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Do Now. Explain the difference between transcription and translation. (Hint: Think about what is made) Explain difference between codon and anticodon . 3. After answering the above questions get out a piece of scratch paper. What is the protein for the DNA strand below?. - PowerPoint PPT PresentationTRANSCRIPT
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Do Now1. Turn in Alien Invasion (staple sheets together)2. Get out Protein Synthesis HW3. Explain the difference between transcription and
translation. (Hint: Think about what is made)4. Explain difference between codon and
anticodon.After answering the above questions get out a piece
of scratch paper.
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What is the protein for the DNA strand below?
TAATACAGGTTGCGTACT
AUUAUGUCCAACGCAUGA
MET SER ASN ALA STOP
TRANSCRIPTION
TRANSLATION
DNA
RNA
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Protein Synthesis ReviewVideo
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MutationsMutations
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What is a mutation?
Change in the DNA nitrogen base
sequence of a gene
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How do Mutations Occur?
Errors in DNA Replication
Replication
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How do Mutations Occur?
Damaged DNA caused by
agents such as sunlight, smoke,
radiation
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How do we get mutations????
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Two ways to classify mutations
Acquired mutation
Get a mutation at some point in life.
Hint: Think of it like getting sick, but you
can’t get rid of it.
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Two ways to classify mutations
Inherited mutation
Get a mutation from your
parents
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Let’s practice protein synthesis with normal DNA
DNA: TAC AAC GTC ACC ATT
mRNA: AUG UUG CAG UGG UAA
Amino acid: Met Leu Gln Trp STOP
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Category of Mutation: Point Change in one base of the DNA sequence.
Original: The fat cat ate the wee rat
Point mutation: The fat hat ate the wee rat
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Example of Point Mutation: Sickle Cell Anemia
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Sickle Cell Anemia: Point Mutation
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Sickle Cell Anemia Story(Beginning to 3:00)
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Category of Mutation: Frameshift Addition or deletion of a DNA base resulting
in a different sequence of DNA.
Original: The fat cat ate the wee rat
Frameshift mutation: The fat ata tet hew eer at
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Example of Frameshift Mutation: Tay Sachs
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Tay Sachs Disease: Frameshift Mutation
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Type of Mutations: Missense Change in one base of the DNA sequence
which causes a change in amino acid.
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Mutated Example of Missense
DNA: TAC AAG GTC ACC ATT
mRNA: AUG UUC CAG UGG UAA
Amino acid: Met Phe Gln Trp STOP
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Type of Mutations: Nonsense Change in one base of the DNA sequence
which codes for a STOP codon
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Mutated Example of Nonsense
DNA: TAC AAC GTC ACT ATT
mRNA: AUG UUG CAG UGA UAA
Amino acid: Met Phe Gln STOP
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Type of Mutations: SilentChange in one base of the DNA sequence which
has no effect on the amino acid sequence
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Mutated Example of Silent
DNA: TAC AAT GTC ACC ATT
mRNA: AUG UUA CAG UGG UAA
Amino acid: Met Leu Gln Trp STOP
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Type of Mutations: InsertionAddition of one or more bases into a DNA
sequence
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Mutated Example of Insertion
DNA: TAC AAC CGT CAC CAT T
mRNA: AUG UUG GCA GUG GUA A
Amino acid: Met Leu Gly Val Val
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Type of Mutations: DeletionThe removal of one or more bases in DNA
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Mutated Example of Deletion
DNA: TAC AAC GCA CCA TT
mRNA: AUG UUG CGA GGU AA
Amino acid: Met Leu Arg Gly
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Blame it on DNA: Review Song