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Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreading process. Copyright © 2016 the authors This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version. Research Articles: Neurobiology of Disease DNA-PKcs, ATM and ATR interplay maintains genome integrity during neurogenesis. Vanessa Enriquez-Rios 1,2,4 , Lavinia C. Dumitrache 1,4 , Susanna M. Downing 1,4 , Yang Li 1 , Eric J. Brown 3 , Helen R. Russell 1 and Peter J. McKinnon 1,2 1 Department of Genetics, St Jude Children's Research Hospital, Memphis, TN 38105 2 College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA 3 Abramson Family Cancer Research Institute and the Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. DOI: 10.1523/JNEUROSCI.4213-15.2016 Received: 23 November 2015 Revised: 14 November 2016 Accepted: 26 November 2016 Published: 15 December 2016 Author contributions: V.E.-R., L.C.D., and P.J.M. designed research; V.E.-R., L.C.D., S.D., Y.L., and H.R. performed research; V.E.-R., L.C.D., S.D., Y.L., E.B., H.R., and P.J.M. analyzed data; V.E.-R. and P.J.M. wrote the paper; E.B. contributed unpublished reagents/analytic tools. 4 Equal contributions. Correspondence: [email protected], Department of Genetics, St Jude Children's Research Hospital, Memphis, TN 38105 Cite as: J. Neurosci 2016; 10.1523/JNEUROSCI.4213-15.2016 Alerts: Sign up at www.jneurosci.org/cgi/alerts to receive customized email alerts when the fully formatted version of this article is published.

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Page 1: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreadingprocess.

Copyright © 2016 the authors

This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version.

Research Articles: Neurobiology of Disease

DNA-PKcs, ATM and ATR interplay maintains genome integrity duringneurogenesis.

Vanessa Enriquez-Rios1,2,4, Lavinia C. Dumitrache1,4, Susanna M. Downing1,4, Yang Li1, Eric J. Brown3, Helen R.

Russell1 and Peter J. McKinnon1,2

1Department of Genetics, St Jude Children's Research Hospital, Memphis, TN 381052College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN 38163,USA3Abramson Family Cancer Research Institute and the Department of Cancer Biology, Perelman School ofMedicine, University of Pennsylvania, Philadelphia, PA 19104.

DOI: 10.1523/JNEUROSCI.4213-15.2016

Received: 23 November 2015

Revised: 14 November 2016

Accepted: 26 November 2016

Published: 15 December 2016

Author contributions: V.E.-R., L.C.D., and P.J.M. designed research; V.E.-R., L.C.D., S.D., Y.L., and H.R.performed research; V.E.-R., L.C.D., S.D., Y.L., E.B., H.R., and P.J.M. analyzed data; V.E.-R. and P.J.M. wrotethe paper; E.B. contributed unpublished reagents/analytic tools.

4Equal contributions.

Correspondence: [email protected], Department of Genetics, St Jude Children's Research Hospital,Memphis, TN 38105

Cite as: J. Neurosci 2016; 10.1523/JNEUROSCI.4213-15.2016

Alerts: Sign up at www.jneurosci.org/cgi/alerts to receive customized email alerts when the fully formattedversion of this article is published.

Page 2: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

1Department of Genetics, St Jude Children’s Research Hospital, Memphis, TN 38105, 2College of Graduate Health Sciences, University of Tennessee Health Science Center,

Memphis, TN 38163, USA; 3Abramson Family Cancer Research Institute and the Department of Cancer Biology, Perelman School of Medicine, University of

Pennsylvania, Philadelphia, PA 19104. 4Equal contributions.

5Correspondence: , Department of Genetics, St Jude

Children’s Research Hospital, Memphis, TN 38105

Integrating DNA-PKcs, ATM and ATR neural function.

Page 3: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

PRKDC

Page 4: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

in vitro

Page 5: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

PRKDC

Page 6: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

PRKDC

Page 7: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Atm p53 Atr

Prkdc

Prkdc

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.

Page 8: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Page 9: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

In situ

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.

Page 10: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Prkdc-/-

Page 11: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Prkdc-/-

Prkdc-/-

Page 12: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Prkdc-/-

Prkdc-/-

Prkdc-/-

Prkdc-/-

Prkdc-/-

Prkdc-/-

Page 13: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Prkdc-/-

Prkdc-/-

Page 14: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Prkdc-/-

Prkdc-/-

AtmNes-cre

Prkdc-/- AtmNes-cre

Prkdc-/-

Page 15: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Prkdc-/-

Prkdc-/-

Prkdc-/-

Prkdc-/-

Prkdc-/-

Prkdc-/-

Prkdc-/-

Page 16: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Prkdc-/-

Prkdc-/-

Prkdc-/-

Prkdc-/-

AtmNes-cre Prkdc-/- AtmNes-cre

Prkdc-/-

Page 17: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Prkdc-/- AtmNes-cre Prkdc-/- AtrNes-

Prkdc-/- Atm;Atr)Nes-cre

Prkdc-/-

AtmNes- Prkdc-/- Atm;Atr)Nes-

AtrNes-cre

Prkdc-/-

AtmNes-cre

Page 18: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Prkdc-/-

AtmNes-cre

Atm Atr

Prkdc-/- AtmNes-cre

Prkdc-/-

Page 19: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

in vivo

Prkdc-/- AtmNes-cre

AtrNes-cre

Page 20: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

AtrNes-cre

Prkdc-/- AtmNes- -/- AtrNes-cre (Atm;Atr)Nes-cre Prkdc-/- Atm;Atr)Nes-

Prkdc-/-;AtrNes-cre

Page 21: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Prkdc-/-

Page 22: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Prkdc-/-

Prkdc-/-

Prkdc-/-

AtrNes-cre

Page 23: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

PRKDC

Page 24: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Page 25: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Prkdc

Page 26: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Page 27: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Page 28: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Page 29: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Page 30: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Page 31: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Page 32: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Prdkc-/-

Prdkc-/-

Prkdc-/-

Prdkc-/-

Prkdc-/-

Page 33: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Prdkc-/-

Prdkc-/-

Prdkc-/-

Prdkc-/-

Prdkc-/-

Prdrkc-/-

Prkdc-/-

AtmNes-cre

Page 34: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Prkdc-/-

Prkdc-/-

Prkdc-/-

Prkdc-/-

Prkdc-/-

Prkdc-/-

Prkdc-/-

Prkdc-/-

Prkdc-/-

Prkdc-/-

AtmNes-cre

Page 35: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

Prkdc-/-

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p< p

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Page 36: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

AtmNes-cre Atr;Atm)Nes-cre

(Atm;Atr;p53)Emx1-cre;Prkdc-/

AtrNes-cre

ATR ATM PRKDC

Page 37: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Integrating DNA-PKcs, ATM and ATR neural function”

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Page 38: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr
Page 39: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr
Page 40: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr
Page 41: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr
Page 42: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr
Page 43: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr
Page 44: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr
Page 45: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr
Page 46: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr
Page 47: DNA-PKcs, ATM and ATR interplay maintains genome … :rrgelqhhwdo srt +rzwkhvhwkuhhnlqdvhvfroohfwlyho\frruglqdwhwkhuhvsrqvhvw r'1$gdpdjh sru zlwklqdsk\vlrorjlfdofrqwh ... atm and atr

Research Paper ATM independent, high fidelity ... · Research Paper 1 under homologous end joining (NHEJ) [6]. Ataxia telangiectasia mutated (ATM), ATM and Rad3-related (ATR), and

ATR BROCHURE

EUROPEAN AVIATION SAFETY AGENCY … 42...EUROPEAN AVIATION SAFETY AGENCY Operational Evaluation Board Report Cabin Crew Evaluation ATR 42 and ATR 72 (ATR 42/72) (ATR 42-300/-500/-600

Engineering Geology...AAU Office of the Registrar De 't: Civil En ineerin Program: Section: 4 course Code; CENG ID.NO ATR12152]05 ATR/5749/05 ATR/4526/05 ATR/7587/06 ATR/2774/05 ATR/5278/05

SH - Pokemon Go Type Effectiveness Chart for PvP Go Type... · 7\SH:HDN WR PRUH GDPDJH WDNHQ 6XSHUHIIHFWLYH WR PRUH GDPDJH GHDOW Fire Water Water Flying Ground Steel Fire Fire Normal

Yeast ATM and ATR kinases use different mechanisms to ......2020/08/14  · Yeast ATM and ATR kinases use different mechanisms to spread histone H2A phosphorylation around a DNA double-strand

Arabidopsis SIAMESE-RELATED Cyclin-Dependent Kinase … · found that SMR induction mainly depends on ATM and SOG1, rather than ATR, as would be expected for a drug that triggers

TRANSPORT CANADA MMEL SUPPLEMENT TO ATR 42 / ATR 72 … · 2015. 8. 12. · DRAFT TRANSPORT CANADA Master Minimum Equipment List Supplement ATR 42 / ATR 72 Page: II Revision: 04 13

ATR 42-500 - Pakistan International Airlinescrewserver1.piac.com.pk/Documents/Manual/ATR42/ATR.42... · 2019. 10. 17. · Doc# FOD/NASP(ATR)/01 ATR-42 Edition 1 SPECIAL OPERATIONS

Atr Selectivity

ATR Aircraft | Home - FLIGHT CREW TRAINING SOLUTIONS...FPT ATR 72-500 ATR 72-600 JOHANNESBURG FFS ATR 42-300 / 500 ATR 72-200 / 500 FPT ATR 72-500 SINGAPORE FFS ATR 72-600 FPT ATR

Cell cycle checkpoint signaling through the ATM and ATR ...genesdev.cshlp.org/content/15/17/2177.full.pdf · REVIEW Cell cycle checkpoint signaling through the ATM and ATR kinases

Agency Technical Review Guidance for Cost Engineering Products · ATR reviewer and may perform ATR review (para 6.2.2) ATR Lead prepares an ATR Team Provide District $4,000-$6,000

ATR 60 P ATR 68 P - Region and Language | Ammann 60 P ATR 68 P PREMIUM RAMMERS BUILT TO MEET THE HIGHEST STANDARDS The Premium ATR 60P and ATR 68P rammers are built to fulfill the

ATM ATM Layer.ppt

OPERATIONAL EVALUATION REPORT ATR GIE A T ATR · PDF file“ATR-600” is the commercial designation used by ATR to refer to the basic ... tricycle landing gear, ... Operational Evaluation

ATR Theory and ATR Performance Analysis and Predictionjao/Talks/InvitedTalks/SPIE...ATR Theory and ATR Performance Analysis and Prediction Joseph A. O’Sullivan Electronic Systems

atr kinase

Medium-Term Debt Management Strategy (MTDS)mof.gov.eg/MOFGallerySource/.../Medium-Term_Debt_Management_Strategy.pdf · 2 Acronyms ATM Average Time to Maturity (years) ATR Average

Additional power for your fused accessories · Title: Bussmann series ATC, ATM and ATR fuse blocks product profile No. 10527 Subject: Features and benefits of the Bussmann series

ATR . DIFFERENCES - Amazon Web Servicess3.gta.s3-eu-west-1.amazonaws.com/files/221/221/atr-.-differences.pdf · Pilots already qualifiedon an ATR 42 or ATR 72 airplane ... • ATR

InterplaybetweenROSandAutophagyinCancerandAging:From … · 2019. 8. 4. · Some DNA damage sensors, such as FOXO3a, ATM, ATR, and p53, are important autophagy regulators, and autophagy

National Air & Space Museum Technical Reference Files ... · ATR, General Documents Drawer AA, Folder 780005-01 ATR ATR 42 Documents Drawer AA, Folder 780015-01 ATR ATM 42R Documents

Theory of structures II - AAiT CIVIL structures il io no. atr/s910/05 atr/4413/05 atr/3soo/05 atr/3957/05 atr/5s49/os atr/1520/os atr/4234/05 atr/2492/d5 atr/z636/05 atr/3245/05 atr/3227/0s

Atr Systems

Budding Yeast ATM/ATR Control Meiotic Double-Strand Break ... · Meiotic DSBs are essential for meiosis; nevertheless, each break represents a potentially lethal or mutagenic DNA

Involvement of Host ATR-CHK1 Pathway in Hepatitis B Virus ...(ATM) pathway and the ATM and Rad3-related (ATR) pathway, in HBV CCC DNA for-mation was thus investigated. Inhibition,

WATERPROOF 3 ATM 5 ATM 10 ATM 20 ATM - 30 ATM · WATERPROOF 3 ATM 5 ATM 10 ATM 20 ATM - 30 ATM Perspiration Hand washing - Car washing Shower or bath - Spatters Under the rain -Swimming

Analysis of the ATR-Chk1 and ATM-Chk2 pathways …eprints.whiterose.ac.uk/120079/7/s41598-017-07366-7.pdfAgostino Gemelli, 10, 00168, Rome, Italy. Anna Di Benedetto, Cristiana Ercolani,

Antenna Test Range (ATR) - projects …projects-web.engr.colostate.edu/ece-sr-design/AY17/ATR/docs/ATR E... · Antenna Test Range (ATR) Objectives and Constraints Abstract Design

ATR Limitations

PC/Mac - aerosoft-shop.com · 6.6 Electrical System ... 6.11 Fuel System ... The ATR 72 is the stretched version of the ATR 42 (which has capacity . ATR 72-500. ATR 72-500

atr family

Interplay between ATM and ATR for the regulation of cellular responses to DNA … · 2016. 5. 15. · ATM and ATR are key players in checkpoint response and their activations are

DNA-PKcs, ATM, and ATR Interplay Maintains Genome ... · García-Muse, 2012; McKinnon, 2013). To ensurenormalneuraldevelopment,thereis ... DNA damage-responsive kinases cooperatively