, Seemungal BM.


Poster Presentations

BRITISH NEUROVASCULAR GROUP MEETING, LONDON, UK, MARCH:

Subarachnoid Haemorrhage in Over 70s: A Single Centre Experience.

Presenters: Asif H*, Craven CL*, Stephen T, Davis S, Rollinson V, Watkins LD, Toma AK.

SOCIETY OF BRITISH NEUROLOGICAL SURGEONS SPRING MEETING, TORQUAY, UK, APRIL:

Awake ICP Monitoring: The Patient Experience.

Presenters: Asif H, Goel A, Craven CL, Thompson D, D’Antona L, Toma AK, Watkins LD, Thorne L.

Recognition of Clinical Features in DCI: Time for a Checklist.

Presenters: Craven CL*, Kafai A, Stephen T, Davis S, Rollinson V, Watkins LD, Toma AK.

QUEEN SQUARE SYMPOSIUM, LONDON, UK, MAY: Towards Connectomic Functional Neurosurgery.



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Organisation of Courses and Symposia 20TH CLINICOPATHALOGICAL CONFERENCE IN PITUITARY DISEASE, LONDON, UK, FEBRUARY: Audience approximately 120. Mainly UK based endocrinologists and pituitary surgeons.

Organising committee and Faculty: Neil Dorward, Joan Grieve and Hani Marcus.

HAMLYN SYMPOSIUM ON MEDICAL ROBOTICS, LONDON, UK, JUNE: The Symposium attracted over 500 delegates last year and now in its 12th year, it has become a leading

international conference on medical robotics, current clinical practice and emerging technologies in robotic

surgery.

Organising committee: Hani Marcus.

ASECULAP COURSE: COMPLEX HYDROCEPHALUS MANAGEMENT. THE JOURNEY – NEW BORN TO THE ELDERLY, LONDON, UK, SEPTEMBER: Approximately 30 attendees from various units within the UK, consisting of specialist nurses and physicians with

interest in managing complex hydrocephalus.

Organiser: Thompson ST.

Faculty: Claudia Craven, Lewis Thorne, Ahmed Toma, Laurence Watkins and GOSH consultants.

XXIII CONGRESS OF THE ESSFN (EUROPEAN SOCIETY FOR STEREOTACTIC AND FUNCTIONAL NEUROSURGERY, EDINBURGH, UK, SEPTEMBER: One of the main topics for the meeting was neurosurgical approaches to the treatment of psychiatric disorder

and for the first time, this meeting was jointly organised with a psychiatrist (Keith Matthews). Held over 4 days,

this meeting was attended by over 850 delegates from Europe. North and South America, Africa, Asia and

Australia, making it the largest such congress to date.

Organisers: Marwan Hariz and Ludvic Zrinzo.

WHITE FIBRE DISSECTION AND 3D ANATOMY OF HUMAN BRAIN, LONDON, UK, SEPTEMBER: A course aimed to understand in great depth eloquent areas of cerebral cortex, the important pathways, the

complex anatomy of the deeper structures and the ventricles in a three dimensional way. Aimed at Consultants

and Neurosurgical trainees. We had national and international faculty and participants from all over the country.

It was free for all candidates and we had a very positive feedback. Approved by SBNS: 10 CPD points.

Organiser: Huma Sethi.

CAUDA EQUINA TIPS AND TRICKS, LONDON, UK, SEPTEMBER: The course aimed to understand in great depth the anatomy of cauda equina, surgical principles to deal with this

emergency, various techniques to repair CSF leak and litigations involved. Aims at higher and early years

Neurosurgical trainees. Great opportunity to pair higher surgical trainees with early years so that the former could

teach the later and get a certificate on practical teaching. We had a very positive feedback. It was free for all

trainees. Approved by SBNS: 6 CPD points.



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ADVANCED COMMUNICATION SKILLS IN NEURO ONCOLOGY: CONSENT, DUTY OF CANDOUR, BREAKING THE BAD NEWS, MEDICOLEGAL ASPECTS, LONDON, UK, OCTOBER: Held at the General Medical Council. A course aimed to equip doctors for difficult conversations with patients.

Real life scenarios were explored to further develop critical leadership qualities and skills for positive impact. Key

learning was best practice approaches that work when breaking bad news. Aimed at Neurosurgical trainees. It

was well attended with very positive feedback. It was free for all participants. Approved by SBNS: 5 CPD points.


MRI-GUIDED AND MRI-VERIFIED DBS COURSE ON BEHALF OF THE ECMT (EUROPEAN CONTINUING MEDICAL TRAINING), LONDON, UK, OCTOBER: Attended by neurosurgeons, neurologists and neuro-radiologists, this course includes didactic lectures and

attendance to multidisciplinary clinics as well as deep brain stimulation surgeries in the interventional iMRI Suite.

Approved by the Royal College of Surgeons: 12 CPD points.

Course Director: Ludvic Zrinzo.


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Faculty Participation in Courses

FIFTH ANNUAL DEEP BRAIN STIMULATION NURSE ASSOCIATION (DBSNA) CONFERENCE, LONDON, UK, MARCH: Faculty member: Ludvic Zrinzo.

INTERNATIONAL DBS ACADEMY - A ROUNDTABLE DISCUSSION WITH INTERNATIONAL DBS EXPERTS ABOUT ADVANCEMENTS IN DBS THERAPY, PARIS, FRANCE, JUNE: Faculty member: Harith Akram.

2ND SPEECH AND SWALLOWING IN PARKINSON'S DISEASE SCHOOL, ON BEHALF OF THE MOVEMENT DISORDER SOCIETY, LONDON, UK, JULY: Faculty member: Ludvic Zrinzo.

INTERNATIONAL DBS ACADEMY - A ROUNDTABLE DISCUSSION WITH INTERNATIONAL DBS EXPERTS ABOUT ADVANCEMENTS IN DBS THERAPY, LONDON, UK, SEPTEMBER: Faculty members: Harith Akram and Ludvic Zrinzo.

ADVANCED DEEP BRAIN STIMULATION FOR MOVEMENT DISORDERS COURSE ON BEHALF OF THE INTERNATIONAL PARKINSON & MOVEMENT DISORDER SOCIETY, LONDON, UK, NOVEMBER: Faculty member: Ludvic Zrinzo.


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Public Engagement Activities & Scientific Advisory Boards

Public Engagement

Hani Marcus: Science of Surgery Event at the Wellcome / EPSRC Centre for Interventional and Surgical Sciences.

Ahmed Toma: Idiopathic Intracranial Hypertension (IIH) Priority Setting Partnership.

Scientific Advisory Boards

Rob Brownstone: Brain Research UK, Chair in Neurosurgery.

Joan Grieve: Member of Independent Data Monitoring and Ethics Committee – for Dex-CSDH and Rescue - ASDH

trials.

Hani Marcus: Member of Advisory Group on Robotic Surgery. Royal College of Surgeons of England.

Ahmed Toma: UK CSF advisory group.

Ludvic Zrinzo: Member of the educational subcommittee of the ESSFN.

Ludvic Zrinzo: Member of the ESSFN subcommittee on pedunculopontine nucleus DBS surgery.

Ludvic Zrinzo: Member of the subcommittee on psychiatric surgery of the World Society.

Other

Rob Brownstone: Trustee of Stoke Mandeville Spinal Research.

Rob Brownstone: External review panel, Department of Neuroscience, University of Copenhagen.

Joan Grieve: Elected council member of Society of British Neurosurgeons.

Joan Grieve: Trustee of the National Brain Appeal.

Ahmed Toma: Member of the International Society for Hydrocephalus and Cerebrospinal Fluid Disorders.


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Other Professional Activities

Huma Sethi: Regional Director Royal College of Surgeons (North-East London).

Huma Sethi: Royal College of Surgeons Assessor.

Huma Sethi: Royal College of Surgeons Faculty.

Huma Sethi: Panel member for National Neurosurgery Selection Committee.

Huma Sethi: Question writer for Neurosurgery FRCS exam.


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2018 Victor Horsley Lecture Visualization of Cerebrospinal Fluid Movement with Spin Labelling at MR Imaging in Normal and Pathophysiologic Conditions Dr. Shinya Yamada

Chief of Neurosurgery, Toshiba Rinkan Hospital, Japan.

About Dr. Shinya Yamada

Dr. Yamada is chief neurosurgeon at the Toshiba Rinkan Hospital in Japan. His main research topics are hydrocephalus and cerebrospinal fluid (CSF) movement. Dr Yamada worked in the brain physiology laboratory at Brown University with Prof. Helen Cserr, whose discovery of interstitial fluid physiology is now known as a part of the glymphatic system. In 2004, Dr Yamada discovered that CSF fluid motion could be visualised using MRI arterial spin labeling techniques, in which CSF itself can be used as internal tracer. This technique allows for the non-invasive study of CSF movement in various regions without contrast administration. He now applies this MRI sequence to study CSF dynamics in people with normal brains and CSF-related disorders, and has found that CSF dynamics are far different from what was thought. The technique has also proven to be clinically useful to observe CSF flow before and after treatment of patients with hydrocephalus.

About Sir Victor Horsley

Horsley (1857-1916) was the first neurosurgeon appointed to the National Hospital Queen Square, and was known worldwide as the ‘Father of Neurosurgery’. He was also a brilliant experimentalist, elected as FRS at the age of 29 years for his work on cerebral localization and comparative anatomy. He pioneered neurosurgery for epilepsy, tumours, abscesses, head injuries, spinal and pituitary diseases, and trigeminal neuralgia. He devised a stereotactic frame and a variety of new surgical techniques and technologies. His work was not limited to neurosurgery: he made significant contributions to the understanding of rabies, thyroid disease, vaccines, antisepsis, anaesthesia, and military medicine. He was an iconoclast and social reformer, active in the Temperance Movement, a supporter of female suffrage, health care of the working class, vivisection, and medical reform. He stood for Parliament and served as president of the British Medical Association and was on the General Medical Council. He won the Gold Medal of the Royal Society, and was knighted in 1902. He worked to reform the medical services of the British Army and died on active duty, the only casualty of the First World War amongst the National Hospital senior staff.

The meeting celebrated the enduring legacy of one the greatest National Hospital doctors.


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Departmental Contact Details

Contact Information

Professor Robert Brownstone

Brain Research Trust Chair of Neurosurgery

Head of Division

Email: [email protected]

PA Contact Information:

Alice Winters

Email: [email protected]

Phone: 020 3108 9649

Departmental Address

Division of Neurosurgery

UCL Queen Square Institute of Neurology

University College London

Queen Square

London, UK

WC1N 3BG

divi division of neurosurgery ucl queen square … · craven cl, baudracco i, thompson sd, thorne...

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