doctor training for poly-mva lipoic acid mineral complex · cellular apoptosis pathway apoptosis ca...
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In learning we will teach,
and in teaching we will learn.
Doctor Training for POLY-MVA Lipoic Acid Mineral Complex
Targeted Integrative Biological Modifier
in “Metabolic Medicine”
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Mitochondrial Role in Aging and Disease
– Power Plant - Controls Life/Death – ATP for Function & Active Transport – Mitochondrial DNA - NO defenses – Oxidative Balance is necessary – Recycling and support of Antioxidants
Protection of DNA
Cell membrane
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METABOLISM Energy requirement between: – Anaerobic metabolism – without regard to
oxygen (produces 2 ATP) thru glycolysis – Aerobic metabolism – oxygen is required
(produces 34 ATP) via Oxidation of Pyruvate Krebs Cycle Oxidative Phosphorylation (e- transport chain)
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Pyruvate Kinase
PKM1 PKM2
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Cellular Apoptosis Pathway
Apoptosis
CAD
ICAD Endo
G
PI3K PKC
IkBa
SMAC
Arts
HTRA2
CIAP1
Caspase9
APAF1
Cytoc
MDM2
ATM
p53
EndoG
AIF
BAK
p90RSK Akt1
CAD
FLIP
p14(ARF)
Noxa
PARP
BID BAD
Caspase3
Caspase8
NF-kB
NF-kB
Apoptosis Apoptosis Depolari-
zation Oncogenic Signal
FLIP,CIAP2,BFL1, BCL2 BAK,BAK,BID,
Ras,Noxa,PUMA, APAF1,Survivin,
BCL2 DNA Fragmentation
Withdrawl of
Growth Factors
Apoptosis
IKKs
Procaspase8
TRAF2 RIP
MMP
BCL2 Caspase7
VDAC
Daxx
POD
Apo2/
Apo3
Procaspase8
tBID BCLX
L PMR
CypD
PML
p53
Chk2
2009 ProteinLounge.com C
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Oxygen trigger in the Mitochondria
HIF= Hypoxia Inducing Factor In a normoxic state it is catalytically destroyed Therefore, in a hypoxic state it increases HIF-1α forms a dimer with HIF-1β (a non-
hypoxia related molecule) and is activated.
ROLE: Allows physiologic and metabolic adaptation to a abnormal environment
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Taking Advantage of Metabolic Dysfunction
Oxygen is the final electron acceptor Hypothesis:
Providing alternative ENERGY source Hypoxic and/or cancer cells are limited
Normal cells are supplemented by it and thrive
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Dr. Merrill Garnett
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Lipoic Acid Mineral Complex (Trimer)
Bonding of electron accepting & donating mineral (palladium)
Alpha-Lipoic Acid water/fat soluble anti-oxidant
Thiamin (B1) resulted in the creation of a novel Redox complex!
Palladium
Lipoic Acid Thiamine
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POLY-MVA/(LAMC)
What is POLY-MVA? POLY: Lipoic Acid Mineral Complex M-inerals: Molybdenum, Rhodium,
Ruthenium V-itamins: B1, B2, B12 A-mino Acids: N-Acetyl Cysteine &
Formyl Methionine Designed to support and promote
cellular energy production.
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Poly-MVA Clean Room Manufacturing
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Differs from free radical scavengers (e.g. a lipoic acid) no free lipoic acid or B1
Irreversibly bound together resulting in a complex that is both fat and water soluble.
Poly-MVA is a polymer (liquid crystal) rather than a single molecule. Therefore, provides a unified redox (accept charge and donate charge) reaction.
An extremely effective energy transferring molecule
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ORAC Value Comparisons ORAC = Oxygen Radical Absorbance
Capacity (expressed as Trolox equivalent per gram)
Vitamin C = 1.12 (1,890) Melatonin = 2.04 (3,468) Lipoic Acid = 1.4 (2,400) Poly MVA = 5.65 (9,605) Brunswick Labs, Wareham, MA
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HOW DOES LIPOIC COMPLEX WORK?
Redox molecule that facilitates energy charge transfer Therefore: protects and provides energy source
Mimics the electron transport chain.
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LIPOIC ACID
+ Thiamine
Poly-MVA- Mechanism of Action and Role in Energy Metabolism
Poly-MVA
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Energy
O2
Generates Oxygen Radicals
Cytochrome c +
initiator caspase
+ APAF
= CANCER
CELL DEATH
Cancer Cell
APOPTOSIS
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Healthy
Cell
O2
Energy
Stabilize Electron Transport Chain
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POLY-MVA Targeting Varying hypoxic conditions are
associated with different disease. Provides an alternative mitochondrial
ENERGY source
in a hypoxic state, cancer cells move toward Apoptosis
Normal cells are supplemented and thrive
Regardless of oxygen state
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How to use POLY-MVA Nutrients
Other Antioxidants
Complementary and Integrative
An Integrative Approach
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Other Metabolic Therapies
CoQ10, D-ribose, L-Carnitine, NAD Magnesium, Potassium, B-Complex Glutathione, Vitamins - C, A, K, E, D
Targeting oxygen and metabolic energy production and pathways
Poly-MVA brings Energy to the cell
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Poly-MVA Osmolarity:
0.12m Osmol/ml
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MG PER ML 5ml 10ml 20ml 40ml ACTIVE LAMC
INGREDIENT
ALA/Thiamin mg ≈ 8/9mg 40 / 45mg 80/90mg 160/180g 320/360mg
Lipoic Acid Thiamin Pd Complex ≈
21mg 105mg 210mg 420mg 840mg
Co-Factors
B2 Riboflavin .2mg 1 mg 2 mg 4 mg 8 mg
B12 as cobalamin .2mg 1 mg 2 mg 4 mg 8 mg
Molybdenum .1mg .2mg .4mg .8mg 1.6mg
Rhodium .1mg .1mg .2mg .4mg .8mg
Ruthenium .1mg .1mg .1mg .1mg .1mg
Formyl Methionine .1mg .2mg .4mg .8mg 1.6mg
N-AcetylCystein .1mg .1mg .2mg .4mg .8mg
Poly Plus Vit A 50 IU 500IU 1000IU 2000IU 4000IU
Total Co-Factors ≈ 0.5mg 1.25mg 2.5mg 5.0mg 10mg
Sodium (mg) ≈ 3mg 15mg 30mg 60mg 120mg
ALA Equivalent ≈ 40mg 200mg 400mg 800mg 1600mg
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Applications and Research:
• Metabolically targeted therapy
• Alleviate mitochondrial damage and fatigue
• Potentiate chemo and radiotherapy • Attenuating their toxicity
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Poly-MVA / LAMC In Fatigue, Mitochondrial
& Neuro-inflammatory Disorders
Initial clinical applications:
1. Oncology treatment 2. Quality of Life Advancing applications: 3. Chronic illness treatment 4. Metabolic Dysfunction
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Combating Clinical Fatigue Multiple Sclerosis-associated fatigue:
Dr. Lauren Krupp, Stony Brook University, IND approved
• 80% of subject demonstrated statistically significant HIV-associated fatigue: Dr. Gary Blick, Circle Medical
• improvement in QOL/Energy/Fatigue:
Palliative Care - conducted by Pharmaceutical company CIPLA • Cognitive Functioning, Emotional Functioning,
Social Functioning, Fatigue, Sleep Disturbances, and Appetite Loss.
Floroquinillian/Anti-biotic associated fatigue:
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CANINE–Osteosarcoma Open Labeled Study
Median Survival (in days)
367
288
268
165
0 100 200 300 400
Amputation w/ Chemotherapy +Poly MVA (n=17)
Amputation w/ Chemotherapy (n = 32)
Amputation w/ Poly MVA (n=11)
Amputation Alone (n=162)
Ogilvie, G. (2008)
Poly-MVA improved median survival 62% (103 days) compared to surgery Poly-MVA with the chemotherapy regimen (carboplatin + doxorubicin) resulted in a 27% (79 days) longer median survival, with improved objective parameters (i.e. weight, anemia, liver and kidney function).
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Summary : Peer-reviewed studies have demonstrated the
ability of LAMC to: Anti-oxidant activity DNA protection and repair (human dose of 4 tsp/day)
Chromosomal protection Protected blood cells Increased spleen colony formation Attenuation of radiation-induced weight loss Enhanced radiotherapy Radiation-induced mitochondrial repair
4 months after chest radiation: Poly-MVA reduced markers of inflammatory infiltration
RADIATION STUDIES
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An NCI/NIH study at the University of Arkansas studied Poly
MVA on a model of radiation-induced heart disease.
Late administration of Poly-MVA (human dose of 2 tsp/day) mitigated mitochondrial alterations and attenuated cardiac
inflammatory markers when administered eighteen weeks after irradiation.
The authors concluded that “An earlier onset of Poly MVA administration
may have more profound effects
on radiation-induced cardiac remodeling".
Sridharan, V., Seawright, J., Antonawich, F.J., Garnett, M., Cao, M., Singh, P., Boerma, M. (2017) Late
Administration of a Palladium Lipoic Acid Complex (Poly-MVA) Modifies Cardiac Mitochondria Induced Heart
Disease in a Rat Model. Journal of Radiation Research 187(3): 361-366.
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Example: Integrated Protocol with POLY-MVA
Monday - INP + POLY-MVA IV
Tuesday - IPT + L - Glutathione IV-Oral Poly
Wednesday - Super “C”– 60 grams + H2O2 IV
Thursday - IPT + L - Glutathione IV-Oral Poly
Friday - INP + POLY-MVA IV
Immune Nutrient Protocol (INP)
Normal Saline L-Lysine and Zinc
B-Complex DMSO
Pyridoxine Folic Acid
Vitamin B-12 L-Glutathione
Vitamin C Magnesium Chloride
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Novel Combination Therapy researched in Non-responders
Historical ALA/Thiamine combination benefits Poly-MVA has multiple collateral potential
Anti-cancer Cell protective Increased ATP/enrgy to target Fatigue
DCA is effective but has neurological effects
(c) PS Anderson - www.consultDrA.com - 2020 34
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In Fatigue, Mitochondrial & Neuro-inflammatory Disorders
Paul S. Anderson, NMD © 2020
Typical series is (1) Vitamin-Mineral-Amino (2) Other (3) Other (4) Poly-MVA. Typically use for 6-12 weeks & then reassess.
First: Vit-Mineral-Amino formula Co-factors for mitochondrial and cellular function Second Optional: Glutathione/other Third Optional: Phosphatidylcholine /other Fourth: Poly-MVA
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Multi-agent IV therapy
– well tolerated
– positive symptomatic and quality of life
Poly in place of the ALA
Oral doses can be 5 to 40mL (1-8 tsp) BID
Used as support between IV or stand-alone.
Generally this is dosed 2 IV/week, oral on the off days 6-12 weeks, then maintenance
Option for only oral daily 10-40ml or 6-12 weeks
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All the benefits of Poly-MVA,
Plus the synergistic benefits of Vitamin A.
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Vitamin A aerobic metabolism
Facilitates iron mobilization to form
hemoglobin in red blood cells. Reduces anemia
When cells are deprived of Vitamin A the synthesis of ATP decreases as did respiration, they were restored when vitamin A was restored.
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Poly MVA: Increase metabolism and
ATP levels Demonstrate anti-oxidant
activity DNA and chromosome
protection Enhance DNA repair Attenuate radiation-
induced weight loss Protect blood cells and
increase spleen colony formation
Repair radiation-induced mitochondria
Enhance radio and chemotherapy
Poly-Plus Vit A: Enhance the visual
system Benefit skin: aging,
acne, dryness Strengthen the
immune system Improve health of
bones /teeth Facilitate erythrocyte
specialization & hemoglobin
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Vitamin A is normally fat soluble Developed a unique version that stays in Poly-MVA solution Poly-PLUS with Vitamin A Enhanced version of the Poly-MVA Potentiate cellular energy Attenuate fatigue Support Mitochondrial concerns
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50 year old Male no history of skin cancer. Been in the sun since he was a child ‘all summer long’ , swam competitively for 6 years. Continues to be outdoors and in desert areas with extreme sun and temperature exposure. Ignored scalpel growth for 10-12 months. Topical with cu-tip 1-3x/day for 60 days till gone June thru July 2015. Used Poly-MVA orally at ½ tsp.
CASE STUDY
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Same Male March 2019 Right side below temple growth 2 months of watchful waiting, Family making note of change
Applied topical with roll on 1-3x/day old skin/scab rolled off in 90 days Was using Poly-MVA orally at 1tsp
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Same Male Jan 2020 Cleaning ear and it bled immediately applied Poly-MVA via cue tip and saturated cotton ball 2-3x daily. Healed in 21 days and looks normal Used Poly-MVA orally at 1tsp
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Case 2 86 Year old Female abnormal growth. Had a telemedicine with current doctor. Answer was wait till Pandemic is over to see dermatologist. Growth was advancing weekly and she was very nervous. Family friend called and recommended Poly to do at least something. Currently at 12 days applying Poly 2-3x per day for with significant improvement.
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7 Additional Days
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Case 3 18 Year old Male non healing deep shin Injury Feb 5th, 2020. Healing normally. Reinjured March 20th, 2020 Wound not healing and still oozing despite cleaning, covering, various topical applications of silver, light therapy, peroxide thru the month of April and into May Started Poly Injections on May 10th Scabbed in 2 days by May 12th Injecting every 7-10 days and monitoring
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March 2020
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May 10 May 12
May 23
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Oxidative Stress in
Aging and Dry Eye Disease
Oxidative stress damages the ocular surface
Plays an important role in dry eye disease.
Investigate the therapeutic modalities employing topical/systemic use of antioxidants in dry eye disease.
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The Association for Research in Vision and Ophthalmology Copyright © 2020. All rights reserved.
From: Potential Role of Oxidative Stress in Ocular Surface Inflammation and Dry Eye Disease Invest. Ophthalmol. Vis. Sci.. 2018;59(14):DES163-DES168. doi:10.1167/iovs.17-23402
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Superoxide dismutase -SOD enzyme family is a major antioxidant system in all tissues An imbalance between radical-scavenging systems and free radical generation in the tears, Meibomian gland, and mitochondria may result in tissue inflammation, damage, and accumulation of ROS
Three reactions are particularly relevant to cell injury: – lipid peroxidation of membranes, – oxidative modification of proteins, – oxidative damage to DNA. The accumulation of ROS lead to Meibomian gland disease and dry eye disease.
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accumulating evidence suggests that oxidative stress may have a direct and/or indirect effect on ocular surface health plays an important role in the pathogenesis of several forms of dry eye. Therapeutic modalities employing topical/systemic use of antioxidants may have a promising future in the treatment of dry eye disease.
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Poly-MVA & Complementary Agents Melatonin Metformin DCA Salicinium Artesunate Ketogenic Diet
Curcumin
Photo/Light Therapy
Mistletoe
Naltrexone(LDN)
Oxaloacetate(NAD)
Vit C
Glutathione
Phosphatidylcholine
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Integrative Medicine Protects
Patient improvements are not gained at the expense of toxic therapies leaving them with many adverse side effects:
Painful Neuropathies
Cardiomyopathies
Renal Failure / Platinum toxicities
Hepatic Failure
Severe Pancytopenias
Pulmonary Fibrosis
Devastating Fatigue, Anorexia and Wasting Syndromes
Osteoarthritis, myalgias, osteoporosis
Severe dermatoses
Chemo Brain Syndrome
Death
Outcome studies support that the Biological/Integrative approach to advanced therapies is far more successful.
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“Information is the Force of Change”
Prevention is the most important and reliable
Dis-ease fighting tool that exists today.
Disease can be effectively treated, reversed and that prevention are the most important
messages we can share. www.polymva.com
www.electrogenetics.net www.consultDrA.com
https://www.ivnutritionaltherapy.com/
Email for Information: [email protected]